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Journal articles on the topic 'New variant'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Farhud, D. D., P. Daneshmand, and P. Amirshani. "A new transferrin variant from Iran (Tf B-Iran): Review of 36 variant alleles." Anthropologischer Anzeiger 46, no. 4 (1988): 357–63. http://dx.doi.org/10.1127/anthranz/46/1988/357.

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Ruby Dhar, Hiya Aidasani, Om Saswat Sahoo, Arun Kumar, and Subhradip Karmakar. "JN.1: The new COVID-19 variant of concern?" Asian Journal of Medical Sciences 15, no. 2 (2024): 251–53. https://doi.org/10.71152/ajms.v15i2.3365.

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Emergence of new variants of COVID-19 is nothing new. Different variants evolved with additional mutations of the virus as part of the viral replication cycle have different infectious properties. JN.1 is the latest COVID-19 variant that seems to circulate the globe contributing to many infections and hospitalizations labeling it a variant of interest by the WHO. The scientific community has yet to understand its full lethal potential if any. In this mini-review, we summarized the facts known so far about this variant and its possible consequences if any for humanity.

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Ruby Dhar, Hiya Aidasani, Om Saswat Sahoo, Arun Kumar, and Subhradip Karmakar. "JN.1: The new COVID-19 variant of concern?" Asian Journal of Medical Sciences 15, no. 2 (2024): 251–53. http://dx.doi.org/10.3126/ajms.v15i2.61144.

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Emergence of new variants of COVID-19 is nothing new. Different variants evolved with additional mutations of the virus as part of the viral replication cycle have different infectious properties. JN.1 is the latest COVID-19 variant that seems to circulate the globe contributing to many infections and hospitalizations labeling it a variant of interest by the WHO. The scientific community has yet to understand its full lethal potential if any. In this mini-review, we summarized the facts known so far about this variant and its possible consequences if any for humanity.

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Anand, Aanchal, Samar Hossain, Akashdeep Sharma, and Ukshan Shah. "A new variant of COVID-19: But is it less deadly?" Indian Journal of Forensic and Community Medicine 9, no. 1 (2022): 44–46. http://dx.doi.org/10.18231/j.ijfcm.2022.010.

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WHO designated the variant B.1.1.529 as a variant of concern on 26 November 2021 and since then there have been many speculations regarding its origin and control measures. It is not yet clear if the omicron variant is more transmissible compared to other variants.

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Salaš, P. "New technologies and improvement of nursery stock quality." Horticultural Science 29, No. 4 (2012): 153–60. http://dx.doi.org/10.17221/4479-hortsci.

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This four years experimentation work was aimed at research on using various waste organic materials and especially timber bark in cultivation substrates as a substitute of peat. Sixty-four special isolated cultivation beds were established for this purpose, each of 4.8 m<sup>3</sup> volume, in which 11 variants of substrates consisting of different proportions of different components in several replications were tested. Standard substrates Horticultural substrate B and RKS I. were used as controls. Another variant was used as a control for growing tests of plants in containers. All

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Arka, Swarnakar. "BF.7: The new concern for dental practice?" Journal of Orofacial Rehabilitation 2, no. 3 (2022): i. https://doi.org/10.5281/zenodo.7492946.

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The year 2022 is about to end but a new variant of the Omicron COVID-19 is making everyone worried. This is known as the BF.7 variant. It is highly infectious having a reproduction rate of 10 to 18.6. Experts suggest that this variant will not affect the Indian population as the people here have hybrid immunity of both the vaccine doses and the exposure to other variants of the COVID-19 virus.

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Oliveira Roster, Kirstin I., Stephen M. Kissler, Enoma Omoregie, et al. "Surveillance strategies for the detection of new pathogen variants across epidemiological contexts." PLOS Computational Biology 20, no. 9 (2024): e1012416. http://dx.doi.org/10.1371/journal.pcbi.1012416.

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Surveillance systems that monitor pathogen genome sequences are critical for rapidly detecting the introduction and emergence of pathogen variants. To evaluate how interactions between surveillance capacity, variant properties, and the epidemiological context influence the timeliness of pathogen variant detection, we developed a geographically explicit stochastic compartmental model to simulate the transmission of a novel SARS-CoV-2 variant in New York City. We measured the impact of (1) testing and sequencing volume, (2) geographic targeting of testing, (3) the timing and location of variant

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Al Aawar, Majd, Srikar Mutnuri, Mansooreh Montazerin, and Ajitesh Srivastava. "Dynamics-Based Feature Augmentation of Graph Neural Networks for Variant Emergence Prediction." Proceedings of the AAAI Conference on Artificial Intelligence 39, no. 27 (2025): 27793–801. https://doi.org/10.1609/aaai.v39i27.34995.

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During the COVID-19 pandemic, a major driver of new surges has been the emergence of new variants. When a new variant emerges in one or more countries, other nations monitor its spread in preparation for its potential arrival. The impact of the new variant and the timings of epidemic peaks in a country highly depend on when the variant arrives. The current methods for predicting the spread of new variants rely on statistical modeling, however, these methods work only when the new variant has already arrived in the region of interest and has a significant prevalence. Can we predict when a varia

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Ullah, Amin, Khalid Mahmood Malik, Abdul Khader Jilani Saudagar, et al. "COVID-19 Genome Sequence Analysis for New Variant Prediction and Generation." Mathematics 10, no. 22 (2022): 4267. http://dx.doi.org/10.3390/math10224267.

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The new COVID-19 variants of concern are causing more infections and spreading much faster than their predecessors. Recent cases show that even vaccinated people are highly affected by these new variants. The proactive nucleotide sequence prediction of possible new variants of COVID-19 and developing better healthcare plans to address their spread require a unified framework for variant classification and early prediction. This paper attempts to answer the following research questions: can a convolutional neural network with self-attention by extracting discriminative features from nucleotide

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Li, Zongbin, Yudong Zhang, Claude Esling, Xiang Zhao, Yandong Wang, and Liang Zuo. "New approach to twin interfaces of modulated martensite." Journal of Applied Crystallography 43, no. 3 (2010): 617–22. http://dx.doi.org/10.1107/s002188981000868x.

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In Ni–Mn–Ga ferromagnetic shape memory alloys, the crystallographic nature of martensitic variant interfaces is one of the key factors governing the variant reorientation through field-induced interface motion and hence the shape memory performance. So far, the crystal structure studies of these materials – conducted by means of transmission electron microscopy – have suffered from uncertainties in determining the number of unit cells of modulated superstructure, and consequently improper interpretations of orientation correlations of martensitic variants. In this paper a new approach is prese

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Cheepsattayakorn, Attapon. "Omicron: A New Variant of SARS-CoV-2 (COVID-19)." Open Access Journal of Pulmonary & Respiratory Sciences 6, no. 1 (2021): 1. http://dx.doi.org/10.23880/oajprs-16000151.

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On November 24, 2021, the B.1.1.529 variant of SARSCoV-2 (COVID-19) was first reported from South Africa [1]. The first known confirmed B.1.1.529 infected specimen was collected on November 9, 2021 [1]. On November 25, 2021, daily case numbers in South Africa increased quickly with three distinct peaks in reported cases (the latest peak was predominantly the Delta variant) to more than 1,200 cases from 273 cases on November 16, 2021, more than 80% infected cases, including first case were in the northern province of Gauteng [2]. Currently, this variant is spreading, globally [2].

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Yang, Xiaofei, Qingyu Kong, Cuifen Zhao, Zhifeng Cai, and Minmin Wang. "New pathogenic variant of BMPR2 in pulmonary arterial hypertension." Cardiology in the Young 29, no. 4 (2019): 462–66. http://dx.doi.org/10.1017/s1047951119000015.

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AbstractObjectives:The aim of this study was to evaluate the variant frequency of pulmonary arterial hypertension-related genes and provide theoretical basis for genetic screening of patients with pulmonary arterial hypertension further.Methods:Ten genes associated with pulmonary arterial hypertension were sequenced in 7 cases of idiopathic pulmonary arterial hypertension and 34 cases of congenital heart disease (CHD) associated with pulmonary arterial hypertension by next-generation high-throughput sequencing. Function prediction and gene variant amino acid conservation were carried out by bi

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Brandl, Andrea Lindmayr. "Early Music Prints and New Technology: Variants and Variant Editions." Fontes Artis Musicae 64, no. 3 (2017): 244–59. http://dx.doi.org/10.1353/fam.2017.0027.

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14

Piantham, Chayada, and Kimihito Ito. "Predicting the Trajectory of Replacements of SARS-CoV-2 Variants Using Relative Reproduction Numbers." Viruses 14, no. 11 (2022): 2556. http://dx.doi.org/10.3390/v14112556.

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New variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with high effective reproduction numbers are continuously being selected by natural selection. To establish effective control measures for new variants, it is crucial to know their transmissibility and replacement trajectory in advance. In this paper, we conduct retrospective prediction tests for the variant replacement from Alpha to Delta in England, using the relative reproduction numbers of Delta with respect to Alpha estimated from partial observations. We found that once Delta’s relative frequency reached 0.1

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García Rabaneda, Carmen, María Luz Bellido Díaz, Ana Isabel Morales García, et al. "Clinical Utility of Genetic Testing with Geographical Locations in ADPKD: Describing New Variants." Journal of Clinical Medicine 13, no. 6 (2024): 1751. http://dx.doi.org/10.3390/jcm13061751.

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Background: Our study aims to comment on all ADPKD variants identified in our health area and explain how they are distributed geographically, to identify new variants, and relate the more frequent variants with their renal phenotype in terms of kidney survival. Materials and Methods: We identified patients suffering from ADPKD in a specialized consultation unit; genealogical trees were constructed from the proband. According to the ultrasound-defined modified Ravine–Pei criteria, relatives classified as at risk were offered participation in the genetic study. Socio-demographic, clinical, and

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16

Le Page, Michael. "New variant gains ground." New Scientist 252, no. 3362 (2021): 8. http://dx.doi.org/10.1016/s0262-4079(21)02091-1.

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PRIMROSE, D. A. "MUCOPOLYSACCHARIDOSIS: A NEW VARIANT?" Journal of Intellectual Disability Research 16, no. 3 (2008): 167–72. http://dx.doi.org/10.1111/j.1365-2788.1972.tb01173.x.

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18

Lang, C., J. Heckmann, and B. Neundörfer. "New variant or iatrogenic?" Acta Neuropathologica 102, no. 6 (2001): 645–46. http://dx.doi.org/10.1007/s004010000338.

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19

Han, Shengtong. "Bayesian Rare Variant Analysis Identifies Novel Schizophrenia Putative Risk Genes." Journal of Personalized Medicine 14, no. 8 (2024): 822. http://dx.doi.org/10.3390/jpm14080822.

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The genetics of schizophrenia is so complex that it involves both common variants and rare variants. Rare variant association studies of schizophrenia are challenging because statistical methods for rare variant analysis are under-powered due to the rarity of rare variants. The recent Schizophrenia Exome meta-analysis (SCHEMA) consortium, the largest consortium in this field to date, has successfully identified 10 schizophrenia risk genes from ultra-rare variants by burden test, while more risk genes remain to be discovered by more powerful rare variant association test methods. In this study,

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Kapás, Judit. "NEW VARIANT OF THE FIRM: A MARKET‐LIKE FORM." Journal of Business Economics and Management 5, no. 4 (2004): 217–28. http://dx.doi.org/10.3846/16111699.2004.9636085.

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The paper is concerned with the issue of variants within a firm, the causes of their emergence and coexistence. A particular attention is paid to the New Economy's variant called market‐like form. It is contrasted with the M‐form firm that was dominated over the last century. Significant shift in physical technology is thought to be a major force driving the evolution process of a firm which is characterized by the emergence of new variants. The paper also analyzes how the character of the production technology determines which variant of the firm is the best suitable to a particular technolog

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21

David, Hugo, Jlenia Monfregola, Isaura Ribeiro, et al. "Investigating p.Ala1035Val in NPC1: New Cellular Models for Niemann–Pick Type C Disease." International Journal of Molecular Sciences 25, no. 22 (2024): 12186. http://dx.doi.org/10.3390/ijms252212186.

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Niemann–Pick type C (NPC) is a lysosomal storage disorder (LSD) caused by pathogenic variants in either the NPC1 or NPC2 genes, which encode proteins involved in the lysosomal export of unesterified cholesterol. In patients of Western European descent, the p.Ile1061Thr variant in NPC1 is especially prevalent. However, mounting evidence has positioned p.Ala1035Val as the most common variant in Portugal and the second most prevalent variant worldwide. By analyzing 10 Portuguese NPC patients homozygous for p.Ala1035Val, we found an SNP in cis on position 858 (p.Ile858Val), which we hypothesize co

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Xu, Anping, Weidong Chen, Weijie Xie, Yajun Wang, and Ling Ji. "Hemoglobin variants in southern China: results obtained during the measurement of glycated hemoglobin in a large population." Clinical Chemistry and Laboratory Medicine (CCLM) 59, no. 1 (2021): 227–32. http://dx.doi.org/10.1515/cclm-2020-0767.

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AbstractObjectivesHemoglobin (Hb) variant is one of the most common monogenic inherited disorders. We aimed to explore the prevalence and hematological and molecular characteristics of Hb variants in southern China.MethodsWe collected blood samples from all patients with suspected variants found during HbA1c measurement via a cation-exchange high-performance liquid chromatography system (Bio-Rad Variant II Turbo 2.0) or a capillary electrophoresis method (Sebia Capillarys). Hematological analysis, Sanger sequencing, and gap-PCR were performed for these samples.ResultsAmong the 311,024 patients

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23

W, Gul. "Is Omicron, the New Variant, Deadlier than the Previous Strains?" Bioequivalence & Bioavailability International Journal 5, no. 2 (2021): 1–2. http://dx.doi.org/10.23880/beba-16000157.

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Golubeva, Volha A., Thales C. Nepomuceno, and Alvaro N. A. Monteiro. "Germline Missense Variants in BRCA1: New Trends and Challenges for Clinical Annotation." Cancers 11, no. 4 (2019): 522. http://dx.doi.org/10.3390/cancers11040522.

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Genetic testing allows for the identification of germline DNA variations, which are associated with a significant increase in the risk of developing breast cancer (BC) and ovarian cancer (OC). Detection of a BRCA1 or BRCA2 pathogenic variant triggers several clinical management actions, which may include increased surveillance and prophylactic surgery for healthy carriers or treatment with the PARP inhibitor therapy for carriers diagnosed with cancer. Thus, standardized validated criteria for the annotation of BRCA1 and BRCA2 variants according to their pathogenicity are necessary to support c

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Usmani, Arif, and Syeda Qasim. "Clear Cell Acanthoma: A Review of Clinical and Histologic Variants." Dermatopathology 7, no. 2 (2020): 26–37. http://dx.doi.org/10.3390/dermatopathology7020005.

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Degos and Civatte first described clear cell acanthoma (CCA) in 1962 and later in a review article found that, in most instances, the lesion was a solitary red-brown dome-shaped papule that involved the distal lower extremity. The first morphologic variant of CCA was reported as a “giant form of the acanthoma of Degos” which measured 45 × 40 mm, about twice the size of the largest CCA documented earlier. Since then, many variants of CCA have been described, including polypoid, pigmented and atypical. Herein, we describe a new variant of CCA and add another example of the polypoid variant to th

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MOLINEAUX, L., H. H. DIEBNER, M. EICHNER, W. E. COLLINS, G. M. JEFFERY, and K. DIETZ. "Plasmodium falciparum parasitaemia described by a new mathematical model." Parasitology 122, no. 4 (2001): 379–91. http://dx.doi.org/10.1017/s0031182001007533.

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A new mathematical model of Plasmodium falciparum asexual parasitaemia is formulated and fitted to 35 malaria therapy cases making a spontaneous recovery after primary inoculation. Observed and simulated case-histories are compared with respect to 9 descriptive statistics. The simulated courses of parasitaemia are more realistic than any previously published. The model uses a discrete time-step of 2 days. Its realistic behaviour was achieved by the following combination of features (i) intra-clonal antigenic variation, (ii) large variations of the variants' baseline growth rate, depending on b

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Lee, Danusorn, and Unitsa Sangket. "VOE: automated analysis of variant epitopes of SARS-CoV-2 for the development of diagnostic tests or vaccines for COVID-19." PeerJ 12 (June 19, 2024): e17504. http://dx.doi.org/10.7717/peerj.17504.

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Background The development of serodiagnostic tests and vaccines for COVID-19 depends on the identification of epitopes from the SARS-CoV-2 genome. An epitope is the specific part of an antigen that is recognized by the immune system and can elicit an immune response. However, when the genetic variants contained in epitopes are used to develop rapid antigen tests (Ag-RDTs) and DNA or RNA vaccines, test sensitivity and vaccine efficacy can be low. Methods Here, we developed a “variant on epitope (VOE)” software, a new Python script for identifying variants located on an epitope. Variant analysis

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Wei, Fengying, Ruiyang Zhou, Zhen Jin, et al. "Studying the impacts of variant evolution for a generalized age-group transmission model." PLOS ONE 19, no. 7 (2024): e0306554. http://dx.doi.org/10.1371/journal.pone.0306554.

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The differences of SARS-CoV-2 variants brought the changes of transmission characteristics and clinical manifestations during the prevalence of COVID-19. In order to explore the evolution mechanisms of SARS-CoV-2 variants and the impacts of variant evolution, the classic SIR (Susceptible-Infected-Recovered) compartment model was modified to a generalized SVEIR (Susceptible-Vaccinated-Exposed-Infected-Recovered) compartment model with age-group and varying variants in this study. By using of the SVEIR model and least squares method, the optimal fittings against the surveillance data from Fujian

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Jessen, Randi, Line Nielsen, Nicolai Balle Larsen, et al. "A RT-qPCR system using a degenerate probe for specific identification and differentiation of SARS-CoV-2 Omicron (B.1.1.529) variants of concern." PLOS ONE 17, no. 10 (2022): e0274889. http://dx.doi.org/10.1371/journal.pone.0274889.

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Fast surveillance strategies are needed to control the spread of new emerging SARS-CoV-2 variants and gain time for evaluation of their pathogenic potential. This was essential for the Omicron variant (B.1.1.529) that replaced the Delta variant (B.1.617.2) and is currently the dominant SARS-CoV-2 variant circulating worldwide. RT-qPCR strategies complement whole genome sequencing, especially in resource lean countries, but mutations in the targeting primer and probe sequences of new emerging variants can lead to a failure of the existing RT-qPCRs. Here, we introduced an RT-qPCR platform for de

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Walker, Emma C., Rashmi Ramani, Sarah Javati, et al. "A novel variant in ubiquinone biosynthesis highly prevalent in Papua New Guinea children increases mortality following bacterial pneumonia." Journal of Immunology 204, no. 1_Supplement (2020): 231.5. http://dx.doi.org/10.4049/jimmunol.204.supp.231.5.

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Abstract To identify immune variants predisposing to severe pneumonia, we performed whole exome sequencing in a pediatric population highly susceptible to acute lower respiratory infections, identifying a candidate novel variant in the ubiquinone (CoQ10) biosynthetic pathway. To evaluate the effect of this variant on immune function during bacterial pneumonia, we generated a mouse line using CRISPR-Cas9 that expresses the homologous aspartate to tyrosine variant in the enzyme COQ6. Intra-tracheal S. pneumoniae infection leads to increased bacteremia and mortality in mice homozygous for the var

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Nugraha, Bharmatisna Anggaharsya. "Review of Genetic Variants of Butyrylcholinesterase and Their Potential Impact on Human Health." Open Access Indonesian Journal of Medical Reviews 1, no. 6 (2021): 135–40. http://dx.doi.org/10.37275/oaijmr.v1i6.56.

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Butyrylcholinesterase (BChE) is an enzyme found in plasma and many other parts of the body. It is enzyme that hydrolyses drugs containing ester bonds such as drugs acting at the neuromuscular junction (succinylcholine) and local anaesthetics (procaine). Examination of the gene for mutations or polymorphisms causing the observed biochemical phenotypes has isolated those responsible for all the most widely known variants. The molecular bases of several genetic variants of BChE have been reported, such as the Atypical variant, fluoride-resistant variant, silent variant, K variant, J variant and C

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Nugraha, Bharmatisna Anggaharsya. "Review of Genetic Variants of Butyrylcholinesterase and Their Potential Impact on Human Health." Natural Sciences Engineering and Technology Journal 1, no. 1 (2021): 23–28. http://dx.doi.org/10.37275/nasetjournal.v1i1.5.

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Butyrylcholinesterase (BChE) is an enzyme found in plasma and many other parts of the body. It is enzyme that hydrolyses drugs containing ester bonds such as drugs acting at the neuromuscular junction (succinylcholine) and local anaesthetics (procaine). Examination of the gene for mutations or polymorphisms causing the observed biochemical phenotypes has isolated those responsible for all the most widely known variants. The molecular bases of several genetic variants of BChE have been reported, such as the Atypical variant, fluoride-resistant variant, silent variant, K variant, J variant and C

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Nugraha, Bharmatisna Anggaharsya. "Review of Genetic Variants of Butyrylcholinesterase and Their Potential Impact on Human Health." Open Access Indonesian Journal of Medical Reviews 1, no. 6 (2021): 135–45. http://dx.doi.org/10.37275/oaijmr.v1i6.575.

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Butyrylcholinesterase (BChE) is an enzyme found in plasma and many other parts of the body. It is enzyme that hydrolyses drugs containing ester bonds such as drugs acting at the neuromuscular junction (succinylcholine) and local anaesthetics (procaine). Examination of the gene for mutations or polymorphisms causing the observed biochemical phenotypes has isolated those responsible for all the most widely known variants. The molecular bases of several genetic variants of BChE have been reported, such as the Atypical variant, fluoride-resistant variant, silent variant, K variant, J variant and C

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Kobayashi, Yusuke, Takeshi Arashiro, Miyako Otsuka, et al. "Replacement of SARS-CoV-2 strains with variants carrying N501Y and L452R mutations in Japan: an epidemiological surveillance assessment." Western Pacific Surveillance and Response Journal 13, no. 3 (2022): 41–50. http://dx.doi.org/10.5365/wpsar.2022.13.3.943.

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Objective: Monitoring the prevalence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants is important due to concerns regarding infectivity, transmissibility, immune evasion and disease severity. We evaluated the temporal and regional replacement of previous SARS-CoV-2 variants by the emergent strains, Alpha and Delta. Methods: We obtained the results of polymerase chain reaction screening tests for variants conducted in multiple commercial laboratories. Assuming that all previous strains would be replaced by one variant, the new variant detection rate was estimated by fit

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Lambisia, Arnold W., Joyce U. Nyiro, John M. Morobe, et al. "Detection of a SARS-CoV-2 Beta-like variant in coastal Kenya after more than a year of disappearance." Wellcome Open Research 8 (January 20, 2023): 34. http://dx.doi.org/10.12688/wellcomeopenres.18700.1.

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Continuous genomic surveillance is necessary and important to inform emergence of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and resurgence of previous circulating variants. In this study, we provide genomic characterisation of a Beta variant sequence identified through out genomic surveillance platform more than a year since the last reported case of Beta. This variant contained additional mutations associated with immune escape that have been observed in other newer variants such as Delta and Omicron implying ongoing convergent evolution of this variant in the

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Dhar, Ruby, Joyeeta Talukdar, Arnab Nayek, Swati Ajmeriya, Arun Kumar, and Subhradip Karmakar. "Unveiling the omicron B.1.1. 529: The variant of concern that is rattling the globe." Asian Journal of Medical Sciences 13, no. 1 (2022): 166–68. http://dx.doi.org/10.3126/ajms.v13i1.41117.

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Most viruses–including SARS-CoV-2, seem to have evolved over time. The lack of stringent proofreading mechanisms makes viral DNA/RNA replication error-prone. When a virus replicates, it sometimes changes a little bit, which is called mutations. Any virus with one or more new mutations can be referred to as a “variant” of the original virus. The last 2 years have witnessed the emergence of a large number of variants. Since the pandemic’s beginning, the SARS-CoV-2 coronavirus has mutated extensively, resulting in the emergence of different variants of the virus. One of these is the delta variant

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Ruby Dhar, Joyeeta Talukdar, Arnab Nayek, Swati Ajmeriya, Arun Kumar, and Subhradip Karmakar. "Unveiling the omicron B.1.1. 529: The variant of concern that is rattling the globe." Asian Journal of Medical Sciences 13, no. 1 (2022): 166–68. https://doi.org/10.71152/ajms.v13i1.3840.

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Most viruses–including SARS-CoV-2, seem to have evolved over time. The lack of stringent proofreading mechanisms makes viral DNA/RNA replication error-prone. When a virus replicates, it sometimes changes a little bit, which is called mutations. Any virus with one or more new mutations can be referred to as a “variant” of the original virus. The last 2 years have witnessed the emergence of a large number of variants. Since the pandemic’s beginning, the SARS-CoV-2 coronavirus has mutated extensively, resulting in the emergence of different variants of the virus. One of these is the delta variant

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Strasser, Zachary H., Noah Greifer, Aboozar Hadavand, Shawn N. Murphy, and Hossein Estiri. "Estimates of SARS-CoV-2 Omicron BA.2 Subvariant Severity in New England." JAMA Network Open 5, no. 10 (2022): e2238354. http://dx.doi.org/10.1001/jamanetworkopen.2022.38354.

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ImportanceThe SARS-CoV-2 Omicron subvariant, BA.2, may be less severe than previous variants; however, confounding factors make interpreting the intrinsic severity challenging.ObjectiveTo compare the adjusted risks of mortality, hospitalization, intensive care unit admission, and invasive ventilation between the BA.2 subvariant and the Omicron and Delta variants, after accounting for multiple confounders.Design, Setting, and ParticipantsThis was a retrospective cohort study that applied an entropy balancing approach. Patients in a multicenter inpatient and outpatient system in New England with

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Stokowy, Tomasz, Danuta Gawel, and Bartosz Wojtas. "Differences in miRNA and mRNA Profile of Papillary Thyroid Cancer Variants." International Journal of Endocrinology 2016 (2016): 1–10. http://dx.doi.org/10.1155/2016/1427042.

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Papillary thyroid cancer (PTC) can be divided into classical variant of PTC (cPTC), follicular variant of PTC (fvPTC), and tall cell variant (tcPTC). These variants differ in their histopathology and cytology; however, their molecular background is not clearly understood. Our results shed some new light on papillary thyroid cancer biology as new direct miRNA-gene regulations are discovered. The Cancer Genome Atlas (TCGA) 466 thyroid cancer samples were studied in parallel datasets to discover potential miRNA-mRNA regulations. Additionally, miRNAs and genes differentiating PTC variants (cPTC, f

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Garcia Brás, Pedro, Isabel Cardoso, José Viegas, Diana Antunes, and Sílvia Aguiar Rosa. "Sudden Cardiac Death in Biventricular Arrhythmogenic Cardiomyopathy: A New Undescribed Variant of the MYH6 Gene." Cardiogenetics 13, no. 4 (2023): 145–53. http://dx.doi.org/10.3390/cardiogenetics13040014.

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Arrhythmogenic cardiomyopathy (ACM) may present with sudden cardiac arrest (SCA), and demonstration of a pathogenic variant in ACM-related genes is crucial for its definitive diagnosis. A 42-year-old female patient with family history of sudden cardiac death (SCD) was referred to the cardiomyopathy clinic after two episodes of aborted SCA. In the second episode, the patient was transported under cardiopulmonary resuscitation (downtime of 57 min) until extracorporeal membrane oxygenation was implanted. A thorough diagnostic work-up led to a diagnosis of biventricular ACM. Genetic testing reveal

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Mohseni Afshar, Zeinab, Ali Tavakoli Pirzaman, Bardia Karim, et al. "SARS-CoV-2 Omicron (B.1.1.529) Variant: A Challenge with COVID-19." Diagnostics 13, no. 3 (2023): 559. http://dx.doi.org/10.3390/diagnostics13030559.

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Since the beginning of the coronavirus disease 2019 (COVID-19) pandemic, there have been multiple peaks of the SARS-CoV-2 (severe acute respiratory syndrome coronavirus virus 2) infection, mainly due to the emergence of new variants, each with a new set of mutations in the viral genome, which have led to changes in the pathogenicity, transmissibility, and morbidity. The Omicron variant is the most recent variant of concern (VOC) to emerge and was recognized by the World Health Organization (WHO) on 26 November 2021. The Omicron lineage is phylogenetically distinct from earlier variants, includ

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M, Kulshreshtha. "Omicron; New COVID-19 Strain." Bioequivalence & Bioavailability International Journal 7, no. 2 (2023): 1–3. http://dx.doi.org/10.23880/beba-16000200.

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After the few years of COVID -19, Omicron has reported as a new variant found in the Botswana. Some studies have reported that it is much milder then COVID-19. Symptoms include cough, fatigue, loss of smell, runny nose etc. It is not clear that Omicron can transfer from one person to another. Treatment is not clear. This short view is my best collection of published scientific data on Omicron till now. It also includes the origin, epidemiological data, and treatment etc. of new variant.

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Vechorko, V. I., O. V. Averkov, and A. A. Zimin. "New SARS-CoV-2 Omicron variant — clinical picture, treatment, prevention (literature review)." Cardiovascular Therapy and Prevention 21, no. 6 (2022): 3228. http://dx.doi.org/10.15829/1728-8800-2022-3228.

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Despite the decrease in the incidence rate, today the problem of a coronavirus disease 2019 (COVID-19) remains relevant on a global scale. Among the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2) variants, the Omicron is currently dominant. The differentiating properties of the Omicron variant are a shorter incubation period (1-5 days), high contagiousness, and a relatively mild course of the disease, which is associated with the highest number of genome mutations among all SARS-CoV-2 variants. The new variant is characterized by upper respiratory tract symptoms: rhinorrhea, seve

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Ramani, KrishnaKumar, JameelRizwana Hussaindeen, Mithra Anand, Viswanathan Sivaraman, and PeterM Allen. "Variant myopia: A new presentation?" Indian Journal of Ophthalmology 66, no. 6 (2018): 799. http://dx.doi.org/10.4103/ijo.ijo_1115_17.

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Nicholas Russo, S., Ekta G. Shah, William C. Copeland, and Mary Kay Koenig. "A new pathogenic POLG variant." Molecular Genetics and Metabolism Reports 32 (September 2022): 100890. http://dx.doi.org/10.1016/j.ymgmr.2022.100890.

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Wilson, Clare. "Testing for the new variant." New Scientist 253, no. 3369 (2022): 9. http://dx.doi.org/10.1016/s0262-4079(22)00031-8.

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Jeon, Beom Seok. "New Variant Creutzfeldt-Jakob Disease." Journal of the Korean Medical Association 44, no. 5 (2001): 483. http://dx.doi.org/10.5124/jkma.2001.44.5.483.

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Harne, Swapnil, Manish Pathak, and Kamal Nayan Rattan. "New Variant of Esophageal Atresia." Journal of Neonatal Surgery 6, no. 1 (2016): 9. http://dx.doi.org/10.21699/jns.v6i1.464.

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Esophageal atresia with tracheoesophageal fistula (EA/TEF) associated with distal congenital esophageal stenosis (CES) is a well-known entity. We encountered three patients of EA/TEF associated with long and unusual CES.

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Swami, Meera. "A new PTEN translational variant." Nature Medicine 19, no. 7 (2013): 827. http://dx.doi.org/10.1038/nm.3277.

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Elston, J. S. "A new variant of blepharospasm." Journal of Neurology, Neurosurgery & Psychiatry 55, no. 5 (1992): 369–71. http://dx.doi.org/10.1136/jnnp.55.5.369.

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