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Dissertations / Theses on the topic 'New variant'

Author: Grafiati

Published: 25 May 2024

Last updated: 19 July 2025

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1

Suhanyiova, Lucia. "Product safety culture : a new variant of safety culture?" Thesis, University of Aberdeen, 2018. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=238033.

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Parkinson, Jonathan R. "Optimizing product variant placement to satisfy market demand /." Diss., CLICK HERE for online access, 2007. http://contentdm.lib.byu.edu/ETD/image/etd1805.pdf.

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3

Zeidler, Martin. "A new variant of Creutzfeldt-Jakob disease in the United Kingdom." Thesis, University of Southampton, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.274425.

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Mason, Nicole Marie. "A test of the new variant famine hypothesis panel survey evidence from Zambia /." Diss., Connect to online resource - MSU authorized users, 2008.

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5

Xia, Yang. "The localisation and regulation of phosphatidylinositol-4-phosphate 5-Kinase gamma splice variants and the discovery of a new mammalian splice variant, PIP5KIγ_v6". Thesis, University of Cambridge, 2011. https://www.repository.cam.ac.uk/handle/1810/240633.

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Type I PIP kinases (phosphatidylinositol 4-phosphate 5-kinases, PIP5Ks) catalyse the majority of cellular synthesis of PI(4,5)P2. To date, three mammalian isoforms (r1, r2, r3) have been found. PIP5KIr is subject to complex C-terminal splice variation, enhancing its transcriptional diversity through evolution and producing at least 5 known spliceoforms in the mammals. This study addresses several important questions. (1) Several remarkable differences have been discovered between the neuronal splice variant PIP5KIr_i3 and its close variant, Ir_i2, whose peptide lacks a 26-AA insert near its C-

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Vignos, Megan C. "A HISTOPATHOLOGICAL AND MAGNETIC RESONANCE IMAGING ASSESSMENT OF MYELOCORTICAL MULTIPLE SCLEROSIS: A NEW PATHOLOGICAL VARIANT." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1461528682.

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Willet, Cali Elizabeth. "Applications of New and Emerging Genomic Technologies to Animal Genetics." Thesis, The University of Sydney, 2015. http://hdl.handle.net/2123/14381.

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Recent technological advances have revolutionised the conduct of animal genetics. Refinements to high‐throughput genotyping and sequencing platforms have brought these technologies within reach of animal geneticists, providing exciting research opportunities. Yet to apply them experimentally at the scale benchmarked by human genetics studies remains financially prohibitive for most animal genetics projects. Limited opportunities for funding along with restricted sampling due to animal ethics constraints or rarity of the trait combine to effect low‐powered datasets. This thesis explores methods

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PLUMITALLO, SARA. "Hereditary Haemorrhagic Telangiectasia: mutation analysis, new variant characterization and study of circulating microRNAs in a rare disease." Doctoral thesis, Università degli studi di Pavia, 2017. http://hdl.handle.net/11571/1203306.

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The topic of my PhD project is the Hereditary Haemorrhagic Telangiectasia (HHT), also known as Rendu-Osler-Weber syndrome, a rare genetic disease with an incidence of about 1:5000, inherited as an autosomal dominant trait. Up to date, mutations in four genes (ENG, ACVRL1, MADH4 and GDF2) have been described in HHT, however, ENG and ACVRL1 mutations account for the 85% of patients. All these genes encode for proteins belonging to the TGF-β/BMPs signalling pathway and are involved in the regulation of angiogenesis. HHT is clinically diagnosed if a patient presents at least three out of four crit

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Harrison, Sandra. "Staff and pupil experience and perceptions : what is seen as the 'value' of a new variant nurture group?" Thesis, University of Newcastle upon Tyne, 2016. http://hdl.handle.net/10443/3471.

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Nurture Groups have experienced rises and falls in popularity since their initial introduction by Marjorie Boxall in 1969 in inner city London (Boxall 1976). At present there are more than 1,500 Nurture Groups in the UK (Nurture Group Network Website) with the Nurture Group Network continuing work to expand and develop the use of these groups in more areas across the country. This research project seeks first to examine the effectiveness or success of nurture groups in preparing children for reintroduction to the mainstream classroom. This was examined by conducting a systematic review of the

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Purcell, Christina. "Temporary agency workers in the French car industry : working under a new variant of 'despotism' in the labour process." Thesis, Manchester Metropolitan University, 2014. http://e-space.mmu.ac.uk/332118/.

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This thesis is an exploration of how the use of temporary agency work in French car plants modifies the experience and mechanisms of labour control in the labour process. Over the last decade, car manufacturers in France have made extensive use of this form of employment, despite regulations which restrict the use of agency labour to exceptional circumstances. Legal challenges aimed at reclassifying temporary agency contracts into permanent employment contracts have revealed that some agency workers have accumulated many years of employment as an agency worker with user-company. The presence o

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Zink, Lisa-Maria [Verfasser], and Sandra [Akademischer Betreuer] Hake. "Unraveling deposition mechanism and function of a new histone H3 variant H3.Y / Lisa-Maria Zink ; Betreuer: Sandra Hake." München : Universitätsbibliothek der Ludwig-Maximilians-Universität, 2017. http://d-nb.info/1144177987/34.

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Favero, Francesco. "Development of two new approaches for NGS data analysis of DNA and RNA molecules and their application in clinical and research fields." Doctoral thesis, Università del Piemonte Orientale, 2019. http://hdl.handle.net/11579/102446.

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The aim of this study is focused on two main areas of NGS analysis data: RNA-seq(with a specific interest in meta-transcriptomics) and DNA somatic mutations detection. We developed a simple and efficient pipeline for the analysis of NGS data derived from gene panels to identify DNA somatic point mutations. In particular we optimized a somatic variant calling procedure that was tested on simulated datasets and on real data. The performance of our system has been compared with currently available tools for variant calling reviewed in literature. For RNA-seq analysis, in this work we tested and o

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Papadopoulos, Chrisovalantis [Verfasser]. "Identification and characterization of a new splice variant of the protein kinase DYRK4 and the role of DYRK1A during mitotic exit / Chrisovalantis Papadopoulos." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2011. http://d-nb.info/1018202714/34.

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Fairclough, Rebecca J. "Effect of Hailey-Hailey disease mutations on the function of a new variant of human secretory pathway CaÂ²âº/MnÂ²âº-ATPase (hSPCA1)." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.275321.

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Christerson, Linus. "High Resolution Genotyping of Chlamydia trachomatis." Doctoral thesis, Uppsala universitet, Klinisk bakteriologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-156751.

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Chlamydia trachomatis is an obligate intracellular bacterium of major human health concern, causing urogential chlamydia infections, lymphogranuloma venereum (LGV) and trachoma. Chlamydia is one of the most common sexually transmitted infections worldwide and can cause infertility. In the first four papers described herein we used a high resolution multilocus sequence typing (MLST) system to investigate the epidemiology of C. trachomatis, and showed that MLST is superior to conventional ompA genotyping with respect to resolution. In the fifth paper we simplified the methodology by developing a

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Rego, Campello Hugo. "New synthetic methodology directed towards novel cytisine variants." Thesis, University of Bristol, 2016. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.761204.

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Hur, Chang Soo. "Variance bound test : a new approach." The Ohio State University, 1985. http://rave.ohiolink.edu/etdc/view?acc_num=osu1269522789.

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Adámek, Vojtěch. "Porovnání investičních variant rekreačního zařízení Eden Jinolice." Master's thesis, Vysoká škola ekonomická v Praze, 2016. http://www.nusl.cz/ntk/nusl-261766.

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This thesis deals with the issue of investment decision. The goal of thesis is to evaluate for the company owners optimal investment variant of predetermined investment opportunities. Thesis is divided into theoretical-methodological part, which summarizes all the methods and procedures and practical part. The practical part consists mainly of net present value calculations, which chosen input data will be afterwards analyzed by sensitivity test. Application of these apparatuses will reveal the best investment opportunity, respectively their combination

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Ueda, Yoshihide. "New p73 variants with altered C-terminal structures have varied transcriptional activities." Kyoto University, 2001. http://hdl.handle.net/2433/150540.

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FONTANA, GIORGIA. "FUNCTIONAL ANALYSIS OF NEW GENETIC VARIANTS IDENTIFIED IN GENES OF INHERITED THROMBOCYTOPENIA." Doctoral thesis, Università degli Studi di Trieste, 2021. http://hdl.handle.net/11368/2983831.

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Inherited thrombocytopenias (IT) are a group of rare diseases characterized by a low platelet count (less than 150.000 / mL) and high degree of heterogeneity at both clinical and genetic point of view. To date, mutations in at least 30 different genes have been identified, however about 50% of patients still remain without molecular diagnosis, due to the complexity of the diagnostic framework and because many patients are probably affected by forms of IT not characterized yet. The spread in the last decade of next generation sequencing techniques (Next Generation Sequencing, NGS) allow us to s

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GANDIN, ILARIA. "Research and identfication of new genes and pathogenetic variants involved in Intellectual Disability." Doctoral thesis, Università degli Studi di Trieste, 2016. http://hdl.handle.net/11368/2908005.

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Intellectual Disability (ID) is one of the most common neurodevelopmental disorders, affecting between 1.5-2% of individuals in the general population. This pathology has a serious impact on the affected individuals, their families and also on the health care system. Understanding the genetic mechanisms implicated in the disease is challenging, since ID includes a wide spectrum of possible underlying disorders and the genetic variants determining the disease are highly heterogeneous, requiring the application of different approaches and techniques, from cytogenetic analysis to the application

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22

Samples, Gil L. "Greek texts and English translations of the Bible: a comparison and contrast of the Textus Receptus Greek New Testament of the sixteenth century and the Alexandrian text of Westcott and Hort (nineteenth century) and Aland and Metzger (twentieth century) concerning variant texts that pertain to the orthodox Christology of the Council of Nicea, A.D. 325." Thesis, University of North Texas, 2002. https://digital.library.unt.edu/ark:/67531/metadc3315/.

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The argument of this paper is that certain salient passages in the New Testament concerning Christology, as it was defined in the Nicene creed in A.D. 325, reflect such orthodoxy better in the Textus Receptus Greek texts and the English translations made from them than do the Alexandrian texts. Arian theology, which was condemned as heretical at Nicea, is examined. Patristic quotations, historical texts, and arguments of the scholars are cited and traced, along with a comparison of Christological verses.

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Jary, Aude. "Déterminants moléculaires et cliniques de l’infection par l’herpèsvirus humain 8 : facteurs impliqués dans la transmission du HHV-8 et le développement des maladies associées." Electronic Thesis or Diss., Sorbonne université, 2020. http://www.theses.fr/2020SORUS332.

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L'herpèsvirus humain 8 (HHV-8) est impliqué dans toutes les formes de maladie de Kaposi (MK) mais également dans certaines formes de maladie de Castleman multicentrique (MCM) et dans le lymphome primitif des séreuses (LPS). Ce travail avait pour objectif d’étudier les déterminants cliniques et virologiques impliqués dans l’infection HHV-8 et les maladies qui lui sont liées. Ainsi dans l’étude 1, la charge virale HHV-8 associée à la MK était inférieure à celles retrouvées dans les hémopathies, probablement dû à la physiopathologie de chaque maladie, mais d’autres facteurs pourraient également i

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Lazic, Jasmina. "New variants of variable neighbourhood search for 0-1 mixed integer programming and clustering." Thesis, Brunel University, 2010. http://bura.brunel.ac.uk/handle/2438/4602.

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Many real-world optimisation problems are discrete in nature. Although recent rapid developments in computer technologies are steadily increasing the speed of computations, the size of an instance of a hard discrete optimisation problem solvable in prescribed time does not increase linearly with the computer speed. This calls for the development of new solution methodologies for solving larger instances in shorter time. Furthermore, large instances of discrete optimisation problems are normally impossible to solve to optimality within a reasonable computational time/space and can only be tackl

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Jafeth, Villasana Tinajero Pedro. "New Variants of Nonnegative Matrix Factorization with Application to Speech Coding and Speech Enhancement." Thesis, KTH, Skolan för elektroteknik och datavetenskap (EECS), 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-253264.

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In this thesis, new variants of nonnegative matrix factorization (NMF) based ona convolutional data model, -divergence and sparsication are developed andanalyzed. These NMF variants are collectively referred to as -CNMF. Commonsparsication techniques such as L1-norm minimization and elastic net arediscussed and a new regularizer is proposed. It is shown that the new regularizer,unlike the above-mentioned sparsication techniques, has control overthe number of active bases in the NMF dictionary. Moreover, the -CNMF isextended to multichannel signals: it learns a common dictionary by exploitingth

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Aruchunan, Elayaraja. "The New Variants of Modified Weighted Mean Iterative Methods for Fredholm Integro-Differential Equations." Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/57125.

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In this research, the Modified Weighted Mean iterative methods are developed and investigated for solving Integro-differential equations of Fredholm type. The developed methods are further investigated by implementing computational complexity-reduction techniques on three combination sets of Central Difference-Composite Closed Newton-Cotes dense systems. All new variants of proposed methods are presented with strong convergence theorems and proofs. The effectiveness and efficiency of the methods are investigated and validated with some existing methods, and via vigorous numerical analysis.

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DIODATO, DARIA. "Identification and functional validation of new mtDNA and nuclear gene variants responsible for mitochondrial disorders." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50549.

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My project has been focused on the identification and validation of new mitochondrial gene variants and new mitochondria-related genes. The first report is about a woman presenting with a stroke-like episode and an history of severe hearing loss, frequent migraines, exercise intolerance, myalgias and limb-girdle muscle weakness indicating a slowly progressive myopathy and secondary amenorrhea with low gonadotropin levels. A muscle biopsy showed ragged-red, cytochrome c oxidase-negative fibers, and an isolated defect of cytochrome c oxidase activity in muscle mitochondria and sequence analysi

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Fischer, Carsten Oliver [Verfasser]. "New Results on the Probabilistic Analysis of Online Bin Packing and its Variants / Carsten Oliver Fischer." Bonn : Universitäts- und Landesbibliothek Bonn, 2019. http://d-nb.info/120172791X/34.

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Lomartire, Silvia <1987&gt. "Analysis of Copy Number Variants identifies new candidate genes for Autism Spectrum Disorder and Intellectual Disability." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7111/1/Lomartire_Silvia_Tesi.pdf.

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Autism spectrum disorder (ASD) and Intellectual Disability (ID) are complex neuropsychiatric disorders characterized by extensive clinical and genetic heterogeneity and with overlapping risk factors. The aim of my project was to further investigate the role of Copy Numbers Variants (CNVs), identified through genome-wide studies performed by the Autism Geome Project (AGP) and the CHERISH consortium in large cohorts of ASD and ID cases, respectively. Specifically, I focused on four rare genic CNVs, selected on the basis of their impact on interesting ASD/ID candidate genes: a) a compound hete

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Lomartire, Silvia <1987&gt. "Analysis of Copy Number Variants identifies new candidate genes for Autism Spectrum Disorder and Intellectual Disability." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amsdottorato.unibo.it/7111/.

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Autism spectrum disorder (ASD) and Intellectual Disability (ID) are complex neuropsychiatric disorders characterized by extensive clinical and genetic heterogeneity and with overlapping risk factors. The aim of my project was to further investigate the role of Copy Numbers Variants (CNVs), identified through genome-wide studies performed by the Autism Geome Project (AGP) and the CHERISH consortium in large cohorts of ASD and ID cases, respectively. Specifically, I focused on four rare genic CNVs, selected on the basis of their impact on interesting ASD/ID candidate genes: a) a compound hete

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Åberg, K. Magnus. "Variance Reduction in Analytical Chemistry : New Numerical Methods in Chemometrics and Molecular Simulation." Doctoral thesis, Stockholm University, Department of Analytical Chemistry, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-283.

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<p>This thesis is based on five papers addressing variance reduction in different ways. The papers have in common that they all present new numerical methods.</p><p>Paper I investigates quantitative structure-retention relationships from an image processing perspective, using an artificial neural network to preprocess three-dimensional structural descriptions of the studied steroid molecules.</p><p>Paper II presents a new method for computing free energies. Free energy is the quantity that determines chemical equilibria and partition coefficients. The proposed method may be used for estimating

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Åberg, K. Magnus. "Variance reduction in analytical chemistry : new numerical methods in chemometrics and molecular simulation /." Stockholm : Institutionen för analytisk kemi, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-283.

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Thieulent, Côme. "Criblage in vitro de molécules antivirales contre l'herpèsvirus équin-1 par impédancemétrie et évaluation clinique de l'effet du valganciclovir Screening and evaluation of antiviral compounds against Equid alpha-herpesviruses using an impedance-based cellular assay Identification of antiviral compounds against equid herpesvirus-1 using real-time cell assay screening: Efficacy of decitabine and valganciclovir alone or in combination Screening of potential antiviral molecules against equid herpesvirus-1 using cellular impedance measurement: dataset of 2,891 compounds New EHV-1 variant identified | Veterinary Recordvir réduit les signes cliniques, l'excrétion virale et la virémie chez des poneys infectés expérimentalement par la nouvelle souche C2254 d'herpèsvirus équin 1 Oral administration of valganciclovir reduces clinical signs, virus sheedind and cell-associated viremia in ponies experimentally infected with the new variant C2254 of equid herpesvirus-1." Thesis, Normandie, 2020. http://www.theses.fr/2020NORMC421.

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Neuf herpèsvirus sont connus pour infecter les équidés. Parmi eux, l’herpèsvirus équin 1 (HVE-1) induit les formes de la maladie les plus graves. En effet, ce virus provoque des troubles respiratoires, des avortements, des morts néonatales et des troubles nerveux qui mènent souvent à l’euthanasie de l’animal. La prophylaxie, reposant sur les bonnes pratiques sanitaires et la vaccination, demeure le meilleur moyen de lutte contre l’ensemble des herpèsvirus équins. Des vaccins qui réduisent efficacement les troubles respiratoires et la dissémination de l’HVE-1 ont été développés. Cependant, ces

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Ceroni, Fabiola <1985&gt. "Investigating the role of Copy Number Variants in Specific Language Impairment and identification of new candidate genes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6409/1/Ceroni_Fabiola_tesi.pdf.

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Specific language impairment (SLI) is a complex neurodevelopmental disorder defined as an unexpected failure to develop normal language abilities for no obvious reason. Copy number variants (CNVs) are an important source of variation in the susceptibility to neuropsychiatric disorders. Therefore, a CNV study within SLI families was performed to investigate the role of structural variants in SLI. Among the identified CNVs, we focused on CNVs on chromosome 15q11-q13, recurrently observed in neuropsychiatric conditions, and a homozygous exonic microdeletion in ZNF277. Since this microdeletion fal

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Ceroni, Fabiola <1985&gt. "Investigating the role of Copy Number Variants in Specific Language Impairment and identification of new candidate genes." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2014. http://amsdottorato.unibo.it/6409/.

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Specific language impairment (SLI) is a complex neurodevelopmental disorder defined as an unexpected failure to develop normal language abilities for no obvious reason. Copy number variants (CNVs) are an important source of variation in the susceptibility to neuropsychiatric disorders. Therefore, a CNV study within SLI families was performed to investigate the role of structural variants in SLI. Among the identified CNVs, we focused on CNVs on chromosome 15q11-q13, recurrently observed in neuropsychiatric conditions, and a homozygous exonic microdeletion in ZNF277. Since this microdeletion fal

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36

Špačková, Sára. "Variantní řešení investiční výstavby." Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-409909.

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The thesis deals with the evalutation, which of the variants of the project investment is the most advantageous to the developer. The thesis is divided to the theoretical and practical part. The theoretical part is dedicaded to the explanation of terms associated with the investment, the investment project, the price determination and valuation of the real estates. There are also explained the terms related to the development projects and the real estate market. At last but not least, the theoretical part clarifies, how is the tax burden applicated to the practical part. The practical part is

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Chernoglazov, Alexander Igorevich. "Improving Visualisation of Large Multi-Variate Datasets: New Hardware-Based Compression Algorithms and Rendering Techniques." Thesis, University of Canterbury. Computer Science and Software Engineering, 2012. http://hdl.handle.net/10092/7004.

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Spectral computed tomography (CT) is a novel medical imaging technique that involves simultaneously counting photons at several energy levels of the x-ray spectrum to obtain a single multi-variate dataset. Visualisation of such data poses significant challenges due its extremely large size and the need for interactive performance for scientific and medical end-users. This thesis explores the properties of spectral CT datasets and presents two algorithms for GPU-accelerated real-time rendering from compressed spectral CT data formats. In addition, we describe an optimised implementation of a v

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James, Emma. "Analysis of new members of the costimulatory family of immunoregulatory proteins : common variants and their roles in immune pathologies." Thesis, University of Oxford, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.403743.

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Meneghini, Luca. "Le varianti dell'Apocalisse - Le tre edizioni di Apocalypse Now di Francis Ford Coppola." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amslaurea.unibo.it/25328/.

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Uno studio filologico condotto sulle tre edizioni di Apocalypse Now di Francis Ford Coppola e delle rispettive varianti, e di come esse influiscano sul messaggio filmico partendo dalla letteratura di riferimento.

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Hörmann, Wolfgang. "New generators of normal and Poisson deviates based on the transformed rejection method." Institut für Statistik und Mathematik, Abt. f. Angewandte Statistik u. Datenverarbeitung, WU Vienna University of Economics and Business, 1992. http://epub.wu.ac.at/1532/1/document.pdf.

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The transformed rejection method uses inversion to sample from the dominating density of a rejection algorithm. But in contrast to the usual method it is enough to know the inverse distribution function F^(-1)(x) of the dominating density. This idea can be applied to various continuous (e.g. normal, Cauchy and exponential) and discrete (e.g. binomial and Poisson) distributions with high acceptance probabilities. The resulting algorithms are short, simple and fast. Even more important is the fact that the quality of the method when used in combination with a linear congruential uniform generato

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Croce, Roberta. "Identification of new variants in patients with neurodegenerative disorders by whole genome sequencing data and development of a bioinformatic pipeline." Doctoral thesis, Università del Piemonte Orientale, 2021. http://hdl.handle.net/11579/127934.

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We explored the missing heritability in a cohort of 140 patients affected by Neurodegenerative disorders (NDDs), including Amyotrophic Lateral Sclerosis (ALS), Frontotemporal dementia (FTD)) Parkinson disease (PD) and Spinocerebellar Ataxia (SCA). We performed Whole Genome Sequencing (WGS) after excluding pathogenic variants in the main disease-relevant causative genes and investigated 3 classes of potentially pathogenic variants: a)Coding/non-coding SNV/Indels in a panel of 696 genes involved in NODs. Using standard annotation, we identified pathogenic/likely pathogenic variants (ACMG) in gen

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Flores, de Valgas Torres Fernando Josue. "Study on Air Interface Variants and their Harmonization for Beyond 5G Systems." Doctoral thesis, Universitat Politècnica de València, 2021. http://hdl.handle.net/10251/164442.

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[ES] La estandarización de la Quinta Generación de redes móviles o 5G, ha concluido este año 2020. No obstante, en el año 2014 cuando la ITU empezó el proceso de estandarización IMT-2020, una de las principales interrogantes era cuál sería la forma de onda sobre la cual se construiría la capa física de esta nueva generación de tecnologías. El 3GPP se comprometió a entregar una tecnología candidata al proceso IMT-2020, y es así como dentro de este proceso de deliberación se presentaron varias formas de onda candidatas, las cuales fueron evaluadas en varios aspectos hasta que en el año 2016 el 3

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Chen, Zihao. "Forecasting realized covariance matrices: New methods to improve financial decision making." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/235363/1/10393480%2BZihao%2BChen%2BThesis%281%29.pdf.

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This thesis consists of three studies that centre around forecasting realised volatility based on high-frequency financial data. Accurate volatility forecasts are used extensively in many financial applications. The methods used here draw on econometric models and machine learning techniques. The empirical studies are based on fifty stocks and two stock indices. The thesis has established new perspectives on forecasting the realised volatility asset returns to improve financial decision-making.

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Bester, Rachelle. "Sequencing and detection of a new strain of grapevine leafroll-associated virus 3 in South Africa." Thesis, Stellenbosch : Stellenbosch University, 2012. http://hdl.handle.net/10019.1/71743.

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Thesis (MSc)--Stellenbosch University, 2012.<br>ENGLISH ABSTRACT: Grapevine leafroll-associated virus 3 (GLRaV-3) is the type member of the genus Ampelovirus in the family Closteroviridae and is considered to be the main contributing agent of grapevine leafroll disease (GLD) worldwide. A metagenomic sequencing study of a grapevine leafroll-diseased vineyard led to the discovery of a new variant of GLRaV-3 in South Africa. This new variant was most related to a New Zealand isolate, NZ-1. In this study, we sequenced two isolates, GH11 and GH30, of the new variant group of GLRaV-3. These isolates

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Frerichmann, Sebastian Leo Max [Verfasser]. "Detection of new sequence variants for flowering and bolting time genes in species of the genus Beta / Sebastian Leo Max Frerichmann." Kiel : Universitätsbibliothek Kiel, 2013. http://d-nb.info/1036242811/34.

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Bergstrom, Alexander R. "SPECTROSCOPIC AND MECHANISTIC STUDIES OF METALLO-BETA-LACTAMASE INHIBITORS AND THE STRUCTURE-FUNCTION RELATIONSHIP OF NEW DELHI METALLO-BETA-LACTAMASE VARIANTS." Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1524154064246174.

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VanPelt, Jamie L. "NMR Studies of Klebsiella Pneumoniae Carbapenemase-2 Inhibition and Structural Characterization of New Delhi Metallo-β-Lactamase Variants and Ligand Complexes". Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1542725553898546.

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Belvederesi, Laura. "Mutazioni nei geni del MMR e sindrome HNPCC: analisi in vitro della patogenicità delle varianti missenso." Doctoral thesis, Università Politecnica delle Marche, 2007. http://hdl.handle.net/11566/242442.

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Fiorentino, V. "CHARACTERIZATION OF THE FUNCTIONAL ROLE OF NEW VARIANTS INVOLVED IN VARIEGATE PORPHYRIA AND HIPSC DERIVED HEPATOCYTE LIKE CELLS TO MODEL HEPATIC PORPHYRIAS." Doctoral thesis, Università degli Studi di Milano, 2018. http://hdl.handle.net/2434/544570.

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Porphyrias are a group of inherited metabolic disorders of heme biosynthesis. Each porphyria derives from an alteration in the heme biosynthetic pathway resulting in a specific accumulation of heme precursors. These rare diseases are characterized by an extended heterogeneity of mutations affecting the coding region of the genes directly or indirectly involved in the pathway. In this study, we assessed three new variants identified in the regulatory regions of the PPOX gene using human hepatocarcinoma (Hep3B) and erythroleukemia (K562) cell lines. We demonstrated a lower expression of the PPOX

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MELONI, CRISTIANA. "Identificazione di una variante missenso nel gene RBM10 in una famiglia sarda con disabilità intellettiva X-linked." Doctoral thesis, Università degli Studi di Cagliari, 2016. http://hdl.handle.net/11584/266631.

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X-linked intellectual disability (XLID) is a heterogeneous disorder, and mutations causing monogenic XLID have now been reported in over 100 genes. We report a five-generation Sardinian family in which seven affected male family members had intellectual disability and craniofacial dysmorphisms. Large-scale next generation exome resequencing of X chromosome genes detected a rare missense variant (c.995G>A, p.Arg332His) located within a highly conserved domain in the RBM10 gene at Xp11.23. Sanger sequencing confirmed the presence of the variant in affected males and in their mothers. The variant

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