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Journal articles on the topic 'Nicklaus'

Author: Grafiati
Published: 4 June 2021
Last updated: 31 July 2024

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1

Swift, J. "Attlee: a Life in Politics, by Nicklaus Thomas-Symonds." English Historical Review CXXVII, no. 526 (April 17, 2012): 770–72. http://dx.doi.org/10.1093/ehr/ces068.

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2

Seaton, Andrew. "Nicklaus Thomas-Symonds,Nye: The Political Life of Aneurin Bevan." Social History of Medicine 28, no. 4 (June 24, 2015): 928–29. http://dx.doi.org/10.1093/shm/hkv050.

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3

贾, 忱. "The Comment of Beijing Reignwood Nicklaus Golf Course’s Design of Landscapes." Advances in Physical Sciences 06, no. 03 (2018): 101–7. http://dx.doi.org/10.12677/aps.2018.63018.

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4

Klobas, Mark. "Book Review: Nicklaus Thomas-Symonds, Nye: The Political Life of Aneurin Bevan." Political Studies Review 14, no. 3 (July 8, 2016): 472–73. http://dx.doi.org/10.1177/1478929916645702.

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5

Enghelberg, Moises, Alice Wong, Zenia P. Aguilera, and Roberto Warman. "Retrospective Review of Pediatric Thyroid Eye Disease Cases Referred to Nicklaus Children's Hospital." Vision Pan-America, The Pan-American Journal of Ophthalmology 17, no. 3 (October 3, 2018): 54–58. http://dx.doi.org/10.15234/vpa.v17i3.478.

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Purpose: We evaluate presenting features of pediatric thyroid eye disease, and discuss the morbidity and clinical course of this condition in the pediatric population. Methods: A retrospective chart review of 11 patients referred for evaluation of thyroid eye disease at a pediatric tertiary care facility in Miami, Florida.Results: The average age at presentation was 12.7 years. The most common ocular complaint was mild irritation. Patients tended to be positive for thyroid stimulating immunoglobulin and thyroid peroxidase antibody. The average displacement on Hertel exophthalmometry was 21mm for the right eye, and 21.45mm for the left eye. Lower scleral show was the most common eyelid finding. Conclusion: In contrast to thyroid eye disease in adults, the condition tends to present with mild ocular findings in children. Pediatric patients presenting with thyroid eye disease respond very well to medical therapy aimed at enhancing the altered ocular surface.
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6

Gaski, John F. "For Sport Journalists to Count and Report Major Championships in Golf: Per Coherent Definition and Conventional Classification, Nicklaus Has 20 Majors." International Journal of Sport Communication 14, no. 1 (March 1, 2021): 1–10. http://dx.doi.org/10.1123/ijsc.2020-0313.

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Over the past 3 decades or so, some variation and revision have been introduced into the recording, reporting, and interpretation of the prime historical benchmark of individual golf achievement: number of established major tournaments won. In the interest of accuracy, consistency, and even equity, some analytic record-keeping suggestions are proffered here, based on coherence and logic, toward presenting the history of golf’s major championships in the fairest possible way. Idiosyncrasies of that historical sequence mean that the resolution is not obvious and more taxonomic work remains to be done. However, acceptance of the principles and conventions proposed herein may move the golf history culture and even basic golf chronicling closer to advantageous closure. One competitive implication of this reanalysis applies, significantly, to the total of “majors” won by historical greats Jack Nicklaus, Bobby Jones, and Tiger Woods.
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7

Gonzalez, Jackie, Deborah Hill-Rodriguez, Laura M. Hernandez, Jessica R. Williams, and Jennifer A. Cordo. "The Nicklaus Children's Hospital Humpty Dumpty Falls Prevention Program™: Preventing Falls in Children Across the Globe." Nurse Leader 14, no. 3 (June 2016): 212–18. http://dx.doi.org/10.1016/j.mnl.2015.12.005.

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8

Weiler, Peter. "Attlee: A Life in Politics. By Nicklaus Thomas-Symonds. London: I. B. Tauris, 2010. Pp. xiv+329. £25.00." Journal of Modern History 84, no. 1 (March 2012): 187–88. http://dx.doi.org/10.1086/663123.

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9

Corthorn, Paul. "Nicklaus Thomas-Symonds. Attlee: A Life in Politics. London: I. B. Tauris, 2010. Pp. xiii+329. £25.00 (cloth)." Journal of British Studies 50, no. 3 (July 2011): 778–80. http://dx.doi.org/10.1086/659815.

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10

Wang, S., S. Stone, AG Weil, A. Fallah, BC Warf, J. Ragheb, S. Bhatia, and AV Kulkarni. "P.027 Comparative effectiveness of flexible vs. rigid neuroendoscopy for ETV/CPC: a propensity score matched cohort and survival analysis." Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 44, S2 (June 2017): S20. http://dx.doi.org/10.1017/cjn.2017.112.

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Background: ETV/CPC has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid neuroendoscopy can be used, with little empirical evidence directly comparing the two. We, therefore, used a propensity-matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid neuroendoscopy. Methods: Individual data were collected through retrospective review of infants < 2 years of age, treated at one of 2 hospitals: 1) Boston Children’s Hospital, exclusively utilizing flexible neuroendoscopy, and 2) Nicklaus Children’s Hospital, exclusively utilizing rigid neuroendoscopy. Patient characteristics and post-operative outcome were assessed. A propensity score (PS) model was developed to balance patient characteristics in the case mix. Results: A PS model was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. PS analysis revealed that compared to flexible neuroendoscopy, rigid neuroendoscopy had an ETV/CPC failure OR of 1.43 and 1.31 respectively, compared to unadjusted OR of 2.40. Furthermore, in a Cox regression analysis controlled by propensity score, rigid neuroendoscopy had a HR of 1.10, compared to unadjusted HR of 1.61. Conclusions: Much of the difference in ETV/CPC outcome between endoscopy types is attributed to the case mix. An observational study or randomized controlled trial is required to provide evidence-based guidelines.
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Wang, Shelly, Scellig Stone, Alexander G. Weil, Aria Fallah, Benjamin C. Warf, John Ragheb, Sanjiv Bhatia, and Abhaya V. Kulkarni. "Comparative effectiveness of flexible versus rigid neuroendoscopy for endoscopic third ventriculostomy and choroid plexus cauterization: a propensity score–matched cohort and survival analysis." Journal of Neurosurgery: Pediatrics 19, no. 5 (May 2017): 585–91. http://dx.doi.org/10.3171/2016.12.peds16443.

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OBJECTIVEEndoscopic third ventriculostomy (ETV)/choroid plexus cauterization (CPC) has become an increasingly common technique for the treatment of infant hydrocephalus. Both flexible and rigid neuroendoscopy can be used, with little empirical evidence directly comparing the two. Therefore, the authors used a propensity score–matched cohort and survival analysis to assess the comparative efficacy of flexible and rigid neuroendoscopy.METHODSIndividual data were collected through retrospective review of infants younger than 2 years of age, treated at 1 of 2 hospitals: 1) Boston Children's Hospital, exclusively utilizing flexible neuroendoscopy, and 2) Nicklaus Children's Hospital-Jackson Memorial Hospital, exclusively utilizing rigid neuroendoscopy. Patient characteristics and postoperative outcomes were assessed. A propensity score model was developed to balance patient characteristics in the case mix.RESULTSA propensity score model for neuroendoscope type was developed with 5 independent variables: chronological age, sex, hydrocephalus etiology, prior CSF diversion, and prepontine scarring. Propensity score decile-adjusted and 1-to-1 nearest-neighbor matching analysis revealed that compared with flexible neuroendoscopy, rigid neuroendoscopy had an ETV/CPC failure odds ratio (OR) of 1.43 (p = 0.31) and 1.31 (p = 0.47), respectively, compared with an unadjusted OR of 2.40 (p = 0.034). Furthermore, in a Cox regression analysis controlled by propensity score, rigid neuroendoscopy had a hazard ratio (HR) of 1.10 (p = 0.70), compared with an unadjusted HR of 1.61 (p = 0.031).CONCLUSIONSAlthough unadjusted analysis suggested worse ETV/CPC outcomes for infants treated by rigid neuroendoscopy, much of the difference could be attributed to the case mix and other predictors of outcome. A larger sample observational study or randomized controlled trials are required to provide evidence-based guidelines on ETV/CPC technique.
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12

Ye, Vincent C., Ashish H. Shah, Samir Sur, Justin K. Achua, Shelly Wang, George M. Ibrahim, Sanjiv Bhatia, and John Ragheb. "Long-term outcomes after surgery for catastrophic epilepsy in infants: institutional experience and review of the literature." Journal of Neurosurgery: Pediatrics 26, no. 2 (August 2020): 157–64. http://dx.doi.org/10.3171/2020.1.peds19537.

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OBJECTIVEUncontrolled epilepsy is associated with serious deleterious effects on the neurological development of infants and has been described as “catastrophic epilepsy.” Recently, there has been increased emphasis on early surgical interventions to preserve or rescue neurodevelopmental outcomes in infants with early intractable epilepsy. The enthusiasm for early treatments is often tempered by concerns regarding the morbidity of neurosurgical procedures in very young patients. Here, the authors report outcomes following the surgical management of infants (younger than 1 year).METHODSThe authors performed a retrospective review of patients younger than 1 year of age who underwent surgery for epilepsy at Miami (Nicklaus) Children’s Hospital and Jackson Memorial Hospital between 1994 and 2018. Patient demographics, including the type of interventions, were recorded. Seizure outcomes (at last follow-up and at 1 year postoperatively) as well as complications are reported.RESULTSThirty-eight infants (median age 5.9 months) underwent a spectrum of surgical interventions, including hemispherectomy (n = 17), focal resection (n = 13), and multilobe resections (n = 8), with a mean follow-up duration of 9.1 years. Hemimegalencephaly and cortical dysplasia were the most commonly encountered pathologies. Surgery for catastrophic epilepsy resulted in complete resolution of seizures in 68% (n = 26) of patients, and 76% (n = 29) had a greater than 90% reduction in seizure frequency. Overall mortality and morbidity were 0% and 10%, respectively. The latter included infections (n = 2), infarct (n = 1), and immediate reoperation for seizures (n = 1).CONCLUSIONSSurgical intervention for catastrophic epilepsy in infants remains safe, efficacious, and durable. The authors’ work provides the longest follow-up of such a series on infants to date and compares favorably with previously published series.
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13

Fraustro, Milena, Breyonna Maddox, Lilibet Fernandez Valdes, Elizabeth Lopez, Toba Niazi, Ossama Maher, and Ziad Khatib. "ATRT-18. ALISERTIB USED IN PEDIATRIC ATRT." Neuro-Oncology 26, Supplement_4 (June 18, 2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.018.

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Abstract BACKGROUND Atypical rhabdoid tumor (ATRT) is a rare and aggressive primary CNS tumor caused by variants or deletions in the tumor suppressor gene SMARCB1 (aka INI 1). SMARCB1 targets Aurora A kinase (AURKA), an important oncoprotein of the cell cycle. AURKA dysregulation can lead to genomic instability through its oncogenic effects. Alisertib is a selective AURKA inhibitor that has been explored for treatment in various cancers, including pediatric malignancies. METHODS Retrospective chart review of five patients diagnosed with ATRT, treated with Alisertib, at Nicklaus Children’s Hospital from 2019 - 2024. RESULTS of the 5 patients; three were females and two males, with a median age at diagnosis of 2 years. Only one patient had a germline mutation while the rest had somatic mutations. Prior to starting Alisertib therapy, all five patients received chemotherapy per multiple protocols; four patients underwent focal radiation therapy, three patients underwent resection, and two patients underwent tandem autologous transplants. All five patients were treated solely with Alisertib, median dose of 60 mg/m2 PO daily. Two patients had reduced doses during therapy secondary to cytopenia. One patient completed therapy over 13 months with partial response based on imaging. One patient presented progression of disease while on therapy and for that reason treatment was stopped. Three patients continue treatment: two with only Alisertib, one using Avastin and Sirolimus concurrently. CONCLUSIONS Prognosis in patients with ATRT is usually poor given its aggressive nature and high rate of recurrence despite intervention. It is important to note that treatment of ATRT is highly individualized and typically involves a combination of therapeutic modalities. While Alisertib is one of the newest treatment options, there’s limited literature of clinical improvement in patients with ATRT using this treatment. Therefore, further research on novel treatment options is warranted for the future.
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14

Maher, Ossama, Toba Niazi, Ziad Khatib, and John Ragheb. "RARE-31. TREATMENT OUTCOME OF CHILDREN WITH PLEOMORPHIC XANTHOASTROCYTOMA: RETROSPECTIVE ANALYSIS – A SINGLE INSTITUTION EXPERIENCE." Neuro-Oncology 21, Supplement_6 (November 2019): vi228. http://dx.doi.org/10.1093/neuonc/noz175.954.

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Abstract BACKGROUND Pleomorphic xanthoastrocytoma (PXA) and anaplastic pleomorphic xanthoastrocytoma (APXA) are two types of rare astrocytomas in pediatrics. There is limited literature reporting their outcomes. METHODS A retrospective analysis of pediatric patients with diagnosis of PXA and APXA treated at Nicklaus Children’s Hospital was conducted using descriptive measures. RESULTS A chart review of patients with brain tumors from 2001 to 2019 revealed that 13 patients (median age 6 years, range 2–17 years) were diagnosed with non-metastatic PXA (n=12) and APXA (n=1). Six patients (46%) were male. Clinical presentation included seizures (n=8), headaches (n=2) cranial nerve palsies (n=2). Diagnostic imaging showed tumor in the temporal lobe (n=5), parietal lobe (n=2), temporoparietal lobe (n=2), frontal lobe (n=1), occipital lobe (n=1), others (n=2). BRAF V600E mutation were identified in three of five analyzed tumors including PXA (n=4) and APXA (n=1). Surgical intervention consisted of gross total resection (n=8) and near/subtotal resection (n=5). Ten patients (76%) required a second surgery (median 2; range 1–4) due to local recurrence. The median time to recurrence was 3 years (range 6 months - 7 years). Three patients (23%) had malignant transformation of PXA, which occurred three to eight years from the initial surgery; one of them also had extensive spinal metastasis. Focal radiation was given to six patients (46%) due to multiple recurrence (n=2), malignant transformation (n=3), APXA (n=1). At a median follow up of 8 years (range 3 to 20 years), eight patients remain alive, three patients had lost to follow up, two patients died from progressive disease. Long-term sequelae varied as follows; seizures (n=5), motor weakness (n=4), cranial nerve palsies (n=2), and learning disability (n=1). CONCLUSION PXA is associated with high local recurrence rate and uncommonly malignant transformation to APXA in pediatrics, which requires close follow-up due to unpredictable biological behavior of these tumors.
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15

Fraustro, Milena, Breyonna Maddox, Lilibet Fernandez Valdes, Elizabeth Lopez, Toba Niazi, Ossama Maher, and Ziad Khatib. "LGG-54. PEDIATRIC LOW-GRADE GLIOMAS TREATED WITH MEK INHIBITORS." Neuro-Oncology 26, Supplement_4 (June 18, 2024): 0. http://dx.doi.org/10.1093/neuonc/noae064.444.

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Abstract BACKGROUND Low-grade gliomas (LGG) represent the most common brain tumor in children. It is well known that these tumors present mutations involving the BRAF gene, causing activation of the MAPK/ERK pathway. MEK inhibitors have now become an important treatment option over the recent years, slowing the growth of cancer cells. METHODS Retrospective analysis of 23 patients with LGG that were treated with MEK inhibitors at Nicklaus Children’s Hospital between 2015-2022. RESULTS Of the 23 patients; 6 were males and 17 were females, with a median age at diagnosis of 9.5 years of age. BRAF V600E mutation was present in 52% of patients (9/17). Other mutations found were: BRAF, BRAF KIAA1549, p.Q61K, and FGFR. Six patients had known associations with NF1. 7 of 23 patients had not received any prior treatment before MEK therapy, 8 underwent partial or total resection only prior, 4 had previous chemotherapy treatment, 3 underwent resection with chemotherapy, and 1 patient had both chemotherapy and proton radiation prior to MEK therapy. Targeted therapies included Trametinib (17/23), Dabrafenib (9/23), Selumetinib (5/23), and Binimetinib (1/23). Of the 9 patients with BRAF V600E mutation, 7/9 were given dual targeted therapies whereas only two were treated with only one inhibitor. The average length of therapy was one year. Most reported side effects were dermatologic manifestations such as dry skin or acne (9/23). Five patients showed objective improvement, 16 patients had stable residual disease, one had local recurrence, and one patient expired. Currently 12 patients are off therapy and 10 remain on treatment. Of the patients with BRAF V600E mutation, 4 had clinical and/or radiologic response, 1 patient expired due to disease progression and 1 has stable disease. CONCLUSION MEK inhibitors as a treatment of pediatric low-grade gliomas demonstrated promise as a therapeutic approach, so far proving to slow progression of disease in some cases. However, long-term side effects and toxicity remain unknown. Further large-scale prospective analysis would be helpful in future studies.
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16

Sedwick, Caitlin. "Bruce Nicklas: Pioneering studies on spindle forces." Journal of Cell Biology 198, no. 4 (August 20, 2012): 474–75. http://dx.doi.org/10.1083/jcb.1984pi.

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17

Назарчук, Александр. "Nicklas Luhman’s Theoretico-Political Views." Полис. Политические исследования, no. 3 (2006): 136–49. http://dx.doi.org/10.17976/jpps/2006.03.11.

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18

Hamon, Philippe. "Jean Balsamo, Thomas Nicklas, Bruno." Revue de l'histoire des religions, no. 235 (September 1, 2018): 566–69. http://dx.doi.org/10.4000/rhr.9152.

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19

Luther, Susanne. "Buchreport." Zeitschrift für Neues Testament 26, no. 51 (September 4, 2023): 131–38. http://dx.doi.org/10.24053/znt-2023-0009.

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Rezension: Stefan Alkier, Christos Karakolis und Tobias Nicklas: Sola Scriptura ökomenisch – Leiden: Brill, 2021 (Biblische Argumente in öffentlichen Debatten 1) – XIX. 235 S. ISBN: 978-3-506-76038-8 eISBN: 978-3-657-76038-1
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Acanda de la Rocha, Arlet Maria, Maggie Fader, Ebony Coats, Joseph Dunn, Leat Perez, Cima Saghira, Ileana Sotto, et al. "Abstract 4103: Feasibility and efficacy of a functional precision medicine approach in the management of relapsed/refractory childhood cancers." Cancer Research 82, no. 12_Supplement (June 15, 2022): 4103. http://dx.doi.org/10.1158/1538-7445.am2022-4103.

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Abstract Pediatric cancers are fundamentally different from those in adults, with lower frequency of genetic mutations and fewer options for targeted therapies. The implementation of functional precision medicine (FPM) - the integration of ex vivo drug screening and mutation profiling- can, therefore, provide better treatment options for pediatric tumor patients. In this study, we investigated the feasibility and clinical utility of FPM in the management of pediatric patients with recurrent and/or refractory cancers. We use a functional ex vivo drug screening test (DST) panel encompassed 40 formulary drugs frequently used at Nicklaus Children’s hospital and 47 non-formulary drugs approved by FDA for cancer treatment, as well as drugs from phase III and IV clinical trials. Drug sensitivity scores (DSS) were calculated for each drug based on cancer cells’ responses. DST results were then combined with results from targeted mutation profiles to match actionable mutations with selective targeted therapies. We have recruited a total of 21 patients into this ongoing clinical trial (number NCT03860376) and were able to perform drug testing and mutation profiling on 17 patients. We optimized and successfully performed DST on at least 13 different tumor types including acute myeloid leukemia, chronic lymphoblastic leukemia, ependymoma, osteosarcoma, Ewing’s sarcoma, rhabdomyosarcoma, glioblastoma, medulloblastoma, astrocytoma, neuroblastoma, rhabdoid, lung, and liver tumors. Our feasibility study, so far, has demonstrated that ex vivo DST can be performed within a clinically actionable time frame (median: 7 days). Ex vivo DST returned between 10 and 30 treatment options for each patient. These patients showed different responses to the 103 FDA-approved compounds used in the screen. More than half of the evaluated compounds were not active in any of the patients. Remarkably, DST provided valuable information to the oncologists on drug dosing and treatments that may not be effective and should be avoided. DSS synergizes with genomic data to further refine treatment recommendations. FPM-guided treatment regimens resulted in encouraging partial and complete responses as compared to progressive disease in prior regimens and physician choice regimens. Thus, our study shows technical feasibility of integrating functional precision medicine approaches for patients with refractory/relapsed pediatric cancers. Routine clinical integration of FPM for treatment selection is technically feasible and has led to improved treatment of pediatric cancer patients with refractory malignancies in an initial patient cohort, warranting further investigation. Citation Format: Arlet Maria Acanda de la Rocha, Maggie Fader, Ebony Coats, Joseph Dunn, Leat Perez, Cima Saghira, Ileana Sotto, Ziad Khatib, Ossama Maher, Haneen Abdella, Cristina M. Andrade-Feraud, Alexa Jacome, Lilliam Rimblas, Paula S. Espinal, Tomás R. Guilarte, Jennifer McCafferty-Fernandez, Daria Salyakina, Diana J. Azzam. Feasibility and efficacy of a functional precision medicine approach in the management of relapsed/refractory childhood cancers [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 4103.
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Karrer, Martin. "Der zweite Thessalonicherbrief, written by Tobias Nicklas." Biblische Zeitschrift 65, no. 1 (January 20, 2021): 157–58. http://dx.doi.org/10.30965/25890468-06402009-01.

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22

Kreindler, Michael S. "In re: Nicklas (JACI 1990;85:959–964)." Journal of Allergy and Clinical Immunology 88, no. 3 (September 1991): 422. http://dx.doi.org/10.1016/0091-6749(91)90110-a.

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Laster, Leonard. "Nickles and Dimes." Hospital Practice 33, no. 2 (February 15, 1998): 67–69. http://dx.doi.org/10.1080/21548331.1998.11443634.

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24

Rohde, Katrin. "Nachgefragt bei Prof. Dr. med. Jeanne Nicklas-Faust." JuKiP - Ihr Fachmagazin für Gesundheits- und Kinderkrankenpflege 02, no. 02 (April 4, 2013): 77. http://dx.doi.org/10.1055/s-0033-1341651.

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de la Rocha, Arlet Maria Acanda, Maggie Fader, Ebony R. Coats, Joseph Dunn, Leat Perez, Carolina Velasquez, Jeanette Galano, et al. "Abstract LB358: Efficacy of a functional precision medicine approach in relapsed/refractory pediatric cancer patients: results from a prospective clinical study." Cancer Research 83, no. 8_Supplement (April 14, 2023): LB358. http://dx.doi.org/10.1158/1538-7445.am2023-lb358.

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Abstract Personalized medicine often serves as the first salvage therapy strategy when standard oncology treatments fail. However, most precision oncology approaches rely on molecular profiling which, unfortunately, provides therapeutic options for less than 10% of cancer patients. Functional precision medicine (FPM) complements molecular profiling by combining it with rapid, high-throughput drug testing on live patient cells to identify promising treatment options. In this study, we investigated the efficacy of FPM in the management of pediatric patients with recurrent and/or refractory cancers. We enrolled 25 pediatric/young adult patients with refractory solid or liquid cancers in this clinical trial (number NCT03860376). Enrolled patients represented the breadth of cancer indications generally presenting in pediatric patients: acute lymphoblastic leukemia (3 patients), acute myeloid leukemia (3 patients), astrocytoma (1 patient), ependymoma (1 patient), Ewing’s sarcoma (4 patients), glioblastoma (1 patient), malignant rhabdoid tumor (1 patient), medulloblastoma (1 patient), neuroblastoma (1 patient), osteosarcoma (4 patients), rhabdomyosarcoma (4 patients) and Wilms’ tumor (1 patient). We used a functional ex vivo drug sensitivity test (DST) panel encompassing 40 formulary drugs frequently used at Nicklaus Children’s Hospital and 47 non-formulary drugs approved by FDA for cancer treatment, as well as drugs from phase III and IV clinical trials. Drug sensitivity scores (DSS) were calculated for each drug based on cancer cells’ responses. DST results were then combined with results from targeted mutation profiles to match actionable mutations with selective targeted therapies. FPM and molecular data were prospectively generated and treatment recommendations were provided to an FPM Molecular Tumor Board (MTB) of clinicians. In total, 19 of 25 patients (76%) had complete functional and molecular profiling data provided to the MTB to support clinical decision-making. Six patients had their subsequent treatment guided by FPM recommendations, of which 83% (five of six patients) demonstrated greater than 1.3x increased progression-free survival compared to their previous therapy. Interestingly, hierarchical clustering analysis of DST results shows that patients with the same subtype of cancer do not cluster together, and no cancer subtype is differentially represented in either high-level cluster, suggesting the importance of functional profiling to provide deeper insight into individual patient pharmacological response. This FPM study is the first pediatric cancer study to enroll both solid and hematologic cancers regardless of tumor type, and the first FPM study in the United States to generate prospective treatment data on pediatric oncology patients. We illustrate the feasibility and efficacy of FPM to meet the needs of cancer patients with both liquid and solid tumors, especially for high-risk populations such as pediatric cancer patients. Citation Format: Arlet Maria Acanda de la Rocha, Maggie Fader, Ebony R. Coats, Joseph Dunn, Leat Perez, Carolina Velasquez, Jeanette Galano, Cima Saghira, Ileana Sotto, Yana Vorontsova, Ziad Khatib, Haneen Abdella, Cristina M. Andrade-Feraud, Alexa Jacome, Victoria Reis, Lilliam Rimblas, Nicole Tomas, Paula S. Espinal, Noah Berlow, Tomás R. Guilarte, Jennifer McCafferty-Fernandez, Daria Salyakina, Diana J. Azzam. Efficacy of a functional precision medicine approach in relapsed/refractory pediatric cancer patients: results from a prospective clinical study [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 2 (Clinical Trials and Late-Breaking Research); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(8_Suppl):Abstract nr LB358.
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Nickless, Leah. "What does it take to be an award winner?" Dental Nursing 17, no. 4 (April 2, 2021): 170–71. http://dx.doi.org/10.12968/denn.2021.17.4.170.

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Jerez, Patricia, Hernán Camarero, and María Candela Bernasconi. "Reseñas Vol. 13, Núm. 14 (2016)." Avances del Cesor 13, no. 14 (July 8, 2016): 205–18. http://dx.doi.org/10.35305/ac.v13i14.598.

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Reseña de SOUL, Julia, Somiseros, La configuración y el devenir de un grupo obrero desde una perspectiva antropológica, Prohistoria Ediciones, Rosario, 2014, 306 páginas.Reseña de JEIFETS, Lazar y JEIFETS, Víctor, América Latina en la Internacional Comunista, 1919-1943. Diccionario Biográfico, Ariadna Ediciones, Santiago de Chile, 2015, 791 páginas.Reseña de NICKLAS, Charlotte y POLLEN, Annabella, Dress History: New Directions in Theory and Practice, Bloomsbury Academic, London, 2015, 240 páginas.
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Laufs, Adolf. "Nicklas, Thomas, Macht oder Recht. Frühneuzeitliche Politik im Obersächsischen Reichskreis." Zeitschrift der Savigny-Stiftung für Rechtsgeschichte: Germanistische Abteilung 120, no. 1 (August 1, 2003): 638–40. http://dx.doi.org/10.1515/zrgga.2003.120.1.638.

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29

Tascher, Hans-Joachim. "Mit Kurt Nicklas verliert der FVDZ im Saarland geschätzten Mitstreiter." Der Freie Zahnarzt 59, no. 4 (March 31, 2015): 32. http://dx.doi.org/10.1007/s12614-015-5615-x.

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30

Dragutinović, Predrag. "Stefan Alkier / Christos Karakolis / Tobias Nicklas (прир.), Sola Scriptura Ökumenisch." Theological Views – Religious and Scientific Journal / Теолошки погледи – версконаучни часопис LV, no. 3 (December 30, 2022): 542–45. http://dx.doi.org/10.46825/tv/2022-3-542-545.

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Daly, Glyn. "Åbningen af et filosofisk rum – Interview med Slavoj Žižek." Slagmark - Tidsskrift for idéhistorie, no. 62 (March 9, 2018): 15–32. http://dx.doi.org/10.7146/sl.v0i62.104648.

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In this interview with Glyn Daly, Slavoj Žižek talks about the birth of ‘The Society for Theoretical Psychoanalysis’, and his own overall philosophical approach. He touches upon his intellectual relationship to thinkers such as Martin Heidegger, Jacques Derrida, Immanuel Kant and of course Jacques Lacan. His sources of inspiration are not only these great theorists, but also his four year long day job as a minute taker for the Yugoslavian communist party, and his personal relationship to Jacques-Alain Miller who gives him his psychoanalytical upbringing.Oversat af Nicklas Weis Damkjær
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Shah Abadi, Salma Ebrahimi, Ali Rahmanian, ‏Melika Asadsangabi, Faezeh Yousefie, Seyedeh Mahsa Mortazavi, Shaqayeq Keshtgar, Ashkan Rezvani Joybari, and Hossein Esmaeili. "Evaluation of vaccines effective against coronavirus." Clinical Medicine And Health Research Journal 2, no. 2 (April 18, 2022): 103–8. http://dx.doi.org/10.18535/cmhrj.v2i2.31.

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Given the COVID-19 virus epidemic and vaccination increment all around the world, after surveying the vaccination side effects it was clarified that 72.6% of individuals reported at least one symptom after the first and second injection of Pfizer-BioNTech vaccine which pain at injection site, fever and myalgia/arthralgia were most common among these symptoms. Furthermore, most common severe side effects like fever > 39 °C were perceived more after the second dose of vaccine. In the study of identifying body’s physiologic changed, heart rate variability (HRV) decreased after the first dose and the second dose without having considerable changes in resting heart rate (RHR) and respiratory rate (RR) and the duration of sleep also declined up to 4 days of both vaccination doses. Plus, Local and systemic reactogenicity were more intense after the second dose. Following the COVID-19 vaccination, various allergic reactions also started to promote all around the countries, a questionnaire was adjusted in Toronto-Canada and 65 patients had PEG-ASNase allergy. Rapid reactions like anaphylaxis occur following the first dose of Pfizer mRNA COVID-19 vaccine. In a study consisted of 175 individuals, 21 of them were afflicted with anaphylaxis and a number of 83 individuals experienced non-anaphylaxis allergic reactions but still further studies are required in order to identify the relation between anaphylaxis and COVID-19 vaccines. Disease background is an outstanding factor to intensify COVID-19 infection. In a research, a 40-year old woman who had experienced left peripheral facial nerve palsy 4 years ago and in another research 8 adolescents who visited Nicklaus Children’s Hospital with perimyocarditis within 4 days of receiving the second dose of BNT162b2 vaccine, were investigated in this context. In terms of gender and age relation, a study was carried out on German residents of Bavaria between Jan 9 to Apr 11, 2021 and, it was clarified that both doses of the BioNTech-Pfizer’s BNT162b2 are highly effective against the infection and adverse events of COVID-19 virus in elder people and according to another report, 82% of individuals experienced at least one symptom Following the first dose of Comirnaty vaccine which was more common in women under the age 55 (64%). In a study which was carried out among the workers of Mazandaran University of Medical Sciences in order to identify the side effects of the Sputnik V vaccine, a number of 3236 individuals in the 19-78 age range with the mean age of 38 years old submitted their report. According to a research which was conducted in Bavaria, Germany, the mortality rate was considerably lower in individuals who had received vaccination in relation to not vaccinated individuals, however, 3 death cases were reported in individuals who suffered from comorbidities after receiving the Sputnik vaccine which was considered to be irrelevant to vaccination. A research was conducted to evaluate the effectiveness of Robust antibody after the first and second dose in individuals aged between 70 and 90. From 99 individuals who received the first dose of their vaccination after 3 weeks the existence of Robust antibody was proven in 95% of them and from 86 individuals who received their vaccine’s second dose after 3 weeks, all of them showed a positive result in the test. Furthermore, in another study from 75% of old individuals who were vaccinated at least once, the first dose led into COVID-19 infection decrease and had an effectiveness of 52% in clinical experiments. According to another report, the antibody was observed in 92% of individuals 21 days after the first dose and also in 97% of them 21 days after the second dose it was concluded that Symptoms following vaccination are not unusual and they occur because of body’s immune system response.
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Putnam, Samuel P. "Promise of, Problems with, and Potential Refinement of the “Extremely Short Form of the CBQ”: A Comment on Sleddens, et al. (2012)." Psychological Reports 111, no. 2 (October 2012): 618–20. http://dx.doi.org/10.2466/08.10.21.pr0.111.5.618-620.

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The extremely short (one item, three response options) temperament scale introduced by Sleddens, Hughes, O'Connor, Beltran, Baranowski, Nicklas, et al. (2012) is a valuable contribution that can be useful for future research and applications of temperament. Requiring parents to classify children as high on Effortful Control, Negative Affectivity, or Surgency / Extraversion, however, is counter to the dimensional approach through which these temperament factors were derived. This inappropriate imposition of a typology leads to a degree of imprecision in measurement that may have substantial practical implications. It is recommended that, instead, children be rated on each of these three dimensions. Alternatively, a single-item approach should include choices between groups identified through person-based analyses.
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Mattheis, Lena. "Die Dynamik der Metropolen, edited by Angelika Corbineau-Hoffmann und Pascal Nicklas." Sprache und Literatur 49, no. 2 (December 15, 2020): 335–37. http://dx.doi.org/10.30965/25890859-04902007.

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35

Alexander, S. P., and C. L. Rieder. "Chromosome motion during attachment to the vertebrate spindle: initial saltatory-like behavior of chromosomes and quantitative analysis of force production by nascent kinetochore fibers." Journal of Cell Biology 113, no. 4 (May 15, 1991): 805–15. http://dx.doi.org/10.1083/jcb.113.4.805.

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Before forming a monopolar attachment to the closest spindle pole, chromosomes attaching in newt (Taricha granulosa) pneumocytes generally reside in an optically clear region of cytoplasm that is largely devoid of cytoskeletal components, organelles, and other chromosomes. We have previously demonstrated that chromosome attachment in these cells occurs when an astral microtubule contacts one of the kinetochores (Hayden, J., S. S. Bowser, and C. L. Rieder. 1990. J. Cell Biol. 111:1039-1045), and that once this association is established the chromosome can be transported poleward along the surface of the microtubule (Rieder, C. L., and S. P. Alexander. 1990. J. Cell Biol. 110:81-95). In the study reported here we used video enhanced differential interference contrast light microscopy and digital image processing to compare, at high spatial and temporal resolution (0.1 microns and 0.93 s, respectively), the microtubule-mediated poleward movement of attaching chromosomes and poleward moving particles on the spindle. The results of this analysis demonstrate obvious similarities between minus end-directed particle motion on the newt pneumocyte spindle and the motion of attaching chromosomes. This is consistent with the hypothesis that both are driven by a similar force-generating mechanism. We then used the Brownian displacements of particles in the vicinity of attaching chromosomes to calculate the apparent viscosity of cytoplasm through which the chromosomes were moving. From these data, and that from our kinetic analyses and previous work, we calculate the force-producing potential of nascent kinetochore fibers in newt pneumocytes to be approximately 0.1-7.4 x 10(-6) dyn/microtubule) This is essentially equivalent to that calculated by Nicklas (Nicklas, R.B. 1988. Annu. Rev. Biophys. Biophys. Chem. 17:431-449) for prometaphase (4 x 10(-6) dyn/microtubule) and anaphase (5 x 10(-6) dyn/microtubule) chromosomes in Melanoplus. Thus, within the limits of experimental error, there appears to be a remarkable consistency in force production per microtubule throughout the various stages of mitosis and between groups of diverse taxonomic affinities.
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Horn, Friedrich Wilhelm. "Galater. Novum Testamentum Patristicum, hg. von Andreas Merkt und Tobias Nicklas, Band 9." Zeitschrift für Religions- und Geistesgeschichte 61, no. 2 (2009): 186–88. http://dx.doi.org/10.1163/157007309787838917.

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Knopper, Françoise. "Thomas Nicklas et Matjaž Birk, Aufklärungsdiskurse in der deutschsprachigen Regionalpresse Zentraleuropas, 1800-1920." Les cercles viennois de l'entre-deux-guerres 94 (2022): 263–65. http://dx.doi.org/10.4000/11vej.

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Ostmeyer, Karl-Heinrich. "Tobias Nicklas/Korinna Zamfir (Hg.), Theologies of Creation in Early Judaism and Ancient Christianity." Early Christianity 4, no. 1 (2013): 148. http://dx.doi.org/10.1628/186870313x13624783729245.

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Fletcher, Marvin, and Bradley Biggs. "The Triple Nickles: America's First All-Black Paratroop Unit." Military Affairs 51, no. 4 (October 1987): 213. http://dx.doi.org/10.2307/1987969.

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Zeng, Xiaochen. "A note on wavelet deconvolution density estimation." International Journal of Wavelets, Multiresolution and Information Processing 15, no. 06 (November 2017): 1750055. http://dx.doi.org/10.1142/s0219691317500552.

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This paper discusses the uniformly strong convergence of multivariate density estimation with moderately ill-posed noise over a bounded set. We provide a convergence rate over Besov spaces by using a compactly supported wavelet. When the model degenerates to one-dimensional noise-free case, the convergence rate coincides with that of Giné and Nickl’s (Ann. Probab., 2009 or Bernoulli, 2010). Our result can also be considered as an extension of Masry’s theorem (Stoch. Process. Appl., 1997) to some extent.
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Guo, Huijun, and Junke Kou. "Strong Uniform Convergence Rates of Wavelet Density Estimators with Size-Biased Data." Journal of Function Spaces 2019 (March 6, 2019): 1–6. http://dx.doi.org/10.1155/2019/7102346.

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This paper considers the strong uniform convergence of multivariate density estimators in Besov space Bp,qs(Rd) based on size-biased data. We provide convergence rates of wavelet estimators when the parametric μ is known or unknown, respectively. It turns out that the convergence rates coincide with that of Giné and Nickl’s (Uniform Limit Theorems for Wavelet Density Estimators, Ann. Probab., 37(4), 1605-1646, 2009), when the dimension d=1, p=q=∞, and ω(y)≡1.
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Szalai, Béla. "Augustin Hirschvogel metszetei az 1549. évi hadjáratról." Magyar Könyvszemle 137, no. 2 (December 1, 2021): 266–71. http://dx.doi.org/10.17167/mksz.2021.2.266-271.

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Az 1548 októberében Pozsonyban tartott országgyűlés határozatot hozott Balassa Menyhért és Basó Mátyás Léva és Murány környéki garázdálkodásának felszámolására. Az 1549 tavaszán indított büntető hadjárat fővezére az ifjabb Nicklas Salm császári generális volt. Elsőként Balassa Menyhért ellen vonultak. Balassa Menyhért várait katonasággal megerősítette, de ő maga Erdélybe menekült János Zsigmond választott magyar királyhoz. Salm hadai először Szitnya várát foglalták el, majd megkezdték Léva ostromát, amit április 22-én adtak fel védői. Ezután körbezárták Csábrágot, amit június 5-én kerítették kézre. Murány ostromát az ekkorra már hozzájuk csatlakozott Bebek Ferenc csapataival együtt július 5-én kezdték meg, a várostromokban legjártasabb Bernardo de Aldana irányításával. Basó Mátyás a vár rendkívül jó terepadottságainak is köszönhetően a mintegy tízszeres túlerő ellen negyven napig tudta tartani Murányt, amit végül augusztus 15-én foglaltak el Salm csapatai. Az ostrom vége felé Basó Mátyás kiszökött a várból, de pár nappal később elfogták, testvérével, Mártonnal és 12 katonájával együtt kivégezték.1 A hadjárat eseményeit Tinódi Lantos Sebestyén is megörökítette.
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Agnesdotter, Carina, Tanja Von Dahlern, Johanna Sjöstedt, Ann Steiner, Göran Rossholm, Maria Nilson, and Nicklas Hållén. "Recensioner." Tidskrift för litteraturvetenskap 46, no. 1 (January 1, 2016): 71–89. http://dx.doi.org/10.54797/tfl.v46i1.8803.

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Nicklas Hållén om WARWICK RESEARCH COLLECTIVECOMBINED AND UNEVEN DEVELOPMENT. TOWARDS A NEW THEORY OF WORLD-LITERATURELiverpool: Liverpool University Press, 2015 (196 s.) Maria Nilson om DAG HEDMAN & JERRY MÄÄTTÄ (RED.)BROTT, KÄRLEK, FRÄMMANDE VÄRLDAR. TEXTER OM POPULÄRLITTERATURLund: Studentlitteratur, 2015 (509 s.) Göran Rossholm om INGEBORG LÖFGRENINTERPRETIVE SKEPTICISM. STANLEY CAVELL, NEW CRITICISM, AND LITERARY INTERPRETATIONUppsala: Acta Universitatis Upsaliensis, 2015, 366 s. (diss. Uppsala) Ann Steiner om MOA MATTHIS”TAKE A TASTE”. SELLING ISAK DINESEN’S SEVEN GOTHIC TALES IN 1934Umeå: Institutionen för språkstudier, Umeå Universitet, 2014, 200 s. (diss. Umeå) Johanna Sjöstedt om TOVE PETTERSEN & ANNLAUG BJØRSNØS (RED.)SIMONE DE BEAUVOIR. A HUMANIST THINKERLeiden och Boston: Brill Rodopi 2015, 215 s. Tanja von Dahlern om EMMA TORNBORGWHAT LITERATURE CAN MAKE US SEE. POETRY, INTERMEDIALITY, MENTAL IMAGERYMalmö: Bokbox, 2014, 160 s. (diss. Linnéuniversitetet) Carina Agnesdotter om EBBA WITT-BRATTSTRÖMSTÅ I BREDD. 70-TALETS KVINNOR, MÄN OCH LITTERATURStockholm: Norstedts, 2014, 280 s.
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Rooks, Isaac. "Katarina Gregersdotter, Johan Höglund, and Nicklas Hållén, Eds. Animal Horror Cinema: Genre, History and Criticism." Humanimalia 9, no. 2 (February 5, 2018): 208–13. http://dx.doi.org/10.52537/humanimalia.9549.

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Stenschke, Christoph. "Prophets and prophecy in early Christian literature. By Verheyden, Joseph, Korinna Zamfir, Tobias Nicklas (eds)." Journal for Semitics 26, no. 1 (August 30, 2017): 567–69. http://dx.doi.org/10.25159/1013-8471/3139.

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Zelyck, Lorne. "The Other Side: Apocryphal Perspectives on Ancient Christian "Orthodoxies" ed. by Tobias Nicklas et al." Catholic Biblical Quarterly 80, no. 4 (2019): 758–59. http://dx.doi.org/10.1353/cbq.2019.0042.

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Mil, J. W. F. "John Sexton, Gareth Nickless and Chris Green, Pharmaceutical Care Made Easy." Pharmacy World & Science 29, no. 6 (April 12, 2007): 704. http://dx.doi.org/10.1007/s11096-007-9119-x.

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Kleiner, Scott A. "Serendipity and Vision: Two Methods for Discovery Comments on Nickles." Biology & Philosophy 14, no. 1 (January 1999): 55–63. http://dx.doi.org/10.1023/a:1006550216230.

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Schmid, U. "New Testament Manuscripts: Their Texts and Their World. Edited by THOMAS J. KRAUS and TOBIAS NICKLAS." Journal of Theological Studies 59, no. 1 (February 6, 2008): 254–56. http://dx.doi.org/10.1093/jts/flm186.

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Chen, Yue, De-Yi Zheng, and Yu-Ying Wang. "Doping for inducing the formation of lead niobate-nicklate in piezo-ceramics." Journal of Alloys and Compounds 845 (December 2020): 155903. http://dx.doi.org/10.1016/j.jallcom.2020.155903.

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