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Journal articles on the topic 'Niacinamide'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Rasis, Michal, Noa Ziklo, and Paul Salama. "Disruptive DNA Intercalation Is the Mode of Interaction Behind Niacinamide Antimicrobial Activity." Microorganisms 13, no. 7 (2025): 1636. https://doi.org/10.3390/microorganisms13071636.

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Niacinamide was recently shown to directly interact with bacterial DNA and interfere with cell replication; niacinamide mode of interaction and efficacy as a natural anti-microbial molecule were also described. The aim of this study is to elucidate the exact binding mechanism of niacinamide to microbial DNA. Intercalation is a binding mode where a small planar molecule, such as niacinamide, is inserted between base pairs, causing structural changes in the DNA. Melting curve analysis with various intercalating dyes demonstrated that niacinamide interaction with bacterial DNA reduces its melting

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2

Marques, Cíntia, Farid Hadjab, Alexandre Porcello, et al. "Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products." Antioxidants 13, no. 4 (2024): 425. http://dx.doi.org/10.3390/antiox13040425.

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Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role in NAD+ synthesis, notably contributing to redox reactions and energy production in cutaneous cells. Via diversified biochemical mechanisms, niacinamide is also known to influence human DNA repair and cellular stress responses. Based on decades of safe use in cosmetics, niacinamide recently gained widespread popularity as an active ingredient

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3

Sahu, Radhika, Kunal Sahu, Yogita Sahu, et al. "Overview of Acne, their Biochemical Relevance and Roles in Skin Health." INTERANTIONAL JOURNAL OF SCIENTIFIC RESEARCH IN ENGINEERING AND MANAGEMENT 08, no. 12 (2024): 1–8. https://doi.org/10.55041/ijsrem39675.

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Acne is a chronic inflammatory skin disorder that impacts both physical appearance and mental health in people of all ages. Niacinamide, or vitamin B3, has drawn interest recently as a potential supplementary or alternative treatment for acne because of its anti-inflammatory, antioxidant, and sebum-regulating qualities. This review's objective is to assess niacinamide's efficacy in treating acne by examining clinical research, its mode of action, and its safety profile. Several studies have shown that topical niacinamide can enhance skin barrier function, lessen inflammation, and lessen the se

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Yuniaswan, Anggun Putri, and Belladikna Brillianty Sugiatno. "The Effectiveness of 4% Niacinamide in A Case of Cutaneous Lupus." Jurnal Ilmiah Kedokteran Wijaya Kusuma 13, no. 2 (2024): 119. http://dx.doi.org/10.30742/jikw.v13i2.3592.

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Background: Niacinamide, also called nicotinamide, is the active form of niacin (nicotinic acid, vitamin B3). Niacinamide’s role in medicine continues to be studied due to its extensive effects and low toxicity. Various studies also suggest that niacinamide offers anti-inflammatory effects, improves the skin barrier, and acts as an anti-aging, brightening, and anticancer agent. Cutaneous lupus (CL) is a general term for a group of autoimmune connective tissue disorders affecting the skin that may be associated with systemic lupus erythematosus (SLE). There are plenty of treatment modalities fo

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5

Ziklo, Noa, Maayan Bibi, Lior Sinai, and Paul Salama. "Niacinamide Antimicrobial Efficacy and Its Mode of Action via Microbial Cell Cycle Arrest." Microorganisms 12, no. 8 (2024): 1581. http://dx.doi.org/10.3390/microorganisms12081581.

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Niacinamide is a versatile compound widely used in the personal care industry for its ample skin benefits. As a precursor to nicotinamide adenine dinucleotide (NAD+), essential for ATP production and a substrate for poly-ADP-ribose polymerase-1 (PARP-1), studies have highlighted its roles in DNA repair, cellular stress mechanisms, and anti-aging benefits. Niacinamide was also studied for its antimicrobial activity, particularly in the context of host-infection via host immune response, yet its direct antimicrobial activity and the mechanisms of action remain unclear. Its multifunctionality mak

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Permatasari, Nabila Jingga, and Sukmawati Tansil Tan. "Efektivitas Niacinamide Topikal terhadap Hidrasi Kulit pada Individu dengan Akne Vulgaris." Malahayati Nursing Journal 6, no. 12 (2024): 5143–50. http://dx.doi.org/10.33024/mnj.v6i12.15839.

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ABSTRACT Nowadays, many skincare products use niacinamide as their base ingredient. Niacinamide, also known as vitamin B3, has the potential to enhance ceramide synthesis and improve the skin barrier function. Due to those potentials, niacinamide can improve someone’s skin hydration level. To find out the efficacy of topical niacinamide on skin hydration levels on individuals with acne vulgaris. Through a quasi-experimental study design, this study was conducted for 21 days at 75 North Jakarta State High School with respondents of 59 people who are suffering from acne vulgaris. The method that

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7

Park, Ji Eun, and Young Mi Kim. "Effects of Black Vinegar and Niacinamide on LPS-Induced Inflammation on Human Keratinocytes." SDRP Journal of Cellular and Molecular Physiology 3, no. 2 (2020): 193–202. http://dx.doi.org/10.25177/jcmp.3.2.ra.10672.

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In this study, the effects of black vinegar (BA) and niacinamide on lipopolysaccharide (LPS)-treated human keratinocytes, HaCaT cells, were investigated. First of all, BA and niacinamide have no cytotoxicity in HaCaT cells even at high concentrations. LPS treatment triggers the phosphorylation of p38 mitogen-activated protein kinases (MAPK) and the expression of inflammatory enzymes, iNOS and COX-2. In contrast, BA and niacinamide weakened the expression of LPS-induced COX-2 and iNOS. Based on the results, we concluded that BA and niacinamide have effective anti-inflammatory properties in HaCa

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8

Rollando, Rollando. "PENGEMBANGAN SPEKTROFOTOMETER DERIVATIF DAN KEMOMETRIK MULTIVARIAT PADA SEDIAAN KOSMETIK YANG MENGANDUNG NIACINAMIDE DAN VITAMIN C PADA KOSMETIKA PENCERAH." Jurnal Wiyata: Penelitian Sains dan Kesehatan 10, no. 2 (2023): 23. http://dx.doi.org/10.56710/wiyata.v10i2.720.

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Niacinamide dan vitamin C merupakan senyawa yang banyak ditemukan di dalam kandungan kosmetika pencerah. Dimana keduanya memiliki efek yang baik pada kulit. Penelitian ini dilakukan dengan metode spektrofotometer derivatif dan kemometrik multivariat. Tujuan dilakukannya penelitian ini yaitu untuk mengetahui apakah validasi metode analisis dan kadar dari senyawa niacinamide dan vitamin C masih dalam batas pengunaannya. Pada metode kemometrik digunakan model Partial Least Square (PLS) dengan 25 set kalibrasi pada raw spektra dan derivatif 1 sampai 4. Validasi metode analisis memenuhi persyaratan

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9

Navarrete-Solís, Josefina, Juan Pablo Castanedo-Cázares, Bertha Torres-Álvarez, et al. "A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma." Dermatology Research and Practice 2011 (2011): 1–5. http://dx.doi.org/10.1155/2011/379173.

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Background. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes.Objective. To evaluate the therapeutic effect of topical niacinamide versus hydroquinone (HQ) in melasma patients.Patients and Methods. Twenty-seven melasma patients were randomized to receive for eight weeks 4% niacinamide cream on one side of the face, and 4% HQ cream on the other. Sunscreen was applied along the observation period. They were assessed by noninvasive techniques for the evaluation of s

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10

Young, Daniel O., Steven C. Cheng, James A. Delmez, and Daniel W. Coyne. "The Effect of Oral Niacinamide on Plasma Phosphorus Levels in Peritoneal Dialysis Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 29, no. 5 (2009): 562–67. http://dx.doi.org/10.1177/089686080902900515.

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Background Hyperphosphatemia remains a significant problem for patients requiring dialysis and is associated with increased mortality. Current treatment options include dietary restriction, dialysis, and phosphate binders. Treatment using the latter is frequently limited by cost, tolerability, and calcium loading. One open-label trial found niacinamide to be effective at decreasing serum phosphorus values in hemodialysis patients. Niacinamide may effectively reduce phosphorus levels in peritoneal dialysis (PD) patients already receiving standard phosphorus-lowering therapies. Methods An 8 week

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Takatsuki, Keigo, Shigeru Suzuki, Makiko Sato, Keiich Sakai, and Isamu Ushizawa. "Liquid Chromatographic Determination of Free and Added Niacin and Niacinamide in Beef and Pork." Journal of AOAC INTERNATIONAL 70, no. 4 (1987): 698–702. http://dx.doi.org/10.1093/jaoac/70.4.698.

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Abstract A simple liquid chromatographic (LC) method is described for the determination of free and added niacin and niacinamide in meats. A sample is homogenized and extracted with water, and the water extract is centrifuged, deproteinized with zinc hydroxide, and filtered first through a fluted paper and then through a microporous filter. The filtrate is subjected to liquid chromatography with UV detection at 263 nm. Different ion-pair systems are needed for the measurement of niacin and niacinamide on a reverse phase column. Methanolwater (1 + 9) containing 5mM tetrabutyl ammonium ion is us

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12

Somboon, Kamolrat, Choon-Peng Chng, Changjin Huang, and Shikhar Gupta. "Enhancing Niacinamide Skin Penetration via Other Skin Brightening Agents: A Molecular Dynamics Simulation Study." International Journal of Molecular Sciences 26, no. 4 (2025): 1555. https://doi.org/10.3390/ijms26041555.

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Niacinamide, a derivative of vitamin B3, has been shown to reduce skin pigmentation (i.e., acting as a brightening agent) and inflammatory responses such as dermatitis and acne vulgaris. However, niacinamide is a hydrophilic compound and poor partitioning to the lipid matrix in the uppermost layer of the skin (the stratum corneum or SC) limits its delivery to the skin. This necessitates the use of penetration enhancers to increase its bio-availability. In this study, we used computer simulations to investigate the skin penetration of niacinamide alone and in combination with other brightening

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13

Dewi, Fitri Jaya Santi Utami, Ilham Kuncahyo, and T. N. Saifullah. "Formula Development and Characterization Testing of Niacinamide Nano Liposomes as Anti Aging." Formosa Journal of Multidisciplinary Research 3, no. 9 (2024): 3407–26. http://dx.doi.org/10.55927/fjmr.v3i9.11223.

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Niacinamide has a mechanism of action as an anti-aging agent by increasing fibroblast production by stimulating collagen synthesis and can increase elastin which can prevent wrinkles on the skin of the facial area. The most commonly used method is thin layer hydration followed by sonication. Determination of the optimum formula using expert design with the simplex lattice design method. The purpose of the study was to determine the effect of Phosphatidylcholine concentration of 0.5-5% and Cholesterol concentration of 0.3-5% on the physical properties of niacinamide liposomes, obtain the optima

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14

Kaegi, Martin, Christian Adlhart, Markus Lehmann, Marius Risch, Werner Wessling, and Peter Klaffenbach. "A Novel Microfiber Wipe for Delivery of Active Substances to Human Skin: Clinical Proof of Concept." Polymers 12, no. 11 (2020): 2715. http://dx.doi.org/10.3390/polym12112715.

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A novel technology for the delivery of active substances to the skin based on microfibers loaded with dried active substances was developed. The objective of this work was to demonstrate deposition of the active substances on the skin including concurrent cleansing properties of the wipe. As model active substance to measure deposition capacity Niacinamide was used and as parameter to measure cleansing capacities of the wipe squalene uptake was measured. Wipes loaded with niacinamide were used in the face and the forearm of 25 subjects. By means of Raman spectrometry the deposited niacinamide

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15

Vu Thi Nhat, Le, Trang Vu Thi, and Thao Tran Thi Bich. "Simultaneous determination of nicotinamide mononucleotide, niacinamide, and nicotinic acid in health supplements using liquid chromatography method." Heavy metals and arsenic concentrations in water, agricultural soil, and rice in Ngan Son district, Bac Kan province, Vietnam 6, no. 4 (2023): 48–61. http://dx.doi.org/10.47866/2615-9252/vjfc.4160.

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This study aimed to develop and validate an HPLC-PDA method for simultaneous quantification of three compounds: nicotinamide mononucleotide (NMN), nicotinic acid, and niacinamide in dietary supplements. The sample preparation procedure was simple, fast, and used environmentally green extracted solvents. The HPLC conditions were as follows: C18 column (250 mm x 4.6 mm, 5 &micro;m); mobile phase: 10 mM phosphate buffer pH = 3: methanol (90:10, v/v), UV detection at wavelength 261 nm. The method met the AOAC criteria for validation, including selectivity, linearity (R2&gt; 0.999 for all a

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16

Yadav, Ekta. "Niacinamide and Coenzyme Q10: Molecular Insights into Skin Health, Longevity, and Optimized Cosmetic Formulations." Advance Research in Dermatology & Cosmetics (ARDC) 2, no. 1 (2023): 1–2. http://dx.doi.org/10.54026/ardc/1008.

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Niacinamide, a derivative of vitamin B3, and coenzyme Q10 (CoQ10), a component of the electron transport chain, are two molecules with potential benefits for skin health and longevity. This comprehensive review discusses the molecular mechanisms through which niacinamide and CoQ10 contribute to maintaining skin cell vitality and combating inflammatory stressors, both on the skin and within the body. Additionally, it highlights the synergy between these two ingredients in cosmetic formulations and potential interactions with other active ingredients. Evidence suggests that niacinamide and CoQ10

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17

Jo, Hyun-jun, Sang-Myoung Joo, Jeong Yup Kim, Kook-Hyun Yu, and Sang Wook Kim. "Development of a Hybrid Chitosan- and Niacinamide-Coupled ZnO Nanoparticle Composite for Sun Protection Application." Journal of Nanomaterials 2019 (November 16, 2019): 1–9. http://dx.doi.org/10.1155/2019/5957606.

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Zinc oxide nanoparticles (ZnO) have long been utilized as UV-protective sunscreen components due to their high durability and lower skin irritation while maintaining capability for blocking UV rays. However, the dispersal and transparency properties of ZnO need to be enhanced in order to improve the capacity for creating effective sunscreen through control of the physiochemical properties of ZnO. In this study, chitosan or niacinamide, which are suitable functional cosmetic compounds and effective skin lightening agents, are combined with ZnO for the development of better UV-protective product

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Aspadiah, Vica, Suryani, Wa Ode Sitti Zubaydah, Astrid Indalifiany, and Rahmat Muliadi. "Review: Perawatan Kulit dengan Niacinamide Sebagai Bahan Aktif." Lansau: Jurnal Ilmu Kefarmasian 1, no. 1 (2023): 69–76. http://dx.doi.org/10.33772/lansau.v1i1.8.

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Skincare is currently important because of the many problems that occur in the skin. Some of the problems that occur have caused a reaction from the community by using several skin care products that are believed to be able to overcome these problems. One of them is Niacinamide. This review aims to summarize the relevant literature on the role and potential of Niacinamide in various skin problems and to compare the results of studies from several articles. We summarize 21 articles obtained from PubMed and NCBI using several keywords. The review results show that Niacinamide is a substance that

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Madaan, Piyush, Priyanshi Sikka, and Deepinder Singh Malik. "Cosmeceutical Aptitudes of Niacinamide: A Review." Recent Advances in Anti-Infective Drug Discovery 16, no. 3 (2021): 196–208. http://dx.doi.org/10.2174/2772434416666211129105629.

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Background: The prevalence and scope of dermatological illness differ from region to region. Based upon type and severity, the conditions may vary from superficial to deep systemic skin infections. Niacinamide, an amide analog of vitamin B3 which was conventionally utilized as a food supplement, is now explored for the management of skin disorders. Being a powerhouse on its own, it is not stored inside the body naturally and has to be acquired from external sources. Areas covered: This review is an attempt to disclose the physiology, pharmacology, and highlight the dermatological potentials of

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Deng, Linglan, Shaobin Hao, Wanjie Zou, et al. "Effects of Supplementing Growing–Finishing Crossbred Pigs with Glycerin, Vitamin C and Niacinamide on Carcass Characteristics and Meat Quality." Animals 13, no. 23 (2023): 3635. http://dx.doi.org/10.3390/ani13233635.

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The objective of this study was to determine the influence of supplementing the diet of growing–finishing pigs with glycerin and/or a mixture of vitamin C and niacinamide on carcass traits and pork quality. Eighty-four weaned piglets with an initial average body weight of 20.35 ± 2.14 kg were assigned, at random, to four groups for a 103-day feeding experiment: control; glycerin-supplemented group; vitamin C and niacinamide-supplemented group; and glycerin, vitamin C and niacinamide-supplemented group. At the end of the experiment, three pigs/group were randomly selected and slaughtered, and s

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Wawrzyńczak, Agata, Izabela Nowak, and Agnieszka Feliczak-Guzik. "SBA-15- and SBA-16-Functionalized Silicas as New Carriers of Niacinamide." International Journal of Molecular Sciences 24, no. 24 (2023): 17567. http://dx.doi.org/10.3390/ijms242417567.

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Amorphous silica as a food additive (E 551) is used in food materials (e.g., sweeteners, dairy products) for its anti-caking properties. The physicochemical properties of SiO2 also make it suitable to serve as a carrier of active substances in functional foods, dietary supplements, and drugs. Deficiency of niacinamide (vitamin B3, niacin) leads to several pathologies in the nervous system and causes one of the nutritional diseases called pellagra. The present study focuses on the use of hybrid ordered mesoporous silicas (SBA-15/SBA-16) functionalized with amino groups introduced through grafti

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Sarangi, Bandita, Sanat K. Chatterjee, Kajal Dutta, and Saroj K. Das. "Thin Layer Chromatographic Identification and Quantitation of Niacin and Niacinamide in Pharmaceutical Preparations." Journal of AOAC INTERNATIONAL 68, no. 3 (1985): 547–48. http://dx.doi.org/10.1093/jaoac/68.3.547.

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Abstract A safe and simple thin layer chromatographic method has been developed for the estimation of niacin and niacinamide in pharmaceutical preparations containing other vitamins, enzymes, herbs, antiamoebic drugs, etc. The method involves removal of excipients from the preparation by ethanol precipitation and isolation of niacin or niacinamide from other ingredients by TLC on silica gel with water as developing solvent, followed by extraction in 0.1N HC1, and spectrophotometric estimation of the vitamin at 262 nm. The percent recoveries for niacin and niacinamide were 100.1 ± 1.9 and 100.2

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Leonita, Eden, Trisniartami Setyaningrum, Mohammad Fathul Qorib, and Damayanti -. "Comparison of the Efficacy of Topical Clindamycin versus Niacinamide in the Treatment of Mild to Moderate Acne Vulgaris: a Systematic Review." Berkala Ilmu Kesehatan Kulit dan Kelamin 34, no. 1 (2022): 15–22. http://dx.doi.org/10.20473/bikk.v34.1.2022.15-22.

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Background: Acne vulgaris (AV) is one of the most common skin diseases among teenagers and is treated based on its severity. Mild acne is treated with topical agents, while moderate and severe acne are treated with a combination of topical and systemic agents. Topical agents that are often used for acne are antibiotics, such as topical clindamycin. Widespread use of antibiotics to treat AV causes resistance problems. Therefore, alternative therapies are needed to prevent resistance to topical clindamycin, such as topical niacinamide, which has anti-inflammatory effects without inducing resista

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Nabila Jingga Permatasari and Sukmawati Tansil Tan. "Efficacy of Topical Niacinamide on Skin Hydration of Adolescents with Acne Vulgaris: An Experimental Study on the Adolescent Community in Jakarta, Indonesia." Bioscientia Medicina : Journal of Biomedicine and Translational Research 8, no. 9 (2024): 4987–95. http://dx.doi.org/10.37275/bsm.v8i9.1078.

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Background: Acne vulgaris (AV) is a chronic inflammatory skin disorder common in adolescents, often accompanied by dry, irritated skin. Topical niacinamide (vitamin B3) has shown potential in increasing skin hydration and reducing AV symptoms. This study aims to evaluate the efficacy of topical niacinamide on skin hydration in adolescents with AV in Jakarta, Indonesia. Methods: This research is a randomized controlled experimental study involving 100 adolescents (14-19 years) with mild to moderate AV in Jakarta. Participants were randomly divided into two groups: the intervention group (receiv

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Nurrosyidah, Jihan, Aqnes Budiarti, and Khoirul Anwar. "High Performance Liquid Chromatography Method for Analysis of Alpha Arbutin and Niacinamide in Facial Whitening Creams." Journal Pharmasci (Journal of Pharmacy and Science) 9, no. 1 (2024): 41–48. http://dx.doi.org/10.53342/pharmasci.v9i1.374.

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The combination of alpha arbutin and niacinamide is often used in facial whitening creams at relatively small levels so required valid analysis method. This study aimed to develop HPLC method for analyzing alpha arbutin and niacinamide in three brands of whitening creams. The HPLC system developed was a reverse phase type with a C₁₈ column and the mobile phase was a mixture of metanol: aquabidest (20:80, v/v) with a flow rate of 1.0 ml/min and a detection wavelength of 274 nm. The results showed that all parameters met the requirements. The linearity test yielded a correlation value was r= 0.9

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Mueller, Ralf S., Rodney A. W. Rosychuk, and Leonard D. Jonas. "A Retrospective Study Regarding the Treatment of Lupoid Onychodystrophy in 30 Dogs and Literature Review." Journal of the American Animal Hospital Association 39, no. 2 (2003): 139–50. http://dx.doi.org/10.5326/0390139.

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The treatment records of 30 dogs with lupoid onychodystrophy were evaluated retrospectively. Dogs were treated with fatty acid supplementation (n=18), doxycycline and niacinamide (n=12), tetracycline and niacinamide (n=10), pentoxifylline (n=6), prednisolone (n=5), azathioprine (n=1), clofazimine (n=1), or with combinations thereof. An excellent response was seen in almost half of the patients treated with tetra- or doxycycline in combination with niacinamide. Six of the dogs were maintained successfully on fatty acid supplementation. Spontaneous remissions and recurrences made evaluation of s

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Pedroso, Adriana Giomo, Gisele Rosada Dônola Furtado, and Kledson Lopes Barbosa. "Niacinamide for the treatment of melasma: an integrative review of randomized clinical trials." Research, Society and Development 11, no. 11 (2022): e198111133581. http://dx.doi.org/10.33448/rsd-v11i11.33581.

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Introduction: Melasma is a very common and difficult to treat hypermelanosis because it usually responds poorly to therapies, negatively affecting the quality of life of patients. Objective: to know and analyze the scientific evidence related to the treatment of patients with facial melasma treated with niacinamide. Method: a literature review was performed based on a data search in BIREME, PubMed, SciELO and ScienceDirect. Articles indexed in these electronic journals were included in the time frame from 2011 to 2019. Results: Evidence analyzes revealed a major impact on the appearance of fac

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Teradale, A. B., S. D. Lamani, B. E. Kumara Swamy, P. S. Ganesh, and S. N. Das. "Electrochemical Investigation of Catechol at Poly(niacinamide) Modified Carbon Paste Electrode: A Voltammetric Study." Advances in Physical Chemistry 2016 (November 7, 2016): 1–8. http://dx.doi.org/10.1155/2016/8092860.

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A polymeric thin film modified electrode, that is, poly(niacinamide) modified carbon paste electrode (MCPE), was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. Compared to bare carbon paste electrode (BCPE), the poly(niacinamide) MCPE shows good electrocatalytic activity towards the oxidation of catechol in phosphate buffer solution (PBS) of physiological pH 7.4. All experimental parameters were optimized. Poly(niacinamide) modified carbon paste electrode gave a linear response between concentration of CC and its anodic peak current in

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Zhao, Yan, Fangli Tang, Yunlong Shi, et al. "Functional Requirement of Niacinamide for Blood Profiles, Antioxidant Status, and Intestinal Health in Finishing Pigs Fed a Low-Protein Diet." Animals 15, no. 12 (2025): 1813. https://doi.org/10.3390/ani15121813.

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This study investigated the effects of dietary niacinamide supplementation on blood parameters, antioxidant status, and intestinal health in finishing pigs fed low-protein diets. Sixty-four pigs (Duroc × Landrace × Yorkshire; 80.4 ± 0.1 kg) were randomly allocated to four dietary treatments supplemented with 30 (NAM30), 130 (NAM130), 230 (NAM230), and 330 (NAM330) mg/kg niacinamide for 30 days. Each treatment had four replicate pens and four pigs per pen. Growth performance was not significantly affected. However, the NAM130 group showed higher (p < 0.05) hemoglobin levels, reduced (p <

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suriyanarayanan, Ramesh, Gurumallappa Shivakumar Hosakote, and Shivanandappa Nagaraja. "Effect of Different Diffusion Membranes on the Diffusion Rate of Niacinamide and Diclofenac Sodium From Topical Formulations." Pharmaceutical Methods 7, no. 2 (2016): 94–98. https://doi.org/10.5281/zenodo.14857974.

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The aim of the study was to correlate diffusivity of Niacinamide from a cream formulation and Diclofenac sodium from a gel formulation. Evaluation is done by in vitro drug release through Franz diffusion cell and different diffusion membranes. The membranes used for the study were Polytetrafluoroethylene (PTFE), Polyvinylidene fluoride (PVDF) and Dialysis membranes. Phosphate buffer pH 5.5 was the receptor medium. Studies showed significant variations in the diffusion rate of niacinamide and Diclofenac sodium across different membranes. The percentage of Niacinamide diffused from niacinamide c

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Maheshwari, R. K., Apeksha Apte, and Om Prakash Agrawal. "Spectrophotometric analysis of tablets of nalidixic acid using melted niacinamide as solvent." Journal of Drug Delivery and Therapeutics 9, no. 1-s (2019): 206–8. http://dx.doi.org/10.22270/jddt.v9i1-s.2323.

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In the current attempt of research, novel method for spectrophotometric estimation of nalidixic acid in tablets using melted niacinamide as solvent was developed. The main objective behind research is to show “SOLIDS ALSO POSSESS SOLUBILIZING POWER”. The current study deals with novel spectrophotometric analytical technique for quantitative estimation of nalidixic acid in tablets using melted niacinamide as solvent. According to the theory proposed by Maheshwari, each & every substance possesses solubilising power; substance may be a gas, solid or liquid. Niacinamide imbibes large solubili

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Anggraini Putri, Dhea, and Pirim Setiarso. "Fabrication of carbon pasta elektroda composition modified with nanobentonite and nano TiO2 for niacinamide detection sensor." Jurnal Pijar Mipa 18, no. 6 (2023): 923–28. http://dx.doi.org/10.29303/jpm.v18i6.5847.

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Niacinamide is the amide form of vitamin B3, which is usually analyzed for concentration using UV-Vis Spectrophotometry, HPLC, and KLT. The development of niacinamide analysis methods using cyclic voltammetry has not been widely studied. The use of working electrodes in cyclic voltammetry is usually carbon paste electrodes. However, these electrodes have disadvantages, relatively low sensitivity and slower electron transfer kinetics, so it is necessary to research working electrode modification to increase electrode sensitivity. This study aims to determine the effect of the addition of nanobe

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Wei, Panting, Wenchen Sun, Shaobin Hao, et al. "Dietary Supplementation of Crossbred Pigs with Glycerol, Vitamin C, and Niacinamide Alters the Composition of Gut Flora and Gut Flora-Derived Metabolites." Animals 14, no. 15 (2024): 2198. http://dx.doi.org/10.3390/ani14152198.

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The addition of glycerin, vitamin C, and niacinamide to pig diets increased the redness of longissimus dorsi; however, it remains unclear how these supplements affect gut microbiota and metabolites. A total of 84 piglets (20.35 ± 2.14 kg) were randomly allotted to groups A (control), B (glycerin-supplemented), C (vitamin C and niacinamide-supplemented), and D (glycerin, vitamin C and niacinamide-supplemented) during a feeding experiment. Metagenomic and metabolomic technologies were used to analyze the fecal compositions of bile acids, metabolites, and microbiota. The results showed that compa

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et al., Park. "Aqueous solubility of high concentrated caffeine using hydrotrope and the application to the anti-cellulite cosmetics." International Journal of ADVANCED AND APPLIED SCIENCES 9, no. 6 (2022): 79–85. http://dx.doi.org/10.21833/ijaas.2022.06.010.

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This study presents measurements of the aqueous solubility of caffeine at a temperature ranging from 5 to 40°C. And the low water solubility of caffeine was increased by using a hydrotropic solubilization system. Solubility was measured with a single hydrotropic system of niacinamide or betaine and a mixed hydrotropic system of niacinamide and betaine. As a result, it was possible to prepare a high-concentration aqueous caffeine solution of about 4% at 5.9°C and about 25% at 39.9°C. The modified Apelblat equation was applied to predict the temperature dependence of caffeine solubility in aqueo

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Hadjab, F. "AB0046 RESISTANCE TO OXIDATIVE DEGRADATION OF A FORMULATION COMBINING HYALURONIC ACID AND NIACINAMIDE." Annals of the Rheumatic Diseases 81, Suppl 1 (2022): 1158.1–1158. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1074.

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BackgroundHyaluronic acid plays a major role in the homeostasis of cartilage. In cases of osteoarthritis, hyaluronic acid is subjected to significant oxidative stress linked to the inflammation cascade leading to drastic diminution of its quantity at the level of the joint. This decrease in hyaluronic acid reduces dramatically the lubricating properties of the synovial fluid.Several preparation methods have been developed to further stabilize the hyaluronic acid used as viscosupplement such as crosslinking or adding adjuvants.ObjectivesA new formulation intended for intra-articular administrat

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Yilmaz, Cigdem Kemal. "Ingredient focus: niacinamide." Journal of Aesthetic Nursing 13, no. 5 (2024): 210–13. http://dx.doi.org/10.12968/joan.2024.0037.

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Campuzano-García, Andres Eduardo, Bertha Torres-Alvarez, Diana Hernández-Blanco, Cornelia Fuentes-Ahumada, Juan Diego Cortés-García, and Juan Pablo Castanedo-Cázares. "DNA Methyltransferases in Malar Melasma and Their Modification by Sunscreen in Combination with 4% Niacinamide, 0.05% Retinoic Acid, or Placebo." BioMed Research International 2019 (April 22, 2019): 1–7. http://dx.doi.org/10.1155/2019/9068314.

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Background. Malar melasma has a chronic and recurrent character that may be related to epigenetic changes. Objective. To recognize the expression and DNA methylation of DNA methyltransferases (DNMTs) in malar melasma and perilesional skin, as well as the changes in DNMTs after their treatment with sunscreen in combination with 4% niacinamide, 0.05% retinoic acid, or placebo. Methods. Thirty female patients were clinically evaluated for the expression of DNMT1 and DNMT3b using real-time PCR and immunofluorescence. These initial results were compared to results after eight weeks of treatment wit

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Lee, Seungyeon, Geunjeong Lee, Giyoung Jeon, et al. "Anti-Aging and Lightening Effects of Au-Decorated Zeolite-Based Biocompatible Nanocomposites in Epidermal Delivery Systems." Journal of Functional Biomaterials 14, no. 2 (2023): 66. http://dx.doi.org/10.3390/jfb14020066.

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The main challenges in developing zeolites as cosmetic drug delivery systems are their cytotoxicities and the formation of drug-loading pore structures. In this study, Au-decorated zeolite nanocomposites were synthesized as an epidermal delivery system. Thus, 50 nm-sized Au nanoparticles were successfully deposited on zeolite 13X (super cage (α) and sodalite (β) cage structures) using the Turkevich method. Various cosmetic drugs, such as niacinamide, sulforaphane, and adenosine, were loaded under in vitro and in vivo observations. The Au-decorated zeolite nanocomposites exhibited effective cos

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Udraite Vovk, Laura, Christoph J. Klinger, Teresa M. S. A. Böhm, Natalie K. Y. Gedon, Sonya V. Bettenay, and Ralf S. Mueller. "Successful treatment of a mucous membrane pemphigoid in a young dog." Tierärztliche Praxis Ausgabe K: Kleintiere / Heimtiere 47, no. 05 (2019): 1–8. http://dx.doi.org/10.1055/a-1000-5121.

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AbstractMucous membrane pemphigoid was diagnosed in a 2.5-year-old male intact foxhound-beagle cross which was presented with an acute onset of non-pruritic, multifocal, slowly progressive erosive-ulcerative dermatitis predominantly affecting the nasal planum, eyelids and muzzle with multiple vesicles on the inner pinnae, oral mucosa and tongue. The diagnosis was based on clinical signs and histological examination of skin biopsies. The patient did not respond to immunosuppressive prednisolone therapy, but went into complete remission with oral doxycycline and niacinamide and stayed in remissi

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Wang, Lei-lei, An-ping Chen, Jian-ying Li, Zhuo Sun, Shi-liang Yan, and Kai-yuan Xu. "Mechanism of the Effect of High-Intensity Training on Urinary Metabolism in Female Water Polo Players Based on UHPLC-MS Non-Targeted Metabolomics Technique." Healthcare 9, no. 4 (2021): 381. http://dx.doi.org/10.3390/healthcare9040381.

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Objective: To study the changes in urine metabolism in female water polo players before and after high-intensity training by using ultra-high performance liquid chromatography-mass spectrometry, and to explore the biometabolic characteristics of urine after training and competition. Methods: Twelve young female water polo players (except goalkeepers) from Shanxi Province were selected. A 4-week formal training was started after 1 week of acclimatization according to experimental requirements. Urine samples (5 mL) were collected before formal training, early morning after 4 weeks of training, a

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Gehring, W. "Nicotinic acid/niacinamide and the skin." Journal of Cosmetic Dermatology 3, no. 2 (2004): 88–93. http://dx.doi.org/10.1111/j.1473-2130.2004.00115.x.

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TREMBLAY, JEAN-FRANÇOIS. "Lonza niacinamide plant opens in China." Chemical & Engineering News 77, no. 43 (1999): 24. http://dx.doi.org/10.1021/cen-v077n043.p024.

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Woollard, David C., and Harvey E. Indyk. "Rapid Determination of Thiamine, Riboflavin, Pyridoxine, and Niacinamide in Infant Formulas by Liquid Chromatography." Journal of AOAC INTERNATIONAL 85, no. 4 (2002): 945–51. http://dx.doi.org/10.1093/jaoac/85.4.945.

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Abstract A simplified, simultaneous determination of vitamins B1, B2, B3, and B6 in supplemented infant formulas was developed from a single deproteinized sample extract, with analysis by reversed-phase, ion-pair chromatography with an acidified methanol–water mobile phase. The dioctylsulfosuccinate counter-ion facilitates unique retention of the pyridine-based vitamins (niacinamide and pyridoxine) and allows for concurrent measurement of both the pyridoxal and riboflavin 5′-phosphate endogenous components of milk. Other naturally occurring undetected vitamin congeners have minimal analytical

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Carpenter, Garima, and R. K. Maheshwari. "Formulation and development of fast dissolving oral film of a poorly soluble drug, frusemide with improved drug loading using mixed solvency concept and its evaluation." Journal of Drug Delivery and Therapeutics 8, no. 6 (2018): 132–41. http://dx.doi.org/10.22270/jddt.v8i6.2034.

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The aim of the present research work is to explore the application of mixed solvency concept to formulate and develop a fast dissolving oral film of furosemide with improved drug loading. In the present study, poorly soluble drug, furosemide was tried to be solubilized by employing the combination of physiologically compatible water-soluble additives (solubilizers) to formulate its fast dissolving formulations. For the development of fast dissolving oral film, firstly, different film forming polymers were tested for their film properties. The second fast dissolving layer was also formed and op

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Smiljanic, Sandra, Cyril Messaraa, Virginie Lafon-Kolb, et al. "Betula alba Bark Extract and Empetrum nigrum Fruit Juice, a Natural Alternative to Niacinamide for Skin Barrier Benefits." International Journal of Molecular Sciences 23, no. 20 (2022): 12507. http://dx.doi.org/10.3390/ijms232012507.

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The Scandinavian region is home to a unique biome with endemic plant species. The aim of this study was to explore this natural diversity and identify plant extracts providing positive skin barrier effects. Six plant extracts were identified as starting material. Following biochemical screening, two candidates outperformed the rest: Betula alba (BA) and Empetrum nigrum (EN). Quantitative PCR analysis showed that BA and EN upregulated barrier genes, when used individually and in combination. Betula alba increased AQP3 and OCLN protein expression, something niacinamide was incapable of. Addition

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Rusic, Doris, Magdalena Ivic, Ana Slugan, et al. "Pilot Study on the Effects of a Cosmetic Serum Containing Niacinamide, Postbiotics and Peptides on Facial Skin in Healthy Participants: A Randomized Controlled Trial." Life 14, no. 12 (2024): 1677. https://doi.org/10.3390/life14121677.

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The literature describes niacinamide, but also postbiotics and peptides, as ingredients that improve skin barrier function, but also affect melanin and sebum levels in individuals. However, the combined effects of these ingredients in a single cosmetic serum have not been sufficiently investigated. Therefore, the aim of this randomized controlled study, conducted at the University of Split School of Medicine (Croatia), was to evaluate the effects of cosmetic products containing these active ingredients. This study was registered with ClinicalTrials.gov (NCT06189105) and has been completed. Pri

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Siti Aulia Nurmedina, Dewi Sagita, and Syamsul Hidayat. "Persepsi Remaja Perempuan pada Produk Pemutih Niacinamide." JURNAL RISET MANAJEMEN DAN EKONOMI (JRIME) 3, no. 1 (2024): 253–64. https://doi.org/10.54066/jrime-itb.v3i1.2846.

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This study aims to analyze adolescent girls' perceptions of skin whitening products containing niacinamide, an active ingredient known to have skin brightening and hyperpigmentation reduction benefits. This study used a quantitative approach with a survey method, involving 100 adolescent girls aged 15-21 years old in the city of Serang. Data was collected through a questionnaire that measured factors such as brand awareness, belief in product benefits, and the influence of social media in purchasing decisions. The results showed that the majority of respondents had positive perceptions of prod

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Amengual, Jennifer E., Matko Kalac, Luigi Scotto, et al. "Therapeutic Targeting of the Bcl-6: p53 Axis with Histone Deacetylase Inhibitors in Diffuse Large B-Cell Lymphoma,." Blood 118, no. 21 (2011): 3733. http://dx.doi.org/10.1182/blood.v118.21.3733.3733.

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Abstract Abstract 3733 Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin's Lymphoma. Despite advances in treatment, 1/3 of patients die from their disease. Gene expression profiling has delineated three subtypes with different genetic features known to be prognostic: the Activated B-cell (ABC), Germinal Center (GC), and grey zone types. For example, ABC DLBCL is addicted to NFkB over-expression. The oncogene, BCL6, encodes a transcription factor that functions as a transcriptional repressor within normal germinal center B-cells. Constitutive activation of Bcl-6 leads to GC-t

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Zhang, Yanling, Chin-Ping Kung, Fotis Iliopoulos, Bruno C. Sil, Jonathan Hadgraft, and Majella E. Lane. "Dermal Delivery of Niacinamide—In Vivo Studies." Pharmaceutics 13, no. 5 (2021): 726. http://dx.doi.org/10.3390/pharmaceutics13050726.

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In vivo human studies are considered to be the “gold standard” when investigating (trans)dermal delivery of actives. Previously, we reported the effects of a range of vehicles on the delivery of niacinamide (NIA) using conventional Franz cell studies. In the present work, dermal delivery of NIA was investigated in vivo in human subjects using confocal Raman spectroscopy (CRS) and tape stripping (TS). The vehicles investigated included propylene glycol (PG), Transcutol® P (TC), binary combinations of PG with oleic acid (OA) or linolenic acid (LA) and a ternary system comprising of TC, caprylic/

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Spector, Reynold. "Niacinamide transport through the blood-brain barrier." Neurochemical Research 12, no. 1 (1987): 27–31. http://dx.doi.org/10.1007/bf00971360.

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