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Relevant bibliographies by topics / Nitrogen heterocycles

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Academic literature on the topic 'Nitrogen heterocycles'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 May 2024

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Journal articles on the topic "Nitrogen heterocycles"

1

Zhu, Yannan, and You Huang. "Organocatalyzed [3+3] Annulations for the Construction of Heterocycles." Synthesis 52, no. 08 (2020): 1181–202. http://dx.doi.org/10.1055/s-0039-1690810.

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Six-membered heterocyclic systems are widely distributed in many natural products and pharmaceuticals, and the construction of highly functionalized six-membered heterocyclic compounds is an important topic in modern organic synthesis. Organocatalyzed [3+3] annulations represents an important method for assembling a substantial variety of six-membered cycles that contain one or more heteroatoms. This review describes the development of organocatalyzed [3+3] annulations for the synthesis of six-membered heterocycles, including organocatalysis using secondary amines, tertiary amines, phosphines,

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Egbujor, Melford C., Paolo Tucci, Ugomma C. Onyeije, Chigbundu N. Emeruwa, and Luciano Saso. "NRF2 Activation by Nitrogen Heterocycles: A Review." Molecules 28, no. 6 (2023): 2751. http://dx.doi.org/10.3390/molecules28062751.

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Several nitrogen heterocyclic analogues have been applied to clinical practice, and about 75% of drugs approved by the FDA contain at least a heterocyclic moiety. Thus, nitrogen heterocycles are beneficial scaffolds that occupy a central position in the development of new drugs. The fact that certain nitrogen heterocyclic compounds significantly activate the NRF2/ARE signaling pathway and upregulate the expression of NRF2-dependent genes, especially HO-1 and NQO1, underscores the need to study the roles and pharmacological effects of N-based heterocyclic moieties in NRF2 activation. Furthermor

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Kerru, Nagaraju, Lalitha Gummidi, Suresh Maddila, Kranthi Kumar Gangu, and Sreekantha B. Jonnalagadda. "A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications." Molecules 25, no. 8 (2020): 1909. http://dx.doi.org/10.3390/molecules25081909.

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The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing heterocyclic moieties. In the forthcoming decade, a much greater share of new nitrogen-based pharmaceuticals is anticipated. Many new nitrogen-based heterocycles have been designed. The number of novel N-heterocyclic moieties with significant physiological properties and promising applications in medicinal chemistry is ever-growing. In this review, we co

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4

Zhang, Ming, Qiuhong Wang, Yiyuan Peng, et al. "Transition metal-catalyzed sp3 C–H activation and intramolecular C–N coupling to construct nitrogen heterocyclic scaffolds." Chemical Communications 55, no. 87 (2019): 13048–65. http://dx.doi.org/10.1039/c9cc06609h.

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Kumar, Adarsh, Ankit Kumar Singh, Harshwardhan Singh, et al. "Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective." Pharmaceuticals 16, no. 2 (2023): 299. http://dx.doi.org/10.3390/ph16020299.

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Cancer is one of the major healthcare challenges across the globe. Several anticancer drugs are available on the market but they either lack specificity or have poor safety, severe side effects, and suffer from resistance. So, there is a dire need to develop safer and target-specific anticancer drugs. More than 85% of all physiologically active pharmaceuticals are heterocycles or contain at least one heteroatom. Nitrogen heterocycles constituting the most common heterocyclic framework. In this study, we have compiled the FDA approved heterocyclic drugs with nitrogen atoms and their pharmacolog

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Dudhe, Anshu R., Sachinkumar D. Gunjal, Sampath AG, Sushama Rawat, and YY Nandurkar. "An Overview on Nitrogen-containing Heterocyclic Compounds as Anticancer Agents." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 04 (2023): 1296–301. http://dx.doi.org/10.25258/ijpqa.14.4.72.

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Cancer accounts for nearly 10 million losses each year. Among the most prevalent cancer types are breast, lung, colon, rectum, and prostate cancers. Astonishingly, around one-third of cancer-related deaths can be attributed to factors such as tobacco usage, a high body mass index (BMI), alcohol consumption, restricted ingestion of fruits and vegetables, and inadequate bodily bustle. In the field of pharmaceuticals, heteroatoms and heterocyclic compounds frequently assume crucial roles and serve as common structural components in numerous active natural products. Statistically, the majority of

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Groso, Emilia, and Corinna Schindler. "Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles." Synthesis 51, no. 05 (2019): 1100–1114. http://dx.doi.org/10.1055/s-0037-1611651.

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This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.1 Introduction2 Expansion of Ring-Closing Metathesis Methods3 Evaluation of Catalyst Design4 Indenylidene Catalysts5 Unsymmetrical N-Heterocyclic Carbene Ligands6 Carbonyl-Olefin Metathesis7 Conclusions

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8

Rusu, Aura, Ioana-Maria Moga, Livia Uncu, and Gabriel Hancu. "The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy." Pharmaceutics 15, no. 11 (2023): 2554. http://dx.doi.org/10.3390/pharmaceutics15112554.

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Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial drug. These properties can affect the drug’s activity spectrum, potency, and pharmacokinetic and toxicological properties. Using scientific databases, we identified and discussed the antibacterials used in therapy, containing five-membered heterocycles in their molecular structure. The identified five-membered heterocycles used in antibacterial design contai

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9

Xia, Xiao-Feng, та Yan-Ning Niu. "Recent developments in the synthesis of nitrogen-containing heterocycles from β-aminovinyl esters/ketones as CC–N donors". Organic & Biomolecular Chemistry 20, № 2 (2022): 282–95. http://dx.doi.org/10.1039/d1ob01998h.

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Shaikh, Ansar R., Mazahar Farooqui, R. H. Satpute, and Syed Abed. "Overview on Nitrogen containing compounds and their assessment based on ‘International Regulatory Standards’." Journal of Drug Delivery and Therapeutics 8, no. 6-s (2018): 424–28. http://dx.doi.org/10.22270/jddt.v8i6-s.2156.

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Heterocyclic compounds have a role in most fields of sciences such as medicinal chemistry, biochemistry also another area of sciences. More than 90% of new drugscontain heterocycles and the interface between chemistry and biology, at which so much new scientific insight, discovery and application is taking place is crossed by heterocyclic compounds. Compounds derived from heterocyclic rings in pharmacy, medicine, agriculture, plastic, polymer and other fields.Most active heterocycles that have shown considerable biological actions as antifungal, anti-inflammatory, antibacterial, anticonvulsant

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Dissertations / Theses on the topic "Nitrogen heterocycles"

1

Hemmings, Philippa Rachel. "Nitrogen heterocycles from sugars." Thesis, University of Oxford, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314823.

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Slater, Jonathan. "Cyclometallated nitrogen heterocycles - metallomesogens." Thesis, University of Warwick, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269196.

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3

Treacy, Alan Bernard. "Nitrogen heterocycles in asymmetric synthesis." Thesis, Queen's University Belfast, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361310.

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Jones, A. D. "Novel syntheses of nitrogen heterocycles." Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.388287.

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5

McGuigan, H. "Synthetic studies on nitrogen heterocycles." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375469.

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6

Burnett, Duane Arthur. "Synthesis of nitrogen containing heterocycles /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487264603219377.

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Austin, Carolyn A. "Diversity-Based Synthesis of Nitrogen Heterocycles." Thesis, University of Glasgow, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484942.

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Brief investigations were carried out towards the synthesis of 2,4-disubstituted quinolines and 2,6-disubstituted piperidines using titanium alkylidene chemistry, but these were unsuccessful. A route towards the diversity based stereoselective synthesis of 2-substituted azepane derivatives was explored via titanium alkylidene chemistry. Thioacetals i were reacted with low valent titanium(II) species ii to produce titanium(IV) alkylidenes that were reacted with resin-bound esters iii. Cleavage of the resulting enol ethers led to a small library of amino ketones iv, but reductive amination to gi

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Jones, Matthew Lloyd. "Radical rearrangements of nitrogen-containing heterocycles." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289342.

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Anwar, Muhammad. "Synthesis of highly functionalised nitrogen heterocycles." Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.441057.

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Coates, Brian. "The stereoselective synthesis of nitrogen heterocycles." Thesis, Queen's University Belfast, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.334524.

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Books on the topic "Nitrogen heterocycles"

1

Asymmetric synthesis of nitrogen heterocycles. Wiley-VCH, 2009.

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2

Wongtap, Hathaichanuk. A radical approach to nitrogen heterocycles. typescript, 1999.

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3

Parshikov, Igor A. Microbial Transformation of Nitrogen Containing Heterocycles. Primedia E-launch LLC, 2016.

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4

El Ashry, El Sayed H., and Ahmed El Nemr, eds. Synthesis of Naturally Occurring Nitrogen Heterocycles from Carbohydrates. Blackwell Publishing Ltd, 2005. http://dx.doi.org/10.1002/9780470988619.

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5

Filik, Robert Paul. Synthesis of nitrogen containing heterocycles via radical cyclisation. typescript, 2000.

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6

1962-, El-Nemr Ahmed, ed. Synthesis of naturally occurring nitrogen heterocycles from carbohydrates. Blackwell Pub., 2005.

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7

Hatton, Kevin Brian. Studies on the synthesis of nitrogen and oxygen heterocycles. University of East Anglia, 1986.

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8

Vicario, Jose L., Dolores Badia, and Luisa Carrillo. New methods for the asymmetric synthesis of nitrogen heterocycles 2005. Research Signpost, 2005.

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9

Rees, Anthony John. The synthesis and reactions of some fluorinated nitrogen-containing heterocycles. University of Birmingham, 1996.

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10

Ring nitrogen and key biomolecules: The biochemistry of N-heterocycles. Kluwer Academic, 1998.

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Book chapters on the topic "Nitrogen heterocycles"

1

Rowlands, C. C., and R. D. Farley. "15.3.2 Nitrogen containing heterocycles." In Landolt-Börnstein - Group II Molecules and Radicals. Springer Berlin Heidelberg, 2008. http://dx.doi.org/10.1007/978-3-540-45824-1_40.

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2

Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Fused Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_6.

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3

Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Three-Membered Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_1.

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Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Four-Membered Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_2.

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Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Five-Membered Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_3.

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6

Haas, Alois, Dieter Koschel, and Ulrich Niemann. "Six-Membered Perfluorohalogenoorgano Nitrogen Heterocycles." In F Perfluorohalogenoorgano Compounds of Main Group Elements. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-662-07759-7_4.

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7

Assad, Humira, Suresh Kumar, and Ashish Kumar. "Nitrogen, Sulfur, and Nitrogen-based Heterocycles Corrosion Inhibitors." In Handbook of Heterocyclic Corrosion Inhibitors. CRC Press, 2023. http://dx.doi.org/10.1201/9781003377016-11.

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8

Brown, E. G. "N-Heterocycles and living systems — conclusions." In Ring Nitrogen and Key Biomolecules. Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4906-8_10.

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9

Joule, J. A., K. Mills, and G. F. Smith. "Heterocycles containing a ring-junction nitrogen." In Heterocyclic Chemistry. Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-3222-8_24.

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10

Vaquero, Juan J., and Julio Alvarez-Builla. "Heterocycles Containing a Ring-Junction Nitrogen." In Modern Heterocyclic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527637737.ch22.

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Conference papers on the topic "Nitrogen heterocycles"

1

Mangalagiu, Violeta, Dumitrela Diaconu, Costel Moldoveanu, et al. "Hybrid and chimeric nitrogen heterocycles with biological activity." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab01.

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Nitrogen heterocycles, especially azine and azole derivatives, are highly valuable scaffolds in medicinal chemistry, being the core components of a large variety of drugs with variously biological activity such as antiplasmodial and antimalarial, antitubercular, antibacterial, antifungal, anticancer, analgesic, antidepressant, anxiolytics, antihypertensive, anticoagulants, diuretics, etc. As a result, obtaining of such entities continues to arouse a strong interest from academia and industry. As part of our ongoing research in the area of nitrogen heterocyclic derivatives, we present herein so

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2

Gutierrez, Margarita, Yorley Duarte, Barbara Arevalo, et al. "NITROGEN HETEROCYCLES AS POTENTIAL ANTIBACTERIAL AGENTS." In The 17th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2013. http://dx.doi.org/10.3390/ecsoc-17-a035.

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3

Tabolin, Andrey, Vladimir Motornov, Valentine Nenajdenko та Sema Ioffeа. "α-FLUORONITROALKENES IN THE SYNTHESIS OF FLUORINATED HETEROCYCLES". У Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m735.aks-2019/123-125.

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4

Efimova, Tatyana, Olga Ozerova, Maria Ivanova, and Tamara Novikova. "1-AMINO-2-NITROGUANIDINE IN THE SYNTHESIS OF NITROGEN HETEROCYCLES." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m733.aks-2019/112-118.

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5

Voinkov, E., E. Ulomsky, and V. Rusinova. "STABLE NITROACETONITRILE POTASSIUM SALT IN SYNTHESIS OF NITROGEN-CONTAINING HETEROCYCLES." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m784.aks-2019/319-321.

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6

Silva, Gabriela D. da, Piero Bagnaresi, and Rodrigo L. O. R. Cunha. "Organoselenium functionalized nitrogen heterocycles: a proposition for new antimalarials." In 15th Brazilian Meeting on Organic Synthesis. Editora Edgard Blücher, 2013. http://dx.doi.org/10.5151/chempro-15bmos-bmos2013_20131014142313.

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Savateev, Konstantin, Evgeny Ulomsky, and Vladimir Rusinova. "CHLORODEOXYGENATION OF NITROAZOLOPYRIMIDINES AS A PROMISING METHOD FOR SYNTHESIS OF HETEROCYCLES WITH USEFUL BIOLOGICAL ACTIVITY." In Chemistry of nitro compounds and related nitrogen-oxygen systems. LLC MAKS Press, 2019. http://dx.doi.org/10.29003/m734.aks-2019/119-122.

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Deng, Suwen, Xingye Zeng, Wei Hu, and Xiaoping Liu. "DFT-based QSAR Study of Copper (II) Complexes with Quinolones and Nitrogen-donor Heterocycles." In 2012 International Conference on Biomedical Engineering and Biotechnology (iCBEB). IEEE, 2012. http://dx.doi.org/10.1109/icbeb.2012.142.

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Stevanović, Nevena Lj, Mia Stanković, Tina P. Andrejević, Darko P. Ašanin, Ivana M. Stanojević, and Biljana Đ. Glišić. "DNA AND BSA INTERACTIONS OF COPPER(II) AND ZINC(II) COMPLEXES WITH ANTIFUNGAL AGENT FLUCONAZOLE." In 1st INTERNATIONAL Conference on Chemo and BioInformatics. Institute for Information Technologies, University of Kragujevac, 2021. http://dx.doi.org/10.46793/iccbi21.399s.

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Aromatic nitrogen-containing heterocycles (N-heterocycles) have attracted a considerable attention as scaffolds for compounds, which have an application in different pharmacological areas, ranging from vitamins to different antimicrobial and antitumor agents. In this respect, azoles are of special importance as potent and broad-spectrum agents used for the treatment of many invasive fungal infections. In the present study, the interaction of the clinically used antifungal drug fluconazole (fcz) and its copper(II) and zinc(II) complexes, {[CuCl2(fcz)2].5H2O}n (1) and {[ZnCl2(fcz)2]·2C2H5OH}n (2

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Birca, Natalia, and Veaceslav Kulcitki. "Late stage functionalization of cyclic terpenoids by atom transfer radical addition. A convenient route towards nitrogen heterocycles." In Scientific seminar with international participation "New frontiers in natural product chemistry". Institute of Chemistry, Republic of Moldova, 2023. http://dx.doi.org/10.19261/nfnpc.2023.ab12.

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Terpens are a class of widely spread natural compounds with a broad range of biological properties, showing ‘drug-like’ chemical properties, including lipophilicity, interesting molecular geometry, alkylating center reactivity etc [1]. Nevertheless, nitrogen-containing terpens, which can show diverse functionality and biological activity in living cells, are rare in natural sources. We present in this communication the atom transfer radical additions performed on relevant terpene derivatives of labdane and drimane framework, compounds 1-3, and resulting in a series of azido-compounds. Carboazi

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Reports on the topic "Nitrogen heterocycles"

1

Lineberger, William C., and Veronica M. Bierbaum. Thermochemistry and Dynamics of Reactive Species: Nitrogen-Rich Substituted Heterocycles and Anionic Components of Ionic Liquids. Defense Technical Information Center, 2009. http://dx.doi.org/10.21236/ada495370.

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Parshikov, Igor. Microbial Transformation of Some Ethylpyridines by Fungi. Intellectual Archive, 2022. http://dx.doi.org/10.32370/iaj.2635.

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We were observed transformation 4-ethylpyridine and 2-methyl-5-ethylpyridine by fungus Beauveria bassiana ATCC 7159. Stereoselective oxidation of methylene group leading to the optically active (-)-(1-hydroxyethyl)pyridine was shown. Besides, the hydroxylation of methyl groups and the oxidation of the heterocyclic ring in the nitrogen atom to the respective primary alcohols and N-oxides were observed

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