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Journal articles on the topic 'Nitrogen heterocycle synthesis'

Author: Grafiati

Published: 4 June 2021

Last updated: 15 February 2022

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1

Naito, Takeaki. "Heterocycle synthesis via radical reactions." Pure and Applied Chemistry 80, no. 4 (2008): 717–26. http://dx.doi.org/10.1351/pac200880040717.

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A novel synthetic method for the preparation of nitrogen-containing heterocycles via the route involving domino-type radical addition/cyclization reaction of oxime ethers is described. Alkyl radical addition/cyclization of oxime ethers carrying an appropriate leaving group proceeded smoothly to form the alkylated nitrogen-containing heterocyclic compounds. Additionally, tin-mediated radical addition/cyclization/elimination (RACE) reaction of oxime ethers is newly found and successfully applied to an asymmetric total synthesis of (-)-martinellic acid.

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2

Slivka, Mikhailo, and Mikhailo Onysko. "The Use of Electrophilic Cyclization for the Preparation of Condensed Heterocycles." Synthesis 53, no. 19 (2021): 3497–512. http://dx.doi.org/10.1055/s-0040-1706036.

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AbstractCondensed heterocycles are well-known for their excellent biological effects and they are undeniably important compounds in organic chemistry. Electrophilic cyclization reactions are widely used for the synthesis of mono-heterocyclic compounds. This review highlights the utility of electrophilic cyclization reactions as an effective generic tool for the synthesis of various condensed heterocycles containing functional groups that are able to undergo further chemical transformations, such as nucleophilic substitution, elimination, re-cyclization, cleavage, etc. This review describes the

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3

Gupta, Vivek Kumar, Baljeet Kaur, Amandeep Kaur, Amanpreet Kaur, and Monika Gupta. "Synthesis and Biological Evaluation of 1,3,4-Oxadiazolyl benzenesulphonyl benzimidazole derivatives." Indian Journal of Pharmaceutical and Biological Research 6, no. 02 (2018): 64–71. http://dx.doi.org/10.30750/ijpbr.6.2.10.

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Oxadiazoles are a class of heterocyclic aromatic chemical compound of azole family. Oxadiazole is five membered heterocycle having two carbons, two nitrogen, one oxygen and two double bonds. Oxadiazole exists in four isomeric forms depending upon the position of nitrogen atom in the ring. Benzimidazole is a heterocyclic aromatic compound. This bicyclic compound consists of fusion of benzene and imidazole. Benzimidazole may also be considered as cyclic analogues of imidines due to tautomerism effect. In the present study involves synthesis of1,3,4-oxadiazolyl benzenesulphonylbenzimidazole deriv

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4

Sundermeyer, Jörg, Herbert W. Roesky, and Mathias Noltemeyer. "Synthesis of a new unsaturated 16-membered heterocycle with alternating CC and NS building blocks." Canadian Journal of Chemistry 67, no. 11 (1989): 1785–87. http://dx.doi.org/10.1139/v89-276.

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The reaction between C6H4(SCl)23 and (PhC=NSiMe3)24 leads to the 16-membered heterocycle (SC6H4SN=CPhCPh=N)25. The X-ray structure analysis of 5 shows a nonplanar macrocyclic system with alternating CC and NS units. Keywords: 16-membered heterocycle, X-ray structure, sulphur–nitrogen.

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5

Vaughan, Keith, Ronald J. LaFrance, York Tang, and Donald L. Hooper. "Open-chain nitrogen compounds. Part VIII. 1-(2′-Acetylphenyl)-3-alkyltriazenes with reactive substituents in the alkyl group: synthons for five- and six-membered nitrogen heterocycles." Canadian Journal of Chemistry 63, no. 9 (1985): 2455–61. http://dx.doi.org/10.1139/v85-406.

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The synthesis of a series of 1-(2′-acetylphenyl)-3-alkyltriazenes, with electron-withdrawing α-substituents in the alkyl moiety, is described. The structure of the products from the reaction of 2-acetylbenzenediazonium ion (1) with methylamine has been reinvestigated using high field (360 MHz) nmr spectroscopy. The 2-acetylphenyltriazenes undergo cyclization to five-or six-membered heterocycles, depending on the substituent present in the alkyl group. Attack by N-3 of the triazene on the ortho-acetyl group leads to a 4-methylenetriazine, which can undergo oxidation to a benzotriazinone or acid

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6

Mahesh, V. K., Mamta Maheswari, Rakesh Sharma, and Rashmi Sharma. "Analogs of cannabinoids: synthesis of some 7H-indolo-, 5H-imidazolo, 7H-benzimidazolo[1,2-c] [1,3]benzoxazines – novel ring systems." Canadian Journal of Chemistry 63, no. 3 (1985): 632–35. http://dx.doi.org/10.1139/v85-103.

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Tetrahydrocannabinol 1, the active constituent of CannabissativaLinn, is a well-known CNS-active compound and introduction of a nitrogen atom at the ring junction of the pyran and alicyclic ring is of considerable interest. This prompted the synthesis of 7H-indolo[1,2-c] [1,3]-, 5H-imidazolo[1,2-C] [1,3],- and 7H-benzimidazolo[1,2-c] [1,3]-benzoxazine, a novel heterocyclic system. 2-(2′-Hydroxyphenyl) indoles, 2-(2′-hydroxyphenyl) imidazoles, and 2-(2′-hydroxyphenyl) benzimidazoles are suitable intermediates for the preparation of this type of benzoxazines, as the second heterocycle (ring B) c

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7

Philkhana, Satish Chandra, Fatimat O. Badmus, Isaac C. Dos Reis, and Rendy Kartika. "Recent Advancements in Pyrrole Synthesis." Synthesis 53, no. 09 (2021): 1531–55. http://dx.doi.org/10.1055/s-0040-1706713.

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AbstractThis review article features selected examples on the synthesis of functionalized pyrroles that were reported between 2014 and 2019. Pyrrole is an important nitrogen-containing aromatic heterocycle that can be found in numerous compounds of biological and material significance. Given its vast importance, pyrrole continues to be an attractive target for the development of new synthetic reactions. The contents of this article are organized by the starting materials, which can be broadly classified into four different types: substrates bearing π-systems, substrates bearing carbonyl and ot

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8

Duttwyler, S., S. Chen, M. K. Takase, K. B. Wiberg, R. G. Bergman, and J. A. Ellman. "Proton Donor Acidity Controls Selectivity in Nonaromatic Nitrogen Heterocycle Synthesis." Science 339, no. 6120 (2013): 678–82. http://dx.doi.org/10.1126/science.1230704.

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9

Yoshida, Zen-ichi, Hideo Hirai, Sadao Miki, and Shigeo Yoneda. "Trithiocyclopropenium ion as a building block for nitrogen heterocycle synthesis." Tetrahedron 45, no. 10 (1989): 3217–31. http://dx.doi.org/10.1016/s0040-4020(01)80147-2.

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10

Hu, Bao, and Stephen G. DiMagno. "Reactivities of vinyl azides and their recent applications in nitrogen heterocycle synthesis." Organic & Biomolecular Chemistry 13, no. 13 (2015): 3844–55. http://dx.doi.org/10.1039/c5ob00099h.

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This review categorizes the active intermediates generated from denitrogenation of vinyl azides under different reaction conditions, and highlights newly discovered transformations of vinyl azides that lead to convenient syntheses of N-heterocycles.

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11

Zhang, Rui, Kai Lv, Bin Wang, et al. "Design, synthesis and antitubercular evaluation of benzothiazinones containing an oximido or amino nitrogen heterocycle moiety." RSC Advances 7, no. 3 (2017): 1480–83. http://dx.doi.org/10.1039/c6ra25712g.

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A series of 8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-ones (BTZs) bearing an oximido or amino nitrogen heterocycle moiety through modifications at the C-2 position of BTZ043 and BPTZ169 were designed and synthesized as new antitubercular agents.

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12

Hilton, Michael C., Xuan Zhang, Benjamin T. Boyle, Juan V. Alegre-Requena, Robert S. Paton, and Andrew McNally. "Heterobiaryl synthesis by contractive C–C coupling via P(V) intermediates." Science 362, no. 6416 (2018): 799–804. http://dx.doi.org/10.1126/science.aas8961.

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Heterobiaryls composed of pyridine and diazine rings are key components of pharmaceuticals and are often central to pharmacological function. We present an alternative approach to metal-catalyzed cross-coupling to make heterobiaryls using contractive phosphorus C–C couplings, also termed phosphorus ligand coupling reactions. The process starts by regioselective phosphorus substitution of the C–H bonds para to nitrogen in two successive heterocycles; ligand coupling is then triggered via acidic alcohol solutions to form the heterobiaryl bond. Mechanistic studies imply that ligand coupling is an

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13

Zhu, Yannan, and You Huang. "Organocatalyzed [3+3] Annulations for the Construction of Heterocycles." Synthesis 52, no. 08 (2020): 1181–202. http://dx.doi.org/10.1055/s-0039-1690810.

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Six-membered heterocyclic systems are widely distributed in many natural products and pharmaceuticals, and the construction of highly functionalized six-membered heterocyclic compounds is an important topic in modern organic synthesis. Organocatalyzed [3+3] annulations represents an important method for assembling a substantial variety of six-membered cycles that contain one or more heteroatoms. This review describes the development of organocatalyzed [3+3] annulations for the synthesis of six-membered heterocycles, including organocatalysis using secondary amines, tertiary amines, phosphines,

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14

Break, Laila. "Synthesis of the Novel 3-Benzotriazole-5-yl difluoromethyl-5-trifluoromethyl benzotriazole Nucleosides." International Journal of Chemistry 7, no. 2 (2015): 99. http://dx.doi.org/10.5539/ijc.v7n2p99.

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Triazole ring is a quite important five-membered heterocycle with three nitrogen atoms, possesses aromaticity and is an electron rich system. Triazole derivatives have been frequently becoming clinical drugs or candidates for the treatment of various types of diseases. Synthesis of the novel of 3-Benztriazole-5-yl difluoromethyl-5-trifluoromethyl benztriazole compound (3). Synthesis and chara-cterization of two new benzotriazole nucleosides with good yields by silyation method.

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15

Zhu, Wen-Zhong, Rui-Ding Hu, Qiu-Yue Lin, Xiao-Xia Wang, and Xiao-Liang Zheng. "Synthesis, DNA-binding and antiproliferative activity of N-(Nitrogen heterocyclic) norcantharidin acylamide acid." Open Chemistry 7, no. 3 (2009): 569–75. http://dx.doi.org/10.2478/s11532-009-0058-3.

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AbstractTwo novel norcantharidin acylamide acids (HL1=N-pyrimidine norcantharidin acylamide acid, C12H13N3O4; HL2=N-pyridine norcantharidin acylamide acid, C13H14N2O4) were synthesized by a reaction of norcantharidin(NCTD) with 2-aminopyrimidine and 2-aminopyridine, respectively. Their structures were characterized by elemental analysis, IR, UV and 1 H NMR. Fluorescence titration and viscosity measurements indicated that HL1, HL2 and HL3 (HL3=N-phenyl norcantharidin acylamide acid, C14H15NO4) can bind calf thymus DNA via partial intercalation. The liner Stern-Volmer quenching constant Ksv valu

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16

Yan, Jun, Xiaoyue Ji, Shugui Hua та Jing Wang. "Recent Advances of α-Aryl Vinyl Azides in Nitrogen Heterocycle Synthesis". Chinese Journal of Organic Chemistry 38, № 4 (2018): 791. http://dx.doi.org/10.6023/cjoc201709025.

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17

Karpagam, S., and S. Guhanathan. "Synthesis and Properties of Nitrogen Heterocycle-Functionalized Core-Shell Hyperbranched Polyester." International Polymer Processing 30, no. 2 (2015): 233–42. http://dx.doi.org/10.3139/217.2990.

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18

Chemler, Sherry R. "ChemInform Abstract: Stereoselective Nitrogen Heterocycle Synthesis Mediated by Chiral Metal Catalysts." ChemInform 43, no. 19 (2012): no. http://dx.doi.org/10.1002/chin.201219230.

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19

Gein, Vladimir L., and Evgenia V. Pastukhova. "Synthesis of 5-aryl-4-acyl-3-hydroxy- 1-carboxymethyl-3-pyrrolin-2-ones." Butlerov Communications 64, no. 11 (2020): 9–12. http://dx.doi.org/10.37952/roi-jbc-01/20-64-11-9.

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5-Aryl-1,4-disubstituted terahydropyrrole-2,3-diones are five-membered nitrogen heterocycles containing in the first alkyl position or an aryl functionalized substituent and in the fourth position in another state of nature an acyl residue. Trahydropyrrole-2,3-diones constitute a significant class of available and stable substances. Along with this, they easily enter into reactions with various nucleophilic reagents due to the highly reactive carbonyl group in the third position of the heterocycle. The presence of the latter, as well as the carbonyl group of the side chain, makes it possible t

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20

Roxburgh, Craig J., and Lee Banting. "Synthesis and Ring Cyclization - Expansion - Contraction Reactions of Some New 2,2-Disubstituted Indan-1,3-diones and Related Compounds." Australian Journal of Chemistry 59, no. 1 (2006): 59. http://dx.doi.org/10.1071/ch05169.

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We have found that the hydrochloride of 2-phenyl-2-[2-(2-piperidyl)ethyl]-4,5,6,7-tetrahydroindan-1,3-dione 1 possesses marked analgesic activity (100% inhibition referenced to codeine) and report, as part of an extensive synthetic program, the synthesis of 38 new and structurally related compounds. Selective catalytic hydrogenation of the pyridine ring of 2-phenyl-2-[2-(2-pyridyl)ethyl]-indan-1,3-dione 2 yields the nine-membered nitrogen-containing heterocycle 6 by a novel ring cyclization–expansion reaction. The structural and functional group parameters required for this novel ring-expansio

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21

RAO, K. A., J. N. GADRE, and S. PEDNEKAR. "ChemInform Abstract: Condensed Heterocycles. Part 1. Synthesis of Pyrazolo-, Isoxazolo-, Pyrimido-, Pyranopyridinones and a Novel Bridgehead Nitrogen Heterocycle." ChemInform 28, no. 41 (2010): no. http://dx.doi.org/10.1002/chin.199741181.

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22

Zheng, Yun-Man, Kai Wang, Tian Li, Xiu-Lan Zhang, and Zao-Yin Li. "Synthesis, Singlet Oxygen Photogeneration and DNA Photocleavage of Porphyrins with Nitrogen Heterocycle Tails." Molecules 16, no. 5 (2011): 3488–98. http://dx.doi.org/10.3390/molecules16053488.

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23

Nath, Jayanta, Dipjyoti Kalita, and Jubaraj B. Baruah. "Role of hydrogen peroxide in the synthesis of nitrogen heterocycle containing cobalt complexes." Polyhedron 30, no. 15 (2011): 2558–63. http://dx.doi.org/10.1016/j.poly.2011.07.010.

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24

Thielmann, T., M. Güntert, M. Köpsel, and P. Werkhoff. "Synthesis of 1H-pyrrolo-[1.2-c]-[1.3]-thiazine: A new sulphur-nitrogen heterocycle." Tetrahedron Letters 30, no. 34 (1989): 4507–8. http://dx.doi.org/10.1016/s0040-4039(01)80730-9.

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25

Guo, Can-Cheng, He-Ping Li, and Xiao-Bing Zhang. "Study on synthesis, characterization and biological activity of some new nitrogen heterocycle porphyrins." Bioorganic & Medicinal Chemistry 11, no. 8 (2003): 1745–51. http://dx.doi.org/10.1016/s0968-0896(03)00027-0.

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26

Heine, Andreas, Dietmar Fest, Dietmar Stalke, Carl D. Habben, Anton Meller, and George M. Sheldrick. "Synthesis and X-ray crystal structure of a tricyclic lead–nitrogen–boron heterocycle." J. Chem. Soc., Chem. Commun., no. 10 (1990): 742–43. http://dx.doi.org/10.1039/c39900000742.

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27

Gagné, Michel, and Brandon Moyer. "Taming Silylium Ions for Synthesis: N-Heterocycle Synthesis via Stereoselective C–C Bond Formation." Synlett 28, no. 18 (2017): 2429–34. http://dx.doi.org/10.1055/s-0036-1590967.

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Silylium ions (formally [R3Si]+) have long been the subject of investigations and significant debate in both theoretical and experimental chemistry, but few catalytic, synthetic applications have been reported due to the exceptionally high reactivity and Lewis acidity of these elusive species. Results to be discussed include the application of easily accessible silylium ion catalysts to the stereoselective synthesis of various N-heterocyclic pyrrolidine and piperidine scaffolds. The tested substrates are derived from the chiral pool and can be obtained in three high-yielding steps from amino a

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28

da S.M. Forezi, Luana, Mariana F. C. Cardoso, Daniel T. G. Gonzaga, Fernando de C. da Silva, and Vitor F. Ferreira. "Alternative Routes to the Click Method for the Synthesis of 1,2,3-Triazoles, an Important Heterocycle in Medicinal Chemistry." Current Topics in Medicinal Chemistry 18, no. 17 (2018): 1428–53. http://dx.doi.org/10.2174/1568026618666180821143902.

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Heterocyclic rings having nitrogen atoms are the molecular fragments most used in drug design by using the tools of medicinal chemistry. The 1,2,4-triazole rings are part of an extensive family of drugs that are in use in the pharmaceutical market. More recently, 1,2,3-triazole rings have begun to arouse the great interest of scientists and therefore, many researches have been developed seeking the synthesis of new substances and their possible biological activities. A number of articles have been published by us and others highlighting the synthetic and biological aspects of 1,2,3-triazoles.

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29

China, Hideyasu, Ravi Kumar, Kotaro Kikushima, and Toshifumi Dohi. "Halogen-Induced Controllable Cyclizations as Diverse Heterocycle Synthetic Strategy." Molecules 25, no. 24 (2020): 6007. http://dx.doi.org/10.3390/molecules25246007.

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In organic synthesis, due to their high electrophilicity and leaving group properties, halogens play pivotal roles in the activation and structural derivations of organic compounds. Recently, cyclizations induced by halogen groups that allow the production of diverse targets and the structural reorganization of organic molecules have attracted significant attention from synthetic chemists. Electrophilic halogen atoms activate unsaturated and saturated hydrocarbon moieties by generating halonium intermediates, followed by the attack of carbon-containing, nitrogen-containing, oxygen-containing,

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30

Foster, Radleigh A. A., and Michael C. Willis. "Tandem inverse-electron-demand hetero-/retro-Diels–Alder reactions for aromatic nitrogen heterocycle synthesis." Chem. Soc. Rev. 42, no. 1 (2013): 63–76. http://dx.doi.org/10.1039/c2cs35316d.

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31

Hu, Bao, and Stephen G. DiMagno. "ChemInform Abstract: Reactivities of Vinyl Azides and Their Recent Applications in Nitrogen Heterocycle Synthesis." ChemInform 46, no. 21 (2015): no. http://dx.doi.org/10.1002/chin.201521256.

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32

Wang, Jin-Jun, Chao Liu, Jin Wu, Ran-Ran Liu, and Peng Zhang. "Synthesis of Chlorins Fused with Nitrogen-Containing Heterocycle by the Modification along TheirN21-N23axis." Journal of Heterocyclic Chemistry 51, no. 2 (2013): 392–97. http://dx.doi.org/10.1002/jhet.1598.

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33

Eugene-Osoikhia (Nee Adebesin), Tunmise T., A. O. Aleem, and F. Ayeni. "SYNTHESIS, CHARACTERISATION AND ANTIMICROBIAL STUDIES OF MIXED LIGANDS METAL (II) COMPLEXES OF SULFAMETHOXAZOLE AND N,N- DONORS HETEROCYCLES." FUDMA JOURNAL OF SCIENCES 4, no. 2 (2020): 217–32. http://dx.doi.org/10.33003/fjs-2020-0402-179.

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Two mixed ligands of sulfamethoxazole (SMX) with N,N donor heterocycles: 1,10-phenanthroline (phen) and 2,2′-bipyridine (bipy) metal complexes having the composition [M(SMX)(phen)X].nH2O and [M(SMX)(bipy)X].nH2O (where M = Zn(II) , Co(II) , Fe (II), Mn (II),Cu(II) ; X = SO4/Cl2) have been synthesised and characterised by physicochemical methods based on their solubility , metal analysis, infrared and UV-Visible techniques. Infrared spectra data showed SMX as a bidentate ligand coordinating to the metals through the N atom of the sulfonamide group ((3195-3030cm-1) and oxygen atom of the sulfony

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34

Zhang, Wei, and Georgia Pugh. "Free radical reactions for heterocycle synthesis. Part 6: 2-Bromobenzoic acids as building blocks in the construction of nitrogen heterocycles." Tetrahedron 59, no. 17 (2003): 3009–18. http://dx.doi.org/10.1016/s0040-4020(03)00381-8.

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35

Tachrim, Zetryana Puteri, Lei Wang, Yuta Murai, and Makoto Hashimoto. "New Trends in Diaziridine Formation and Transformation (a Review)." Molecules 26, no. 15 (2021): 4496. http://dx.doi.org/10.3390/molecules26154496.

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This review focuses on diaziridine, a high strained three-membered heterocycle with two nitrogen atoms that plays an important role as one of the most important precursors of diazirine photoaffinity probes, as well as their formation and transformation. Recent research trends can be grouped into three categories, based on whether they have examined non-substituted, N-monosubstituted, or N,N-disubstituted diaziridines. The discussion expands on the conventional methods for recent applications, the current spread of studies, and the unconventional synthesis approaches arising over the last decad

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36

Hekmatshoar, Rahim, Sodeh Sadjadi, Samaheh Sadjadi, Majid M. Heravi, Yahya S. Beheshtiha, and Fatemeh F. Bamoharram. "New and General Nitrogen Heterocycle Synthesis: Use of Heteropoly Acids as a Heterogeneous Recyclable Catalyst." Synthetic Communications 40, no. 11 (2010): 1708–16. http://dx.doi.org/10.1080/00397910903161793.

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37

Yang, Daoshan, Baojuan An, Wei Wei, Laijin Tian, Ben Huang, and Hua Wang. "Copper-Catalyzed Domino Synthesis of Nitrogen Heterocycle-Fused Benzoimidazole and 1,2,4-Benzothiadiazine 1,1-Dioxide Derivatives." ACS Combinatorial Science 17, no. 2 (2015): 113–19. http://dx.doi.org/10.1021/co500125n.

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38

PODGORSKI, T. A., A. J. TOMLINSON, J. A. MLOTKIEWICZ, and I. A. S. LEWIS. "ChemInform Abstract: Synthesis of 2-(2-Hydroxyacetyl)pyrrole-1-acetic Acid: A New Nitrogen Heterocycle." ChemInform 23, no. 17 (2010): no. http://dx.doi.org/10.1002/chin.199217148.

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39

Hu, Xin, Yin-Ping Li, Yong-Jiang Wang, Wei-Jun Du, and Ji-Xi Guo. "Synthesis and Crystal Structures of Two Complexes with Carboxylic Derivatives of Nitrogen-containing Heterocycle Ligands." Journal of Chemical Crystallography 40, no. 10 (2010): 846–51. http://dx.doi.org/10.1007/s10870-010-9752-4.

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40

Carrascosa, H., C. González Díaz, G. M. Muñoz Caro, P. C. Gómez, and M. L. Sanz. "Synthesis of the first nitrogen-heterocycles in interstellar ice analogues containing methylamine (CH3NH2) exposed to UV radiation: formation of trimethylentriamine (TMT, c-(-CH2-NH)3) and hexamethylentetramine (HMT, (CH2)6N4)." Monthly Notices of the Royal Astronomical Society 506, no. 1 (2021): 791–805. http://dx.doi.org/10.1093/mnras/stab1710.

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ABSTRACT Hexamethylentetramine has drawn a lot of attention due to its potential to produce prebiotic species. This work aims to gain a better understanding in the chemical processes concerning methylamine under astrophysically relevant conditions. In particular, this work deeps into the formation of N-heterocycles in interstellar ice analogues exposed to UV radiation, which may lead to the formation of prebiotic species. Experimental simulations of interstellar ice analogues were carried out in ISAC. ISAC is an ultrahigh vacuum chamber equipped with a cryostat, where gas and vapour species ar

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41

Wang, Wenzhi, Lei Lei, Zhi Liu, Hongbo Wang, and Qingguo Meng. "Design, Synthesis, and Biological Evaluation of Novel Nitrogen Heterocycle-Containing Ursolic Acid Analogs as Antitumor Agents." Molecules 24, no. 5 (2019): 877. http://dx.doi.org/10.3390/molecules24050877.

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Nineteen ursolic acid analogues were designed, synthesized, and evaluated for their antiproliferative activity against the Hela and MKN45 cell lines. Some compounds containing a piperazine moiety displayed moderate to high levels of antitumor activities against the tested cancer cell lines. The most potent compound shares the IC50 value of 2.1 µM and 2.6 µM for the Hela and MKN45 cell lines, respectively. Further mechanism studies and in vivo antitumor studies have shown that it decreased the apoptosis regulator (BCL2/BAX) ratio, disrupted mitochondrial potential and induced apoptosis, and sup

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42

Feng, Xiu, Qin Wang, Jie Gao, Shu Ban, and Qing Li. "Synthesis of Novel Nitrogen-Containing Heterocycle Bromophenols and Their Interaction with Keap1 Protein by Molecular Docking." Molecules 22, no. 12 (2017): 2142. http://dx.doi.org/10.3390/molecules22122142.

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43

Foster, Radleigh A. A., and Michael C. Willis. "ChemInform Abstract: Tandem inverse-Electron-Demand hetero-/retro-Diels-Alder Reactions for Aromatic Nitrogen Heterocycle Synthesis." ChemInform 44, no. 18 (2013): no. http://dx.doi.org/10.1002/chin.201318240.

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44

Andreeva, Olga V., Bulat F. Garifullin, Vladimir V. Zarubaev, et al. "Synthesis and Antiviral Evaluation of Nucleoside Analogues Bearing One Pyrimidine Moiety and Two D-Ribofuranosyl Residues." Molecules 26, no. 12 (2021): 3678. http://dx.doi.org/10.3390/molecules26123678.

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A series of 1,2,3-triazolyl nucleoside analogues in which 1,2,3-triazol-4-yl-β-d-ribofuranosyl fragments are attached via polymethylene linkers to both nitrogen atoms of the heterocycle moiety (uracil, 6-methyluracil, thymine, quinazoline-2,4-dione, alloxazine) or to the C-5 and N-3 atoms of the 6-methyluracil moiety was synthesized. All compounds synthesized were evaluated for antiviral activity against influenza virus A/PR/8/34/(H1N1) and coxsackievirus B3. Antiviral assays revealed three compounds, 2i, 5i, 11c, which showed moderate activity against influenza virus A H1N1 with IC50 values o

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Eweas, Ahmad Farouk, Qasem Mahmoud Aref Abdallah, and Mohamed Fouad Elbadawy. "Synthesis and biological evaluation of some new 2-pyridylquinazoline derivatives." Current Chemistry Letters 10, no. 4 (2021): 459–70. http://dx.doi.org/10.5267/j.ccl.2021.4.005.

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2-pyridyl [3H]-quinazolin-4-one derivatives fused or substituted with different oxygen or nitrogen heterocycle moieties as potential anti-tumor and anti-microbial agents were prepared, characterized and biologically screened. The synthesis process started from 5-bromo-2-[pyridin-4-ylcarbonyl]amino]benzoic acid which was converted to the crucial building block 6-Bromo-2-(pyridin-4-yl)quinazolin-4(3H)-one via two alternative routes. Compound 3 underwent halogenation reaction POCl3 and PCl5 to afford compound 6-Bromo-4-chloro-2-(pyridin-4-yl)quinazoline 4. The novel cyclized products 5a,b-10 were

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Oakley, Richard T. "1993 ALCAN Award Lecture Chemical binding within and between inorganic rings; the design and synthesis of molecular conductors." Canadian Journal of Chemistry 71, no. 11 (1993): 1775–84. http://dx.doi.org/10.1139/v93-220.

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For a given number of skeletal atoms, the π-electron count of an unsaturated heterocycle can be modified by the incorporation of heteroatoms from different periodic groups. Sulfur and nitrogen are particularly effective in this regard, as their high electronegativity can stabilize electron-rich π-systems. A variety of aromatic, anti-aromatic, and radical systems can be prepared from admixtures of these elements. While the properties of these ring systems are interesting in their own right, the compounds are not without relevance in the design of new materials. The strong interannular interacti

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Hekmatshoar, Rahim, Sodeh Sadjadi, Samaheh Sadjadi, Majid M. Heravi, Yahya S. Beheshtiha, and Fatemeh F. Bamoharram. "ChemInform Abstract: New and General Nitrogen Heterocycle Synthesis: Use of Heteropoly Acids as a Heterogeneous Recyclable Catalyst." ChemInform 41, no. 46 (2010): no. http://dx.doi.org/10.1002/chin.201046031.

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Heynderickx, Arnault, Sébastien Nénon, Olivier Siri, Vladimir Lokshin, and Vladimir Khodorkovsky. "1,2,3,4-Tetrahydro-1,4,5,8-tetraazaanthracene revisited: properties and structural evidence of aromaticity loss." Beilstein Journal of Organic Chemistry 15 (August 28, 2019): 2059–68. http://dx.doi.org/10.3762/bjoc.15.203.

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The synthesis and properties of 1,2,3,4-tetrahydro-1,4,5,8-tetraazaanthracene (THTAA) – a heterocycle involving both >N–H donating and =N– accepting moieties – have been reinvestigated. Unlike previously reported, THTAA is a thermally stable compound that can be re-sublimed at 300–310 °C without decomposition. Controlled introduction of substituents at the nitrogen atoms of THTAA led to variation of its electron donor/acceptor capability that allowed fine-tuning the absorption properties. The propensity of these compounds and a number of its derivatives to form infinite chains involving &gt

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Müller-Buschbaum, Klaus. "3D-[Pr(Im)3(ImH)]@ImH: Ein dreidimensionales Netzwerk mit vollständiger Stickstoffkoordination aus einer Imidazolschmelze / 3D-[Pr(Im)3(ImH)]@ImH: A Three-Dimensional Network with Complete Nitrogen Coordination Obtained from an Imidazole Melt." Zeitschrift für Naturforschung B 61, no. 7 (2006): 792–98. http://dx.doi.org/10.1515/znb-2006-0704.

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The reaction of a melt of unsubstituted imidazole with praseodymium metal yields bright green crystals of 3D-[Pr(Im)3(ImH)]@ImH. Imidazolate ligands coordinate η1 via both N atoms their 1,3 positioning within the heterocycle being responsible for the connection of praseodymium atoms. A 3-dimensional network is formed with imidazole molecules from the melt intercalated in the crystal structure. The imidazole molecules can be released and temperature dependent reversibly be exchanged with gas molecules including argon. Thus the solvent free high temperature synthesis of rare earth elements with

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Barclay, Tosha M., Robin G. Hicks, Andrew S. Ichimura, and Greg W. Patenaude. "Synthesis and characterization of a spirocyclic phosphaverdazyl radical - cyclophosphazene hybrid: Evidence for spin transfer from a verdazyl radical to a phosphazene ring." Canadian Journal of Chemistry 80, no. 11 (2002): 1501–6. http://dx.doi.org/10.1139/v02-090.

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The synthesis and characterization of a new 6-phosphaverdazyl radical incorporated into a spirocyclic framework containing a cyclotriphosphazene ring is described. Reaction of 1,1,3,3-bis[spiro-2',2''-dioxy-1',1''-biphenyl]-5,5-bis(1-methylhydrazido)-1,3,5,2,4,6-cyclotriphosphazene (7) with trimethylorthobenzoate yielded 6-[2,2,4,4-bis(2,2'-dioxy-1,1'-biphenyl)-2,4,6,1,3,5-cyclotriphosphazen-6-yl]-1,2,5,6-tetrahydro-1,5-dimethyl-3-phenyl-1,2,4,5,6-tetrazaphosphorine (8), which was characterized spectroscopically and by X-ray diffraction. Oxidation of 8 yielded 6-[2,2,4,4-bis(2,2'-dioxy-1,1'-bi

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