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Dissertations / Theses on the topic 'Nicotinamide adenine dinucleotide'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Moideen, Abdul Nazeer. "Nicotinamide adenine dinucleotide biosynthesis enzymes in rheumatoid arthritis." Thesis, Cardiff University, 2016. http://orca.cf.ac.uk/97161/.

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Introduction: Synovial fibroblasts (SF) display a ‘hyperactive’ phenotype in patients with rheumatoid arthritis (RA). Nicotinamide adenine dinucleotide (NAD+) plays a role in cell metabolism, but may also be a key molecule in maintaining this ‘activated’ phenotype. NAD+ can be synthesised from precursor vitamin molecules, nicotinamide (Nam), nicotinic acid (NA) and Tryptophan (TRP); with their respective phosphoribosyl transferases (NAMPT, NAPRT, QAPRT) and Indoleamine (IDO) being the rate limiting enzymes involved in these pathways. NAMPT and IDO are known to be elevated in RA synovial tissue

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2

Stevenson, Eileen C. "The utilisation of fibre-entrapped cells within a novel bioreactor for the production of NADH." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334643.

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3

Trammell, Samuel A. J. "Novel NAD+ metabolomic technologies and their applications to Nicotinamide Riboside interventions." Diss., University of Iowa, 2016. https://ir.uiowa.edu/etd/3203.

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Nicotinamide adenine dinucleotide (NAD+) is a cofactor in hydride transfer reactions and consumed substrate of several classes of glycohydrolyitc enzymes, including sirtuins. NAD+, its biosynthetic intermediates, breakdown products, and related nucleotides (the NAD metabolome) is altered in many metabolic disorders, such as aging and obesity. Supplementation with the novel NAD+ precursor, nicotinamide riboside (NR), ameliorates these alterations and opposes systemic metabolic dysfunctions in rodent models. Based on the hypothesis that perturbations of the NAD metabolome are both a symptom and

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4

Al, Ghouleh Imad 1977. "The role of nicotinamide adenine dinucleotide phosphate (reduced form) oxidase in endothelial activation in sepsis /." Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=115854.

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Septic shock is a leading cause of death in intensive care units. As part of the septic process, the endothelium becomes activated and propagates the septic condition. It has become evident that reactive oxygen species (ROS) are involved in the signaling of mediators of sepsis, such as tumor necrosis factor-alpha (TNF-alpha) and the lipopolysaccharide coating of gram-negative bacteria (LPS). An important source of these ROS is NADPH oxidase, which is a ubiquitously expressed enzyme complex that also exists in endothelial cells (EC). We showed that O2- from NADPH oxidase was important for LPS,

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5

Pergolizzi, Giulia. "Novel derivatives of nicotinamide adenine dinucleotide (NAD) and their biological evaluation against NAD-consuming enzymes." Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/42447/.

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Nicotinamide adenine dinucleotide (β-NAD+) is a primary metabolite involved in fundamental biological processes. Its molecular structure with characteristic functional groups, such as the quaternary nitrogen of the nicotinamide ring, and the two high-energy pyrophosphate and nicotinamide N-glycosidic bonds, allows it to undergo different reactions depending on the reactive moiety. Well known as a redox substrate owing to the redox properties of the nicotinamide ring, β-NAD+ is also fundamental as a substrate of NAD+-consuming enzymes that cleave either high-energy bonds to catalyse their react

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6

Balico, Laís de Lourdes de Lima. "Caracterização molecular e bioquímica de um transportador mitocondrial de nicotinamida adenina dinucleotídeo de Aspergillus fumigatus." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/60/60135/tde-17042015-135749/.

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O A. fumigatus é um fungo saprofítico e tornou-se um dos principais agente patogênico oportunista em pacientes imunossuprimidos. Estudos prévios em nosso laboratório foi demonstrado que em mitocôndrias de P. brasiliensis e de A. fumigatus, o NAD+ era capaz de induzir a formação de potencial de membrana mitocondrial, o qual podia ser dissipado por FCCP, sugerindo a presença de um transportador de NAD+/NADH, conforme havia sido descrito em S. cerevisiae. Através de ferramentas de bioinformática, foi identificado no Aspergillus Gene Database, uma sequência com 32% de identidade com o gene ndt1p d

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7

Preyat, Nicolas. "Tumor necrosis factor-induced necroptosis is regulated by nicotinamide adenine dinucleotide in a sirtuin-dependent manner." Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209470.

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Nicotinamide adenine dinucleotide (NAD+) represents a long-known key molecule in cellular metabolism. It was initially identified for its ability to convey electrons and protons between redox partners in multiple bioenergetic and biosynthetic reactions. In addition, NAD+ also serves as a substrate for NAD+-consuming enzymes such as sirtuins and poly ADP-ribose polymerases (PARPs). These latter enzymes catalyze dynamic post-translational modifications that control virtually every signaling pathway orchestrating cell fate. The aim of this work was to analyze the role of NAD+ in the context of pr

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8

Smyth, Lisa M. "The nicotinamide adenine dinucleotide (NAD)/cyclic ADP-ribose/ADP-ribose system, new to the peripheral synapse." abstract and full text PDF (free order & download UNR users only), 2005. http://0-gateway.proquest.com.innopac.library.unr.edu/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3210943.

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9

BERTRAND, MARTINE. "Photoreduction du nicotinamide adenine dinucleotide phosphate par des etioplastes de haricot (phaseolus vulgaris l. Var commodore)." Paris 6, 1988. http://www.theses.fr/1988PA066079.

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10

Brunnbauer, Philipp [Verfasser]. "On the measurement and systemic relevance of extracellular nicotinamide adenine dinucleotide in human plasma / Philipp Brunnbauer." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2020. http://d-nb.info/1206185988/34.

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11

Sato, Yuichi. "Palmitate induces reactive oxygen species production and β-cell dysfunction by activating nicotinamide adenine dinucleotide phosphate oxidase through Src signaling". Kyoto University, 2014. http://hdl.handle.net/2433/188633.

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12

Sheridan, Scott D. "Partial purification and characterization of F₄₂₀-dependent NADP reductase from Methanobrevibacter smithii strain DE1." PDXScholar, 1985. https://pdxscholar.library.pdx.edu/open_access_etds/3523.

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The F420-dependent NADP reductase of Methanobrevibacter smithii has been partially purified employing a combination of affinity chromatography with Blue Sepharose (Cl-6B) and molecular sieve chromatography with Sephacryl S-200, The enzyme, which requires reduced F420 as an electron donor, has been purified over 145 fold with a recovery of 6%. A molecular weight of 120,00 for the native enzyme was determined by Sephacryl S-200 chromatography. A subunit molecular weight of 28,200 was determined by SDS-PAGE, indicating that the native enzyme is a tetramer. The optimal temperature for enzymatic ac

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13

Cao, Peter. "Age-related structural changes in the liver of old mice with SIRT1 overexpression in conjunction with NMN supplementation." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/16872.

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Ageing is associated with ultrastructural changes in the liver, including a reduction in hepatocyte mitochondrial number density and porosity of the liver sinusoidal cells. Histologically-verifiable changes include lipid and collagen accumulation, and increased perisinusoidal von Willebrand factor (VWF) expression. Sirtuin 1 (SIRT1), an NAD+-dependent deacetylase, is renowned for its range of anti-ageing actions. This study evaluated whether the anti-ageing effects of SIRT1 would extend to these liver ageing characteristics. Here the effects of whole-body SIRT1 overexpression on the livers of

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14

Ali, Irshad. "Electrochemical investigations of the interactive behavior of Nicotinamide Adenine Dinucleotide (NAD+/NADH) with electrode surfaces: towards direct electrochemical regeneration of enzymatically-active NADH." Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117104.

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Nicotinamide adenine dinucleotide NAD(H) is a co-enzyme which participates in a large number of biochemical processes in which it acts as a hydrogen and electron carrier. Hence, NAD(H) is found in two redox forms: oxidized, NAD+, and reduced, 1,4-NADH. Despite its high potential industrial use, due to its very high cost (especially that of 1,4-NADH) and the need to be added in a biochemical reactor in stoichiometric quantities, its current use is very limited. Hence, there is a need to develop in-situ 1,4-NADH regeneration methods. Electrochemical methods are of particular interest because of

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15

Gouasmi, Roumaïssa. "Rôles du NAD dans la plasticité cellulaire cancéreuse." Electronic Thesis or Diss., Lyon 1, 2025. http://www.theses.fr/2025LYO10011.

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La voie de la kynurénine a longtemps été considérée comme une suite linéaire de réactions enzymatiques. Nous avons récemment émis l’hypothèse qu’elle fonctionne davantage comme deux modules successifs. Le premier, en réponse à l’activation des enzymes IDO et TDO, permet la synthèse de métabolites dotés de propriétés immunosuppressives et contribue à l’homéostasie intestinale en condition inflammatoire. Son activation aberrante dans les cancers colorectaux présente des effets protumoraux multiples en facilitant l’évasion immunitaire, la vascularisation et la dissémination métastatique. Le secon

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16

Botta, Davide. "Strategies for structural studies of poly(ADP-ribose) glycohydrolase: Towards the validation of a novel therapeutic target." Diss., The University of Arizona, 2010. http://hdl.handle.net/10150/145718.

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Poly(ADP-ribosyl)ation is a reversible post-translational modification of histones and nuclear proteins rapidly stimulated by DNA damage. Its homeostasis is a dynamic process regulated by the synthesizing enzymes poly(ADP-ribose) polymerases (PARPs) and the degrading enzyme poly(ADP-ribose) glycohydrolase (PARG). PARP-1, the first-discovered and major PARP, has been the focus of many studies aimed at clarifying the biological function of poly(ADP-ribose) (PAR). This abundant nuclear enzyme plays key roles in a variety of cellular processes, including the regulation of chromatin structure, tran

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17

Coyle, Donna L. (Donna Lynn). "Modification of Cardiac Membrane Gsα by an Endogenous Arginine-Specific Mono-Adp-Ribosyltransferase". Thesis, University of North Texas, 1993. https://digital.library.unt.edu/ark:/67531/metadc332726/.

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The mechanism by which nicotinamide adenine dinucleotide (NAD) stimulates the activity of adenylate cyclase (AC) in canine plasma membrane has been studied. Using [3 2P]-NAD, the activation by NAD was correlated with the radiolabeling of the stimulatory guanosine triphosphate (GTP) binding protein Gsa. Further characterization demonstrated that the modification occurred only in the presence of G-protein activators and that arginine residue(s) were modified by ADP-ribose by the action of a mono-ADP-ribosyltransferase. Inhibitors of the transferase blocked both the modification of Gsa and the ac

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18

Peters, Jeffery. "Effects of Nicotinamide Riboside and Beta-hydroxybutyrate on C. elegans Lifespan." Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/honors/531.

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The nicotinamide riboside (NR) form of vitamin B3and the ketone body ß-hydroxybutyrate (BHB) are two of the most promising natural compounds yet identified for the treatment of aging and aging-related diseases. Forms of vitamin B3are precursors for the synthesis of the coenzymes nicotinamide adenine dinucleotide (NAD(H)) and nicotinamide adenine dinucleotide phosphate (NADP(H)). In aged cells levels of NAD+decline, decreasing metabolism and decreasing activity of protective sirtuin protein deacetylases. In aged cells NR, but not more common forms of vitamin B3, boost NAD+levels. BHB is natural

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19

Wos, Melissa Louise, and n/a. "Methods For Understanding Bacterial Metabolic Activity In Activated Sludge." Griffith University. School of Environmental Engineering, 2005. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20061031.151641.

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Biological wastewater treatment relies on the diverse and complex metabolic activities of bacteria to remove pollutants. Its success depends on the metabolic efficiency of the bacteria. Activated sludge models use parameters that attempt to depict bacterial growth and metabolic processes. However, current methods do not separate metabolic activity from growth and maintenance. As a result, activated sludge processes are misinterpreted or over-simplified. Alternative methods for gauging bacterial activity have been proposed and include the measurements of cellular derived compounds that relate s

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Wos, Melissa Louise. "Methods For Understanding Bacterial Metabolic Activity In Activated Sludge." Thesis, Griffith University, 2005. http://hdl.handle.net/10072/367303.

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Biological wastewater treatment relies on the diverse and complex metabolic activities of bacteria to remove pollutants. Its success depends on the metabolic efficiency of the bacteria. Activated sludge models use parameters that attempt to depict bacterial growth and metabolic processes. However, current methods do not separate metabolic activity from growth and maintenance. As a result, activated sludge processes are misinterpreted or over-simplified. Alternative methods for gauging bacterial activity have been proposed and include the measurements of cellular derived compounds that relate s

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21

Peres-Lascar, Audrey. "Etude des mécanismes moléculaires de la cross présentation antigénique dans les sous populations de cellules dendritiques conventionnelles murines." Paris 6, 2009. http://www.theses.fr/2009PA066095.

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Les cellules dendritiques (DC) sont des cellules présentatrices de l’antigène. Quand la DC présente un antigène exogène sur les molécules du CMH-I et active un lymphocyte T CD8+, on parle de cross présentation de l’antigène. Nous savons que seules les DC CD8+ (CD8+) cross présentent de manière efficace les antigènes. Les DC ont une adaptation de leur voie de phagocytose leur permettant une dégradation partielle des antigènes par les protéases lysosomales. Ainsi la NADPH oxydase est recrutée à la membrane des phagosomes précoces de DC ne produisant que de faible quantité de dérivés oxygénés res

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22

Sidhu, Navdeep Singh. "Crystal Structures of a Bacterial Isocitrate Dehydrogenase and the Human Sulfamidase." Doctoral thesis, Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2014. http://hdl.handle.net/11858/00-1735-0000-0015-A383-5.

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23

Fang, Lei. "Development and Characterization of an Iridium-Modified Electrochemical Biosensor for Potential Diabetic Patient Management." Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1223049333.

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Thesis (Ph.D.)--Case Western Reserve University, 2008<br>Department of Chemical Engineering Abstract Title from OhioLINK abstract screen (viewed on 10 April 2009) Available online via the OhioLINK ETD Center

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24

UMMARINO, SIMONE. "Quantificazione della Nicotinamide Riboside e dei suoi precursori NMN e NAD nel latte mediante un nuovo saggio enzimatico fluorimetrico." Doctoral thesis, Università Politecnica delle Marche, 2017. http://hdl.handle.net/11566/245456.

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QUANTIFICAZIONE DELLA NICOTINAMIDE RIBOSIDE E DEI SUOI PRECURSORI NMN E NAD NEL LATTE, MEDIANTE UN NUOVO SAGGIO ENZIMATICO FLUORIMETRICO. La Nicotinammide Riboside (NR), è una forma della vitamina B3 che può essere assunta come tale con la dieta o può derivare dalla digestione del NAD (Nicotinammide Adenin Dinucleotide) e/o dell’NMN (Nicotinammide Mononucleotide) ad opera degli enzimi della flora o della mucosa intestinale. Una volta assorbita, la vitamina viene convertita a NAD, che ne rappresenta la forma biologicamente attiva. Studi recenti hanno dimostrano che la somministrazione di NR e

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25

Chaves, Izabel de Souza. "Efeitos fisiológicos da expressão reduzida de transportadores de NAD + em Arabidopsis thaliana." Universidade Federal de Viçosa, 2015. http://www.locus.ufv.br/handle/123456789/8357.

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Submitted by Marco Antônio de Ramos Chagas (mchagas@ufv.br) on 2016-08-18T13:12:26Z No. of bitstreams: 1 texto completo.pdf: 3202297 bytes, checksum: ff58b805bac6e6441873e70ad76878b4 (MD5)<br>Made available in DSpace on 2016-08-18T13:12:26Z (GMT). No. of bitstreams: 1 texto completo.pdf: 3202297 bytes, checksum: ff58b805bac6e6441873e70ad76878b4 (MD5) Previous issue date: 2015-07-16<br>Fundação de Amparo à Pesquisa do Estado de Minas Gerais<br>Nicotinamida adenina dinucleotídeo (NAD + ) e seu derivado NADP + são compostos essenciais em todos os organismos vivos e que estão envolvidos em t

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26

Hentschke, Mike-Percy [Verfasser]. "Prüfung der parenteralen und enteralen Bioverfügbarkeit von reduziertem Nicotinamid-adenin-dinucleotid (NADH) im ZNS der narkotisierten Ratte mittels Laser-induzierter Fluoreszenzspektroskopie / Mike-Percy Hentschke." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2010. http://d-nb.info/1024006859/34.

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Porpino, Suênia Karla Pacheco. "Nitrato orgânico 2-nitrato-1,3-dibutoxipropano (NDBP) atenua o estresse oxidativo e a hipertensão arterial mediada por angiotensina II via produção de óxido nítrico em animais experimentais." Universidade Federal da Paraíba, 2016. http://tede.biblioteca.ufpb.br:8080/handle/tede/9694.

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Submitted by FABIANA DA SILVA FRANÇA (fabiana21franca@gmail.com) on 2017-11-09T16:00:06Z No. of bitstreams: 2 arquivototal.pdf: 6569210 bytes, checksum: e5c8caef20052f8926c2763bec055f88 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)<br>Made available in DSpace on 2017-11-09T16:00:06Z (GMT). No. of bitstreams: 2 arquivototal.pdf: 6569210 bytes, checksum: e5c8caef20052f8926c2763bec055f88 (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2016-02-22<br>Background: Nitric oxide (NO) donors can act in the control

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Noriega, Esteban Núria. "The Rtg1 and Rtg3 proteins are novel transcription factors regulated by the yeast hog1 mapk upon osmotic stress." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7158.

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La adaptación de la levadura Saccharomyces cerevisiae a condiciones de alta osmolaridad está mediada por la vía de HOG ((high-osmolarity glycerol). La activación de esta vía induce una serie de respuestas que van a permitir la supervivencia celular en respuesta a estrés. La regulación génica constituye una respuesta clave para dicha supervivencia. Se han descrito cinco factores de transcripción regulados por Hog1 en respuesta a estrés osmótico. Sin embargo, éstos no pueden explicar la totalidad de los genes regulados por la MAPK Hog1. En el presente trabajo describimos cómo el complejo transcr

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Vendrell, Arasa Alexandre. "SCF cdc4 regulates msn2 and msn4 dependent gene expression to counteract hog1 induced lethality." Doctoral thesis, Universitat Pompeu Fabra, 2009. http://hdl.handle.net/10803/7153.

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L'activació sostinguda de Hog1 porta a una inhibició del creixement cel·lular. En aquest treball, hem observat que el fenotip de letalitat causat per l'activació sostinguda de Hog1 és parcialment inhibida per la mutació del complexe SCFCDC4. La inhibició de la mort causada per l'activació sostinguda de Hog1 depèn de la via d'extensió de la vida. Quan Hog1 s'activa de manera sostinguda, la mutació al complexe SCFCDC4 fa que augmenti l'expressió gènica depenent de Msn2 i Msn4 que condueix a una sobreexpressió del gen PNC1 i a una hiperactivació de la deacetilassa Sir2. La hiperactivació de Sir2

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30

Tompson-Mennitz, A. "A pilot longitudinal examination of biomarkers and social cognition in Multiple Sclerosis." Thesis, 2022. https://eprints.utas.edu.au/47642/.

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Social-cognitive difficulties in Multiple Sclerosis (MS) have devastating psychosocial impacts, yet assessment is challenging and treatments scarce. This pilot longitudinal study examined the potential role of inflammatory cytokines and nicotinamide adenine dinucleotide (NAD+) as predictive biomarkers of social-cognitive abilities in people with MS (pwMS). Seventeen pwMS (13 female, 18-62 years old) provided blood samples and were assessed for the social-cognitive domains of emotion recognition and sarcasm detection tapping into Theory of Mind, using The Awareness of Social Inference Test-Shor

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31

Chen, meiyau, and 陳媺媱. "Nicotinamide Adenine Dinucleotide Plays A Crucial Role In Calorie Restriction Extended Replicative Lifespan Of Human Hs68 Cells." Thesis, 2012. http://ndltd.ncl.edu.tw/handle/97047196245229528678.

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碩士<br>中州科技大學<br>保健食品系<br>100<br>Caloric restriction (CR) can extend the lifespan of organisms. Nicotinamide adenine dinucleotide (NAD+) is one of bioactive from of vitamin B3. Sirtuins is a protein family called NAD+-dependent deacetylase, which is considered as a longevity protein. FK866 is an inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), which is the rate limiting enzyme in the salvage pathway of NAD+ synthesis from nicotinamide and has ability to decrease intracellular NAD+ level. In this study, we examined whether CR can increase intracellular NAD+ levels, and then activate

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Weeks, Martha Lee. "Design of a reagentless enzymatic amperometric alcohol biosensor yeast alcohol dehydrogenase and nicotinamide adenine dinucleotide on vertically aligned carbon nanofibers /." 2006. http://etd.utk.edu/2006/WeeksMartha.pdf.

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Tamsett, Thomas J. "Sodium activated potassium channels (K(Na)) are modulated by nicotinamide adenine dinucleotide (NAD+) in adult dorsal root ganglion (DRG) neurons." 2008. http://proquest.umi.com/pqdweb?did=1588771761&sid=17&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (M.S.)--State University of New York at Buffalo, 2008.<br>Title from PDF title page (viewed on Feb. 12, 2009) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Bhattacharjee, Arin, Slaughter, Malcolm Includes bibliographical references.

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Guo, Han Wen, and 郭瀚文. "Detection of Metabolic Changes during Osteogenic Differentiation of Human Mesenchymal Stem Cells by Fluorescence Lifetime Changes of Reduced Nicotinamide Adenine Dinucleotide (NADH)." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/49539012464348170065.

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碩士<br>國立陽明大學<br>生醫光電工程研究所<br>96<br>Stem cells have been demonstrated having potential applications in tissue engineering and regenerative medicine. One of the known metabolic properties of stem cell is the change of metabolic switch from stem cells to differential state. The metabolic shift is form anaerobic glycolysis to the more efficient mitochondrial oxidative metabolism. Base on this property of stem cell, we observed the lifetime of reduced nicotinamide adenine dinucleotide (NADH) via two-photon Fluorescence lifetime imaging microscopy (FLIM) during osteogenic differentiation of human me

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