Academic literature on the topic 'Nicotinamide adenine dinucleotide'

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Journal articles on the topic "Nicotinamide adenine dinucleotide"

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Xu, Xiaowen, Xinxin Wang, Li Zhang, et al. "Nicotinamide adenine dinucleotide treatment confers resistance to neonatal ischemia and hypoxia: effects on neurobehavioral phenotypes." Neural Regeneration Research 19, no. 12 (2024): 2760–72. http://dx.doi.org/10.4103/nrr.nrr-d-23-01490.

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JOURNAL/nrgr/04.03/01300535-202412000-00031/figure1/v/2024-04-08T165401Z/r/image-tiff Neonatal hypoxic-ischemic brain injury is the main cause of hypoxic-ischemic encephalopathy and cerebral palsy. Currently, there are few effective clinical treatments for neonatal hypoxic-ischemic brain injury. Here, we investigated the neuroprotective and molecular mechanisms of exogenous nicotinamide adenine dinucleotide, which can protect against hypoxic injury in adulthood, in a mouse model of neonatal hypoxic-ischemic brain injury. In this study, nicotinamide adenine dinucleotide (5 mg/kg) was intraperit
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Alberty, R. A. "Thermodynamics of Reactions of Nicotinamide Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Phosphate." Archives of Biochemistry and Biophysics 307, no. 1 (1993): 8–14. http://dx.doi.org/10.1006/abbi.1993.1552.

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Micheli, Vanna, H. Anne Simmonds, and Carlo Ricci. "Regulation of nicotinamide–adenine dinucleotide synthesis in erythrocytes of patients with hypoxanthine–guanine phosphoribosyltransferase deficiency and a patient with phosphoribosylpyrophosphate synthetase superactivity." Clinical Science 78, no. 2 (1990): 239–45. http://dx.doi.org/10.1042/cs0780239.

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1. The synthesis of nicotinamide–adenine dinucleotide from nicotinamide and nicotinic acid was compared over different time scales at both physiological (0.7 μmol/l) and high (0.2–3 mmol/l) substrate concentrations in erythrocytes from three patients with hypoxanthine–guanine phosphoribosyltransferase (hypoxanthine phosphoribosyltransferase, EC 2.4.2.8) deficiency (including one Lesch–Nyhan patient) and from one patient with phosphoribosylpyrophosphate synthetase superactivity. The above disorders are associated with grossly altered erythrocyte nicotinamide-adenine dinucleotide levels. 2. At t
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Arsić, Biljana. "Mechanisms of actions of coenzymes." Chemia Naissensis 1, no. 1 (2018): 153–86. http://dx.doi.org/10.46793/chemn1.1.153a.

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Each living species uses coenzymes in numerous important reactions catalyzed by enzymes. There are two types of coenzymes depending on the interaction with apoenzymes: coenzymes frequently called co-substrates and coenzymes known as prosthetic groups. Main metabolic roles of co-substrates (adenosine triphosphate (ATP), S-adenosyl methionine, uridine diphosphate glucose, nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+), coenzyme A (CoA), tetrahydrofolate and ubiquinone (Q)) and prosthetic groups (flavin mononucleotide (FMN) and flavin adenine dinu
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Frederick, David W., Sophie Trefely, Alexia Buas, et al. "Stable isotope labeling by essential nutrients in cell culture (SILEC) for accurate measurement of nicotinamide adenine dinucleotide metabolism." Analyst 142, no. 23 (2017): 4431–37. http://dx.doi.org/10.1039/c7an01378g.

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Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are conserved metabolic cofactors that mediate reduction-oxidation (redox) reactions throughout all domains of life.
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Lee, H. J., and G. G. Chang. "Interactions of nicotinamide-adenine dinucleotide phosphate analogues and fragments with pigeon liver malic enzyme. Synergistic effect between the nicotinamide and adenine moieties." Biochemical Journal 245, no. 2 (1987): 407–14. http://dx.doi.org/10.1042/bj2450407.

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The structural requirements of the NADP+ molecule as a coenzyme in the oxidative decarboxylation reaction catalysed by pigeon liver malic enzyme were studied by kinetic and fluorimetric analyses with various NADP+ analogues and fragments. The substrate L-malate had little effect on the nucleotide binding. Etheno-NADP+, 3-acetylpyridine-adenine dinucleotide phosphate, and nicotinamide-hypoxanthine dinucleotide phosphate act as alternative coenzymes for the enzyme. Their kinetic parameters were similar to that of NADP+. Thionicotinamide-adenine dinucleotide phosphate, 3-aminopyridine-adenine din
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Pankiewicz, K., L. Chen, R. Petrelli, et al. "Nicotinamide Adenine Dinucleotide Based Therapeutics." Current Medicinal Chemistry 15, no. 7 (2008): 650–70. http://dx.doi.org/10.2174/092986708783885282.

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Kova´rˇ, J., J. Tura´nek, C. Hlava´cˇ, V. Vala, and V. Kahle. "Liquid chromatographic separations of dimers of nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate." Journal of Chromatography A 319 (January 1985): 341–49. http://dx.doi.org/10.1016/s0021-9673(01)90570-9.

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Merk, Virginia, Eugen Speiser, Wolfgang Werncke, Norbert Esser, and Janina Kneipp. "pH-Dependent Flavin Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Ultraviolet Resonance Raman (UVRR) Spectra at Intracellular Concentration." Applied Spectroscopy 75, no. 8 (2021): 994–1002. http://dx.doi.org/10.1177/00037028211025575.

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The ultraviolet resonance Raman spectra of the adenine-containing enzymatic redox cofactors nicotinamide adenine dinucleotide and flavin adenine dinucleotide in aqueous solution of physiological concentration are compared with the aim of distinguishing between them and their building block adenine in potential co-occurrence in biological materials. At an excitation wavelength of 266 nm, the spectra are dominated by the strong resonant contribution from adenine; nevertheless, bands assigned to vibrational modes of the nicotinamide and the flavin unit are found to appear at similar signal streng
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Stockman, Brian J., Ian J. Lodovice, Douglas A. Fisher, Alexander S. Mccoll, and Zhi Xie. "A Nuclear Magnetic Resonance–Based Functional Assay for Nicotinamide Adenine Dinucleotide Synthetase." Journal of Biomolecular Screening 12, no. 4 (2007): 457–63. http://dx.doi.org/10.1177/1087057107299717.

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Nicotinamide adenine dinucleotide synthetase (NadE) is an essential enzyme for bacterial pathogens and is thus a promising antibacterial target. It catalyzes the conversion of nicotinic acid adenine dinucleotide to nicotinamide adenine dinucleotide. Changes in chemical shifts that occur in the nicotinic acid ring as it is converted to nicotinamide can be used for monitoring the reaction. A robust nuclear magnetic resonance—based activity assay was developed using robotically controlled reaction initiation and quenching. The single-enzyme assay has less potential for false positives compared to
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Dissertations / Theses on the topic "Nicotinamide adenine dinucleotide"

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Moideen, Abdul Nazeer. "Nicotinamide adenine dinucleotide biosynthesis enzymes in rheumatoid arthritis." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/97161/.

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Introduction: Synovial fibroblasts (SF) display a ‘hyperactive’ phenotype in patients with rheumatoid arthritis (RA). Nicotinamide adenine dinucleotide (NAD+) plays a role in cell metabolism, but may also be a key molecule in maintaining this ‘activated’ phenotype. NAD+ can be synthesised from precursor vitamin molecules, nicotinamide (Nam), nicotinic acid (NA) and Tryptophan (TRP); with their respective phosphoribosyl transferases (NAMPT, NAPRT, QAPRT) and Indoleamine (IDO) being the rate limiting enzymes involved in these pathways. NAMPT and IDO are known to be elevated in RA synovial tissue
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Stevenson, Eileen C. "The utilisation of fibre-entrapped cells within a novel bioreactor for the production of NADH." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334643.

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Trammell, Samuel A. J. "Novel NAD+ metabolomic technologies and their applications to Nicotinamide Riboside interventions." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3203.

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Nicotinamide adenine dinucleotide (NAD+) is a cofactor in hydride transfer reactions and consumed substrate of several classes of glycohydrolyitc enzymes, including sirtuins. NAD+, its biosynthetic intermediates, breakdown products, and related nucleotides (the NAD metabolome) is altered in many metabolic disorders, such as aging and obesity. Supplementation with the novel NAD+ precursor, nicotinamide riboside (NR), ameliorates these alterations and opposes systemic metabolic dysfunctions in rodent models. Based on the hypothesis that perturbations of the NAD metabolome are both a symptom and
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Al, Ghouleh Imad 1977. "The role of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase in endothelial activation in sepsis /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115854.

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Septic shock is a leading cause of death in intensive care units. As part of the septic process, the endothelium becomes activated and propagates the septic condition. It has become evident that reactive oxygen species (ROS) are involved in the signaling of mediators of sepsis, such as tumor necrosis factor-alpha (TNF-alpha) and the lipopolysaccharide coating of gram-negative bacteria (LPS). An important source of these ROS is NADPH oxidase, which is a ubiquitously expressed enzyme complex that also exists in endothelial cells (EC). We showed that O2- from NADPH oxidase was important for LPS,
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Pergolizzi, Giulia. "Novel derivatives of nicotinamide adenine dinucleotide (NAD) and their biological evaluation against NAD-consuming enzymes." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42447/.

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Nicotinamide adenine dinucleotide (β-NAD+) is a primary metabolite involved in fundamental biological processes. Its molecular structure with characteristic functional groups, such as the quaternary nitrogen of the nicotinamide ring, and the two high-energy pyrophosphate and nicotinamide N-glycosidic bonds, allows it to undergo different reactions depending on the reactive moiety. Well known as a redox substrate owing to the redox properties of the nicotinamide ring, β-NAD+ is also fundamental as a substrate of NAD+-consuming enzymes that cleave either high-energy bonds to catalyse their react
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Balico, Laís de Lourdes de Lima. "Caracterização molecular e bioquímica de um transportador mitocondrial de nicotinamida adenina dinucleotídeo de Aspergillus fumigatus." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-17042015-135749/.

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O A. fumigatus é um fungo saprofítico e tornou-se um dos principais agente patogênico oportunista em pacientes imunossuprimidos. Estudos prévios em nosso laboratório foi demonstrado que em mitocôndrias de P. brasiliensis e de A. fumigatus, o NAD+ era capaz de induzir a formação de potencial de membrana mitocondrial, o qual podia ser dissipado por FCCP, sugerindo a presença de um transportador de NAD+/NADH, conforme havia sido descrito em S. cerevisiae. Através de ferramentas de bioinformática, foi identificado no Aspergillus Gene Database, uma sequência com 32% de identidade com o gene ndt1p d
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Preyat, Nicolas. "Tumor necrosis factor-induced necroptosis is regulated by nicotinamide adenine dinucleotide in a sirtuin-dependent manner." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209470.

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Nicotinamide adenine dinucleotide (NAD+) represents a long-known key molecule in cellular metabolism. It was initially identified for its ability to convey electrons and protons between redox partners in multiple bioenergetic and biosynthetic reactions. In addition, NAD+ also serves as a substrate for NAD+-consuming enzymes such as sirtuins and poly ADP-ribose polymerases (PARPs). These latter enzymes catalyze dynamic post-translational modifications that control virtually every signaling pathway orchestrating cell fate. The aim of this work was to analyze the role of NAD+ in the context of pr
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Smyth, Lisa M. "The nicotinamide adenine dinucleotide (NAD)/cyclic ADP-ribose/ADP-ribose system, new to the peripheral synapse." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3210943.

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BERTRAND, MARTINE. "Photoreduction du nicotinamide adenine dinucleotide phosphate par des etioplastes de haricot (phaseolus vulgaris l. Var commodore)." Paris 6, 1988. http://www.theses.fr/1988PA066079.

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Brunnbauer, Philipp [Verfasser]. "On the measurement and systemic relevance of extracellular nicotinamide adenine dinucleotide in human plasma / Philipp Brunnbauer." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1206185988/34.

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Books on the topic "Nicotinamide adenine dinucleotide"

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Jackson, J. B. The proton-translocating nicotinamide adenine dinucleotide transhydrogenase. New York, 1991.

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Rissiek, Björn, Andreas H. Guse, Sahil Adriouch, and Santina Bruzzone, eds. The Versatile Role of Nicotinamide Adenine Dinucleotide in Immunity. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88974-085-7.

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French, Benjamin. Proposed Effects of Nicotinamide Adenine Dinucleotide (Nad) Supplementation on Energy Metabolism. GRIN Verlag GmbH, 2015.

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Pfeifer, Christine. Eigenschaften von Alkohol-Dehydrogenase und Glutamat-Dehydrogenase nach kovalenter Fixierung an Nicotinamid-Adenin-Dinucleotid. 1992.

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Book chapters on the topic "Nicotinamide adenine dinucleotide"

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Andrews, Anne M., Greg A. Gerhardt, Lynette C. Daws, et al. "Nicotinamide Adenine Dinucleotide." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_1030.

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Clausen, Torben, José Luis Trejo, Mark P. Mattson, et al. "Nicotinamide Adenine Dinucleotide." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_2763.

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Ziegler, Mathias. "Nicotinamide Adenine Dinucleotide (NAD)." In Encyclopedia of Biophysics. Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-16712-6_42.

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Riley, David S. "Nicotinamide adenine dinucleotide (NAD)." In Materia Medica of New and Old Homeopathic Medicines. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-25292-1_48.

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Jiang, Zhi, Li Luo, Yuanyuan Qin, Yuyu Huang, and Shuai Yan. "Nicotinamide Adenine Dinucleotide and Aging." In Biology of Nicotinamide Coenzymes. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9877-3_28.

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Mou, Yu-Jie, and Zheng-Hong Qin. "Nicotinamide Adenine Dinucleotide and Immunoregulation." In Biology of Nicotinamide Coenzymes. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9877-3_18.

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Cheng, Ying, Da-Chuang Yang, and Fang Lin. "Nicotinamide Adenine Dinucleotide and Alzheimer’s Disease." In Biology of Nicotinamide Coenzymes. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9877-3_34.

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Xu, Hai-Dong, Ding-Mei Zhang, Mei-Ling Sun, and Zheng-Hong Qin. "Nicotinamide Adenine Dinucleotide and Signaling Transduction." In Biology of Nicotinamide Coenzymes. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9877-3_17.

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Cheng, Ying, Da-Chuang Yang, and Fang Lin. "Nicotinamide Adenine Dinucleotide and Parkinson’s Disease." In Biology of Nicotinamide Coenzymes. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9877-3_35.

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Zhao, Kai, Jiang Zhu, and Rui Sheng. "Nicotinamide Adenine Dinucleotide and Heart Disease." In Biology of Nicotinamide Coenzymes. Springer Nature Singapore, 2025. https://doi.org/10.1007/978-981-97-9877-3_23.

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Conference papers on the topic "Nicotinamide adenine dinucleotide"

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Sharma, Ashutosh. "Novel reduced nicotinamide adenine dinucleotide optical sensor." In OE/LASE '94, edited by James A. Harrington, David M. Harris, Abraham Katzir, and Fred P. Milanovich. SPIE, 1994. http://dx.doi.org/10.1117/12.180770.

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Hristovska, Talija, Kosta Petrović, Marko Cincović, et al. "UTICAJ APLIKACIJE NIACINA NA VREDNOST NJEGOVIH VITAMERA U KRVI KRAVA U RANOJ LAKTACIJI." In XXVII savetovanje o biotehnologiji. University of Kragujevac, Faculty of Agronomy, 2022. http://dx.doi.org/10.46793/sbt27.263h.

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Vitamin niacin is of great importance for energy metabolism. Physiological niacin is incorporated into the coenzyme nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP). The aim of this study was to determine the concentration of NAD and NADP in the blood of cows during the application of niacin in the peripartum period. The value of these vitamins depends on the peripartum week, regardless of the constant exogenous source of niacin.
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Ravi, Vidhya Shree, Abigail J. Clevenger, Sam Morganti, Shreya A. Raghavan, and Alex J. Walsh. "Unveiling the Metabolic Diversity in Cancer: Quantifying Cancer Stem Cells and Bulk Cancer Cells Through FLIM Imaging and Computational Analysis." In Clinical and Translational Biophotonics. Optica Publishing Group, 2024. http://dx.doi.org/10.1364/translational.2024.tw1b.2.

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This study tests the hypothesis that Fluorescence Lifetime Imaging Microscopy (FLIM) of the endogenous metabolic co-enzymes (nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FAD)) provides insights into the metabolic signatures of CSCs and bulk tumor cells. By identifying and quantifying metabolic differences, researchers can potentially develop tailored therapies that address both CSCs and bulk tumor cells, improving therapeutic outcomes and addressing the challenges posed by tumor heterogeneity.
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Ghukasyan, Vladimir V., and Fu-Jen Kao. "Monitoring Cellular Metabolism with Fluorescence Lifetime of Reduced Nicotinamide Adenine Dinucleotide." In Asia Communications and Photonics Conference and Exhibition. OSA, 2009. http://dx.doi.org/10.1364/acp.2009.fe4.

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Sipos, Áron, Rita Nagypál, Ferenc Sarlós, and Géza I. Groma. "Vibrational relaxation demonstrated in nicotinamide adenine dinucleotide applying machine learning based analysis." In IX. Szimpózium a hazai kvantumelektronikai kutatások eredményeiről. Szegedi Tudományegyetem Természettudományi és Informatikai Kar Fizikai Intézet, 2021. http://dx.doi.org/10.14232/kvantumelektronika.9.30.

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Sharma, Ashutosh. "Novel fluorescence method for development of nicotinamide adenine dinucleotide and secondary biosensors." In OE/LASE '94, edited by James A. Harrington, David M. Harris, Abraham Katzir, and Fred P. Milanovich. SPIE, 1994. http://dx.doi.org/10.1117/12.180768.

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Schramm, Werner, Mathias Nittka, Wolfgang Hoehne, Heinz D. Kronfeldt, and Joerg Rauschenberg. "Registration of damages of endothelial cell cultures by beta-nicotinamide adenine dinucleotide (NADH) fluorescence." In International Symposium on Biomedical Optics Europe '94, edited by Hans-Jochen Foth, Aaron Lewis, Halina Podbielska, Michel Robert-Nicoud, Herbert Schneckenburger, and Anthony J. Wilson. SPIE, 1995. http://dx.doi.org/10.1117/12.200883.

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Pan, Fu-shih, Stephen Chen, Robert A. Mintzer, Chin-Tu Chen, and Paul Schumacker. "Studies of yeast cell oxygenation and energetics by laser fluorometry of reduced nicotinamide adenine dinucleotide." In Midwest - DL tentative, edited by Rudolph P. Guzik, Hans E. Eppinger, Richard E. Gillespie, Mary K. Dubiel, and James E. Pearson. SPIE, 1991. http://dx.doi.org/10.1117/12.25761.

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Melton, Sarah, Tamara Morris, Ashley Henderson, et al. "Nicotinamide Adenine Dinucleotide (NAD) Attenuates the Rate-Decreasing Effects of Oxycodone Withdrawal in Rats with No Apparent Abuse Liability." In ASPET 2023 Annual Meeting Abstracts. American Society for Pharmacology and Experimental Therapeutics, 2023. http://dx.doi.org/10.1124/jpet.122.560400.

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Moreno-Vinasco, Liliana, Saad Sammani, Hector Quijada, et al. "Extracellular Nicotinamide Adenine Dinucleotide (NAD) Is Protective In Acute Lung Injury (ALI) And ALI-Ventilator-Induced Lung Injury (VILI)." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a5455.

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Reports on the topic "Nicotinamide adenine dinucleotide"

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หลุยเจริญ ชีพสุนทร, ชาลิสา, та พูลลาภ ชีพสุนทร. ผลของภาวะพร่องเอนไซม์ G6PD ต่อการเสื่อมของเซลล์ไตในโรคเบาหวาน. คณะแพทยศาสตร์ จุฬาลงกรณ์มหาวิทยาลัย, 2018. https://doi.org/10.58837/chula.res.2018.30.

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เอนไซม์ glucose 6-phosphate dehydrogenase (G6PD) เป็นเอนไซม์ที่พบได้ในทุกเซลล์ของร่างกาย มีหน้าที่สร้าง nicotinamide adenine dinucleotide (NADPH) จากวิถี pentose phosphate pathway (PPP) เพื่อช่วยป้องกันภาวะ oxidative stress ภายในเซลล์ด้วยการรักษาระดับ reduced glutathione (GSH) ความผิดปกติที่เกิดขึ้นกับเอนไซม์ G6PD ส่งผลกระทบต่อเซลล์จากภาวะ oxidative stress เช่น ภาวะพร่องเอนไซม์ G6PD สามารถเหนี่ยวนำให้เซลล์ไตเกิด apoptosis และ nephropathy นอกจากนี้ยังพบภาวะพร่องเอนไซม์ G6PD เพิ่มสูงขึ้นในผู้ป่วยเบาหวานเมื่อเทียบกับคนปกติ ด้วยเหตุนี้จึงเป็นที่มาของการศึกษาวิจัยบทบาทของภาวะพร่องเอนไซม์ G6PD ในเซล
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