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1

&NA;. "Nicotine patches." Inpharma Weekly &NA;, no. 1197 (1999): 7. http://dx.doi.org/10.2165/00128413-199911970-00012.

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2

Benowitz, N. L. "Nicotine patches." BMJ 310, no. 6991 (1995): 1409–10. http://dx.doi.org/10.1136/bmj.310.6991.1409b.

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3

Palmer, R., C. Scully, and D. H. Felix. "Nicotine, smoke and patches." British Dental Journal 200, no. 2 (2006): 65. http://dx.doi.org/10.1038/sj.bdj.4813187.

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4

Jarvis, M. J., M. A. Russell, and C. Feyerabend. "Unlicensed nicotine skin patches." BMJ 306, no. 6878 (1993): 647. http://dx.doi.org/10.1136/bmj.306.6878.647.

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5

Ueda, Kimiko. "Nicotine patches in Japan." Lancet 358, no. 9280 (2001): 512. http://dx.doi.org/10.1016/s0140-6736(01)05660-4.

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6

Kalra, Roma, Shashi P. Singh, Juan C. Pena-Philippides, Raymond J. Langley, Seddigheh Razani-Boroujerdi, and Mohan L. Sopori. "Immunosuppressive and Anti-Inflammatory Effects of Nicotine Administered by Patch in an Animal Model." Clinical Diagnostic Laboratory Immunology 11, no. 3 (2004): 563–68. http://dx.doi.org/10.1128/cdli.11.3.563-568.2004.

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ABSTRACT To study the immunological effects of nicotine, there are several rodent models for chronic nicotine administration. These models include subcutaneously implanted miniosmotic pumps, nicotine-spiked drinking water, and self-administration via jugular cannulae. Administration of nicotine via these routes affects the immune system. Smokers frequently use nicotine patches to quit smoking, and the immunological effects of nicotine patches are largely unknown. To determine whether the nicotine patch affects the immune system, nicotine patches were affixed daily onto the backs of Lewis rats
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7

Ruela, André Luís Morais, Eduardo Costa Figueiredo, Aline Gravinez Perissinato, Ana Carolina Zogbi Lima, Magali Benjamim Araújo, and Gislaine Ribeiro Pereira. "In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil." Brazilian Journal of Pharmaceutical Sciences 49, no. 3 (2013): 579–88. http://dx.doi.org/10.1590/s1984-82502013000300020.

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The aim of this study was to develop and validate a method for evaluating the release and skin permeation from transdermal nicotine patches using the vertical diffusion cell (VDC). The VDC is an experimental apparatus employed in research, development, and the pharmaceutical field because it can simulate conditions closest to those established in clinical trials. Two transdermal nicotine delivery systems marketed in Brazil to release 14 mg over 24 hours were evaluated. Release studies were carried out using a regenerated cellulose dialysis membrane and permeation studies were carried out using
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8

Miller, Virginia M., W. Darrin Clouse, Britt H. Tonnessen, et al. "Time and dose effect of transdermal nicotine on endothelial function." American Journal of Physiology-Heart and Circulatory Physiology 279, no. 4 (2000): H1913—H1921. http://dx.doi.org/10.1152/ajpheart.2000.279.4.h1913.

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Nicotine patches are available as an over-the-counter medication for aid in smoking cessation. This study was designed to determine how nicotine patch therapy over time and dose ranges used in smoking cessation programs in humans affects endothelium-dependent relaxations. Dogs were treated with nicotine patches (11, 22, or 44 mg/day) for 2 and 5 wk. Circulating nicotine and oxidized products of nitric oxide (NOx) were measured. Coronary arteries were prepared for measurement of isometric force and aortic endothelial cells were prepared for measurement of mRNA or NO synthase (NOS) activity. Cir
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9

Kang, Jeong Ho, and Sung Kgun Lee. "Progressive nicotine poisoning by multiple transdermal nicotine patches." Journal of Medicine and Life Science 18, no. 2 (2021): 31–34. http://dx.doi.org/10.22730/jmls.2021.18.2.31.

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The pharmacokinetic properties of transdermal nicotine patches (TNPs) are different from those of other routes of nicotine administration; further, acute nicotine poisoning by TNPs may present with different clinical features. In the present report, we describe the case of a 23-year-old woman who was admitted to emergency department (ED) at Jeju National University Hospital with loss of consciousness. Five hours before the ED visit, she used multiple TNPs to attempt suicide. Initially, nausea and vomiting occurred, and the symptoms worsened over time. We immediately removed the TNPs, and the a
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10

&NA;. "Sustained nonsmoking after nicotine patches." Inpharma Weekly &NA;, no. 957 (1994): 14. http://dx.doi.org/10.2165/00128413-199409570-00032.

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11

Serra, Steven J., Julia A. Robertson, and John C. Carey. "Nicotine transdermal patches and pregnancy." American Journal of Obstetrics and Gynecology 183, no. 3 (2000): 778. http://dx.doi.org/10.1067/mob.2000.106978.

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12

&NA;. "More on nicotine transdermal patches." Inpharma Weekly &NA;, no. 837 (1992): 26. http://dx.doi.org/10.2165/00128413-199208370-00058.

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13

WISBORG, KIRSTEN, TINE BRINK HENRIKSEN, LONE BIRK JESPERSEN, and NIELS JØRGEN SECHER. "Nicotine Patches for Pregnant Smokers." Obstetrics & Gynecology 96, no. 6 (2000): 967–71. http://dx.doi.org/10.1097/00006250-200012000-00019.

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14

Marston, Geoffrey Michael, and Irene Dove Cormac. "Nicotine patches and paranoid psychosis." Irish Journal of Psychological Medicine 12, no. 2 (1995): 70–71. http://dx.doi.org/10.1017/s0790966700004262.

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15

Lagrue, G., F. Verra, F. Lebargy, and Matthew Jackson. "Nicotine patches and vascular risks." Lancet 342, no. 8870 (1993): 564. http://dx.doi.org/10.1016/0140-6736(93)91698-l.

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16

Campbell, I. A. "Nicotine patches in general practice." BMJ 306, no. 6888 (1993): 1284–85. http://dx.doi.org/10.1136/bmj.306.6888.1284.

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17

Jameson, M. "Nicotine patches: up in smoke?" JAMA: The Journal of the American Medical Association 268, no. 13 (1992): 1686b—1686. http://dx.doi.org/10.1001/jama.268.13.1686b.

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18

Jameson, Mark. "Nicotine Patches: Up in Smoke?" JAMA: The Journal of the American Medical Association 268, no. 13 (1992): 1686. http://dx.doi.org/10.1001/jama.1992.03490130074032.

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19

Fiore, M. C. "Side effects of nicotine patches." JAMA: The Journal of the American Medical Association 270, no. 22 (1993): 2735b—2735. http://dx.doi.org/10.1001/jama.270.22.2735b.

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20

Gilbert, David G., Bryant M. Stone, and Norka E. Rabinovich. "Overdose symptoms and positive affect in never-established smokers are moderated by nicotine patch type: A between-subjects experimental investigation." F1000Research 11 (August 16, 2022): 937. http://dx.doi.org/10.12688/f1000research.124015.1.

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Background: A growing number of studies have assessed the effects of acute nicotine on affect, cognition, and brain activity in never-established smokers in attempts to identify mechanisms by which nicotine promotes progression to dependence. However, these acute administration studies have not adequately addressed the problem of potential adverse side effects due to lack of tolerance, such as nausea, feelings of sickness, lightheadedness, and general negative affect and malaise – a term referred to as nicotine overdose events (NODEs). Thus, we report the first study to carefully characterize
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21

Sipe, Richard V. Sipe, David C. Buck, and Jeffrey O. Hollinger. "Nicotine Administration In Rabbits Using HabitrolR Nicotine Patches And Nicotine Nasal Spray." Clinical and Experimental Pharmacology and Physiology 27, no. 7 (2000): 480–82. http://dx.doi.org/10.1046/j.1440-1681.2000.03285.x.

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22

Walker, Natalie, Marjolein Verbiest, Tomasz Kurdziel, et al. "Effectiveness and safety of nicotine patches combined with e-cigarettes (with and without nicotine) for smoking cessation: study protocol for a randomised controlled trial." BMJ Open 9, no. 2 (2019): e023659. http://dx.doi.org/10.1136/bmjopen-2018-023659.

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IntroductionEvidence indicates e-cigarettes can help people quit smoking; however, more confirmatory trials are needed. To date, no trials have evaluated the effectiveness and safety of combining nicotine patches with e-cigarettes (with and without nicotine) for smoking cessation.Methods and analysisThis study is a pragmatic, three-arm, community-based, single-blind, randomised trial undertaken in New Zealand. Eligible participants are daily/non-daily smokers, aged ≥18 years, naive e-cigarette users and motivated to quit smoking in the next 2 weeks. Participants (n=1809), recruited using multi
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23

&NA;. "Nicotine patches: effectiveness related to genotype." Inpharma Weekly &NA;, no. 1431 (2004): 10. http://dx.doi.org/10.2165/00128413-200414310-00021.

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24

Woolf, A., K. Burkhart, T. Caraccio, and T. Litovitz. "Childhood Poisoning Involving Transdermal Nicotine Patches." PEDIATRICS 99, no. 5 (1997): e4-e4. http://dx.doi.org/10.1542/peds.99.5.e4.

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25

&NA;. "Nicotine patches improve antipsychotic-induced akathisia." Inpharma Weekly &NA;, no. 1118 (1997): 17. http://dx.doi.org/10.2165/00128413-199711180-00036.

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26

&NA;. "Nicotine patches improve antipsychotic-induced akathisia." Reactions Weekly &NA;, no. 682 (1997): 4. http://dx.doi.org/10.2165/00128415-199706820-00012.

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27

&NA;. "GERD: remove nicotine patches at night." Inpharma Weekly &NA;, no. 994 (1995): 20. http://dx.doi.org/10.2165/00128413-199509940-00038.

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28

&NA;. "War declared against unlicensed nicotine patches." Inpharma Weekly &NA;, no. 880 (1993): 5–6. http://dx.doi.org/10.2165/00128413-199308800-00007.

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29

&NA;. "Nicotine patches useful in general practice." Inpharma Weekly &NA;, no. 888 (1993): 14. http://dx.doi.org/10.2165/00128413-199308880-00028.

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30

Arnaot, M. R. "Nicotine patches may not be safe." BMJ 310, no. 6980 (1995): 663–64. http://dx.doi.org/10.1136/bmj.310.6980.663c.

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31

Lardi, C., S. Vogt, S. Pollak, and A. Thierauf. "Complex suicide with homemade nicotine patches." Forensic Science International 236 (March 2014): e14-e18. http://dx.doi.org/10.1016/j.forsciint.2013.12.017.

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32

McAfee, Timothy A., Terry Bush, T. Mona Deprey, et al. "Nicotine Patches and Uninsured Quitline Callers." American Journal of Preventive Medicine 35, no. 2 (2008): 103–10. http://dx.doi.org/10.1016/j.amepre.2008.04.017.

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33

Dani, John A. "Nicotinic Receptor Activity Alters Synaptic Plasticity." Scientific World JOURNAL 1 (2001): 393–95. http://dx.doi.org/10.1100/tsw.2001.74.

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Studies using specific agonists, antagonists, and lesions have shown that nicotinic cholinergic systems participate in attention, learning, and memory[1,2]. The nicotinic manipulations usually have the greatest influence on difficult tasks or on cognitively impaired subjects[2]. For example, Alzheimer's disease is characterized by a loss of cholinergic projections and nicotinic acetylcholine receptors (nAChRs) in the cortex and hippocampus[3]. Nicotine skin patches can improve learning rates and attention in Alzheimer's patients[4].
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34

Chulurks, Sorrawee, Kulpavee Jitapunkul, Sasimas Katanyutanon, Pisanu Toochinda та Luckhana Lawtrakul. "Stability Enhancement and Skin Permeation Application of Nicotine by Forming Inclusion Complex with β-Cyclodextrin and Methyl-β-Cyclodextrin". Scientia Pharmaceutica 89, № 4 (2021): 43. http://dx.doi.org/10.3390/scipharm89040043.

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Nicotine is widely used in pharmaceutical industries, especially for smoking cessation in the form of transdermal patches. Nicotine gel in the patches has limitations from nicotine instability and high volatility. Thus, a nicotine preservation technique is needed. In this study, a nicotine encapsulation process using methyl-β-cyclodextrin (MβCD) is investigated and compared with β-cyclodextrin (βCD) to evaluate the preservation and skin permeation of nicotine. The M06-2X/6-31G(d,p) density functional theory calculations indicate a 1:1 host–guest molar ratio for the inclusion complex of nicotin
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35

Jimenez Ruiz, CA, S. Florez, A. Ramos, L. Ramos, S. Solano, and E. Fornies. "Smoking cessation with a 16 h nicotine patch: results in a group of hospital workers." European Respiratory Journal 10, no. 3 (1997): 573–75. http://dx.doi.org/10.1183/09031936.97.10030573.

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As part of a programme for the implementation of a Smoking Control Policy in our hospital, an open study, without randomization, of 65 hospital workers, who wanted to give up smoking, was carried out. The characteristics of smoking in each subject were recorded. The Fagerstrom Questionnaire was used to measure the degree of dependence on nicotine. The treatment consisted of the daily use of 16 h nicotine patches for 12 weeks. During the first 4 weeks, the patches contained 15 mg of nicotine, for the second 4 weeks, 10 mg, and for the last 4 weeks 5 mg (per patch and day). Five visits were sche
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36

Vaishnavi, G. Karule, A. Kubde Jitendra, R. Hatwar Pooja, L. Bakal Ravindra, and S. Kathole Khushi. "Innovations in transdermal delivery: Exploring nicotine patches, microneedles and glucose monitoring technologies." GSC Biological and Pharmaceutical Sciences 29, no. 2 (2024): 341–55. https://doi.org/10.5281/zenodo.14760820.

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Transdermal devices for delivering drugs have been invented in response to obstacles caused by oral administration of medications. An adhesive patch comprising medication that is applied topically for transferring a preset proportion of treatment through the skin and into the bloodstream is called a transdermal patch. The method of manufacturing for various transdermal application types, including matrix patches, is described in this review article. Addiction to cigarettes affects millions different people throughout. One example of a nicotine replacement treatment that is currently widely acc
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37

Kras, M., C. Stough, A. Scholey, C. Kure, and D. Camfield. "P.6.f.002 Hypericum perforatum, nicotine patches and combination hypericum perforatum/nicotine patches for smoking cessation." European Neuropsychopharmacology 20 (August 2010): S608—S609. http://dx.doi.org/10.1016/s0924-977x(10)70930-5.

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38

Hajek, Peter, Dunja Przulj, Francesca Pesola, et al. "Electronic cigarettes versus nicotine patches for smoking cessation in pregnancy: a randomized controlled trial." Nature Medicine 28, no. 5 (2022): 958–64. http://dx.doi.org/10.1038/s41591-022-01808-0.

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AbstractNicotine replacement therapy, in the form of nicotine patches, is commonly offered to pregnant women who smoke to help them to stop smoking, but this approach has limited efficacy in this population. Electronic cigarettes (e-cigarettes) are also used by pregnant women who smoke but their safety and efficacy in pregnancy are unknown. Here, we report the results of a randomized controlled trial in 1,140 participants comparing refillable e-cigarettes with nicotine patches. Pregnant women who smoked were randomized to e-cigarettes (n = 569) or nicotine patches (n = 571). In the unadjusted
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39

Lee, Cheol Min, Yu Jin Paek, Yoo Bin Seo, and Eon Sook Lee. "Pharmacotherapy guidelines for smoking cessation in primary healthcare clinics." Journal of the Korean Medical Association 67, no. 4 (2024): 230–39. http://dx.doi.org/10.5124/jkma.2024.67.4.230.

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Background: Cigarette smoking is the leading preventable cause of death, with smoking cessation representing the most effective strategy to reduce the risk of smoking-related diseases. Pharmacotherapeutic interventions for smoking cessation such as nicotine replacement therapy, bupropion, and varenicline aim to manage the symptoms of nicotine cravings and withdrawal. Evidence-based practice guidelines for pharmacotherapy in smoking cessation have been recently developed in Korea.Current Concepts: Among the general population, varenicline is the recommended first-line therapy for smoking cessat
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40

&NA;. "Efficacy of Transdermal Nicotine Patches for Nicotine Replacement and Smoking Cessation." Nurse Practitioner 17, no. 7 (1992): 46???50. http://dx.doi.org/10.1097/00006205-199207000-00013.

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41

&NA;. "Nicotine patches go OTC in the US." Inpharma Weekly &NA;, no. 1050 (1996): 22. http://dx.doi.org/10.2165/00128413-199610500-00052.

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42

&NA;. "Intensive intervention not necessary with nicotine patches." Inpharma Weekly &NA;, no. 906 (1993): 15. http://dx.doi.org/10.2165/00128413-199309060-00026.

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43

TONNESEN, PHILIP, JESPER NORREGAARD, URBAIN SAWE, and KARE SIMONSEN. "Recycling with nicotine patches in smoking cessation." Addiction 88, no. 4 (1993): 533–39. http://dx.doi.org/10.1111/j.1360-0443.1993.tb02060.x.

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44

&NA;. "Two more nicotine patches for the UK." Inpharma Weekly &NA;, no. 866 (1992): 22. http://dx.doi.org/10.2165/00128413-199208660-00051.

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45

JANCIN, BRUCE. "Nicotine Patches Appear Safe for CAD Patients." Internal Medicine News 40, no. 9 (2007): 37. http://dx.doi.org/10.1016/s1097-8690(07)70526-7.

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46

BOSCHERT, SHERRY. "Lidocaine, Nicotine Patches Can Reduce Postoperative Pain." Hospitalist News 1, no. 1 (2008): 10. http://dx.doi.org/10.1016/s1875-9122(08)70018-x.

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47

Jagadeesan, Jagajeevan, Wee Leon Lam, and Jeyaram Srinivasan. "Nicotine Patches on Patients for Free Flaps." Plastic and Reconstructive Surgery 119, no. 1 (2007): 437–38. http://dx.doi.org/10.1097/01.prs.0000233615.54648.63.

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48

DeNelsky, G. Y. "Transdermal nicotine patches: How effective are they?" Cleveland Clinic Journal of Medicine 60, no. 3 (1993): 252–53. http://dx.doi.org/10.3949/ccjm.60.3.252.

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49

Griffith, Richard. "Prescribing nicotine patches to children: caution required." Nurse Prescribing 5, no. 3 (2007): 126–28. http://dx.doi.org/10.12968/npre.2007.5.3.23607.

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50

Yoshifuku, Asuka, Yuko Higashi, Shigeto Matsushita, Kazuhiro Kawai, and Takuro Kanekura. "Transdermal nicotine patches for eosinophilic pustular folliculitis." Journal of Dermatology 40, no. 9 (2013): 711–14. http://dx.doi.org/10.1111/1346-8138.12211.

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