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Relevant bibliographies by topics / New Pyridazinonyl

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Journal articles

Academic literature on the topic 'New Pyridazinonyl'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "New Pyridazinonyl"

1

F., A. YASSIN, A. AHMED GAMAL, and Y. MOSTAFA H. "Synthesis of some New Pyridazinonyl, Naphthyl and Benzofluorenonyl Derivatives via Stobbe Condensation Reaction." Journal of Indian Chemical Society Vol. 73, Nov 1996 (1996): 620–22. https://doi.org/10.5281/zenodo.5918292.

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Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt <em>Manuscript received 10 January 1994, revised 27 January 1995, accepted 2 March 1995</em> Synthesis of some New Pyridazinonyl, Naphthyl and Benzofluorenonyl Derivatives via Stobbe Condensation Reaction.

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2

Rodriguez, Christina, Rachel Kiriakopoulos, Lana K. Hiscock, Zachary Schroeder, and Louise N. Dawe. "Pyridazinones from maleic hydrazide: a new substrate for the Mitsunobu reaction." Canadian Journal of Chemistry 98, no. 6 (2020): 273–77. http://dx.doi.org/10.1139/cjc-2019-0474.

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Crystal engineered organic frameworks assembled using hydrogen bonding are known, and examples constructed from hydroxypyridine/pyridone as the dominant source of hydrogen bonding have been reported. Less explored are analogous systems based on maleic hydrazide. Herein, a two-step route (Mitsunobu followed by Schiff base reactions) to asymmetrically substituted pyridazinones from maleic hydrazide (step 1) is reported with 2-, 3-, or 4-pyridinecarboxaldehyde (step 2). Upon reaction with 4-pyridinecarboxaldehyde, single crystals suitable for analysis via X-ray diffraction were obtained. Careful

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3

YASSIN, F. A., G. A. AHMED, and H. Y. MOSTAFA. "ChemInform Abstract: Synthesis of Some New Pyridazinonyl, Naphthyl and Benzofluorenonyl Derivatives via Stobbe Condensation Reaction." ChemInform 28, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199739052.

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4

Ismail, Magda M. F., Dalia H. S. Soliman, Mona H. Abd Elmoniem, and Ghehad A. R. Abdel Jaleel. "Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities." Medicinal Chemistry 17, no. 2 (2020): 171–86. http://dx.doi.org/10.2174/1573406416666200327191100.

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Background: Hypertension, one of the most common cardiovascular diseases that can cause coronary disease, stroke, myocardial infarction, and sudden death, it is the major contributor to cardiac failure as well as renal insufficiency. Objectives: As there are many cardio-active pyridazinone-base derivatives in clinical use, therefore, we aimed to synthesize a new series of pyridazin-3-ones and evaluate their vasorelaxant activity. Methods: A new series of synthesized compounds were carried out first by the synthesis of 6- flouroarylpyridazinones by cyclization of 3-(4-flourobenzoyl) propionic a

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5

Li, Hong Sen, Lin Jing Zhao, Jia Rong Tang, et al. "Study on New 3-(2H)-Pyridazinones Derivtives." Advanced Materials Research 524-527 (May 2012): 1751–54. http://dx.doi.org/10.4028/www.scientific.net/amr.524-527.1751.

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A series of novel pyridazinone derivatives was designed and synthesized. Insecticide activities of 7 pyridazinone derivatives were evaluated. The Preliminary bioassy test showed that compounds exhibited mild activity or moderate activity against Oriental armyworm at 200mg L-1

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6

Ivan, Beatrice-Cristina, Stefania-Felicia Barbuceanu, Camelia Mia Hotnog, et al. "Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-b]pyridazines Obtained via Mesoionic Oxazolo-Pyridazinones." International Journal of Molecular Sciences 24, no. 14 (2023): 11642. http://dx.doi.org/10.3390/ijms241411642.

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New pyrrolo[1,2-b]pyridazines were synthesized by 3 + 2 cycloaddition reaction between mesoionic oxazolo-pyridazinones and methyl/ethyl propiolate. The mesoionic compounds were generated in situ by action of acetic anhydride on 3(2H)pyridazinone acids obtained from corresponding esters by alkaline hydrolysis followed by acidification. The structures of the compounds were confirmed by elemental analyses and IR, 1H-NMR, 13C-NMR, and X-ray diffraction data. The regioselectivity of cycloaddition was evidenced by NMR spectroscopy and confirmed by X-ray analysis. The compounds were evaluated for the

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7

El Bakouri, Ouissam, Daniel Cassú, Miquel Solà, Teodor Parella, Anna Pla-Quintana, and Anna Roglans. "A new mild synthetic route to N-arylated pyridazinones from aryldiazonium salts." Chem. Commun. 50, no. 59 (2014): 8073–76. http://dx.doi.org/10.1039/c4cc03190c.

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8

Tao, Jing. "Synthesis of Aldehyde Hydrazones Containing Pyridazinone." Advanced Materials Research 361-363 (October 2011): 2008–11. http://dx.doi.org/10.4028/www.scientific.net/amr.361-363.2008.

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The reaction of 1,4,5,6-tetrahydro-6-pyridazinone-3-carboxylic acid hydrazides (1) and 1,6-dihydro-6-pyridazinone-3-carboxylic acid hydrazides (2) with four kind of substituted 3-formyl chromones (3a-3d) and five kind of 1-phenyl-3-aryl-4-formylpyrazoles (3e-3i) afforded the new compounds aldehyde hydrazones (4a-4i) and (5a-5i). Their structures were established by IR, 1H NMR and elemental analysis.

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9

Für, Csilla Sepsey, Gergő Riszter, János Gerencsér, et al. "Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character." Letters in Drug Design & Discovery 17, no. 6 (2020): 731–44. http://dx.doi.org/10.2174/1570180816666190710130119.

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Background: owadays, in course of the drug design and discovery much attention is paid to the physicochemical parameters of a drug candidate, in addition to their biological activity. Disadvantageous physicochemical parameters can hinder the success of a drug candidate. Objective: Lovering et al. introduced the Fsp3 character as a measure of carbon bond saturation, which is related to the physicochemical paramethers of the drug. The pharmaceutical research focuses on the synthesis of compounds with high Fsp3 character. Methods: To improve the physicochemical properties (clogP, solubility, more

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10

Dorina, Ionel, Vasilichia, and Violeta. "Bis-Pyridazine Derivatives with Anticancer Activity." Proceedings 22, no. 1 (2019): 6. http://dx.doi.org/10.3390/proceedings2019022006.

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Over the last decades, pyridazine derivatives are considered “privileged structures” in medicinal chemistry, with special attention being given to pyridazinones derivatives, which were found to have a large range of biological activities, including anticancer. On the other hand, because of the huge difficulties in cancer treatment, there is an urgent need from the pharmaceutical industry for new anticancer drug candidates. As part of our ongoing efforts in searching for new biologically active entities with anticancer potential, we report here the design, synthesis, structure and in vitro anti

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