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Journal articles on the topic 'New Pyridazinonyl'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

F., A. YASSIN, A. AHMED GAMAL, and Y. MOSTAFA H. "Synthesis of some New Pyridazinonyl, Naphthyl and Benzofluorenonyl Derivatives via Stobbe Condensation Reaction." Journal of Indian Chemical Society Vol. 73, Nov 1996 (1996): 620–22. https://doi.org/10.5281/zenodo.5918292.

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Chemistry Department, Faculty of Science, Zagazig University, Zagazig, Egypt <em>Manuscript received 10 January 1994, revised 27 January 1995, accepted 2 March 1995</em> Synthesis of some New Pyridazinonyl, Naphthyl and Benzofluorenonyl Derivatives via Stobbe Condensation Reaction.

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2

Rodriguez, Christina, Rachel Kiriakopoulos, Lana K. Hiscock, Zachary Schroeder, and Louise N. Dawe. "Pyridazinones from maleic hydrazide: a new substrate for the Mitsunobu reaction." Canadian Journal of Chemistry 98, no. 6 (2020): 273–77. http://dx.doi.org/10.1139/cjc-2019-0474.

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Crystal engineered organic frameworks assembled using hydrogen bonding are known, and examples constructed from hydroxypyridine/pyridone as the dominant source of hydrogen bonding have been reported. Less explored are analogous systems based on maleic hydrazide. Herein, a two-step route (Mitsunobu followed by Schiff base reactions) to asymmetrically substituted pyridazinones from maleic hydrazide (step 1) is reported with 2-, 3-, or 4-pyridinecarboxaldehyde (step 2). Upon reaction with 4-pyridinecarboxaldehyde, single crystals suitable for analysis via X-ray diffraction were obtained. Careful

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3

YASSIN, F. A., G. A. AHMED, and H. Y. MOSTAFA. "ChemInform Abstract: Synthesis of Some New Pyridazinonyl, Naphthyl and Benzofluorenonyl Derivatives via Stobbe Condensation Reaction." ChemInform 28, no. 39 (2010): no. http://dx.doi.org/10.1002/chin.199739052.

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4

Ismail, Magda M. F., Dalia H. S. Soliman, Mona H. Abd Elmoniem, and Ghehad A. R. Abdel Jaleel. "Synthesis, Molecular Modeling of Novel Substituted Pyridazinones and their Vasorelaxant Activities." Medicinal Chemistry 17, no. 2 (2020): 171–86. http://dx.doi.org/10.2174/1573406416666200327191100.

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Background: Hypertension, one of the most common cardiovascular diseases that can cause coronary disease, stroke, myocardial infarction, and sudden death, it is the major contributor to cardiac failure as well as renal insufficiency. Objectives: As there are many cardio-active pyridazinone-base derivatives in clinical use, therefore, we aimed to synthesize a new series of pyridazin-3-ones and evaluate their vasorelaxant activity. Methods: A new series of synthesized compounds were carried out first by the synthesis of 6- flouroarylpyridazinones by cyclization of 3-(4-flourobenzoyl) propionic a

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5

Li, Hong Sen, Lin Jing Zhao, Jia Rong Tang, et al. "Study on New 3-(2H)-Pyridazinones Derivtives." Advanced Materials Research 524-527 (May 2012): 1751–54. http://dx.doi.org/10.4028/www.scientific.net/amr.524-527.1751.

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A series of novel pyridazinone derivatives was designed and synthesized. Insecticide activities of 7 pyridazinone derivatives were evaluated. The Preliminary bioassy test showed that compounds exhibited mild activity or moderate activity against Oriental armyworm at 200mg L-1

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6

Ivan, Beatrice-Cristina, Stefania-Felicia Barbuceanu, Camelia Mia Hotnog, et al. "Synthesis, Characterization and Cytotoxic Evaluation of New Pyrrolo[1,2-b]pyridazines Obtained via Mesoionic Oxazolo-Pyridazinones." International Journal of Molecular Sciences 24, no. 14 (2023): 11642. http://dx.doi.org/10.3390/ijms241411642.

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New pyrrolo[1,2-b]pyridazines were synthesized by 3 + 2 cycloaddition reaction between mesoionic oxazolo-pyridazinones and methyl/ethyl propiolate. The mesoionic compounds were generated in situ by action of acetic anhydride on 3(2H)pyridazinone acids obtained from corresponding esters by alkaline hydrolysis followed by acidification. The structures of the compounds were confirmed by elemental analyses and IR, 1H-NMR, 13C-NMR, and X-ray diffraction data. The regioselectivity of cycloaddition was evidenced by NMR spectroscopy and confirmed by X-ray analysis. The compounds were evaluated for the

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7

El Bakouri, Ouissam, Daniel Cassú, Miquel Solà, Teodor Parella, Anna Pla-Quintana, and Anna Roglans. "A new mild synthetic route to N-arylated pyridazinones from aryldiazonium salts." Chem. Commun. 50, no. 59 (2014): 8073–76. http://dx.doi.org/10.1039/c4cc03190c.

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8

Tao, Jing. "Synthesis of Aldehyde Hydrazones Containing Pyridazinone." Advanced Materials Research 361-363 (October 2011): 2008–11. http://dx.doi.org/10.4028/www.scientific.net/amr.361-363.2008.

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The reaction of 1,4,5,6-tetrahydro-6-pyridazinone-3-carboxylic acid hydrazides (1) and 1,6-dihydro-6-pyridazinone-3-carboxylic acid hydrazides (2) with four kind of substituted 3-formyl chromones (3a-3d) and five kind of 1-phenyl-3-aryl-4-formylpyrazoles (3e-3i) afforded the new compounds aldehyde hydrazones (4a-4i) and (5a-5i). Their structures were established by IR, 1H NMR and elemental analysis.

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9

Für, Csilla Sepsey, Gergő Riszter, János Gerencsér, et al. "Synthesis of Spiro[cycloalkane-pyridazinones] with High Fsp3 Character." Letters in Drug Design & Discovery 17, no. 6 (2020): 731–44. http://dx.doi.org/10.2174/1570180816666190710130119.

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Background: owadays, in course of the drug design and discovery much attention is paid to the physicochemical parameters of a drug candidate, in addition to their biological activity. Disadvantageous physicochemical parameters can hinder the success of a drug candidate. Objective: Lovering et al. introduced the Fsp3 character as a measure of carbon bond saturation, which is related to the physicochemical paramethers of the drug. The pharmaceutical research focuses on the synthesis of compounds with high Fsp3 character. Methods: To improve the physicochemical properties (clogP, solubility, more

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10

Dorina, Ionel, Vasilichia, and Violeta. "Bis-Pyridazine Derivatives with Anticancer Activity." Proceedings 22, no. 1 (2019): 6. http://dx.doi.org/10.3390/proceedings2019022006.

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Over the last decades, pyridazine derivatives are considered “privileged structures” in medicinal chemistry, with special attention being given to pyridazinones derivatives, which were found to have a large range of biological activities, including anticancer. On the other hand, because of the huge difficulties in cancer treatment, there is an urgent need from the pharmaceutical industry for new anticancer drug candidates. As part of our ongoing efforts in searching for new biologically active entities with anticancer potential, we report here the design, synthesis, structure and in vitro anti

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11

Ghani, Essam Abdel. "Synthesis and Reactions of Some New Pyridazinones." Bulletin of the Chemical Society of Japan 64, no. 6 (1991): 2032–34. http://dx.doi.org/10.1246/bcsj.64.2032.

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12

KANDILE, N. G., and E. A. AHMED. "ChemInform Abstract: Synthesis of Some New Pyridazinones." ChemInform 22, no. 33 (2010): no. http://dx.doi.org/10.1002/chin.199133197.

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13

Rajkumar, Subramani, S. Antony Savarimuthu, Rajendran Senthil Kumaran, C. M. Nagaraja, and Thirumanavelan Gandhi. "Expedient synthesis of new cinnoline diones by Ru-catalyzed regioselective unexpected deoxygenation-oxidative annulation of propargyl alcohols with phthalazinones and pyridazinones." Chemical Communications 52, no. 12 (2016): 2509–12. http://dx.doi.org/10.1039/c5cc09347c.

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14

Ramadan, Sayed K., Doaa R. Abdel Haleem, Hisham S. M. Abd-Rabboh, Nourhan M. Gad, Wael S. I. Abou-Elmagd, and David S. A. Haneen. "Synthesis, SAR studies, and insecticidal activities of certain N-heterocycles derived from 3-((2-chloroquinolin-3-yl)methylene)-5-phenylfuran-2(3H)-one against Culex pipiens L. larvae." RSC Advances 12, no. 22 (2022): 13628–38. http://dx.doi.org/10.1039/d2ra02388a.

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A new series of N-heterocycles including pyridazinone, oxadiazole, triazolopyridazinone, and triazole derivatives were synthesized from the acid hydrazide via its reaction with certain carbon electrophiles.

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15

Moniot, Aurélie, Julien Braux, Camille Bour, et al. "Pyridazinone Derivatives Limit Osteosarcoma-Cells Growth In Vitro and In Vivo." Cancers 13, no. 23 (2021): 5992. http://dx.doi.org/10.3390/cancers13235992.

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Osteosarcoma is a rare primary bone cancer that mostly affects children and young adults. Current therapeutic approaches consist of combining surgery and chemotherapy but remain unfortunately insufficient to avoid relapse and metastases. Progress in terms of patient survival has remained the same for 30 years. In this study, novel pyridazinone derivatives have been evaluated as potential anti-osteosarcoma therapeutics because of their anti-type 4 phosphodiesterase activity, which modulates the survival of several other cancer cells. By using five—four human and one murine osteosarcoma—cell lin

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16

Kotynia, Aleksandra, Edward Krzyżak, Julia Żądło, et al. "Anti-Inflammatory and Antioxidant Pyrrolo[3,4-d]pyridazinone Derivatives Interact with DNA and Bind to Plasma Proteins—Spectroscopic and In Silico Studies." International Journal of Molecular Sciences 25, no. 3 (2024): 1784. http://dx.doi.org/10.3390/ijms25031784.

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From the point of view of the search for new pharmaceuticals, pyridazinone derivatives are a very promising group of compounds. In our previous works, we have proved that newly synthesized ligands from this group have desirable biological and pharmacokinetic properties. Therefore, we decided to continue the research evaluating the activity of pyrrolo[3,4-dpyridazinone derivatives. In this work, we focused on the interactions of five pyridazinone derivatives with the following biomolecules: DNA and two plasma proteins: orosomucoid and gamma globulin. Using several of spectroscopic methods, such

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17

Corsano, S., G. Strappaghetti, A. Codagnone, R. Scapicchi, and G. Marucci. "Synthesis and pharmacological activity of some new pyridazinones." European Journal of Medicinal Chemistry 27, no. 5 (1992): 545–49. http://dx.doi.org/10.1016/0223-5234(92)90189-8.

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18

Corsano, S., R. Vezza, R. Scapicchi, et al. "New pyridazinone derivatives as inhibitors of platelet aggregation." European Journal of Medicinal Chemistry 30, no. 7-8 (1995): 627–31. http://dx.doi.org/10.1016/0223-5234(96)88278-x.

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19

Costas, Tamara, María Carmen Costas-Lago, Noemí Vila, Pedro Besada, Ernesto Cano, and Carmen Terán. "New platelet aggregation inhibitors based on pyridazinone moiety." European Journal of Medicinal Chemistry 94 (April 2015): 113–22. http://dx.doi.org/10.1016/j.ejmech.2015.02.061.

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20

Mikus, Jakub, Piotr Świątek, Patrycja Przybyła, et al. "Synthesis, Biological, Spectroscopic and Computational Investigations of Novel N-Acylhydrazone Derivatives of Pyrrolo[3,4-d]pyridazinone as Dual COX/LOX Inhibitors." Molecules 28, no. 14 (2023): 5479. http://dx.doi.org/10.3390/molecules28145479.

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Secure and efficient treatment of diverse pain and inflammatory disorders is continually challenging. Although NSAIDs and other painkillers are well-known and commonly available, they are sometimes insufficient and can cause dangerous adverse effects. As yet reported, derivatives of pyrrolo[3,4-d]pyridazinone are potent COX-2 inhibitors with a COX-2/COX-1 selectivity index better than meloxicam. Considering that N-acylhydrazone (NAH) moiety is a privileged structure occurring in many promising drug candidates, we decided to introduce this pharmacophore into new series of pyrrolo[3,4-d]pyridazi

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21

Al-Awadhi, Hanan, Fatima Al-Omran, Mohamed H. Elnagdi, et al. "New synthetic approaches to condensed pyridazinones: alkylpyridazinyl carbonitriles as building blocks for the synthesis of condensed pyridazinones." Tetrahedron 51, no. 46 (1995): 12745–62. http://dx.doi.org/10.1016/0040-4020(95)00829-w.

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22

Alagöz, Mehmet Abdullah, Zeynep Özdemir, Mehtap Uysal, et al. "Synthesis, Cytotoxicity and Anti-Proliferative Activity against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker." Pharmaceuticals 14, no. 3 (2021): 183. http://dx.doi.org/10.3390/ph14030183.

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Novel twenty-three 3(2H)-pyridazinone derivatives were designed and synthesized based on the chemical requirements related to the anti-proliferative effects previously demonstrated within this scaffold. The introduction of a piperazinyl linker between the pyridazinone nucleus and the additional (un)substituted phenyl group led to some compounds endowed with a limited cytotoxicity against human gingival fibroblasts (HGFs) and good anti-proliferative effects against gastric adenocarcinoma cells (AGS) as evaluated by MTT and LDH assays, using doxorubicin as a positive control. Successive analyses

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23

Zhou, Yuefen, Lian-Sheng Li, Jingjing Zhao, et al. "Synthesis of New Pyridazinone Derivatives: 2,6-Disubstituted 5-Hydroxy-3(2H)-pyridazinone-4-carboxylic Acid Ethyl Esters." Synthesis 2007, no. 21 (2007): 3301–8. http://dx.doi.org/10.1055/s-2007-990823.

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24

ABDEL GHANI, E. "ChemInform Abstract: Synthesis and Reactions of Some New Pyridazinones." ChemInform 22, no. 36 (2010): no. http://dx.doi.org/10.1002/chin.199136210.

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25

Husain, Asif, Sushma Drabu, Nitin Kumar, M. Mumtaz Alam, and Aftab Ahmad. "Synthesis and biological evaluation of some new pyridazinone derivatives." Journal of Enzyme Inhibition and Medicinal Chemistry 26, no. 5 (2011): 742–48. http://dx.doi.org/10.3109/14756366.2010.548810.

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26

Sepsey Für, Csilla, and Hedvig Bölcskei. "New Spiro[cycloalkane-pyridazinone] Derivatives with Favorable Fsp3 Character." Chemistry 2, no. 4 (2020): 837–48. http://dx.doi.org/10.3390/chemistry2040055.

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The large originator pharmaceutical companies need more and more new compounds for their molecule banks, because high throughput screening (HTS) is still a widely used method to find new hits in the course of the lead discovery. In the design and synthesis of a new compound library, important points are in focus nowadays: Lipinski’s rule of five (RO5); the high Fsp3 character; the use of bioisosteric heterocycles instead of aromatic rings. With said aim in mind, we have synthesized a small compound library of new spiro[cycloalkane-pyridazinones] with 36 members. The compounds with this new sca

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27

Meyer, E., A. C. Joussef, H. Gallardo, and L. de B. P. de Souza. "Synthesis of New 4,5‐Dihydro‐3(2H)‐pyridazinone Derivatives." Synthetic Communications 34, no. 5 (2004): 783–93. http://dx.doi.org/10.1081/scc-120028351.

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28

Thota, Sridhar, and Ranju Bansal. "Synthesis of new pyridazinone derivatives as platelet aggregation inhibitors." Medicinal Chemistry Research 19, no. 8 (2009): 808–16. http://dx.doi.org/10.1007/s00044-009-9232-6.

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29

Costas, Tamara, Pedro Besada, Alessandro Piras, et al. "New pyridazinone derivatives with vasorelaxant and platelet antiaggregatory activities." Bioorganic & Medicinal Chemistry Letters 20, no. 22 (2010): 6624–27. http://dx.doi.org/10.1016/j.bmcl.2010.09.031.

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30

Darwish, Elham S., Mahmoud A. Abdelrahman, and Abdellatif M. Salaheldin. "Enamines in Heterocyclic Synthesis: A Novel Simple and Efficient Route to Condensed Pyridazines." Zeitschrift für Naturforschung B 66, no. 6 (2011): 597–602. http://dx.doi.org/10.1515/znb-2011-0607.

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An efficient and easy preparation of enamine derivatives, via active methyl and methylene compounds by in situ-generated 1-(diethoxymethyl)piperidine, produced from the mixture of triethyl orthoformate/piperidine/DMF, are described. Some new pyridazinone derivatives have been synthesized from the reaction of enamines with hydrazine hydrate and cyanoacid hydrazide.

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31

Sepsey Für, Csilla, György Keglevich, and Hedvig Bölcskei. "Unexpected Formation of 4-aryl-1-(Propane-2-ylidenehydrazono)-2,3-diazaspiro[5.5]undec-3-ene by the Reaction of Pyridazinethiones Derivatives with Hydrazine." Molbank 2021, no. 3 (2021): M1243. http://dx.doi.org/10.3390/m1243.

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After making a new series of spiro[cycloalkane]pyridazinones with high Fsp3 character available, the new target was to synthesize derivatives comprising nitrogen-containing heterocycles, such as triazolo or tetrazolo rings. The corresponding thioxo derivatives (1a,b) seemed to be good starting materials for the synthesis of tetrazolo derivatives. The reaction of the pyridazinethiones (1a,b) with hydrazine surprisingly resulted in Schiff bases (3a,b) deriving from the reaction of hydrazones (2a,b) with acetone.

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32

Fatisa, Yuni, Noval Herfindo, Fadila Aisyah, et al. "Efficient Synthesis using One-Pot Method and In Silico Analysis of Pyridazinone Derivatives as Inhibitor for Aldose Reductase Enzymes." Trends in Sciences 22, no. 4 (2025): 9396. https://doi.org/10.48048/tis.2025.9396.

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This research aims to synthesize a series of pyridazinone derivatives (4a-4d, 5, 6a-6d), investigate their activities against the aldose reductase enzyme, and analyze their pharmacology profiles. Substituted-acetophenone were reacted with glyoxylic acid and hydrazine through a one-pot process using a heating reactor to obtain compounds 4a - 4d. Meanwhile, compounds 5 and 6a - 6d using a stirring technique, were synthesized combining compound 4d with p-chloro benzene sulphonic acid for compound 5 and combining compounds 4a - 4d with ethyl chloro acetate to produce compounds 6a - 6d. The MOE 202

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33

Cao, Song, Xuhong Qian, Gonghua Song, Bing Chai, and Zhisheng Jiang. "Synthesis and Antifeedant Activity of New Oxadiazolyl 3(2H)-Pyridazinones." Journal of Agricultural and Food Chemistry 51, no. 1 (2003): 152–55. http://dx.doi.org/10.1021/jf0208029.

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34

Frizzo, Clarissa P., Marcos A. Villetti, Aniele Z. Tier, et al. "Structural and thermodynamic properties of new pyrazolo[3,4-d]pyridazinones." Thermochimica Acta 574 (December 2013): 63–72. http://dx.doi.org/10.1016/j.tca.2013.08.017.

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35

Jonas, R., H. Prücher, and H. Wurziger. "Synthesis of a new type of ‘bent’ heterocyclic benzimidazolo-pyridazinones." European Journal of Medicinal Chemistry 28, no. 2 (1993): 141–48. http://dx.doi.org/10.1016/0223-5234(93)90006-z.

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36

CORSANO, S., G. STRAPPAGHETTI, A. CODAGNONE, R. SCAPICCHI, and G. MARUCCI. "ChemInform Abstract: Synthesis and Pharmacological Activity of Some New Pyridazinones." ChemInform 24, no. 2 (2010): no. http://dx.doi.org/10.1002/chin.199302206.

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37

CARMELLINO, M. L., G. MASSOLINI, G. PAGANI, F. ZANI, and G. LERI. "ChemInform Abstract: Fungicidal and Genotoxic Activity of New Substituted Pyridazinones." ChemInform 25, no. 12 (2010): no. http://dx.doi.org/10.1002/chin.199412215.

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38

AL-AWADHI, H., F. AL-OMRAN, M. H. ELNAGDI, et al. "ChemInform Abstract: New Synthetic Approaches to Condensed Pyridazinones: Alkylpyridazinyl Carbonitriles (V) as Building Blocks for the Synthesis of Condensed Pyridazinones." ChemInform 27, no. 11 (2010): no. http://dx.doi.org/10.1002/chin.199611192.

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39

Corsano, S., R. Scapicchi, G. Strappaghetti, G. Marucci та F. Paparelli. "New pyridazinones: synthesis and correlation between structure and α-blocking activity". European Journal of Medicinal Chemistry 28, № 7-8 (1993): 647–51. http://dx.doi.org/10.1016/0223-5234(93)90097-x.

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40

Mantu, Dorina, Vasilichia Antoci, Alina Nicolescu, Calin Deleanu, Violeta Vasilache, and Ionel Mangalagiu. "Synthesis, Stereochemical Studies and Antimycobacterial Activity of New Acetyl- Hydrazine Pyridazinones." Current Organic Synthesis 14, no. 1 (2016): 112–19. http://dx.doi.org/10.2174/1570179413999160219164248.

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41

Yamasaki, Tetsuo, Yuji Yoshihara, Yoshinari Okamoto, Tadashi Okawara, and Mitsuru Furukawa. "A new approach to the synthesis of pyridazino[4,5-c]pyridazinones." Journal of Heterocyclic Chemistry 29, no. 5 (1992): 1313–16. http://dx.doi.org/10.1002/jhet.5570290543.

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42

Soliman, Mohamed H. A., and Sahar S. El-Sakka. "Synthesis of Some New 4,5-dihydro-6-(4-methoxy-3-methylphenyl)-3(2H)-pyridazinone Derivatives." Journal of the Korean Chemical Society 55, no. 2 (2011): 230–34. http://dx.doi.org/10.5012/jkcs.2011.55.2.230.

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43

Shi, Qinjie, Yanxia Shi, Kang Chang, et al. "3(2H)-pyridazinone derivatives: a new scaffold for novel plant activators." RSC Advances 9, no. 62 (2019): 36204–7. http://dx.doi.org/10.1039/c9ra06892a.

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44

Malinka, Wiesław, Aleksandra Redzicka, and Olivier Lozach. "New derivatives of pyrrolo[3,4-d]pyridazinone and their anticancer effects." Il Farmaco 59, no. 6 (2004): 457–62. http://dx.doi.org/10.1016/j.farmac.2004.03.002.

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45

SONMEZ, M., I. BERBER, and E. AKBAS. "Synthesis, antibacterial and antifungal activity of some new pyridazinone metal complexes." European Journal of Medicinal Chemistry 41, no. 1 (2006): 101–5. http://dx.doi.org/10.1016/j.ejmech.2005.10.003.

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46

Costas, Tamara, Pedro Besada, Alessandro Piras, et al. "ChemInform Abstract: New Pyridazinone Derivatives with Vasorelaxant and Platelet Antiaggregatory Activities." ChemInform 42, no. 11 (2011): no. http://dx.doi.org/10.1002/chin.201111176.

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47

Szczukowski, Łukasz, Edward Krzyżak, Adrianna Zborowska, et al. "Design, Synthesis and Comprehensive Investigations of Pyrrolo[3,4-d]pyridazinone-Based 1,3,4-Oxadiazole as New Class of Selective COX-2 Inhibitors." International Journal of Molecular Sciences 21, no. 24 (2020): 9623. http://dx.doi.org/10.3390/ijms21249623.

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The long-term use of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) in treatment of different chronic inflammatory disorders is strongly restricted by their serious gastrointestinal adverse effects. Therefore, there is still an urgent need to search for new, safe, and efficient anti-inflammatory agents. Previously, we have reported the Mannich base-type derivatives of pyrrolo[3,4-d]pyridazinone which strongly inhibit cyclooxygenase, have better affinity to COX-2 isoenzyme and exert promising anti-oxidant activity. These findings encouraged us to perform further optimization of that structure.

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48

Costas-Lago, María Carmen, Tamara Costas, Noemí Vila, and Carmen Terán. "5-[(tert-Butyldiphenylsilyloxy)methyl]pyridazin-3(2H)-one." Acta Crystallographica Section E Structure Reports Online 69, no. 12 (2013): o1826—o1827. http://dx.doi.org/10.1107/s160053681303167x.

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In the title compound, C21H24N2O2Si, a new pyridazin-3(2H)-one derivative, the carbonyl group of the heterocyclic ring and the O atom of the silyl ether are located on the same side of the pyridazinone ring and the C—C—O—Si torsion angle is −140.69 (17)°. In the crystal, molecules are linked by pairs of strong N—H...O hydrogen bonds into centrosymmetric dimers with graph-set notationR22(8). Weak C—H...π interactions are also observed.

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Merwid-Ląd, Anna, Piotr Ziółkowski, Beata Nowak, et al. "1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone Alleviate TNBS-Induced Colitis and Exhibit No Significant Testicular Toxicity." Pharmaceuticals 18, no. 4 (2025): 546. https://doi.org/10.3390/ph18040546.

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Background/Objectives: Inflammatory bowel disease significantly impairs the patient’s quality of life. In young individuals, both the disease and the drugs used for the treatment may impact fertility. Our study aimed to assess the action of new 1,3,4-oxadiazole derivatives of pyrrolo[3,4-d]pyridazinone on the rat testes in a model of TNBS-induced colitis in rats. Methods: In the current study, testes from eight randomly chosen rats were taken from each of the following groups: the control group (K), the colitis group (C), and the groups receiving compounds 7b, 10b, and 13b in higher doses (20

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Wang, Ya-Juan, Dong Lu, Yi-Bin Xu, et al. "A Novel Pyridazinone Derivative Inhibits Hepatitis B Virus Replication by Inducing Genome-Free Capsid Formation." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 7061–72. http://dx.doi.org/10.1128/aac.01558-15.

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ABSTRACTHere we first identified a novel pyridazinone derivative, compound 3711, as a nonnucleosidic hepatitis B virus (HBV) inhibitor in a cell model system. 3711 decreased extracellular HBV DNA levels by 50% (50% inhibitory concentration [IC50]) at 1.5 ± 0.2 μM and intracellular DNA levels at 1.9 ± 0.1 μM, which demonstrated antiviral activity at levels far below those associated with toxicity. Both the 3TC/ETV dually resistant L180M/M204I mutant and the adefovir (ADV)-resistant A181T/N236T mutant were as susceptible to 3711 as wild-type HBV. 3711 treatment induced the formation of genome-fr

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