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Journal articles on the topic 'Nitrite Stress'

Author: Grafiati

Published: 6 September 2023

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1

Karwowska, Małgorzata, and Anna Kononiuk. "Nitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits." Antioxidants 9, no. 3 (2020): 241. http://dx.doi.org/10.3390/antiox9030241.

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In the context of impact on human health, nitrite/nitrate and related nitrogen species such as nitric oxide (NO) are a matter of increasing scientific controversy. An increase in the content of reactive nitrogen species may result in nitrosative stress—a deleterious process, which can be an important mediator of damage to cell structures, including lipids, membranes, proteins and DNA. Nitrates and nitrites are widespread in the environment and occur naturally in foods of plant origin as a part of the nitrogen cycle. Additionally, these compounds are used as additives to improve food quality an

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2

Rajeev, Lara, Amy Chen, Alexey E. Kazakov, et al. "Regulation of Nitrite Stress Response in Desulfovibrio vulgaris Hildenborough, a Model Sulfate-Reducing Bacterium." Journal of Bacteriology 197, no. 21 (2015): 3400–3408. http://dx.doi.org/10.1128/jb.00319-15.

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ABSTRACTSulfate-reducing bacteria (SRB) are sensitive to low concentrations of nitrite, and nitrite has been used to control SRB-related biofouling in oil fields.Desulfovibrio vulgarisHildenborough, a model SRB, carries a cytochromec-type nitrite reductase (nrfHA) that confers resistance to low concentrations of nitrite. The regulation of this nitrite reductase has not been directly examined to date. In this study, we show that DVU0621 (NrfR), a sigma54-dependent two-component system response regulator, is the positive regulator for this operon. NrfR activates the expression of thenrfHAoperon

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Stojanović, Nikola M., Pavle J. Randjelović, Dragana Pavlović, et al. "An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress-Related Parameters." Oxidative Medicine and Cellular Longevity 2021 (January 7, 2021): 1–8. http://dx.doi.org/10.1155/2021/6635310.

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Both oxidative and psychological (mental) stress are the likely culprits for several acute and chronic health disturbances, and adequate tests mimicking that are needed. Herein, in controlled laboratory surroundings, a PEBL (Psychology Experiment Building Language) test battery was used to evoke stress-related biological responses followed by tracking changes in saliva parameters. The study objectives were to determine the impact of psychological stress on selected salivatory parameters and to assess the correlation between the determined oxidative and stress parameters. The study was conducte

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Stojanović, Nikola M., Pavle J. Randjelović, Dragana Pavlović, et al. "An Impact of Psychological Stress on the Interplay between Salivary Oxidative Stress and the Classic Psychological Stress-Related Parameters." Oxidative Medicine and Cellular Longevity 2021 (January 7, 2021): 1–8. http://dx.doi.org/10.1155/2021/6635310.

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Both oxidative and psychological (mental) stress are the likely culprits for several acute and chronic health disturbances, and adequate tests mimicking that are needed. Herein, in controlled laboratory surroundings, a PEBL (Psychology Experiment Building Language) test battery was used to evoke stress-related biological responses followed by tracking changes in saliva parameters. The study objectives were to determine the impact of psychological stress on selected salivatory parameters and to assess the correlation between the determined oxidative and stress parameters. The study was conducte

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5

De Luca, Chiara, Agnese Gugliandolo, Carlo Calabrò, et al. "Role of Polymorphisms of Inducible Nitric Oxide Synthase and Endothelial Nitric Oxide Synthase in Idiopathic Environmental Intolerances." Mediators of Inflammation 2015 (2015): 1–10. http://dx.doi.org/10.1155/2015/245308.

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Oxidative stress and inflammation play a pathogenetic role in idiopathic environmental intolerances (IEI), namely, multiple chemical sensitivity (MCS), fibromyalgia (FM), and chronic fatigue syndrome (CFS). Given the reported association of nitric oxide synthase (NOS) gene polymorphisms with inflammatory disorders, we aimed to investigate the distribution of NOS2A −2.5 kb (CCTTT)nas well as Ser608Leu and NOS3 −786T>C variants and their correlation with nitrite/nitrate levels, in a study cohort including 170 MCS, 108 suspected MCS (SMCS), 89 FM/CFS, and 196 healthy subjects. Patients and con

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6

Förster, Moritz, Christopher Nelke, Saskia Räuber, et al. "Nitrosative Stress Molecules in Multiple Sclerosis: A Meta-Analysis." Biomedicines 9, no. 12 (2021): 1899. http://dx.doi.org/10.3390/biomedicines9121899.

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Multiple sclerosis (MS) is an immune-mediated disease of the central nervous system of unknown etiology. As it is still a diagnosis of exclusion, there is an urgent need for biomarkers supporting its diagnosis. Increasing evidence suggests that nitrosative stress may play a pivotal role in the pathogenesis of MS. However, previous reports supporting the role of nitrosative stress molecules as disease biomarkers are inconsistent overall. We therefore systematically analyzed the existing literature to compare the serum and cerebrospinal fluid (CSF) levels of nitrite/nitrate in MS patients with t

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Gruber, H.-J., C. Bernecker, A. Lechner, et al. "Increased nitric oxide stress is associated with migraine." Cephalalgia 30, no. 4 (2009): 486–92. http://dx.doi.org/10.1111/j.1468-2982.2009.01964.x.

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Nitric oxide (NO) has been implicated in migraine attacks, but the role of NO in migraine remains unclear. We here hypothesize that increased NO in the headache-free period is associated with migraine. One hundred and thirty probands participated in this study. Various parameters of the NO pathway, such as nitrate, nitrite, arginine, citrulline, nitrosylated proteins, asymmetric dimethylarginine, symmetrical dimethylarginine, expression of endothelial nitric oxide synthase (eNOS) and inducible nitric oxide synthase and two polymorphisms of eNOS were investigated. We found significant increased

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8

Kern, Melanie, Christine Winkler та Jörg Simon. "Respiratory nitrogen metabolism and nitrosative stress defence in ϵ-proteobacteria: the role of NssR-type transcription regulators". Biochemical Society Transactions 39, № 1 (2011): 299–302. http://dx.doi.org/10.1042/bst0390299.

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ϵ-Proteobacteria form a globally ubiquitous group of ecologically significant organisms and comprise a diverse range of host-associated and free-living species. To grow by anaerobic respiration, many ϵ-proteobacteria reduce nitrate to nitrite followed by either nitrite ammonification or denitrification. Using the ammonifying model organisms Wolinella succinogenes and Campylobacter jejuni, the electron transport chains of nitrate respiration, respiratory nitrite ammonification and even N2O (nitrous oxide) respiration have been characterized in recent years, but knowledge on nitrosative stress d

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9

Sun, Dong, An Huang, Ellen H. Yan, et al. "Reduced release of nitric oxide to shear stress in mesenteric arteries of aged rats." American Journal of Physiology-Heart and Circulatory Physiology 286, no. 6 (2004): H2249—H2256. http://dx.doi.org/10.1152/ajpheart.00854.2003.

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We hypothesized that aging is characterized by a reduced release of nitric oxide (NO) in response to shear stress in resistance vessels. Mesenteric arterioles and arteries of young (6 mo) and aged (24 mo) male Fischer 344 rats were isolated and cannulated. Shear stress (15 dyn/cm2)-induced dilation was significantly reduced and shear stress (1, 5, 10, and 15 dyn/cm2)-induced increases in perfusate nitrite were significantly smaller at all shear stress levels in vessels of aged rats. Inhibition of NO synthesis abolished shear stress-induced release of nitrite. Furthermore, shear stress (15 dyn/

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10

Liu, Jianfeng, Jiao Yin, Yanshuang Li, et al. "High nitrite–nitrogen stress intensity drives nitrite anaerobic oxidation to nitrate and inhibits methanogenesis." Science of The Total Environment 832 (August 2022): 155109. http://dx.doi.org/10.1016/j.scitotenv.2022.155109.

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11

Cordero-Herrera, Isabel, Mikael Kozyra, Zhengbing Zhuge, et al. "AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis." Proceedings of the National Academy of Sciences 116, no. 1 (2018): 217–26. http://dx.doi.org/10.1073/pnas.1809406115.

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Advanced age and unhealthy dietary habits contribute to the increasing incidence of obesity and type 2 diabetes. These metabolic disorders, which are often accompanied by oxidative stress and compromised nitric oxide (NO) signaling, increase the risk of adverse cardiovascular complications and development of fatty liver disease. Here, we investigated the therapeutic effects of dietary nitrate, which is found in high levels in green leafy vegetables, on liver steatosis associated with metabolic syndrome. Dietary nitrate fuels a nitrate–nitrite–NO signaling pathway, which prevented many features

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12

Raat, Nicolaas J. H., Audrey C. Noguchi, Virginia B. Liu, et al. "Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response." Free Radical Biology and Medicine 47, no. 5 (2009): 510–17. http://dx.doi.org/10.1016/j.freeradbiomed.2009.05.015.

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13

Nebl, Josefine, Kathrin Drabert, Sven Haufe, et al. "Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns." Nutrients 11, no. 8 (2019): 1875. http://dx.doi.org/10.3390/nu11081875.

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This study investigated the exercise-induced changes in oxidative stress, nitric oxide (NO) metabolism and amino acid profile in plasma of omnivorous (OMN, n = 25), lacto-ovo-vegetarian (LOV, n = 25) and vegan (VEG, n = 23) recreational runners. Oxidative stress was measured as malondialdehyde (MDA), NO as nitrite and nitrate, and various amino acids, including homoarginine and guanidinoacetate, the precursor of creatine. All analytes were measured by validated stable-isotope dilution gas chromatographic-mass spectrometric methods. Pre-exercise, VEG had the highest MDA and nitrate concentratio

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14

Schlag, Steffen, Christiane Nerz, Timo A. Birkenstock, Florian Altenberend, and Friedrich Götz. "Inhibition of Staphylococcal Biofilm Formation by Nitrite." Journal of Bacteriology 189, no. 21 (2007): 7911–19. http://dx.doi.org/10.1128/jb.00598-07.

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ABSTRACT Several environmental stresses have been demonstrated to increase polysaccharide intercellular adhesin (PIA) synthesis and biofilm formation by the human pathogens Staphylococcus aureus and Staphylococcus epidermidis. In this study we characterized an adaptive response of S. aureus SA113 to nitrite-induced stress and show that it involves concomitant impairment of PIA synthesis and biofilm formation. Transcriptional analysis provided evidence that nitrite, either as the endogenous product of respiratory nitrate reduction or after external addition, causes repression of the icaADBC gen

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15

Sindler, Amy L., Allison E. DeVan, Bradley S. Fleenor, and Douglas R. Seals. "Inorganic nitrite supplementation for healthy arterial aging." Journal of Applied Physiology 116, no. 5 (2014): 463–77. http://dx.doi.org/10.1152/japplphysiol.01100.2013.

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Aging is the major risk factor for cardiovascular diseases (CVD). This is attributable primarily to adverse changes in arteries, notably, increases in large elastic artery stiffness and endothelial dysfunction mediated by inadequate concentrations of the vascular-protective molecule, nitric oxide (NO), and higher levels of oxidative stress and inflammation. Inorganic nitrite is a promising precursor molecule for augmenting circulating and tissue NO bioavailability because it requires only a one-step reduction to NO. Nitrite also acts as an independent signaling molecule, exerting many of the e

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16

Reijrink, Melanie, Stefanie A. De Boer, Anniek M. Van Roon, et al. "Plasma Nitrate Levels Are Related to Metabolic Syndrome and Are Not Altered by Treatment with DPP-4 Inhibitor Linagliptin: A Randomised, Placebo-Controlled Trial in Patients with Early Type 2 Diabetes Mellitus." Antioxidants 10, no. 10 (2021): 1548. http://dx.doi.org/10.3390/antiox10101548.

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The depletion of nitrate and nitrite, stable nitric oxide (NO) end-products, promotes adipose tissue dysfunction and insulin resistance (IR). Dipeptidyl peptidase-4 (DPP-4) inhibitors have the potentially beneficial side effect of increasing NO availability. In this study, nitrate and nitrite levels and the effects of DPP-4 inhibitor linagliptin were investigated in relation to metabolic syndrome (MetS) markers. Treatment-naive patients with early type 2 diabetes mellitus (T2DM) (n = 40, median age 63 IQR (55–67) years, 63% male, mean HbA1c 45 ± 4.4 mmol/mol) were randomized (1:1) to linaglipt

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17

Ikonomidis, Ignatios, George Pavlidis, Maria Tsoumani, et al. "Endothelial Dysfunction Is Associated with Decreased Nitric Oxide Bioavailability in Dysglycaemic Subjects and First-Degree Relatives of Type 2 Diabetic Patients." Journal of Clinical Medicine 11, no. 12 (2022): 3299. http://dx.doi.org/10.3390/jcm11123299.

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Oxidative stress plays an important role in the pathogenesis of diabetes. We investigated oxidative stress and nitrite/nitrate concentrations at baseline and during postprandial hyperglycaemia in 40 first-degree relatives (FDRs) of diabetic patients with normal oral glucose tolerance test (OGTT) results, 40 subjects with abnormal OGTT results (dysglycaemic) and 20 subjects with normal OGTT results (normoglycaemic). Malondialdehyde (MDA), protein carbonyls (PCs), nitrite/nitrate plasma levels, the perfused boundary region (PBR—Glycocheck) of the sublingual microvessels, a marker of glycocalyx i

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18

Gubina-Vakulyck, G. I., S. A. Denysenko, T. V. Gorbach, Ye M. Zorenko, and V. S. Goydina. "Morphofunctional state of the medulla and the fascicular zone of the adrenal cortex in modeling Alzheimer's disease by excessive administration of sodium nitrite." Morphologia 15, no. 3 (2021): 76–83. http://dx.doi.org/10.26641/1997-9665.2021.3.76-83.

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Background. Nitrates and nitrites are found in soil, water, human food, dyes, and medicines. In the literature, both positive and negative effects from the ingestion of nitrates and nitrites into the body are considered. A nitrite model of Alzheimer's type dementia of vascular origin was used in the work. Objective. The aim of the study was to study the morphofunctional state of the adrenal glands of experimental animals with prolonged administration of sodium nitrite. The study was carried out on male rats of the WAG population, which were divided into 3 groups: gr. N-14 - received injections

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19

Christ, Ricardo, Aleksandro Schafer Da Silva, Mateus Eloir Gabriel, et al. "Cholinesterase Activities and Oxidative Stress in Cattle Experimentally Exposed to Nitrate/Nitrite in Cultivated Pasture with Different Fertilization Schemes." Acta Scientiae Veterinariae 46, no. 1 (2018): 9. http://dx.doi.org/10.22456/1679-9216.86680.

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Background: Nitrate and nitrite poisoning is associated with pasture intake that has high nitrate levels and leads to acute methemoglobinemia. Pasture may accumulate nitrate under certain conditions, such as excessively fertilized soil or environmental conditions that enhance the N absorption (rain preceded by a period of drought). After ingestion of plants, this substrate reaches the rumen and, in physiological conditions, is reduced to nitrite and afterward to ammonia. The aim of this study was to evaluate changes in cholinesterase activities and oxidative stress caused by subclinical poison

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20

Maslakova, A. O., and M. Ya Liuta. "Photobiomodulation therapy protects red blood cells against nitrative stress during streptozotocin-induced diabetes." Studia Biologica 16, no. 3 (2022): 3–18. http://dx.doi.org/10.30970/sbi.1603.685.

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Background. According to the International Diabetes Federation Diabetes Atlas, 10th edition, diabetes is responsible for 6.7 million deaths in 2021. Diabetes mellitus is a group of metabolic disorders characterized by hyperglycemia secondary to either resistance to insulin, insufficient insulin secretion, or both. Oxidative and nitrative stress is a vital part of the complex mechanism by which diabetes and its complications develop. It is known that Photobiomodulation therapy accelerates diabetic wound healing, treats relegated inflammation, and increases oxygen availability for cells. Althoug

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21

Liu, Xiaochen, Daixia Wang, Yan Shang, et al. "Survival, Energy Status, and Cellular Stress Responses of the Juvenile Swimming Crab Portunus trituberculatus under Acute Nitrite Stress." Fishes 8, no. 4 (2023): 215. http://dx.doi.org/10.3390/fishes8040215.

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Nitrite is a common pollutant encountered in aquaculture systems. During intensive hatchery, accumulation of nitrite can cause massive mortality of juvenile crustaceans. However, the nitrite toxicity and cellular stress responses in juvenile crustaceans is not clearly understood. Here, we investigate the survival, energy metabolism, and cellular stress responses in juvenile P. trituberculatus, an important aquaculture species in China, under acute nitrite stress. The results revealed nitrite resulted in a significant decrease in survival rate of juvenile swimming crab. After nitrite exposure,

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22

Galiniak, Sabina, Marek Biesiadecki, Mateusz Mołoń, Patrycja Olech, and Krzysztof Balawender. "Serum Oxidative and Nitrosative Stress Markers in Clear Cell Renal Cell Carcinoma." Cancers 15, no. 15 (2023): 3995. http://dx.doi.org/10.3390/cancers15153995.

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Oxidative stress is believed to be a factor in the development and progression of renal cell carcinoma (RCC). The identification of the oxidative and nitrosative modification of proteins and the definition of their roles in clear cell RCC (ccRCC) may be helpful in the elaboration of targeted therapeutic approaches to mitigate protein damage. This study aimed to investigate the status of oxidative/nitrosative stress and to explore its role in the development and progression. The studied group consisted of 48 newly diagnosed ccRCC and 30 healthy controls. Serum levels of oxidative stress markers

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May, James M., Zhi-Chao Qu, Li Xia, and Charles E. Cobb. "Nitrite uptake and metabolism and oxidant stress in human erythrocytes." American Journal of Physiology-Cell Physiology 279, no. 6 (2000): C1946—C1954. http://dx.doi.org/10.1152/ajpcell.2000.279.6.c1946.

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Nitric oxide, when released into the bloodstream, is quickly scavenged by Hb in erythrocytes or oxidized to nitrite. Nitrite can also enter erythrocytes and oxidize Hb. The goals of this work were to determine the mechanism of erythrocyte nitrite uptake and whether this uptake causes oxidant stress in these cells. Erythrocytes took up 0.8 mM nitrite with a half-time of 11 min. Nitrite uptake was sensitive to temperature and to the pH and ionic composition of the medium but was not inhibited by the specific anion-exchange inhibitor DIDS. About 25% of nitrite uptake occurred on the sodium-depend

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Gratziou, C., N. Rovina, M. Makris, D. C. M. Simoes, A. Papapetropoulos, and C. Roussos. "Breath Markers of Oxidative Stress and Airway Inflammation in Seasonal Allergic Rhinitis." International Journal of Immunopathology and Pharmacology 21, no. 4 (2008): 949–57. http://dx.doi.org/10.1177/039463200802100419.

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Oxidative stress (OS) is well documented in asthma, but so far little data has been reported in non-asthmatic patients with Seasonal Allergic Rhinitis (SAR). The aim of this study is to investigate the degree of OS and airway inflammation in patients with SAR, with and without concomitant Asthma (SAR +A), using breath markers in exhaled air and in Exhaled Breath Condensate (EBC). In addition, the effects of natural allergen exposure and intranasal steroid treatment on these markers were evaluated. Exhaled NO (eNO) and CO, combined with measurements of 8-Isoprostane (Iso-8), Leukotriene B4 (LTB

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Xu, Zhenkun, Hongzhi Zhang, Meijie Guo, Dan Fang, Jun Mei, and Jing Xie. "Analysis of Acute Nitrite Exposure on Physiological Stress Response, Oxidative Stress, Gill Tissue Morphology and Immune Response of Large Yellow Croaker (Larimichthys crocea)." Animals 12, no. 14 (2022): 1791. http://dx.doi.org/10.3390/ani12141791.

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Nitrite is a common pollutant in aquaculture water, and nitrite toxicity that negatively affects aquatic species is common in aquaculture systems when the water quality is low. Therefore, the present research aimed to evaluate the effect of acute nitrite exposure on the hematological parameters, antioxidant enzymes, immune response, and gill morphology of large yellow croaker (Larimichthys crocea). The fish were randomly separated and exposed to four (i.e., 0, 29.36, 58.73, and 88.09 mg/L) nitrite concentrations for 48 h. The fish blood and gills were collected at 0, 12, 24, 36, and 48 h of ni

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Hirabayashi, Naoki, Hiroshi Tanimura, and Hiroki Yamaue. "Nitrite/Nitrate Oxide and Cytokines Changes in Patients with Surgical Stress." Digestive Diseases and Sciences 50, no. 5 (2005): 893–97. http://dx.doi.org/10.1007/s10620-005-2661-2.

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27

Muñoz-Sánchez, Germán, Lucila A. Godínez-Méndez, Mary Fafutis-Morris, and Vidal Delgado-Rizo. "Effect of Antioxidant Supplementation on NET Formation Induced by LPS In Vitro; the Roles of Vitamins E and C, Glutathione, and N-acetyl Cysteine." International Journal of Molecular Sciences 24, no. 17 (2023): 13162. http://dx.doi.org/10.3390/ijms241713162.

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Neutrophil extracellular traps (NETs) require reactive oxygen species (ROS) to eliminate pathogens by inducing oxidative stress. However, this process can also cause tissue damage to the host. Neutrophils contain high concentrations of vitamin C (1.5 mM) compared to the bloodstream (0.1 mM), and this antioxidant can interact with vitamin E and glutathione (GSH) inside the cell to maintain the redox balance. Previous studies have investigated the effect of vitamins E or C and N-acetyl cysteine (NAC) on NET formation, but the interactions of these molecules in neutrophils remain unknown. In this

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Costa-Broseta, Álvaro, MariCruz Castillo, and José León. "Nitrite Reductase 1 Is a Target of Nitric Oxide-Mediated Post-Translational Modifications and Controls Nitrogen Flux and Growth in Arabidopsis." International Journal of Molecular Sciences 21, no. 19 (2020): 7270. http://dx.doi.org/10.3390/ijms21197270.

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Plant growth is the result of the coordinated photosynthesis-mediated assimilation of oxidized forms of C, N and S. Nitrate is the predominant N source in soils and its reductive assimilation requires the successive activities of soluble cytosolic NADH-nitrate reductases (NR) and plastid stroma ferredoxin-nitrite reductases (NiR) allowing the conversion of nitrate to nitrite and then to ammonium. However, nitrite, instead of being reduced to ammonium in plastids, can be reduced to nitric oxide (NO) in mitochondria, through a process that is relevant under hypoxic conditions, or in the cytoplas

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Napolitano, Gaetana, Gianluca Fasciolo, Claudio Agnisola, and Paola Venditti. "Urea Excretion and Arginase Activity as New Biomarkers for Nitrite Stress in Freshwater Aquatic Animals." Water 13, no. 24 (2021): 3521. http://dx.doi.org/10.3390/w13243521.

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Background: In recent years, the concern has been growing on increasing aquatic nitrite levels due to anthropogenic activities. Crustaceans and fish easily uptake nitrite via the chloride uptake system of gills. High nitrite body levels may interfere with nitric oxide (NO) production by nitric oxide synthase (NOS). The arginase, which catalyzes arginine conversion to ornithine and urea, is central to NO homeostasis. In vivo, changes in the arginase activity alter urea body levels and urea excretion and modulate NOS by altering arginine availability for NO synthesis. Excess arginase activity ma

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Wu, Fan, Xiaobo Sun, Xingfeng Hu, et al. "Response of Nitrogen Metabolism in Masson Pine Needles to Elevated CO2." Forests 11, no. 4 (2020): 390. http://dx.doi.org/10.3390/f11040390.

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To explore the response of nitrogen metabolism in Masson pine (Pinus massoniana) to high CO2 concentrations, needles from one-year-old seedlings were used as materials to detect key enzyme activities, gene expression and different forms of nitrogen metabolites after CO2 stress for different durations (0 h, 6 h, 12 h, 24 h). The results show that elevated CO2 affected the efficiency of nitrogen metabolism in Masson pine needles, inhibiting the expression of key genes involved in nitrogen metabolism, including glutamate synthase (GOGAT), nitrite reductase (NiR), glutamine synthase (GS), nitrate

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Gamal, Maha, Zainab Abdel Wahab, Mohamed Eshra, Laila Rashed, and Nivin Sharawy. "Comparative Neuroprotective Effects of Dexamethasone and Minocycline during Hepatic Encephalopathy." Neurology Research International 2014 (2014): 1–8. http://dx.doi.org/10.1155/2014/254683.

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Objective.Encephalopathy and brain edema are serious complications of acute liver injury and may lead to rapid death of patients. The present study was designed to investigate the role of the inflammatory mediators and oxidative stress in the cytotoxic brain oedema and the neuroprotective effects of both minocycline and dexamethasone.Methods.48 male albino rats were divided into 4 groups: control group, acute liver injury (ALI) group, minocycline pretreated ALI group, and dexamethasone pretreated ALI group. 24 hours after acute liver injury serum ammonia, liver enzymes, brain levels of heme ox

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Hu, Zhenyi, Chenglong Qi, Chenzhi Lin, and Rong Tang. "Nitrite Stress Induces Oxidative Stress and Leads to Muscle Quality Decreased in Wuchang Bream (Megalobrama amblycephala Yih) Juveniles." Water 14, no. 2 (2022): 160. http://dx.doi.org/10.3390/w14020160.

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To determine the effects of nitrite exposure on muscle quality and physiological functions in Wuchang bream (Megalobrama amblycephala), we exposed M. amblycephala juveniles to acute nitrite (0, 1, 5, 10, 20 mg/L), and the muscle and blood samples were measured at 12, 24, 48, and 96 h. The results showed that when exposed to nitrite for 12 h, the concentrations of blood glucose, cortisol, aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the 20 mg/L experimental group had the maximum value. The activity of lactate dehydrogenase (LDH) increased significantly in a dose-depen

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Kanzelmeyer, Nele Kirsten, Lars Pape, Kristine Chobanyan-Jürgens, et al. "L-Arginine/NO Pathway Is Altered in Children with Haemolytic-Uraemic Syndrome (HUS)." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–9. http://dx.doi.org/10.1155/2014/203512.

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The haemolytic uraemic syndrome (HUS) is the most frequent cause of acute renal failure in childhood. We investigated L-arginine/NO pathway in 12 children with typical HUS and 12 age-matched healthy control subjects. Nitrite and nitrate, the major NO metabolites in plasma and urine, asymmetric dimethylarginine (ADMA) in plasma and urine, and dimethylamine (DMA) in urine were determined by GC-MS and GC-MS/MS techniques. Urinary measurements were corrected for creatinine excretion. Plasma nitrate was significantly higher in HUS patients compared to healthy controlsP=0.021, whereas urine nitrate

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Vine, Claire E., and Jeffrey A. Cole. "Nitrosative stress in Escherichia coli: reduction of nitric oxide." Biochemical Society Transactions 39, no. 1 (2011): 213–15. http://dx.doi.org/10.1042/bst0390213.

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The ability of enteric bacteria to protect themselves against reactive nitrogen species generated by their own metabolism, or as part of the innate immune response, is critical to their survival. One important defence mechanism is their ability to reduce NO (nitric oxide) to harmless products. The highest rates of NO reduction by Escherichia coli K-12 were detected after anaerobic growth in the presence of nitrate. Four proteins have been implicated as catalysts of NO reduction: the cytoplasmic sirohaem-containing nitrite reductase, NirB; the periplasmic cytochrome c nitrite reductase, NrfA; t

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Polhemus, David J., Jessica M. Bradley, Kazi N. Islam, et al. "Therapeutic potential of sustained-release sodium nitrite for critical limb ischemia in the setting of metabolic syndrome." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 1 (2015): H82—H92. http://dx.doi.org/10.1152/ajpheart.00115.2015.

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Nitrite is a storage reservoir of nitric oxide that is readily reduced to nitric oxide under pathological conditions. Previous studies have demonstrated that nitrite levels are significantly reduced in cardiovascular disease states, including peripheral vascular disease. We investigated the cytoprotective and proangiogenic actions of a novel, sustained-release formulation of nitrite (SR-nitrite) in a clinically relevant in vivo swine model of critical limb ischemia (CLI) involving central obesity and metabolic syndrome. CLI was induced in obese Ossabaw swine ( n = 18) by unilateral external il

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Raat, Nicolaas J., Audrey C. Noguchi, Virginia Liu, et al. "P52. Dietary nitrate and nitrite modulate the cellular response to ischemic stress." Nitric Oxide 19 (2008): 55. http://dx.doi.org/10.1016/j.niox.2008.06.149.

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Gào, Xīn, Yang Xuan, Axel Benner, Ankita Anusruti, Hermann Brenner, and Ben Schöttker. "Nitric Oxide Metabolites and Lung Cancer Incidence: A Matched Case-Control Study Nested in the ESTHER Cohort." Oxidative Medicine and Cellular Longevity 2019 (September 2, 2019): 1–9. http://dx.doi.org/10.1155/2019/6470950.

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Studies suggest that nitric oxide (NO) may have a possible role in lung carcinogenesis. This study is aimed to evaluate the association of the NO metabolites, namely, nitrite and nitrate, with lung cancer incidence. We conducted a matched case-control study (n=245 incident lung cancer cases and n=735 controls) based on the German ESTHER cohort (n=9,940). Controls were matched to cases on age, sex, smoking status (never/former/current smoking), and pack-years of smoking. The sum of nitrite and nitrate was measured in urine samples using a colorimetric assay and was standardized for renal functi

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Famitafreshi, Hamidreza, and Morteza Karimian. "Social State Influences Memory in Novel Object Recognition Test Through Oxidative Stress Balance in Male Rats." Open Pharmacology Journal 8, no. 1 (2018): 1–9. http://dx.doi.org/10.2174/1874143601808010001.

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Objective:Social isolation is associated with adverse effects on brain functions. According to previous studies, the reduction of oxidative stress improves cognitive functions. Memory performance is dependent on hippocampus and prefrontal function. The aim of this study is to show that impairment of memory in object recognition test in isolation state is accompanied by deregulation of oxidative stress balance in related areas.Methods and Materials:In this study, 14 male Sprague-Dawley rats were randomly divided into two groups as follows: social and isolation. Socialization and isolation plus

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Pimková, Kristýna, Leona Chrastinová, Jiří Suttnar, et al. "Plasma Levels of Aminothiols, Nitrite, Nitrate, and Malondialdehyde in Myelodysplastic Syndromes in the Context of Clinical Outcomes and as a Consequence of Iron Overload." Oxidative Medicine and Cellular Longevity 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/416028.

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The role of oxidative stress in the initiation and progression of myelodysplastic syndromes (MDS) as a consequence of iron overload remains unclear. In this study we have simultaneously quantified plasma low-molecular-weight aminothiols, malondialdehyde, nitrite, and nitrate and have studied their correlation with serum iron/ferritin levels, patient treatment (chelation therapy), and clinical outcomes. We found significantly elevated plasma levels of total, oxidized, and reduced forms of cysteineP<0.001, homocysteineP<0.001, and cysteinylglycineP<0.006and significantly depressed level

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Honoré, Jean-Claude, Amna Kooli, Xin Hou, et al. "Sustained hypercapnia induces cerebral microvascular degeneration in the immature brain through induction of nitrative stress." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 298, no. 6 (2010): R1522—R1530. http://dx.doi.org/10.1152/ajpregu.00807.2009.

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Hypercapnia is regularly observed in chronic lung disease, such as bronchopulmonary dysplasia in preterm infants. Hypercapnia results in increased nitric oxide synthase activity and in vitro formation of nitrates. Neural vasculature of the immature subject is particularly sensitive to nitrative stress. We investigated whether exposure to clinically relevant sustained high CO2 causes microvascular degeneration in the newborn brain by inducing nitrative stress, and whether this microvascular degeneration has an impact on brain growth. Newborn rat pups were exposed to 10% CO2 as inspired gas (PaC

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Lee, Jae Won, Ee Taek Hwang, and Jin Soo Han. "Protective Effects of Topical Application of Nitrite on Testicular Ischemia-Reperfusion Injury in Rats." Oxidative Medicine and Cellular Longevity 2021 (June 26, 2021): 1–10. http://dx.doi.org/10.1155/2021/5514537.

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Testicular torsion is a urologic emergency induced by torsion of the spermatic cord, interrupting blood circulation to the testis. Therapeutic options for testicular torsion, except surgical restoration of testis, are rarely applied in clinical practice. This study, therefore, investigated whether topical application of nitrite (NO2-) is beneficial in tissue damage due to testicular ischemia-reperfusion (I/R) injury in rats. Pubertal Sprague-Dawley rats were assigned to seven groups: group A, sham-operated control group; group B, I/R with no treatment; groups C, D, and E, I/R followed by treat

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Trautwein, Kathleen, Simon Kühner, Lars Wöhlbrand, et al. "Solvent Stress Response of the Denitrifying Bacterium “Aromatoleum aromaticum” Strain EbN1." Applied and Environmental Microbiology 74, no. 8 (2008): 2267–74. http://dx.doi.org/10.1128/aem.02381-07.

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ABSTRACT The denitrifying betaproteobacterium “Aromatoleum aromaticum” strain EbN1 degrades several aromatic compounds, including ethylbenzene, toluene, p-cresol, and phenol, under anoxic conditions. The hydrophobicity of these aromatic solvents determines their toxic properties. Here, we investigated the response of strain EbN1 to aromatic substrates at semi-inhibitory (about 50% growth inhibition) concentrations under two different conditions: first, during anaerobic growth with ethylbenzene (0.32 mM) or toluene (0.74 mM); and second, when anaerobic succinate-utilizing cultures were shocked

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Bradley, Jessica M., Kazi N. Islam, David J. Polhemus, et al. "Sustained release nitrite therapy results in myocardial protection in a porcine model of metabolic syndrome with peripheral vascular disease." American Journal of Physiology-Heart and Circulatory Physiology 309, no. 2 (2015): H305—H317. http://dx.doi.org/10.1152/ajpheart.00163.2015.

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Metabolic syndrome (MetS) reduces endothelial nitric oxide (NO) bioavailability and exacerbates vascular dysfunction in patients with preexisting vascular diseases. Nitrite, a storage form of NO, can mediate vascular function during pathological conditions when endogenous NO is reduced. The aims of the present study were to characterize the effects of severe MetS and obesity on dyslipidemia, myocardial oxidative stress, and endothelial NO synthase (eNOS) regulation in the obese Ossabaw swine (OS) model and to examine the effects of a novel, sustained-release formulation of sodium nitrite (SR-n

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Fernandes, Monique Carolina Nunes, Flávia Barbosa Silva Botelho, Kamila Rezende Dázio de Souza, Gabrielle Carvalho Pereira, Camila Soares Cardoso da Silva, and Douglas Goulart Castro. "ATIVIDADE DA ENZIMA NITRATO REDUTASE EM ARROZ DE TERRAS ALTAS SOB CONDIÇÕES DE ESTRESSE HÍDRICOS." Nativa 8, no. 4 (2020): 484–89. http://dx.doi.org/10.31413/nativa.v8i4.9707.

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A assimilação de nitrogênio é um processo vital que controla o crescimento e desenvolvimento da planta, garantindo bons níveis de produtividade de grãos. A enzima nitrato redutase (NR) catalisa o primeiro passo enzimático da assimilação de nitrogênio pelas plantas superiores por meio da redução do nitrato (NO3-) a nitrito (NO2-). Assim, objetivou-se estudar a atividade da enzima redutase do nitrato em genótipos de arroz de terras altas e correlacioná-la com os demais caracteres agronômicos. O experimento foi conduzido em dois ambientes distintos, com e sem irrigação suplementar. As análises de

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Hsu, Dur-Zong, Ya-Hui Li, Pei-Yi Chu, Srinivasan Periasamy, and Ming-Yie Liu. "Sesame Oil Prevents Acute Kidney Injury Induced by the Synergistic Action of Aminoglycoside and Iodinated Contrast in Rats." Antimicrobial Agents and Chemotherapy 55, no. 6 (2011): 2532–36. http://dx.doi.org/10.1128/aac.01597-10.

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ABSTRACTThe aim of the study was to investigate the effect of sesame oil on acute kidney injury induced by the synergistic action of aminoglycoside and iodinated contrast in rats. Acute kidney injury was induced by a 5-day course of daily gentamicin injections (100 mg/kg of body weight, subcutaneously) and then iodinated contrast (4 ml/kg, intravenously) in male specific-pathogen-free Sprague-Dawley rats. Sesame oil (0.5 ml/kg, orally) was given 1 h before iodinated contrast. Renal function and oxidative stress were assessed 6 h after iodinated contrast injection. Renal function was evaluated

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Krishna Rao, R., and A. Gnanam. "Inhibition of nitrate and nitrite reductase activities by salinity stress in Sorghum vulgare." Phytochemistry 29, no. 4 (1990): 1047–49. http://dx.doi.org/10.1016/0031-9422(90)85400-a.

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Durzand, D. "Stress-induced nitric oxide and adaptive plasticity in conifers." Journal of Forest Science 48, No. 7 (2019): 281–91. http://dx.doi.org/10.17221/11888-jfs.

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The excitable properties of conifer protoplasm consist of nitric oxide (NO) bursts that prime and prepare chemical messengers for the transmission of stressful environmental signals. NO in somatic and reproductive cells is produced in response to mechanical forces, gravity, wounding, changes in nutrition, hypoxia, drought, salinity, temperature shock, pollutants, and <br /> pathogen attack. NO arises primarily from nitrite via nitrite:nitric oxide reductase and nitrate reductase. It also arises from arginine N and oxygen via putative nitric oxide synthase activity. NO rapidly reacts with

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Reddy, C. Prabhakar, Uday Kumar Chiranjeevi, Chandrasekhar N., Kiran Kishore K., and Kishan P. V. "Correlation between endothelial dysfunction, inflammatory status, oxidative stress and total (nitrite/ nitrate) in subjects with diabetes mellitus type 2." International Journal of Basic & Clinical Pharmacology 6, no. 10 (2017): 2317. http://dx.doi.org/10.18203/2319-2003.ijbcp20174157.

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Background: Diabetes Mellitus is a systemic metabolic disorder associated with Endothelial dysfunction and increased systemic inflammatory state with oxidative stress leading to increased Cardiovascular risk. This study planned to correlate the level of Endothelial dysfunction with oxidative stress and inflammatory status.Methods: Study was conducted in 60 Diabetes Mellitus subjects of both genders with duration of more than two years. Endothelial dysfunction assessed as Augmentation Pressure and Augmentation Index generated from Radial artery waveforms by tonometer using Spygmocor PWA system.

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Kim, Jun-Hwan, Yue Jai Kang, and Kyung Mi Lee. "Effects of Nitrite Exposure on the Hematological Properties, Antioxidant and Stress Responses of Juvenile Hybrid Groupers, Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀." Antioxidants 11, no. 3 (2022): 545. http://dx.doi.org/10.3390/antiox11030545.

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Nitrite concentrations can reach high levels in indoor aquaculture systems, thus it is vital to determine the nitrite tolerance of aquaculture fish species. Here, juvenile hybrid groupers (Epinephelus lanceolatus ♂ × Epinephelus fuscoguttatus ♀, Family: Serranidae) were exposed to waterborne nitrite at 0, 10, 20, 40, and 80 mg NO2−/L for 2 weeks. Nitrite exposure caused significant reductions in hematocrit and hemoglobin levels, significant increases in plasma calcium and plasma ALP levels, but had no significant effects on magnesium and total protein levels. Of the antioxidant responses inves

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Godbole, Anjali S., Xiao Lu, Xiaomei Guo, and Ghassan S. Kassab. "NADPH oxidase has a directional response to shear stress." American Journal of Physiology-Heart and Circulatory Physiology 296, no. 1 (2009): H152—H158. http://dx.doi.org/10.1152/ajpheart.01251.2007.

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Vessel regions with predilection to atherosclerosis have negative wall shear stress due to flow reversal. The flow reversal causes the production of superoxides (O2−), which scavenge nitric oxide (NO), leading to a decrease in NO bioavailability and endothelial dysfunction. Here, we implicate NADPH oxidase as the primary source of O2− during full flow reversal. Nitrite production and the degree of vasodilation were measured in 46 porcine common femoral arteries in an ex vivo system. Nitrite production and vasodilation were determined before and after the inhibition of NADPH oxidase, xanthine o

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