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Journal articles on the topic 'Niches (Architecture)'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 August 2024

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1

Peng, Minghao, and Ruoshui Li. "Additional niches and architecture added in the Tang dynasty to the Vairocana niche in the Fengxian Temple at Longmen." Chinese Archaeology 22, no. 1 (2022): 182–90. http://dx.doi.org/10.1515/char-2022-0015.

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Abstract The niche with the colossal statue of Vairocana Buddha in the Fengxian Temple in Longmen was carved in the second year of the Shangyuan reign period of the Tang dynasty. At the beginning of the Kaiyuan reign, additional niches were carved into the same cliff wall. Based on spatial analysis of the surviving holes for architectural structures and their relation to the niches added later, it is inferred that the architecture in front of the niche was not built after the construction of these later niches. These two construction events could have belonged to the same construction phase. T

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FİDAN, Mevlüt Anıl, and Ali BAŞ. "The Crown Gate Side Niches in Karamanoğlu Madrasahs." Selçuk Üniversitesi Edebiyat Fakültesi Dergisi, no. 47 (June 15, 2022): 199–218. http://dx.doi.org/10.21497/sefad.1128576.

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In the architecture of the Anatolian Seljuk period and its innovative successor, the Principalities, front facade establishments; It consists of elements such as crown doors, windows, niches, moldings, buttresses, corner towers, gargoyles and minarets. Crown doors, which are located on the front facades of the buildings, which are given more importance than the other facades, become more prominent than other facade elements with their unique differences. In this study, our focus is the niches placed inside the side walls that delimit the main niche of the portals. Side niches resembling a port

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Evans, H. F., and M. R. Jukes. "The role of niche availability as a factor determining the diversity and abundance of invertebrates on Scots pine, Pinus sylvestris." Forest Systems 9 (January 1, 2000): 273–95. http://dx.doi.org/10.5424/688.

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We review aspects of invertebrate biodiversity relevant to the management of Scots pine forests. At a landscape level, the area occupied by the host tree species, the length of time that species has been present, and the taxonomic relatedness of the host to other trees, all influence invertebrate biodiversity. At a stand level, tree size and above-ground architecture affect the number of niches available. Consideration needs to be given to the various feeding guilds since they exploit different components of these niches. Although there have been few published studies of invertebrate numbers i

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Bardelli, Silvana, and Marco Moccetti. "Remodeling the Human Adult Stem Cell Niche for Regenerative Medicine Applications." Stem Cells International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/6406025.

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The interactions between stem cells and their surrounding microenvironment are pivotal to determine tissue homeostasis and stem cell renewal or differentiation and regenerationin vivo. Ever since they were postulated in 1978, stem cell niches have been identified and characterized in many germline and adult tissues. Comprehensive studies over the last decades helped to clarify the critical components of stem cell niches that include cellular, extracellular, biochemical, molecular, and physical regulators. This knowledge has direct impact on their inherent regenerative potential. Clinical appli

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Fatyushyna, N. Yu. "Basic features of early Christian art (painting, mosaic, architecture, music)." Ukrainian Religious Studies, no. 25 (December 27, 2002): 110–17. http://dx.doi.org/10.32420/2003.25.1434.

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The most ancient monuments of ancient Christian art were found in catacombs located outside the cities. The Christian catacombs were a complex plexus of underground narrow galleries with numerous niches where the coffins of martyrs and bishops were placed. These niches formed a kind of rectangular chambers, the walls and surfaces of which were decorated with images. Thus, early Christian art begins with catacomb paintings.

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Laughlin, Daniel C., and Brian J. McGill. "Trees have overlapping potential niches that extend beyond their realized niches." Science 385, no. 6704 (2024): 75–80. http://dx.doi.org/10.1126/science.adm8671.

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Tree species appear to prefer distinct climatic conditions, but the true nature of these preferences is obscured by species interactions and dispersal, which limit species’ ranges. We quantified realized and potential thermal niches of 188 North American tree species to conduct a continental-scale test of the architecture of niches. We found strong and consistent evidence that species occurring at thermal extremes occupy less than three-quarters of their potential niches, and species’ potential niches overlap at a mean annual temperature of ~12°C. These results clarify the breadth of thermal t

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Crittenden, Sarah L., ChangHwan Lee, Ipsita Mohanty, Sindhu Battula, Karla Knobel, and Judith Kimble. "Sexual dimorphism of niche architecture and regulation of the Caenorhabditis elegans germline stem cell pool." Molecular Biology of the Cell 30, no. 14 (2019): 1757–69. http://dx.doi.org/10.1091/mbc.e19-03-0164.

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Stem cell maintenance by niche signaling is a common theme across phylogeny. In the Caenorhabditis elegans gonad, the broad outlines of germline stem cell (GSC) regulation are the same for both sexes: GLP-1/Notch signaling from the mesenchymal distal tip cell niche maintains GSCs in the distal gonad of both sexes and does so via two key stem cell regulators, SYGL-1 and LST-1. Yet most recent analyses of niche signaling and GSC regulation have focused on XX hermaphrodites, an essentially female sex making sperm in larvae and oocytes in adults. Here we focus on GSC regulation in XO males. Sexual

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Ramirez-Figueroa, Carolina, and Richard Beckett. "Living with buildings, living with microbes: probiosis and architecture." Architectural Research Quarterly 24, no. 2 (2020): 155–68. http://dx.doi.org/10.1017/s1359135520000202.

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In this paper we establish a dialogue with Living with Buildings to contextualise NOTBAD (Niches for Organic Territories in Bio-Augmented Design), a multidisciplinary research project at the intersection of architecture and microbiology, sited within a wider historical discourse connecting architecture and health. Living with Buildings (2018) was organised by the Wellcome Trust to trace the changing landscape of health and architecture, setting out to show how connections between the ways we feel and the places in which we spend our lives have historically evolved as our ideas about health and

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Седов, Вл В. "The architecture of St. George's cathedral of Yuriev monastery and the first system of facades organisation in the Old Russian architecture: tiers of windows and arched niches." Architectural archeology, no. 4 (February 12, 2023): 5–48. http://dx.doi.org/10.25681/iaras.2022.978-5-94375-371-8.7-48.

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Статья посвящена особой архитектонической системе организации фасадов Георгиевского собора Юрьева монастыря: здесь помимо крупной аркады прясел есть еще ярусы окон и двухуступчатых арочных ниш, создающих регистры. Благодаря этому фасады становятся более организованными. Эта система попала в Новгород из Киева в самом начале XII в. и затем усложнялась, достигнув апогея в Георгиевском соборе. В Киев же она пришла из византийской архитектуры, где существуют два памятника середины - второй половины XI в., храмы в Велюсе и Учайяке, в которых ярусы ниш уже сложились в определенный порядок. В этих хра

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Heiland, P., J. A. Menstell, O. Schnell, J. Beck, J. Bremer, and D. Heiland. "P02.14.B SPATIAL TRANSCRIPTOMIC ARCHITECTURE OF TUMOURS OF THE PERIPHERAL NERVOUS SYSTEM." Neuro-Oncology 25, Supplement_2 (2023): ii32—ii33. http://dx.doi.org/10.1093/neuonc/noad137.099.

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Abstract BACKGROUND Studies into the genetics of peripheral nerve tumors have been focused on their association with known gene mutations and syndromes as well as on the tumor microenvironment of malignant peripheral nerve sheath tumors. Still, not many advances have been made into clarifying the structure and diverse pathophysiology of these tumors. Here we present spatially resolved transcriptomic profiling of benign and malignant entities and describe the topographical architecture of the neoplastic and microenvironmental diversity. MATERIAL AND METHODS We employed spatially resolved transc

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Suantika, I. Wayan. "IDENTIFIKASI BANGUNAN PADA PAHATAN TEBING DI SEPANJANG SUNGAI PAKERISAN, KABUPATEN GIANYAR." Forum Arkeologi 33, no. 1 (2020): 1. http://dx.doi.org/10.24832/fa.v33i1.520.

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Pakerisan River which located in Gianyar Regency is one of the famous rivers which has many archaeological sites. Some of them are rock-cut architectures, carved along its riverbank, such as Gunung Kawi Temple Site, Kerobokan Temple Site, Goa Garbha, and Tegallinggah Temple Site. In general, all of the rock-cut architectures are the depiction of buildings and could be categorized as sacred or profane in regard to their functions. These sites were built around 10th- 13th Century. This research aims to indentify all the building types based on the carving. Survey and interview were used in data

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Sánchez-Gomar, Ismael, Noelia Geribaldi-Doldán, Celeste Santos-Rosendo, et al. "Exploring the Intricacies of Neurogenic Niches: Unraveling the Anatomy and Neural Microenvironments." Biomolecules 14, no. 3 (2024): 335. http://dx.doi.org/10.3390/biom14030335.

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Neurogenesis is the process of forming new neurons from neural stem cells (NSCs). In adults, this process takes place in specific areas of the brain, known as neurogenic niches. These regions have unique anatomical features that have been studied in animal models and in the human brain; however, there are differences between these models that need to be addressed. The most studied areas are the subventricular zone, the lateral and latero-dorsal walls of the lateral ventricles, and the dentate gyrus of the hippocampus (Hp), which are known as the canonical areas. Other, less-studied niches, suc

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Kapustin, Petr. "The Bridge." проект байкал, no. 70 (December 17, 2021): 90–93. http://dx.doi.org/10.51461/projectbaikal.70.1895.

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The bridge is a popular image of formation of the city’s symbol, brand and composite character. The essay proposes interpretation of the mythopoetics of bridges, one of the most ambiguous, mysterious and attractive typological niches in architecture.

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Aguilar-Sanchez, Cristina, Melina Michael, and Sari Pennings. "Cardiac Stem Cells in the Postnatal Heart: Lessons from Development." Stem Cells International 2018 (June 24, 2018): 1–13. http://dx.doi.org/10.1155/2018/1247857.

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Heart development in mammals is followed by a postnatal decline in cell proliferation and cell renewal from stem cell populations. A better understanding of the developmental changes in cardiac microenvironments occurring during heart maturation will be informative regarding the loss of adult regenerative potential. We reevaluate the adult heart’s mitotic potential and the reported adult cardiac stem cell populations, as these are two topics of ongoing debate. The heart’s early capacity for cell proliferation driven by progenitors and reciprocal signalling is demonstrated throughout developmen

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Pérez, Maria del Carmen, Alejandro López, and Pablo Padilla. "Space-time dynamics of Stem Cell Niches: a unified approach for Plants." Journal of Integrative Bioinformatics 10, no. 2 (2013): 48–57. http://dx.doi.org/10.1515/jib-2013-219.

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Summary Many complex systems cannot be analyzed using traditional mathematical tools, due to their irreducible nature. This makes it necessary to develop models that can be implemented computationally to simulate their evolution. Examples of these models are cellular automata, evolutionary algorithms, complex networks, agent-based models, symbolic dynamics and dynamical systems techniques.We review some representative approaches to model the stem cell niche in Arabidopsis thaliana and the basic biological mechanisms that underlie its formation and maintenance. We propose a mathematical model b

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Meister, Chris. "Albert Kahn’s Partners in Industrial Architecture." Journal of the Society of Architectural Historians 72, no. 1 (2013): 78–95. http://dx.doi.org/10.1525/jsah.2013.72.1.78.

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The narrative of Albert Kahn’s rags-to-riches career, as previously told, suggests that his success was a matter of happenstance, augmented by a remarkable work ethic. The happenstance factor turns out to be a distortion resulting from the architect’s innate humility and a need to downplay his relationship with Joseph Boyer for business reasons. Although Boyer did not hire him in 1900 to design a machine shop as widely believed, the industrialist was nonetheless integral to the careers of Albert and Julius Kahn as the brothers developed their respective niches in industrial work. Having experi

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Fasnacht, Nicolas, Hsin-Ying Huang, Ute Koch, et al. "Specific fibroblastic niches in secondary lymphoid organs orchestrate distinct Notch-regulated immune responses." Journal of Experimental Medicine 211, no. 11 (2014): 2265–79. http://dx.doi.org/10.1084/jem.20132528.

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Fibroblast-like cells of secondary lymphoid organs (SLO) are important for tissue architecture. In addition, they regulate lymphocyte compartmentalization through the secretion of chemokines, and participate in the orchestration of appropriate cell–cell interactions required for adaptive immunity. Here, we provide data demonstrating the functional importance of SLO fibroblasts during Notch-mediated lineage specification and immune response. Genetic ablation of the Notch ligand Delta-like (DL)1 identified splenic fibroblasts rather than hematopoietic or endothelial cells as niche cells, allowin

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Kapetina, Mirna, Milan Rapaic, and Jelena Atanackovic-Jelicic. "An approach to optimal architectural and urban design from the energy efficiency point of view." Serbian Journal of Electrical Engineering 11, no. 1 (2014): 133–44. http://dx.doi.org/10.2298/sjee131129012k.

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This paper presents a new approach to architecture and urban design that results in an increase of the energy efficiency of buildings set close to each other, which is set as the optimization problem. The main goal is to maximize the sunlight impact on objects, in a way to minimize inter-object shading on each building. The problem is solved by the PSO (Particle Swarm Optimization) algorithm and its modifications, as well as the application of PSO algorithm with niches, which makes it possible to find a large number of local optima. It turned out that the PSO algorithm with niches is especiall

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Congrains, Ada, Juares Bianco, Renata G. Rosa, Rubia I. Mancuso, and Sara T. O. Saad. "3D Scaffolds to Model the Hematopoietic Stem Cell Niche: Applications and Perspectives." Materials 14, no. 3 (2021): 569. http://dx.doi.org/10.3390/ma14030569.

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Hematopoietic stem cells (HSC) are responsible for the production of blood and immune cells during life. HSC fate decisions are dependent on signals from specialized microenvironments in the bone marrow, termed niches. The HSC niche is a tridimensional environment that comprises cellular, chemical, and physical elements. Introductorily, we will revise the current knowledge of some relevant elements of the niche. Despite the importance of the niche in HSC function, most experimental approaches to study human HSCs use bidimensional models. Probably, this contributes to the failure in translating

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Moffet, Joel, Oluwaseun Fatunla, James Whittle, et al. "TMIC-36. SPATIAL ARCHITECTURE OF HIGH-GRADE GLIOMA REVEALS TUMOR HETEROGENEITY WITHIN DISTINCT DOMAINS." Neuro-Oncology 25, Supplement_5 (2023): v286. http://dx.doi.org/10.1093/neuonc/noad179.1102.

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Abstract High-grade gliomas are aggressive primary brain cancers with poor response to standard regimens, driven by immense heterogeneity. In isocitrate dehydrogenase (IDH) wild-type high-grade glioma (glioblastoma, GBM), increased intra-tumoral heterogeneity is associated with more aggressive disease. Recently, spatial technologies have emerged to dissect this complex heterogeneity within the tumor ecosystem by preserving cellular organization in situ. Here, we construct a high-resolution molecular landscape of GBM and IDH-mutant high-grade glioma patient samples to investigate the cellular s

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Shah, Nameeta, Hyun Jung Park, Pranali Sonpatki, et al. "TMIC-20. A SPATIALLY RESOLVED HUMAN GLIOBLASTOMA ATLAS REVEALS DISTINCT CELLULAR AND MOLECULAR PATTERNS OF ANATOMICAL NICHES." Neuro-Oncology 25, Supplement_5 (2023): v282. http://dx.doi.org/10.1093/neuonc/noad179.1086.

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Abstract Glioblastoma (GBM) is a highly plastic ecosystem where the complex interplay between different cellular components contributes to disease progression. Although single-cell RNA (scRNA)-seq has revealed remarkable cellular heterogeneity of GBM, our knowledge regarding the spatial organization of its cellular components is currently lacking. Here we created a comprehensive dataset of 115,914 spatial transcriptomes across 32 tissue sections with matched multi-omics profiling on a set of genotyped glioma samples. We present spatial maps of 56 fine-grained cellular components, including pre

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Potter, Mitchell A., and Kenneth A. De Jong. "Cooperative Coevolution: An Architecture for Evolving Coadapted Subcomponents." Evolutionary Computation 8, no. 1 (2000): 1–29. http://dx.doi.org/10.1162/106365600568086.

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To successfully apply evolutionary algorithms to the solution of increasingly complex problems, we must develop effective techniques for evolving solutions in the form of interacting coadapted subcomponents. One of the major difficulties is finding computational extensions to our current evolutionary paradigms that will enable such subcomponents to “emerge” rather than being hand designed. In this paper, we describe an architecture for evolving such subcomponents as a collection of cooperating species. Given a simple string- matching task, we show that evolutionary pressure to increase the ove

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de Janon, Alejandro, Athanasios Mantalaris, and Nicki Panoskaltsis. "Three-Dimensional Human Bone Marrow Organoids for the Study and Application of Normal and Abnormal Hematoimmunopoiesis." Journal of Immunology 210, no. 7 (2023): 895–904. http://dx.doi.org/10.4049/jimmunol.2200836.

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Abstract Hematoimmunopoiesis takes place in the adult human bone marrow (BM), which is composed of heterogeneous niches with complex architecture that enables tight regulation of homeostatic and stress responses. There is a paucity of representative culture systems that recapitulate the heterogeneous three-dimensional (3D) human BM microenvironment and that can endogenously produce soluble factors and extracellular matrix that deliver culture fidelity for the study of both normal and abnormal hematopoiesis. Native BM lymphoid populations are also poorly represented in current in vitro and in v

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Avancena, Patricia, Tengfei Song, Yonghong Yao, et al. "The magnitude of germinal center reactions is restricted by a fixed number of preexisting niches." Proceedings of the National Academy of Sciences 118, no. 30 (2021): e2100576118. http://dx.doi.org/10.1073/pnas.2100576118.

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Antibody affinity maturation occurs in the germinal center (GC), a highly dynamic structure that arises upon antigen stimulation and recedes after infection is resolved. While the magnitude of the GC reaction is highly fluctuating and depends on antigens or pathological conditions, it is unclear whether GCs are assembled ad hoc in different locations or in preexisting niches within B cell follicles. We show that follicular dendritic cells (FDCs), the essential cellular components of the GC architecture, form a predetermined number of clusters. The total number of FDC clusters is the same on se

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Caban, Mariusz. "The niches of the Vestibule of the Royal Mortuary Cult Complex of the Temple of Hatshepsut in Deir el-Bahari." Polish Archaeology in the Mediterranean XXIV, no. 2 (2016): 75–82. http://dx.doi.org/10.5604/01.3001.0010.0175.

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The article is about damages to the architecture and wall decoration of niches in the Vestibule of Hatshepsut in the Royal Mortuary Cult Complex. Traces of ancient repairs may be discerned in the distorted layers of limestone blocks and deformed relief. The nature of this restoration indicates that it took place once the sculpting of the reliefs had been completed but before the painting. The reasons for this can be related to the short building time of the temple.

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Lakshman, Nishanth, Clara Bourget, Ricky Siu, et al. "Niche-dependent inhibition of neural stem cell proliferation and oligodendrogenesis is mediated by the presence of myelin basic protein." Stem Cells 39, no. 6 (2021): 776–86. http://dx.doi.org/10.1002/stem.3344.

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Abstract Neural stem and progenitor cells (collectively termed neural precursor cells [NPCs]) are found along the ventricular neuraxis extending from the spinal cord to the forebrain in regionally distinct niches comprised of different cell types, architecture, and cell-cell interactions. An understanding of the factors that regulate NPC behavior is critical for developing therapeutics to repair the injured central nervous system. Herein, we demonstrate that myelin basic protein (MBP), the major cytoplasmic protein constituent of the myelin sheath in oligodendrocytes, can regulate NPC behavior

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Zhang, Yuanyuan, Fuduan Peng, Guangsheng Pei, Yunhe Liu, Guangchun Han, and Linghua Wang. "Abstract 4653: Spatial architecture of tumor-infiltrating macrophagesorchestrates tumor immunity and therapeutic response." Cancer Research 83, no. 7_Supplement (2023): 4653. http://dx.doi.org/10.1158/1538-7445.am2023-4653.

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Abstract Tumor-infiltrating macrophages, a major cellular component in the tumor microenvironment (TME), have been proven to be linked with tumor progression and immunotherapy resistance. Tremendous heterogeneity has been revealed for tumor-associated macrophages (TAMs) in different cancer types, however, how these TAM subtypes are localized and interact with tissue ecosystems remains poorly understood. Here, we perform an integrative analysis of TAMs, malignant and non-malignant cells from 10 cancer types, based on single-cell RNA-seq and spatial transcriptomic data. By interrogating the spat

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Costa-De los Reyes, Claudia, Silvia Viñán-Ludeña, María Isabel Vivanco-Villavicencio, and Fernando Moncayo-Serrano. "Tendencias de investigación en arquitectura entre 2016-2020 en la base de datos SCOPUS y su relación con la creación de grupos de investigación." Revista Hábitat Sustentable 11, no. 2 (2021): 46–59. http://dx.doi.org/10.22320/07190700.2021.11.02.04.

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The interest in making research more dynamic within universities has evidenced the need for the creation of research groups. In this sense, the purpose of this article is to establish a relationship between the data obtained from bibliometrics and the profile and interest of Architecture Faculty researchers, to identify research niches that guide their work. This research was carried out through a systematic review and use of scientific production bibliometric tools in the last five years within the architecture domain in the SCOPUS database. The research made used five steps that guided the p

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Guimarães, Paulo R. "The Structure of Ecological Networks Across Levels of Organization." Annual Review of Ecology, Evolution, and Systematics 51, no. 1 (2020): 433–60. http://dx.doi.org/10.1146/annurev-ecolsys-012220-120819.

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Interactions connect the units of ecological systems, forming networks. Individual-based networks characterize variation in niches among individuals within populations. These individual-based networks merge with each other, forming species-based networks and food webs that describe the architecture of ecological communities. Networks at broader spatiotemporal scales portray the structure of ecological interactions across landscapes and over macroevolutionary time. Here, I review the patterns observed in ecological networks across multiple levels of biological organization. A fundamental challe

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Chew, Shu Yih, Kok Lian Ho, Yoke Kqueen Cheah, Doblin Sandai, Alistair J. P. Brown, and Leslie Thian Lung Than. "Physiologically Relevant Alternative Carbon Sources Modulate Biofilm Formation, Cell Wall Architecture, and the Stress and Antifungal Resistance of Candida glabrata." International Journal of Molecular Sciences 20, no. 13 (2019): 3172. http://dx.doi.org/10.3390/ijms20133172.

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Flexibility in carbon metabolism is pivotal for the survival and propagation of many human fungal pathogens within host niches. Indeed, flexible carbon assimilation enhances pathogenicity and affects the immunogenicity of Candida albicans. Over the last decade, Candida glabrata has emerged as one of the most common and problematic causes of invasive candidiasis. Despite this, the links between carbon metabolism, fitness, and pathogenicity in C. glabrata are largely unexplored. Therefore, this study has investigated the impact of alternative carbon metabolism on the fitness and pathogenic attri

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Ene, Iuliana V., Shih-Chin Cheng, Mihai G. Netea, and Alistair J. P. Brown. "Growth of Candida albicans Cells on the Physiologically Relevant Carbon Source Lactate Affects Their Recognition and Phagocytosis by Immune Cells." Infection and Immunity 81, no. 1 (2012): 238–48. http://dx.doi.org/10.1128/iai.01092-12.

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Candida albicansis a normal resident of the human gastrointestinal and urogenital tracts and also a prevalent fungal pathogen. During both commensalism and infection, it must match the immunological defenses of its host while adapting to environmental cues and the local nutrient status.C. albicansregularly colonizes glucose-poor niches, thereby depending upon alternative carbon sources for growth. However, most studies of host immune responses toC. albicanshave been performed on fungal cells grown on glucose, and the extent to which alternative physiologically relevant carbon sources impact in

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Dickinson, Timothy A., Brigitte Xueqi Yan, Shery Han, and Mehdi Zarrei. "Niche Shifts, Hybridization, Polyploidy and Geographic Parthenogenesis in Western North American Hawthorns (Crataegus subg. Sanguineae, Rosaceae)." Agronomy 11, no. 11 (2021): 2133. http://dx.doi.org/10.3390/agronomy11112133.

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We compare biogeographic and morphological parameters of two agamic complexes of western North American hawthorns so as to evaluate possible explanations of the differences in range between sexually reproducing taxa and their apomictic sister taxa. We have documented range, breeding system, morphology, leaf vascular architecture, and niche breadth in these hawthorns, for which phylogenetic relationships and ploidy levels are known. Species distribution data from herbarium specimens and online databases were analyzed in order to compare ranges and climate niches described by bioclimatic variabl

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Zilivinskaya, Emma. "Bey Yude Sultan Türbe in Aziz: The History of Research, Architectural Form, Issues of Chronology." Materials in Archaeology, History and Ethnography of Tauria, XХVII (December 15, 2022): 441–66. http://dx.doi.org/10.29039/2413-189x.2022.27.441-466.

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This article studies the mausoleum of Bey Yude Sultan, located in Aziz, a suburb of Bakhchisarai. The account of the monument by various authors are cited, as well as some visual sources depicting the structure. The mausoleum is a cubic building. The cube passes into an octahedron via triangular bevels, which are called Turkish triangles by the historians of architecture. The octagon is covered with a spherical dome, which formerly was topped with a hip roof. On the south side, the building had a portal with typical Seljuk niches in the side walls. Above the door there is a building inscriptio

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Botquelen, Arnaud, Jean Le Menn, Rémy Gourvennec, and Alfredo Loi. "Crinoid columnal associations and sequence stratigraphy architecture: the Le Faou Formation, Lower Devonian of the Massif armoricain (France)." Bulletin de la Société Géologique de France 177, no. 1 (2006): 19–26. http://dx.doi.org/10.2113/177.1.19.

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Abstract Crinoid columnals are major macrobenthic components of the Lower Devonian faunas of the Massif armoricain particularly in the Seillou section. Three crinoid columnal associations have been delineated based on R and Q-mode cluster analysis. Distribution of these associations is correlated to the sequence stratigraphic architecture, showing the close relationships between crinoid columnal association dynamics and relative sea-level variations. Comparing the distribution of benthic associations, we note a lesser diversity in crinoid columnal associations than in brachiopod ones. Crinoids

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Clara-Trujillo, Sandra, Gloria Gallego Ferrer, and José Luis Gómez Ribelles. "In Vitro Modeling of Non-Solid Tumors: How Far Can Tissue Engineering Go?" International Journal of Molecular Sciences 21, no. 16 (2020): 5747. http://dx.doi.org/10.3390/ijms21165747.

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In hematological malignancies, leukemias or myelomas, malignant cells present bone marrow (BM) homing, in which the niche contributes to tumor development and drug resistance. BM architecture, cellular and molecular composition and interactions define differential microenvironments that govern cell fate under physiological and pathological conditions and serve as a reference for the native biological landscape to be replicated in engineered platforms attempting to reproduce blood cancer behavior. This review summarizes the different models used to efficiently reproduce certain aspects of BM in

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Rinkenbaugh, Amanda L., Vidya C. Sinha, Pankaj Singh, et al. "Abstract 1595: Analysis of spatiotemporal phenotypic heterogeneity in chemoresistant triple negative breast cancer using imaging mass cytometry." Cancer Research 82, no. 12_Supplement (2022): 1595. http://dx.doi.org/10.1158/1538-7445.am2022-1595.

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Abstract Shifts in tumor cell phenotype in response to selective pressures (i.e. changing microenvironments, drug treatments) pose one of the biggest obstacles to successful breast cancer therapies. Phenotypically diverse breast tumor and stroma subpopulations, and interactions between them that alter tumor cell biology, represent unique and spatially distinct niches. We hypothesize that localized neighborhoods of breast tumor cells possess specialized phenotypes that mediate chemoresistance and represent novel therapeutic vulnerabilities. In order to assess these potential phenotypes, we util

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Kastner, Fabian, and Silke Langenberg. "Transition in Architecture Education? Exploring Socio-Technical Factors of Curricular Changes for a Sustainable Built Environment." Sustainability 15, no. 22 (2023): 15949. http://dx.doi.org/10.3390/su152215949.

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Curricular changes in architecture can support to meet the increased demand for sustainability in higher education (HE). Identifying their associated factors is necessary to understand ongoing and future transitions in architecture education. Transition management (TM) frameworks have been frequently used to analyze structural changes in various institutions but have received little attention in architecture education. This study explores the Swiss Federal Institute of Technology (ETH Zurich) as a case study, focusing on its architecture curricula within 32 years from 1990 to 2022, correspondi

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Kowalski, Caitlin H., Kaesi A. Morelli, Daniel Schultz, Carey D. Nadell, and Robert A. Cramer. "Fungal biofilm architecture produces hypoxic microenvironments that drive antifungal resistance." Proceedings of the National Academy of Sciences 117, no. 36 (2020): 22473–83. http://dx.doi.org/10.1073/pnas.2003700117.

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Human fungal infections may fail to respond to contemporary antifungal therapies in vivo despite in vitro fungal isolate drug susceptibility. Such a discrepancy between in vitro antimicrobial susceptibility and in vivo treatment outcomes is partially explained by microbes adopting a drug-resistant biofilm mode of growth during infection. The filamentous fungal pathogenAspergillus fumigatusforms biofilms in vivo, and during biofilm growth it has reduced susceptibility to all three classes of contemporary antifungal drugs. Specific features of filamentous fungal biofilms that drive antifungal dr

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Ferreira de Lima, Thomas, Alexander N. Tait, Armin Mehrabian, et al. "Primer on silicon neuromorphic photonic processors: architecture and compiler." Nanophotonics 9, no. 13 (2020): 4055–73. http://dx.doi.org/10.1515/nanoph-2020-0172.

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AbstractMicroelectronic computers have encountered challenges in meeting all of today’s demands for information processing. Meeting these demands will require the development of unconventional computers employing alternative processing models and new device physics. Neural network models have come to dominate modern machine learning algorithms, and specialized electronic hardware has been developed to implement them more efficiently. A silicon photonic integration industry promises to bring manufacturing ecosystems normally reserved for microelectronics to photonics. Photonic devices have alre

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Cottignoli, Valentina, Michela Relucenti, Giovanna Agrosì, et al. "Biological Niches within Human Calcified Aortic Valves: Towards Understanding of the Pathological Biomineralization Process." BioMed Research International 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/542687.

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Despite recent advances, mineralization site, its microarchitecture, and composition in calcific heart valve remain poorly understood. A multiscale investigation, using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy dispersive X-ray spectrometry (EDS), from micrometre up to nanometre, was conducted on human severely calcified aortic and mitral valves, to provide new insights into calcification process. Our aim was to evaluate the spatial relationship existing between bioapatite crystals, their local growing microenvironment, and the presence of a hierarc

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Boulet, Nathalie, and Jean Galitzky. "La macro-architecture en lobules du tissu adipeux humain définit des niches influençant le devenir des cellules progénitrices." médecine/sciences 36, no. 3 (2020): 197–200. http://dx.doi.org/10.1051/medsci/2020039.

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Singh, Sharmila, Alka Singh, Archita Singh, et al. "Role of chromatin modification and remodeling in stem cell regulation and meristem maintenance in Arabidopsis." Journal of Experimental Botany 71, no. 3 (2019): 778–92. http://dx.doi.org/10.1093/jxb/erz459.

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Abstract In higher plants, pluripotent stem cells reside in the specialized microenvironment called stem cell niches (SCNs) harbored at the shoot apical meristem (SAM) and root apical meristem (RAM), which give rise to the aerial and underground parts of a plant, respectively. The model plant Arabidopsis thaliana (Arabidopsis) has been extensively studied to decipher the intricate regulatory mechanisms involving some key transcriptions factors and phytohormones that play pivotal roles in stem cell homeostasis, meristem maintenance, and organ formation. However, there is increasing evidence to

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Vanmechelen, Maxime, Jan Beckervordersandforth, Jon Pey, et al. "PATH-20. SPATIAL MAPPING OF THERAPY-INDUCED, PATHOLOGICAL CHANGES IN GLIOBLASTOMA AT SINGLE-CELL RESOLUTION." Neuro-Oncology 23, Supplement_6 (2021): vi119. http://dx.doi.org/10.1093/neuonc/noab196.472.

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Abstract Glioblastoma (GBM) remains a highly malignant, intrinsically resistant and inevitably recurring brain tumor with dismal prognosis. The aggressiveness and lack of effective GBM treatments can be attributed to the highly heterogeneous and plastic nature of GBM tumor cells, which easily confer resistance to standard-of-care (SOC) therapy. While tumor progression has also been attributed to interactions with the tumor microenvironment, quantitative data describing these interactions are still largely missing. Here, we used high-dimensional, multiplexed immunohistochemistry to map evolutio

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Oetjen, Karolyn A., Diane E. Bender, Marianna B. Ruzinova, Stephen T. Oh, and Daniel C. Link. "Interrogating the Spatial Architecture of Human Bone Marrow Via Imaging Mass Cytometry." Blood 134, Supplement_1 (2019): 3728. http://dx.doi.org/10.1182/blood-2019-127460.

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Hematopoietic stem cell (HSC) proliferation, self-renewal, differentiation, and trafficking are dependent, in part, upon signals generated by stromal cells in the bone marrow. Stromal cells are organized into niches that support specific subsets of hematopoietic progenitors. Intimate interactions between HSCs and neighboring stromal cells coordinate hematopoietic responses during periods of physiologic stress, while also maintaining the lifelong integrity of the hematopoietic stem cell pool. Hematopoietic niches are comprised of a heterogeneous population of stromal and hematopoietic cells. Th

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E.V., Kilimnik. "THE INTERNATIONAL FORM IN THE WORLD OF THE WORLD OF THE WEST EUROPE AND FORTIFICATION ART OF THE CRUSADERS IN THE MIDDLE EAST OF THE XIth AND XIIIth CENTURY." Global problems of modernity 1, no. 7 (2020): 4–16. http://dx.doi.org/10.26787/nydha-2713-2048-2020-1-7-4-16.

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The main purpose of the study is to conduct architectural and historical analysis of the formation of medieval feudal castles as a phenomenon of chivalrous culture of Europe and the Middle East. The task of the study is to analyze the general and special in the evolution of forms in the castle architecture of Western Europe and the Jerusalem medieval kingdom. Creation of architectural and historical typology of castle forms that existed in the regions of medieval Western Europe and the Levant. In the course of the analysis of the formation of Middle Eastern castle complexes of the 12th - 13th

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Di Martino, Julie S., Tasmiah Akhter, and Jose Javier Bravo-Cordero. "Remodeling the ECM: Implications for Metastasis and Tumor Dormancy." Cancers 13, no. 19 (2021): 4916. http://dx.doi.org/10.3390/cancers13194916.

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While most primary tumors can be effectively treated, therapeutics fail to efficiently eliminate metastases. Metastases arise from cancer cells that leave the primary tumor and seed distant sites. Recent studies have shown that cancer cells disseminate early during tumor progression and can remain dormant for years before they resume growth. In these metastatic organs, cancer cells reside in microenvironments where they interact with other cells, but also with the extracellular matrix (ECM). The ECM was long considered to be an inert, non-cellular component of tissues, providing their architec

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Lara, Pedro Jiménez. "ARQUEOLOGÍA DE SUPERFICIE EN TAJÍN." CLIO Arqueológica 34, no. 2 (2019): 57. http://dx.doi.org/10.20891/clio.v34n2p57-76.

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El sitio arqueológico de Tajín es considerado como el más importante de la Costa del Golfo, México, ubicada en una superficie de 144 hectáreas, emplazada en área de pequeñas colinas con cuencas abierta y cerradas, en una sucesión de plazas arquitectónicas edificada en plataformas semi-artificiales de manera estratificada. Edificios con terrazas soportadas por columnas cilíndricas, techos planos de gran envergadura y complejidad. Además de presentar una arquitectura sofisticada a base de lajas que dan forma a los nichos, grecas y cornisa volada, también contiene esculturas en piedra de volumen

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Stadlbauer, Andreas, Max Zimmermann, Arnd Doerfler, et al. "Intratumoral heterogeneity of oxygen metabolism and neovascularization uncovers 2 survival-relevant subgroups of IDH1 wild-type glioblastoma." Neuro-Oncology 20, no. 11 (2018): 1536–46. http://dx.doi.org/10.1093/neuonc/noy066.

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Abstract Background The intratumoral heterogeneity of oxygen metabolism in combination with variable patterns of neovascularization (NV) as well as reprogramming of energy metabolism affects the landscape of tumor microenvironments (TMEs) in glioblastoma. Knowledge of the hypoxic and perivascular niches within the TME is essential for understanding treatment failure. Methods Fifty-two patients with untreated glioblastoma (isocitrate dehydrogenase 1 wild type [IDH1wt]) were examined with a physiological MRI protocol including a multiparametric quantitative blood oxygen level dependent (qBOLD) a

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Ali, Mayar, Merel Kuijs, Soroor Hediyeh-zadeh, et al. "GraphCompass: spatial metrics for differential analyses of cell organization across conditions." Bioinformatics 40, Supplement_1 (2024): i548—i557. http://dx.doi.org/10.1093/bioinformatics/btae242.

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Abstract Summary Spatial omics technologies are increasingly leveraged to characterize how disease disrupts tissue organization and cellular niches. While multiple methods to analyze spatial variation within a sample have been published, statistical and computational approaches to compare cell spatial organization across samples or conditions are mostly lacking. We present GraphCompass, a comprehensive set of omics-adapted graph analysis methods to quantitatively evaluate and compare the spatial arrangement of cells in samples representing diverse biological conditions. GraphCompass builds upo

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Banach-Latapy, Agata, Vincent Rincheval, David Briand, Isabelle Guénal, and Pauline Spéder. "Differential adhesion during development establishes individual neural stem cell niches and shapes adult behaviour in Drosophila." PLOS Biology 21, no. 11 (2023): e3002352. http://dx.doi.org/10.1371/journal.pbio.3002352.

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Neural stem cells (NSCs) reside in a defined cellular microenvironment, the niche, which supports the generation and integration of newborn neurons. The mechanisms building a sophisticated niche structure around NSCs and their functional relevance for neurogenesis are yet to be understood. In the Drosophila larval brain, the cortex glia (CG) encase individual NSC lineages in membranous chambers, organising the stem cell population and newborn neurons into a stereotypic structure. We first found that CG wrap around lineage-related cells regardless of their identity, showing that lineage informa

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