Academic literature on the topic 'Nick'

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Journal articles on the topic "Nick"

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Zhang, Yinbo, Luther Davis, and Nancy Maizels. "Pathways and signatures of mutagenesis at targeted DNA nicks." PLOS Genetics 17, no. 4 (2021): e1009329. http://dx.doi.org/10.1371/journal.pgen.1009329.

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Nicks are the most frequent form of DNA damage and a potential source of mutagenesis in human cells. By deep sequencing, we have identified factors and pathways that promote and limit mutagenic repair at a targeted nick in human cells. Mutations were distributed asymmetrically around the nick site. BRCA2 inhibited all categories of mutational events, including indels, SNVs and HDR. DNA2 and RPA promoted resection. DNA2 inhibited 1 bp deletions but contributed to longer deletions, as did REV7. POLQ stimulated SNVs. Parallel analysis of DSBs targeted to the same site identified similar roles for DNA2 and POLQ (but not REV7) in promoting deletions and for POLQ in stimulating SNVs. Insertions were infrequent at nicks, and most were 1 bp in length, as at DSBs. The translesion polymerase REV1 stimulated +1 insertions at one nick site but not another, illustrating the potential importance of sequence context in determining the outcome of mutagenic repair. These results highlight the potential for nicks to promote mutagenesis, especially in BRCA-deficient cells, and identify mutagenic signatures of DNA2, REV1, REV3, REV7 and POLQ.
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Patkin, Eugene L., Maria E. Kustova, and Ekaterina M. Noniashvili. "DNA-strand breaks in chromosomes of early mouse embryos as detected by in situ nick translation and gap filling." Genome 38, no. 2 (1995): 381–84. http://dx.doi.org/10.1139/g95-049.

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The nick translation and gap filling procedures, without external addition of nicking enzymes, were performed in situ on fixed chromosomes of mouse preimplantation and postimplantation embryos and of bone marrow in order to detect possible DNA single-strand breaks (nicks and (or) gaps). All chromosome preparations were made using the same technique. Nick translation of chromosomal DNA with DNA polymerase I (Pol I) or gap filling with the Klenow fragment of Pol I in the presence of biotinylated-dUTP, demonstrated a regular absence of label on chromosomes of postimplantation embryos and bone marrow. No difference in sensitivity was found between the holoenzyme and the Klenow fragment. In preimplantation embryos, the chromosome reactivity in nick translation was highest at the blastocyst stage and varied according to cleavage divisions of the zygote.Key words: DNA-strand break, chromosomes of mouse embryos, in situ nick translation.
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ROSENFELD, NATANIA. "NICK." Yale Review 107, no. 1 (2019): 93. http://dx.doi.org/10.1353/tyr.2019.0009.

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ROSENFELD, NATANIA. "NICK." Yale Review 107, no. 1 (2018): 93. http://dx.doi.org/10.1111/yrev.13451.

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Karras, Anna. "Nick." Minnesota Review 2023, no. 101 (2023): 28–34. http://dx.doi.org/10.1215/00265667-10770156.

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Lee, Catherine A., and Alan D. Grossman. "Identification of the Origin of Transfer (oriT) and DNA Relaxase Required for Conjugation of the Integrative and Conjugative Element ICEBs1 of Bacillus subtilis." Journal of Bacteriology 189, no. 20 (2007): 7254–61. http://dx.doi.org/10.1128/jb.00932-07.

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ABSTRACT Integrative and conjugative elements (ICEs), also known as conjugative transposons, are mobile genetic elements that can transfer from one bacterial cell to another by conjugation. ICEBs1 is integrated into the trnS-leu2 gene of Bacillus subtilis and is regulated by the SOS response and the RapI-PhrI cell-cell peptide signaling system. When B. subtilis senses DNA damage or high concentrations of potential mating partners that lack the element, ICEBs1 excises from the chromosome and can transfer to recipients. Bacterial conjugation usually requires a DNA relaxase that nicks an origin of transfer (oriT) on the conjugative element and initiates the 5′-to-3′ transfer of one strand of the element into recipient cells. The ICEBs1 ydcR (nicK) gene product is homologous to the pT181 family of plasmid DNA relaxases. We found that transfer of ICEBs1 requires nicK and identified a cis-acting oriT that is also required for transfer. Expression of nicK leads to nicking of ICEBs1 between a GC-rich inverted repeat in oriT, and NicK was the only ICEBs1 gene product needed for nicking. NicK likely mediates conjugation of ICEBs1 by nicking at oriT and facilitating the translocation of a single strand of ICEBs1 DNA through a transmembrane conjugation pore.
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Davis, Luther, and Nancy Maizels. "Homology-directed repair of DNA nicks via pathways distinct from canonical double-strand break repair." Proceedings of the National Academy of Sciences 111, no. 10 (2014): E924—E932. http://dx.doi.org/10.1073/pnas.1400236111.

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DNA nicks are the most common form of DNA damage, and if unrepaired can give rise to genomic instability. In human cells, nicks are efficiently repaired via the single-strand break repair pathway, but relatively little is known about the fate of nicks not processed by that pathway. Here we show that homology-directed repair (HDR) at nicks occurs via a mechanism distinct from HDR at double-strand breaks (DSBs). HDR at nicks, but not DSBs, is associated with transcription and is eightfold more efficient at a nick on the transcribed strand than at a nick on the nontranscribed strand. HDR at nicks can proceed by a pathway dependent upon canonical HDR factors RAD51 and BRCA2; or by an efficient alternative pathway that uses either ssDNA or nicked dsDNA donors and that is strongly inhibited by RAD51 and BRCA2. Nicks generated by either I-AniI or the CRISPR/Cas9D10A nickase are repaired by the alternative HDR pathway with little accompanying mutagenic end-joining, so this pathway may be usefully applied to genome engineering. These results suggest that alternative HDR at nicks may be stimulated in physiological contexts in which canonical RAD51/BRCA2-dependent HDR is compromised or down-regulated, which occurs frequently in tumors.
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Pavani, Raphael, Veenu Tripathi, Dali Zong, et al. "Abstract IA016: Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms." Cancer Research 84, no. 1_Supplement (2024): IA016. http://dx.doi.org/10.1158/1538-7445.dnarepair24-ia016.

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Abstract Single strand breaks (SSBs), including DNA nicks, are the most common form of endogenous DNA damage. If they are not resolved before the passage of a replication fork, current models suggest that SSBs are converted to single-ended double strand breaks (seDSBs) and repaired by homologous recombination (HR). Here we show that when a replication fork encounters a Cas9-induced nick on the leading strand, the replisome is rapidly dislodged, and a highly resected seDSB is generated. In contrast, a Cas9-induced nick on the lagging strand rarely gives rise to a resected seDSB, either because Cas9 is actively evicted and the nick sealed prior to the arrival of the fork or because the nick is concealed as the replisome traverses the lesion, resulting in a double ended DSB (deDSB). Unlike canonical DSBs, end-resection at collapsed forks is BRCA1-independent. Instead, BRCA1 antagonizes 53BP1 to promote RAD51 filament formation and recombination. In the absence of strand invasion, exemplified by BRCA1-, RAD51-, and BRCA2- deficiencies, replication-coupled seDSBs are converted deDSBs by a converging fork. Together, our results demonstrate how nicks can give rise to DSBs in a strand asymmetrical manner, with implications for cancer-associated rearrangements and therapies that target the replication fork. Citation Format: Raphael Pavani, Veenu Tripathi, Dali Zong, Elsa Callen, Ajith Pankajam, Andre Nussenzweig, Wei Wu, Kyle Vrtis, Raj Chari, Johannes C Walter. Replication-coupled and canonical DNA double strand breaks are processed by distinct mechanisms [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: DNA Damage Repair: From Basic Science to Future Clinical Application; 2024 Jan 9-11; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2024;84(1 Suppl):Abstract nr IA016.
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Dekoven, Marianne. "Guest Column: Why Animals Now?" PMLA/Publications of the Modern Language Association of America 124, no. 2 (2009): 361–69. http://dx.doi.org/10.1632/pmla.2009.124.2.361.

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Myrtle Wilson, Tom Buchanan's working-class lover in F. Scott Fitzgerald's The Great Gatsby, wants “one of those police dogs” as an ornament “for the apartment,” because “they are nice to have” (27). Tom, Myrtle, and our narrator, Nick Carraway, have just arrived at Penn Station and gotten into a taxi, in the novel's second chapter. Myrtle boarded the train in Queens, site of her home in the Eliotic “valley of ashes,” joining Nick and Tom on the rail commute from their respective class-bound Long Island Eggs, upper East and nouveau West, into the city that is “built with a wish out of non-olfactory money” (69).
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Kavanagh, J. "Nick Donofrio." Computer Bulletin 43, no. 3 (2001): 16–17. http://dx.doi.org/10.1093/combul/43.3.16.

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Dissertations / Theses on the topic "Nick"

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Nick, Thomas [Verfasser]. "Stability of split-aptamers / Thomas Nick." Mainz : Universitätsbibliothek Mainz, 2017. http://d-nb.info/1122865783/34.

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Herrmann, Andrew F. "Bud and Nick: My Unofficial Mentors." Digital Commons @ East Tennessee State University, 2013. https://dc.etsu.edu/etsu-works/815.

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McGrath, Cole P. "Fighting tradition : Hemingway's Nick Adams and shell shock /." Connect to this title online, 2007. http://hdl.handle.net/1957/5525.

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Kloodt, Nick [Verfasser], and Natalie [Akademischer Betreuer] Neumeyer. "Nonparametric Transformation Models / Nick Kloodt ; Betreuer: Natalie Neumeyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://d-nb.info/1197801278/34.

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Kloodt, Nick Verfasser], and Natalie [Akademischer Betreuer] [Neumeyer. "Nonparametric Transformation Models / Nick Kloodt ; Betreuer: Natalie Neumeyer." Hamburg : Staats- und Universitätsbibliothek Hamburg, 2019. http://nbn-resolving.de/urn:nbn:de:gbv:18-100340.

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Nick, Fabian Pascal [Verfasser]. "Algebraic Multigrid for Meshfree Methods / Fabian Pascal Nick." Bonn : Universitäts- und Landesbibliothek Bonn, 2020. http://d-nb.info/1206417722/34.

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Nick, Theresa [Verfasser]. "Advanced Localization Concepts for RFID-based Systems / Theresa Nick." München : Verlag Dr. Hut, 2014. http://d-nb.info/1049363213/34.

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Nick, W. [Verfasser]. "Transienter Waermeuebergang an turbulent stroemendes ueberkritisches Helium / W. Nick." Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/119663226X/34.

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Nick, Eva-Maria [Verfasser]. "Mikrostruktur und mechanische Eigenschaften umgeschmolzener weichmartensitischer Stähle / Eva-Maria Nick." Aachen : Shaker, 2015. http://d-nb.info/1071527894/34.

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Nick, Bobo [Verfasser]. "Toward a Better Understanding of Evolving Social Networks / Bobo Nick." Konstanz : Bibliothek der Universität Konstanz, 2013. http://d-nb.info/1047063158/34.

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Books on the topic "Nick"

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Yates, Alma J. Nick. Deseret Book Company, 1995.

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Alm, Nick. Nick Alm. Arvinius+Orfeus, 2016.

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Nick. Call Nick. Lucky Baby Retreat House, 1985.

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Wendon, Lyn. Noisy Nick. Letterland Ltd., 1992.

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Strouse, Charles. Nick & Nora. CPP/Belwin, 1993.

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Cangioli, Andrea. Nick Cave. Stampa alternativa, 1995.

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Kassirer, Sue. Nick & Noel. Random House, 1993.

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Schmidt, Manfred. Nick Knatterton. Weltbild, 2005.

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Jennings, Elizabeth. Taming Nick. Kensington Pub. Corp., 2000.

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Humphries, Patrick. Nick Drake. Bloomsbury, 1998.

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Book chapters on the topic "Nick"

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Musleh-Motut, Nawal. "Nick." In Connecting the Holocaust and the Nakba Through Photograph-based Storytelling. Springer International Publishing, 2023. http://dx.doi.org/10.1007/978-3-031-27238-7_4.

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Leech, Beth L. "Nick Allard." In Lobbyists at Work. Apress, 2013. http://dx.doi.org/10.1007/978-1-4302-4561-2_3.

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Groß, Miriam. "Hornby, Nick." In Kindlers Literatur Lexikon (KLL). J.B. Metzler, 2020. http://dx.doi.org/10.1007/978-3-476-05728-0_8771-1.

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Buckland, David, and Chris Wainwright. "Nick Edwards." In Edition Angewandte. Springer Vienna, 2010. http://dx.doi.org/10.1007/978-3-7091-0221-3_12.

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Smith, Erin Copple. "Nick Jr." In From Networks to Netflix. Routledge, 2018. http://dx.doi.org/10.4324/9781315658643-18.

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Nünning, Vera. "Nick Hornby." In Kindler Kompakt Englische Literatur 20. Jahrhundert. J.B. Metzler, 2015. http://dx.doi.org/10.1007/978-3-476-05526-2_53.

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Gooch, Jan W. "Nick Translation." In Encyclopedic Dictionary of Polymers. Springer New York, 2011. http://dx.doi.org/10.1007/978-1-4419-6247-8_14319.

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Harp, Jerry. "In the Nick." In Why the Theatre. Routledge, 2020. http://dx.doi.org/10.4324/9781003017615-13.

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Hanzak, Elaine A., Diana Lynn Barnes, and Judith Ellis. "Nick and I." In Eyes Without Sparkle. Routledge, 2021. http://dx.doi.org/10.4324/9781846196621-2.

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Hashimoto, Satoshi, and Takashi Kanematsu. "In Situ Nick Translation." In Molecular Histochemical Techniques. Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-67915-8_2.

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Conference papers on the topic "Nick"

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Begeman, Michael, Peter Cook, Clarence Ellis, Mike Graf, Gail Rein, and Tom Smith. "Project Nick." In the 1986 ACM conference. ACM Press, 1986. http://dx.doi.org/10.1145/637069.637071.

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Wijana, I. Dewa Putu. "Javanese Nick Name System." In The 2nd International Conference of Linguistics and Culture (ICLC-2). Atlantis Press, 2022. http://dx.doi.org/10.2991/assehr.k.211225.006.

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Najafi, M. Hassan, Anirudh Murali, David J. Lilja, and John Sartori. "GPU-Accelerated Nick Local Image Thresholding Algorithm." In 2015 IEEE 21st International Conference on Parallel and Distributed Systems (ICPADS). IEEE, 2015. http://dx.doi.org/10.1109/icpads.2015.78.

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Gu, Jia. "Nick: An Unreliable Narrator in The Great Gatsby." In 2016 5th International Conference on Social Science, Education and Humanities Research. Atlantis Press, 2016. http://dx.doi.org/10.2991/ssehr-16.2016.162.

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"Keynote: Dr. Nick Bowen. Vice President of Technology, IBM." In 2010 23rd IEEE Conference on Software Engineering Education and Training. IEEE, 2010. http://dx.doi.org/10.1109/cseet.2010.9.

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Veni, George. "KARST, SCIENCE, AND LIFE: LESSONS FROM DR. NICK CRAWFORD." In GSA Annual Meeting in Seattle, Washington, USA - 2017. Geological Society of America, 2017. http://dx.doi.org/10.1130/abs/2017am-297224.

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Basin, David, Soren Debois, and Thomas T. Hildebrandt. "In the Nick of Time: Proactive Prevention of Obligation Violations." In 2016 IEEE 29th Computer Security Foundations Symposium (CSF). IEEE, 2016. http://dx.doi.org/10.1109/csf.2016.16.

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Zhong, Xiancai, Ha-Na Lee, and Young-Joon Surh. "Abstract 825: Myc-nick promotes efferocytosis through M2 macrophage polarization." In Proceedings: AACR 107th Annual Meeting 2016; April 16-20, 2016; New Orleans, LA. American Association for Cancer Research, 2016. http://dx.doi.org/10.1158/1538-7445.am2016-825.

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Stromeyer, C. F. "Facilitation of Red-Green Perception by Luminance Pedestals." In Color Appearance. Optica Publishing Group, 1987. http://dx.doi.org/10.1364/ca.1987.tua2.

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My colleagues (G.R. Cole, R.T. Eskew, Jr. and R.E. Kronauer) and I have been studying how luminance information may aid perception of red-green color changes. Related work has been done by Hilz et al, (1974), Boynton et al. (1977) and Nick and Larimer (1983).
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Baker, Nancy T. "NICK CRAWFORD’S INFLUENCE BEYOND KARST SCIENCE: CONTAMINANT TRANSPORT IN OTHER HYDROGEOLOGICAL SETTINGS." In GSA Annual Meeting in Seattle, Washington, USA - 2017. Geological Society of America, 2017. http://dx.doi.org/10.1130/abs/2017am-296992.

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Reports on the topic "Nick"

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Pridmore, Pat, Tristan McCowan, Roy Carr-Hill, et al. NICK End of Award Report. Institute of Education, University of London, 2014. http://dx.doi.org/10.35648/20.500.12413/11781/ii109.

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Orsi, N. Nick Orsi System Engineering Project - Shroud Flexure. Office of Scientific and Technical Information (OSTI), 2021. http://dx.doi.org/10.2172/1804292.

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Pridmore, Pat. Nutritional Improvement for children in urban Chile and Kenya (NICK). Institute of Education, University of London, 2012. http://dx.doi.org/10.35648/20.500.12413/11781/ii107.

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Gadd, M. G., J. M. Peter, and D. Layton-Matthews. Genesis of hyper-enriched black shale Ni-Mo-Zn-Pt-Pd-Re mineralization in the northern Canadian Cordillera. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/328013.

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Polymetallic (Ni-Mo-Zn-Pt-Pd-Au-Re) hyper-enriched black shales in the northern Canadian Cordillera consist of thin, semi-massive sulfides interbedded with black shale. We studied HEBS deposits at Nick, Peel River, Monster River, and Moss in northern Yukon, and at a single locality underlying the Cardiac Creek Pb-Zn-Ag deposit in northeastern British Columbia. High-grade mineralization contains up to 7.4 weight per cent Ni, 2.7 weight per cent Zn, 0.38 weight per cent Mo, 400 ppb Pt, 250 ppb Pd, 160 ppb Au, and 58.5 ppm Re. Sulfide mineralization formed during syngenesis to later diagenesis. Analyses by LA-ICP-MS indicate that pyrite is the principal host of platinum-group elements, Au, and Re. Mineralization and sedimentation were coeval based on the overlap between Re-Os geochronology of HEBS at Nick and Peel River (390.7 ± 5.1 and 387.3 ± 4.4 Ma, respectively) and conodont biostratigraphic ages of sedimentary host rocks. Bulk S isotope composition of HEBS is uniformly negative, indicating that bacterial reduction of seawater sulfate generated sulfur to precipitate sulfide minerals. The initial Os ratios at Peel River (0.25 ± 0.07) and Nick (0.32 ± 0.20) overlap with Middle Devonian seawater, suggesting that elemental enrichment was derived from seawater.
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Peter, J. M., M. G. Gadd, C. Jiang, and J. Reyes. Organic geochemistry and petrology of sedimentary exhalative Pb-Zn and polymetallic hyper-enriched black shale deposits in the Selwyn Basin, Yukon. Natural Resources Canada/CMSS/Information Management, 2022. http://dx.doi.org/10.4095/328017.

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Paleozoic strata of the Selwyn Basin host sedimentary exhalative (SEDEX) Pb-Zn deposits, and age-correlative strata of the Richardson trough host polymetallic hyper-enriched black shale (HEBS) deposits. In both deposit types, organic matter is spatially and temporally associated with mineralization. We investigated the characteristics of organic matter in mineralization and unmineralized host rocks in the XY Central SEDEX deposit in the Howard's Pass district, and the Nick and Peel River HEBS deposits in the Richardson trough using Rock-Eval pyrolysis, organic petrography, and solvent extraction and gas chromatography mass spectrometry (GCMS) analysis of the soluble organic matter (SOM). All samples experienced extremely high thermal maturity (Tmax up to 599°C), indicating they contain low SOM. Rock-Eval parameters S1, S2, HI, and OI values are low. Total organic carbon (TOC) values are low for Nick and Peel River and are generally higher for XY Central. Residual carbon values are universally high. Mineral carbon values are low for deposits studied (one outlier). Pyrobitumen reflectance is mostly below 5.80%. Full-scan GCMS analyses of SOM reveal that most, if not all, high molecular weight hydrocarbons, including biomarkers, have been lost due to thermal cracking and many detected peaks are likely due to contaminants introduced during sampling.
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Wetzel, Karen. NICE Framework Competency Areas:. National Institute of Standards and Technology, 2023. http://dx.doi.org/10.6028/nist.ir.8355.

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Wang, He, Jun Chen, Xiaoling Wang, and Jun Dang. Neoadjuvant immune checkpoint inhibitor in combination with chemotherapy or chemoradiotherapy in resectable esophageal cancer: A systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0052.

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Review question / Objective: It remains unclear whether addition of immune checkpoint inhibitor (ICI) to neoadjuvant chemoradiotherapy (nCRT) or neoadjuvant chemotherapy (nCT) can increase antitumor efficacy in resectable esophageal cancer (EC). we performed the systematic review and meta-analysis to assess antitumor efficacy and safety of nICRT and nICT, and made a comparison with nCRT and nICT. We used pathological complete response (pCR) as the primary outcomes of interest. Condition being studied: Initial findings from a number of phase 1 or 2 trials have supported the tolerability and/or antitumor efficacy of ICI plus nICRT (nICRT) and nICT (nICT). However, the superiority of this combination strategy remains uncertain due to lack of randomized control trials (RCTs) with long-term outcomes. Moreover, there are still outstanding questions such as the selection of nICRT or nICT, the ideal predictive biomarkers, and timing of surgical resection.
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Petersen, Rodney, Danielle Santos, Matthew C. Smith, Karen A. Wetzel, and Greg Witte. Workforce Framework for Cybersecurity (NICE Framework). National Institute of Standards and Technology, 2020. http://dx.doi.org/10.6028/nist.sp.800-181r1.

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This publication from the National Initiative for Cybersecurity Education (NICE) describes the Workforce Framework for Cybersecurity (NICE Framework), a fundamental reference for describing and sharing information about cybersecurity work. It expresses that work as Task statements and describes Knowledge and Skill statements that provide a foundation for learners including students, job seekers, and employees. The use of these statements helps students to develop skills, job seekers to demonstrate competencies, and employees to accomplish tasks. As a common, consistent lexicon that categorizes and describes cybersecurity work, the NICE Framework improves communication about how to identify, recruit, develop, and retain cybersecurity talent. The NICE Framework is a reference source from which organizations or sectors can develop additional publications or tools that meet their needs to define or provide guidance on different aspects of cybersecurity education, training, and workforce development.
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Karamati, Sara, Jeffrey Young, Tom Conte, et al. Computational Offload With BlueField Smart NICs. Office of Scientific and Technical Information (OSTI), 2021. http://dx.doi.org/10.2172/1832297.

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Williamson, S., and L. Nobile. Transition of Nic Services. RFC Editor, 1991. http://dx.doi.org/10.17487/rfc1261.

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