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Journal articles on the topic 'Nicotinamide dehydrogenase subunit 4'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Kumari, Shesh, and Angela Di Cesare. "Nicotinamide dehydrogenase subunit 4 analysis of Xiphinema diversicaudatum and Xiphinema simile (Nematoda: Longidoridae)." European Journal of Plant Pathology 136, no. 4 (2013): 803–10. http://dx.doi.org/10.1007/s10658-013-0208-5.

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Mariotto, Sandra, Mari Rose Oliveira Silva, Cristina Márcia de Menezes Butakka, et al. "Comparative Genetics Using Three mtDNA Markers in Aedes aegypti (Linnaeus) Populations from Municipalities in the State of Mato Grosso, Brazil." Ensino, Saude e Ambiente 15, no. 3 (2023): 503–23. http://dx.doi.org/10.22409/resa2022.v15i3.a54219.

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A methodological strategy for teaching in health and environment is to know the genetics of an important vector of dengue in different populations of mosquitoes. The aim of this study was to investigate the genetic variability of Aedes aegypti through molecular markers of mitochondrial DNA, COI, ND4 and ND5. Mosquitoes were collected using ovitraps to capture them at points located in four municipalities in the state of Mato Grosso. Subsequently, we amplified 169 samples with the best DNA result using primers for mitochondrial DNA (mtDNA): Cytochrome Oxidase Subunit I (COI - F and R), Nicotina

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Dahadhah, Fatina W., Mayyas Saleh Jaweesh, Mazhar Salim Al Zoubi, Manal Issam Abu Alarjah, Mohamad Eid Hammadeh, and Houda Amor. "Mitochondrial nicotinamide adenine dinucleotide hydride dehydrogenase (NADH) subunit 4 (MTND4) polymorphisms and their association with male infertility." Journal of Assisted Reproduction and Genetics 38, no. 8 (2021): 2021–29. http://dx.doi.org/10.1007/s10815-021-02199-w.

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Abstract Purpose The purpose of the present study was to determine the relationship between infertility and the polymorphisms of mitochondrial NADH dehydrogenase subunit 4 (MTND4) by spermatozoa analysis in fertile and subfertile men. Methods Samples were divided into 68 subfertile men (case group) and 44 fertile men (control group). After semen analysis, samples were purified. The whole genome was extracted using a QIAamp DNA Mini Kit and the mitochondrial DNA was amplified by using the REPLI-g Mitochondrial DNA Kit. Polymerase chain reaction (PCR) was used to amplify the MT-ND4 gene. Then, s

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Dunham-Snary, Kimberly J., Danchen Wu, François Potus, et al. "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction." Circulation Research 124, no. 12 (2019): 1727–46. http://dx.doi.org/10.1161/circresaha.118.314284.

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Rationale: Hypoxic pulmonary vasoconstriction (HPV) optimizes systemic oxygen delivery by matching ventilation to perfusion. HPV is intrinsic to pulmonary artery smooth muscle cells (PASMCs). Hypoxia dilates systemic arteries, including renal arteries. Hypoxia is sensed by changes in mitochondrial-derived reactive oxygen species, notably hydrogen peroxide (H 2 O 2 ) ([H 2 O 2 ] mito ). Decreases in [H 2 O 2 ] mito elevate pulmonary vascular tone by increasing intracellular calcium ([Ca 2+ ] i ) through reduction-oxidation regulation of ion channels. Although HPV is mimicked by the Complex I in

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Parsons, Richard B., Shylesh Aravindan, Anusha Kadampeswaran, et al. "The expression of nicotinamide N-methyltransferase increases ATP synthesis and protects SH-SY5Y neuroblastoma cells against the toxicity of Complex I inhibitors." Biochemical Journal 436, no. 1 (2011): 145–55. http://dx.doi.org/10.1042/bj20101685.

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NNMT (nicotinamide N-methyltransferase, E.C. 2.1.1.1) catalyses the N-methylation of nicotinamide to 1-methylnicotinamide. NNMT expression is significantly elevated in a number of cancers, and we have previously demonstrated that NNMT expression is significantly increased in the brains of patients who have died of Parkinson's disease. To investigate the cellular effects of NNMT overexpression, we overexpressed NNMT in the SH-SY5Y cell line, a tumour-derived human dopaminergic neuroblastoma cell line with no endogenous expression of NNMT. NNMT expression significantly decreased SH-SY5Y cell dea

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Nishino, Daichi, Taketo Haginouchi, Takeshi Shimogiri, et al. "A Pilot Study: Maternal Undernutrition Programs Energy Metabolism and Alters Metabolic Profile and Morphological Characteristics of Skeletal Muscle in Postnatal Beef Cattle." Metabolites 15, no. 3 (2025): 209. https://doi.org/10.3390/metabo15030209.

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Objectives: This study investigated the long-term effects of maternal undernutrition on overall muscle metabolism, growth performance, and muscle characteristics in postnatal offspring of Wagyu (Japanese Black) cattle. Methods: Wagyu cows were divided into nutrient-adequate (control, CNT; n = 4, 120% of requirements) and nutrient-restricted groups (NR; n = 4; 60% of requirements), and treated from day 35 of gestation until parturition. Diets were delivered on the basis of crude protein requirements, meeting 100% and 80% of dry matter requirements in CNT and NR groups, respectively. All offspri

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7

Hussain, Shafaat, Abdul Waheed Khan, Alexander Akhmedov, et al. "Hyperglycemia Induces Myocardial Dysfunction via Epigenetic Regulation of JunD." Circulation Research 127, no. 10 (2020): 1261–73. http://dx.doi.org/10.1161/circresaha.120.317132.

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Rationale: Hyperglycemia -induced reactive oxygen species are key mediators of cardiac dysfunction. JunD (Jund proto-oncogene subunit), a member of the AP-1 (activator protein-1) family of transcription factors, is emerging as a major gatekeeper against oxidative stress. However, its contribution to redox state and inflammation in the diabetic heart remains to be elucidated. Objective: The present study investigates the role of JunD in hyperglycemia-induced and reactive oxygen species–driven myocardial dysfunction. Methods and Results: JunD mRNA and protein expression were reduced in the myoca

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Chen, Sixi, Xinzhu Bao, Hongzhi Chen, et al. "Thyroid Cancer-Associated Mitochondrial DNA Mutation G3842A Promotes Tumorigenicity via ROS-Mediated ERK1/2 Activation." Oxidative Medicine and Cellular Longevity 2022 (March 15, 2022): 1–16. http://dx.doi.org/10.1155/2022/9982449.

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Mitochondrial DNA (mtDNA) mutations have been identified in various human cancers, including thyroid cancer. However, the relationship between mtDNA and thyroid cancer remains unclear. Previous studies by others and us strongly suggested that mtDNA mutations in complex I may participate in thyroid cancer processes according to sequencing results of thyroid cancer tissue, although the associated pathogenic processes remain unknown. Here, to investigate whether mtDNA mutations contribute to thyroid cancer, we reanalyzed our sequencing results and characterized thyroid cancer-associated mutations

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Song, Hao, Xin Dang, Yuan-qiu He, Tao Zhang, and Hai-yan Wang. "Selection of housekeeping genes as internal controls for quantitative RT-PCR analysis of the veined rapa whelk (Rapana venosa)." PeerJ 5 (May 31, 2017): e3398. http://dx.doi.org/10.7717/peerj.3398.

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BackgroundThe veined rapa whelkRapana venosais an important commercial shellfish in China and quantitative real-time PCR (qRT-PCR) has become the standard method to study gene expression inR. venosa. For accurate and reliable gene expression results, qRT-PCR assays require housekeeping genes as internal controls, which display highly uniform expression in different tissues or stages of development. However, to date no studies have validated housekeeping genes inR. venosafor use as internal controls for qRT-PCR.MethodsIn this study, we selected the following 13 candidate genes for suitability a

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Cameron, Emilie C., Richard C. Wilkerson, Motoyoshi Mogi, et al. "Molecular Phylogenetics of Aedes japonicus, a Disease Vector That Recently Invaded Western Europe, North America, and the Hawaiian Islands." Journal of Medical Entomology 47, no. 4 (2010): 527–35. http://dx.doi.org/10.1093/jmedent/47.4.527.

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Abstract We used two mitochondrial loci (nicotinamide adenine dinucleotide dehydrogenase subunit 4 and cytochrome oxidase II) and a nuclear locus (28S-D2 spacer) for a total of 1337 bp to evaluate the relationships among the four subspecies of Aedes (Finlaya) japonicus Theobald. Ae. j. japonicus was recently introduced into the United States and has been expanding rapidly. We also included in our analysis a morphologically very closely related species, Aedes (Finlaya) koreicus Edwards, as well as three more distantly related species: Aedes (Finlaya) togoi Theobald, Aedes (Finlaya) hatorii Yama

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Peng, Zehong, Xin Liu, Xi Zhu, et al. "Exploration of the effects of 66 mitochondria-associated proteins on different cardiomyopathies: A bidirectional 2-sample mendelian randomization study." Medicine 104, no. 22 (2025): e42556. https://doi.org/10.1097/md.0000000000042556.

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The aim of this study was to apply bidirectional Mendelian randomization (MR) to assess and investigate the causal associations between mitochondrial DNA copy number (mtDNA-CN), mitochondrial-associated proteins and cardiomyopathy. The mtDNA-CN and MAP from the IEU Open GWAS database were screened for strong associations with 4 different cardiomyopathy-associated single nucleotide polymorphisms (SNPs) in the IEU Open GWAS and Finnish databases, respectively, and causal associations were investigated using the inverse variance weighting method, the MR-Egger regression method, the weighted media

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Kokaze, Akatsuki, Mamoru Ishikawa, Naomi Matsunaga, et al. "NADH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Influences the Association of Coffee Consumption with Serum Chloride Levels in Male Japanese Health Checkup Examinees: An Exploratory Cross-Sectional Analysis." Nutrients 10, no. 10 (2018): 1344. http://dx.doi.org/10.3390/nu10101344.

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Background: Nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism has been shown to modify the association of coffee consumption with the risk of hypertension, dyslipidemia, and abnormal glucose tolerance, and low serum chloride levels have been shown to be associated with all-cause and cardiovascular disease mortality. Therefore, the purpose of the present study was to investigate whether ND2-237 Leu/Met polymorphism influences the association of coffee consumption with serum chloride levels in male Japanese health checkup exami

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Lazarova, Stela, Vlada Peneva, and Shesh Kumari. "Morphological and molecular characterisation, and phylogenetic position of X. browni sp. n., X. penevi sp. n. and two known species of Xiphinema americanum-group (Nematoda, Longidoridae)." ZooKeys 574 (March 28, 2016): 1–42. https://doi.org/10.3897/zookeys.574.8037.

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Using ribosomal (18S, ITS1, ITS2, D2-D3 expansion segments of 28S rDNA) and mitochondrial (partial cox1 and nad4) DNA markers in a study of several populations of Xiphinema americanum-group from Europe and Morocco, two cryptic species X. browni sp. n. (formerly reported as X. pachtaicum) and X. penevi sp. n. were revealed. The species are described, illustrated and their phylogenetic relationships discussed. The first species is most similar to X. parasimile and is a member of X. simile species complex. The phylogenetic reconstructions inferred from three molecular markers (18S, D2-D3 28S rDNA

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Arsenopoulos, Konstantinos V., Styliani Minoudi, Isaia Symeonidou, Alexandros Triantafyllidis, George C. Fthenakis, and Elias Papadopoulos. "Extensive Countrywide Molecular Identification and High Genetic Diversity of Haemonchus spp. in Domestic Ruminants in Greece." Pathogens 13, no. 3 (2024): 238. http://dx.doi.org/10.3390/pathogens13030238.

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The gastrointestinal nematode parasite Haemonchus spp. is one of the most pathogenic parasites of ruminants, due to its blood-sucking activity, which causes large economic losses in the ruminant industry. The latest epizootiological data recorded an increase in the infection, not only in Greece but also in other countries, mainly attributed to climatic changes. The study of the population structure and the investigation of the phylogenetic relationships of Haemonchus spp. are essential for the understanding of its biology and epizootiology to implement appropriate control and prevention strate

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Jin, Qing, Jibao Jiang, Jiali Li, and Jiangping Qiu. "Population Genetic Structure and Diversity of Metaphire remanens (Oligochaeta: Megascolecidae) Based on Mitochondrial DNA Analysis, with a Note on a New Species of Metaphire remanens sp. nov." Diversity 14, no. 4 (2022): 275. http://dx.doi.org/10.3390/d14040275.

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Metaphire remanens sp. nov. is widely distributed throughout Hunan Province, China. We sequenced the mitochondrial DNA to investigate its population genetic structure and genetic diversity, including cytochrome c oxidase subunit I, cytochrome c oxidase subunit II, 12S ribosomal (r)RNA, 16S rRNA, and nicotinamide adenine dinucleotide dehydrogenase subunit 1, derived from 39 individuals from seven geographic locations in Hunan Province. The genetic diversity indices showed that populations of M. remanens have a strong genetic structure and obvious dispersal histories. M. remanens did not experie

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Osborne, M. J., and L. Christidis. "Molecular relationships of the cuscuses, brushtail and scaly-tailed possums (Phalangerinae)." Australian Journal of Zoology 50, no. 2 (2002): 135. http://dx.doi.org/10.1071/zo01070.

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DNA sequence data (1040 base pairs) from the mitochondrial nicotinamide dehydrogenase subunit 2 gene (ND2) was used to elucidate species relationships within the Phalangerinae (cuscuses, brushtail and scaly-tailed possums). Phylogenetic analyses revealed three lineages within this family (Spilocuscus, Phalanger and Trichosurus-Wyulda), which is congruent with the results of other molecular studies. Sequence data also demonstrate that P. orientalis, P. carmelitae, P. vestitus, and P. sericeus are closely related and indicates that P. gymnotis is the sister lineage to the genus Phalanger. Diverg

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SADASIVAN, KALESH, M. B. RAMESH, MUHAMED JAFER PALOT, MAYURESH AMBEKAR, and ZEESHAN A. MIRZA. "A new species of fan-throated lizard of the genus Sitana Cuvier, 1829 from coastal Kerala, southern India." Zootaxa 4374, no. 4 (2018): 545. http://dx.doi.org/10.11646/zootaxa.4374.4.5.

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We here describe Sitana attenboroughii sp. nov., a new species of fan-throated lizard of the genus Sitana Cuvier, 1829 from coastal Kerala in southern India. The new species morphologically is closer to Sitana visiri Deepak, 2016 (in Deepak et al. 2016a), however, differs in having higher numbers of ventral scales and a comparatively short but richly colored dewlap. Genetically the new species shows affinity to Sitana marudhamneydhal Deepak, Khandekar, Varma & Chaitanya, 2016 from which it differs in an uncorrected pairwise sequence divergence of 2.2% for a fragment of mitochondrial Nicoti

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18

Kumar, Hemant, and Silke Leimkühler. "Changing the Electron Acceptor Specificity of Rhodobacter capsulatus Formate Dehydrogenase from NAD+ to NADP+." International Journal of Molecular Sciences 24, no. 22 (2023): 16067. http://dx.doi.org/10.3390/ijms242216067.

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Formate dehydrogenases catalyze the reversible oxidation of formate to carbon dioxide. These enzymes play an important role in CO2 reduction and serve as nicotinamide cofactor recycling enzymes. More recently, the CO2-reducing activity of formate dehydrogenases, especially metal-containing formate dehydrogenases, has been further explored for efficient atmospheric CO2 capture. Here, we investigate the nicotinamide binding site of formate dehydrogenase from Rhodobacter capsulatus for its specificity toward NAD+ vs. NADP+ reduction. Starting from the NAD+-specific wild-type RcFDH, key residues w

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Tsai, C. Stan, and Q. Chen. "Purification and kinetic characterization of 6-phosphogluconate dehydrogenase from Schizosaccharomyces pombe." Biochemistry and Cell Biology 76, no. 4 (1998): 637–44. http://dx.doi.org/10.1139/o98-083.

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6-Phosphogluconate dehydrogenase is the pivotal enzyme that links the gluconate route and the oxidative phase of the pentose phosphate pathway in Schizosaccharomyces pombe. The enzyme differs from the known 6-phosphogluconate dehydrogenases of other sources in that the Schizosaccharomyces enzyme is tetrameric having a subunit mass of 38 kDa, that it requires NADP+ obligatorily for activity, and that it can be activated by divalent metal ions such as Co2+ and Mn2+. Steady-state kinetic studies were undertaken. Initial rate and product inhibition results suggest that 6-phosphogluconate dehydroge

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Kozlu, Tolunay, Fatma Güler, Pınar Peker Akalın, Filiz Kazak, Yaşar Ergün, and Erdoğan Aslan. "The influence of Theranekron® on glucose-6-phosphate dehydrogenase activity in rat ovaries, intact and with ischemia-reperfusion injury." Veterinarski arhiv 91, no. 1 (2021): 81–88. http://dx.doi.org/10.24099/vet.arhiv.0828.

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The effect of Theranekron® on rat ovaries was evaluated in healthy and ischemia-reperfusion injury models. The rats were divided into four groups: group 1: control, group 2: Theranekron® (single dose of 0.3 mg/kg intraperitoneally), group 3: torsion + detorsion, and group 4: torsion + detorsion + Theranekron® (single dose 0,3 mg/kg, intraperitoneally). The ovaries were homogenized by sonication before the analysis and supernatant glucose-6-phosphate dehydrogenase activity, reduced nicotinamide adenine dinucleotide phosphate, reduced glutathione and total protein levels were evaluated spectroph

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Johnson, Hope A., Dale A. Pelletier, and Alfred M. Spormann. "Isolation and Characterization of Anaerobic Ethylbenzene Dehydrogenase, a Novel Mo-Fe-S Enzyme." Journal of Bacteriology 183, no. 15 (2001): 4536–42. http://dx.doi.org/10.1128/jb.183.15.4536-4542.2001.

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ABSTRACT The first step in anaerobic ethylbenzene mineralization in denitrifying Azoarcus sp. strain EB1 is the oxidation of ethylbenzene to (S)-(−)-1-phenylethanol. Ethylbenzene dehydrogenase, which catalyzes this reaction, is a unique enzyme in that it mediates the stereoselective hydroxylation of an aromatic hydrocarbon in the absence of molecular oxygen. We purified ethylbenzene dehydrogenase to apparent homogeneity and showed that the enzyme is a heterotrimer (αβγ) with subunit masses of 100 kDa (α), 35 kDa (β), and 25 kDa (γ). Purified ethylbenzene dehydrogenase contains approximately 0.

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Joukyuu, R., S. Mizuno, T. Amakawa, T. Tsukada, T. Nishina, and M. Kitamura. "Hereditary complete deficiency of lactate dehydrogenase H-subunit." Clinical Chemistry 35, no. 4 (1989): 687–90. http://dx.doi.org/10.1093/clinchem/35.4.687.

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Abstract We report the second known case of a patient, a 45-year-old Japanese woman, with hereditary complete deficiency of lactate dehydrogenase (LDH; EC 1.1.1.27) H-subunit. Total LDH activity in her serum was abnormally low (35 U/L, normal reference interval 195-360). LDH activity in her erythrocytes was also low, but all the other glycolytic enzyme activities in her erythrocytes were within normal limits. Electrophoresis of her serum, erythrocytes, lymphocytes, thrombocytes, and saliva showed only one band, the LDH M4 isoenzyme. LDH activities in her saliva and lymphocytes exceeded the ref

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Zeng, Y., C. Weiss, T. T. Yao, et al. "Isocitrate dehydrogenase from bovine heart: primary structure of subunit 3/4." Biochemical Journal 310, no. 2 (1995): 507–16. http://dx.doi.org/10.1042/bj3100507.

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Bovine NAD(+)-dependent isocitrate dehydrogenase was shown previously to contain four subunits of approx. 40 kDa (subunits 1-4) possessing different peptide maps and electrophoretic properties [Rushbrook and Harvey (1978) Biochemistry 17, 5339-5346]. In this study the heterogeneity is confirmed using enzyme purified by updated methods and from single animals, ruling out allelic variability. Subunits 1 and 2 were differentiated from each other and from subunits 3 and 4 by N-terminal amino acid sequencing. Subunits 3 and 4 (subunits 3/4) were identical in sequence over 30 residues. The N-termina

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van Straaten, Karin E., Hongyan Zheng, David R. J. Palmer, and David A. R. Sanders. "Structural investigation of myo-inositol dehydrogenase from Bacillus subtilis: implications for catalytic mechanism and inositol dehydrogenase subfamily classification." Biochemical Journal 432, no. 2 (2010): 237–47. http://dx.doi.org/10.1042/bj20101079.

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Inositol dehydrogenase from Bacillus subtilis (BsIDH) is a NAD+-dependent enzyme that catalyses the oxidation of the axial hydroxy group of myo-inositol to form scyllo-inosose. We have determined the crystal structures of wild-type BsIDH and of the inactive K97V mutant in apo-, holo- and ternary complexes with inositol and inosose. BsIDH is a tetramer, with a novel arrangement consisting of two long continuous β-sheets, formed from all four monomers, in which the two central strands are crossed over to form the core of the tetramer. Each subunit in the tetramer consists of two domains: an N-te

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Beltrame, María Ornela, Cesar Pruzzo, Rodrigo Sanabria, Alberto Pérez, and Matías Sebastián Mora. "First report of pre-Hispanic Fasciola hepatica from South America revealed by ancient DNA." Parasitology 147, no. 3 (2019): 371–75. http://dx.doi.org/10.1017/s0031182019001719.

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AbstractIt is generally assumed that the digenean human liver fluke, Fasciola hepatica, gained entry to South America during the 15th century upon arrival of Europeans and their livestock. Nonetheless in Patagonia, Argentina, digenean eggs similar to F. hepatica have been observed in deer coprolites dating back to 2300 years B.P. The main objective of our present study was to identify and characterize these eggs using an ancient DNA (aDNA) study. Eggs were isolated and used for aDNA extraction, amplification and sequencing of partial regions from the cytochrome c oxidase subunit 1 and the nico

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VERMA, ANITA, MANISH K. SUTHAR, PAWAN K. DOHAREY, et al. "Molecular cloning and characterization of glucose-6-phosphate dehydrogenase from Brugia malayi." Parasitology 140, no. 7 (2013): 897–906. http://dx.doi.org/10.1017/s0031182013000115.

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SUMMARYGlucose-6-phosphate dehydrogenase (G6PD), a regulatory enzyme of the pentose phosphate pathway from Brugia malayi, was cloned, expressed and biochemically characterized. The Km values for glucose-6-phosphate and nicotinamide adenine dinucleotide phosphate (NADP) were 0·25 and 0·014 mm respectively. The rBmG6PD exhibited an optimum pH of 8·5 and temperature, 40 °C. Adenosine 5′ [γ-thio] triphosphate (ATP-γ-S), adenosine 5′ [β,γ-imido] triphosphate (ATP-β,γ-NH), adenosine 5′ [β-thio] diphosphate (ADP-β-S), Na+, K+, Li+ and Cu++ ions were found to be strong inhibitors of rBmG6PD. The rBmG6

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Huo, Heyu, Guangxiao Yao, and Shizhen Wang. "Economy Assessment for the Chiral Amine Production with Comparison of Reductive Amination and Transamination Routes by Multi-Enzyme System." Catalysts 10, no. 12 (2020): 1451. http://dx.doi.org/10.3390/catal10121451.

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Chiral amines are key building blocks for pharmaceuticals. Economic assessment of commercial potential of bioprocesses is needed for guiding research. Biosynthesis of (S)-α-methylbenzylamine (MBA) was selected as case study. For transamination route, transaminase coupled with glucose dehydrogenase and lactate dehydrogenase catalyzed the reaction with NADH (Nicotinamide adenine dinucleotide) regeneration. Amine dehydrogenase coupled with NADH oxidase, which catalyzed the reductive amination process. Comparison of biosynthesis cost by reductive amination and transamination routes was carried out

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Picca, Anna, Raffaella Beli, Riccardo Calvani, et al. "Older Adults with Physical Frailty and Sarcopenia Show Increased Levels of Circulating Small Extracellular Vesicles with a Specific Mitochondrial Signature." Cells 9, no. 4 (2020): 973. http://dx.doi.org/10.3390/cells9040973.

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Mitochondrial dysfunction and systemic inflammation are major factors in the development of sarcopenia, but the molecular determinants linking the two mechanisms are only partially understood. The study of extracellular vesicle (EV) trafficking may provide insights into this relationship. Circulating small EVs (sEVs) from serum of 11 older adults with physical frailty and sarcopenia (PF&S) and 10 controls were purified and characterized. Protein levels of three tetraspanins (CD9, CD63, and CD81) and selected mitochondrial markers, including adenosine triphosphate 5A (ATP5A), mitochondrial

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Sled, Vladimir D., and Andrei D. Vinogradov. "Reductive inactivation of the mitochondrial three subunit NADH dehydrogenase." Biochimica et Biophysica Acta (BBA) - Bioenergetics 1143, no. 2 (1993): 199–203. http://dx.doi.org/10.1016/0005-2728(93)90143-4.

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Rajapakse, R. P. V. J., S. P. Lawton, K. J. K. Karunathilake, B. V. P. Perera, N. T. B. Nguyen, and T. H. Le. "Molecular characterization of Fasciola jacksoni from wild elephants (Elephas maximus maximus) of Sri Lanka: a taxonomic evaluation." Parasitology 146, no. 10 (2019): 1247–55. http://dx.doi.org/10.1017/s0031182019000519.

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AbstractFasciola jacksoni is a significant contributor to the health and mortality of Asian elephants, particularly those in Sri Lanka. Despite the impact of fascioliasis on elephant populations, it is a neglected veterinary disease with limited taxonomic understanding. Molecular characterization and phylogenetic analysis of F. jacksoni were carried out to evaluate its suggested basal position in the Fasciolidae. Adult worms were collected during post-mortem of elephants, and eggs were collected from living elephants in National parks across Sri Lanka. Using the mitochondrial genes nicotinamid

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Rojas, A., H. Salant, D. Yasur-Landau, H. Tsarfati, and G. Baneth. "First report of Onchocerca lupi from Israel and confirmation of two genotypes circulating among canine, feline and human hosts." Parasitology 147, no. 14 (2020): 1723–27. http://dx.doi.org/10.1017/s0031182020001560.

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AbstractOnchocerca lupi is a parasitic filarioid and the causative agent of canine ocular onchocercosis, a zoonotic disease of domestic dogs with sporadic reports in humans. A 13-year-old dog with no travel history outside of Israel was presented to an ophthalmology veterinary clinic in Israel with severe right ocular and periocular disease. After surgical exploration, thin helminths were removed from the dorsal sclera of the eye and identified as Onchocerca lupi by polymerase chain reaction according to the cytochrome c oxidase subunit I (cox1), reduced nicotinamide adenine dinucleotide dehyd

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Morgan, Michael A., Birgit Markus, Malou Hermkens, et al. "NADH Dehydrogenase Subunit 4 (ND4) Mutations in Pediatric Acute Myeloid Leukemia." Blood 120, no. 21 (2012): 1380. http://dx.doi.org/10.1182/blood.v120.21.1380.1380.

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Abstract Abstract 1380 NADH dehydrogenase subunit 4 (ND4) is encoded by mitochondrial DNA and is an integral component of Complex I, one of the core enzymatic complexes critical for mitochondrial oxidative phosphorylation and regulation of the balance between NADH and NAD+. ND4 mutations have recently been described in adult acute myeloid leukemia (AML). In the current study, we investigated the frequency and prognostic impact of ND4 mutations in 289 pediatric leukemia patients (&lt;= 18 years). Total cellular DNA was isolated from bone marrow or peripheral blood samples at diagnosis (n=28

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Fernández, Cintia J., Alicia R. Pérez de Rosas, and Beatriz A. García. "Variation in Mitochondrial NADH Dehydrogenase Subunit 5 and NADH Dehydrogenase Subunit 4 Genes in the Chagas Disease Vector Triatoma infestans (Hemiptera: Reduviidae)." American Journal of Tropical Medicine and Hygiene 88, no. 5 (2013): 893–96. http://dx.doi.org/10.4269/ajtmh.12-0451.

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Rutter, G. A., and R. M. Denton. "Regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+ ions within toluene-permeabilized rat heart mitochondria. Interactions with regulation by adenine nucleotides and NADH/NAD+ ratios." Biochemical Journal 252, no. 1 (1988): 181–89. http://dx.doi.org/10.1042/bj2520181.

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1. Toluene-permeabilized rat heart mitochondria have been used to study the regulation of NAD+-linked isocitrate dehydrogenase and 2-oxoglutarate dehydrogenase by Ca2+, adenine and nicotinamide nucleotides, and to compare the properties of the enzymes in situ, with those in mitochondrial extracts. 2. Although K0.5 values (concn. giving half-maximal effect) for Ca2+ of 2-oxoglutarate dehydrogenase were around 1 microM under all conditions, corresponding values for NAD+-linked isocitrate dehydrogenase were in the range 5-43 microM. 3. For both enzymes, K0.5 values for Ca2+ observed in the presen

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Zhang, Li, Wenhui Zhao, Fuping Wang, and Daozheng Qin. "Genetic Diversity and Population Structure of Natural Lycorma delicatula (White) (Hemiptera: Fulgoridea) Populations in China as Revealed by Microsatellite and Mitochondrial Markers." Insects 10, no. 10 (2019): 312. http://dx.doi.org/10.3390/insects10100312.

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The spotted lanternfly, Lycorma delicatula (White) (Hemiptera: Fulgoridae), is a polyphagous pest originating in China and now widely distributed in Asian countries. This is one of the more serious forestry pests with a broad host range and causes significant economic losses. Molecular comparison has been used to investigate this pest’s origin in China, and recent studies have explored the genetic structure among populations in Korea. However, the population structure of this pest in China remains poorly understood. In this study, 13 microsatellite markers and two mitochondrial markers (from n

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BURDETTE, Douglas S., Francesco SECUNDO, Robert S. PHILLIPS, Jun DONG, Robert A. SCOTT, and J. Gregory ZEIKUS. "Biophysical and mutagenic analysis of Thermoanaerobacter ethanolicus secondary-alcohol dehydrogenase activity and specificity." Biochemical Journal 326, no. 3 (1997): 717–24. http://dx.doi.org/10.1042/bj3260717.

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The Thermoanaerobacter ethanolicus 39E adhB gene encoding the secondary-alcohol dehydrogenase (2° ADH) was overexpressed in Escherichia coli at more than 10% of total protein. The recombinant enzyme was purified in high yield (67%) by heat-treatment at 85 °C and (NH4)2SO4 precipitation. Site-directed mutants (C37S, H59N, D150N, D150E and D150C were analysed to test the peptide sequence comparison-based predictions of amino acids responsible for putative catalytic Zn binding. X-ray absorption spectroscopy confirmed the presence of a protein-bound Zn atom with ZnS1(imid)1(N,O)3 co-ordination sph

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Li, Gang, Bing Liang, Yinan Wang, et al. "Echolocation Calls, Diet, and Phylogenetic Relationships of Stoliczka's Trident Bat, Aselliscus stoliczkanus (Hipposideridae)." Journal of Mammalogy 88, no. 3 (2007): 736–44. https://doi.org/10.5281/zenodo.14818082.

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(Uploaded by Plazi for the Bat Literature Project) The comparative biology of the hipposiderid genus Aselliscus has been little studied. Here we report studies of echolocation, diet, and phylogeny of Aselliscus stoliczkanus. The phylogenetic relationships of Aselliscus were investigated based on sequence comparisons of mitochondrial cytochrome-b and nicotinamide adenine dinucleotide dehydrogenase subunit 1 genes. Dates of divergence within the hipposiderid radiation also were estimated. The echolocation call frequency of A. stoliczkanus is quite high, with the dominant constant frequency compo

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James, Keith D., and Peter A. Williams. "ntn Genes Determining the Early Steps in the Divergent Catabolism of 4-Nitrotoluene and Toluene in Pseudomonas sp. Strain TW3." Journal of Bacteriology 180, no. 8 (1998): 2043–49. http://dx.doi.org/10.1128/jb.180.8.2043-2049.1998.

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ABSTRACT Pseudomonas sp. strain TW3 is able to oxidatively metabolize 4-nitrotoluene and toluene via a route analogous to the upper pathway of the TOL plasmids. We report the sequence and organization of five genes, ntnWCMAB*, which are very similar to and in the same order as the xyl operon of TOL plasmid pWW0 and present evidence that they encode enzymes which are expressed during growth on both 4-nitrotoluene and toluene and are responsible for their oxidation to 4-nitrobenzoate and benzoate, respectively. These genes encode an alcohol dehydrogenase homolog (ntnW), an NAD+-linked benzaldehy

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Henniger, Guenther, and Leonard Mascaro. "Enzymatic-Ultraviolet Determination of L-Citric Acid in Wine: Collaborative Study." Journal of AOAC INTERNATIONAL 68, no. 5 (1985): 1024–27. http://dx.doi.org/10.1093/jaoac/68.5.1024.

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Abstract A collaborative study was carried out on an enzymatic method for the determination of L-citric acid in wine, using the enzymes citrate lyase, malate dehydrogenase, and lactate dehydrogenase and the coenzyme nicotinamide-adenine dinucleotide phosphate. The study was performed by 18 laboratories using 4 blind duplicates of commercial wine. The method is simple and shows good precision. Coefficients of variation (CV) for reproducibility ranged from 1.8 to 3.4%; CVs for repeatability ranged from 0.76 to 2.62%. Analysts are cautioned to check the linear absorbance response of their spectop

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40

Sirvid, Philip J., Nicole E. Moore, Geoffrey K. Chambers, and Kelly Prendergast. "A preliminary molecular analysis of phylogenetic and biogeographic relationships of New Zealand Thomisidae (Araneae) using a multi-locus approach." Invertebrate Systematics 27, no. 6 (2013): 655. http://dx.doi.org/10.1071/is13025.

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We tested competing theories on the origins of the New Zealand fauna using thomisid spiders as a model group. These theories can be broadly described as old and vicariant versus young and recent (dispersal). To test these theories, a phylogenetic analysis was undertaken based on cytochrome c oxidase subunit I (COI) and 28S rRNA sequence data, with smaller datasets (histone H3, nicotinamide adenine dinucleotide (NADH) dehydrogenase subunit 1 and a combined dataset) used to improve resolution of internal branches. The monophyly of New Zealand thomisid subfamilies and of individual taxa were also

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van Staden, Michaela, David A. Ebert, Enrico Gennari, et al. "Molecular Taxonomy of South Africa’s Catsharks: How Far Have We Come?" Diversity 15, no. 7 (2023): 828. http://dx.doi.org/10.3390/d15070828.

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The ability to correctly identify specimens at the species level is crucial for assessing and conserving biodiversity. Despite this, species-specific data are lacking for many of South Africa’s catsharks due to a high level of morphological stasis. As comprehensive and curated DNA reference libraries are required for the reliable identification of specimens from morphologically similar species, this study reviewed and contributed to the availability of cytochrome c oxidase subunit I (COI) and nicotinamide adenine dehydrogenase subunit 2 (NADH2) sequences for South Africa’s catsharks. A molecul

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Fussey, Shelley P. M., Shauna M. West, J. Gordon Lindsay, et al. "Clarification of the identity of the major M2 autoantigen in primary biliary cirrhosis." Clinical Science 80, no. 5 (1991): 451–55. http://dx.doi.org/10.1042/cs0800451.

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1. In primary biliary cirrhosis, the major M2 autoantigen, reacting with antimitochondrial antibodies in sera from >90% of patients, has been identified as the E2 component of the pyruvate dehydrogenase complex. However, two recent reports suggest that alternative polypeptides may be major autoantigens. 2. The evidence that a 75 kDa subunit of complex I of the respiratory chain is a major autoantigen (Frostell, Mendel-Hartvig, Nelson, Totterman, Bjorkland & Ragan, Scand. J. Immunol. 1988; 28, 157–65) is refuted. The findings of Frostell et al. can be explained by contamination of comple

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Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and its molecular relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13457197.

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(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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44

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and Its Molecular Relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13519763.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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45

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and its molecular relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13457197.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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46

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and Its Molecular Relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13519763.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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47

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and its molecular relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13457197.

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Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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48

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and Its Molecular Relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13519763.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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49

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and its molecular relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13457197.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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50

Han, Nai-Jian, Jin-Shuo Zhang, Terry Reardon, Liang-Kong Lin, Jun-Peng Zhang, and Shu-Yi Zhang. "Revalidation of Myotis taiwanensis Ärnbäck-Christie-Linde 1908 and Its Molecular Relationship with M. adversus (Horsfield 1824) (Vespertilionidae, Chiroptera)." Acta Chiropterologica 12, no. 2 (2010): 449–56. https://doi.org/10.5281/zenodo.13519763.

Full text

Abstract:

(Uploaded by Plazi for the Bat Literature Project) A combined approach using molecular and morphological data has revealed that the taxon Myotis taiwanensis, which until now has been usually considered as a subspecies of Myotis adversus, should be reinstated as a full species, as originally described by Ärnbäck-Christie-Linde (1908) from Takao, Anping, Tainan, Formosa (= southern Taiwan). In our genetic analysis using two nuclear DNA segments of protein kinase C iota (PRKCI) and ubiquitin specific peptidase 9 (Usp9x), X-linked genes, together with two mitochondrial genes, i.e., nicotinamide ad

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