Relevant bibliographies by topics / NIR-II biological window

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Academic literature on the topic 'NIR-II biological window'

Author: Grafiati
Published: 4 June 2025
Last updated: 23 June 2025

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Journal articles on the topic "NIR-II biological window"

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Zhu, Shoujun, Qinglai Yang, Alexander L. Antaris, et al. "Molecular imaging of biological systems with a clickable dye in the broad 800- to 1,700-nm near-infrared window." Proceedings of the National Academy of Sciences 114, no. 5 (2017): 962–67. http://dx.doi.org/10.1073/pnas.1617990114.

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Fluorescence imaging multiplicity of biological systems is an area of intense focus, currently limited to fluorescence channels in the visible and first near-infrared (NIR-I; ∼700–900 nm) spectral regions. The development of conjugatable fluorophores with longer wavelength emission is highly desired to afford more targeting channels, reduce background autofluorescence, and achieve deeper tissue imaging depths. We have developed NIR-II (1,000–1,700 nm) molecular imaging agents with a bright NIR-II fluorophore through high-efficiency click chemistry to specific molecular antibodies. Relying on buoyant density differences during density gradient ultracentrifugation separations, highly pure NIR-II fluorophore-antibody conjugates emitting ∼1,100 nm were obtained for use as molecular-specific NIR-II probes. This facilitated 3D staining of ∼170-μm histological brain tissues sections on a home-built confocal microscope, demonstrating multicolor molecular imaging across both the NIR-I and NIR-II windows (800–1,700 nm).
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Zhou, Rui, Zheng Wei Wu, Zhan Hui Sun, and Xiao Fei Su. "Synthesis of Long Gold Nanorods as an Efficient Photothermal Agent in the Second Near-Infrared Window." Journal of Nano Research 40 (March 2016): 180–89. http://dx.doi.org/10.4028/www.scientific.net/jnanor.40.180.

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To date, intensive efforts have been devoted in the synthesis of various nanomaterials as photothermal agent in the first near-infrared (NIR) window (650-950 nm). Although the NIR-II window (1000-1350 nm) is recognized to offer more efficient tissue penetration and higher permissible exposure to excitation light, the corresponding photothermal agents have been scant. Here, we report a binary surfactant seeded growth method for high yield synthesis of long AuNRs (LAuNRs) as an efficient NIR-II photothermal agent. The as-synthesized LAuNRs with aspect ratio of 6.7 shows strong surface plasmon resonance band at 1064 nm, and demonstrates high photothermal conversion efficiency and excellent photothermal stability. When the AuNRs aqueous dispersion is covered with a 6 mm thick pork tissue as a model of biological tissues, its temperature can still be increased by 13.1 °C under a 1064 nm 1.0 W/cm2 laser irradiation. These results demonstrate the promising potential of the LAuNRs as an efficient photothermal agent in the NIR-II window.
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Yu, Zhen-feng, Jun-peng Shi, Jin-lei Li, Peng-hui Li, and Hong-wu Zhang. "Luminescence enhancement of CaF2:Nd3+nanoparticles in the second near-infrared window forin vivoimaging through Y3+doping." Journal of Materials Chemistry B 6, no. 8 (2018): 1238–43. http://dx.doi.org/10.1039/c7tb03052e.

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Shi, Yifeng, Shiyi Peng, Zhongyu Huang, et al. "Gold-Nanorod-Assisted Live Cell Nuclear Imaging Based on Near-Infrared II Dark-Field Microscopy." Biology 12, no. 11 (2023): 1391. http://dx.doi.org/10.3390/biology12111391.

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Dark-field microscopy offers several advantages, including high image contrast, minimal cell damage, and the absence of photobleaching of nanoprobes, which make it highly advantageous for cell imaging. The NIR-II window has emerged as a prominent research focus in optical imaging in recent years, with its low autofluorescence background in biological samples and high imaging SBR. In this study, we initially compared dark-field imaging results of colorectal cancer cells in both visible and NIR-II wavelengths, confirming the superior performance of NIR-II imaging. Subsequently, we synthesized gold nanorods with localized surface plasmon resonance (LSPR) absorption peaks in the NIR-II window. After bio-compatible modification, we non-specifically labeled colorectal cancer cells for NIR-II dark-field scattering imaging. The imaging results revealed a sixfold increase in SBR, especially in the 1425–1475 nm wavelength range. Finally, we applied this imaging system to perform dark-field imaging of cell nuclei in the NIR-II region and used GNRs for specific nuclear labeling in colorectal cancer cells. The resulting images exhibited higher SBR than non-specifically-labeled cell imaging, and the probe’s labeling was precise, confirming the potential application of this system in photothermal therapy and drug delivery for cancer cells.
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Sakiyama, Makoto, Hiroshi Sugimoto, and Minoru Fujii. "Long-lived luminescence of colloidal silicon quantum dots for time-gated fluorescence imaging in the second near infrared window in biological tissue." Nanoscale 10, no. 29 (2018): 13902–7. http://dx.doi.org/10.1039/c8nr03571g.

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He, Shuqing, Jun Song, Junle Qu, and Zhen Cheng. "Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics." Chemical Society Reviews 47, no. 12 (2018): 4258–78. http://dx.doi.org/10.1039/c8cs00234g.

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Recent advances in the chemical design and synthesis of fluorophores in the second near-infrared biological window (NIR-II) for multimodal imaging and theranostics are summarized and highlighted in this review article.
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Ren, Feng, Tuanwei Li, Tingfeng Yao, Guangcun Chen, Chunyan Li, and Qiangbin Wang. "Near-Infrared-II Fluorophores for In Vivo Multichannel Biosensing." Chemosensors 11, no. 8 (2023): 433. http://dx.doi.org/10.3390/chemosensors11080433.

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The pathological process involves a range of intrinsic biochemical markers. The detection of multiple biological parameters is imperative for providing precise diagnostic information on diseases. In vivo multichannel fluorescence biosensing facilitates the acquisition of biochemical information at different levels, such as tissue, cellular, and molecular, with rapid feedback, high sensitivity, and high spatiotemporal resolution. Notably, fluorescence imaging in the near-infrared-II (NIR-II) window (950–1700 nm) promises deeper optical penetration depth and diminished interferential autofluorescence compared with imaging in the visible (400–700 nm) and near-infrared-I (NIR-I, 700–950 nm) regions, making it a promising option for in vivo multichannel biosensing toward clinical practice. Furthermore, the use of advanced NIR-II fluorophores supports the development of biosensing with spectra-domain, lifetime-domain, and fluorescence-lifetime modes. This review summarizes the versatile designs and functions of NIR-II fluorophores for in vivo multichannel biosensing in various scenarios, including biological process monitoring, cellular tracking, and pathological analysis. Additionally, the review briefly discusses desirable traits required for the clinical translation of NIR-II fluorophores such as safety, long-wavelength emission, and clear components.
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Dang, Xiangnan, Li Gu, Jifa Qi, et al. "Layer-by-layer assembled fluorescent probes in the second near-infrared window for systemic delivery and detection of ovarian cancer." Proceedings of the National Academy of Sciences 113, no. 19 (2016): 5179–84. http://dx.doi.org/10.1073/pnas.1521175113.

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Fluorescence imaging in the second near-infrared window (NIR-II, 1,000–1,700 nm) features deep tissue penetration, reduced tissue scattering, and diminishing tissue autofluorescence. Here, NIR-II fluorescent probes, including down-conversion nanoparticles, quantum dots, single-walled carbon nanotubes, and organic dyes, are constructed into biocompatible nanoparticles using the layer-by-layer (LbL) platform due to its modular and versatile nature. The LbL platform has previously been demonstrated to enable incorporation of diagnostic agents, drugs, and nucleic acids such as siRNA while providing enhanced blood plasma half-life and tumor targeting. This work carries out head-to-head comparisons of currently available NIR-II probes with identical LbL coatings with regard to their biodistribution, pharmacokinetics, and toxicities. Overall, rare-earth-based down-conversion nanoparticles demonstrate optimal biological and optical performance and are evaluated as a diagnostic probe for high-grade serous ovarian cancer, typically diagnosed at late stage. Successful detection of orthotopic ovarian tumors is achieved by in vivo NIR-II imaging and confirmed by ex vivo microscopic imaging. Collectively, these results indicate that LbL-based NIR-II probes can serve as a promising theranostic platform to effectively and noninvasively monitor the progression and treatment of serous ovarian cancer.
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Ji, Shengjiao, Yuying Du, Jiancai Leng, Yujin Zhang, and Wei Hu. "Planar-Twisted Molecular Engineering for Modulating the Fluorescence Brightness of NIR-II Fluorophores with a Donor–Acceptor–Donor Skeleton." International Journal of Molecular Sciences 25, no. 22 (2024): 12365. http://dx.doi.org/10.3390/ijms252212365.

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Organic molecular fluorophores have been extensively utilized for biological imaging in the visible and the first near-infrared windows. However, their applications in the second near-infrared (NIR-II) window remain constrained, primarily due to the insufficient fluorescence brightness. Herein, we employ a theoretical protocol combining the thermal vibration correlation function with the time-dependent density functional theory method to investigate the mechanism of the planar-twisted strategy for developing fluorophores with balanced NIR-II emission and fluorescence brightness. Based on a planar donor–acceptor–donor molecular skeleton, various ortho-positioned alkyl side chains with steric hindrances are tactfully incorporated into the backbone to construct a series of twisted fluorophores. Photophysical characterizations of the studied fluorophores demonstrate that the emission spectra located in the NIR-II region exhibited a hypsochromic shift with the structural distortion. Notably, conformational twisting significantly accelerated the radiative decay rate while simultaneously suppressing the nonradiative decay rate, resulting in an improved fluorescence quantum efficiency (FQE). This enhancement can be mainly attributed to both the enlarged adiabatic excitation energy and reduced nonadiabatic electronic coupling between the first excited state and the ground state. Compared with the planar fluorophore, the twisted structures possessed a more than fivefold increase in FQE. In particular, the optimal twisted fluorophore BBTD-4 demonstrated a desirable fluorescence brightness (16.59 M−1 cm−1) on the premise of typical NIR-II emission (980 nm), making it a promising candidate for NIR-II fluorescence imaging in biomedical applications. The findings in this study elucidate the available experimental observations on the analogues, highlighting a feasible approach to modulating the photophysical performances of NIR-II chromophores for developing more highly efficient fluorophores toward optical imaging applications.
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Yang, Qinglai, Zhuoran Ma, Huasen Wang, et al. "Rational Design of Molecular Fluorophores for Biological Imaging in the NIR-II Window." Advanced Materials 29, no. 12 (2017): 1605497. http://dx.doi.org/10.1002/adma.201605497.

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Conference papers on the topic "NIR-II biological window"

1

Dai, Hongjie. "Biological fluorescence/luminescence imaging in the 1000-1700 nm NIR-II/SWIR Window." In Nanoscale Imaging, Sensing, and Actuation for Biomedical Applications XIX, edited by Dror Fixler, Sebastian Wachsmann-Hogiu, and Ewa M. Goldys. SPIE, 2022. http://dx.doi.org/10.1117/12.2627981.

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