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Relevant bibliographies by topics / Nimbolide

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Academic literature on the topic 'Nimbolide'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Nimbolide"

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Dangwal, Pranshu, Saransh Juyal, Arun Bhatt, Mamta Baunthiyal, and Dev Bukhsh Singh. "Molecular docking and simulation analysis of nimbolide with poly-galacturonase from Aspergillus niger: Managing black mold disease for Allium cepa." Bioinformation 21, no. 05 (2025): 1050–56. https://doi.org/10.6026/973206300211050.

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Black mold disease is a major post-harvest issue in Allium cepa caused by Aspergillus niger. Therefore, it is of interest to describe the molecular docking and simulation analysis of poly-galacturonase protein from Aspergillus Niger that is involved in disease progression as a promising molecular target for the identification of novel fungicides. Hence, we used I-TASSER to model the protein and docked it with the naturally occurring phytoalexins, which included nimbolide, nimbolin, Azadiradione, Quercetin and Azadirone. We show that nimbolide has the greatest affinity towards poly-galacturonas

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Shin, Seung-Shick, Byungdoo Hwang, Kashif Muhammad, et al. "Nimbolide Represses the Proliferation, Migration, and Invasion of Bladder Carcinoma Cells via Chk2-Mediated G2/M Phase Cell Cycle Arrest, Altered Signaling Pathways, and Reduced Transcription Factors-Associated MMP-9 Expression." Evidence-Based Complementary and Alternative Medicine 2019 (July 14, 2019): 1–12. http://dx.doi.org/10.1155/2019/3753587.

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Nimbolide, an active chemical constituent of Azadirachta indica, reportedly has several physiological effects. Here, we assessed novel anticancer effects of nimbolide against bladder cancer EJ and 5637 cells. Nimbolide treatment inhibited the proliferation of both bladder cancer cell lines with an IC50 value of 3 μM. Treatment of cells with nimbolide induced G2/M phase cell cycle arrest via both Chk2-Cdc25C-Cdc2/cyclin B1-Wee1 pathway and Chk2-p21WAF1-Cdc2/cyclin B1-Wee1 pathway. Nimbolide increased JNK phosphorylation and decreased p38MAPK and AKT phosphorylation. Additionally, nimbolide impe

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Lee, Jung-Eun, and Dong-Soon Im. "Inhibitory Effect of Nimbolide on Mast Cell Degranulation and Allergic Asthma in Mice." Yakhak Hoeji 66, no. 5 (2022): 217–24. http://dx.doi.org/10.17480/psk.2022.66.5.217.

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The Indian neem tree has been used for treating several medical conditions. Nimbolide, an active compound present in the leaves of the Indian neem tree, has shown anti-inflammatory effects in several animal models. However, its efficacy against allergic asthma has not been examined. Therefore, we investigated the effects of nimbolide on mast cell degranulation and ovalbumin-induced allergic asthma in mice. Nimbolide administration inhibited antigen-induced degranulation of RBL-2H3 cells in a concentration-dependent manner and reduced the immune cell numbers by suppressing the expression of inf

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Dhanya, S. R., S. Nishanth Kumar, Vandana Sankar, K. G. Raghu, B. S. Dileep Kumar, and Mangalam S. Nair. "Nimbolide from Azadirachta indica and its derivatives plus first-generation cephalosporin antibiotics: a novel drug combination for wound-infecting pathogens." RSC Advances 5, no. 109 (2015): 89503–14. http://dx.doi.org/10.1039/c5ra16071e.

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We evaluate the in vitro efficacy of nimbolide, desacetylnimbin, and the amide derivatives of nimbolide in combination with first-generation cephalosporin antibiotics against major wound-associated bacterial pathogens.

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Suttiarporn, Panawan, and Vachira Choommongkol. "Microwave-Assisted Improved Extraction and Purification of Anticancer Nimbolide from Azadirachta indica (Neem) Leaves." Molecules 25, no. 12 (2020): 2913. http://dx.doi.org/10.3390/molecules25122913.

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Nimbolide, a limonoid present in leaves of the neem tree (Azadirachta indica), is an anticancer compound against a panel of human cancer cell lines. The rapid process of extraction and purification of the nimbolide from the leaves of neem tree through microwave-assisted extraction (MAE) coupled with a chromatographic technique was accomplished. The crude with a maximum content of nimbolide could be recovered from neem leaves through MAE. By using three-factors, three-level Box–Behnken design of response surface methodology (RSM), the optimal conditions for nimbolide extraction (R2 = 0.9019) we

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Wang, Lingzhi, Do-Dang Phan, Nicholas Syn, et al. "A Sensitive Liquid Chromatography-Tandem Mass Spectrometry Method for the Determination of Nimbolide in Mouse Serum: Application to a Preclinical Pharmacokinetics Study." Pharmaceutics 10, no. 3 (2018): 123. http://dx.doi.org/10.3390/pharmaceutics10030123.

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A sensitive and robust liquid chromatography-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the determination of nimbolide in mouse serum. Exemestane was used as the internal standard (IS). Here, we employed acetonitrile-based protein precipitation (PPT) for serum sample preparation, and performed chromatographic separation using an ODS Hypersil C18 column (100 mm × 2.1 mm, 5 µm) with gradient elution (0.1% formic acid in water vs 100% acetonitrile). The run time was 6 min. Instrumental analysis was performed by electrospray ionization tandem mass spectrometry (ESI

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Anitha, G., J. Josepha Lourdu Raj, S. Narasimhan, K. Anand Solomon, and S. S. Rajan. "Nimbolide and isonimbolide." Journal of Asian Natural Products Research 8, no. 5 (2006): 445–49. http://dx.doi.org/10.1080/10286020500173267.

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Li, Peng, Yuanli Zhen, Chiho Kim, et al. "Abstract PR002: Nimbolide targets RNF114 to induce the trapping of PARP1 and synthetic lethality in BRCA-mutated cancer." Molecular Cancer Therapeutics 23, no. 6_Supplement (2024): PR002. http://dx.doi.org/10.1158/1538-8514.synthleth24-pr002.

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Abstract Despite the tremendous success of PARP1 inhibitors (PARPi) for the treatment of BRCA mut tumors, intrinsic and acquired resistance to PARPi remains a critical challenge in the clinic. This is, at least in part, due to the incomplete understanding of the mechanism of action (MoA) of PARPi. Recent studies from both our lab and others have pointed to PARP1 trapping as a key determinant of the anticancer effects of PARP1 inhibitors (PARPi). However, the molecular underpinnings of PARP1 trapping are poorly understood. Here we performed a proteomics-based chromatin relocalization screen, an

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Zhang, Tianchan, Xumeng Gu, Juan Du, Yang Yu, and Huifang Cong. "Nimbolide as a bioactive compound in food science: inhibition of proliferation and glycolysis in endometriosis cells." Italian Journal of Food Science 37, no. 2 (2025): 241–51. https://doi.org/10.15586/ijfs.v37i2.2948.

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Endometriosis is a common gynecological disorder characterized by the ectopic growth of endometrial-like tis-sue, often leading to chronic pain and infertility. Despite its high prevalence, the underlying mechanisms are still poorly understood. Nimbolide, a bioactive compound derived from Azadirachta indica (neem), has been shown to possess various biological activities, including anti-malarial, anti-inflammatory, and anti-cancer prop-erties. However, its effects on endometriosis have largely remained unexplored. Human endometriosis cell lines (End1/E6E7) were cultured and treated with varying

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NT, Chaitra, Ravindranath H. Aladakatti, and Nandeshwarappa B P. "Effect of nimbolide on rat spermatozoa under in-vitro condition: A study on sperm functional events and antioxidants during capacitation." Journal of Laboratory Animal Science 7, no. 1 (2024): 10–23. https://doi.org/10.48165/jlas.2024.7.1.3.

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However, little evidence has been documented to evaluate the clear specific effects of neem-active ingredients in a rat model. This study aims to evaluate the in vitro effects of nimbolide (tetranortriterpenoids group, one of the main components of neem leaves), particularly on sperm functional studies, and biochemical and molecular events during capacitation in a dose dependent manner. The results showed a dose- and time-dependent decrease in the functional consequence of capacitation process i.e., motility score, percentage of motile spermatozoa, Sperm Motility Index (SMI) and levels of mole

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Dissertations / Theses on the topic "Nimbolide"

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Karkare, Swagata. "Direct inhibition of Retinoblastoma phosphorylation by Nimbolide causes cell cycle arrest and suppresses Glioblastoma growth." University of Cincinnati / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1380613326.

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Lin, Jia-Ying, and 林家瑩. "Study on the Nimbolide inhibit the proliferation and invasion on the renal cancer cells." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/63845960913488963769.

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碩士<br>中山醫學大學<br>生化暨生物科技研究所<br>102<br>Cancer is the top of ten causes of death in Taiwan, especially renal cell carcinoma (RCC) is the third leading cause of death among urological tumours. The metastasisof cancer cells leads 30% patients died, and inhibition of cancer cells metastasis will markly decrease the death rate. Therefore, development of novel nature drug or drug therapy was important topic. Nimbolide was first derived from the leaves and flowers of neem (Azadirachta indica), a tree in the mahogany family. Nimbolide is a a wide range of pharmacological properties including anti-metast

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Book chapters on the topic "Nimbolide"

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Siddavaram, Nagini, and Vidya Priyadarsini Ramamurthi. "Apoptosis Induction by Nimbolide, a Limonoid from Azadirachta indica: Molecular Targets and Signaling Networks." In Novel Apoptotic Regulators in Carcinogenesis. Springer Netherlands, 2012. http://dx.doi.org/10.1007/978-94-007-4917-7_2.

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Conference papers on the topic "Nimbolide"

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Zhang, Jingwen, Muthu K. Shanmugam, Amudha Deivasigamani, Alan P. Kumar, Kam M. Hui, and Gautam Sethi. "Abstract 677: Possible role of nimbolide in prevention and therapy of prostate cancer." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-677.

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Pandian, V., M. Natarajan, S. Aravindan, TS Herman, and N. Aravindan. "Abstract P6-09-05: Neem leaf extract, rich in nimbolide and azadirachtin targets radiation-induced stemness in surviving breast cancer cells." In Abstracts: Thirty-Sixth Annual CTRC-AACR San Antonio Breast Cancer Symposium - Dec 10-14, 2013; San Antonio, TX. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/0008-5472.sabcs13-p6-09-05.

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