To see the other types of publications on this topic, follow the link: NGER Act.
Journal articles on the topic 'NGER Act'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 20 journal articles for your research on the topic 'NGER Act.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Mia, Parvez, Tarek Rana, and Lutfa Tilat Ferdous. "Government Reform, Regulatory Change and Carbon Disclosure: Evidence from Australia." Sustainability 13, no. 23 (November 30, 2021): 13282. http://dx.doi.org/10.3390/su132313282.
Full textAbstract:
This paper examines the effect of two Australian environmental regulatory changes, specifically the Clean Energy Act (CEA) 2011 and the National Greenhouse and Energy Reporting (NGER) Act 2007 with reference to voluntary corporate carbon disclosure practices. In doing so, it describes the brief history of this carbon-related regulatory change, its scope, enforcement criteria and corporations’ disclosures. This is a longitudinal analysis of 219 annual reports of 73 listed corporations in Australia which were subjected to carbon tax and report carbon emissions as per the CEA 2011 and NGER Act 2007 accordingly. Any corporation or facility that emitted scope 1 emissions of 25,000 tonnes of carbon dioxide equivalent (CO2-e) or more were liable for a carbon tax in accordance with CEA 2011. Drawing on stakeholder theory and legitimacy theory, this study uses content analysis to examine corporate carbon disclosure. The findings suggest there is a considerable increase in the number of carbon-related disclosures following these regulations being enacted as law. In addition, carbon-specific communication has become much more prevalent and accounts for a larger proportion of the sampled organisations’ reported environmental information. The results of this study enrich the validity of the hypothesis that organisations would seek to legitimise their operations to stakeholders by increasing their environment-related declarations. The evidence presented in the analysis confirms the assertion that government environmental legislation/regulation has a positive impact on corporate behaviour and accountability. These findings have significant consequences for the government, decision-makers and the accounting profession, indicating that regulatory guidance enhances both mandatory and voluntary disclosure. It also offers key insights into the possible impacts of the carbon regulatory change for future research to consider.
2
Borghei, Zahra, Philomena Leung, and James Guthrie. "The nature of voluntary greenhouse gas disclosure – an explanation of the changing rationale." Meditari Accountancy Research 24, no. 1 (April 11, 2016): 111–33. http://dx.doi.org/10.1108/medar-02-2015-0008.
Full textAbstract:
Purpose This paper aims to explore the nature of voluntary greenhouse gas (GHG) disclosure by non-GHG-registered companies among industry sectors over a period after the introduction of the National Greenhouse and Energy Reporting (NGER) Act 2007 and before the introduction of the Australian ETS. Design/methodology/approach A GHG disclosure index is used to evaluate the levels of GHG disclosure in 2009 and 2011 annual reports. Findings This paper highlights that non-GHG-registered companies seem to improve their disclosure by incorporating more “behavioural management” actions rather than “symbolic” actions. The changing rationale of GHG disclosure is towards more serious GHG reduction strategies. Consistent with voluntary disclosure and signalling theories, companies having good news to tell disclose their superior GHG information to promote their superior environmental performance. Research limitations/implications The findings should be useful for stakeholders who are interested in GHG disclosure strategies. Also, the content analysis of the annual reports provides some clarity in respect of the most common aspects of GHG disclosure by non-GHG-registered companies which is helpful in the evaluation of correspondence between carbon disclosure strategies and the objectives of carbon abatement. Originality/value Previous studies mostly investigate the differences in the type of GHG disclosure among companies subject to mandatory GHG regulations. However, this paper is the first study to examine the changing rationale in the nature of GHG disclosure of non-GHG-registered companies. While much of the prior research uses GHG-registered companies as the sample, no empirical study to date has considered non-GHG-registered companies that encompass 96 per cent of ASX listed companies.
3
Yunus, Somaiya, Evangeline O. Elijido-Ten, and Subhash Abhayawansa. "Impact of stakeholder pressure on the adoption of carbon management strategies." Sustainability Accounting, Management and Policy Journal 11, no. 7 (February 10, 2020): 1189–212. http://dx.doi.org/10.1108/sampj-04-2019-0135.
Full textAbstract:
Purpose This paper aims to examine whether the perceived pressures from stakeholders with high potential to cooperate and/or threaten the firm’s survival affect the decision to adopt carbon management strategies (CMSs). Design/methodology/approach A logistic panel regression model is estimated using longitudinal data from Australia’s Top-200 listed firms over seven years from 2009 to 2015. The authors test the firm’s propensity to adopt CMSs conditioned on the influence of four groups of stakeholders: the regulators, institutional investors, media and creditors. Data on CMSs adopted by firms are sourced from Thomson Reuters ASSET4 database, the Carbon Disclosure Project survey, annual reports, company websites and sustainability reports. Findings The authors show that stakeholder pressures are associated not only with the adoption or non-adoption of CMSs but also with the type of CMSs adopted. Three types of CMSs are identified, namely, compensation, reduction and innovation strategies. The findings reveal that CMS adoption and the firms’ propensity to adopt compensation and reduction strategies are significantly related to perceived pressures from the regulators, media and creditors. While pressure from the regulators is also associated with the firms’ propensity to adopt innovation strategies, a more advanced type of CMSs, the potential pressure from the media and creditors are not significantly related. Practical implications The findings imply that a firm’s adoption of CMSs is not merely about managing stakeholders in the regulatory sphere but also about taking into account the perceived pressures from non-regulatory stakeholders and the context-dependent nature of their influences. The authors show that by influencing the voluntary disclosure of carbon emissions, the government continues to be effective in encouraging firms to take action on climate change despite the abolition of the carbon tax in Australia. Social implications This study highlights that, apart from a heavy-handed approach, regulators can adopt softer forms of regulation such as the National Greenhouse and Energy Reporting (NGER) Act and a less invasive, stakeholder-driven approach to encourage firms to adopt CMSs and thereby work towards climate change mitigation. Originality/value This study extends the literature by showing that perceived pressure from some stakeholders found to be influential in relation to some corporate decisions (such as environmental strategy adoption and climate-change-related disclosure) may not necessarily be influential in relation to CMS adoption.
4
Goodyer, Cynthia G., Sorana Marcovitz, Jules Hardy, Yves Lefebvre, Harvey J. Guyda, and Barry I. Posner. "Effect of insulin-like growth factors on human foetal, adult normal and tumour pituitary function in tissue culture." Acta Endocrinologica 112, no. 1 (May 1986): 49–57. http://dx.doi.org/10.1530/acta.0.1120049.
Full textAbstract:
Abstract. To determine the direct effects of insulin-like growth factors (IGFs) on hormone release by the human pituitary gland, human foetal, adult normal and tumour pituitary tissues were maintained in culture for 2 to 4 weeks and tested with acute (3 h) exposures to different preparations of IGF peptides. Adult normal pituitaries and adenomas were tested with a semipurified preparation of IGFs, free of immunoreactive insulin, containing IGF-I and IGF-II in a ratio of approximately 1:4. Human foetal pituitaries were tested with the semipurified IGFs as well as more purified preparations of IGF-I and IGF-II. Culture media were assayed for hGH, hPrl, hACTH and hLH using specific radioimmunoassays. Both foetal (n = 16 (No. of pituitaries), 33 (No. of observations)) and normal adult (n = 3, 16) human pituitaries cultures responded to the semipurified IGFs (2–25 ngEq/ml for foetal and 2–4 ngEq/ml for adult pituitaries) with a significant decrease in hGH release compared to basal (P < 0.01) whereas the GH-secreting pituitary tumours showed no effect when tested with from 2 to 25 ngEq/ml (n = 8, 129, ns). The effect of IGFs on human foetal somatotrope activity was dose-related for both the semipurified IGFs (2–25 ngEq/ml, n = 16, 33) and IGF-I or IGF-II (10–100 ng/ml; n = 3, 18). hPrl release was inhibited in the normal adult (n = 2, 12; P < 0.01) but not in the foetal (n = 2, 9; ns) pituitary cultures by 2–4 ngEq/ml of the semipurified IGFs, while the Prl-secreting pituitary tumour cultures showed variable responses to 3–4 ngEq/ml of the same IGFs preparation (a) suppression: n = 1, 14, P < 0.001; b) no effect: n = 3, 28, ns). hGH release was inhibited in one of the two mixed (GH- and Prl-secreting) tumours examined (n = 1, 10, P < 0.02) and unaffected in the other (n = 1, 14, ns), while hPrl release remained unchanged in both. The IGFs did not alter release of hLH or hACTH by either foetal or normal adult pituitaries. Conclusions: A semipurified preparation of IGFs directly inhibited hGH release by human foetal pituitaries and hGH and hPrl release by normal adult pituitaries but had no effect on hLH or hACTH secretion. Human foetal somatotropes responded to IGF-I and IGF-II in a similar dose-dependent manner suggesting that, like in the rat, both IGF peptides can have an inhibitory influence on GH secretion. GH- and/or Prl-secreting pituitary adenomas showed a predominant lack of responsiveness to the semipurified IGFs, suggesting that the sensitivity of somatotropes and lactotropes to an IGF inhibitory influence is often abnormal in the tumour state.
5
morano, nicholas, Sarah Garret, and Steven Almo. "Structural and Functional Investigations Into B7-1:NGFR." Journal of Immunology 202, no. 1_Supplement (May 1, 2019): 229.7. http://dx.doi.org/10.4049/jimmunol.202.supp.229.7.
Full textAbstract:
Abstract Although Nerve Growth Factor Receptor (NGFR, TNFSFR16) is traditionally thought of as a receptor that regulates the growth of neurons, it is also widely expressed throughout the immune system in response to inflammation where its function is poorly characterized. In addition to binding the four neurotrophins (NGF, BDNF, NT3, NT4), the Almo lab and others have recently discovered that NGFR can also act as a receptor for B7-1 (CD80). B7-1 is a major costimulatory molecule expressed on antigen presenting cells (APCs) such as dendritic cells, macrophages, and microglia in response to inflammation. B7-1 can bind to CD28 on naïve T-cells, which induces T-cell activation. It can then bind CTLA4 (upregulated on T cells after CD28 activation), which reduces activation. B7-1 also interacts with PD-L1. The structure and function of the B7-1-NGFR interaction is currently unknown. We have recently conducted epitope mapping experiments that suggest the NGFR binds to B7-1 on the same interface that CD28 and CTLA4 bind to B7-1. This interface appears to be independent of the PD-L1-B7-1 binding interface. NGFR epitope mapping data suggests that B7-1 binds to NGFR near the binding site for NGF, and similarly to other TNFRSF receptor-ligand interactions. Furthermore, our data shows that NGFR and CTLA4 can compete for binding to B7-1. In addition, we are investigating the role the B7-1:NGFR binding plays in neurons.
6
Quirici, Nadia, Davide Soligo, Chiara Borsotti, Cinzia Scavullo, Stefano Zangrossi, and Giorgio Lambertenghi-Deliliers. "Phenotypic and Molecular Characterization of Bone Marrow L-NGFR + Mesenchymal Stem Cells." Blood 104, no. 11 (November 16, 2004): 2333. http://dx.doi.org/10.1182/blood.v104.11.2333.2333.
Full textAbstract:
Abstract In a previous report we demonstrated that the immunomagnetic sorting of bone marrow (BM) cells labeled with low-affinity nerve growth factor receptor (L-NGFR) antibodies allows the selection of phenotypically and functionally homogeneous cells that are capable of expansion, self-renewal and differentiation into multiple mesenchymal cells lineages. Furthermore, we reported the presence of a subpopulation of L-NGFR+ cells coexpressing CD133 and CD34, markers associated with a primitive hematopoietic stem cell phenotype. In the present study we expanded on the phenotypic characterization of these cells and investigated their potential for multilineage differentiation. BM L-NGFR+ cells were analyzed by flow cytometry immediately after immunoseparation and the expression of a variety of stem cell markers was studied. In 12 subsequent experiments L-NGFR+ cells expressed CD45low (97.5% ±3), CD34 (19.9%±13), CD133 (10.4%±6), CD105 (46.8%±36%), P1H12 (50.5%±18), KDR (34%±18) and SSEA-3 (0.47%±0.41). In addition L-NGFR+ expressed high levels of the SCF ligand CD117 (40%±16%). As we previously demonstrated, L-NGFR antibodies identify a subpopulation of cells with a high proliferative capacity and potential for multilineage differentiation along the mesenchymal lineage. We now show, in accordance to these phenotypic data, that the L-NGFR+ cells in the presence of SCF (100 ng/ml) doubled the number of CFU-F and expanded both adipocytic and osteoblastic differentiation in comparison to mesenchymal cultures without growth factors or supplemented with Flt-3L+IL-6 (both 100 ng/ml). SCF seems therefore to act at least as a survival/proliferation factor for mesenchymal stem cells. Transdifferentiation potentialities towards endothelium were determined incubating L-NGFR+ cells in M199 supplemented with 10% FBS, 50 ng/ml VEGF, 1 ng/ml bFGF and 2 ng/ml IGF-1. At confluence, the cells were further purified using Ulex europaeus agglutinin-1 (UEA-1)-fluorescein isothiocyanate (FITC) and anti-FITC microbeads and expanded with VEGF. Immunophenotypic analysis of 8 samples showed a variable expression of endothelial markers: P1H12 ranging from 17 to 58%, CD105 from 98–100% and CD202b from 18 to 100%. L-NGFR+ cells, immediately after immunoseparation, were expressing Desmin but not MyoD, Miogenin, Mrf4, Myf5 by means of RT-PCR, while these cells were expressing NSE, TRKA and GalC, but not Nestin and GFAP. Experiments are ongoing to demonstrate muscle and neuron-glial differentiation in vitro using specific media (DMEM 10% FBS + 3 mM %-azacytidine, astrocyte conditioned media, neural stem cell conditioned media), In conclusion, the expression on NGFR+ cells of a variety of markers, not exclusively related to the mesenchymal lineage, and the reproducible ability to differentiate endothelial cells suggest that these cells may represent a subset of adult MSC with some multipotentiality.
7
Creasy, Caitlin A., Yuzhong Jeff Meng, Marie-Andrée Forget, Tatiana Karpinets, Katarzyna Tomczak, Chip Stewart, Carlos A. Torres-Cabala, et al. "Genomic Correlates of Outcome in Tumor-Infiltrating Lymphocyte Therapy for Metastatic Melanoma." Clinical Cancer Research 28, no. 9 (February 18, 2022): 1911–24. http://dx.doi.org/10.1158/1078-0432.ccr-21-1060.
Full textAbstract:
Abstract Purpose: Adoptive cell therapy (ACT) of tumor-infiltrating lymphocytes (TIL) historically yields a 40%–50% response rate in metastatic melanoma. However, the determinants of outcome are largely unknown. Experimental Design: We investigated tumor-based genomic correlates of overall survival (OS), progression-free survival (PFS), and response to therapy by interrogating tumor samples initially collected to generate TIL infusion products. Results: Whole-exome sequencing (WES) data from 64 samples indicated a positive correlation between neoantigen load and OS, but not PFS or response to therapy. RNA sequencing analysis of 34 samples showed that expression of PDE1C, RTKN2, and NGFR was enriched in responders who had improved PFS and OS. In contrast, the expression of ELFN1 was enriched in patients with unfavorable response, poor PFS and OS, whereas enhanced methylation of ELFN1 was observed in patients with favorable outcomes. Expression of ELFN1, NGFR, and PDE1C was mainly found in cancer-associated fibroblasts and endothelial cells in tumor tissues across different cancer types in publicly available single-cell RNA sequencing datasets, suggesting a role for elements of the tumor microenvironment in defining the outcome of TIL therapy. Conclusions: Our findings suggest that transcriptional features of melanomas correlate with outcomes after TIL therapy and may provide candidates to guide patient selection.
8
Takahashi, Mizuho, Akiharu Yoshino, Ayako Yamanaka, Chihiro Asanuma, Tadaaki Satou, Shinichiro Hayashi, Yoshinori Masuo, Kiyomi Sadamoto, and Kazuo Koike. "Effects of Inhaled Lavender Essential Oil on Stress-Loaded Animals: Changes in Anxiety-Related Behavior and Expression Levels of Selected mRNAs and Proteins." Natural Product Communications 7, no. 11 (November 2012): 1934578X1200701. http://dx.doi.org/10.1177/1934578x1200701132.
Full textAbstract:
Inhalation of various essential oils elicits behavioral changes as a consequence of a complex centrally coordinated response. To understand the molecular mechanisms of action of aromatic compounds on emotional responses, we evaluated the stress-induced changes in mouse brain and the efficacy of inhaled essential oil from Lavandula officinalis (LvEO) using two approaches: a behavioral test, and examining the expression levels of selected genes {fast nerve growth factor receptor (NGFR) mRNA, activity regulated cytoskeletal-associated protein (Arc) mRNA} and proteins {galactokinase 1 (GLK1) and brain-derived neurotrophic factor (BDNF)}. Animals were randomly divided into 4 groups depending on the treatment given: stress (-)/H2O, stress (-)/LvEO, stress (+)/H2O, and stress (+)/LvEO group. For behavioral testing, using an elevated plus-maze test, significant anxiolytic-like effects were seen in both the stress (-)/LvEO and stress (+)/LvEO groups, indicating that LvEO exerts anxiolytic-like effects regardless of the administration of water immersion stress. On expression analysis, the levels of NGFR and Arc mRNA were significantly lower in animals subjected to stress. Inhalation of LvEO, however, reversed this change, thus suggesting that LvEO negates the impact of stress on gene expression levels. Meanwhile, significant decreases in expression levels were also observed in the stress (-)/LvEO group, which implies that LvEO, when given in a stress-free situation, may act as a stress stimulus. Taken together, our data suggest that inhalation of LvEO exerts bidirectional influences in the central nervous system (CNS) of animals, either attenuating the effects of stress or acting as a stressor, depending on the subject state.
9
Nwozor, Agaptus, and Blessing Okhillu. "Child's Rights and the Challenges of Educating the Girl-Child: Assessing the Contributions of UNICEF in Nigeria." Age of Human Rights Journal, no. 18 (June 23, 2022): 285–309. http://dx.doi.org/10.17561/tahrj.v18.6520.
Full textAbstract:
In 2003, Nigeria domesticated the twin international instruments on child rights, the United Nations Convention on the Rights of the Child and the African Charter on the Rights and Welfare of the Child. The resultant legislation from Nigeria’s domestication efforts is the Child’s Rights Act (CRA) of 2003. Despite the provisions of this legislation detailing the elaborate atlas of rights to be enjoyed by the Nigerian child, their fortune especially that of the girl-child, has not got better. At the base of the contentious forces militating against the rights of the girl-child are the cultural and religious norms that are intrinsically embedded in the dominant patriarchal system prevalent in Nigeria, especially in northern Nigeria. These forces are intricately united in marginalizing and precluding the girl-child from accessing education. Using the lens of radical feminism in combination with human-rights based approach, this paper interrogates the challenges faced by the girl-child in accessing education and the interventionist role played by UNICEF to salvage the situation. The paper finds that although the interventionist program of UNICEF, that is, the Nigeria girls’ education project (NGEP), contributed in re-enrolling over one million out-of-school girls back to school, a lot needs to be done to salvage the girl-child from the doldrums of structural alienation that deprives her of access to education.
10
Failasufah, Failasufah, Farida Hanum, and Mohamad Hilmi Bin Mat Said. "Islamic Counseling Guidance As A Teenage Social Conflict Resolution In Madrasah." Edukasia Islamika 7, no. 2 (December 27, 2022): 232–50. http://dx.doi.org/10.28918/jei.v7i2.6277.
Full textAbstract:
This study aims to describe Islamic counseling guidance as conflict resolution carried out to help alleviate conflict problems and packaged as a psychological therapy procedure, becoming a strategic way that can be applied to resolve conflicts among adolescents, increase anti-violent and hostile behavior, and increase the use of resolution strategies. peaceful conflict. Conflict is a form of interaction between humans who have interests between the two, can be in the form of conflict, bickering, threats, or others with the aim of destroying the opponent. The method used in this study is qualitative. The results showed that, the occurrence of social conflicts among adolescent students in madrasas, conflicts experienced by adolescent students in madrasas began with the emergence of several students whose numbers were less than one percent of the number of students in madrasas involved in social groups or gangs. who act in the name of the “school gang” with all their activities, such as ngre-se or klitih, hanging out, fights, convoys, which occur because of the interests of social groups of adolescent students to show their existence. As a preventive and problem solving step, Islamic counseling guidance services as a conflict resolution aim to assist adolescent students in resolving conflict problems in peaceful ways.
Keywords: Islamic counseling guidance, conflict resolution, and conflict
11
Stavely, Rhian, Sukhada Bhave, Wing Lam N. Ho, Minhal Ahmed, Weikang Pan, Ahmed A. Rahman, Jessica Ulloa, et al. "Enteric mesenchymal cells support the growth of postnatal enteric neural stem cells." Stem Cells 39, no. 9 (May 8, 2021): 1236–52. http://dx.doi.org/10.1002/stem.3388.
Full textAbstract:
Abstract Interplay between embryonic enteric neural stem cells (ENSCs) and enteric mesenchymal cells (EMCs) in the embryonic gut is essential for normal development of the enteric nervous system. Disruption of these interactions underlies the pathogenesis of intestinal aganglionosis in Hirschsprung disease (HSCR). ENSC therapy has been proposed as a possible treatment for HSCR, but whether the survival and development of postnatal-derived ENSCs similarly rely on signals from the mesenchymal environment is unknown and has important implications for developing protocols to expand ENSCs for cell transplantation therapy. Enteric neural crest-derived cells (ENCDCs) and EMCs were cultured from the small intestine of Wnt1-Rosa26-tdTomato mice. EMCs promoted the expansion of ENCDCs 9.5-fold by inducing ENSC properties, including expression of Nes, Sox10, Sox2, and Ngfr. EMCs enhanced the neurosphere-forming ability of ENCDCs, and this persisted after withdrawal of the EMCs. These effects were mediated by paracrine factors and several ligands known to support neural stem cells were identified in EMCs. Using the optimized expansion procedures, neurospheres were generated from small intestine of the Ednrb −/− mouse model of HSCR. These ENSCs had similar proliferative and migratory capacity to Ednrb +/+ ENSCs, albeit neurospheres contained fewer neurons. ENSCs derived from Ednrb −/− mice generated functional neurons with similar calcium responses to Ednrb +/+ ENSCs and survived after transplantation into the aganglionic colon of Ednrb −/− recipients. EMCs act as supporting cells to ENSCs postnatally via an array of synergistically acting paracrine signaling factors. These properties can be leveraged to expand autologous ENSCs from patients with HSCR mutations for therapeutic application.
12
Le Clorennec, Christophe, Tan-Sothéa Ouk, Ibtissam Youlyouz-Marfak, Stéphanie Panteix, Catherine-Claude Martin, Julia Rastelli, Eric Adriaenssens, et al. "Molecular Basis of Cytotoxicity of Epstein-Barr Virus (EBV) Latent Membrane Protein 1 (LMP1) in EBV Latency III B Cells: LMP1 Induces Type II Ligand-Independent Autoactivation of CD95/Fas with Caspase 8-Mediated Apoptosis." Journal of Virology 82, no. 13 (April 30, 2008): 6721–33. http://dx.doi.org/10.1128/jvi.02250-07.
Full textAbstract:
ABSTRACT The Epstein-Barr virus (EBV) oncoprotein latent membrane protein 1 (LMP1) is thought to act as the major transforming protein in various cell types, by rerouting the tumor necrosis factor receptor family signaling pathway. Despite this implication in EBV-associated transformation of cells, LMP1 toxicity is a well-known but poorly studied feature, perhaps because it contradicts its role in transformation. We show that LMP1 physiological levels are very heterogeneous and that the highest levels of LMP1 correlate with Fas overexpression and spontaneous apoptosis in lymphoblastoid cell lines (LCLs). To understand the cytotoxic effect of LMP1 in LCLs, we cloned wild-type LMP1 into a doxycycline double-inducible episomal vector pRT-1, with a truncated version of NGFR as a surrogate marker of inducibility. We found that LMP1 overexpression induced apoptosis in LCL B cells, as shown by annexin V labeling, sub-G1 peak, and poly(ADP ribose) polymerase cleavage. Knocking down Fas expression by small interfering RNA abolished LMP1-induced apoptosis. The absence of detectable levels of Fas ligand mRNA suggested a ligand-independent activation of Fas. LMP1 induced Fas overexpression with its relocalization in lipid raft microdomains of the membrane. Fas immunoprecipitation detected FADD (Fas-associated death domain protein) and caspase 8, suggesting a Fas-dependent formation of the death-inducing signaling complex. Caspases 8, 9, 3, and 7 were activated by LMP1. Caspase 8 activation was associated with BID cleavage and truncated-BID mitochondrial relocalization, consistent with type II apoptosis. Therefore, our results are in agreement with a model where LMP1-dependent NF-κB activation induces Fas overexpression and autoactivation that could overwhelm the antiapoptotic effect of NF-κB, revealing an ambivalent function of LMP1 in cell survival and programmed cell death.
13
Amaria, Rodabe Navroze, Cara L. Haymaker, Chantale Bernatchez, Marie-Andree Forget, Vruti Patel, Wen-Jen Hwu, Michael A. Davies, et al. "A phase I/II study of lymphodepletion plus adoptive cell transfer (ACT) with T cells transduced with CXCR2 and NGFR followed by high dose interleukin-2 (IL-2) in patients with metastatic melanoma (MM)." Journal of Clinical Oncology 34, no. 15_suppl (May 20, 2016): TPS9594. http://dx.doi.org/10.1200/jco.2016.34.15_suppl.tps9594.
Full text
14
Roman, Petre. "The New Global Economy between a Well-Planned Journey and a Chaotic One. Under the Impact of both Climate Change and the Post Pandemic, the NGE: A More Complex and Less Predictable System." Environment and Pollution 11, no. 1 (March 9, 2022): 16. http://dx.doi.org/10.5539/ep.v11n1p16.
Full textAbstract:
The article is devoted to the understanding of the emergence of new traits of the global economy under the impact of climate change and the COVID pandemic. Economic research is nowadays primarily oriented towards the unpredictable and sometimes confusing situations related to the consequences of climate change. Global economy is a complex behavior with a new dynamic. If green energy is to be the main predictable feature we are confronted with three questions: is it robust, sustainable and resilient? The new global economy is not about a bright future; it is about selecting a positive norm that indicates today a positive behavior of it. Hydrogen fossil issue, electricity becoming a tradable commodity, the new role of nuclear energy as a crucial complement to renewables are among the main contributors in redesigning energy markets. We can safely say that by mid-century the world will need to remake its energy system. Indeed, while the science of climate change is today firmly established on powerful truths, the final outcome is not a simple extension of present-day trends. The environment, under the impact of climate change, is presently in a disordered phase of transition. Global disorder should not be inevitable even if critical thresholds seem to be inevitable. The obvious solution is cooperation out of what we believe to be true. We have to act in the presence of uncertainty and often that means that a better situation could be simply an unattainable one.
15
Young, Doug. "The impact of the Carbon Tax regime on the petroleum and gas industries." APPEA Journal 52, no. 1 (2012): 195. http://dx.doi.org/10.1071/aj11015.
Full textAbstract:
The Clean Energy Act (CEA) and its related legislation received royal assent on 18 November 2011, ushering in a new era for the Australian industry, and for those who deal with it. Building on the 2007 National Greenhouse and Energy Reporting Scheme (NGERS), which mandates the measurement and reporting of greenhouse gas emissions and electricity production and consumption, the CEA imposes direct obligations on: individual industrial operations (facilities) that emit more than 25,000 tonnes of carbon dioxide, or its other equivalent greenhouse gases, from particular sources, in a year; suppliers of natural gas (at the point of last supply before the gas is burnt or otherwise used), for the emissions that will be generated when the gas is burnt; and, operators of land-fill facilities, such as local councils. While the primary emissions targeted by the scheme are produced by burning fossil fuels, they also include emissions such as the methane released when coal is mined. The obligations include the option of surrendering carbon units for each tonne of emissions, however, if this optional step is not performed, the mandatory payment of a tax, which far exceeds the cost of a unit, is enforced. The Australian Government will sell carbon units at a fixed price for the first three years, starting at $23, after which units will be auctioned for between $15 and the expected international unit price, plus $20. The supply of domestic units will be unlimited for the three fixed price years, but will be subject to a reducing cap in following years, consistent with the Government policy of reducing Australia’s emissions. The Government has created a monopoly for the supply of units for the first three years by prohibiting the use of overseas-sourced carbon units, and by only allowing 5% of the unit surrender requirements to be comprised of Australian generated carbon credits. Thereafter, for the first five of the flexible-charge years, only half the units can be sourced from overseas, with any apparent saving likely to be offset by the various taxes and charges applicable to the use of those units. Certain fuels will also be separately taxed. Entities, however, which acquire, manufacture or import fuels and would otherwise be entitled to a fuel tax credit, may be able to assume direct liability thus enabling them to acquire or manufacture fuel, free of the carbon tax component. Where the imposts will cause competitive disadvantage to industries that compete with entities from other countries that do not have similar imposts, some assistance is provided in the form of allocated units provided at no charge. Assistance is also available to coal-fired electricity generators, producers of liquefied natural gas, operators of gassy coal mines, and the steel industry (not discussed in this paper). This paper also explains, in detail, how liability is created, how to determine which entities are liable, the means of assigning liability to other entities, and the assistance available to various industries to help deal with the financial impact of the scheme on their operations. It also outlines the key concepts that underpin the scheme.
16
Szczubiałka, Krzysztof, Anna Karewicz, Łukasz Moczek, Karolina Zomerska, and Maria Nowakowska. "Removal of Pentachlorophenol from Water Using Novel Smart Hydrogel Microspheres." e-Polymers 6, no. 1 (December 1, 2006). http://dx.doi.org/10.1515/epoly.2006.6.1.402.
Full textAbstract:
AbstractThe thermoresponsive hydrogel microspheres were obtained by copolymerization of N-isopropylacrylamide (NIPAM) and 2-hydroxyethyl methacrylate (HEMA) crosslinked with N,N’-methylenebisacrylamide (BIS). The hydrogel was then functionalized using 1-naphthyl glycidyl ether (NGE) to attach naphthyl chromophores, which absorb UV light and act as photosensitizers. The ability of the functionalized microspheres to photosensitize dechlorination reactions was confirmed using pentachlorophenol (PCP) as a model compound.
17
Mwamzandi, Mohamed. "A corpus study of Swahili conditionals." Studies in African Linguistics, June 1, 2017, 157–73. http://dx.doi.org/10.32473/sal.v46i1.107248.
Full textAbstract:
In this paper I analyze Swahili conditional constructions via corpus analysis. Previous works on Swahili conditional markers categorize ki as a high possibility marker and ikiwa as a low possibility marker. In this corpus based study, I show that Swahili conditional markers cannot be imbued with specific pragmatic implicatures. Further, I extend the analysis to include the relationship between the protasis and apodosis and how this relationship impacts the choice of Swahili conditional markers. Qualitative and quantitative analysis of the results indicate that both ki and ikiwa may be used in conditionals with a high as well as neutral possibility of realization. However, the conditional conjunction ikiwa significantly differs from the ki conditional morpheme in the analysis based on the relationship between the protasis and apodosis. While ki is more frequently used in content and speech act conditionals, ikiwa is more frequently used in epistemic conditionals. The study is also extended to include the Swahili subjunctive morphemes nge, used in conditionals with a low possibility of realization (hypotheticals) as well as counterfactuals, and ngeli/ngali, predominantly used in counterfactuals.
18
Yan, Jianyu, Chunji Li, Ning Zhang, Chunwang Li, Yunjiao Wang, and Bingxue Li. "Functional verification and characterization of a type-III geranylgeranyl diphosphate synthase gene from Sporobolomyces pararoseus NGR." Frontiers in Microbiology 13 (November 24, 2022). http://dx.doi.org/10.3389/fmicb.2022.1032234.
Full textAbstract:
Carotenoids, a group of natural pigments, have strong antioxidant properties and act as precursors to vitamin A, which have garnered attention from industry and researchers. Sporobolomyces pararoseus represents a hyper-producer of carotenoids, mainly including β–carotene, torulene, and torularhodin. Geranylgeranyl diphosphate synthase (GGPPS) is regarded as a key enzyme in the carotenoid biosynthesis pathway. However, the precise nature of the gene encoding GGPPS in S. pararoseus has not been reported yet. Here, we cloned a cDNA copy of the GGPPS protein-encoding gene crtE from S. pararoseus NGR. The crtE full-length genomic DNA and cDNA are 1,722 and 1,134 bp, respectively, which consist of 9 exons and 8 introns. This gene encodes 377 amino acids protein with a predicted molecular mass of 42.59 kDa and a PI of 5.66. Identification of the crtE gene encoding a functional GGPPS was performed using heterologous complementation detection in Escherichia coli. In vitro enzymatic activity experiments showed that CrtE utilized farnesyl diphosphate (FPP) as an allylic substrate for the condensation reaction with isopentenyl diphosphate (IPP), generating more of the unique product GGPP compared to other allylic substrates. The predicted CrtE 3D-model was analyzed in comparison with yeast GGPPS. The condensation reaction occurs in the cavity of the subunit, and three bulky amino acids (Tyr110, Phe111, and His141) below the cavity prevent further extension of the product. Our findings provide a new source of genes for carotenoid genetic engineering.
19
Hyman, Leonard S. "Electric Utility Privatization What We Can Learn from the British Experience." Distributed Generation & Alternative Energy Journal, April 4, 2022, 61–70. http://dx.doi.org/10.13052/dgaej2156-3306.1233.
Full textAbstract:
Privatization takes many forms . The act of privatization, how-ever , alway s involves "se lling st ate -owned assets to th e private sector,or ... allowing private en terpr ise to p erform functions pr eviouslyh andled by the st ate ."* That definition, of course, includes outsourcingof functions, or partn ering arra nge me nt s betw een th e gove rn me nt-owne d ent ity and a priv at e firm.Out sourcing is just a new word for contra cting out . Any well-m ana ged busine ss will en gag e an oth er firm to perform for it functionsthat it cannot p erform well on its own . That is ju st good business.Selling th e enti re gove rn me nt -owne d bu sin ess t o th e priv at e se ctor isth e most dramatic form of pri vatization. Gov ernm ent s wh ose busin essv entur es ar e disa st er s and govern me n ts in a d esp erat e hurr y to r ais emoney do not think about out sourcing. Th ey go all th e way .Th e m ost famous pr iv atiz ation effort, that of th e Thatch er gov-ern me nt, put th e conc ept on th e fr ont pag es. It embra ced priv atizationwith zeal. It pu sh ed out th e priv atization s with th e enormous gu st oa nd ferv or of th e tru e believer. Th e gove rn me nt r ak ed in billions ofp ounds . Millions of new inv estors bought sh ar es in dozen s of compa-nies. Th ose investors clean ed up, in most cas es .Is eve rybody happy ? Unfortunately, they are not. Tru e, theThatcher governm ent showed th at the governm ent could sell th edull est bu sinesses . The newly energized managements d emonstratedhow to r evitaliz e s e emin gly m oribund ent erpr is e s . But theprivatizati ons left a legacy of probl ems . We can le arn from th em .
20
Darmoyo, Syarief, Sri Hapsari Wijayanti, and Dara Arum Hartini. "PELATIHAN KETERAMPILAN MASTER OF CEREMONY BAGI WARGA RUSUNAWA MUARA BARU, JAKARTA." Jurnal Bakti Masyarakat Indonesia 5, no. 2 (September 1, 2022). http://dx.doi.org/10.24912/jbmi.v5i2.13456.
Full textAbstract:
ABSTRACT Public speaking does not just belong to celebrities; it belongs to all of us. Some of us have problems speaking in public, including the Rusunawa Muara Baru, Jakarta residents. The results of our needs analysis found that Rusunawa residents faced several issues related to public speaking. That was feeling anxious, not confident, "blank," stammering, unable to master the audience, etc., and they see the need to acquire speaking skills in front of the audience. For that, we held a community service in a master of ceremony (MC) training as a type of public speaking for the Rusunawa Muara Baru, Jakarta residents. This training applies small group discussion (SGD), role play & simulation, and contextual instruction (CI). The Faculty of Economics and Business lecturers, Atma Jaya Catholic University of Indonesia, act as facilitators. The results of this community service show that after participating in the training, the skills of MC participants are much better than their MC skills before participating in the activity. This condition implies that the trainees have an adequate understanding of the basic principles of being an MC and are skilled in programming and hosting events. In addition, this community service provides great benefits for training participants, such as broadening their horizons and increasing knowledge, equipping them with useful knowledge for educating children, etc ABSTRAK: Public speaking bukan hanya milik selebriti saja, melainkan milik kita semua. Meski begitu, tidak sedikit dari kita memiliki masalah berbicara di hadapan orang banyak, tidak terkecuali Warga Rusunawa Muara Baru, Jakarta Utara. Hasil analisis kebutuhan kami menemukan sejumlah masalah yang dihadapi Warga Rusunawa terkait public speaking yaitu, merasa cemas, tidak percaya diri, “nge-blank”, terbata-bata, tidak mampu menguasai audiens, dsb., dan mereka memandang perlu memperoleh pelatihan public speaking. Untuk itu, kami mengadakan pengabdian kepada masyarakat dalam bentuk pelatihan master of ceremony (MC) sebagai salah satu jenis public speaking bagi Warga Rusunawa Muara Baru, Jakarta Utara. Pelatihan ini mengaplikasikan metode diskusi kelompok kecil, bermain peran & simulasi, dan pembelajaran kontekstual, serta yang bertindak sebagai fasilitator adalah dosen-dosen Fakultas Ekonomi dan Bisnis Universitas Katolik Indonesia Atma Jaya. Hasil pengabdian kepada masyarakat ini menunjukkan bahwa setelah mengikuti pelatihan keterampilan MC peserta jauh lebih baik dibandingkan dengan keterampilan MC mereka sebelum mengikuti pelatihan. Hal ini mengimplikasikan bahwa peserta pelatihan sudah memiliki pemahaman yang memadai tentang prinsip dasar menjadi MC, serta sudah terampil dalam membuat susunan acara dan memandu acara. Selain itu, pengabdian kepada masyarakat ini memberikan manfaat yang besar bagi peserta pelatihan seperti memperluas wawasan dan menambah ilmu mereka, membekali mereka ilmu yang berguna untuk mendidik anak-anaknya, dsb