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Journal articles on the topic 'Nitrogen-containing heterocyclic compounds'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Mr., Mayur Ashok Patkari, Roshan M. Chaudhari Mr., Hitendra S. Chaudhari Mr., and S. P. Pawar Dr. "A Review on Heterocyclic Compound Containing Anticancer Agent, As A Medicinal Chemistry Perspective." Journal of Advances in Clinical Pharmacology 2, no. 1 (2023): 27–38. https://doi.org/10.5281/zenodo.10279377.

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<i>One of the main causes of death in the globe is cancer. Cancer is caused by gene and protein regulation errors in cells. Despite their side effects, surgery, radiation therapy, and the use of anticancer drugs constitute the contemporary cancer therapy. Heterocyclic chemistry is the general field of study. The article's goal is to cover the most current developments in heterocyclic nitrogen compounds as potential cancer chemotherapeutic agents. Heterocyclics make up more than 80% of new medications, and those that contain nitrogen have better pharmacological effects than those that do not. C

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2

Deep, Aman, PrachI, and Hament Panwar. "THE CHEMISTRY OF HEALING: HETEROATOMIC DERIVATIZATION AND THEIR MEDICINAL APPLICATIONS." Annals of Science and Allied Research 2, no. 1 (2024): 26–37. https://doi.org/10.5281/zenodo.12599903.

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Heterocyclic compounds are gaining attention for their medical and biological applications, with over 90% of new drugs containing them. Among all the heterocyclic molecules, mimics of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The n

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3

Dudhe, Anshu R., Sachinkumar D. Gunjal, Sampath AG, Sushama Rawat, and YY Nandurkar. "An Overview on Nitrogen-containing Heterocyclic Compounds as Anticancer Agents." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 04 (2023): 1296–301. http://dx.doi.org/10.25258/ijpqa.14.4.72.

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Cancer accounts for nearly 10 million losses each year. Among the most prevalent cancer types are breast, lung, colon, rectum, and prostate cancers. Astonishingly, around one-third of cancer-related deaths can be attributed to factors such as tobacco usage, a high body mass index (BMI), alcohol consumption, restricted ingestion of fruits and vegetables, and inadequate bodily bustle. In the field of pharmaceuticals, heteroatoms and heterocyclic compounds frequently assume crucial roles and serve as common structural components in numerous active natural products. Statistically, the majority of

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Shaikh, Ansar R., Mazahar Farooqui, R. H. Satpute, and Syed Abed. "Overview on Nitrogen containing compounds and their assessment based on ‘International Regulatory Standards’." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 424–28. http://dx.doi.org/10.22270/jddt.v8i6-s.2156.

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Heterocyclic compounds have a role in most fields of sciences such as medicinal chemistry, biochemistry also another area of sciences. More than 90% of new drugscontain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. Compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields.Most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant

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Romero-Hernández, Laura L., Ana Isabel Ahuja-Casarín, Penélope Merino-Montiel, Sara Montiel-Smith, José Luis Vega-Báez, and Jesús Sandoval-Ramírez. "Syntheses and medicinal chemistry of spiro heterocyclic steroids." Beilstein Journal of Organic Chemistry 20 (July 24, 2024): 1713–45. http://dx.doi.org/10.3762/bjoc.20.152.

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There is compelling evidence that incorporating a heterocyclic moiety into a steroid can alter its pharmacological and pharmacokinetic properties, driving intense interest in the synthesis of such hybrids among research groups. In this review, we present an overview of recent synthetic methodologies, spanning the period from 2000 to 2023, for the preparation of spiro heterocyclic steroids. The compounds surveyed encompass four-, five-, six-, and seven-membered heterocycles appended to various positions of steroidal backbones, with spirocycles containing oxygen, nitrogen, and sulfur atoms being

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6

Lang, Damanpreet K., Rajwinder Kaur, Rashmi Arora, Balraj Saini, and Sandeep Arora. "Nitrogen-Containing Heterocycles as Anticancer Agents: An Overview." Anti-Cancer Agents in Medicinal Chemistry 20, no. 18 (2020): 2150–68. http://dx.doi.org/10.2174/1871520620666200705214917.

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Background: Cancer is spreading all over the world, and it is becoming the leading cause of major deaths. Today’s most difficult task for every researcher is to invent a new drug that can treat cancer with minimal side effects. Many factors, including pollution, modern lifestyle and food habits, exposure to oncogenic agents or radiations, enhanced industrialization, etc. can cause cancer. Treatment of cancer is done by various methods that include chemotherapy, radiotherapy, surgery and immunotherapy in combination or singly along with kinase inhibitors. Most of the anti-cancer drugs use the c

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7

Depa, Navaneetha, and Harikrishna Erothu. "SYNTHESIS AND BIOLOGICAL ACTIVE COMPOUNDS OF NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS: A REVIEW." RASAYAN Journal of Chemistry 15, no. 03 (2022): 1709–17. http://dx.doi.org/10.31788/rjc.2022.1536924.

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Heterocyclic chemistry has a broad spectrum of applications in our day-to-day life. Heterocyclic compounds contain hetero atoms like oxygen, nitrogen, and sulphur in their structure. Among these atoms, a wide variety of heterocyclic moieties with nitrogen as hetero atoms have considerable physiological properties and useful medical applications. Nitrogen-containing heterocyclic compounds are considered a significant category due to their broad therapeutic applications like antibacterial, antimalarial, anticancer, antifungal, anti-HIV, anti-inflammatory, etc., this review article focuses on nov

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8

Zhu, Yannan, and You Huang. "Organocatalyzed [3+3] Annulations for the Construction of Heterocycles." Synthesis 52, no. 08 (2020): 1181–202. http://dx.doi.org/10.1055/s-0039-1690810.

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Six-membered heterocyclic systems are widely distributed in many natural products and pharmaceuticals, and the construction of highly functionalized six-membered heterocyclic compounds is an important topic in modern organic synthesis. Organocatalyzed [3+3] annulations represents an important method for assembling a substantial variety of six-membered cycles that contain one or more heteroatoms. This review describes the development of organocatalyzed [3+3] annulations for the synthesis of six-membered heterocycles, including organocatalysis using secondary amines, tertiary amines, phosphines,

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Hosseinzadeh, Zahra, Ali Ramazani, and Nima Razzaghi-Asl. "Anti-cancer Nitrogen-Containing Heterocyclic Compounds." Current Organic Chemistry 22, no. 23 (2018): 2256–79. http://dx.doi.org/10.2174/1385272822666181008142138.

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MORI, Yutaka, and Kan KICHI. "Heterocyclic nitrogen-containing compounds in hamanatto." JOURNAL OF THE SOCIETY OF BREWING,JAPAN 80, no. 4 (1985): 278–80. http://dx.doi.org/10.6013/jbrewsocjapan1915.80.278.

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11

Grinevich, Oksana I., Anastasia Yu Sholokhova, and Dmitriy D. Matyushin. "The retention features of nitrogen-containing heterocyclic compounds in reversed-phase and hydrophilic HPLC-MS modes." Сорбционные и хроматографические процессы 24, no. 3 (2024): 373–85. http://dx.doi.org/10.17308/sorpchrom.2024.24/12239.

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Aromatic five- and six-membered nitrogen-containing heterocyclic compounds are biologically active substances and are widely used in biochemistry and medicine. In addition, such compounds are known as ecotoxicants formed during oxidation processes in industrial wastewater. High-performance liquid chromatography-mass spectrometry is widely used to determine nitrogen-containing heterocycles in various complex mixtures. Octadecyl silica gel is the main sorbent for chromatographic separation. However, octadecyl silica gel does not always enable satisfactory separation in the presence of highly pol

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Cano, Jessica R. Gutiérrez, Julio López, Miguel A. Vázquez, David Cruz Cruz, and Clarisa Villegas Gómez. "Trienamines for the Organocatalytic Synthesis of Nitrogen-Containing Heterocycles." Current Organic Chemistry 23, no. 10 (2019): 1078–89. http://dx.doi.org/10.2174/1385272823666190617164651.

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Nitrogen-containing heterocycles (NCH), constitute an important group of molecules, which are widely extended in whole chemical space. These compounds are of great interest due to their diverse biological activities. Currently, many compounds derived from NCH are used as powerful drugs for the treatment of diseases ranging from bactericides to anticancer agents. During last decade, the enantioselective synthesis of numerous heterocyclic compounds has been achieved through the use of chiral organocatalysts. The present contribution explores the application of the aminocatalysis towards the synt

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Akishina, E. A., and Е. А. Dikusar. "Chemical modification of different compounds with nitrogen-containing heterocycles." Proceedings of the National Academy of Sciences of Belarus, Chemical Series 57, no. 3 (2021): 356–84. http://dx.doi.org/10.29235/1561-8331-2021-57-3-356-384.

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Heterocyclic compounds have an extremely important practical application, since many heterocycles are the basis of the most valuable medicinal substances, both natural (vitamins, enzymes, alkaloids, etc.) and synthetic biologically active compounds. The work mainly considers the most relevant directions for various purposes drugs search by modifying known bioactive natural, organoelement and framework compounds with 1,2-azole, oxazole, oxadiazole, thiazole, triazole, pyridine, pyrimidine heterocycles over the past 10 years. Chemical modification makes it possible to increase the water solubili

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Khwaza, Vuyolwethu, Sithenkosi Mlala, Opeoluwa O. Oyedeji, and Blessing A. Aderibigbe. "Pentacyclic Triterpenoids with Nitrogen-Containing Heterocyclic Moiety, Privileged Hybrids in Anticancer Drug Discovery." Molecules 26, no. 9 (2021): 2401. http://dx.doi.org/10.3390/molecules26092401.

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Pentacyclic triterpenoids are well-known phytochemicals with various biological activities commonly found in plants as secondary metabolites. The wide range of biological activities exhibited by triterpenoids has made them the most valuable sources of pharmacological agents. A number of novel triterpenoid derivatives with many skeletal modifications have been developed. The most important modifications are the formation of analogues or derivatives with nitrogen-containing heterocyclic scaffolds. The derivatives with nitrogen-containing heterocyclic compounds are among the most promising candid

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15

Sharma, Praveen Kumar, Andleeb Amin, and M. Kumar. "Synthetic Methods of Medicinally Important Heterocycles-thiazines: A Review." Open Medicinal Chemistry Journal 14, no. 1 (2020): 71–82. http://dx.doi.org/10.2174/1874104502014010071.

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Heterocyclic compounds containing N and S atoms have unique properties so that they can be used as potential reactive materials in pharmacokinetic systems. In medicinal chemistry, the therapeutic applications of nitrogen sulphur heterocycles are well known. Especially, Thiazines attract the attention of chemists due to their great bioactive behavior. The present study is a review of the work carried out by the research community for the synthesis of novel, effective, medicinally important heterocyclic compounds-thiazines.

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16

Liu, Jia-Chun, Suresh Narva, Kang Zhou, and Wen Zhang. "A Review on the Antitumor Activity of Various Nitrogenous-based Heterocyclic Compounds as NSCLC Inhibitors." Mini-Reviews in Medicinal Chemistry 19, no. 18 (2019): 1517–30. http://dx.doi.org/10.2174/1389557519666190312152358.

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At present, cancers have been causing deadly fears to humans and previously unpredictable losses to health. Especially, lung cancer is one of the most common causes of cancer-related mortality accounting for approximately 15% of all cancer cases worldwide. While Non-Small Cell Lung Carcinomas (NSCLCs) makes up to 80% of lung cancer cases. The patient compliance has been weakening because of serious drug resistance and adverse drug effects. Therefore, there is an urgent need for the development of novel structural agents to inhibit NSCLCs. Nitrogen-containing heterocyclic compounds exhibit wide

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17

Li, Yanan, Tao Liu, and Jianan Sun. "Recent Advances in N-Heterocyclic Small Molecules for Synthesis and Application in Direct Fluorescence Cell Imaging." Molecules 28, no. 2 (2023): 733. http://dx.doi.org/10.3390/molecules28020733.

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Nitrogen-containing heterocycles are ubiquitous in natural products and drugs. Various organic small molecules with nitrogen-containing heterocycles, such as nitrogen-containing boron compounds, cyanine, pyridine derivatives, indole derivatives, quinoline derivatives, maleimide derivatives, etc., have unique biological features, which could be applied in various biological fields, including biological imaging. Fluorescence cell imaging is a significant and effective imaging modality in biological imaging. This review focuses on the synthesis and applications in direct fluorescence cell imaging

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El-Sonbati, A. Z., A. A. M. Belal, S. I. El-Wakeel, and M. A. Hussien. "Stereochemistry of new nitrogen containing heterocyclic compounds." Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 60, no. 4 (2004): 965–72. http://dx.doi.org/10.1016/s1386-1425(03)00326-3.

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19

Sharma, Praveen Kumar. "A REVIEW: ANTIMICROBIAL AGENTS BASED ON NITROGEN AND SULFUR CONTAINING HETEROCYCLES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 2 (2017): 47. http://dx.doi.org/10.22159/ajpcr.2017.v10i2.15673.

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At present, heterocyclic compounds and their derived forms have become strong reflection in medicinal research field because of their positive pharmacological and biological properties. Heterocycles are prosperous in nature and have expanded additional importance because their structural subunits are established in many natural products such as antibiotics, vitamins, and hormones. Thiazine moieties present in compounds have multiplicity of medicinal activities such as antihypertensive, antitumor, antimicrobial, antibacterial, anticoagulant, antifungal, anticancer, and antiviral. This review ar

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20

Harith M. Al-ajely. "Synthesis and pharmaceutical applications of Oxazine compounds derived from Pyronic, Salicylic, Antharanilic acids and Phenols." International Journal of Science and Research Archive 2, no. 2 (2021): 074–86. http://dx.doi.org/10.30574/ijsra.2021.2.2.0250.

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It is well known from FDA reports that More than 75% of the heterocyclic compounds are drugs and 90 of heterocyclic compounds are cancer drugs. The nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. Most drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties, More over heterocyclic compounds are important class of organic chemistry due to their widely spread in nature. Also there are many route for their action and many mechanistic pathways for their preparation and d

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Asif, Mohammad. "Biological Potential and Chemical Properties of Pyridine and Piperidine Fused Pyridazine Compounds: Pyridopyridazine a Versatile Nucleus." Asian Journal of Chemistry and Pharmaceutical Sciences 1, no. 1 (2016): 29. http://dx.doi.org/10.18311/ajcps/2016/7693.

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Pyridopyridazine compounds are important nitrogen atom containing heterocyclic compounds due to their pharmacological versatility. This heterocycle system characterized a structural feature for different types of bioactive compounds that exhibiting various types of biological activities which make it an attractive scaffold for the design and development of new drug molecules. This article provided information about the pharmacological properties of pyridopyridazines derivatives.

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Naito, Takeaki. "Heterocycle synthesis via radical reactions." Pure and Applied Chemistry 80, no. 4 (2008): 717–26. http://dx.doi.org/10.1351/pac200880040717.

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A novel synthetic method for the preparation of nitrogen-containing heterocycles via the route involving domino-type radical addition/cyclization reaction of oxime ethers is described. Alkyl radical addition/cyclization of oxime ethers carrying an appropriate leaving group proceeded smoothly to form the alkylated nitrogen-containing heterocyclic compounds. Additionally, tin-mediated radical addition/cyclization/elimination (RACE) reaction of oxime ethers is newly found and successfully applied to an asymmetric total synthesis of (-)-martinellic acid.

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Negi, Beena, and Aarshiya Kwatra. "A Review of Recent Progress on the Anticancer Activity of Heterocyclic Compounds." SynOpen 08, no. 03 (2024): 185–210. http://dx.doi.org/10.1055/s-0040-1720125.

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AbstractCancer is one of the most daunting illnesses in the world as compared to many other human diseases. This review article aims to summarize the literature that is already published based on heterocyclic anticancer compounds. Under this broad topic we try to shed a light on anticancer potentiality of oxygen-, sulfur-, and nitrogen-containing heterocyclic compounds, such as quinolines, pyrroles, pyrimidines, pyridines, indoles, also sulfonamides linked heterocycles, benzimidazoles and oxadiazoles.1 Introduction1.1 Drugs in Use for Cancer Treatment1.2 Recently Discovered Anticancer Drugs2 V

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Foldesi, Tamas, Balazs Volk, and Matyas Milen. "A Review of 2,3-Benzodiazepine-related Compounds: Diazepines and 1,2,5- Triazepines Fused with Five-membered Nitrogen Heterocycles." Current Organic Synthesis 15, no. 6 (2018): 729–54. http://dx.doi.org/10.2174/1570179415666180601101856.

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Background: 2,3-Benzodiazepines represent an important class of biologically active compounds, some members of this family have reached the human clinical stage. With formal bioisosteric replacement of the benzene ring to five-membered nitrogen heterocycles, several new diazepine and 1,2,5-triazepine derivatives have been synthesized in the past 30 years. Objective: Investigations in the field of heterocyclic chemistry is very important, because there could be several new medicines among the newly synthesized heterocyclic ring systems, which could be used against several diseases which have no

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Yang, Anran, Xue Miao, Liu Yang, et al. "N-Amidation of Nitrogen-Containing Heterocyclic Compounds: Can We Apply Enzymatic Tools?" Bioengineering 10, no. 2 (2023): 222. http://dx.doi.org/10.3390/bioengineering10020222.

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Amide bond is often seen in value-added nitrogen-containing heterocyclic compounds, which can present promising chemical, biological, and pharmaceutical significance. However, current synthesis methods in the preparation of amide-containing N-heterocyclic compounds have low specificity (large amount of by-products) and efficiency. In this study, we focused on reviewing the feasible enzymes (nitrogen acetyltransferase, carboxylic acid reductase, lipase, and cutinase) for the amidation of N-heterocyclic compounds; summarizing their advantages and weakness in the specific applications; and furthe

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Larina, Lyudmila. "C- and N-Phosphorylated Enamines—An Avenue to Heterocycles: NMR Spectroscopy." International Journal of Molecular Sciences 24, no. 11 (2023): 9646. http://dx.doi.org/10.3390/ijms24119646.

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The review presents extensive data (from the works of the author and literature) on the structure of C- and N-chlorophosphorylated enamines and the related heterocycles obtained by multipulse multinuclear 1H, 13C, and 31P NMR spectroscopy. The use of phosphorus pentachloride as a phosphorylating agent for functional enamines enables the synthesis of various C- and N-phosphorylated products that are heterocyclized to form various promising nitrogen- and phosphorus-containing heterocyclic systems. 31P NMR spectroscopy is the most convenient, reliable and unambiguous method for the study and iden

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Ebenezer, Oluwakemi, Maryam Amra Jordaan, Gea Carena, Tommaso Bono, Michael Shapi, and Jack A. Tuszynski. "An Overview of the Biological Evaluation of Selected Nitrogen-Containing Heterocycle Medicinal Chemistry Compounds." International Journal of Molecular Sciences 23, no. 15 (2022): 8117. http://dx.doi.org/10.3390/ijms23158117.

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Heterocyclic compounds are a class of compounds of natural origin with favorable properties and hence have major pharmaceutical significance. They have an exceptional adroitness favoring their use as diverse smart biomimetics, in addition to possessing an active pharmacophore in a complex structure. This has made them an indispensable motif in the drug discovery field. Heterocyclic compounds are usually classified according to the ring size, type, and the number of heteroatoms present in the ring. Among different heterocyclic ring systems, nitrogen heterocyclic compounds are more abundant in n

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SERGEEV, A. O., D. V. NOSULYA, A. V. CHERIKOV, D. A. ZABRODA, D. S. KOSYANENKO, and V. M. MOKHOV. "CATALYTIC HYDROGENATION OF PYRIDINE AND QUINOLINE DERIVATIVES." IZVESTIA VOLGOGRAD STATE TECHNICAL UNIVERSITY, no. 5 (300) (May 2025): 7–26. https://doi.org/10.35211/1990-5297-2025-5-300-7-26.

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This article presents a review of catalytic hydrogenation as one of the leading methods for obtaining nitrogen-containing heterocyclic compounds with a reduced ring system, which are valuable products in many industries. Various approaches to the synthesis of these compounds using homo- and heterogeneous catalytic systems and various reducing agents are described, and the main areas of application of reduced N-heterocycles are identified.

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Campanati, M., A. Vaccari, and O. Piccolo. "Environment-friendly synthesis of nitrogen-containing heterocyclic compounds." Catalysis Today 60, no. 3-4 (2000): 289–95. http://dx.doi.org/10.1016/s0920-5861(00)00345-x.

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Dénes, V., and R. Chira. "Polyhalogenation of nitrogen containing heterocyclic compounds. IV. Polybromoquinolines." Journal für Praktische Chemie 333, no. 2 (1991): 351–53. http://dx.doi.org/10.1002/prac.19913330223.

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Solanki, Shivam, and Hardik Bhatt. "Emerging Frontiers in Antimicrobial Therapy: The Role of Nitrogen-Containing Heterocyclic Compounds in Overcoming Drug-Resistant Infections." RESEARCH REVIEW International Journal of Multidisciplinary 10, no. 2 (2025): 97–113. https://doi.org/10.31305/rrijm.2025.v10.n2.011.

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The rise of antibiotic-resistant bacterial pathogens has become a significant public health challenge, necessitating the exploration of novel antimicrobial agents. Nitrogen-containing heterocyclic compounds have emerged as promising candidates in this quest, owing to their diverse and potent antibacterial activities. This review delves into the various mechanisms through which these compounds exert their antibacterial effects, including inhibition of cell wall synthesis, disruption of protein and nucleic acid synthesis, interference with metabolic pathways, membrane disruption, induction of ox

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Ibragimova, Mahliyo. "ANALYSIS OF HETEROCYCLIC COMPOUNDS." "Science and innovation" international scientific journal. ISSN: 2181-3337 1, no. 4 (2022): 266–65. https://doi.org/10.5281/zenodo.6973947.

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<em>This article describes heterocyclic compounds and the classification of their structure. Each atom of an element with two or more valences can participate in the formation of heterocyclic compounds. But among them, the most stable, widespread, well studied and important are heterocyclic compounds containing nitrogen, oxygen and sulfur. The reason for the formation of ring compounds with these atoms and carbon atoms is that the bond angles in the compounds of these atoms are very close to the bond angles of the hybridized C atom (sp 3 hybridization α=1090 and sp 2 hybridization &alpha

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Caiazzo, Aldo, Shadi Dalili, C. Picard, M. Sasaki, T. Siu, and A. K. Yudin. "New methods for the synthesis of heterocyclic compounds." Pure and Applied Chemistry 76, no. 3 (2004): 603–13. http://dx.doi.org/10.1351/pac200476030603.

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Due to frequent occurrence of nitrogen-containing groups among the biologically active compounds, chemoselective functionalization of organic molecules with nitrogen-containing functional groups is an important area of organic synthesis. We have proposed and implemented a new strategy toward design of nitrogen-transfer reactions on inert electrode surfaces with a particular focus on the generation and trapping of highly reactive nitrogen-transfer agents. A wide range of structurally dissimilar olefins can be readily transformed into the corresponding aziridines. The resulting aziridines are pr

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Wang, Libin, Elizabeth A. Baldwin, Zhifang Yu, and Jinhe Bai. "The Impact of Kitchen and Food Service Preparation Practices on the Volatile Aroma Profile in Ripe Tomatoes: Effects of Refrigeration and Blanching." HortScience 50, no. 9 (2015): 1358–64. http://dx.doi.org/10.21273/hortsci.50.9.1358.

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Both refrigeration and blanching of red-stage tomatoes are common practices in Japan home kitchens and in food service operations. However, little is reported on the impact of such practices on aroma profiles in tomato fruits. In this study, ‘FL 47’ tomatoes at red stage were dipped in 50 °C hot water for 5 minutes or exposed to 5 °C for 4 days to simulate consumer handling of tomato in food service or home kitchens, respectively. Of the 42 volatile compounds detected, refrigeration generally suppressed production of aldehydes, alcohols, oxygen-containing heterocyclic compounds, and nitrogen-

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Bąchor, Urszula, та Marcin Mączyński. "Selected β2-, β3- and β2,3-Amino Acid Heterocyclic Derivatives and Their Biological Perspective". Molecules 26, № 2 (2021): 438. http://dx.doi.org/10.3390/molecules26020438.

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Heterocyclic moieties, especially five and six-membered rings containing nitrogen, oxygen or sulfur atoms, are broadly distributed in nature. Among them, synthetic and natural alike are pharmacologically active compounds and have always been at the forefront of attention due to their pharmacological properties. Heterocycles can be divided into different groups based on the presence of characteristic structural motifs. The presence of β-amino acid and heterocyclic core in one compound is very interesting; additionally, it very often plays a vital role in their biological activity. Usually, such

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Kaur, Navjeet, Neha Ahlawat, Yamini Verma, Pooja Grewal, and Pranshu Bhardwaj. "A Review of Ruthenium-catalyzed C-N Bond Formation Reactions for the Synthesis of Five-membered N-heterocycles." Current Organic Chemistry 23, no. 18 (2019): 1901–44. http://dx.doi.org/10.2174/1385272823666191021104118.

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The field of heterocyclic chemistry has been revolutionized using transition metal catalysts in recent years. Various research groups have focused on the development of general protocols to achieve better functional group compatibilities and greater levels of molecular complexity under mild reaction conditions, using easily available starting substrates. The methodologies used earlier for their synthesis were less approachable to organic chemists because of their high cost, highly specified instrumentation and inconvenient methods. For both stereoselective and regioselective synthesis of five-

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Ullah, Faiz, Sami Ullah, Muhammad Farhan Ali Khan, et al. "Fluorescent and Phosphorescent Nitrogen-Containing Heterocycles and Crown Ethers: Biological and Pharmaceutical Applications." Molecules 27, no. 19 (2022): 6631. http://dx.doi.org/10.3390/molecules27196631.

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Fluorescent molecules absorb photons of specific wavelengths and emit a longer wavelength photon within nanoseconds. Recently, fluorescent materials have been widely used in the life and material sciences. Fluorescently labelled heterocyclic compounds are useful in bioanalytical applications, including in vivo imaging, high throughput screening, diagnostics, and light-emitting diodes. These compounds have various therapeutic properties, including antifungal, antitumor, antimalarial, anti-inflammatory, and analgesic activities. Different neutral fluorescent markers containing nitrogen heterocyc

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Badolato, Mariateresa, Francesca Aiello, and Nouri Neamati. "2,3-Dihydroquinazolin-4(1H)-one as a privileged scaffold in drug design." RSC Advances 8, no. 37 (2018): 20894–921. http://dx.doi.org/10.1039/c8ra02827c.

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Kamlar, M., I. Císařová, and J. Veselý. "Alkynylation of heterocyclic compounds using hypervalent iodine reagent." Organic & Biomolecular Chemistry 13, no. 10 (2015): 2884–89. http://dx.doi.org/10.1039/c4ob02625j.

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Ansari, Anam, Abad Ali, Mohd Asif, and Shamsuzzaman Shamsuzzaman. "Review: biologically active pyrazole derivatives." New Journal of Chemistry 41, no. 1 (2017): 16–41. http://dx.doi.org/10.1039/c6nj03181a.

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Larina, Lyudmila I. "The Structure of Biologically Active Functionalized Azoles: NMR Spectroscopy and Quantum Chemistry." Magnetochemistry 8, no. 5 (2022): 52. http://dx.doi.org/10.3390/magnetochemistry8050052.

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This review summarizes the data on the stereochemical structure of functionalized azoles (pyrazoles, imidazoles, triazoles, thiazoles, and benzazoles) and related compounds obtained by multipulse and multinuclear 1H, 13C, 15N NMR spectroscopy and quantum chemistry. The stereochemistry of functionalized azoles is a challenging topic of theoretical research, as the correct interpretation of their chemical behavior and biological activity depends on understanding the factors that determine the stereochemical features and relative stability of their tautomers. NMR spectroscopy, in combination with

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42

Elsaiid, A. E., R. Walker, S. Weeks, A. P. D'Silva, and V. A. Fassel. "Site-Selective Shpol'skii Spectrometry of Sulfur-, Oxygen-, and Nitrogen-Containing Aromatic Compounds in Complex Samples." Applied Spectroscopy 42, no. 5 (1988): 731–40. http://dx.doi.org/10.1366/0003702884428969.

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Laser excited Shpol'skii spectrometry (LESS) was utilized to directly determine nitrogen (N-), oxygen (O-), and sulfur (S-) heterocyclic compounds in solvent refined coal (SRC-II), petroleum crude oil, and carbon black. Characteristic quasilinear LESS excitation and emission spectra of the heterocyclic compounds are presented for the first time under site-selective conditions. Deuterated analogs of dibenzothiophene and dibenzofuran were utilized for quantitation. Site-selective fluorescence spectra of aminopyrene derivatives of polycyclic aromatic compounds (PAC) are also presented for the fir

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Dighe, Varsha A., and Rohini R. Pujari. "Synthesis of some Sulphur and Nitrogen containing Heterocyclic Compounds." Asian Journal of Pharmaceutical Research 7, no. 1 (2017): 21. http://dx.doi.org/10.5958/2231-5691.2017.00004.1.

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Todorovskii, A. T., and S. Ya Plotkin. "Vibrational spectra of nitrogen-containing six-membered heterocyclic compounds." Journal of Applied Spectroscopy 48, no. 3 (1988): 285–90. http://dx.doi.org/10.1007/bf00663294.

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Parshikov, Igor A., Eliane O. Silva, and Niege A. J. C. Furtado. "Transformation of saturated nitrogen-containing heterocyclic compounds by microorganisms." Applied Microbiology and Biotechnology 98, no. 4 (2013): 1497–506. http://dx.doi.org/10.1007/s00253-013-5429-1.

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Kucharski, Mieczys?aw, and Dorota G?owacz-Czerwonka. "Solubilization of nitrogen-containing heterocyclic compounds in reactive solvents." Journal of Applied Polymer Science 84, no. 14 (2002): 2650–59. http://dx.doi.org/10.1002/app.10439.

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Kashman, Yoel, Amira Rudi, and Doron Pappo. "Recent heterocyclic compounds from marine invertebrates: Structure and synthesis." Pure and Applied Chemistry 79, no. 4 (2007): 491–505. http://dx.doi.org/10.1351/pac200779040491.

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A large variety of unique heterocyclic natural marine products, without terrestrial counterparts, have been isolated from marine invertebrates, mainly sponges, ascidians, and soft corals. Many of these compounds display interesting biological activity. In this review, we report our recent studies on nitrogen-containing heterocyclic compounds ("alkaloids"), as well as some containing sulfur and oxygen, which have been isolated from Red Sea and Indo-Pacific organisms, and discuss progress on the synthesis of these natural products and structural analogs.

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Hitesh, Hitesh Amrutlal. "Synthesis, Characterization and Antifungal Activity of Novel Thiazolo-Pyrimidine Fused Heterocycles." ECS Transactions 107, no. 1 (2022): 1165–72. http://dx.doi.org/10.1149/10701.1165ecst.

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In medicinal chemistry, nitrogen and sulphur containing heterocyclic compounds are well known for their therapeutic properties.(1) Among them thiazole and pyrimidine derivatives possess diverse pharmaceutical activities.(2,3) More particularly thiazolo-pyrimidine fused shows various therapeutically activities like, anticancer, antimicrobial, antibacterial effects, antiviral ,etc (4-7). Such type of fused heterocycles containing furan and naphthalene moieties has not been developed. Thus, the aim of the present work to study the novel fused thiazolo-pyrimidine derivatives, their characterizatio

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S., C. JAIN, S. GILL M., and S. RAO G. "Coordination Compounds of Uranium(IV) and Dioxouranium(VI) with Nitrogen-containing Heterocyclic Ligands." Journal of Indian Chemical Society Vol. 63, Feb 1986 (1986): 195–97. https://doi.org/10.5281/zenodo.6253654.

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Chemistry Division, Bhabha Atomic Research Centre, Trombay, Bombay 400 085 <em>Manuscript received 6 August 1984, revised 4 July 1985, accepted 15 November 1985</em> Synthesis and characterisation of the complexes of uranium(IV) and dioxouranium(VI) with imidazole (Imz) pyrazole (Pyz) and trimethylsilane imidazole (Tmi) have been described Compounds of different stoichiometries are obtained depending on the uranium salt and the ligand used The infrared spectral studies (4000 200 cm<sup>-1</sup>) established that in all the complexes, the coordination of the ligand to the metal ion is thro

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De Salvo, Alex, Raffaella Mancuso, and Xiao-Feng Wu. "Carbonylative synthesis and functionalization of indoles." Beilstein Journal of Organic Chemistry 20 (April 30, 2024): 973–1000. http://dx.doi.org/10.3762/bjoc.20.87.

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Carbonylation processes have become widely recognized as a versatile, convenient, and low-cost method for the synthesis of high-value compounds. Given the great importance of heterocyclic compounds, the carbonylative approach has become increasingly important for their synthesis. In this mini-review, as a class of benzo-fused nitrogen-containing heterocyclic compounds, we summarized and discussed the recent achievements on the synthesis and functionalization of indole derivatives via carbonylative approaches.

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