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Journal articles on the topic 'Nitro derivative'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Miller, Eric M., Cody J. Brazel, Krystina A. Brillos-Monia, et al. "Reduction Potential Predictions for Some 3-Aryl-Quinoxaline-2-Carbonitrile 1,4-Di-N-Oxide Derivatives with Known Anti-Tumor Properties." Computation 7, no. 1 (2019): 6. http://dx.doi.org/10.3390/computation7010006.

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The ability for DFT: B3LYP calculations using the 6-31g and lanl2dz basis sets to predict the electrochemical properties of twenty (20) 3-aryl-quinoxaline-2-carbonitrile 1,4-di-N-oxide derivatives with varying degrees of cytotoxic activity in dimethylformamide (DMF) was investigated. There was a strong correlation for the first reduction and moderate-to-low correlation of the second reduction of the diazine ring between the computational and the experimental data, with the exception of the derivative containing the nitro functionality. The four (4) nitro group derivatives are clear outliers in

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2

Burgess, VA, та CJ Easton. "Reaction of N-Benzoyl-2-bromoglycine Methyl Ester With Deprotonated Nitroalkanes: Synthesis of β-Nitro and α,β-Dehydro Amino Acid Derivatives". Australian Journal of Chemistry 41, № 7 (1988): 1063. http://dx.doi.org/10.1071/ch9881063.

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N-Benzoyl-2-bromoglycine methyl ester (1) reacted with the alkyl nitronates (2a-e) to give the corresponding β-nitro amino acid derivatives (4a-e). Elimination reactions of (4a-d) afforded the α,β-dehydro amino acid derivatives (5a-d). Treatment of the β- nitrovaline derivative (4b) with tributyltin hydride gave the valine derivative (8). Reduction of the β- nitroalanine derivative (4a) gave the β- aminoalanine derivative (9), characterized by hydrolysis to 2,3- diaminopropionic acid hydrochloride.

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3

Kurfürst, Antonín, Pavel Lhoták, Petr Nádeník, Františka Raclová-Pavlíková, and Josef Kuthan. "2-(Biphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (PBD): Electrophilic 4’-substitution and following transformations." Collection of Czechoslovak Chemical Communications 56, no. 7 (1991): 1495–504. http://dx.doi.org/10.1135/cccc19911495.

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PBD was converted into 4’-substituted derivatives I-XII using usual electrophilic reagents. The decomposition of PBD, 4’-acetyl derivative I and 4’-nitro derivative VI with hydroiodic acid gave 4’-substituted 4-biphenylcarboxylic acids XIIIa-XIIIc and benzoic acid, respectively. The regioselectivity of the reaction was also proved by means of high resolution NMR spectroscopy.

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4

Hidayah, Nurul, Bambang Purwono, and Harno Dwi Pranowo. "One Step Synthesis of Symmetrical Amino Azine Derivatives Using Hydrazine Hydrate as a Reagent." Key Engineering Materials 840 (April 2020): 257–64. http://dx.doi.org/10.4028/www.scientific.net/kem.840.257.

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Symmetrical Amino Azine derivative compound of 6,6'-((1E,1'E)-hydrazine-1,2-diylidenebis (methanyl-ylidene)) bis (3,4-dimethoxyaniline) TM has been synthesized through an unusual reaction route employed benzylidine derivative with some electron withdrawing groups as intermediate compounds. The targeted TM compound was prepared by one pot reaction of the intermediate 2-(4,5-dimethoxy-2-nitrobenzylidene) malononitrile 3 or (E)-1,2-dimethoxy-4-nitro-5-(2-nitrovinyl)-benzene 4 or nitrohydrazone 5 with excess 80% hydrazine hydrate and 10% Pd/C catalyst. However, direct synthesis to produce TM using

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5

Dynarowicz-Łątka, Patrycja, and Piotr Milart. "Synthesis and Langmuir Monolayer Characterisation of Some Nitro Derivatives of Polyphenyl Carboxylic Acids." Journal of Chemical Research 2009, no. 4 (2009): 225–28. http://dx.doi.org/10.3184/030823409x417289.

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Derivatives of 5′-phenyl-1,1′:3′,1″-terphenyl-4-carboxylic acid (PTCA), each with 4′-nitro-substituents (2 and 5) have been synthesised and characterised as Langmuir monolayers at the air/water interface. Surface pressure and electric surface potential measurements of the monolayers under a variety of experimental conditions have been made. The presence of the nitro-substituent (in 2 cf 2′) was found to change the sign of the measured surface potential, indicating that the nitro-derivative is oriented with the -NO2 group towards the air side, while the carboxylic group is anchored into the wat

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6

Arnold, Dennis P., Raymond C. Bott, Helen Eldridge, Fiona M. Elms, Graham Smith, and Mike Zojaji. "Functionalization of 5,15-Diphenylporphyrin: Preparation and X-Ray Crystal Structures of meso Nitro, Bromo, and Trimethylsilylethynyl Derivatives." Australian Journal of Chemistry 50, no. 5 (1997): 495. http://dx.doi.org/10.1071/c96193.

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Substitutions on 5,15-diphenylporphyrin led to the isolation of mono- and di-bromo and mono- and di-nitro derivatives, which were converted into their respective nickel(II) complexes. Reaction of the bromoporphyrins with iodine/silver nitrite resulted in nitrodebromination as well as conventional nitration. The nickel(II) complex of 5-nitro-10,20-diphenylporphyrin was reduced to the 5-amino derivative. The nickel(II) complexes of the bromoporphyrins were converted into the respective mono- and bis-(trimethylsilylethynyl) species. The crystal structures of 5-nitro-10,20-diphenylporphyrin, 5-bro

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7

Corinti, Davide, Barbara Gregori, Leonardo Guidoni, et al. "Complexation of halide ions to tyrosine: role of non-covalent interactions evidenced by IRMPD spectroscopy." Physical Chemistry Chemical Physics 20, no. 6 (2018): 4429–41. http://dx.doi.org/10.1039/c7cp06657k.

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8

Möhrle, H., and J. Mehrens. "Reaktivität nitrophenylsubstituierter cyclischer Amine bei Dehydrierungen / The Reactivity of Nitrophenyl Substituted Cyclic Amines with Dehydrogenations." Zeitschrift für Naturforschung B 53, no. 1 (1998): 37–48. http://dx.doi.org/10.1515/znb-1998-0109.

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Piperidine and perhydroazepine bearing a 1 -(4-nitrophenyl) substituent were inert to mercury-edta, while the a-pipecoline derivative gave an aminoketone with cleavage of the heterocycle. However the corresponding (2-nitrophenyl) compounds reacted to give respectively a piperidin-2-one, an aminopentanal and an aminohexanone.By an additional substituent in 2′-position the p-nitro compounds underwent dehydrogenation too. With a methyl group resulted a pattern analogous to o-nitro products. A neighbouring hydroxymethyl function enhanced the reaction with formation of benzoxazines and if possible

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9

Al-Masoudi, Najim A., Yaseen A. Al-Soud, Erik De Clercq, and Christophe Pannecouque. "Nitroimidazoles Part 6. Synthesis, Structure and in Vitro anti-HIV Activity of New 5-substituted Piperazinyl-4-nitroimidazole Derivatives." Antiviral Chemistry and Chemotherapy 18, no. 4 (2007): 191–200. http://dx.doi.org/10.1177/095632020701800403.

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2-Amino-1-[4-(1-benzyl-2-ethyl-4-nitro-1 H-imidazol-5-yl)piperazin-1-yl]ethanone [6] was prepared from 1-(1-benzyl-2-ethyl-4-nitro-1 H-imidazol-5-yl) piperazine [3]. A series of new 2-oxoethyl-arylamide [9,10] and 2-oxoethyl-arylsulphonamide [11–14] derivatives were synthesized from [6] with the aim of developing new non-nucleoside reverse transcriptase inhibitors. Alternatively, the amine [17] was synthesized from [3] via the phthalimide derivative [16]. The arylsulphonamide derivatives [18–23] and the arylamide analogues [24–26] were synthesized from [17]. The compounds were evaluated for th

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10

Baer, Hans H., Isamu Arai, Bruno Radatus, June Rodwell, and Nguyen Chinh. "A chiral approach to 2-deoxystreptamine." Canadian Journal of Chemistry 65, no. 7 (1987): 1443–51. http://dx.doi.org/10.1139/v87-246.

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A new synthesis of 2-deoxystreptamine (21), a component of numerous antibiotics, was developed. Starting from D-mannose, it proceeds through chiral intermediates and is designed to furnish starting points for the preparation of stereospecifically modified derivatives of the meso compound 21. 1,2-Dideoxy-1-nitro-D-manno-heptitol (2), obtainable from mannose by the nitromethane method, was protected as the 4,5:6,7-di-O-isopropylidene derivative 4, which was mesylated or triflated in position 3. From the sulfonic esters (5 and 6) two different routes involving displacement by azide, partial deace

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11

da Silva, Emerson Teixeira, Adriele da Silva Araújo, Adriana Marques Moraes, and Marcus Vinícius Nora de Souza. "Multigram-scale Synthesis of Building Block Nitro-imine Derivative by Using Classical Method and Ultrasound Irradiation and Conversion to Imino-alcohol Derivative, Using Camphor as Starting Material." Letters in Organic Chemistry 17, no. 3 (2020): 165–69. http://dx.doi.org/10.2174/1570178616666190123114922.

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This study describes a simple multigram-scale procedure for the preparation of (E)-N-(1,7,7- trimethylbicyclo[2.2.1]heptan-2-ylidene)nitramide, nitro-imine 2, by using both classical methods and ultrasound irradiation from 1 utilizing Camphor, a natural product, as starting material. This key intermediate 2, a good building block, is useful to prepare various substances such as terpenoids, reagents for large-scale hydroxylation and amination of organic substrates, and derivatives with anticonvulsant, hypoglycemic, anti-inflammatory, antimicrobial and antiviral activities. It can be transformed

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12

Makhsumov Abdulhamid and Auesbaev Alisher. "SYNTHESIS AND PROPERTIES OF THE DIPROPARGYL DIETER DERIVATIVE 2-BROMINE-2- NITRO-PROPANDIOL-1,3 (BRONOPOL)." International Academy Journal Web of Scholar, no. 12(42) (December 30, 2019): 3–12. http://dx.doi.org/10.31435/rsglobal_wos/30122019/6839.

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    The article is devoted to a comprehensive study of 2-bromo-2-nitro- propanediol - 1,3 (bronopol) in order to expand the derivatives of bronopol as food products, preservatives, in all sectors of the national economy. The derivatives of dipropargyl diester 2 - bromo -, 2 - nitro - propanediol - 1,3, γ,γ ́-dicopper (2-bromo-,2-nitro-dipropargyl diester) propanediol-1,3 (II), γ,γ ́-bis- (silver 2-bromo-, 2-nitro-dipropargyl ether) - propanediol-1,3 (III), mercury-bis- (propargyl ether) - 2 - bromo-, 2- nitro-propanediol - 1, 3 (IV), (γ,γ ́-dibromo-dipropargyl diester)

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13

Patel, H. S., and H. D. Desai. "Synthesis of Some New Azetidinone Derivatives Containing Aryl Sulfonyloxy Group." E-Journal of Chemistry 1, no. 4 (2004): 194–98. http://dx.doi.org/10.1155/2004/258752.

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Some novel azetidinone derivatives containing aryl sulfonyloxy group have been prepared. The 4-sulfonyloxy aniline derivative (2) has been prepared by reaction of 4-nitro phenol (sodium salt) with N-acetyl sulfanilyl chloride (ASC) followed by hydrolysis by ethanolic HCl. This compound (2) undergoes facile condensation reaction with aromatic aldehydes to yield different Schiff’s bases (3a-h). Cyclocondensation of compounds (3a-h) with chloro acetyl chloride yields different 2-azetidinone derivatives (4a-h).

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14

Coulibaly, Songuigama, Jean-Paul D. U. N'Guessan, Jean-Fabrice K. Koffi, Soro T. Grâce, and Mahama Ouattara. "Synthesis of Some 5-nitro Heteroaryl-phenylpropenones with Antituberculosis." Oriental Journal Of Chemistry 40, no. 6 (2024): 1555–61. https://doi.org/10.13005/ojc/400605.

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The treatment of tuberculosis (TB) faces several challenges, such as the emergence of drug-resistant TB, long treatment duration, management of latent TB, and toxic adverse effects leading to non-compliance with treatment. To address this, WHO encourages the search for new molecules that are more effective and better tolerated. In this context, hybrid molecules of the 5-nitro heteroaryl-phenylpropenone type have been designed as new anti-tuberculosis drugs. These compounds were developed by molecular hybridization, combining a pentagonal 5-nitro heteroaryl with a phenylpropenone functional cha

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15

Horáčková, Jaroslava, and Vojeslav Štěrba. "Coupling Kinetics of Benzenediazonium Ions with 2,6-Dioxo-3-(p-substituted phenylhydrazono)-1,2,3,6-tetrahydropyridine-4-carboxylic Acid." Collection of Czechoslovak Chemical Communications 57, no. 9 (1992): 1915–27. http://dx.doi.org/10.1135/cccc19921915.

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The kinetics have been measured of the reactions of 4-nitro-, 4-chloro-, and 4-methoxybenzenediazonium ions with substituted phenylazo derivatives of citrazinic acid in buffer solutions, and the pKa values of the corresponding monoazo and bisazo compounds have been estimated. The reactions of 4-nitrobenzenediazonium ion with 4-chloro- and 4-methoxyphenylazo derivatives and of 4-chlorobenzenediazonium ion with 4-methoxyphenylazo derivative were accompanied by a partial replacement of the substituted phenylazo group by the 4-nitro- and 4-chlorophenylazo groups, respectively. The reactions of 4-c

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16

Bičák, Vojtěch, Alan Liška, and Jiří Ludvík. "Stereoelectrochemistry of Tetranitrocalix[4]arenes." Chemické listy 118, no. 7 (2024): 359–67. http://dx.doi.org/10.54779/chl20240359.

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The present article reveals the differences in voltammetric reduction curves of isomeric nitrocalix[4]arenes (a kind of their “fingerprints”). This observation represents a contribution to a newly introduced utilization of electrochemical approach called “stereoelectrochemistry” and extends the knowledge on these polycyclic molecules. In stereoelectrochemistry, the electrochemical data (potentials and their shifts, number of individual redox steps, proportions of their currents, reversibility etc.) in correlation with a series of derivatives can offer important information concerning the shap

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17

Dr., Sonali Banpure* Bhalekar Pournima Ingale Pramod Matade Siddhesh Mhase Pratiksha. "Design, In Silico Evaluation, Synthesis and Biological Evaluation Of 4-Nitroimidazole Derivatives." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 1621–27. https://doi.org/10.5281/zenodo.15381646.

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This study aimed to design and evaluate novel antitubercular agents using computational methods. Four derivatives of isoniazid and acyclovir were designed and subjected to molecular docking studies against the 3IX2 protein. The results showed that the first derivative had the lowest binding energy (-11.58) and formed three hydrogen bonds with the protein. ADMET analysis was performed to evaluate the pharmacokinetic properties of the designed compounds. Based on the molecular docking and ADMET analysis, the first derivative was identified as the most promising compound for further development a

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18

Okoli, Bamidele, та Johannes Modise. "Investigation into the Thermal Response and Pharmacological Activity of Substituted Schiff Bases on α-Amylase and α-Glucosidase". Antioxidants 7, № 9 (2018): 113. http://dx.doi.org/10.3390/antiox7090113.

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The emphasis of previous studies has targeted the development of insulin mimic with little attention given to the development of metabolic enzyme inhibitors. Our focus is to synthesise nine o-hydroxy and p-nitro-azomethine analogues, investigate their digestive enzyme inhibitory capacity, as well as the antioxidant and antimicrobial activities. The substituted Schiff bases were analysed using thermal gravimetric analyser (TGA), X-ray diffractometer (XRD), nuclear magnetic resonance spectroscopy (NMR), elemental analyser, and Fourier-transform infrared spectroscopy (FT-IR). Determination of syn

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19

Sono, Masakazu, Yui Yamashita, Mayu Hirai, Yayoi Nishio, Shigeru Takaoka, and Motoo Tori. "One-Electron Oxidation of Geranyl Acetone Derivatives Using Ceric(IV) Ammonium Nitrate and Manganese(III) Acetate: Carbon–Carbon Bond Formation." Natural Product Communications 17, no. 7 (2022): 1934578X2211094. http://dx.doi.org/10.1177/1934578x221109424.

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Oxidation of geranyl acetone derivatives with ceric ammonium nitrate (CAN) and Mn(OAc)3 afforded tricyclic and bicyclic compounds as well as hydroxy and nitro compounds as a result of one-electron oxidation followed by carbon–carbon bond formation. This is the first example of radical cyclization (formed by one-electron oxidation) of geranyl acetone derivative 1 and its isomer 4 to give tri- and bicyclic products with carbon–carbon bond formation.

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Sarah Mohammed Abed and Hasan Thamer Ghanem. "Synthesis and characterization Some of heterocyclic compounds from Nitrogen derivative." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (2019): 3186–96. http://dx.doi.org/10.26452/ijrps.v10i4.1621.

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This paper involves the synthesis of new oxazepine derivatives by multi-reaction steps. The first step synthesis azo derivative from 2-naphthol with 3-aminoacetophenone. The second step was the condensation reaction between ketone group of the azo compound and different primary aromatic amines (4-amino phenol, 3-nitro aniline and 4-methyl aniline) to yiled new azo Schiff base compounds (S1-S3) respectively. In the final step, Oxazepine compounds (L1-L3)and (L4-L6)were prepared from reaction imine compounds (S1-S3) with maleic and phthalic anhydride in toluene as solvent. All these derivatives

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21

Valík, Martin, Bohumil Dolensky, Hana Petříčková, and Vladimír Král. "Regio- and Stereoselectivity in Preparation of Benzene Bridged Bis- and Tris-Tröger's Bases." Collection of Czechoslovak Chemical Communications 67, no. 5 (2002): 609–21. http://dx.doi.org/10.1135/cccc20020609.

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Synthetic strategy for novel multiple Tröger's base derivatives is presented. Compounds were prepared in three steps: o-nitrobenzoylation of benzene-1,2- and -1,3-diamines 3 followed by reduction of nitro and amide groups to amino functions and treatment of the obtained tetraamine compounds 6 with formaldehyde lead to simultaneous formation of bis-Tröger's base (bisTB) derivatives 7a, 7b. Only products of 1,2,3,4-substituted regioisomers with anti conformation were separated from reaction mixtures. The same synthetic procedure was used for preparation of tris-Tröger's base (trisTB) derivative

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22

M. Patel, Dhaval, Nirmal K. Patel, Swati Narolkar, and Arvnabh Mishra. "In silico Studies and Assessment of Antimicrobial Activities for Synthesised Nitrobenzimidazole Derivetives." Oriental Journal Of Chemistry 38, no. 2 (2022): 432–38. http://dx.doi.org/10.13005/ojc/380227.

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Nitro substituted benzimidazole derivatives were synthesized using o-phenylenediamine and different aromatic acid. The reaction is carried out in ethanol as solvent at room temperature by using mechanical stirrer. Nitration of the synthesized benzimidazole derivative was carried out using mixed acid as a nitrating agent. The synthesized product characterized by using FT-IR, and 1H NMR. The synthesized benzimidazole derivative were studied for antimicrobial activity using gram -ve and gram +ve micro-organism. Maximum zone of inhibition is 18mm for B. cereus gram +ve microorganism and 17 mm for

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23

Berber, Nurcan, Mustafa Arslan, Emre Yavuz, Cigdem Bilen, and Nahit Gencer. "Synthesis and Evaluation of New Phthalazine Urea and Thiourea Derivatives as Carbonic Anhydrase Inhibitors." Journal of Chemistry 2013 (2013): 1–8. http://dx.doi.org/10.1155/2013/742178.

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A new series of phthalazine substituted urea and thiourea derivatives were synthesized, and their inhibitory effects on the activity of purified human carbonic anhydrases (hCAs I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative(1)was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and nitro group was reduced to amine derivative(2)with SnCl2·2H2O. The compound was reacted with isocyanates and isothiocyanates to get the final products(3a–p). The results showed that all the synthesized compounds inhibited the CA isoenzymes act

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24

do Nascimento, Mayara S. S., Vitória R. F. Câmara, Juliana S. da Costa, et al. "Identification of Novel Functionalized Carbohydrazonamides Designed as Chagas Disease Drug Candidates." Medicinal Chemistry 16, no. 6 (2020): 774–83. http://dx.doi.org/10.2174/1573406415666190627103013.

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Background:: Although several research efforts have been made worldwide to discover novel drug candidates for the treatment of Chagas disease, the nitroimidazole drug benznidazol remains the only therapeutic alternative in the control of this disease. However, this drug presents reduced efficacy in the chronic form of the disease and limited safety after long periods of administration, making it necessary to search for new, more potent and safe prototypes. Objective:: We described herein the synthesis and the trypanocidalaction of new functionalized carbohydrazonamides (2-10) against trypomast

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Blasco, Rafael, Edward Moore, Victor Wray, Dietmar Pieper, Kenneth Timmis, and Francisco Castillo. "3-Nitroadipate, a Metabolic Intermediate for Mineralization of 2,4-Dinitrophenol by a New Strain of aRhodococcus Species." Journal of Bacteriology 181, no. 1 (1999): 149–52. http://dx.doi.org/10.1128/jb.181.1.149-152.1999.

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ABSTRACT The bacterial strain RB1 has been isolated by enrichment cultivation with 2,4-dinitrophenol as the sole nitrogen, carbon, and energy source and characterized, on the basis of 16S rRNA gene sequence comparison, as a Rhodococcus species closely related toRhodococcus opacus. Rhodococcus sp. strain RB1 degrades 2,4-dinitrophenol, releasing the two nitro groups from the compound as nitrite. The release of nitro groups from 2,4-dinitrophenol occurs in two steps. First, the 2-nitro group is removed as nitrite, with the production of an aliphatic nitro compound identified by 1H nuclear magnet

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Su, Yue, Wei Shi, Xin Chen, Shiyu Zhao, Yonghai Hui, and Zhengfeng Xie. "An aggregation-induced emission enhancement fluorescent benzoxazine-derived macromolecule: catalyst-free synthesis and its preliminary application for the determination of aqueous picric acid." RSC Advances 6, no. 47 (2016): 41340–47. http://dx.doi.org/10.1039/c6ra06942h.

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An aggregation-induced emission enhancement macromolecular benzoxazine derivative was synthesized by a catalyst-free Mannich reaction and showed a fluorescence quenching response towards nitro compounds.

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Swellmeen, Lubna, Amal Uzrail, Rand Shahin, and Yusuf AL-Hiari. "Synthesis of Fluoroquinolones Derivatives as Antimicrobial Agents." Oriental Journal Of Chemistry 35, no. 4 (2019): 1248–53. http://dx.doi.org/10.13005/ojc/350401.

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Fluoroquinolones are well known to have an anti-infective action. In the present study we described the synthesis of novel florouquinolones derivative as antimicrobial agent. The biological test highlighted a good inhibitory activity for the 7-Chloro-1-Alkyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derived synthons especially against pathogenic Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Streptococcus agalactiae). The binding interactions were monitored and could explain the good inhibitory activity of the synthesiz

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Guerra, Felipe Queiroga Sarmento, Rodrigo Santos Aquino de Araújo, Janiere Pereira de Sousa, et al. "Evaluation of Antifungal Activity and Mode of Action of New Coumarin Derivative, 7-Hydroxy-6-nitro-2H-1-benzopyran-2-one, againstAspergillusspp." Evidence-Based Complementary and Alternative Medicine 2015 (2015): 1–8. http://dx.doi.org/10.1155/2015/925096.

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Aspergillusspp. produce a wide variety of diseases. For the treatment of such infections, the azoles and Amphotericin B are used in various formulations. The treatment of fungal diseases is often ineffective, because of increases in azole resistance and their several associated adverse effects. To overcome these problems, natural products and their derivatives are interesting alternatives. The aim of this study was to examine the effects of coumarin derivative, 7-hydroxy-6-nitro-2H-1-benzopyran-2-one (Cou-NO2), both alone and with antifungal drugs. Its mode of action againstAspergillusspp. Cou

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Panagopoulos, Anastasios, Konstantina Alipranti, Kyriaki Mylona, et al. "Exploration of the DNA Photocleavage Activity of O-Halo-phenyl Carbamoyl Amidoximes: Studies of the UVA-Induced Effects on a Major Crop Pest, the Whitefly Bemisia tabaci." DNA 3, no. 2 (2023): 85–100. http://dx.doi.org/10.3390/dna3020006.

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The DNA photocleavage effect of halogenated O-carbamoyl derivatives of 4-MeO-benzamidoxime under UVB and UVA irradiation was studied in order to identify the nature, position, and number of halogens on the carbamoyl moiety that ensure photoactivity. F, Cl, and Br-phenyl carbamate esters (PCME) exhibited activity with the p-Cl-phenyl derivative to show excellent photocleavage against pBR322 plasmid DNA. m-Cl-PCME has diminished activity, whereas the presence of two halogen atoms reduced DNA photocleavage. The substitution on the benzamidoxime scaffold was irrelevant to the activity. The mechani

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Anguera, Gonzalo, Maria C. Llinàs, Xavier Batllori, and David Sánchez-García. "Aryl nitroporphycenes and derivatives: first regioselective synthesis of dinitroporphycenes." Journal of Porphyrins and Phthalocyanines 15, no. 09n10 (2011): 865–70. http://dx.doi.org/10.1142/s1088424611003744.

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The nitration reaction of 2,7,12,17-tetraphenylporphycene has been studied. The use of AgNO3 and a mixture of acetic acid and 1,2-dichloroethane as a mild nitrating system provides an optimized preparation of 9-nitro-2,7,12,17-tetraphenylporphycene and a regioselective synthesis of 9,20-dinitro-2,7,12,17-tetraphenylporphycene. While 25 min of reaction are needed to obtain the mononitrated compound, 4 h are necessary to yield a mixture of 9,20-dinitro and 9,19-dinitro 2,7,12,17- tetraphenylporphycene in a proportion of 3 to 1. From this mixture, the geometric isomers can be isolated by fraction

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Alaraby Salem, M., and Alex Brown. "Two-photon absorption of fluorescent protein chromophores incorporating non-canonical amino acids: TD-DFT screening and classical dynamics." Physical Chemistry Chemical Physics 17, no. 38 (2015): 25563–71. http://dx.doi.org/10.1039/c5cp03875h.

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Ito, Akitaka, Yasuyuki Kuroda, Kento Iwai, Soichi Yokoyama, and Nagatoshi Nishiwaki. "Highly electron-deficient 1-propyl-3,5-dinitropyridinium: evaluation of electron-accepting ability and application as an oxidative quencher for metal complexes." RSC Advances 14, no. 9 (2024): 5846–50. http://dx.doi.org/10.1039/d4ra00845f.

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Owing to enhanced electron-accepting/oxidizing abilities, a N-propylpyridinium derivative with two electron-withdrawing nitro groups efficiently quenched emission from Ru(ii) and Ir(iii) complexes by electron transfer.

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33

Kavaliauskas, Povilas, Waldo Acevedo, Andrew Garcia, et al. "Exploring the potential of bis(thiazol-5-yl)phenylmethane derivatives as novel candidates against genetically defined multidrug-resistant Staphylococcus aureus." PLOS ONE 19, no. 3 (2024): e0300380. http://dx.doi.org/10.1371/journal.pone.0300380.

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Antimicrobial resistance (AMR) represents an alarming global challenge to public health. Infections caused by multidrug-resistant Staphylococcus aureus (S. aureus) pose an emerging global threat. Therefore, it is crucial to develop novel compounds with promising antimicrobial activity against S. aureus especially those with challenging resistance mechanisms and biofilm formation. Series of bis(thiazol-5-yl)phenylmethane derivatives were evaluated against drug-resistant Gram-positive bacteria. The screening revealed an S. aureus-selective mechanism of bis(thiazol-5-yl)phenylmethane derivatives

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34

Chihab, Abdelali, Nabil El Brahmi, and Saïd El Kazzouli. "Synthesis, Characterization, and Docking Study of a Novel Indole Derivative Containing a Tosyl Moiety as Anti-Oxidant Agent." Molbank 2024, no. 3 (2024): M1857. http://dx.doi.org/10.3390/m1857.

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Indole derivatives are key components of natural products and possess a wide range of biological and pharmaceutical applications. Here, we present the synthesis of a new indole derivative, namely 2-(1-ethyl-5-nitro-1H-indole-7-carbonyl)butyl 4-methylbenzenesulfonate. The structural elucidation of this compound was accomplished through comprehensive spectroscopic analysis, including Fourier-transform infrared spectroscopy (FTIR), nuclear magnetic resonance (NMR), and high-resolution mass spectrometry (HRMS). Our molecular docking study revealed that this compound exhibits strong affinity toward

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FERNANDES, PATRICK F., and DIVYA R. MISHRA. "A Novel Sensor from Cyclotriveratrylene Derivative for Rapid Detection of 4-Nitrophenol Based on Fluorescence." Asian Journal of Chemistry 32, no. 9 (2020): 2139–42. http://dx.doi.org/10.14233/ajchem.2020.22720.

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In order to study various environmental pollutants among the class of nitro aromatic compounds, a new and novel sensor derived from a cyclotriveratrylene derivative has been developed which rapidly detects 4-nitrophenol from among the class of nitro aromatic compounds via spectrofluorimetric method. The newly derrivaritized cyclotriveratrylene compound is successfully confirmed by using the available techniques of 1H NMR, 13C NMR and ESI-MS. The newly developed molecule was named 4C7NbF-CTV. The complexation behaviour of 4C7NbF-CTV with various nitro aromatic compounds was studied. In the abso

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Dai, Yuyu, Xiaoqing Li, Likai Wang, and Xiangsheng Xu. "Highly efficient hydrogenation reduction of aromatic nitro compounds using MOF derivative Co–N/C catalyst." New Journal of Chemistry 45, no. 48 (2021): 22908–14. http://dx.doi.org/10.1039/d1nj04139h.

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A unique MOF derivative core–shell Co–N/C catalyst exhibits porous structure with high specific area, high cobalt content (23%) and high nitrogen content (3%), resulting in the excellent hydrogenation reduction of nitro compounds.

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37

Parcha, Versha, and Jaswinder Kaur. "Synthesis and biological evaluation of new aryl substituted Schiff’s bases." Pharmaceutical and Biological Evaluations 4, no. 6 (2017): 252. http://dx.doi.org/10.26510/2394-0859.pbe.2017.39.

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Objective: Chemical substances employed to treat various infections caused by various types of microorganism are termed as antimicrobials and natural chemical compounds produced by specific types of bacteria are termed as antibiotics. Unlimited use of antibiotics in humans and animals and in areas other than the treatment and prophylaxis of disease have resulted in a serious problem of drug resistance. Various attempts have been adopted to cope with the resistance problem and enhance the activity, or broaden the spectrum of drugs. Based on structure-activity relationship synthesis of new compo

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38

Huppatz, JL. "Systemic Fungicides. The Synthesis of Pyrazolo[1,5-a]pyrimidine Analogues of Carboxin." Australian Journal of Chemistry 38, no. 1 (1985): 221. http://dx.doi.org/10.1071/ch9850221.

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The synthesis of a series of pyrazolo [1,5-a] pyrimidine derivatives, structural analogues of the systemic fungicide carboxin, is described. A common intermediate incorporating structural features desirable for fungicidal activity, N-phenyl-3(5)-amino-5(3)-methylpyrazole-4- carboxamide (6), was used to prepare pyrazolo [1,5-a] pyrimidines variously substituted in positions 5 and 7 of the ring system. Bromination of N-phenyl-2-methylpyrazolo[1,5-a]pyrimidine-3-carboxamide (8) occurred preferentially in the phenyl ring and the 6-bromo derivative was prepared by bromination of the corresponding 3

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39

Hu, Xiaojun, Zhongliang Zhu, Tianxiang Shen, Xianfa Shi, Jie Ren, and Qiuhong Sun. "Synthesis of the tetranitro derivative of thiacalix[4]arene and its acidbase properties." Canadian Journal of Chemistry 82, no. 8 (2004): 1266–70. http://dx.doi.org/10.1139/v04-090.

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The tetranitro derivative 3 of thiacalix[4]arene was synthesized and characterized. Its acidbase properties in water solution were studied by UV spectroscopy. The four pKa values of 3 were determined by target testing factor analysis (TTFA). The pure UV absorption curves and pH distribution curves of five forms of 3 presented in aqueous solution were also calculated by TTFA.Key words: thiacalixarene, nitro derivative, acidbase properties.

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40

ABBAS, MUREED, SHUMAILA KIRAN, GHULAM HUSSAIN, TAHSIN GULZAR, and MIRZA NADEEM AHMAD. "Synthesis and characterization of novel resorcinol based trisazo reactive dye ligand and its different metal complexes for cotton dyeing." Industria Textila 73, no. 04 (2022): 460–67. http://dx.doi.org/10.35530/it.073.04.202251.

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The goal of this study was to create a new trisazo reactive dye ligand from 6-nitro-2-aminophenol-4-sulphonic acid, resorcinol derivative, and vinyl sulphone para ester, as well as their metal complexes with Fe (II), Ni (II), Cu (II), and Zn (II). The diazotization of 6-nitro-2-aminophenol-4-sulphonic acid was followed by coupling to resorcinol in an alkaline medium for the synthesis of a mono-azo dye ligand. To make reactive dye, diazotized vinyl sulphone para ester was coupled with 6-nitro-2-aminophenol-4-sulphonic acid resorcinol derivative in an alkaline medium. Metal complexes of reactive

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41

Haj Hossein Javaheri, Faezeh, Hossein Ghafouri, and Zeinab Piravar. "The cytotoxic effects of a bioactive nitro derivative of pyrimidine to human breast cancer (MCF-7) cells." Journal of Biological Studies 5, no. 1 (2022): 113–19. http://dx.doi.org/10.62400/jbs.v5i1.6387.

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Breast cancer is one of the leading causes of mortality among women worldwide mostly due to resistance to existing chemotherapeutic agents. In this study, a bioactive nitro derivative of pyrimidine compound 2,6-Diamino-5-((5-methylisoxazole-3-yl) diazenyl) pyrimidin-4-0l was synthesized by the condensation reaction under reflux conditions. Characteristics and structure of synthesized compound was confirmed by the FT-IR,C-NMR and H-NMR analyzes. The cytotoxic effect of the compound was measured by MTT assay at various concentrations (5-100 μg/ml) on breast cancer MCF-7 cells. The MTT results in

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42

Bistocchi, Giovanni Allunni, Giovanni De Meo, Mauro Pedini, Adolfo Ricci, and Pierre Jacquignon. "Alkylating activity of polyphosphate ester in the course of the synthesis of benzimidazoles." Collection of Czechoslovak Chemical Communications 50, no. 9 (1985): 1959–61. http://dx.doi.org/10.1135/cccc19851959.

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5-Fluoro-2-(5-nitrofuryl)benzimidazole (I) was synthesized from 4-fluoro-1,2-diaminobenzene and 5-nitro-2-furoic acid using ethyl polyphosphate as cyclization reagent. N-Ethyl derivative was isolated as by-product in substantial amount.

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43

Podlaha, Jaroslav, Ivana Císařová, Ludmila Soukupová, and Jan Schraml. "Molecular and Crystal Structure of Benzohydroxamic Acid and Its Ring-Substituted Derivatives." Collection of Czechoslovak Chemical Communications 65, no. 8 (2000): 1273–88. http://dx.doi.org/10.1135/cccc20001273.

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Crystal structure of benzohydroxamic acid and its ring-substituted derivatives RC6H4C(O)NHOH (R = 4-Me, 4-NO2, 4-Cl, 3-Cl and 2-Cl) was determined by single-crystal X-ray diffraction. In all the compounds, the hydroxamic group is in the planar amide form and the structures differ mainly in the tilt of the aromatic and hydroxamic acid planes. For the 2-chloro derivative, the dihedral angle of the two planes is 46.1° which corresponds to the intramolecular van der Waals contact of the ortho-substituents. In other compounds, the tilt originates from intermolecular hydrogen bonding and varies betw

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44

Минакова, А. А., and С. Г. Ильясов. "PROPELLANS – PERSPECTIVE FRAME COMPOUNDS FOR THE CREATION OF HIGH-ENERGY SUBSTANCES." Южно-Сибирский научный вестник, no. 5(39) (October 31, 2021): 91–95. http://dx.doi.org/10.25699/sssb.2021.39.5.003.

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Гетероциклические соединения вызывают большой интерес у исследователей как потенциальные соединения в создании биологически активный веществ или веществ с высокой энергией. 3,7,10-Триоксо-2,4,6,8,9,11-гексааза[3.3.3]пропеллан (ТНАР) состоит из трех конденсированных колец, соединенных одинарной связью C1-C5 является новым, малоизученным веществом, синтезированным во втором десятилетии XXI века. Теоретические расчеты энергий нитропроизводных пропелланов с пятью или шестью атомами азота показали перспективность использования в качестве высокоэнергетических веществ. Целью работы было проведение кв

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45

Liu, Beibei, Kun Wang, Hao Lu, Mingming Huang, and Jiping Yang. "A nitro-capped tetraaniline derivative with AIE features for BSA detection and the selective imaging of Gram-positive bacteria." New Journal of Chemistry 43, no. 30 (2019): 11816–20. http://dx.doi.org/10.1039/c9nj02159k.

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A nitro-capped tetraaniline derivative (NO2-B3-Ani4-NO2) with AIE feature was synthesized and characterized, which presented an ultrasensitive turn-on response towards bovine serum albumin and selective imaging of Gram-positive bacteria based on AIE mechanism.

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46

Azad, Chandra S., Vishal M. Balaramnavar, Imran A. Khan, Pawan K. Doharey, Jitendra K. Saxena, and Anil K. Saxena. "Operative conversions of 3-carboxy-4-quinolones into 3-nitro-4-quinolones via ipso-nitration: potential antifilarial agents as inhibitors of Brugia malayi thymidylate kinase." RSC Advances 5, no. 100 (2015): 82208–14. http://dx.doi.org/10.1039/c5ra18036h.

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An efficient, cost effective and green methodology for ipso nitration in the synthesis of the 3-nitro derivative of 3-carboxy 4-quinolones has been developed by the quantitative use of copper acetate and silver nitrate in water.

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47

Mikra, Chrysoula, Maria Bairaktari, Marina-Theodora Petridi, Anastasia Detsi, and Konstantina C. Fylaktakidou. "Green Process for the Synthesis of 3-Amino-2-methyl-quinazolin-4(3H)-one Synthones and Amides Thereof:DNA Photo-Disruptive and Molecular Docking Studies." Processes 10, no. 2 (2022): 384. http://dx.doi.org/10.3390/pr10020384.

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Eleven 3-amino-2-methyl-quinazolin-4(3H)-ones have been synthesized, in good to excellent yields, via their corresponding benzoxazinones using an efficient tandem microwave-assisted green process. Representative acetamides have been thermally derived from their functional free 3-amino group, whereas for the synthesis of various arylamides, a novel green microwave-assisted protocol has been developed, which involved the attack of hydrazides on benzoxazinones. Eight out of the eleven 3-amino-2-methyl-quinazolin-4(3H)-ones were found photo-active towards plasmid DNA under UVB, and four under UVA

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48

CORTES, H. C. E., N. MUELLER, M. ESPOSITO, A. LEITÃO, A. NAGULESWARAN, and A. HEMPHILL. "In vitro efficacy of nitro- and bromo-thiazolyl-salicylamide compounds (thiazolides) against Besnoitia besnoiti infection in Vero cells." Parasitology 134, no. 7 (2007): 975–85. http://dx.doi.org/10.1017/s0031182007002417.

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SUMMARYNitazoxanide (NTZ) and its deacetylated metabolite tizoxanide (TIZ) exhibit considerable in vitro activity against Besnoitia besnoiti tachyzoites grown in Vero cells. Real-time-PCR was used to assess B. besnoiti tachyzoite adhesion, invasion, and intracellular proliferation in vitro. A number of NTZ-derivatives, including Rm4822 and Rm4803, were generated, in which the thiazole-ring-associated nitro-group was replaced by a bromo-moiety. We here show that replacement of the nitro-group on the thiazole ring with a bromo (as it occurs in Rm4822) does not impair the efficacy of the drug, bu

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Morzycki, Jacek W., Agnieszka Gryszkiewicz, Zenon Lotowski та Wojciech J. Szczepek. "Reduction of 2-Nitro-5α-cholestan-3-one, Its Enol Tautomer and 2-Nitro-5α-cholest-2-en-3-amine Derivatives. Synthesis of Bis-Steroidal Pyrazines". Collection of Czechoslovak Chemical Communications 63, № 10 (1998): 1589–96. http://dx.doi.org/10.1135/cccc19981589.

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Reduction of 2α-nitro-5α-cholestan-3-one (4), its enol tautomer (3a) and 3-acetylamino-2-nitro-5α-cholest-2-ene (2) was studied. The latter compound was reduced with zinc in acetic acid to 3β-acetylamino-5α-cholestan-2-one (8). The similar reaction of 3a or 4 led to 2α-amino-5α-cholestan-3-one (11a), that may be trapped as N-formyl derivative. When crude 11a was subjected to air oxidation, pyrazino[2',3':2,3;5',6':2,3]bis(5α-cholestane) (9) was obtained.

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Neamah, Rawaa, та Shaimaa Adnan. "Study the Biological Activity for Shiff Base and Β – Lactam Compounds that Synthesis and Identification from Pyrimidine Derivatives". International Journal of Pharmaceutical Quality Assurance 11, № 01 (2013): 37–39. http://dx.doi.org/10.25258/ijpqa.11.1.12.

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In This study We are synthesis and characterization of some Schiff base and β- lactam derivatives) by three steps. The First react 2-amino-4-Chloro-6-methyl pyrimidine with 4-amino acetophenone in an acid medium to get shiff base derivative(E)-4-(1-((4-Chloro-6-methyl pyridine-2-yl)imino)ethyl)aniline (1), the second step (1) react with (3,4- dimethoxybenzal dehyde,4-methyl benzaldehyde,4-dimethylamino benzaldehyde,4-bromo benzaldehyde,4–hydroxy benzaldehyde, 4-Nitro benzaldehyde) to get Schiff base derivatives (2-7), the last step (2-7) derivatives react with Chloro acetyl chloride to get –β-

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