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Journal articles on the topic 'New Synthetic Channel'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Latha Jeevigunta, Naveena Lavanya, E. Susithra, Gouthami Thumma, MV Basaveswara Rao, and Kiran Gangarapu. "A comprehensive review of peptide toxins vs synthetic modulators of BK channels in Epilepsy." Obstetrics Gynecology and Reproductive Sciences 5, no. 05 (2021): 01–07. http://dx.doi.org/10.31579/2578-8965/082.

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BK channels, or voltage-gated Ca2+ channels, are essential regulators of neuronal excitability and muscular contractions, all of which are abnormal in epilepsy, a chronic neuronal disease. The form, frequency, and transmission of action potentials (APs), as well as neurotransmitter release from presynaptic terminals, are all influenced by BK channels found in the plasma membrane of neurons. Over the last two decades, several naturally occurring BK channel modulators have attracted a lot of attention. The structural and pharmacological properties of BK channel blockers are discussed in this art

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Lawson, Kim. "Is there a Therapeutic Future for ‘Potassium Channel Openers’?" Clinical Science 91, no. 6 (1996): 651–63. http://dx.doi.org/10.1042/cs0910651.

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1. Potassium channels, which control cell electrical activity, are among the most regulated of all ion channels in biology. Promotion of activity in K+ channels by a wide range of physiological factors tends to stabilize cell function. 2. The discovery of synthetic molecules (e.g. cromakalim) that ‘directly’ open ATP-sensitive K+ channels has led to a new direction in pharmacology. ATP-sensitive K+ channel-opening properties have subsequently been demonstrated in a diverse range of chemical structures (synthetic and endogenous). 3. The existence of so many different subtypes of K+ channels has

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Drăgoi, Vlad-Florin, and Gabriela Cristescu. "Bhattacharyya Parameter of Monomial Codes for the Binary Erasure Channel: From Pointwise to Average Reliability." Sensors 21, no. 9 (2021): 2976. http://dx.doi.org/10.3390/s21092976.

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Monomial codes were recently equipped with partial order relations, a fact that allowed researchers to discover structural properties and efficient algorithm for constructing polar codes. Here, we refine the existing order relations in the particular case of the binary erasure channel. The new order relation takes us closer to the ultimate order relation induced by the pointwise evaluation of the Bhattacharyya parameter of the synthetic channels, which is still a partial order relation. To overcome this issue, we appeal to a related technique from network theory. Reliability network theory was

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Bacsa, Bernadett, Valentina Hopl, and Isabella Derler. "Synthetic Biology Meets Ca2+ Release-Activated Ca2+ Channel-Dependent Immunomodulation." Cells 13, no. 6 (2024): 468. http://dx.doi.org/10.3390/cells13060468.

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Many essential biological processes are triggered by the proximity of molecules. Meanwhile, diverse approaches in synthetic biology, such as new biological parts or engineered cells, have opened up avenues to precisely control the proximity of molecules and eventually downstream signaling processes. This also applies to a main Ca2+ entry pathway into the cell, the so-called Ca2+ release-activated Ca2+ (CRAC) channel. CRAC channels are among other channels are essential in the immune response and are activated by receptor–ligand binding at the cell membrane. The latter initiates a signaling cas

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Nandiasa, Jantiara Eka, and Ridwan Adi Sanjaya. "Evaluation of Drainage Channels on Pabuaran Road Cibinong District of Bogor Regency." IJTI (International Journal of Transportation and Infrastructure) 4, no. 1 (2020): 22–35. http://dx.doi.org/10.29138/ijti.v4i1.1162.

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Drainage can be generally defined as a technical measure to reduce excess water, whether from rain, seepage, or excess irrigation water from an area / land, so that the function of the area / land is not disturbed. This study aims to analyze, assess and evaluate the condition and capacity of the channel in the sub-district Pabuaran Road Bogor Cibinong District to discharge the flooding. Data and information used is primary data in the form of rainfall data from the Meteorology and Geophysics from the nearest irrigation hall as well as secondary data, the authors survey directly at the sites. I

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WILLIAMS, Keith. "Interactions of polyamines with ion channels." Biochemical Journal 325, no. 2 (1997): 289–97. http://dx.doi.org/10.1042/bj3250289.

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Endogenous polyamines, in particular spermine, have been found to cause block and modulation of a number of types of ion channel. Intracellular spermine is responsible for intrinsic gating and rectification of strong inward rectifier K+ channels by directly plugging the ion channel pore. These K+ channels control the resting membrane potential in both excitable and non-excitable cells, and control the excitability threshold in neurons and muscle cells. Intracellular spermine causes inward rectification at some subtypes of Ca2+-permeable glutamate receptors in the central nervous system, again

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Depuydt, Anne-Sophie, Piyush A. Patel, Žan Toplak, et al. "Structure-Function Studies of Sponge-Derived Compounds on the Cardiac CaV3.1 Channel." International Journal of Molecular Sciences 24, no. 4 (2023): 3429. http://dx.doi.org/10.3390/ijms24043429.

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T-type calcium (CaV3) channels are involved in cardiac automaticity, development, and excitation–contraction coupling in normal cardiac myocytes. Their functional role becomes more pronounced in the process of pathological cardiac hypertrophy and heart failure. Currently, no CaV3 channel inhibitors are used in clinical settings. To identify novel T-type calcium channel ligands, purpurealidin analogs were electrophysiologically investigated. These compounds are alkaloids produced as secondary metabolites by marine sponges, and they exhibit a broad range of biological activities. In this study,

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Yun, Jaesuk, Kyung Sik Yoon, Tac-Hyung Lee, et al. "Synthetic cannabinoid, JWH-030, induces QT prolongation through hERG channel inhibition." Toxicology Research 5, no. 6 (2016): 1663–71. http://dx.doi.org/10.1039/c6tx00259e.

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The problem of new psychoactive substance (NPS) abuse, which includes synthetic cannabinoids, is emerging globally, and the cardiotoxicity of these synthetic cannabinoids has not yet been evaluated extensively.

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Nguyen, Huy Du, Takuya Okada, Fumiko Sekiguchi, et al. "Prenylflavanones as Novel T-Type Calcium Channel Blockers Useful for Pain Therapy." Natural Product Communications 14, no. 9 (2019): 1934578X1987344. http://dx.doi.org/10.1177/1934578x19873441.

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Prenylated flavonoids have attracted much attention due to their promising and diverse bioactivities on multitarget tissues. To the best of our knowledge, our recent studies demonstrated first that (2 S)-6-prenylnaringenin (6-PNG), a hop component, blocks Cav3.2 T-type calcium channels (T-channels) and alleviates neuropathic and visceral pain with little side effects; it also indicated first that other natural prenylflavanones (PFVNs), such as sophoraflavanone G and (2 S)-8-PNG, or synthetic 6-PFVNs including (2 R/S)-6-PNG and its derivatives are capable of blocking T-channels and useful for p

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Pham, Nam, Sergey Fomel, and Dallas Dunlap. "Automatic channel detection using deep learning." Interpretation 7, no. 3 (2019): SE43—SE50. http://dx.doi.org/10.1190/int-2018-0202.1.

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We have developed a method based on an encoder-decoder convolutional neural network for automatic channel detection in 3D seismic volumes. We use two architectures borrowed from computer vision: SegNet for image segmentation together with Bayesian SegNet for uncertainty measurement. We train the network on 3D synthetic volumes and then apply it to field data. We test the proposed approach on a 3D field data set from the Browse Basin, offshore Australia, and a 3D Parihaka seismic data in New Zealand. Applying the weights estimated from training on 3D synthetic volumes to a 3D field data set acc

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Song, Ruo-Long, Jin-Xia Liu, Chun-Hui Hou, and Ke-Xie Wang. "Numerical simulation of Sector Bond log and improved cement bond image." GEOPHYSICS 77, no. 4 (2012): D95—D104. http://dx.doi.org/10.1190/geo2011-0273.1.

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The two principal functions of a primary cement job are to provide support for the casing and to provide hydraulic isolation between zones. A poor cement job may cause many issues during the well production. Therefore, cement bond evaluation is very important in well completion. The Sector Bond log (SBL) has been widely used for cement bond evaluation for years. The SBL tool has eight pairs of directional transmitter-receivers, which are equally distributed in azimuth and used for identifying channels and channel azimuths. To better understand SBL, using a parallel 3D finite difference algorit

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MOUHAT, Stéphanie, Violeta VISAN, S. ANANTHAKRISHNAN, et al. "K+ channel types targeted by synthetic OSK1, a toxin from Orthochirus scrobiculosus scorpion venom." Biochemical Journal 385, no. 1 (2004): 95–104. http://dx.doi.org/10.1042/bj20041379.

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OSK1 (α-KTx3.7) is a 38-residue toxin cross-linked by three disulphide bridges that was initially isolated from the venom of the Asian scorpion Orthochirus scrobiculosus. OSK1 and several structural analogues were produced by solid-phase chemical synthesis, and were tested for lethality in mice and for their efficacy in blocking a series of 14 voltage-gated and Ca2+-activated K+ channels in vitro. In the present paper, we report that OSK1 is lethal in mice by intracerebroventricular injection, with a LD50 (50% lethal dose) value of 2 μg/kg. OSK1 blocks Kv1.1, Kv1.2, Kv1.3 channels potently and

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Hayashi, Koichiro, Ryo Kishida, Akira Tsuchiya, and Kunio Ishikawa. "Channel Aperture Characteristics of Carbonate Apatite Honeycomb Scaffolds Affect Ingrowths of Bone and Fibrous Tissues in Vertical Bone Augmentation." Bioengineering 9, no. 11 (2022): 627. http://dx.doi.org/10.3390/bioengineering9110627.

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Synthetic scaffolds with the ability to prevent fibrous tissue penetration and promote bone augmentation may realize guided bone regeneration without the use of a barrier membrane for dental implantation. Here, we fabricated two types of honeycomb scaffolds of carbonate apatite, a bone mineral analog, whose channel apertures were square (HC-S) and rectangular (HC-R). The side lengths of the HC-Ss and HC-Rs were 265.8 ± 8.9; 817.7 ± 2.4 and 267.1 ± 5.2 μm, respectively. We placed cylindrical HC-Ss and HC-Rs on the rabbit calvaria. At 4 weeks post-implantation, the HC-Ss prevented fibrous tissue

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Swarbrick, Joanna M., Andrew M. Riley, Stephen J. Mills, and Barry V. L. Potter. "Designer small molecules to target calcium signalling." Biochemical Society Transactions 43, no. 3 (2015): 417–25. http://dx.doi.org/10.1042/bst20140293.

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Synthetic compounds open up new avenues to interrogate and manipulate intracellular Ca2+ signalling pathways. They may ultimately lead to drug-like analogues to intervene in disease. Recent advances in chemical biology tools available to probe Ca2+ signalling are described, with a particular focus on those synthetic analogues from our group that have enhanced biological understanding or represent a step towards more drug-like molecules. Adenophostin (AdA) is the most potent known agonist at the inositol 1,4,5-trisphosphate receptor (IP3R) and synthetic analogues provide a binding model for rec

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Kim, Ye-Ji, Yejin Jo, Seung Eun Lee, et al. "Synthetic ShK-like Peptide from the Jellyfish Nemopilema nomurai Has Human Voltage-Gated Potassium-Channel-Blocking Activity." Marine Drugs 22, no. 5 (2024): 217. http://dx.doi.org/10.3390/md22050217.

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We identified a new human voltage-gated potassium channel blocker, NnK-1, in the jellyfish Nemopilema nomurai based on its genomic information. The gene sequence encoding NnK-1 contains 5408 base pairs, with five introns and six exons. The coding sequence of the NnK-1 precursor is 894 nucleotides long and encodes 297 amino acids containing five presumptive ShK-like peptides. An electrophysiological assay demonstrated that the fifth peptide, NnK-1, which was chemically synthesized, is an effective blocker of hKv1.3, hKv1.4, and hKv1.5. Multiple-sequence alignment with cnidarian Shk-like peptide

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PIETRA, FRANCESCO. "DOCKING AND MD SIMULATIONS OF THE INTERACTION OF THE POTASSIUM-SPARING DIURETIC AGENT AMILORIDE WITH THE hASIC1a CHANNEL USING A HOMOLOGY MODEL." Journal of Theoretical and Computational Chemistry 09, no. 01 (2010): 365–78. http://dx.doi.org/10.1142/s0219633610005827.

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The interaction of the K+ -sparing agent amiloride — a synthetic chlorinated pyrimidine derivative — with the hASIC1a ion channel is investigated here along homology modeling of the pore region (using the crystal structure of the cASIC1 channel as a template and the known sequence of hASIC1a), automated docking (using the NMR solution structure of amiloride and its conjugated acid, refined by computations), and molecular dynamics simulations. This represents the first modeling and computational chemistry of the pore region of ASIC/DEG/ENaCs/FaNaCh channels. The results agree with the putative

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Zhong, Jialin, Li Luo, Jiebin Peng, et al. "Dual-Channel Underwater Acoustic Topological Rainbow Trapping Based on Synthetic Dimension." Crystals 14, no. 4 (2024): 311. http://dx.doi.org/10.3390/cryst14040311.

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The concept of “rainbow trapping” has generated considerable interest in wave propagation and energy harvesting, offering new possibilities for diverse and efficient acoustic wave operations. In this work, we investigate a dual-channel topological rainbow trapping device implemented within an underwater two-dimensional phononic crystal based on synthetic dimension. The topological edge states with different frequencies are separated and trapped at different spatial locations. Acoustic waves propagate simultaneously along two boundaries due to the degeneracy of the edge states. In particular, t

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Sifuentes, Caitlin, Harrison K. Martin, Kyle M. Straub, Elizabeth A. Hajek, and Douglas A. Edmonds. "Floodplain topography and avulsion pathfinding control stratigraphic architecture in a numerical model of a fluvial fan." Journal of Sedimentary Research 95, no. 1 (2025): 209–22. https://doi.org/10.2110/jsr.2024.045.

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ABSTRACT Buried channel sand bodies are important reservoirs of subsurface water and energy resources, but their arrangement and interconnectedness are difficult to predict. The dominant process that distributes channels and their sediments in alluvial basins is river avulsion, which occurs when a channel seeks a new location on the adjacent floodplain. Floodplain sedimentation, incision, and channel levee growth influence channel pathfinding during avulsion, and should control key aspects of the stratigraphic arrangement of channel bodies, including compensational (spatially and temporally ev

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Wang, Sue-Lein. "Mesoporous Metal Phosphites with 3D Crystalline Frameworks." Acta Crystallographica Section A Foundations and Advances 70, a1 (2014): C1119. http://dx.doi.org/10.1107/s2053273314088809.

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The synthesis of crystalline porous solids is of great importance in the area of materials chemistry. Naturally occurring zeolites are mostly crystalline; however, they possess pores/channels that only allow small species smaller than 1 nm in diameter to pass through. One exception is the mineral cacoxenite, containing 36-membered ring (36R) channels that allow guest species of up to 1.41 nm in diameter to pass through. In the past, much effort has been devoted to the development of zeolitic materials. Even though multi-faceted design strategies were utilized, the discovery of larger inorganic

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Wan, Li, James Flegle, Burak Ozdoganlar, and Philip LeDuc. "Toward Vasculature in Skeletal Muscle-on-a-Chip through Thermo-Responsive Sacrificial Templates." Micromachines 11, no. 10 (2020): 907. http://dx.doi.org/10.3390/mi11100907.

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Developing new approaches for vascularizing synthetic tissue systems will have a tremendous impact in diverse areas. One area where this is particularly important is developing new skeletal muscle tissue systems, which could be utilized in physiological model studies and tissue regeneration. To develop vascularized approaches a microfluidic on-chip design for creating channels in polymer systems can be pursued. Current microfluidic tissue engineering methods include soft lithography, rapid prototyping, and cell printing; however, these have limitations such as having their scaffolding being in

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Wang, Bowen, Huiyi Hao, Hehe Li, Jinyuan Sun, and Baoguo Sun. "Chinese Baijiu - Finding a channel to design a defined starter culture." Journal of Distilling Science 1, no. 1 (2021): 37–48. http://dx.doi.org/10.61855/jds0101.04.

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Qu (a starter composed of multiple microbes, enzymes, and nutrients) is essential for initiating Chinese baijiu fermentation and is usually prepared in an open system to enrich the starter complex with microorganisms from the local environment. However, with the challenge of increasing manufacturing and labor costs, traditional spontaneous fermentation cannot meet the growing industrial needs for standardization and modernization. Nowadays, the development of a synthetic microbiota built up from selected and cultured microorganisms enables the repeatable, standardized production of fermented f

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Ogurtsova, Ekaterina K., Tatyana N. Makarieva, Yuliya V. Korolkova, et al. "New Derivatives of Natural Acyclic Guanidine Alkaloids with TRPV Receptor-Regulating Properties." Natural Product Communications 10, no. 7 (2015): 1934578X1501000. http://dx.doi.org/10.1177/1934578x1501000708.

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The guanidine alkaloids, dihydropulchranin A (2), prepared from pulchranin A from the sponge Monanchora pulchra, and hexadecylguanidine (3), a synthetic analog of pulchranins, were studied for their TRPV channel-regulating activities. Compound 2 was active as an inhibitor of rTRPV1 and hTRPV3 receptors with EC50 values of 24.3 and 59.1 μM, respectively. Hexadecylguanidine (3) was not active against these receptors.

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Yablokov, A. V., A. S. Serdyukov, and R. A. Efremov. "Method of automated extracting dispersion curves based on time-frequency distribution of seismic data." Russian Journal of Geophysical Technologies, no. 3 (February 21, 2024): 4–16. http://dx.doi.org/10.18303/2619-1563-2023-3-4.

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This paper discusses examples of testing a new implementation of the method of multi-channel surface wave analysis on synthetic data computed for elastic media with complex boundary geometry. The new implementation of the method includes developed algorithms for noise-resistant spectral analysis based on time-frequency domain filtering of seismograms and inversion of dispersion curves of phase velocities based on determination of ranges of possible transverse wave velocity models and application of artificial neural networks. Based on the results of synthetic data processing, the accuracy, lat

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Zahradníková, Alexandra, Jana Pavelková, Miroslav Sabo, Sefer Baday, and Ivan Zahradník. "Structure-based mechanism of RyR channel operation by calcium and magnesium ions." PLOS Computational Biology 21, no. 4 (2025): e1012950. https://doi.org/10.1371/journal.pcbi.1012950.

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Ryanodine receptors (RyRs) serve for excitation-contraction coupling in skeletal and cardiac muscle cells in a noticeably different way, not fully understood at the molecular level. We addressed the structure of skeletal (RyR1) and cardiac (RyR2) isoforms relevant to gating by Ca2+ and Mg2+ ions (M2+). Bioinformatics analysis of RyR structures ascertained the EF-hand loops as the M2+ binding inhibition site and revealed its allosteric coupling to the channel gate. The intra-monomeric inactivation pathway interacts with the Ca2+-activation pathway in both RyR isoforms, and the inter-monomeric p

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Sun, Guangcai, Jixiang Xiang, Mengdao Xing, Jun Yang, and Liang Guo. "A Channel Phase Error Correction Method Based on Joint Quality Function of GF-3 SAR Dual-Channel Images." Sensors 18, no. 9 (2018): 3131. http://dx.doi.org/10.3390/s18093131.

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Multichannel SAR is an effective approach to solving the contradiction between high azimuth resolution and wide swath. The goal of this paper is to obtain a new and effective method for estimating and compensating the interchannel phase error of the Chinese GF-3 Synthetic aperture radar (SAR). A channel phase error correction method based on the optimal value of the image domain quality function is proposed. In this method, the phase error is initially compensated using the correlation function method. In the fine correction of dual-channel phase error, a heuristic search algorithm is used to

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Maddirala, Ajay Kumar, and Kalyana C. Veluvolu. "SSA with CWT and k-Means for Eye-Blink Artifact Removal from Single-Channel EEG Signals." Sensors 22, no. 3 (2022): 931. http://dx.doi.org/10.3390/s22030931.

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Recently, the use of portable electroencephalogram (EEG) devices to record brain signals in both health care monitoring and in other applications, such as fatigue detection in drivers, has been increased due to its low cost and ease of use. However, the measured EEG signals always mix with the electrooculogram (EOG), which are results due to eyelid blinking or eye movements. The eye-blinking/movement is an uncontrollable activity that results in a high-amplitude slow-time varying component that is mixed in the measured EEG signal. The presence of these artifacts misled our understanding of the

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Xu, Duo, Jenna Karcheski, Chi-Yan Law, Ye Zhu, Chia-Jung Hsu, and Jonathan C. Tan. "Exploring Magnetic Fields in Molecular Clouds through Denoising Diffusion Probabilistic Models." Astrophysical Journal 980, no. 1 (2025): 52. https://doi.org/10.3847/1538-4357/ada8a0.

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Abstract Accurately measuring magnetic field strength in the interstellar medium, including giant molecular clouds, remains a significant challenge. We present a machine learning approach using denoising diffusion probabilistic models (DDPMs) to estimate magnetic field strength from synthetic observables such as column density, orientation angles of the dust continuum polarization vector, and line-of-sight (LOS) nonthermal velocity dispersion. We trained three versions of the DDPM model: the 1-channel DDPM (using only column density), the 2-channel DDPM (incorporating both column density and p

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Sherlock, D., G. Weir, and K. Dodds. "ANALOG RESERVOIR MODELLING OF CHANNEL SANDS." APPEA Journal 45, no. 1 (2005): 439. http://dx.doi.org/10.1071/aj04034.

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This paper outlines the results of analog modelling of a sandy deepwater channel reservoir to gain insight into issues of uncertainty in reservoir simulations and their seismic expression. The project is unique in that it integrates seismic and reservoir engineering research in a controlled laboratory environment. Unlike numerical modelling investigations, this laboratory-based modelling study provides real data that does not rely on assumptions and is, therefore, a useful case study for comparing the actual production and seismic response against numerical predictions.The 1 m2 model comprised

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Xu, Wei, Lu Bai, Pingping Huang, Weixian Tan, and Yifan Dong. "A Space-Borne SAR Azimuth Multi-Channel Quantization Method." Electronics 13, no. 6 (2024): 1102. http://dx.doi.org/10.3390/electronics13061102.

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The space-borne synthetic aperture radar (SAR) azimuth multi-channel system has extensive applications because it can achieve high-resolution and wide-swath radar imaging. The thermal noise generated by the radar receiver of each channel during operation will cause an imbalance between channels. If the echoes of each channel are quantized with the same number of bits without considering the influence of thermal noise, false targets will appear in the imaging consequences. Considering that the thermal noise generated in the receiver will affect the quantization process of the space-borne SAR az

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Liang, Zhen, Xikai Fu, and Xiaolei Lv. "New Channel Errors Estimation Method for Multichannel SAR Based on Virtual Calibration Source." Remote Sensing 13, no. 18 (2021): 3625. http://dx.doi.org/10.3390/rs13183625.

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The multichannel synthetic aperture radar (SAR) system can effectively overcome the fundamental limitation between high-resolution and wide-swath. However, the unavoidable channel errors will result in a mismatch of the reconstruction filter and false targets in pairs. To address this issue, a novel channel errors calibration method is proposed based on the idea of minimizing the mean square error (MMSE) between the signal subspace and the space spanned by the practical steering vectors. The practical steering matrix of each Doppler bin can be constructed according to the Doppler spectrum. Com

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Park, Ji-Hoon, Seung-Mo Seo, and Ji-Hee Yoo. "SAR ATR for Limited Training Data Using DS-AE Network." Sensors 21, no. 13 (2021): 4538. http://dx.doi.org/10.3390/s21134538.

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Although automatic target recognition (ATR) with synthetic aperture radar (SAR) images has been one of the most important research topics, there is an inherent problem of performance degradation when the number of labeled SAR target images for training a classifier is limited. To address this problem, this article proposes a double squeeze-adaptive excitation (DS-AE) network where new channel attention modules are inserted into the convolutional neural network (CNN) with a modified ResNet18 architecture. Based on the squeeze-excitation (SE) network that employs a representative channel attenti

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Li, Hongyu, Hennie Valkenier, Abigail G. Thorne, et al. "Anion carriers as potential treatments for cystic fibrosis: transport in cystic fibrosis cells, and additivity to channel-targeting drugs." Chemical Science 10, no. 42 (2019): 9663–72. http://dx.doi.org/10.1039/c9sc04242c.

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Chen, Yibin, Liang Li, Guikun Liu, and Zhengshuai Li. "Performance of an Effective SAR Polarimetric Calibration Method Using Polarimetric Active Radar Calibrators: Numerical Simulations and LT-1 Experiments." Remote Sensing 17, no. 4 (2025): 584. https://doi.org/10.3390/rs17040584.

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This paper presents a new approach to polarimetric calibration, extending classical PARC-based methods by exploring new matrix combinations that broaden the applicability of the existing techniques. By investigating alternative matrix configurations, the proposed method not only enhances the flexibility of conventional calibration approaches but also identifies matrix combinations that offer superior performance advantages. The influence of the SNR and scattering matrix error of PARC on the proposed method is evaluated by numerical simulations. The results demonstrate that the proposed method

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Yanai, Takuma, Takatomo Ouchi, Masumi Yamada, and Minoru Seki. "Hydrodynamic Microparticle Separation Mechanism Using Three-Dimensional Flow Profiles in Dual-Depth and Asymmetric Lattice-Shaped Microchannel Networks." Micromachines 10, no. 6 (2019): 425. http://dx.doi.org/10.3390/mi10060425.

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We herein propose a new hydrodynamic mechanism of particle separation using dual-depth, lattice-patterned asymmetric microchannel networks. This mechanism utilizes three-dimensional (3D) laminar flow profiles formed at intersections of lattice channels. Large particles, primarily flowing near the bottom surface, frequently enter the shallower channels (separation channels), whereas smaller particles flowing near the microchannel ceiling primarily flow along the deeper channels (main channels). Consequently, size-based continuous particle separation was achieved in the lateral direction in the

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Zhang, Lei, Yunkai Deng, and Robert Wang. "Channel Phase Error Compensation for MIMO-SAR." International Journal of Antennas and Propagation 2014 (2014): 1–7. http://dx.doi.org/10.1155/2014/798673.

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Multi-input multioutput (MIMO) is a novel technique to achieve high-resolution as well as wide swath in synthetic aperture radar (SAR) systems. Channel imbalance is inevitable in multichannel systems that it declines the imaging quality. Generally, the imbalance cannot be fully compensated by simple internal calibration in a MIMO-SAR system. In this paper, a new algorithm based on raw data is presented to remove the channel phase error. Based on the error source, this approach models the phase error as two parts: the transmit phase error and the receive phase error. The receive phase error is

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Yuan, Hongyi, Nianen Zhang, Hongyu Zhang, and Cuicui Lu. "A Multi-Channel Frequency Router Based on an Optimization Algorithm and Dispersion Engineering." Nanomaterials 13, no. 14 (2023): 2133. http://dx.doi.org/10.3390/nano13142133.

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Integrated frequency routers, which can guide light with different frequencies to different output ports, are an important kind of nanophotonic device. However, frequency routers with both a compact size and multiple channels are difficult to realize, which limits the application of these frequency routers in nanophotonics. Here, a kind of bandgap optimization algorithm, which consists of the finite element method and topology optimization, is proposed to design a multi-channel frequency router. Channels supporting photonic edge states with different frequencies are built through the synthetic

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Dalpozzo, Renato. "The Synthesis and Use of BMS 204352 (MaxiPostTM)." Mini-Reviews in Organic Chemistry 17, no. 1 (2020): 67–73. http://dx.doi.org/10.2174/1570193x16666181228100254.

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MaxiPostTM is an interesting 3-fluorooxindole derivative, discovered in the late nineties of the last century as potassium channel opener. Since then, two different research fields were discovered: the discovery of new synthetic methods, especially asymmetric ones, and the in vitro and in vivo tests for its use as a drug for different diseases. This mini-review aims to summarize the state of art in both fields.

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Lu, Jing, Qiang Zhang, Jialu Cao, and Hui Tian. "DDFNet: A Dual-Domain Fusion Network for Robust Synthetic Speech Detection." Big Data and Cognitive Computing 9, no. 3 (2025): 58. https://doi.org/10.3390/bdcc9030058.

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The detection of synthetic speech has become a pressing challenge due to the potential societal risks posed by synthetic speech technologies. Existing methods primarily focus on either the time or frequency domain of speech, limiting their ability to generalize to new and diverse speech synthesis algorithms. In this work, we present a novel and scientifically grounded approach, the Dual-domain Fusion Network (DDFNet), which synergistically integrates features from both the time and frequency domains to capture complementary information. The architecture consists of two specialized single-domai

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Gulina, Yulia, Jiaqi Zhu, George Krasin, Evgeny Kuzmin, and Sergey Kudryashov. "Numerical Aperture-Dependent Spatial Scaling of Plasma Channels in HPHT Diamond." Photonics 10, no. 10 (2023): 1177. http://dx.doi.org/10.3390/photonics10101177.

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The investigation of plasma channels induced by focused ultra-short 1030-nm laser pulses in bulk of synthetic High Pressure High Temperature (HPHT) diamond revealed strong dependence of their spatial parameters on the used numerical aperture of the lens (NA = 0.15–0.45). It was shown that at weak focusing conditions it is possible to significantly increase the length of the plasma channel with a slight increase in pulse power, while tight focusing allows one to obtain more compact structures in the same range of used powers. Such a dependence paves the way to new possibilities in 3D processing

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Wang, Dan, Pratik Neupane, Lotten Ragnarsson, Robert Capon, and Richard Lewis. "Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels." Membranes 12, no. 8 (2022): 749. http://dx.doi.org/10.3390/membranes12080749.

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The natural product indole-3-carbinol (I3C) and its major digestive product 3,3′-diindolylmethane (DIM) have shown clinical promise in multiple forms of cancer including breast cancer. In this study, we explored the calcium channel activity of DIM, its synthetic derivative 3,3’-Diindolylmethanone (DIM-one) and related I3C and DIM-one analogs. For the first time, DIM, DIM-one and analog IX were identified as selective blockers for T-type CaV3.3 (IC50s DIM 2.09 µM; DIM-one 9.07 µM) while compound IX inhibited both CaV3.2 (6.68 µM) and CaV3.3 (IC50 = 3.05 µM) using a FLIPR cell-based assay to mea

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Ho, Anh-Dung, and Huong-Giang Doan. "Quantitation of new arbitrary view dynamic human action recognition framework." Indonesian Journal of Electrical Engineering and Computer Science 37, no. 3 (2025): 1797. https://doi.org/10.11591/ijeecs.v37.i3.pp1797-1803.

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<p>Dynamic action recognition has attracted many researchers due to its applications. Nevertheless, it is still a challenging problem because the diversity of camera setups in the training phases are not similar to the testing phases, and/or the arbitrary view actions are captured from multiple viewpoints of cameras. In fact, some recent dynamic gesture approaches focus on multiview action recognition, but they are not resolved in novel viewpoints. In this research, we propose a novel end-to-end framework for dynamic gesture recognition from an unknown viewpoint. It consists of three mai

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Anh-Dung, Ho Huong-Giang Doan. "Quantitation of new arbitrary view dynamic human action recognition framework." Indonesian Journal of Electrical Engineering and Computer Science 37, no. 3 (2025): 1797–803. https://doi.org/10.11591/ijeecs.v37.i3.pp1797-1803.

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Dynamic action recognition has attracted many researchers due to its applications. Nevertheless, it is still a challenging problem because the diversity of camera setups in the training phases are not similar to the testing phases, and/or the arbitrary view actions are captured from multiple viewpoints of cameras. In fact, some recent dynamic gesture approaches focus on multiview action recognition, but they are not resolved in novel viewpoints. In this research, we propose a novel end-to-end framework for dynamic gesture recognition from an unknown viewpoint. It consists of three main compone

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Carullo, Gabriele, Simona Saponara, Amer Ahmed, et al. "Novel Labdane Diterpenes-Based Synthetic Derivatives: Identification of a Bifunctional Vasodilator That Inhibits CaV1.2 and Stimulates KCa1.1 Channels." Marine Drugs 20, no. 8 (2022): 515. http://dx.doi.org/10.3390/md20080515.

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Sesquiterpenes such as leucodin and the labdane-type diterpene manool are natural compounds endowed with remarkably in vitro vasorelaxant and in vivo hypotensive activities. Given their structural similarity with the sesquiterpene lactone (+)-sclareolide, this molecule was selected as a scaffold to develop novel vasoactive agents. Functional, electrophysiology, and molecular dynamics studies were performed. The opening of the five-member lactone ring in the (+)-sclareolide provided a series of labdane-based small molecules, promoting a significant in vitro vasorelaxant effect. Electrophysiolog

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Seydi, Seyd Teymoor, Mahdi Hasanlou, and Meisam Amani. "A New End-to-End Multi-Dimensional CNN Framework for Land Cover/Land Use Change Detection in Multi-Source Remote Sensing Datasets." Remote Sensing 12, no. 12 (2020): 2010. http://dx.doi.org/10.3390/rs12122010.

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The diversity of change detection (CD) methods and the limitations in generalizing these techniques using different types of remote sensing datasets over various study areas have been a challenge for CD applications. Additionally, most CD methods have been implemented in two intensive and time-consuming steps: (a) predicting change areas, and (b) decision on predicted areas. In this study, a novel CD framework based on the convolutional neural network (CNN) is proposed to not only address the aforementioned problems but also to considerably improve the level of accuracy. The proposed CNN-based

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Lu, Zekun, A. Lazarian, and Dmitri Pogosyan. "Producing synthetic maps of dust polarization using a velocity channel gradient technique." Monthly Notices of the Royal Astronomical Society 496, no. 3 (2020): 2868–84. http://dx.doi.org/10.1093/mnras/staa1570.

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ABSTRACT In modern cosmology, many efforts have been made to detect the primordial B-mode of cosmic microwave background polarization from gravitational waves generated during inflation. Considering the foreground dust contamination of microwave polarization maps, it is essential to obtain a precise prediction for polarization in dust emission. In this work, we show a new method to produce synthetic maps of dust polarization in the magnetized turbulent interstellar medium from more abundant high-resolution H i data. By using the velocity channel gradient technique, we are able to predict both

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Haworth, Christopher. "Ear as Instrument." Leonardo Music Journal 22 (December 2012): 61–62. http://dx.doi.org/10.1162/lmj_a_00099.

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The desire for instrumental qualities in computer music often leads the artist to a process of “synthetic limitation,” wherein constraint is designed into a performance system, permitting creation only within prescribed limits. These practices can emerge as a consequence of the sheer dearth of possibilities available to the digital artist: as though the path to new sounds and ever more intimate control leads ultimately to a retreat. The author's response to this perennial dilemma has been to try to discover instrumental limitations within the ear itself. He describes an “ear-as-instrument” app

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Abdul Chalid, Rury Rofyan, and Prasoni Agung. "The Flood Analysis with HEC-RAS a Case Study of Muarojambi River Basin." Jurnal Teknik Sipil dan Perencanaan 26, no. 2 (2024): 46–58. https://doi.org/10.15294/jtsp.v26i2.4640.

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This study aims to determine how wide the catchment area is on the Melayu and Jambi rivers, how much the planned flood discharge is at a return period of 2, 5, 10, 25, and 50 years with the Nakayasu Synthetic Unit Hydrograph (SUH) Analyze the water level of these rivers downstream at the planned flood discharge conditions due to backwater from the Jambi river. This also plans the cross-sectional area and length of the Jambi River as a new channel to the Batanghari River using the HECRAS model. The result shows that the Melayu River can still serve a water level of 10 for a 10-year return perio

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LEBRUN, Bruno, Régine ROMI-LEBRUN, Marie-France MARTIN-EAUCLAIRE, et al. "A four-disulphide-bridged toxin, with high affinity towards voltage-gated K+ channels, isolated from Heterometrus spinnifer (Scorpionidae) venom." Biochemical Journal 328, no. 1 (1997): 321–27. http://dx.doi.org/10.1042/bj3280321.

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A new toxin, named HsTX1, has been identified in the venom of Heterometrus spinnifer (Scorpionidae), on the basis of its ability to block the rat Kv1.3 channels expressed in Xenopus oocytes. HsTX1 has been purified and characterized as a 34-residue peptide reticulated by four disulphide bridges. HsTX1 shares 53% and 59% sequence identity with Pandinus imperator toxin1 (Pi1) and maurotoxin, two recently isolated four-disulphide-bridged toxins, whereas it is only 32-47% identical with the other scorpion K+ channel toxins, reticulated by three disulphide bridges. The amidated and carboxylated for

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Kim, Changwon. "Region Adaptive Single Image Dehazing." Entropy 23, no. 11 (2021): 1438. http://dx.doi.org/10.3390/e23111438.

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Image haze removal is essential in preprocessing for computer vision applications because outdoor images taken in adverse weather conditions such as fog or snow have poor visibility. This problem has been extensively studied in the literature, and the most popular technique is dark channel prior (DCP). However, dark channel prior tends to underestimate transmissions of bright areas or objects, which may cause color distortions during dehazing. This paper proposes a new single-image dehazing method that combines dark channel prior with bright channel prior in order to overcome the limitations o

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Pham, Nam, and Sergey Fomel. "Uncertainty and interpretability analysis of encoder-decoder architecture for channel detection." GEOPHYSICS 86, no. 4 (2021): O49—O58. http://dx.doi.org/10.1190/geo2020-0409.1.

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We have adopted a method to understand uncertainty and interpretability of a Bayesian convolutional neural network for detecting 3D channel geobodies in seismic volumes. We measure heteroscedastic aleatoric uncertainty and epistemic uncertainty. Epistemic uncertainty captures the uncertainty of the network parameters, whereas heteroscedastic aleatoric uncertainty accounts for noise in the seismic volumes. We train a network modified from U-Net architecture on 3D synthetic seismic volumes, and then we apply it to field data. Tests on 3D field data sets from the Browse Basin, offshore Australia,

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