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Journal articles on the topic 'Nikolsky's sign'

Author: Grafiati

Published: 3 June 2025

Last updated: 31 July 2025

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1

Hameed and Khan. "Microscopic Nikolsky's sign." Clinical and Experimental Dermatology 24, no. 4 (1999): 312–14. http://dx.doi.org/10.1046/j.1365-2230.1999.00487.x.

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2

Maity, Subhadeep, Ishita Banerjee, Rupam Sinha, Harshvardhan Jha, Pritha Ghosh, and Subhasish Mustafi. "Nikolsky's sign: A pathognomic boon." Journal of Family Medicine and Primary Care 9, no. 2 (2020): 526. http://dx.doi.org/10.4103/jfmpc.jfmpc_889_19.

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3

Coelho, L. K., L. E. A. Troncon, A. M. F. Roselino, M. S. Campos, and J. L. P. Módena. "Esophageal Nikolsky's Sign in Pemphigus Vulgaris." Endoscopy 29, no. 07 (1997): S 35. http://dx.doi.org/10.1055/s-2007-1004283.

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4

SALOPEK, T. G. "Nikolsky's sign: is it‘dry’ or is it ‘wet’?" British Journal of Dermatology 136, no. 5 (1997): 762–67. http://dx.doi.org/10.1046/j.1365-2133.1997.6711627.x.

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5

SALOPEK, T. G. "Nikolsky's sign: is it‘dry’ or is it ‘wet’?" British Journal of Dermatology 136, no. 5 (1997): 762–67. http://dx.doi.org/10.1111/j.1365-2133.1997.tb03667.x.

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6

Martin, Michael D. "Gingival Nikolsky's Sign is Useful for Clinical Diagnosis." Journal of Evidence Based Dental Practice 9, no. 4 (2009): 217–18. http://dx.doi.org/10.1016/j.jebdp.2009.06.004.

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7

Soni, AbhishekG. "Nikolsky's sign - A clinical method to evaluate damage at epidermal-dermal junction." Journal of Indian Academy of Oral Medicine and Radiology 30, no. 1 (2018): 68. http://dx.doi.org/10.4103/jiaomr.jiaomr_95_17.

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8

Mignogna, Michele D., Giulio Fortuna, Stefania Leuci, Elvira Ruoppo, Flavio Marasca, and Sergio Matarasso. "Nikolsky's Sign on the Gingival Mucosa: A Clinical Tool for Oral Health Practitioners." Journal of Periodontology 79, no. 12 (2008): 2241–46. http://dx.doi.org/10.1902/jop.2008.080217.

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9

Braue, E. H., C. R. Nalls, R. A. Way, J. E. Zallnick, R. G. Rieder, and L. W. Mitcheltree. "Nikolsky's sign: a novel way to evaluate damage at the dermal-epidermal junction*." Skin Research and Technology 3, no. 4 (1997): 245–51. http://dx.doi.org/10.1111/j.1600-0846.1997.tb00193.x.

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10

Saini, Shiv Sajan, and Vinay Vamdev Kulkarni. "Staphylococcal Scalded Skin Syndrome in an Extremely Premature Neonate." Journal of Postgraduate Medicine, Education and Research 50, no. 1 (2016): 39–40. http://dx.doi.org/10.5005/jp-journals-10028-1191.

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ABSTRACT Staphylococcal scalded skin syndrome is a rare diagnosis in neonates. We present an extremely premature neonate presenting with bullous lesions all over the body on day 20 of life. The lesions ruptured leaving erythematous, tender raw areas. Nikolsky's sign was positive and clinical diagnosis of staphylococcal scalded skin syndrome was made. His blood culture grew Staphylococcus aureus and Klebsiella pneumoniae. His umbilical swab culture grew S. aureus. The baby was treated with by cloxacillin, piperacillin/tazobactum and clindamycin. The lesions healed in 7 days. The baby was discha

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11

Alipour, Marzieh, Khalil Khashei Varnamkhasti, and Marzieh Eslami Moghaddam. "A Case Report of Neonatal Pemphigus Vulgaris." Qom Univ Med Sci J 15, no. 4 (2021): 306–11. http://dx.doi.org/10.32598/qums.15.4.306.

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Background and Objectives: Pemphigus vulgaris (PV) is a chronic, rare mucocutaneous autoimmune bullous disease characterized by flaccid blisters and or pustules, with secondary erosions of the mucous membranes or skin. PV threatens the patient life by forming splits within the epidermis, accompanied by acantholysis (separating keratinocytes from each other). Case Presentation: Our case is a term female neonate with PV, born of a 31-year-old mother. On initial examination by a pediatrician, several thin-walled flaccid blisters and burst blisters accompanied with open sores were observed on the

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12

Capocasale, Giorgia, Vera Panzarella, Vito Rodolico, Olga Di Fede, and Giuseppina Campisi. "In vivo optical coherence tomography imaging in a case of mucous membrane pemphigoid and a negative Nikolsky's sign." Journal of Dermatology 45, no. 5 (2018): 603–5. http://dx.doi.org/10.1111/1346-8138.14267.

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13

Moshfeghi, Mersedeh, and Hilary D. Mandler. "Ciprofloxacin-Induced Toxic Epidermal Necrolysis." Annals of Pharmacotherapy 27, no. 12 (1993): 1467–69. http://dx.doi.org/10.1177/106002809302701212.

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OBJECTIVE: To report a case of probable ciprofloxacin-induced toxic epidermal necrolysis (TEN) in an adult with systemic lupus erythematosus (SLE). CASE SUMMARY: A 31-year-old woman with SLE developed a pruritic rash following her first dose of oral ciprofloxacin. She continued taking ciprofloxacin, and the rash progressively worsened, becoming painful and covering her entire body. She discontinued the ciprofloxacin six days later and presented to the hospital, where two days later, her rash began to desquamate with epidermal erosions and a positive Nikolsky's sign. Skin biopsy was positive fo

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14

Wong, Anthony, Andrey Augusto Malvestiti, and Mariana de Figueiredo Silva Hafner. "Stevens-Johnson syndrome and toxic epidermal necrolysis: a review." Revista da Associação Médica Brasileira 62, no. 5 (2016): 468–73. http://dx.doi.org/10.1590/1806-9282.62.05.468.

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SUMMARY Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are uncommon, acute and potentially life-threatening adverse cutaneous drug reactions. These pathologies are considered a hypersensitivity reaction and can be triggered by drugs, infections and malignancies. The drugs most often involved are allopurinol, some antibiotics, including sulfonamides, anticonvulsants such as carbamazepine, and some non-steroid anti-inflammatory drugs (NSAIDs). Necrosis of keratinocytes is manifested clinically by epidermal detachment, leading to scalded skin appearance. The rash begins on th

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15

Miranda Solis, Edwin Marcelo, Yesenia Esthefania Arellano Oleas, and Jessica Lisbeth Vallejo Bayas. "Strategies and projects in the management of autoimmune dermatosis." Salud, Ciencia y Tecnología - Serie de Conferencias 2 (December 20, 2023): 1118. http://dx.doi.org/10.56294/sctconf20231118.

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Introduction: pemphigus vulgaris has been an autoimmune disease characterized by the formation of blisters on the skin and mucous membranes. Its diagnosis and management have represented a clinical challenge due to the variable presentation and potential severity. Therefore, the present study has focused on describing and analyzing the clinical presentation, diagnosis and treatment of pemphigus vulgaris. So that early diagnosis and proper management are emphasized to improve the prognosis of patients. Method: a review of recent scientific literature was conducted and case studies were analyzed

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16

Dr, Jatin Gupta. "Nikolskiy's Sign - A Review." RESEARCH REVIEW International Journal of Multidisciplinary 03, no. 06 (2018): 134–35. https://doi.org/10.5281/zenodo.1258192.

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Autoimmune skin disorders sometimes are characterized by acantholysis, or loss of the normal epithelial cell-to- cell adhesion within the skin(8). Clinically, these disorders present with blistering of the skin and include the pemphigus and pemphigoid groups of disorders. On visual inspection only, these skin conditions are difficult to diagnose and may be confused with other types of skin disorders. Nikolskiy"s sign is a well described clinical sign that can be helpful in differentiating some of the autoimmune skin disorders and even determining their prognosis(9).This article presents the or

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17

Juneja, Manish. "Nikolskiy's sign revisited." Journal of Oral Science 50, no. 2 (2008): 213–14. http://dx.doi.org/10.2334/josnusd.50.213.

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18

Nopriyati, M. Akip Riyan Saputra, Yulia Farida Yahya, and Sarah Diba. "Application of Topical Autologous Platelet-Rich Plasma for Treatment of Pemphigus Foliaceus Wounds: A Case Report." Bioscientia Medicina : Journal of Biomedicine and Translational Research 6, no. 12 (2022): 2509–15. http://dx.doi.org/10.37275/bsm.v6i12.625.

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Background: Pemphigus foliaceus (PF) includes lesions on the skin, generally without involving the mucosa. Wounds in PF arise on the outer layer of the superficial skin, but if left untreated, the wound will not heal and will multiply. Platelet-rich plasma (PRP) containing a variety of different growth factors can be used in wound care. This study was at a time to describe autologous PRP therapy in the treatment of excoriated erosional wounds in patients with pemphigus foliaceus. Case presentation: A woman, 35 years old, married, a housewife living in suburban, comes to the emergency dep

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19

Shah, Amna, Elizabeth Roberts, Shendy Engelina, and Efrosini Carras. "The Nikolsky sign." British Journal of Hospital Medicine 79, no. 9 (2018): C142—C144. http://dx.doi.org/10.12968/hmed.2018.79.9.c142.

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20

Mareeva, A. N., and I. N. Kondrakhina. "Nikolsky’s sign - a rare form of alopecia areata." Vestnik dermatologii i venerologii 91, no. 5 (2015): 97–101. http://dx.doi.org/10.25208/0042-4609-2015-91-5-97-101.

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Two case reports of rare form of alopecia areata - Nikolsky’s sign - were presented. This disease is often associated with nerve system pathology (schizophrenia, epilepsy, hysteroid reactions). A special feature of first monitoring was the combination of Nikolsky’s sign as a form of alopecia areata and Down syndrome. Trichodermatoscopy with detection of characteristic stigmas of alopecia areata can provide assistance in differential diagnostics of this disease and other disorders.

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21

Apalla, Zoe, Aimilios Lallas, Elena Sotiriou, Elizabeth Lazaridou, Efstratios Vakirlis, and Dimitrios Ioannides. "Stellate erosion: the dermoscopic Nikolsky sign?" European Journal of Dermatology 27, no. 6 (2017): 659–60. http://dx.doi.org/10.1684/ejd.2017.3114.

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22

SAGHER, F., B. BERCOVICI, and R. ROMEM. "Nikolsky sign on cervix uteri in pemphigus." British Journal of Dermatology 90, no. 4 (2006): 407–11. http://dx.doi.org/10.1111/j.1365-2133.1974.tb06425.x.

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23

Wong, Christina Y., Steven D. Billings, and Christine B. Warren. "Positive Nikolsky Sign and Pinpoint “Lakes of Pus”." SKIN The Journal of Cutaneous Medicine 1, no. 2 (2017): 86. http://dx.doi.org/10.25251/10.25251/skin.1.2.5.

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A 54-year-old man with a past medical history of paraplegia, osteomyelitis, sacral decubitus ulcer, suprapubic catheter, and several reported drug eruptions was seen for evaluation of skin sloughing without any tenderness to palpation. He reported being on chronic oral antibiotics including amoxicillin/clavulanic acid and ciprofloxacin over the past two years for osteomyelitis. Two days prior to evaluation, he had been hospitalized for osteomyelitis of the left iliac bone and was treated with intravenous vancomycin and meropenem. Initial evaluation revealed widespread Nikolsky sign with extens

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24

Wong, Christina, Steven Billings, and Christine Warren. "Positive Nikolsky Sign and Pinpoint “Lakes of Pus”." SKIN: The Journal of Cutaneous Medicine 1, no. 2 (2017): 86–90. http://dx.doi.org/10.25251/skin.1.2.5.

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25

MOSS, C., and E. GUPTA. "The Nikolsky sign in staphylococcal scalded skin syndrome." Archives of Disease in Childhood 79, no. 3 (1998): 290. http://dx.doi.org/10.1136/adc.79.3.290.

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26

Shakeri, Aria. "Pyotr Vasilyevich Nikolsky—The Man Behind the Sign." JAMA Dermatology 154, no. 2 (2018): 181. http://dx.doi.org/10.1001/jamadermatol.2017.5164.

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27

Edwin, Dias, and Rai Vijetha. "Three years old Child with Toxic Epidermal Necrolysis due to Paracetamol tablet ingestion." International Journal of Health Sciences and Pharmacy (IJHSP) 1, no. 2 (2017): 68–71. https://doi.org/10.5281/zenodo.1129600.

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A 3 years old child with a history of ingestion of Paracetamol tablet due to fever Presented with rashes all over the body, nikolsky sign positive diagnosed as toxic epidermal necrosis, was treated With supportive management antibiotics and dexamethasone nursed on banana leaves which were autoclaved, the child improved within 10 days.

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28

Kaur, S. "Positive Nikolsky's and bulla-spread signs in acute bullous lichen planus." Archives of Dermatology 123, no. 9 (1987): 1122–23. http://dx.doi.org/10.1001/archderm.123.9.1122.

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29

Kaur, Surrinder. "Positive Nikolsky's and Bulla-Spread Signs in Acute Bullous Lichen Planus." Archives of Dermatology 123, no. 9 (1987): 1122. http://dx.doi.org/10.1001/archderm.1987.01660330029004.

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30

Doubleday, C. William. "Who is Nikolsky and what does his sign mean?" Journal of the American Academy of Dermatology 16, no. 5 (1987): 1054–55. http://dx.doi.org/10.1016/s0190-9622(87)80419-x.

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31

Bourayou, Rafik, Nolwenn Le Sache, and Isabelle Kone-Paut. "Positive Nikolsky Sign due to Staphylococcal Scaled Skin Syndrome." Journal of Pediatrics 159, no. 5 (2011): 868. http://dx.doi.org/10.1016/j.jpeds.2011.07.019.

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32

Saggini, Andrea, Carlo Cota, and Lorenzo Cerroni. "Incidental Acantholysis in Hailey–Hailey Disease (Microscopic Nikolsky Sign)." American Journal of Dermatopathology 42, no. 5 (2020): e61-e64. http://dx.doi.org/10.1097/dad.0000000000001534.

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33

Ghoneim, Sara, Aun Shah, and Amy Calderon. "Esophageal Nikolsky’s Sign: A Rare Finding in a Patient with Bullous Pemphigoid." Case Reports in Gastroenterology 13, no. 3 (2019): 445–49. http://dx.doi.org/10.1159/000503898.

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Bullous pemphigoid (BP) is a chronic relapsing autoimmune blistering disease that typically affects middle-age and elderly patients. It can manifest with varying degrees of mucosal involvement in addition to characteristic skin findings. However, esophageal involvement is very rare. We report a case of a 57-year-old female with BP who presented with epigastric pain and melena. She underwent an esophagogastroduodenoscopy which induced bullae seen only upon withdrawal of the endoscope. This finding is analogous to the dermatological finding of Nikolsky’s sign. Gentle insertion and withdrawal of

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34

Ghoneim, Sara, Aun Shah, and Amy Calderon. "1791 Esophageal Nikolsky’s Sign: A Rare Finding in a Patient With Bullous Pemphigoid." American Journal of Gastroenterology 114, no. 1 (2019): S1004—S1005. http://dx.doi.org/10.14309/01.ajg.0000596696.13337.2f.

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35

Inamadar, ArunC, KeshavmurthyA Adya, and Aparna Palit. "A simple and succinct simulation of Nikolsky phenomenon and sign." Indian Dermatology Online Journal 11, no. 3 (2020): 465. http://dx.doi.org/10.4103/idoj.idoj_247_19.

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36

Gür Çetinkaya, Pınar, Bülent Enis Şekerel, Özge Uysal Soyer, and Ümit Murat Şahiner. "A Rare Case of Pediatric Bullous Spontaneous Acute Urticaria." Medical Principles and Practice 27, no. 5 (2018): 493–95. http://dx.doi.org/10.1159/000491586.

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Objective: Acute spontaneous bullous urticaria is an extremely rare entity, and there are few reports with blister formation in acute urticaria patients. Clinical Presentation and Intervention: We present a 2-year-old girl who was admitted for bullous spontaneous acute urticaria; the underlying reason for this was not detected. Nikolsky’s sign and Darier’s sign were negative. Lesions were not compatible with erythema multiforme. However, biopsy was not allowed to be performed. Because of this, the underlying pathogenesis could not be clarified. The patient recovered by a short course of antihi

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37

Bahalou, M. H., B. Hemmaoui, and A. Jahidi. "Pemphigus Vulgaris: A Case Report." Scholars Journal of Medical Case Reports 13, no. 07 (2025): 1549–51. https://doi.org/10.36347/sjmcr.2025.v13i07.005.

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Pemphigus is an intraepithelial autoimmune blistering dermatosis. It often begins as a mucosal-only phase, primarily affecting the oral mucosa. When skin involvement occurs, it is typically secondary and presents as flaccid blisters on otherwise healthy skin, quickly replaced by post-bullous erosions with an epidermal collar. Nikolsky’s sign is positive in perilesional skin. Diagnosis is based on histological examination showing intraepithelial blistering with acantholytic cells and the presence of antibodies on direct immunofluorescence. Treatment relies on low-dose systemic corticosteroids c

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38

Shiohara, Junko, Sonoe Ono, Toshie Endo, and Kazuhiko Kaneko. "Impetigo contagiosa with Nikolsky sign in adult patient of advanced malignant melanoma." Journal of Dermatology 42, no. 10 (2015): 1013–14. http://dx.doi.org/10.1111/1346-8138.13003.

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39

Mahendra Kumar, R., Sanatkumar Nyamagoud, Krishna Deshpande, and Ankitha Kotian. "Amoxicillin Induced Steven Johnson’s Syndrome: A Case Report." Journal of Drug Delivery and Therapeutics 10, no. 4-s (2020): 220–22. http://dx.doi.org/10.22270/jddt.v10i4-s.4205.

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Stevens-Johnson syndrome (SJS) is a very rare, potentially fatal skin reaction that is typically the result of reaction to the drug. In particular, SJS is characterized by extensive skin and mucous membrane lesions (i.e. mouth, nose, esophagus, anus, and genitalia), epidermis detachment, and acute skin blisters. In 95 % of case reports, drugs were found to be an important cause for the development of SJS. This story is a case of A 42 year old male hospitalized with rashes all over the body and fever, after oral consumption of Amoxicillin drug for sore throat. This case study discusses the poss

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40

Gupta, Ira, Aastha Singh, Nidhi Gupta, and Rohit Gupta. "Gingival Pemphigus Vulgaris-Challenges and Solution : A Case Report." UNIVERSITY JOURNAL OF DENTAL SCIENCES 6, no. 2 (2020): 75–78. http://dx.doi.org/10.21276/ujds.2020.6.2.1.

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Pemphigus vulgaris (PV) is a potentially life threatening and rare mucocutaneous disease that usually manifests first in the oral cavity and may later spread to the skin or other mucous membrane. Lesions may occur anywhere on the mucosa but it is unusual for PV to present over the gingiva as a primary site of involvement. A 64 year old female patient reported with a chief complaint of reddish, painful gums with burning sensation since 8 years. The diagnosis of PV is based on clinical findings (Nikolsky’s sign positive) and confirmed by histopathological analysis. Medications were prescribed as

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41

Savitri, Ketut Alit Pinidha, Ketut Suteja Wibawa, and Komang Harry Supradnyan. "Positive nikolsky sign and “pinpoint lake of pus” in acute generalized exanthematous pustulosis: a case report." Intisari Sains Medis 11, no. 1 (2020): 97. http://dx.doi.org/10.15562/ism.v11i1.579.

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42

Auvens, C., B. Bach, L. Leveque, et al. "Signe de Nikolsky au cours d’une poussée de dermatomyosite : à propos d’un cas." La Revue de Médecine Interne 39 (June 2018): A231—A232. http://dx.doi.org/10.1016/j.revmed.2018.03.232.

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43

Santiago, Luís, Rosa Mascarenhas, Óscar Tellechea, and Margarida Gonçalo. "Toxic epidermal necrolysis-like subacute cutaneous lupus erythematosus associated with lung carcinoma." BMJ Case Reports 12, no. 10 (2019): e231152. http://dx.doi.org/10.1136/bcr-2019-231152.

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Specific vesiculobullous skin lesions in lupus erythematosus (LE) are rare and must be differentiated from toxic epidermal necrolysis (TEN), TEN-like dermatoses and other vesiculobullous conditions. We report a patient with typical subacute cutaneous lupus erythematous that progressed with large sheet-like areas of epidermal detachment and Nikolsky sign resembling TEN. She had a serological profile suggestive of underlying connective tissue disease, histological findings of interface dermatitis with a lymphocytic infiltrate, positive direct immunofluorescence, resolution with immunomodulation

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44

Chandraratne, S. H., C. Udagedara, Y. L. B. Karunaratne, and C. Ekanayake. "Co-occurrence of toxic epidermal necrolysis in a human immune deficiency virus infected person due to elthrombopag or ofloxacin – a rare occurrence." Sri Lanka Journal of Dermatology 22, no. 1 (2021): 78–80. http://dx.doi.org/10.4038/tsljd.v22i1.19.

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Toxic epidermal necrolysis (TEN), a severe drug reaction which is more commonly seen in human immune deficiency virus (HIV) infected persons. It occurs commonly with anti-retroviral treatment and sulfonamides. TEN is reported previously with ofloxacin. But there are no reported cases of elthrombopag induced TEN. Early identification and withdrawal of the culprit will enhance rapid recovery and less mortality. Reporting the noted medications vulnerable for TEN will help medical personal in identifying the drug reaction and causative. We are reporting a 45 years old male with HIV infection

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45

Belmourida, Siham, Meriame Meziane, Nadia Ismaili, Laila Benzekri, and Karima Senouci. "Unilateral bullous pemphigoid in a hemiplegic patient." Our Dermatology Online 12, no. 2 (2022): 229–30. http://dx.doi.org/10.7241/ourd.20222.32.

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Sir, Bullous pemphigoid (BP) is the most common autoimmune bullous dermatosis, mainly affecting the elderly. Its association with neurological diseases has been reported for several years in several studies, including with strokes. We report a new case of unilateral BP in a hemiplegic patient. A 78-year-old patient with a history of hypertensive and ischemic heart disease and ischemic stroke three years ago was admitted for pruriginous bullous dermatosis evolving for one month prior to admission. A general examination revealed right hemiplegia with facial involvement and aphasia. A dermatologi

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46

Chavan, R. B., V. A. Belgaumkar, N. S. Deshmukh, and A. M. Pawar. "Toxic epidermal necrolysis like acute cutaneous lupus erythematous or drug induced toxic epidermal necrolysis: case report of a diagnostic dilemma." International Journal of Research in Dermatology 6, no. 4 (2020): 563. http://dx.doi.org/10.18203/issn.2455-4529.intjresdermatol20202667.

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<p>Systemic lupus erythematosus (SLE) is an autoimmune disorder causing microvascular inflammation with generation of antinuclear auto-antibodies. It can have varied presentations and its coexistence with other disorders makes diagnosis and management all the more challenging. We describe a young male, known case of SLE and pulmonary tuberculosis on anti-tubercular treatment presenting with sudden onset diffuse maculopapular dusky rash, oral lesions, fever, joint pain and photosensitivity. Positive Nikolsky’s sign on clinical examination, epidermal necrosis on histopathology, negative di

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47

Yang, Jie, Shicheng Jiao, and Min Zhang. "Use of minocycline for the treatment of prurigo pigmentosa with intraepidermal vesiculation: a case report." Journal of International Medical Research 49, no. 5 (2021): 030006052110155. http://dx.doi.org/10.1177/03000605211015593.

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Pruritus pigmentosa is a skin disease mainly characterized by pruritus, inflammatory rash and reticular and macular pigmentation. The disease more commonly affects young women and may persist for several years. In this article, we report a case of a 20-year-old female patient who presented with erythema and blisters on the neck and trunk with pruritus for 20 days. Dermatological examination revealed a reticular distribution of erythema on the chest and abdomen and some areas of erythema covered with crusts. Additionally, blisters and bullae with clear fluid and negative Nikolsky’s sign were no

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48

Hoseininasab, Ali, Reza Sinaei, Maedeh Jafari, and Parvin Abbaslu. "Staphylococcal Scalded Skin Syndrome Superinfection in a Child with COVID-19: A Brief Case Report." Journal of Kerman University of Medical Sciences 29, no. 6 (2022): 565–67. http://dx.doi.org/10.34172/jkmu.2022.70.

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Background: While the exact prevalence of bacterial co-infection and superinfection in children with coronavirus disease 2019 (COVID-19) remains unclear, numerous scattered reports of it are on the rise. Case Presentation: Our case was a 14-month-old infant with fever, truncal erythema, and scalded skin in flexor folds and also in perianal and perioral regions. A positive Nikolsky’s sign was observed. The oropharyngeal mucosa was intact. The patient was diagnosed with staphylococcal scalded skin syndrome (SSSS) according to clinical features and a skin culture report. Due to the general impact

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Seneviratne, Jayamini. "Nikolsky′s sign in staphylococcal scalded skin syndrome: A new diagnostic clue to the level of epidermal split." Indian Journal of Paediatric Dermatology 13, no. 1 (2012): 51. http://dx.doi.org/10.4103/2319-7250.102818.

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Taniowas, Paul O., Tara S. Kairupan, Marlyn G. Kapantow, and Aryani Adji. "Bullous Pemphigoid in a Women with Type 2 Diabetes Mellitus: A Case Report." e-CliniC 10, no. 1 (2022): 131. http://dx.doi.org/10.35790/ecl.v10i1.39085.

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Abstract:

Abstract: Bullous Pemphigoid (BP) is an autoimmune disease with subepidermal blisters that are generally minimally itchy to non-itchy. It usually occurs in old age, but sometimes in children and young adults. Clinical presentation shows large, tense-walled blisters on normal or erythematous skin, mostly at the folds, lower abdomen, thighs, but they can appear anywhere. Therapy of BP is aimed to treat skin and mucous lesions as soon as possible and to reduce itchiness, therefore, the quality of life will be improved. The first line therapy is oral and topical corticosteroids, with an initial do

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