Academic literature on the topic 'Nitrostyrene'

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Journal articles on the topic "Nitrostyrene"

1

Safaei, Elham, Sara Sobhani, and Nasrin Razavi. "Efficient synthesis of 2-indolyl-1-nitroalkanes catalyzed by tetramethyl-tetra-3,4-pyridinoporphyrazinato copper(II) methyl sulfate." Journal of Porphyrins and Phthalocyanines 16, no. 02 (2012): 227–34. http://dx.doi.org/10.1142/s1088424612004549.

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A new method for the synthesis of 2-indolyl-1-nitroalkanes from indoles and β-nitrostyrene via Michael addition catalyzed by [ Cu (3,4-tmtppa)] (MeSO4)4 as a reusable catalyst under solvent-free conditions is described. This method has been also successfully applied for Michael addition of 3-methyl-1-phenyl-5-pyrazolone with β-nitrostyrenes.
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2

Itoh, Kuniaki, Shigehisa Kishimoto та Kazuo Sagi. "Novel formation of isoxazoline N-oxide in addition to Michael adduct from the reaction of β-nitrostyrenes with 2-methoxyfuran — Experimental and theoretical studies". Canadian Journal of Chemistry 87, № 6 (2009): 760–74. http://dx.doi.org/10.1139/v09-068.

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2-Methoxyfuran reacts with β-nitrostyrenes to give Michael adducts. Interestingly, isoxazoline N-oxides were obtained in the reactions with β-nitrostyrenes possessing additional electron-withdrawing groups [COPh (2f) and CO2Et (2g)]. (Z)-Nitrostyrene (2g) gives trans-isoxazoline (4g) and (E)-nitrostyrene (2f) leads to the cis-form product 4f. We have used theoretical methods to investigate the mechanism and to probe the regio- and stereo-selectivity observed in the rearrangement and the Michael reactions. To account for the selectivity observed in these reactions, we examined the Fukui functio
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3

Komala, Ismiarni, Supandia, Nurhasnib та ін. "Microwave Assisted Synthesis of p-Methoxycinnamamides and p-Methoxy-β-nitrostyrenes from Ethyl p-methoxycinnamate and Screening their Anti-inflammatory Activity". Natural Product Communications 12, № 8 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200830.

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A new modification reaction of ethyl p-methoxycinnamate (1) to afford a series of p-methoxycinnamamide and p-methoxy-β-nitrostyrene has been developed by using the assistance of the unmodified microwave oven. The synthesized compounds were characterized by using various spectroscopic techniques and furthermore screened for their anti-inflammatory activity by using anti-denaturation of heat bovine serum albumin (BSA) method. The result of bioassay indicated that p-methoxycinnamamide derivatives and p-methoxy-β-nitrostyrenes showed interesting anti-inflammatory activity.
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4

Wang, Yen-Yun, Pei-Wen Hsieh, Yuk-Kwan Chen, et al. "CYT-Rx20 Inhibits Cervical Cancer Cell Growth and Migration Through Oxidative Stress-Induced DNA Damage, Cell Apoptosis, and Epithelial-to-Mesenchymal Transition Inhibition." International Journal of Gynecologic Cancer 27, no. 7 (2017): 1306–17. http://dx.doi.org/10.1097/igc.0000000000001033.

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ObjectiveThe β-nitrostyrene family has been reported to possess anticancer properties. However, the anticancer activity of β-nitrostyrenes on cervical cancer cells and the underlying mechanisms involved remain unexplored. In this study, a β-nitrostyrene derivative CYT-Rx20 (3′-hydroxy-4′-methoxy-β-methyl-β-nitrostyrene) was synthesized, and its anticancer activity on cervical cancer cells and the mechanisms involved were investigated.MethodsThe effect of CYT-Rx20 on human cervical cancer cell growth was evaluated using cell viability assay. Reactive oxygen species (ROS) generation and annexin
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5

Pomarański, Piotr, and Zbigniew Czarnocki. "l-Prolinal Dithioacetal: A Highly Effective Organocatalyst for the Direct Nitro-Michael Addition to Selected Cyclic and Aromatic Ketones." Synthesis 51, no. 17 (2019): 3356–68. http://dx.doi.org/10.1055/s-0037-1611531.

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The synthesis of novel l-prolinal dithioacetal and its application as an organocatalyst for the direct Michael addition of cyclic ketones and acetophenone derivatives to trans-β-nitrostyrene and related compounds is described. The prolinal dithioacetal acts as effective catalyst in the case of cyclic ketones of different ring size, in particular five- and six-membered examples, as well as larger and smaller ring systems. High enantioselectivity and diastereoselectivity is observed for different substrates and trans-β-nitrostyrenes. Also, the first asymmetric syntheses of selected 2-methyl-4-ni
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6

Alfarisi, Salman, Mardi Santoso, Alfinda Novi Kristanti, Imam Siswanto та Ni Nyoman Tri Puspaningsih. "Synthesis, Antimicrobial Study, and Molecular Docking Simulation of 3,4-Dimethoxy-β-Nitrostyrene Derivatives as Candidate PTP1B Inhibitor". Scientia Pharmaceutica 88, № 3 (2020): 37. http://dx.doi.org/10.3390/scipharm88030037.

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A derivative series of 3,4-dimethoxy-β-nitrostyrene was synthesized through nitroaldol reaction, including a new compound of 3,4-ethylenedioxy-β-bromo-β-nitrostyrene. The antimicrobial activity effect of 3,4-alkyloxy modification of β-nitrostyrene was investigated. A molecular docking study was also performed to obtain information about their interactions with protein tyrosine phosphatase 1B (PTP1B). The active residues of cysteine-215 and arginine-221 of PTP1B play a key role in signaling pathways that regulate various microorganism cell functions. It also acts as a negative regulator in sign
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7

Lazic, Jelena, Jelena Spasic, Djordje Francuski, et al. "Importance of the N-terminal proline for the promiscuous activity of 4-oxalocrotonate tautomerase (4-OT)." Journal of the Serbian Chemical Society 81, no. 8 (2016): 871–81. http://dx.doi.org/10.2298/jsc160222053l.

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Michael addition of aldehydes to nitroolefins is an effective method to obtain useful chiral ?-nitroaldehydes. ?-Nitroaldehydes are precursors for chiral ?-aminobytiric acid analogues which have numerous pharmacological activities and are used for treatment of neurological disorders. A whole-cell system based on recombinantly expressed 4-oxalocrotonate tautomerase (4-OT) has been developed and shown to be an effective biocatalyst for Michael addition of branched aldehydes to ?-nitrostyrenes. The aim of this study was to investigate the influence of the substitution of the N-terminal proline wi
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8

Shultsev, A. L. "Preparation of 4-nitrostyrene." Russian Journal of General Chemistry 83, no. 10 (2013): 1859–63. http://dx.doi.org/10.1134/s1070363213100101.

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9

Pavlovica, S., A. Gaidule та A. Zicmanis. "Synthesis of Β-Nitrostyrene in Highly Hydrophilic Ionic Liquid Media". Latvian Journal of Chemistry 52, № 1-2 (2014): 49–53. http://dx.doi.org/10.2478/ljc-2013-0005.

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Abstract The condensation reaction of benzaldehyde with nitromethane that resulted in the formation of β-nitrostyrene was studied in ionic liquid media - (2-hydroxyethyl)ammonium carboxylates (formates, lactates, acetates) without application of any other catalyst. The dependence of product yield on the ionic liquid cation and anion structure, the polarity of the ionic liquid and the pseudo-pH value of the reaction medium was investigated. The highest yield of the condensation reaction product - β-nitrostyrene was achieved in (2-hydroxyethyl) ammonium formate medium
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10

Clavijo, R. E., R. Araya-Maturana, B. K. Cassels, and B. Weiss-López. "Infrared spectra of nitrostyrene derivatives." Spectrochimica Acta Part A: Molecular Spectroscopy 50, no. 12 (1994): 2105–15. http://dx.doi.org/10.1016/0584-8539(94)80105-3.

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