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Journal articles on the topic 'NIMA'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wu, L., S. A. Osmani, and P. M. Mirabito. "A Role for NIMA in the Nuclear Localization of Cyclin B in Aspergillus nidulans." Journal of Cell Biology 141, no. 7 (1998): 1575–87. http://dx.doi.org/10.1083/jcb.141.7.1575.

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NIMA promotes entry into mitosis in late G2 by some mechanism that is after activation of the Aspergillus nidulans G2 cyclin-dependent kinase, NIMXCDC2/NIMECyclin B. Here we present two independent lines of evidence which indicate that this mechanism involves control of NIMXCDC2/NIMECyclin B localization. First, we found that NIMECyclin B localized to the nucleus and the nucleus-associated organelle, the spindle pole body, in a NIMA-dependent manner. Analysis of cells from asynchronous cultures, synchronous cultures, and cultures arrested in S or G2 showed that NIMECyclin B was predominantly n

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2

Dutta, Partha, Melanie Molitor-Dart, Joseph L. Bobadilla, et al. "Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice." Blood 114, no. 17 (2009): 3578–87. http://dx.doi.org/10.1182/blood-2009-03-213561.

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Abstract In mice and humans, the immunologic effects of developmental exposure to noninherited maternal antigens (NIMAs) are quite variable. This heterogeneity likely reflects differences in the relative levels of NIMA-specific T regulatory (TR) versus T effector (TE) cells. We hypothesized that maintenance of NIMA-specific TR cells in the adult requires continuous exposure to maternal cells and antigens (eg, maternal microchimerism [MMc]). To test this idea, we used 2 sensitive quantitative polymerase chain reaction (qPCR) tests to detect MMc in different organs of NIMAd-exposed H2b mice. MMc

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3

Osmani, S. A., G. S. May, and N. R. Morris. "Regulation of the mRNA levels of nimA, a gene required for the G2-M transition in Aspergillus nidulans." Journal of Cell Biology 104, no. 6 (1987): 1495–504. http://dx.doi.org/10.1083/jcb.104.6.1495.

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The temperature-sensitive cell cycle mutation nimA5 causes nuclei of Aspergillus nidulans to be blocked in late G2 at restrictive temperature. Under these conditions the spindle pole body divides but does not separate and the mitotic index drops to zero. If nimA5 is blocked for more than one doubling time and then shifted from restrictive to permissive temperature, nuclei immediately enter mitosis, the mitotic spindle forms, and the chromosomes condense (Oakley, B. R., and N. R. Morris, 1983, J. Cell Biol., 96:1155-8). We have cloned the wild-type nimA gene by DNA-mediated complementation of t

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4

Opiela, Shannon J., Robert B. Levy, and Becky Adkins. "Murine neonates develop vigorous in vivo cytotoxic and Th1/Th2 responses upon exposure to low doses of NIMA-like alloantigens." Blood 112, no. 4 (2008): 1530–38. http://dx.doi.org/10.1182/blood-2007-08-106500.

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AbstractEarly life exposure to noninherited maternal antigens (NIMAs) may occur via transplacental transfer and/or breast milk. There are indications that early life exposure to NIMAs may lead to lifelong tolerance. However, there is mounting evidence that exposure to NIMAs may also lead to immunologic priming. Understanding how these different responses arise could be critical in transplantation with donor cells expressing NIMAs. We recently reported that murine neonates that received a transplant of low doses of NIMA-like alloantigens develop vigorous memory cytotoxic responses, as assessed

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5

De Souza, Colin P. C., Kevin P. Horn, Kathryn Masker, and Stephen A. Osmani. "The SONBNUP98 Nucleoporin Interacts With the NIMA Kinase in Aspergillus nidulans." Genetics 165, no. 3 (2003): 1071–81. http://dx.doi.org/10.1093/genetics/165.3.1071.

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Abstract The Aspergillus nidulans NIMA kinase is essential for mitotic entry. At restrictive temperature, temperature-sensitive nimA alleles arrest in G2, before accumulation of NIMA in the nucleus. We performed a screen for extragenic suppressors of the nimA1 allele and isolated two cold-sensitive son (suppressor of nimA1) mutants. The sonA1 mutant encoded a nucleoporin that is a homolog of yeast Gle2/Rae1. We have now cloned SONB, a second nucleoporin genetically interacting with NIMA. sonB is essential and encodes a homolog of the human NUP98/NUP96 precursor. Similar to NUP98/NUP96, SONBNUP

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6

Matsuoka, Ken-ichi, Tatsuo Ichinohe, Shoji Asakura, Daigo Hashimoto, Mitsune Tanimoto, and Takanori Teshima. "Fetal Tolerance to Maternal Antigens Improves the Outcome of Allogeneic Bone Marrow Transplantation by a CD4+CD25+ T Cell-Dependent Mechanism." Blood 106, no. 11 (2005): 451. http://dx.doi.org/10.1182/blood.v106.11.451.451.

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Abstract The lack of donor availability is a major limitation to the widespread use of allogeneic HSCT and therefore it would be beneficial to identify permissible HLA mismatches. The maternal and fetal antigens which are transmitted through the bi-directional transplacental passage during pregnancy may induce tolerance to noninherited maternal antigens (NIMAs) in offspring and to inherited paternal antigens (IPAs) in the mother. Using mouse models of BMT, we investigated whether fetal-maternal tolerance could affect the outcome of allogeneic BMT. To generate NIMA-exposed mice, we used the F1

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7

Ye, Xiang S., Russell R. Fincher, Alice Tang, Aysha H. Osmani, and Stephen A. Osmani. "Regulation of the Anaphase-promoting Complex/Cyclosome bybimA APC3 and Proteolysis of NIMA." Molecular Biology of the Cell 9, no. 11 (1998): 3019–30. http://dx.doi.org/10.1091/mbc.9.11.3019.

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Surprisingly, although highly temperature-sensitive, thebimA1 APC3 anaphase-promoting complex/cyclosome (APC/C) mutation does not cause arrest of mitotic exit. Instead, rapid inactivation ofbimA1 APC3 is shown to promote repeating oscillations of chromosome condensation and decondensation, activation and inactivation of NIMA and p34cdc2 kinases, and accumulation and degradation of NIMA, which all coordinately cycle multiple times without causing nuclear division. ThesebimA1 APC3-induced cell cycle oscillations require active NIMA, because a nimA5 +bimA1 APC3 double mutant arrests in a mitotic

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8

Aoyama, Kazutoshi, Ken-ichi Matsuoka, Daigo Hashimoto, et al. "Breast-Feeding Mediates Feto-Maternal Tolerance and Improves Outcome of Allogeneic Bone Marrow Transplantation." Blood 110, no. 11 (2007): 2165. http://dx.doi.org/10.1182/blood.v110.11.2165.2165.

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Abstract The widespread application of hematopoietic stem cell transplantation (HSCT) is limited by lack of a histocompatible donor in a proportion of patients who have a rare HLA haplotype. For these patients, allogeneic HSCT from an HLA-mismatched relative donor is complicated with a high incidence of severe graft-versus-host disease (GVHD). Exposure to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantation later in life. We recently demonstrated in a mouse model that a “child-to-mother” BMT from a NIMA-exposed donor reduced the mortality and morbidity

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9

Nurmuxamedov, Ulugʻbek. "KORPUS NIMA VA U NIMA MAQSADDA KERAK?" COMPUTER LINGUISTICS: PROBLEMS, SOLUTIONS, PROSPECT 1, no. 1 (2021): 22. http://dx.doi.org/10.52773/cl:psp/vol_1_issue_1/a4.

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10

Almamatov, Jasur Mirza o`g`li, and Ruxshona Dilshod qizi Bozorova Ruxshona Dilshod qizi Bozorova. "IMMUNITET NIMA VA U NIMA UCHUN KERAK?" Международный научный журнал «Научный импульс» 1, no. 8 (2023): 987–88. https://doi.org/10.5281/zenodo.7809053.

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11

Aoyama, Kazutoshi, Motoko Koyama, Ken-ichi Matsuoka, et al. "Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens." Blood 113, no. 8 (2009): 1829–33. http://dx.doi.org/10.1182/blood-2008-05-155283.

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AbstractExposure of offspring to noninherited maternal antigens (NIMAs) during pregnancy may have an impact on transplantations performed later in life. Using a mouse model, we recently showed that bone marrow transplantation (BMT) from NIMA-exposed offspring to the mother led to a reduction of graft-versus-host disease (GVHD). Since offspring can also be exposed to NIMAs by breastfeeding after birth, we tested whether breast milk could mediate the tolerogenic NIMA effect. We found that oral exposure to NIMAs by breastfeeding alone was sufficient to reduce GVHD, and that in utero exposure to N

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12

Matsuoka, Ken-ichi, Tatsuo Ichinohe, Daigo Hashimoto, Shoji Asakura, Mitsune Tanimoto, and Takanori Teshima. "Fetal tolerance to maternal antigens improves the outcome of allogeneic bone marrow transplantation by a CD4+CD25+ T-cell–dependent mechanism." Blood 107, no. 1 (2006): 404–9. http://dx.doi.org/10.1182/blood-2005-07-3045.

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Abstract The lack of donor availability is a major limitation to the widespread use of allogeneic hematopoietic stem cell transplantation, and therefore it would be beneficial to identify less immunogenic HLA mismatches. The maternal and fetal antigens that are transmitted through the bidirectional transplacental passage during pregnancy may induce tolerance to noninherited maternal antigens (NIMAs) in offspring and to inherited paternal antigens (IPAs) in the mother. Using mouse models of bone marrow transplantation (BMT), we found that a “child-to-mother” BMT from a NIMA-exposed donor reduce

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13

Wang, Yahong, Honghong Shen, Quangui Yin, et al. "Effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel in vitro and vivo." Tumor Biology 39, no. 5 (2017): 101042831769975. http://dx.doi.org/10.1177/1010428317699754.

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NIMA-related kinase 2B has been known to be an important centrosome regulatory factor. The aim of this study was to investigate the effect of NIMA-related kinase 2B on the sensitivity of breast cancer to paclitaxel. We detected the expression of NIMA-related kinase 2B messenger RNA in MCF-10 cells, including MCF-10A, MCF-10AT, MCF-10DCIS.com , and MCF-10CA1a. The influence of NIMA-related kinase 2B in nude mouse was also detected. The association between NIMA-related kinase 2B and clinicopathological factors was explored in invasive ductal carcinoma tissues. NIMA-related kinase 2B was lowly ex

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14

Coureaux-Rojas, Laritza, and María de los Ángeles Cuevas-Gandaria. "Efectividad de la cariología de mínima intervención en escolares de seis a nueve años." Mediciego 30 (September 20, 2024): e3954. https://doi.org/10.5281/zenodo.13773125.

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<strong>Introducción:</strong> la cariología de mínima intervención acorta el ciclo de pérdida del tejido remanente, característico de los tratamientos traumáticos. Esto es fundamental para preservar la salud bucal, sobre todo en los pacientes pediátricos. <strong>Objetivo:</strong> evaluar la efectividad de la cariología de mínima intervención, en escolares de seis a nueve años. <strong>Métodos:</strong> se realizó una investigación cuasiexperimental con grupo de control en 86 escolares at

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15

OSMANI, Stephen A., and Xiang S. YE. "Cell cycle regulation in Aspergillus by two protein kinases." Biochemical Journal 317, no. 3 (1996): 633–41. http://dx.doi.org/10.1042/bj3170633.

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Great progress has recently been made in our understanding of the regulation of the eukaryotic cell cycle, and the central role of cyclin-dependent kinases is now clear. In Aspergillus nidulans it has been established that a second class of cell-cycle-regulated protein kinases, typified by NIMA (encoded by the nimA gene), is also required for cell cycle progression into mitosis. Indeed, both p34cdc2/cyclin B and NIMA have to be correctly activated before mitosis can be initiated in this species, and p34cdc2/cyclin B plays a role in the mitosis-specific activation of NIMA. In addition, both kin

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16

Govindaraghavan, Meera, Alisha A. Lad, and Stephen A. Osmani. "The NIMA Kinase Is Required To Execute Stage-Specific Mitotic Functions after Initiation of Mitosis." Eukaryotic Cell 13, no. 1 (2013): 99–109. http://dx.doi.org/10.1128/ec.00231-13.

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ABSTRACTThe G2-M transition inAspergillus nidulansrequires the NIMA kinase, the founding member of the Nek kinase family. Inactivation of NIMA results in a late G2arrest, while overexpression of NIMA is sufficient to promote mitotic events independently of cell cycle phase. Endogenously tagged NIMA-GFP has dynamic mitotic localizations appearing first at the spindle pole body and then at nuclear pore complexes before transitioning to within nuclei and the mitotic spindle and back at the spindle pole bodies at mitotic exit, suggesting that it functions sequentially at these locations. Since NIM

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17

Lies, C. M., J. Cheng, S. W. James, N. R. Morris, M. J. O'Connell, and P. M. Mirabito. "BIMAAPC3, a component of the Aspergillus anaphase promoting complex/cyclosome, is required for a G2 checkpoint blocking entry into mitosis in the absence of NIMA function." Journal of Cell Science 111, no. 10 (1998): 1453–65. http://dx.doi.org/10.1242/jcs.111.10.1453.

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Temperature sensitive (ts) nimA mutants of Aspergillus nidulans arrest at a unique point in G2 which is post activation of CDC2. Here we show that this G2 arrest is due to loss of nimA function and that it is dependent on BIMAAPC3, a component of the anaphase promoting complex/cyclosome (APC/C). Whereas nimA single mutants arrested in G2 with decondensed chromatin and interphase microtubule arrays, nimA, bimAAPC3 double mutants arrested growth with condensed chromatin and aster-like microtubule arrays. nimA, bimAAPC3 double mutants entered mitosis with kinetics similar to bimAAPC3 single mutan

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18

Ukil, Leena, Archana Varadaraj, Meera Govindaraghavan, Hui-Lin Liu, and Stephen A. Osmani. "Copy Number Suppressors of the Aspergillus nidulans nimA1 Mitotic Kinase Display Distinctive and Highly Dynamic Cell Cycle-Regulated Locations." Eukaryotic Cell 7, no. 12 (2008): 2087–99. http://dx.doi.org/10.1128/ec.00278-08.

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ABSTRACT The Aspergillus nidulans NIMA kinase is essential for mitosis and is the founding member of the conserved NIMA-related kinase (Nek) family of protein kinases. To gain insight into NIMA function, a copy number suppression screen has been completed that defines three proteins termed MCNA, MCNB, and MCNC (multi-copy-number suppressor of nimA1 A, B, and C). All display a distinctive and dynamic cell cycle-specific distribution. MCNC has weak similarity to Saccharomyces cerevisiae Def1 within a shared CUE-like domain. MCNC, like Def1, is a cytoplasmic protein with slow mobility during sodi

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19

Shen, Kuo-Fang, and Stephen A. Osmani. "Regulation of mitosis by the NIMA kinase involves TINA and its newly discovered partner, An-WDR8, at spindle pole bodies." Molecular Biology of the Cell 24, no. 24 (2013): 3842–56. http://dx.doi.org/10.1091/mbc.e13-07-0422.

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The NIMA kinase is required for mitotic nuclear pore complex disassembly and potentially controls other mitotic-specific events. To investigate this possibility, we imaged NIMA–green fluorescent protein (GFP) using four-dimensional spinning disk confocal microscopy. At mitosis NIMA-GFP locates to spindle pole bodies (SPBs), which contain Cdk1/cyclin B, followed by Aurora, TINA, and the BimC kinesin. NIMA promotes NPC disassembly in a spatially regulated manner starting near SPBs. NIMA is also required for TINA, a NIMA-interacting protein, to locate to SPBs during initiation of mitosis, and TIN

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20

Talebi, Hossein, and Peyman Milanfar. "NIMA: Neural Image Assessment." IEEE Transactions on Image Processing 27, no. 8 (2018): 3998–4011. http://dx.doi.org/10.1109/tip.2018.2831899.

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21

Shomurodova, Maftuna. "TARIX BIZGA NIMA BERADI?" Science technology & Digital finance 1, no. 4 (2023): 362–64. https://doi.org/10.5281/zenodo.10264158.

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Tarix o'tmish haqida ma'lumot beruvchi va saqlovchi xususiyatlarga ega bo'lgan va uni anglash jarayoni bo'lib, ajdodlar, inson va insoniyatning tarixiy tajribasi haqida mushohada yuritishni aks ettiruvchi ijtimoiy xotiradir. Shu bilan birga, tarix insonning o'z-o'zini anglashi jarayonidagi asosiy omil hisoblanadi. Ushbu maqolada, aynan tarixni o'rganishning ahamiyati haqida so'z boradi va bugungi kunda ushbu fanni o'rgatishdagi yo'l qo'yilayotgan xatolar tahlil qilinadi.

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22

Guthrie, K. A., N. R. Tishkevich, and J. L. Nelson. "Non-inherited maternal human leukocyte antigen alleles in susceptibility to familial rheumatoid arthritis." Annals of the Rheumatic Diseases 68, no. 1 (2008): 107–9. http://dx.doi.org/10.1136/ard.2008.092312.

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Objectives:Some patients with rheumatoid arthritis (RA) lack RA-associated human leukocyte antigen (HLA) alleles. Prior studies investigated non-inherited maternal HLA alleles (NIMA) in RA risk with conflicting results.Methods:We examined NIMA in a large cohort of families from the North American Rheumatoid Arthritis Consortium (NARAC).Results:Among 620 patients with 1 or both parents having a HLA genotype, patients with RA informative for analysis included 176 without HLA-DRB1*04 and 86 without the HLA shared epitope (SE). The frequency of NIMA encoding HLA-DR4 or the SE was compared to the n

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23

Kinder, Jeremy Michael, Tony Jiang, James Ertelt, et al. "Mother’s ‘genetic’ little helpers: microchimeric maternal cells promote reproductive fitness and survival of non-inherited traits." Journal of Immunology 196, no. 1_Supplement (2016): 207.15. http://dx.doi.org/10.4049/jimmunol.196.supp.207.15.

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Abstract Reproductive success among outbred placental mammalian species requires active tolerance in mothers to foreign paternal antigens expressed by the developing fetus. Although this essential necessity for immunological tolerance has primarily been examined from the perspective of maternal responsiveness to foreign paternal antigens expressed by the developing fetus, exposure to maternal tissue during in utero development also imprints tolerance to genetically foreign non-inherited maternal antigens (NIMA) that persists into adulthood. Nonetheless, until now the biological advantages rein

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24

Kuznetsov, Alexey. "GHAZAL GENRE IN NIMA YUSHIJ’S POETIC." Проблемы исторической поэтики 21, no. 2 (2024): 207–28. http://dx.doi.org/10.15393/j9.art.2024.13622.

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The article introduces the classical ghazals in the poetry of Nimá Yushíj (1897–1960) that were previously unexamined in Russian and Western Iranian Studies, and that provided an impetus for the development of this traditional genre in the contemporary Persian literature. Analysis of the canonic language signs of medieval lyrics by the “father of Iranian new poetry’s” sheds light upon the transformation of the author’s self-awareness in line with the original artistic manner. Conventional images and stable motifs of love lyrics, which have absorbed traditional mystical and allegorical connot

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25

Opiela, Shannon Jacqueline, and Becky Adkins. "Exposure to NIMA-like alloantigens induces vigorous in vivo T cell responses in murine neonates (102.17)." Journal of Immunology 178, no. 1_Supplement (2007): S207. http://dx.doi.org/10.4049/jimmunol.178.supp.102.17.

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Abstract During early life, fetuses and neonates are exposed to allogeneic non-inherited maternal antigens (NIMA), through the passage of maternal cells and/or molecules across the placenta and in the breastmilk. Currently, it is thought that this early exposure results in the development of tolerance to NIMA. This is manifest in later life as an increased acceptance of grafts expressing the NIMA antigens. However, there also is evidence that exposure to NIMA during early life can lead to priming instead. In a murine model, we have shown that priming of neonates occurs when they are exposed to

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26

Yoshihara, Takao, Keiko Okada, Hiromasa Yabe, et al. "Outcome of Non-T-Cell-Depleted Hematopoietic Stem Cell Transplantation between HLA-Haploidentical Non-Inherited Maternal Antigen (NIMA)-Mismatched Family Members in Childhood." Blood 106, no. 11 (2005): 2913. http://dx.doi.org/10.1182/blood.v106.11.2913.2913.

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Abstract Sporadic cases of successful non-T-cell-depleted (TCD) hematopoietic stem cell transplantation (SCT) from HLA-haploidentical family members mismatched for noninherited maternal antigens (NIMAs) have been reported over the last few years. This kind of SCT is based on the hypothesis that long-term feto-maternal microchimerism is associated with acquired immunologic hyporesponsiveness to NIMA or inherited paternal antigens (IPAs). To confirm the effectiveness and safety of NIMA-mismatched SCT in a large cohort, we retrospectively surveyed the outcomes of 76 children (44 boys, 32 girls; m

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27

van Rood, Jon J., Cladd E. Stevens, Jacqueline Smits, Carmelita Carrier, Carol Carpenter, and Andromachi Scaradavou. "Re-Exposure of Cord Blood (CB) to Non-Inherited Maternal HLA Antigens (NIMA) Improves Transplant Outcome in Patients (pts) with Hematologic Malignancies and May Reduce Relapse." Blood 114, no. 22 (2009): 661. http://dx.doi.org/10.1182/blood.v114.22.661.661.

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Abstract Abstract 661 CB hematopoietic stem cell transplantation (CBT) can be successful even if donor and recipient are not fully matched for human leukocyte antigens (HLA). This may result, at least in part, from tolerance-inducing events during pregnancy, but this concept has not been tested to date. Hence we analyzed the impact of fetal exposure to NIMA of the HLA-A, -B antigens or -DRB1 alleles on the outcome of 1121 pts with hematologic malignancies. All pts received single CB units provided by the NYBC, for treatment of ALL (N=451), AML (N=376), CML (N=116), MDS (N=79), other (N=99); 22

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28

Xayitaliyeva, Azizaxon Bohodirjon qizi, Kumushbibi Jaxongir qizi Dumanova, and Ravshanbek Raxmonjon o'g'Li Ismoilov. "UMURTQASIZ HAYVONLAR." JOURNAL OF SCIENCE-INNOVATIVE RESEARCH IN UZBEKISTAN 1, no. 9 (2023): 194–97. https://doi.org/10.5281/zenodo.10289259.

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Biz bilamizki, bu sayyorada millionlab hayvonlar turlari mavjud. Ularning har biri kelib chiqishi va morfologiyasiga qarab har xil xususiyatlarga ega. Ko'pchilik yaxshi bilmaydi umurtqasiz hayvonlar nima va nima uchun ular ushbu toifaga kiritilgan. Shu sababli, biz ushbu maqolani sizga umurtqasiz hayvonlar nima, ularning xususiyatlari va ahamiyati haqida bilishimiz kerak bo'lgan hamma narsalar yoritib berilgan

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29

Krien, M. J., S. J. Bugg, M. Palatsides, G. Asouline, M. Morimyo, and M. J. O'Connell. "A NIMA homologue promotes chromatin condensation in fission yeast." Journal of Cell Science 111, no. 7 (1998): 967–76. http://dx.doi.org/10.1242/jcs.111.7.967.

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Entry into mitosis requires p34(cdc2), which activates downstream mitotic events through phosphorylation of key target proteins. In Aspergillus nidulans, the NIMA protein kinase has been identified as a potential downstream target and plays a role in regulating chromatin condensation at mitosis. nimA- mutants arrest in a state that physically resembles interphase even though p34(cdc2) is fully active. Despite evidence for the existence of NIMA-like activities in a variety of cell types, the only bona fide NIMA homologue that has been identified is the nim-1 gene of Neurospora crassa. We report

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Davies, Jonathan R., Aysha H. Osmani, Colin P. C. De Souza, Catherine Bachewich, and Stephen A. Osmani. "Potential Link between the NIMA Mitotic Kinase and Nuclear Membrane Fission during Mitotic Exit in Aspergillus nidulans." Eukaryotic Cell 3, no. 6 (2004): 1433–44. http://dx.doi.org/10.1128/ec.3.6.1433-1444.2004.

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ABSTRACT We have isolated TINC as a NIMA-interacting protein by using the yeast two-hybrid system and have confirmed that TINC interacts with NIMA in Aspergillus nidulans. The TINC-NIMA interaction is stabilized in the absence of phosphatase inhibitors and in the presence of kinase-inactive NIMA, suggesting that the interaction is enhanced when NIMA is not fully activated. TINC is a cytoplasmic protein. TINC homologues and a TINC-like protein (A. nidulans HETC) are conserved in other filamentous fungi. Neither deletion of tinC nor deletion of both tinC and A. nidulans hetC is lethal, but delet

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31

Mahjoub, Moe R., Ben Montpetit, Lifan Zhao, et al. "The FA2 gene of Chlamydomonas encodes a NIMA family kinase with roles in cell cycle progression and microtubule severing during deflagellation." Journal of Cell Science 115, no. 8 (2002): 1759–68. http://dx.doi.org/10.1242/jcs.115.8.1759.

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The NIMA kinases are one of several families of kinases that participate in driving the eukaryotic cell cycle. NIMA-related kinases have been implicated in G2/M progression, chromatin condensation and regulation of the centrosome cycle. Here we report the identification of a new member of this family, FA2, from Chlamydomonas reinhardtii. FA2 was originally discovered in a genetic screen for deflagellation-defective mutants. We have previously shown that FA2 is essential for basal-body/centriole-associated microtubule severing. We now report that the FA2 NIMA-related kinase also plays a role in

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32

O'rinboyev, Alisher Shavkatjon o'g'li. "INTERNET ASHYOLARINING ASOSIY TUSHUNCHALARI VA TA'RIFLARI." ZDIT 2, no. 23 (2023): 84–85. https://doi.org/10.5281/zenodo.8304228.

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33

Raximova, Altin Kadambayevna. "ONA TILI O'QITISH METODIKASI DARSLARIDA LEKSIKOLOGIYANI O'QITISHNING INNOVATSION USULLARI." Involta Innovation Scientific Journal 2, no. 9 (2023): 55–64. https://doi.org/10.5281/zenodo.10435992.

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Ona tili o‘qitish metodikasi darlarida leksikologiya bo’limini o'qitish metodikasini o‘quvchilarga innovatsion usullarini ushbu fan sohasi uchun zarur bo‘lgan ko‘nikma va bilimlarni egallashga yordam beradigan turli xil yondashuv va usullarni o‘z ichiga oladi. Ushbu maqolada biz ona tili darslarida leksikologiyani o‘qitishda qo‘llaniladigan asosiy usullar va ular nima uchun samarali ekanligini ko‘rib chiqamiz.

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Ofori-Attah, Ebenezer, Abigail Aning, Mark Ofosuhene, Justice Kumi, and Regina Appiah-Opong. "Determination of aflatoxin levels in bokina beverage." Ghana Medical Journal 55, no. 4 (2021): 292–97. http://dx.doi.org/10.4314/gmj.v55i4.10.

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Objective: The main aim of this study was to investigate levels of total aflatoxin and aflatoxin M1 in bokina, a homemade non-alcoholic beverage prepared from dairy milk, millet and sugar.Methods: Bokina, dairy milk and millet were purchased monthly over a period of 7 months from bokina producers at Ashaiman and Nima, in Ghana. Total aflatoxin and aflatoxin M1 levels in these samples were measured using a fluorometric procedure and High-Performance Liquid Chromatography.Results: Aflatoxin levels in bokina samples ranged from 1.0 to 21.0 ppb for Ashaiman samples and 1.0 to 23.0 ppb for Nima sam

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Swenson, Katherine I., Katharine E. Winkler, and Anthony R. Means. "A New Identity for MLK3 as an NIMA-related, Cell Cycle–regulated Kinase That Is Localized near Centrosomes and Influences Microtubule Organization." Molecular Biology of the Cell 14, no. 1 (2003): 156–72. http://dx.doi.org/10.1091/mbc.e02-02-0115.

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Although conserved counterparts for most proteins involved in the G2/M transition of the cell cycle have been found in all eukaryotes, a notable exception is the essential but functionally enigmatic fungal kinase NIMA. While a number of vertebrate kinases have been identified with catalytic domain homology to NIMA, none of these resemble NIMA within its extensive noncatalytic region, a region critical for NIMA function in Aspergillus nidulans. We used a bioinformatics approach to search for proteins with homology to the noncatalytic region of NIMA and identified mixed lineage kinase 3 (MLK3).

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Akramov, Xurshidbek Bahrom o'g'li. "BANK PLASTIK KARTALARI ORQALI TO'LOVLARNING RIVOJLANISHI HAMDA AHAMIYATI." INTERNATIONAL SCIENCES, EDUCATION AND NEW LEARNING TECHNOLOGIES 1, no. 6 (2024): 116–18. https://doi.org/10.5281/zenodo.11049946.

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<em>Ushbu maqolada plastik to‘lov kartalari vaqt o‘tishi bilan qanday o‘zgarganligi va nima uchun ular hozir juda muhim ekanligi ko‘rib chiqiladi. Unda ular qanday rivojlanganligi, odamlar ulardan qanday foydalanishi va nima uchun iqtisodiyot uchun muhimligi haqida gapiriladi. Ulardan foydalanish qulayligi, xavfsizligi va biznesga qanday yordam berishi kabi jihatlarni ko‘rib chiqsak, ushbu maqola plastik kartochkalar bugungi dunyoda nima uchun muhimligini tushunishga yordam beradi.</em>

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Pingel, Julia, Camila J. Hernandez Frederick, Tao Wang, et al. "Evaluation of the Impact of Non-Inherited Maternal Antigens on the Outcome of HLA Mismatched Unrelated Donor Hematopoietic Stem Cell Transplantation for Hematological Malignancies on Behalf of the ALWP of the EBMT and the CIBMTR." Blood 126, no. 23 (2015): 3226. http://dx.doi.org/10.1182/blood.v126.23.3226.3226.

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Abstract Allogeneic hematopoietic stem cell transplantation (HSCT) offers a potential cure for a variety of hematological malignancies. Patients without an HLA matched sibling donor can turn to unrelated donor registries to identify a suitably HLA matched donor. In the case where a fully HLA-A, -B, -C, -DRB1 and -DQB1 (10/10) matched donor is unavailable, there are often multiple 9/10 matched donors to select from. However, the prioritization and identification of permissive HLA mismatches in the 9/10 matched setting have proven elusive. Fetal exposure to non-inherited maternal antigens (NIMA)

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Ruiz-Sánchez, A., R. Cruz-Camarillo, R. Salcedo-Hernández, and J. E. Barboza-Corona. "Chitinases from Serratia marcescens Nima." Biotechnology Letters 27, no. 9 (2005): 649–53. http://dx.doi.org/10.1007/s10529-005-3661-1.

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Bozorov, Otabek Eshbo'ri o'g'li. "NIMA UCHUN CHUQUR O'RGANISH MUHIM." Journal of Universal Science Research 1, no. 6 (2023): 428–32. https://doi.org/10.5281/zenodo.8026053.

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Chuqur o'rganish - bu kompyuterlarni odamlarga tabiiy ravishda keladigan narsalarni qilishni o'rgatadigan mashinani o'rganish usuli: misol orqali o'rganing. Chuqur o'rganish haydovchisiz avtomobillar ortidagi asosiy texnologiya bo'lib, ularga to'xtash belgisini tanib olish yoki piyodani chiroq ustunidan farqlash imkonini beradi. Bu telefonlar, planshetlar, televizorlar va ovozli dinamiklar kabi iste'molchi qurilmalarida ovozli boshqaruvning kalitidir. So'nggi paytlarda chuqur o'rganishga katta e'tibor qaratilmoqda va buning sababi yaxshi. Bu ilgari i

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Ollayoro'va, Zulfiya Hoyitbayevna. ""OMMAVIY MADANIYAT" BIZGA NIMA BERMOQDA?" JOURNAL OF NEW CENTURY INNOVATIONS 1, no. 1 (2022): 183–91. https://doi.org/10.5281/zenodo.6396869.

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Annotatsiya;  Ushbu maqolada  bugungi  kundagi  “ommaviy  madaniyat”ning   kuchli  raqobat sharoitida  butun  dunyodagi  barcha  millatlarning jamiyatdagi  o’rni,   ro’li,  bir – birlari  bilan o’zaro  munosabatlarini  to’g’ri  faollashtirish  ilgari  surilgan   bo’lib,  telekanallar  orqali  namoyish  etilayotgan  qo’shiqlar,  kinolar,  te’atrlar   shuningdek  adabiyot  va &n

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Yaxshimuratova, Maftuna Ulug'bek qizi, and Rustam Abdurashidovich Toshtemirov. "AXBOROT NIMA VA UNING MANBALARI." SCHOLAR 1, no. 34 (2023): 144–48. https://doi.org/10.5281/zenodo.10411117.

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Mirxamzayeva, Feruzaxon Mirkomil qizi, and Rustam Abdurashidovich Toshtemirov. "AXBOROT NIMA VA UNING MANBALARI." SCHOLAR 1, no. 34 (2023): 533–38. https://doi.org/10.5281/zenodo.10413444.

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<em>Ushbu maqolada axborot tushunchasi toʻliq oʻrganiladi, uning taʼrifi tahlil qilinadi va uning turli manbalari oʻrganiladi. Maqsad axborotning tabiati va uning dunyomizni shakllantirishdagi roli haqidagi tushunchamizni kengaytirishdir.</em>

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Bobonazarov, Sherali Ulug'murodovich. "TASVIRLARNI GRIZAYL TEXNIKASIDA ISHLASHNING O'ZIGA XOSLIGI." Innovative Development in Educational Activities 1, no. 6 (2022): 114–18. https://doi.org/10.5281/zenodo.7452504.

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Grizayl qalamda kompozisiya chizish va bo‘yoq bilan ishlashda o‘ziga xos “ko‘prik” vazifasini o‘tab, bo‘lajak mutaxasislarning, yanada chuqurroq atroflicha bilim olishlarida asos bo‘la oladi. Bu usulda rasm ishlashning afzalligi shundaki, endigina tasviriy sanat sohasiga qo‘l urayotgan yosh avlod biror buyumni tasvirlar ekan tus nima, tonallik nima, hajm nima, axromatik va xromatik ranglarni qanday farqi bor va boshqa shunga o‘xshash savollarga javob topadi.

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44

Xudoynazarov, Umidjon Umarjon o'g'li, and Shaxzodbek Ma'murjon o'g'li Yetmishboyev. "STUXSNET, FLAME, WIPER ZARARLI DASTURLARI HAQIDA MA'LUMOTLAR." Results of National Scientific Research 1, no. 9 (2022): 144–50. https://doi.org/10.5281/zenodo.7467436.

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stuxsnet, flame, wiper zararli dasturlari haqida tezisida zararli dasturlarni qayerda va qanday kashf etilishi hamda nima sababdan ishlab chiqarilgani bundan tashqari ularning nima maqsadda qo‘llanishi haqida gap boradi.

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Morse, Corinne S., Robert K. Goodrich, and Larry B. Cornman. "The NIMA Method for Improved Moment Estimation from Doppler Spectra." Journal of Atmospheric and Oceanic Technology 19, no. 3 (2002): 274–95. http://dx.doi.org/10.1175/1520-0426-19.3.274.

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Abstract The NCAR Improved Moments Algorithm (NIMA) for estimating moments from wind measurement devices that measure Doppler spectra as a function of range is described in some detail. Although NIMA's main application has been for real-time processing of wind profiler data, it has also been successfully applied to Doppler lidar and weather radar data. Profiler spectra are often contaminated by a variety of sources including aircraft, birds, velocities exceeding the Nyquist velocity, radio frequency interference, and ground clutter. The NIMA method uses mathematical analysis, fuzzy logic synth

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46

Sarvinoz, Shokirova Isroiljon qizi, and Odilova Hamida. "ZAHIRIDDIN MUHAMMAD BOBURNING AVLODLARI "KO'HINUR" OLMOSI HAQIDA BILISHADIMI?" GOLDEN BRAIN 1, no. 11 (2023): 329–32. https://doi.org/10.5281/zenodo.7865921.

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<em>Ushbu maqola odamlar Ko‘hinur olmosi haqida nima bilishi va nima uchun odamlar “Ko‘hinur” nomini eshitganda go‘zallik saloni yoki tanaddixonalar tushunishi haqida.</em>

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47

Wang, Yu, Xiang-Yu Zhao, Lan-Ping Xu, et al. "Lower Incidence of Acute Gvhd Is Associated with the Rapid Recovery of CD4+CD25+CD45RA+ Regulatory T Cells in Patients Who Received Haploidentical Allografts from NIMA-Mismatched Donors: A Retrospective (development) and Prospective (validation) Cohort-Based Study." Blood 128, no. 22 (2016): 4573. http://dx.doi.org/10.1182/blood.v128.22.4573.4573.

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Abstract To investigate the effects of non-inherited maternal antigen (NIMA) on clinical outcomes and immune recovery, especially of regulatory T cells (Tregs), in patients who underwent unmanipulated haploidentical transplantation.A retrospective cohort (n=57) and a prospective cohort (n=88) were included. Reconstitution of immune subsets, including Tregs, was determined using multicolor flow cytometry. In the retrospective cohort, the cumulative incidence of grades II-IV acute GVHD in patients with NIMA-mismatched donors was significantly lower than that of cases with NIPA-mismatched donors

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Ganjewala, Deepak. "Effects of sodium nitroprusside activity of acid and alkaline invertases and alkaline phosphatase in lemongrass (Cymbopogon flexuosus Steud) Wats." International Journal of Plant Biology 1, no. 1 (2010): 2. http://dx.doi.org/10.4081/pb.2010.e2.

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Here we report the effects of SNP, a nitric oxide donor on sucrose metabolizing enzymes, acid and alkaline invertase (EC 3.2.1.26 and 3.2.1.153) and ubiquitous alkaline phosphatase (EC 3.1.3.1) in four lemongrass varieties viz., Krishna, Cauveri, Nima and Cheerharit. For the study, two 15 d lemongrass tillers were cut and immediately dipped into the test tubes containing SNP solution (5 mL) of variable strength (1 to 5 mM) and one without SNP (as control); kept for 4 h under mild sunlight. The results revealed that moderate SNP concentration (2 mM) was most effective, caused drastic reduction

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Shen, Kuo-Fang, Aysha H. Osmani, Meera Govindaraghavan, and Stephen A. Osmani. "Mitotic regulation of fungal cell-to-cell connectivity through septal pores involves the NIMA kinase." Molecular Biology of the Cell 25, no. 6 (2014): 763–75. http://dx.doi.org/10.1091/mbc.e13-12-0718.

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Intercellular bridges are a conserved feature of multicellular organisms. In multicellular fungi, cells are connected directly via intercellular bridges called septal pores. Using Aspergillus nidulans, we demonstrate for the first time that septal pores are regulated to be opened during interphase but closed during mitosis. Septal pore–associated proteins display dynamic cell cycle–regulated locations at mature septa. Of importance, the mitotic NIMA kinase locates to forming septa and surprisingly then remains at septa throughout interphase. However, during mitosis, when NIMA transiently locat

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Yangiboyev, Umid Abdurashid o'g'li. "XML TEXNOLOGIYASI ASOSIDA VIRTUAL DARSLIK YARATISH." EURASIAN JOURNAL OF MATHEMATICAL THEORY AND COMPUTER SCIENCES 3, no. 4 (2023): 76–84. https://doi.org/10.5281/zenodo.7874764.

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Ehtimol, siz XML haqida eshitgansiz va sizning tashkilotingizda uni ishlatishning ko'plab o’ziga xos sabablarini aniqlagansiz. Ammo XML aniq nima? Ushbu mustaqil ishda XML nima ekanligini va u qanday ishlashini tushuntirib o’tiladi.

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