Journal articles: 'Nitrous and Lipoproteins parameters'

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Struk, Zoryana D., Oksana I. Mel'nyk, Walery Zukow, and Igor L. Popovych. "Metabolic predictors of individual immune responses to adaptogenic balneotherapy." Journal of Education, Health and Sport 10, no. 2 (2020): 223–30. https://doi.org/10.5281/zenodo.3746282.

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Struk Zoryana D., Mel’nyk Oksana I., Zukow Walery, Popovych Igor L. Metabolic predictors of individual immune responses to adaptogenic balneotherapy. Journal of Education, Health and Sport. 2020;10(2):223-230. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.02.027 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.02.027 https://zenodo.org/record/3746282           The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.  The authors declare that there is no conflict of interests regarding the publication of this paper.   Received: 05.02.2020. Revised: 25.02.2020. Accepted: 28.02.2020.                 METABOLIC PREDICTORS OF INDIVIDUAL IMMUNE RESPONSES TO ADAPTOGENIC BALNEOTHERAPY   Zoryana D. Struk1, Oksana I. Mel’nyk2, Walery Zukow3, Igor L. Popovych1,4   1Ukrainian Scientific Research Institute of Medicine for Transport, Odesa, Ukraine medtrans2@ukr.net 2Danylo Halyts’kyǐ National Medical University, L’viv, Ukraine omelnyk7@gmail.com https://orcid.org/0000-0001-7928-4760 3Nicolaus Copernicus University, Torun, Poland w.zukow@wp.pl https://orcid.org/0000-0002-7675-6117 4OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine i.popovych@biph.kiev.ua https://orcid.org/0000-0002-5664-5591         Summary Background. Earlier four variants of the immune responses to adaptogenic balneotherapy have been identified. All four variants of immune responses are virtually unmistakably (with an accuracy of 97,7%) predicted by a set of 20 predictors including 12 immune blood parameters and one saliva parameter, 4 information parameters, 2 fecal microbiota parameters as well as erythrocyturia. In the next study discriminant analysis revealed that constellation 8 HRV and 5 Endocrine parameters as well as Gender of the patient predicts the nature of the immune response with an accuracy of 90,9%. The purpose of this study is to search for predictors of immune responses among the registered Metabolic parameters. Material and methods. The object of observation were 34 men and 10 women aged 24-70 years old, who came to the Truskavets’ spa for the treatment of chronic pyelonephritis combined with cholecystitis in remission. We determined them the Electrokinetic index, Lipoproteines spectrum, plasma and daily urine levels of Electrolytes and Nitrous metabolites as well as basal and postprandial volume of gall-bladder. Results. Discriminant analysis revealed 16 parameters as the predictors. Of these, 3 reflect the level of Plasma Electrolytes, 5 - the Urine Electrolytes, another 2 - the levels of plasma and urine Urea. Other predictors were: Very Low Density Lipoprotein Cholesterol plasma level, Body Mass index, fasting gallbladder volume and 30 minutes after cholekinetics, Electrokinetic index, and patient Age. These predictors, taken together, determine the nature of the immune response with an accuracy of 95,5%. Conclusion. The variety of immune responses to adaptogenic balneotherapy is quite strictly conditioned by the initial state of the neuroendocrine-immune complex, microbiota, cholekinetics and metabolism, as well as the age and sex of patients.   Key words: Electrolytes; Nitrous and Lipoproteins parameters; Cholekinetics; Immunity.

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Marazziti, D., R. Gurrieri, and F. Mucci. "Vitamin D, vitamin B12, folate, homocysteine, and major haemato-chemical parameters in patients with mood disorders." European Psychiatry 67, S1 (2024): S673. http://dx.doi.org/10.1192/j.eurpsy.2024.1399.

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IntroductionThe potential involvement of the immune and inflammatory systems has been extensively studied in mood disorders (MDs). Despite these findings and despite the fact that the pathogenetic role of altered immunologic and metabolic profiles in MDs is being confirmed in many current studies, there is still a lack of consensus about it, due to controversial results.ObjectivesThe present study aimed to appraise peripheral metabolic parameters (blood glucose, lipoproteins, triglycerides, uric acid, blood urea nitroge [BUN], transaminases and others9 and plasma/serum levels of essential nutrients (vitamin D, B12, folate and homocysteine) in a group of inpatients affected by MDs, as compared with healthy controls.MethodsMethods. Ten ml of venous blood was drawn from fasting subjects. The metabolic parameters and vitamins were measured according to common clinical-chemistry methods.Comparisons for continuous variables were performed by the Student’s t-test for variables that follow a normal distribution, and by the Wilcoxon-Mann-Whitney test for variables not normally distributed. The correlations between biological markers were explored by calculating the Pearson’s correlation coefficient or Spearman rank correlation.Results Most patients showed loer circulating vitamin D levels, in respect to both control subjects (P< .0001) and the normative cut-off values. This finding was paralleled by increased serum homocysteine concentrations i (P<.0001), indicating an imbalance in their methionine metabolism. Homocysteine levels were negatively correlated with vitamin D, vitamin B12 and folate in control subjects, but not in patients. In addition, patients displayed higher blood glucose and lower BUN than controls, indicating an impaired protein-to-carbohydrate metabolism and/or altered nutritional/dietary status.ConclusionsWe provide herein further support to the notion that MD patients are a population where vitamin deficits, dysmetabolism and/or dietary defects are common feature, and, s such, they might be more vulnerable to a variety of somatic illnesses than the general population. This cross-sectional investigation, albeit preliminary, might contribute to improve the characterization and the monitoring of the clinical status of mood disorder patients, as well as to identify new molecular targets for more tailored treatments ad of more pointed health-care intervention,Disclosure of InterestNone Declared

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Olugbenga, Olufunke T., and Joy E. . Okpuzor. "Vernonia amygdalina Extract Reverts Hematological and Biochemical Alterations in Rats Exposed to N-Nitroso-N-Ethyl Urea." African Scientist 24, no. 2 (2023): 183–88. http://dx.doi.org/10.26538/africanscientist.24.2.20230605.

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Environmental carcinogens or exogenous carcinogens includes chemical, biological, and physical agents that have the potential to increase cancer risk because of prolonged high prevalence of exposure. Exposure can be through the respiratory, digestive, cutaneous or other possible contamination routes. N-Nitroso-N-ethyl urea (NEU), an ethylating agent has been described as a very potent transplacental teratogen and carcinogen in rodents. Plants have been investigated to protect against the effect of environmental carcinogens due to their arrays of phytochemicals. 35Female albino rats of average ages 10weeks were rats exposed to freshly prepared 3 fractionated doses of 50 mg/kg N-Nitroso-N-ethyl urea dissolved in 1/15 M phosphate buffer, given intraperitoneally and treated with varying concentrations of Vernonia amygdalina leaf aqueous extracts. At the end of the test period, hematological and biochemical parameters were determined in blood samples. Compared to the control group, the NEU exposed rats treated group showed significances in several hematological parameters, including decreases in white blood cell (WBC), red blood cell (RBC), and platelet (PLT) counts. Furthermore, in comparison to the control group, the NEU exposed rats showed significantly (p<0.05) increased blood glucose, serum total cholesterol, low density lipoprotein (LDL-cholesterol), triacylglycerols levels and igh density lipoprotein (HDL-cholesterol) level. The hematological and biochemical parameters in the NEU exposed rats treated group were similar to control group. V. amygdalina extract significantly (P<0.05) restored the hematological and biochemical parameters in N-Nitroso-N-ethyl urea exposed rats

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Olugbenga, Olufunke T., and Joy E. Okpuzo. "Effects of Senna alata Aqueous Extract on the Hematological and Biochemical Alterations in Rats Exposed to N-Nitroso-N-Ethyl Urea." African Scientist 24, no. 2 (2023): 189–95. http://dx.doi.org/10.26538/africanscientist.24.2.20230606.

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The effect of carcinogen exposure has been established to alter biochemical and hematological profiles in humans. Secondary metabolites from plant sources like flavonoids, alkaloids, saponins, and others have been found to be potent anticancer agents and also investigated to protect against the effect of environmental carcinogens. Female albino rats were rats exposed to freshly prepared 3 fractionated doses of 50 mg/kg N-Nitroso-N-ethyl urea (carcinogen) dissolved in 1/15 M Phosphate buffer, given intraperitoneally and treated with varying concentrations of Senna alata plant aqueous extracts. At the end of the test period, hematological and biochemical parameters were determined in blood and serum samples. Compared to the control group, the carcinogen exposed rats treated group showed significances in several hematological parameters, including decreases in White blood cell (WBC), Red blood cell (RBC), and Platelet (PLT) counts. Furthermore, in comparison to the control group, the carcinogen exposed rats showed significantly increased blood glucose, serum total cholesterol, Low density lipoprotein (LDL-cholesterol), triacylglycerols levels and High density lipoprotein (HDL-cholesterol) level. The hematological and biochemical parameters in the carcinogen exposed rats treated group were approximately similar to control group. The S. alata extract significantly (P<0.05) restored the hematological and biochemical parameters in N-Nitroso-N-ethyl urea carcinogen exposed rats

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Guilmot, J. M., M. Godefroid, and M. Herman. "Rovibrational Parameters for trans-Nitrous Acid." Journal of Molecular Spectroscopy 160, no. 2 (1993): 387–400. http://dx.doi.org/10.1006/jmsp.1993.1186.

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Guilmot, J. M., F. Melen, and M. Herman. "Rovibrational Parameters for cis-Nitrous Acid." Journal of Molecular Spectroscopy 160, no. 2 (1993): 401–10. http://dx.doi.org/10.1006/jmsp.1993.1187.

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H. Ali1, Noor, Firas T. Maher1, and Mohammad M. F. Al-Halbosiy2. "The effect of hypertension, diabetes, and smoking on the levels of some biochemical parameters in chronic renal failure patients." Tikrit Journal of Pure Science 24, no. 3 (2019): 69. http://dx.doi.org/10.25130/j.v24i3.819.

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This study has been acomblished between December 2016 and September 2017 which included 70 patients with chronic renal failure who attended at Al-yarmuke teaching hospital in Baghdad with25 healthy individual as control. The research aims to study the effect of hypertension, diabetes and smoking on the levels of some biochemical parameters of chronic renal failure patients comparing with healthy control .The results showed a significant increase in the concentrations of urea, creatine, uric acid, cholesterol, Triglycerides(TG), low density lipoproteins (LDL) and Very low density lipoproteins (VLDL), compared to healthy control. The results also showed that hypertension has an effect on the concentration of urea, uric acid, creatinine, cholesterol, Triglycerides (TG), low density lipoproteins (LDL) and Very low density lipoproteins (VLDL), the results indicated that the diabetes has effects on the concentration of urea, creatinine, cholesterol and Triglycerides (TG), High density lipoproteins (HDL), low density lipoproteins( LDL) and Very Low density lipoproteins (VLDL) with no effects on the concentration of uric acid. There was an effect of smoking on The concentrations of cholesterol and the Triglycerides(TG), low Density Lipoproteins( LDL), Very Low density Lipoproteins (VLDL), urea, uric acid, and creatinine .The gender has no effect on the concentration of all measured parameters except on TG concentration  http://dx.doi.org/10.25130/tjps.24.2019.049

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Noor H. Ali, Firas T. Maher, and Mohammad M. F. Al-Halbosiy. "The effect of hypertension, diabetes, and smoking on the levels of some biochemical parameters in chronic renal failure patients." Tikrit Journal of Pure Science 24, no. 3 (2019): 69–76. http://dx.doi.org/10.25130/tjps.v24i3.370.

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This study has been acomblished between December 2016 and September 2017 which included 70 patients with chronic renal failure who attended at Al-yarmuke teaching hospital in Baghdad with25 healthy individual as control. The research aims to study the effect of hypertension, diabetes and smoking on the levels of some biochemical parameters of chronic renal failure patients comparing with healthy control .The results showed a significant increase in the concentrations of urea, creatine, uric acid, cholesterol, Triglycerides(TG), low density lipoproteins (LDL) and Very low density lipoproteins (VLDL), compared to healthy control. The results also showed that hypertension has an effect on the concentration of urea, uric acid, creatinine, cholesterol, Triglycerides (TG), low density lipoproteins (LDL) and Very low density lipoproteins (VLDL), the results indicated that the diabetes has effects on the concentration of urea, creatinine, cholesterol and Triglycerides (TG), High density lipoproteins (HDL), low density lipoproteins( LDL) and Very Low density lipoproteins (VLDL) with no effects on the concentration of uric acid. There was an effect of smoking on The concentrations of cholesterol and the Triglycerides(TG), low Density Lipoproteins( LDL), Very Low density Lipoproteins (VLDL), urea, uric acid, and creatinine .The gender has no effect on the concentration of all measured parameters except on TG concentration.

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Lukyanchenko, Oleksandr I., Oksana I. Mel'nyk, Olena A. Gozhenko, Walery Zukow, and Igor L. Popovych. "Features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress." Journal of Education, Health and Sport 10, no. 3 (2020): 177–87. https://doi.org/10.5281/zenodo.3753225.

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Lukyanchenko Oleksandr I., Mel’nyk Oksana I., Gozhenko Olena A., Zukow Walery, Popovych Igor L. Features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress. Journal of Education, Health and Sport. 2020;10(3):177-187. eISSN 2391-8306. DOI http://dx.doi.org/10.12775/JEHS.2020.10.03.020 https://apcz.umk.pl/czasopisma/index.php/JEHS/article/view/JEHS.2020.10.03.020 https://zenodo.org/record/3753225           The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2020; This article is published with open access at Licensee Open Journal Systems of Nicolaus Copernicus University in Torun, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited.  The authors declare that there is no conflict of interests regarding the publication of this paper.   Received: 05.02.2020. Revised: 15.02.2020. Accepted: 27.03.2020.             FEATURES OF THE HRV, ENDOCRINE AND METABOLIC PARAMETERS IN PERSONS WHOSE IMMUNE STATUS IS SUSCEPTIBLE OR RESISTANT TO CHRONIC STRESS   Oleksandr I. Lukyanchenko1, Oksana I. Mel’nyk2, Olena A. Gozhenko1, Walery Zukow3, Igor L. Popovych1,4   1Ukrainian Scientific Research Institute of Medicine for Transport, Odesa, Ukraine sofia.lukyanchenko@gmail.com; eago@ukr.net 2Danylo Halyts’kyǐ National Medical University, L’viv, Ukraine omelnyk7@gmail.com 3Nicolaus Copernicus University, Torun, Poland w.zukow@wp.pl 4OO Bohomolets’ Institute of Physiology, Kyїv, Ukraine i.popovych@biph.kiev.ua           Abstract Background. In the previous studies, we compared the individuals who were almost identical to the average value of LF/HF ratio and its dispersion, but with opposite deviations from the norm of immunity. Two profiles of EEG have been created that reflect the differences between the two clusters. The first profile contains the parameters that in stress-sensitive individuals are in the zone of narrowed norm, whereas in stress-resistant individuals they are to some degree elevated, or at least exceed those in stress-sensitive individuals. The second profile contains EEG parameters, each of which in stress-resistant individuals is lower than that of stress-sensitive individuals. The purpose of this study is to clarify the features of the HRV, endocrine and metabolic parameters in persons whose immune status is susceptible or resistant to chronic stress. Materials and Methods. The object of observation were 32 men and 8 women with chronic pyelonephritis in remission. The criterion for inclusion was the magnitude of the sympathico-vagal balance index LF/HF which exceeded the age norm by 0,5 σ. We determined spectral parameters of HRV, plasma levels of principal adaptation Hormones, plasma and daily urine levels of the Electrolytes and Nitrous metabolites as well as plasma Lipoproteines spectrum. Results. Discriminant analysis revealed that Testosterone is the main factor that conditioning the sensitivity of immune status to sympathotonic shift in autonomic regulation in chronic stress. Sensitizing (immunosuppressive) factors are also Ca/K-ratio of plasma and total Cholesterol, instead LD LP Cholesterol, Creatininuria, P/Ca-ratio of urine, spectral power of VLF band HRV as well as entropy of HRV are desensitizing (immunoprotective) factors. Conclusion. The susceptibility or resistance of the immune status to the stress sympathotonic shift of autonomic regulation is conditioned by the combination of EEG, HRV, endocrine and metabolic parameters.   Key words: Chronic Stress; Immunity; HRV; Hormones; Metabolism.

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Jameel, Ali H., Maeda M. T. Al-Sulaivany, Saad D. Oleiwi, and Mohammed J. Mohammed. "Physiological Effects of Nano-Magnesium Against Bisphenol A-induced Toxicity in Male Albino Rats." IOP Conference Series: Earth and Environmental Science 1262, no. 6 (2023): 062004. http://dx.doi.org/10.1088/1755-1315/1262/6/062004.

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Abstract This study was conducted to determine the effect of oral administration with two concentrations of 30% and 40% of nano-magnesium on Bisphenol-A in liver enzyme parameters (ALT, AST, ALP), kidney function and lipid profile of male white rats Bisphenol-The concentrations of triglycerides (TG), cholesterol (TC), low-density lipoproteins (LDL), and very low-density lipoproteins (vLDL) were all increased by A, whereas the concentration of high-density lipoproteins (HDL) was decreased. while liver enzyme parameters decreased noticeably. Nano-magnesium treatment led to decreases in levels of uric acid, creatinine, triglycerides, cholesterol, low-density lipoprotein, very low-density lipoprotein, and an increase in high-density lipoprotein (HDL) values.

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Tashkandi, Kaur, Latifi, et al. "Lipids, Lipoprotein Distribution and Nutritional Parameters over the Ramadan Period in Hemodialysis Patients." Nutrients 11, no. 9 (2019): 2225. http://dx.doi.org/10.3390/nu11092225.

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The period of Ramadan (R) is associated with dramatic changes in eating habits involving extended periods of fasting on a daily basis. The current study assessed whether lipids and lipoproteins were impacted during R in chronic hemodialysis (HD) patients. Forty-five subjects in an outpatient dialysis clinic in Saudi Arabia were evaluated for anthropometric and lipid changes on a monthly basis before, during as well as one and two months after R. In addition to routine biochemical measures, anthropometric assessments including hand-grip strength (HGS), mid-arm muscle circumference (MAMC), plasma lipids and lipoproteins were evaluated. Dietary assessment was carried out using 24 h recalls. Over the course of the study, changes in renal-related parameters (creatinine, albumin, Kt/V) were minor, as were changes in plasma lipids. Large high-density lipoproteins (HDLs) and low-density lipoproteins (LDLs) accounted for the majority of their respective lipoproteins and their proportions did not change over the study period. Mean LDL particle diameters were higher during the R period, but the changes over the study period were small. Calorie intake during R (2139 ± 709 kcal/d) was significantly higher than the value noted two month post-R (1755 ± 424 kcal/d) and this was associated with significant increases in protein (69 ± 24 vs. 60 ± 24 g/d) and fat (97 ± 38, vs. 73 ± 35 g/d), respectively. No changes were noted with respect to HGS and MAMC. These data show that for HD patients, the period of R results in temporal or non-significant effects on plasma lipids, despite changes in nutrient intake.

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Deng, Yunkun, Dengming Xiao, Xuewen Li, and Xiaofei Gao. "Measurement of Electron Swarm Parameters in Nitrous Oxide." Plasma Science and Technology 15, no. 5 (2013): 425–28. http://dx.doi.org/10.1088/1009-0630/15/5/06.

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Śmierciak, Natalia, Wirginia Krzyściak, Marta Szwajca, et al. "Benefits and Meaning of Lipids Profile in Relation to Oxidative Balance and Brain Morphology in Schizophrenia." International Journal of Molecular Sciences 24, no. 14 (2023): 11375. http://dx.doi.org/10.3390/ijms241411375.

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Schizophrenia is characterized by complex metabolic dysregulations and their consequences. Until now, numerous theories have explained its pathogenesis, using a spectrum of available technologies. We focused our interest on lipid profile—periphery high-density cholesterol level and lipoproteins in the human brain and compared magnetic resonance imaging (MRI) scans of patients with schizophrenia and the healthy group. Detailed analysis of biochemical parameters was performed using magnetic resonance spectroscopy. Our study aimed to reveal correlations between periphery high-density lipoproteins levels and lipoproteins in the brain, depicted in MRI scans, and parameters of peripheral oxidative stress expressed as paraoxonase. Patients with schizophrenia have decreased levels of high-density lipoproteins, low paraoxonase activity, and slightly raised sodium in the blood. Positive significant correlations between serum high-density cholesterol and anterior cingulate cortex, unique brain area for schizophrenia pathophysiology, MR spectroscopy signals, and diffusion have been revealed. To our knowledge, this is the first study to describe the effect of an anterior cingulate disorder on high-density cholesterol levels on the development of schizophrenia.

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Wicht, H. "A model for predicting nitrous oxide production during denitrification in activated sludge." Water Science and Technology 34, no. 5-6 (1996): 99–106. http://dx.doi.org/10.2166/wst.1996.0540.

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To examine the importance of certain conditions on the production of nitrous oxide during denitrifications batch experiments with activated sludge were conducted. With the obtained parameters and a Monod kinetics based model the nitrous oxide concentrations in a CSRT were calculated. The influence of temperature, pH, nitrate influent concentration, readily biodegradable COD influent concentration, H2S and oxygen inhibitor concentrations are discussed. The presented model helps in understanding some previously described phenomena of nitrous oxide production in wastewater treatment plants.

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Iannuzzi, Arcangelo, Paolo Rubba, Marco Gentile, et al. "Carotid Atherosclerosis, Ultrasound and Lipoproteins." Biomedicines 9, no. 5 (2021): 521. http://dx.doi.org/10.3390/biomedicines9050521.

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Carotid artery plaques are considered a measure of atherosclerosis and are associated with an increased risk of atherosclerotic cardiovascular disease, particularly ischemic strokes. Monitoring of patients with an elevated risk of stroke is critical in developing better prevention strategies. Non-invasive imaging allows us to directly see atherosclerosis in vessels and many features that are related to plaque vulnerability. A large body of evidence has demonstrated a strong correlation between some lipid parameters and carotid atherosclerosis. In this article, we review the relationship between lipids and atherosclerosis with a focus on carotid ultrasound, the most common method to estimate atherosclerotic load.

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Kadhum Jhyied Gatie and Tayseer Shamran Al-Deresawi. "Study of physiological and cytogenetic changes to males patients with diabetic mellitus type2 by used the body mass index." Journal of Wasit for Science and Medicine 8, no. 3 (2022): 15–30. http://dx.doi.org/10.31185/jwsm.287.

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The study included 20 patients and have ranged in age from (30-75 years), compared with a control groups which included 12 individual, with ages have ranged from (38-70) years. The study investigate biochemical parameters included measuring the levels of each of (Total Cholesterol , Triglyceride , low-density lipoproteins, high density lipoproteins , lipoproteins very low density, and measuring hormone levels Testosterone, and estimate the damage in DNA and measuring the Micronucleus and Mitotic index and analysis of Comet Assay in lymphocytes for patients and control: The results of our study showed a high change (P< 0.05) in the level of each of (cholesterol, triglycerides , low-density lipoproteins , lipoproteins very low density , and the low significant (P< 0.05) level of high density lipoproteins and of the Testosterone hormone .The results showed a high significant (P< 0.05) in the Mitotic index and Micronucleus , appearance of numbers low in the number the Nuclear division index, where results showed a high significant (P< 0.05) in damage to the DNA molecule by comet assay when compared with control group.

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Shahab, M. Asif, Mohsin Ali Hassni, M. Iqbal, et al. "Metabolites of Rusuvastatin Inhibit Oxidation of both Low-Density Lipoproteins and Very Low-Density Lipoproteins." Global Academic Journal of Pharmacy and Drug Research 5, no. 06 (2023): 64–68. http://dx.doi.org/10.36348/gajpdr.2023.v05i06.002.

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Coronary Artery Disease is caused by plaque buildup in the walls of the arteries that supply blood to the heart (called coronary arteries) and other parts of the body. Plaque is made up of deposits of cholesterol and other substances in the artery. Plaque buildup causes the inside of the arteries to narrow over time, which could partially or totally block the blood flow. This process is called atherosclerosis. Coronary artery disease (CAD), when get worst, it is known as coronary artery syndrome (CAS). There are many allopathic medications which can stop, even at starting points of the disease (CAD). Hypolipidemic drugs like statins, fibrates, resins and niacin are well known agents used for prevention of CAD. There are ethnic-based medicinal herbs which can be used to treat or prevent CAD with narrow to moderate range of statistical significance. We compared Rosuvastatin 10 mg with Indian dates (Jujubes) as hypolipidemic agents. This research was conducted at Ghurki Trust Teaching Hospital, jalo park, Lahore, Pakistan. Duration of study was two months. Twenty to seventy years old 60 hyperlipidemic patients of both gender were included in research work with written consent. We divided these patients in two equal groups. Group-I was advised to take Tablet Rosuvastatin 10 mg, twice daily for two months. Group-II was advised to take 500 grams Indian dates for two months. Their baseline parameters like LDL-cholesterol, HDL-cholesterol, systolic/diastolic blood pressure was determined in the hospital laboratory. Separate file was maintained for their name, age, sex, occupation, and address. After two months therapy we compiled data related to tested parameters. Paired t-test was applied to compare changes in all parameters. Their mean values with ± SD before and after treatment were compared and analyzed statistically. It was observed that Rosuvastatin significantly decreased systolic/diastolic blood pressure, LDL-cholesterol, and increased HDL-cholesterol in 27 hyperlipidemic/hypertensive patients. Indian dates used in 30 hyperlipidemic patients significantly decreased systolic blood pressure, and LDL-cholesterol, but insignificant changes were seen in diastolic blood pressure, and HDL-cholesterol. We concluded from the research work that Rosuvastatin is potent hypolipidemic and hypotensive medicine as compared to indian dates.

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Ozsavci, Derya, A. Nazli, O. Bingol Ozakpinar, G. Yanikkaya Demirel, B. Vanizor Kural, and A. Sener. "Native High-Density Lipoprotein and Melatonin Improve Platelet Response Induced by Glycated Lipoproteins." Folia Biologica 64, no. 4 (2018): 144–52. http://dx.doi.org/10.14712/fb2018064040144.

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Activated platelets and glycated lipoproteins are responsible for atherothrombosis in diabetics. Melatonin and native high-density lipoproteins are crucial in the preservation of pro/oxidant-antioxidant balance. The aim of the present study was to investigate the in vitro effects of native high-density lipoproteins and melatonin on altering the platelet response induced by glycated lipoproteins. Low-density lipoproteins and high-density lipoproteins were purified from plasma by ultracentrifugation and were glycated with glucose for three weeks. After incubation with or without melatonin/or native highdensity lipoproteins, low-density lipoproteins, glycated low-density lipoproteins/glycated high-density lipoproteins were added to ADP-induced platelets. Oxidative parameters, caspase-3/9 and nitric oxide levels were measured spectrophotometrically; CD62-P/ annexin-V expression was determined by flow cytometry. In glycated low-density lipoprotein/glycated high-density lipoprotein-treated groups, platelet malondialdehyde/ protein carbonyl, P-selectin, annexin-V, caspase-3/9 levels were increased (ranging from P < 0.001 to P < 0.01); glutathione and nitric oxide levels were reduced (ranging from P < 0.001 to P < 0.01). In glycated low-density lipoprotein/glycated high-density lipoprotein-treated groups, melatonin treatment reduced malondialdehyde, protein carbonyl, CD62-P, annexin-V and caspase-3/9 (P < 0.001, P < 0.01) levels and elevated nitric oxide (only glycated low-density lipoproteins). In glycated low-density lipoprotein/glycated high-density lipoprotein-treated groups, native high-density lipoprotein treatment reduced malondialdehyde, protein carbonyl, annexin-V, caspase-3/9 levels (P < 0.001, P < 0.01) and increased glutathione; nitric oxide levels (only with gly-HDL). Both melatonin and high-density lipoproteins should be regarded as novel promising mechanism-based potential therapeutic targets to prevent atherothrombosis in diabetics.

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Farooq, Hussain, Yousaf Ali, Aleema Ali, Mustafa Nadeem, and Ghazanfar Ali Sirhindi. "Evaluation of Lipid Profiles and Hematological Parameters in Hypertensive Patients." Pakistan Journal of Medical and Health Sciences 16, no. 9 (2022): 132–34. http://dx.doi.org/10.53350/pjmhs22169132.

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Aim: To evaluate the lipid profiles and hematological parameters in hypertensive patients. Study design: Cross sectional analytical study Place and duration of study: Department of Hematology, Shaikh Zayed Hospital, Lahore from 1st July 2021 to 31st December 2021. Methodology: Eighty hypertensive patients within the age group of 25-65 years were enrolled. A 5-cc blood was withdrawn from each study patient for analysis of their complete lipid profile including triglycerides, cholesterol, low density lipoproteins, high density lipoproteins as well as for hematological parameters analysis which included red blood cells, white blood cells hematocrits, hemoglobin, red blood cell indices and platelets. Result: The mean age of the patients was 51.89±12.47 years. There were 45 males and 35 females in this study. Obesity was more common in hypertensive women than men. Lipid profile except high density lipoproteins was significantly higher in patients with uncontrolled blood pressure levels. High red blood cells were observed in both males and females with uncontrolled blood pressure while the platelets level decreased in uncontrolled BP males and increased in uncontrolled BP females in comparison to controlled males and females respectively. An increased level of hemoglobin and hematocrit in patients from both genders with uncontrolled blood pressure was observed. Conclusion: Disturbed lipid profile and hematological parameters imbalances are related with the hypertension Key words: Lipid profile, Hematological parameters, Hypertension

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Ignatov, A. S., N. V. Vernikovskaya, V. A. Chumachenko, and A. S. Noskov. "Modeling of the nitrous oxide synthesis in a microchannel reactor: the effect of parameters on the temperature regimes and output." Kataliz v promyshlennosti 1, no. 1-2 (2021): 74–85. http://dx.doi.org/10.18412/1816-0387-2021-1-2-74-85.

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The study deals with the synthesis of nitrous oxide via selective oxidation of ammonia in a microreactor (MCR), which is a metal disk with cylindrical channels filled with the manganese-bismuth oxide catalyst. The proposed 3D mathematical model of MCR takes into account axial and radial heat and mass transfer, catalytic reactions and related changes of the reaction mixture volume, heat exchange between the disk and channels, and thermal conductivity of the disk. Parameters providing the maximum output of nitrous oxide were determined with allowance for restrictions on the temperature in MCR channels. The highest efficiency of the nitrous oxide synthesis is achieved at a temperature of the outer edge of reactor 370 °С and an inlet concentration of ammonia 20 vol.%. The output per unit catalyst volume in MCR is approximately 1.5 times higher as compared to a tubular reactor; the maximum temperature corresponds to the optimal one, which provides the best selectivity of the process with respect to nitrous oxide.

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Amorim, Pedro, Geoffrey Chambers, James Cottrell, and Ira S. Kass. "Nitrous Oxide Impairs Electrophysiologic Recovery after Severe Hypoxia in Rat Hippocampal Slices." Anesthesiology 87, no. 3 (1997): 642–51. http://dx.doi.org/10.1097/00000542-199709000-00026.

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Background Research has suggested that nitrous oxide may be harmful to ischemic neurons; however, the evidence for this is equivocal. The authors used rat hippocampal slices to examine the effects of nitrous oxide on neuronal hypoxic damage. Methods The evoked population spike (PS) was recorded from hippocampal CA1 pyramidal cells before, during, and after hypoxia. Control groups received nitrogen concentrations equal to nitrous oxide throughout the experiments. Biochemical measurements were made from dissected CA1 regions under experimental conditions that matched the electrophysiology studies. Results Recovery of the PS after hypoxia was 18 +/- 7% in slices treated with 50% nitrous oxide before and during 3.5 min of hypoxia; this compares with 41 +/- 9% (P &lt; 0.05) in nitrogen-treated slices. Slices treated with nitrous oxide (95%) only during hypoxia (6 min) also demonstrated significantly less recovery of the PS than did slices treated with nitrogen. There was no significant difference in recovery if nitrous oxide was discontinued after the hypoxic period. Adenosine triphosphate concentrations after 3.5 min of hypoxia in slices treated with nitrous oxide decreased to the same extent as in nitrogen-treated slices (47% vs. 50%). Calcium influx increased during 10 min of hypoxia in untreated slices, but nitrous oxide did not significantly increase calcium influx during hypoxia. The sodium concentrations increased and potassium concentrations decreased during hypoxia; nitrous oxide did not significantly alter these changes. Conclusions Nitrous oxide impaired electrophysiologic recovery of hippocampal slices after severe hypoxia. Nitrous oxide did not cause significant changes in the biochemical parameters examined.

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Goyel, Vinita, Aman Jain, Shivani Mathur, Vinod Sachdev, and Shambhavi Singh. "Exploring the Effect on 5 Senses in Children under Nitrous Oxide Sedation." Journal of Evolution of Medical and Dental Sciences 10, no. 38 (2021): 3365–69. http://dx.doi.org/10.14260/jemds/2021/683.

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BACKGROUND Sensation and perception are two separate processes that are very closely related. Sensation is the input about the outside world obtained by our sensory receptors while perception is the difficult system by which the brain selects, organizes and interprets these sensations. Effects of nitrous oxide on the sensation and perception has not been unturned although role in physiological, anxiolytic, behavioural, psychomotor and analgesic parameters have been examined in both children and adults. The human senses have long been unnoticed, despite their responsiveness being of great importance. The purpose of this study was to evaluate the effectiveness of nitrous oxide inhalation sedation on 5 senses i.e. sight, hearing, touch, smell and taste at different titrations of nitrous oxide and oxygen. METHODS 7 to 12 years old children with Frankl’s behaviour rating score of 2, 3 and 4 with no prior dental experience and requiring dental treatment under nitrous oxide sedation who were systemically healthy were included in the study. The 5 senses (i.e. hearing, touch, smell, taste and vision) were evaluated with different materials at 4 different titration levels to evaluate the effect of nitrous oxide on the 5 senses T0: 100 % oxygen, T1: 30 % nitrous oxide, T2: 50 % nitrous oxide, T3: 100 % oxygen. RESULTS The results of the present study depicted that there is significant difference in the perception of various senses at different concentrations of nitrous oxide and also when compared to baseline values. It was observed that the patient regained the normal perception in 5 minutes after 100 % oxygen post-operatively. CONCLUSIONS Nitrous oxide is found to depress/relax one’s senses too. KEY WORDS Vision, Smell, Taste, Touch, Sound, Perception, Consciousness, Nitrous Oxide Sedation, Oxygen, Behaviour

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Rossaint, Rolf, Matthias Reyle-Hahn, Jochen Schulte am Esch, et al. "Multicenter Randomized Comparison of the Efficacy and Safety of Xenon and Isoflurane in Patients Undergoing Elective Surgery." Anesthesiology 98, no. 1 (2003): 6–13. http://dx.doi.org/10.1097/00000542-200301000-00005.

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Background All general anesthetics used are known to have a negative inotropic side effect. Since xenon does not have a negative inotropic effect, it could be an interesting future general anesthetic. The aim of this clinical multicenter trial was to test the hypothesis of whether recovery after xenon anesthesia is faster compared with an accepted, standardized anesthetic regimen and that it is as effective and safe. Method A total of 224 patients in six centers were included in the protocol. They were randomly assigned to receive either xenon (60 +/- 5%) in oxygen or isoflurane (end-tidal concentration, 0.5%) combined with nitrous oxide (60 +/- 5%). Sufentanil (10 mcirog) was intravenously injected if indicated by defined criteria. Hemodynamic, respiratory, and recovery parameters, the amount of sufentanil, and side effects were assessed. Results The recovery parameters demonstrated a statistically significant faster recovery from xenon anesthesia when compared with isoflurane-nitrous oxide. The additional amount of sufentanil did not differ between both anesthesia regimens. Hemodynamics and respiratory parameters remained stable throughout administration of both anesthesia regimens, with advantages for the xenon group. Side effects occurred to the same extent with xenon in oxygen and isoflurane-nitrous oxide. Conclusion This first randomized controlled multicenter trial on the use of xenon as an inhalational anesthetic confirms, in a large group of patients, that xenon in oxygen provides effective and safe anesthesia, with the advantage of a more rapid recovery when compared with anesthesia using isoflurane-nitrous oxide.

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Joseph, Eberendu, Kazuyuki Sakata, Tetsumei Urano, Yumiko Takada, and Akikazu Takada. "Lipids, Lipoproteins and Fibrinolytic Parameters During Amlodipine Treatment of Hypertension." JOURNAL OF HEALTH SCIENCE 46, no. 6 (2000): 455–58. http://dx.doi.org/10.1248/jhs.46.455.

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Sanguigni, V., M. Gallu`, R. De Cristofaro, C. Levi, L. Sciarra, and A. Strano. "Effects of physical activity on serum lipoproteins and coagulation parameters." Atherosclerosis 109, no. 1-2 (1994): 154–55. http://dx.doi.org/10.1016/0021-9150(94)93630-7.

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Płaczkowska, Sylwia, Katarzyna Sołkiewicz, Iwona Bednarz-Misa, and Ewa Maria Kratz. "Atherogenic Plasma Index or Non-High-Density Lipoproteins as Markers Best Reflecting Age-Related High Concentrations of Small Dense Low-Density Lipoproteins." International Journal of Molecular Sciences 23, no. 9 (2022): 5089. http://dx.doi.org/10.3390/ijms23095089.

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The study aimed to assess the strength of the relationships between small dense low-density lipoproteins (sdLDL) and other parameters describing metabolic disorders and determine which of the lipid profile parameters can be used as markers of increased sdLDL concentration. The proposed model of sdLDL (examined by heparin–magnesium precipitation method) as a function of lipid parameters and atherogenic plasma indexes non-high-dense lipoproteins (non-HDL) and total cholesterol to high-dense lipoprotein ratio (TC/HDL), Atherogenic plasma index (API) is based on data from 485 participants divided into two age groups, <35≥ years. In multiple linear regression, sdLDL concentration was associated with the concentration of non-HDL-C (p = 0.043) and API value (p < 0.001) in participants <35 years, and with non-HDL-C (p < 0.001) and triglycerides (p = 0.020) concentration ≥35 years. The presence of abnormal values of API in participants <35 years and non-HDL-C in participants ≥35 years is a significant factor increasing the chances of the highest sdLDL (≥1.03 mmol/L) corresponding to Q4 in people without metabolic disorders. Different lipid parameters and atherogenicity indexes are associated with a high concentration of sdLDL depending on the age group. Abnormal API <35 years and non-HDL ≥35 years are associated with the highest sdLDL values and may be an indication for further specialist diagnosis of cardiovascular disease risk factors.

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Abdul-Aziz Kadir, Mohammed, and Narmeen RafikHamad. "Biochemical parameters in patients with Trichomonasvaginalis and Toxoplasma gondii in Erbil-Iraq." Tikrit Journal of Pharmaceutical Sciences 9, no. 2 (2023): 327–37. http://dx.doi.org/10.25130/tjphs.2013.9.2.16.327.327.

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This study investigated the biochemical parameters of two parasites, Trichomonasvaginalis and Toxoplasma gondii among females attending the gynaecological out patients clinics in MaternityRizgaryHospital, several health centers and some private clinics in Erbil-Iraq, from 16th July 2007 till 15th July 2008, by using different diagnostic methods. In addition, a comparative study to evaluate the biochemical changes due to tichomoniasis and toxoplasmosis. The serum samples were examined for some biochemical parameters like cholesterol, triglycerides, high density lipoproteins-cholesterol (HDL-C), low density lipoproteins-cholesterol (LDL-C), total proteins, albumin, globulin, with some elements such as calcium, sodium, potassium, chloride, iron, copper and zinc. Infection with Trichomonasvaginalis had no significant effects on the studied biochemical parameters among non-pregnant women. Toxoplasma gondii causes a significant decrease in total protein level among non-pregnant women, while in pregnant women, reduced calcium level was observed

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Esson, A. E., A. K. Adamu, M. A. Adelanwa, and M. I. Adebola. "NITROUS ACID-INDUCED VARIATIONS IN SOME QUANTITATIVE TRAITS OF THE FOXTAIL MILLET SETARIA ITALICA (L.) P. BEAUV." Journal of Scientific Agriculture 1 (December 2, 2017): 303. http://dx.doi.org/10.25081/jsa.2017.v1.844.

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The effects of different concentrations of nitrous acid on the agronomic parameters of foxtail millet were investigated. Seeds treated with different concentrations of nitrous acid and untreated seeds (control) were planted in a Randomized Completely Block Design (RCBD) for two generations. The following data collected: percent germination, plant height, leaf number, length, and width, fresh and dry weights, number of days to 50% flowering, panicle length, and weight, and 1000-seed weight. Significant variations were observed in plant height, leaf number and length, fresh and dry weights, panicle length and weight, and 1000-seed weight in the control. Plant height, leaf length, fresh weight and dry weight had highest mean values at 0.1% nitrous acid. Number of leaves and panicle length and weight were highest at 0.4% concentration, while 1000-seed weight was highest with 0.3% nitrous acid. From this experiment, nitrous acid proved to be effective in inducing mutations that increased quantitative traits of the foxtail millet. The mutations have great potentials which can be harnessed for use in a breeding programme.

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Kuz'micheva, Galina, Vladimir Chernyshev, Galina Kravchenko, et al. "Impact of composition and structural parameters on the catalytic activity of MFI type titanosilicalites." Dalton Transactions 51, no. 9 (2022): 3439–51. http://dx.doi.org/10.1039/d1dt04131b.

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Czapski, Grzegorz, Aleksandra Maruszak, Maria Styczynska, Cezary Zekanowski, Krzysztof Safranow, and Joanna Strosznajder. "Association between plasma biomarkers, CDK5 polymorphism and the risk of Alzheimer’s disease." Acta Neurobiologiae Experimentalis 72, no. 4 (2012): 397–411. http://dx.doi.org/10.55782/ane-2012-1911.

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In this study we evaluated biochemical blood serum parameters and the association of Cyclin-dependent kinase 5 (CDK5) gene polymorphisms with the risk of Alzheimer’s disease (AD) in the Polish population. We observed an elevated total cholesterol, low-density lipoproteins (LDL) and homocysteine levels and lower concentrations of high-density lipoproteins (HDL) and vitamin B12 in AD patients. However, the analyzed CDK5 polymorphisms were not associated with the biochemical parameters. Moreover, we found no association between the studied polymorphisms and the risk of AD in the Polish population. The meta-analysis of previously published and current study was performed. In conclusion, our study demonstrated that alteration of cholesterol, LDL, HDL, homocysteine and B12 concentration may be an important factor in pathogenesis of AD.

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Selvakumar, Kandaswamy, Senthamilselvan Bavithra, Sekaran Suganya, Firdous Ahmad Bhat, Gunasekaran Krishnamoorthy, and Jagadeesan Arunakaran. "Effect of Quercetin on Haematobiochemical and Histological Changes in the Liver of Polychlorined Biphenyls-Induced Adult Male Wistar Rats." Journal of Biomarkers 2013 (October 1, 2013): 1–12. http://dx.doi.org/10.1155/2013/960125.

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Polychlorinated biphenyls exposure damages the rat liver cells. Hematological parameters such as hemoglobin, packed cell volume, red-blood cells, white-blood cells, neutrophils, platelet counts, and RBC indices were significantly decreased. Polymorphs, eosinophil counts, and erythrocyte sedimentation rate were significantly increased. Serum liver enzymes such as aspartate transaminase, alanine transaminase, alkaline phosphatase, and gamma-glutamyl transferase were increased by PCBs treatment. Serum lipid profiles such as cholesterol, triglycerides, low-density lipoproteins and very-low-density lipoproteins were increased in PCBs-treated rats. High-density lipoprotein, total protein, albumin, globulin levels, and albumin/globulin ratio were also decreased after PCB exposure. Then levels of sodium, potassium, chloride, and bicarbonate were also altered. Serum glucose levels were increased along with total bilirubin after PCBs exposure. Simultaneous quercetin supplementation significantly protected the PCBs-induced changes of hematobiochemical parameters. Thus, quercetin shows a protective role against PCBs-induced alterations in the hematological and biochemical parameters.

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Koffi, Yannick, Samuel Yeo, Corinne Pottier, and Philippe Niclot. "Disturbances in Biological Parameters in Patients Exposed to Nitrous Oxide Abuse Experience of the Rene Dubos Hospital Centre in Pontoise." Advances in Biochemistry 12, no. 3 (2024): 99–104. http://dx.doi.org/10.11648/j.ab.20241203.12.

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Nitrous oxide abuse is increasingly common among young people. It&apos;s a gas consumed at parties, where access is easy and less expensive. It can cause vitamin deficiencies, leading to neurological and non-neurological clinical manifestations. The aim of this study was to establish the blood biology profile of patients hospitalized for neurological disorders in the context of nitrous oxide abuse. Methodology, we conducted a retrospective and prospective descriptive study from January 2021 to April 2023. We studied frequency of consumption, inhaled dose and time of exposure to nitrous oxide. Blood levels of vitamin B12 and B9 were measured. Methylmalonic acid and homocysteine were also measured in the blood. Results include 15 patients recruited during the study period. 7 of the 15 patients used nitrous oxide daily. One patient consumed 9600 grams per week. Ten patients had a delay in toxicity beyond one year. Vitamin B12 blood levels were normal in 8 of 15 patients. On average, vitamin B12 levels were normal at 207.57 pmol/l. Vitamin B9 was not routinely measured in 9 patients. Blood homocysteine levels were elevated in 12 of 13 patients, with a high mean of 83.36 µmol/l. In conclusion, blood homocysteine levels are a more reliable marker than vitamin B12 for demonstrating biological disturbances associated with laughing gas abuse.

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Inger, Marek, Agnieszka Dobrzyńska-Inger, Jakub Rajewski, and Marcin Wilk. "Optimization of Ammonia Oxidation Using Response Surface Methodology." Catalysts 9, no. 3 (2019): 249. http://dx.doi.org/10.3390/catal9030249.

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In this paper, the design of experiments and response surface methodology were proposed to study ammonia oxidation process. The following independent variables were selected: the reactor’s load, the temperature of reaction and the number of catalytic gauzes, whereas ammonia oxidation efficiency and N2O concentration in nitrous gases were assumed as dependent variables (response). Based on the achieved results, statistically significant mathematical models were developed which describe the effect of independent variables on the analysed responses. In case of ammonia oxidation efficiency, its achieved value depends on the reactor’s load and the number of catalytic gauzes, whereas the temperature in the studied range (870–910 °C) has no effect on this dependent variable. The concentration of nitrous oxide in nitrous gases depends on all three parameters. The developed models were used for the multi-criteria optimization with the application of desirability function. Sets of parameters were achieved for which optimization assumptions were met: maximization of ammonia oxidation efficiency and minimization of the N2O amount being formed in the reaction.

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Zelcer, J., H. Owers, and J. D. Paull. "A Controlled Oximetric Evaluation of Inhalational, Opioid and Epidural Analgesia in Labour." Anaesthesia and Intensive Care 17, no. 4 (1989): 418–21. http://dx.doi.org/10.1177/0310057x8901700404.

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The effects on patient oxygenation of nitrous oxide, narcotic and epidural analgesia in labour were evaluated using pulse oximetry. Five groups of ten patients received either no analgesia (Control, Group I), an epidural block alone (Group 2), nitrous oxide in oxygen alone (Group 3), intramuscular pethidine (Group 4), or nitrous oxide in oxygen combined with intramuscular pethidine (Group 5). Derived parameters included the maximum (MAX), minimum (MIN), average maximum (AV MAX), and average minimum (AV MIN) arterial haemoglobin oxygen saturation (Sao2), and differences between maxima and minima (MAX-MIN). There was a statistically significant difference between Group 1 and Group 5 for MIN, AV MIN and MAX-MIN SaO2 (P < 0.05). All other groups showed no significant difference in any parameter when compared with the control group. The results are discussed with reference to normal and disordered maternal physiological changes in pregnancy. It is suggested that nitrous oxide should not be used for analgesia in labour where there is concern about maternal, placental or foetal reserve.

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Arfuso, Francesca, Claudia Giannetto, Marilena Bazzano, Anna Assenza, and Giuseppe Piccione. "Physiological Correlation between Hypothalamic–Pituitary–Adrenal Axis, Leptin, UCP1 and Lipid Panel in Mares during Late Pregnancy and Early Postpartum Period." Animals 11, no. 7 (2021): 2051. http://dx.doi.org/10.3390/ani11072051.

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This study aimed to investigate the dynamic change of adrenocorticotrophic hormone (ACTH), cortisol, leptin, mitochondrial uncoupling protein 1 (UCP1), lipids and lipoproteins in mares during late pregnancy and the postpartum period. A total of 20 mares (10 pregnant mares, monitored from 14 ± 2 days before expected foaling until 14 days after foaling, Group A; 10 non-pregnant and non-lactating mares, Group B) were enrolled in the study. Body Condition Score (BCS) and body weight (BW) values were recorded from each animal. In Group A, blood samples were collected on days 14 ± 2 and 7 ± 2 before foaling (T−14; T−7), and on days 7 and 14 after foaling (T+7; T+14). From mares of Group B, blood samples were collected at the beginning of the study. The levels of ACTH, cortisol, leptin, UCP1, non-esterified fatty acids (NEFAs), total cholesterol, high-density lipoproteins (HDLs), low-density lipoproteins (LDLs), triglycerides and very-low-density lipoproteins (VLDLs) were investigated. While BCS showed no statistical change throughout the monitoring period (p > 0.05), all the other studied parameters displayed statistically significant variations in Group A over the peripartum period (p < 0.0001). A significant effect of pregnancy was found on all studied parameters (p < 0.001). The ACTH and cortisol levels measured in mares belonged to Group A showed a significant positive correlation with the values of leptin, LDLs, triglycerides and VLDLs, whereas they were negatively correlated with the serum UCP1 and NEFAs values. Together, the findings gathered in this study highlight a dynamic change of serum leptin, UCP1 and lipid parameters in peripartum mares and suggest an interaction of the HPA axis with lipid metabolism and mobilization in mares during the peripartum period in order to deal with metabolic and energy demand and maintain energy homeostasis.

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Vereecke, Hugo E. M., Johannes H. Proost, Bjorn Heyse, et al. "Interaction between Nitrous Oxide, Sevoflurane, and Opioids." Anesthesiology 118, no. 4 (2013): 894–902. http://dx.doi.org/10.1097/aln.0b013e3182860486.

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Abstract Background: The interaction of sevoflurane and opioids can be described by response surface modeling using the hierarchical model. We expanded this for combined administration of sevoflurane, opioids, and 66 vol.% nitrous oxide (N2O), using historical data on the motor and hemodynamic responsiveness to incision, the minimal alveolar concentration, and minimal alveolar concentration to block autonomic reflexes to nociceptive stimuli, respectively. Methods: Four potential actions of 66 vol.% N2O were postulated: (1) N2O is equivalent to A ng/ml of fentanyl (additive); (2) N2O reduces C50 of fentanyl by factor B; (3) N2O is equivalent to X vol.% of sevoflurane (additive); (4) N2O reduces C50 of sevoflurane by factor Y. These four actions, and all combinations, were fitted on the data using NONMEM (version VI, Icon Development Solutions, Ellicott City, MD), assuming identical interaction parameters (A, B, X, Y) for movement and sympathetic responses. Results: Sixty-six volume percentage nitrous oxide evokes an additive effect corresponding to 0.27 ng/ml fentanyl (A) with an additive effect corresponding to 0.54 vol.% sevoflurane (X). Parameters B and Y did not improve the fit. Conclusion: The effect of nitrous oxide can be incorporated into the hierarchical interaction model with a simple extension. The model can be used to predict the probability of movement and sympathetic responses during sevoflurane anesthesia taking into account interactions with opioids and 66 vol.% N2O.

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Kuffour, Osei B., Christopher Larbie, Afua K. A. Genfi, and Richard Sedeafor. "The Haematology and Serum Biochemistry of Traditional Textile Dyers in Ntonso, Kumasi were Affected by Exposure to Synthetic Textile Dyes." Journal of Applied Life Sciences International 26, no. 5 (2023): 66–73. http://dx.doi.org/10.9734/jalsi/2023/v26i5620.

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Aim: To study the effects of synthetic textile dyes on haematology and serum biochemistry of traditional textile industry practitioners at Ntonso in the Ashanti region of Ghana. Study Design: Case-control study. Place and Duration of Study: The study was carried out at Ntonso in the Ashanti region of Ghana and clinical analyses were carried out at the Clinical Analyses Laboratory at the Department of Biochemistry and Biotechnology, KNUST between October 2018 and February 2019. Methodology: This study was conducted on 50 textile dyeing practitioners who have been using synthetic textile dyes for more than five years and 50 participants in the control group whose daily work does not expose them to any kind of synthetic textile dye. Participants over 70 years or less than 18 years, pregnant women and those with a medical history of kidney and liver diseases were excluded from the study. Haematological parameters such as White Blood Cell (WBC) counts, Red Blood Cell (RBC) counts, Platelet counts, Haemoglobin levels, etc. were measured. Liver function indicators such as Alanine transaminase (ALT), Protein, Aspartate aminotransferase (AST), Alkaline Phosphatase (ALP), Gamma-glutamyl transferase (GGT), Total Bilirubin (TBIL), and kidney function indicators such as Creatinine, urea, Na, K, Cl ion levels were assessed. Lipid profile parameters such as Total Cholesterol, Triglycerides, High-Density Lipoproteins, Low-Density Lipoproteins (LDL), and Very Low-Density Lipoproteins (VLDL) levels were also assessed. Results: There were statistical differences in both groups regarding key haematological and key serum biochemical parameters such as protein, globulin, ALP, GGT, creatinine, chloride, VLDL and Triglyceride. A significant correlation was observed between the metal ions and haematological parameters, biochemical parameters and quantity of dye used. Conclusion: Heavy metals found in synthetic textile dyes altered lipid profile, haematological and biochemical parameters of the dye practitioners.

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Khan, Rehana, Sajib K. Saha, Shaun Frost, Yogesan Kanagasingam, and Rajiv Raman. "The Longitudinal Assessment of Vascular Parameters of the Retina and Their Correlations with Systemic Characteristics in Type 2 Diabetes—A Pilot Study." Vision 6, no. 3 (2022): 45. http://dx.doi.org/10.3390/vision6030045.

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The aim of the study was to assess various retinal vessel parameters of diabetes mellitus (DM) patients and their correlations with systemic factors in type 2 DM. A retrospective exploratory study in which 21 pairs of baseline and follow-up images of patients affected by DM were randomly chosen from the Sankara Nethralaya–Diabetic Retinopathy Study (SN DREAMS) I and II datasets. Patients’ fundus was photographed, and the diagnosis was made based on Klein classification. Vessel thickness parameters were generated using a web-based retinal vascular analysis platform called VASP. The thickness changes between the baseline and follow-up images were computed and normalized with the actual thicknesses of baseline images. The majority of parameters showed 10~20% changes over time. Vessel width in zone C for the second vein was significantly reduced from baseline to follow-up, which showed positive correlations with systolic blood pressure and serum high-density lipoproteins. Fractal dimension for all vessels in zones B and C and fractal dimension for vein in zones A, B and C showed a minimal increase from baseline to follow-up, which had a linear relationship with diastolic pressure, mean arterial pressure, serum triglycerides (p < 0.05). Lacunarity for all vessels and veins in zones A, B and C showed a minimal decrease from baseline to follow-up which had a negative correlation with pulse pressure and positive correlation with serum triglycerides (p < 0.05). The vessel widths for the first and second arteries significantly increased from baseline to follow-up and had an association with high-density lipoproteins, glycated haemoglobin A1C, serum low-density lipoproteins and total serum cholesterol. The central reflex intensity ratio for the second artery was significantly decreased from baseline to follow-up, and positive correlations were noted with serum triglyceride, serum low-density lipoproteins and total serum cholesterol. The coefficients for branches in zones B and C artery and the junctional exponent deviation for the artery in zone A decreased from baseline to follow-up showed positive correlations with serum triglycerides, serum low-density lipoproteins and total serum cholesterol. Identifying early microvascular changes in diabetic patients will allow for earlier intervention, improve visual outcomes and prevent vision loss.

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Petrik, G. G., and S. A. Pavlishchuk. "Parametry metabolizma i gemostazapri endogennom giperkortitsizme s narusheniemuglevodnogo obmena." Obesity and metabolism 8, no. 3 (2011): 26–29. http://dx.doi.org/10.14341/2071-8713-4833.

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The aim of the study was to determine peculiarities of protein and lipid metabolism as well as platelet-coagulation hemostasis depending on the pathogenesis of the endogenous hypercortisolism and assessment of the impact of chronic hyperglycemia on studied parameters. Materials and methods. The study included 19 patients with pituitary microadenomas with median age of 45,0 (41; 49) years and 9 patients with nodular adrenal gland hyperplasia aged 49,5 (42; 57) years, 14 of whom had diabetes mellitus. Results. Biochemical and coagulation parameters in patients with endogenous hyperpercortisolism regardless of ethiology Cushing`s syndrome differed from the control group in increased concentration of total cholesterol, high-density lipoproteins, low-density lipoproteins, alpha2-globulins and decreased gamma globulins, as well as in increased average volume of platelets and enhanced aggregation properties. Carbohydrate metabolism disorders were not characterized by significant differences in metabolic parameters and platelet hemostasis, but were accompanied by the reduction of APTT.

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Abraini, Jacques H., Guillaume Marassio, Helene N. David, Beatrice Vallone, Thierry Prangé, and Nathalie Colloc’h. "Crystallographic Studies with Xenon and Nitrous Oxide Provide Evidence for Protein-dependent Processes in the Mechanisms of General Anesthesia." Anesthesiology 121, no. 5 (2014): 1018–27. http://dx.doi.org/10.1097/aln.0000000000000435.

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Abstract Background: The mechanisms by which general anesthetics, including xenon and nitrous oxide, act are only beginning to be discovered. However, structural approaches revealed weak but specific protein–gas interactions. Methods: To improve knowledge, we performed x-ray crystallography studies under xenon and nitrous oxide pressure in a series of 10 binding sites within four proteins. Results: Whatever the pressure, we show (1) hydrophobicity of the gas binding sites has a screening effect on xenon and nitrous oxide binding, with a threshold value of 83% beyond which and below which xenon and nitrous oxide, respectively, binds to their sites preferentially compared to each other; (2) xenon and nitrous oxide occupancies are significantly correlated respectively to the product and the ratio of hydrophobicity by volume, indicating that hydrophobicity and volume are binding parameters that complement and oppose each other’s effects; and (3) the ratio of occupancy of xenon to nitrous oxide is significantly correlated to hydrophobicity of their binding sites. Conclusions: These data demonstrate that xenon and nitrous oxide obey different binding mechanisms, a finding that argues against all unitary hypotheses of narcosis and anesthesia, and indicate that the Meyer–Overton rule of a high correlation between anesthetic potency and solubility in lipids of general anesthetics is often overinterpreted. This study provides evidence that the mechanisms of gas binding to proteins and therefore of general anesthesia should be considered as the result of a fully reversible interaction between a drug ligand and a receptor as this occurs in classical pharmacology.

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Tsymbryla, Volodymyr, Liliya Barylyak, Xawery Żukow, and Igor Popovych. "Metabolic accompaniment of plasma lipoproteins profile in persons with maladaptation." Journal of Education, Health and Sport 42, no. 1 (2023): 174–88. http://dx.doi.org/10.12775/jehs.2023.42.01.016.

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Background. During the implementation of the project "The relationship between the lipoprotein profile of the blood plasma and the parameters of the neuroendocrine-immune complex, and the influence of the factors of the Truskavets’ spa on them", we first divided observed cohort into 5 homogeneous groups that differed from each other by 6 discriminant variables. The purpose of this study is to identify the metabolic accompaniment of plasma lipoprotein profile in the same persons. Material and research methods. The object of observation were 41 volunteers: 20 women aged 30-76 years and 21 men aged 24-69 years without clinical diagnose but with dysfunction of neuroendocrine-immune complex and dysmetabolism. We estimated lipoprotein profile of plasma, determined the levels of the proinflammatory cytokines, parameters of lipid peroxidation as well as routine biochemical and paraclinical parameters. Results. The patients with increased, normal and decreased levels of Dobiásová’s&Frohlich’s Atherogenic Index of Plasma (D&FAIP) are characterized, together with levels of Triglycerides and HDLP Cholesterol by definition, by specific constellations of levels of IL-6, IL-1, Diene conjugates, Malondialdehyde, Katalase, Glucose, and Alanine aminotransferase (classification accuracy is 98.8%). A close canonical correlation was found between the parameters of the plasma lipoprotein profile, on the one hand, and metabolism and erythroon, on the other (R=0.920). Conclusion. Atherogenic, normal and anti-atherogenic blood plasma is characterized by specific levels of markers of inflammation, lipid peroxidation, cytolysis and erythroon.

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Kozlova, N. V., E. G. Makarova, and F. I. Nikitin. "Variability of physiological and biochemical parameters of the blood of beluga females (Huso huso) in the conditions of artificial reproduction." Rybovodstvo i rybnoe hozjajstvo (Fish Breeding and Fisheries), no. 12 (December 5, 2022): 817–27. http://dx.doi.org/10.33920/sel-09-2212-04.

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The results of a study and analysis of the physiological and biochemical parameters of the blood of beluga females (Huso huso) during the spawning period were presented in the article. The data were obtained in the laboratory of molecular genetics and physiology of the Volga-Caspian branch of the VNIRO (CaspNIRKH) in the period 2020–2022 during the monitoring of artificial reproduction. We studied females of the V stage of gonads maturity of natural (domesticated stocks) and artificial parameters of blood in beluga females during the spawning period was calculated using descriptive statistics based on parametric and nonparametric criteria. A comparative analysis of females of domesticated stocks and broodstocks revealed an unreliable (p > 0.05) trend of excess of the studied physiological and biochemical parameters in the blood of individuals of artificial generation, with the exception of beta-lipoproteins. The established ranges of blood components characterized the heterogeneity of the functional state of spawners at the spawning stage. There was a positive correlation (p < 0.05) between cholesterol and total lipids (r = +0.56), cholesterol and beta-lipoproteins (r = +0.74), beta-lipoproteins and total lipids (r = +0.44),hemoglobin and total serum protein (r = +0.58). The recorded dynamics testified to a unidirectional regularity in the consumption of fish biochemical components for the formation of reproductive products. The results obtained are necessary to assess the “quality” of beluga spawners in order to optimize the technologies for obtaining physiologically high-grade juveniles under conditions of artificial reproduction.

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Thigula, Jayaprada. "Effect of hormone replacement therapy on biochemical parameters in post-menopausal women." International Journal of Reproduction, Contraception, Obstetrics and Gynecology 6, no. 10 (2017): 4631. http://dx.doi.org/10.18203/2320-1770.ijrcog20174454.

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Background: In females, menopause is a loss of natural events that marks the end of the reproductive years. Menopause its associated complications can be managed by hormone replacement therapy (HRT). This study hypothesized to evaluate the effect of hormone replacement therapy on clinico biochemical levels in postmenopausal women.Methods: A total one hundred postmenopausal females were considered. Based on medication administered patients were divided in to five groups i.e. Premarin group, Ovral-L group, Evalon group, Transdermal E2 Gel group and Control group with oral calcium placebo therapy. A complete Haemogram, ECG, Urine examination, lipid profile were investigated.Results: Most common clinical symptoms is vasomotor/psychological (45% in all groups) related followed by urogenital/psychological symptoms (22% in all groups). The mean lipid lipoproteins before therapy, after 2 months and 6 months follow up showed significant change in all the groups.Conclusions: HRT can be a safe method to manage urogenital complication and vasomotor symptoms in postmenopausal women. It has a notable impact on the lipid profile and lipoproteins which helps to reduce the chances to get associated health complications.

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Bin-Jumah, May Nasser, Muhammad Shahid Nadeem, Sadaf Jamal Gilani, et al. "Lycopene: A Natural Arsenal in the War against Oxidative Stress and Cardiovascular Diseases." Antioxidants 11, no. 2 (2022): 232. http://dx.doi.org/10.3390/antiox11020232.

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Lycopene is a bioactive red pigment found in plants, especially in red fruits and vegetables, including tomato, pink guava, papaya, pink grapefruit, and watermelon. Several research reports have advocated its positive impact on human health and physiology. For humans, lycopene is an essential substance obtained from dietary sources to fulfil the body requirements. The production of reactive oxygen species (ROS) causing oxidative stress and downstream complications include one of the major health concerns worldwide. In recent years, oxidative stress and its counter strategies have attracted biomedical research in order to manage the emerging health issues. Lycopene has been reported to directly interact with ROS, which can help to prevent chronic diseases, including diabetes and neurodegenerative and cardiovascular diseases. In this context, the present review article was written to provide an accumulative account of protective and ameliorative effects of lycopene on coronary artery disease (CAD) and hypertension, which are the leading causes of death worldwide. Lycopene is a potent antioxidant that fights ROS and, subsequently, complications. It reduces blood pressure via inhibiting the angiotensin-converting enzyme and regulating nitrous oxide bioavailability. It plays an important role in lowering of LDL (low-density lipoproteins) and improving HDL (high-density lipoproteins) levels to minimize atherosclerosis, which protects the onset of coronary artery disease and hypertension. Various studies have advocated that lycopene exhibited a combating competence in the treatment of these diseases. Owing to all the antioxidant, anti-diabetic, and anti-hypertensive properties, lycopene provides a potential nutraceutical with a protective and curing ability against coronary artery disease and hypertension.

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Abduljabbar, Nawar Bahaa, Abdulkhaliq Ahmed Farhan Aljanabi, and Mohammed Saleh Mohamed Alslami. "Effect of Different Levels on Some Physiological and Productive Parameters of Local Rabbits in Iraq." IOP Conference Series: Earth and Environmental Science 1371, no. 7 (2024): 072034. http://dx.doi.org/10.1088/1755-1315/1371/7/072034.

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Abstract This study was conducted in the poultry farm located in the Department of Animal Production, Faculty of Agriculture, Tikrit University, during the period from 1 March to 1 April 2023 (30 days), to evaluate the effect of dietary addition of different levels of algae powder (0, 2.4 g/kg concentrate) on productive performance and some physiological traits in rabbits. This experiment used 12 local female rabbits aged 9-10 months with an average body weight of 1563.12 ± 30.08 g. The rabbits were distributed into four treatments: the first (T1) was considered as a control treatment (without addition), the second (T2) and the third (T3) treatments were fed diets with algae powder at levels of 2 and 4 g/kg concentrated feed, respectively. The results indicated that the use of powder (2 and 4 g/kg feed concentrate (T2 and T3) led to a significant (P<0.05) increase in final body weight, packed cell volume (PCV), blood hemoglobin (Hb), and blood counts of red blood cells (RBC), and concentration of total protein, albumin, and high-density lipoproteins (HDL) and a significant (P<0.05) decrease in the number of white blood cells, and concentration of cholesterol, triglycerides, low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), and liver enzymes (AST and ALT) in the blood serum of treated animals as compared to control (T1). In conclusion, dietary supplementation of powder at 2 Or 4 g/kg concentrated feed improved growth performance and healthy status of local female rabbits in Iraq.

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Dushina, T. S., S. M. Klyashev, L. A. Suplotova, E. F. Dorodneva, and M. V. Nikolenko. "Characteristics of intestinal microbiota parameters in young people with metabolic syndrome." Perm Medical Journal 41, no. 3 (2024): 5–14. http://dx.doi.org/10.17816/pmj4135-14.

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Objective. To study the features of the colon microbiota, as well as the associations of microbial representatives with anthropometric, anamnestic and biochemical parameters in young patients with metabolic syndrome. Materials and methods. 118 young people took part in a single-center, one stage, controlled study. 87 of them were diagnosed with obesity, and 31 people with normal body weight formed the control group (“C”). 87 obese patients were divided into 2 groups: “MS-” which consisted of 43 people (49.4%), and “MS+” including 44 people (50.6%) with metabolic syndrome. When stratifying the groups, the NCEP ATP III criteria were used. Blood for biochemical test was taken from all the participants, and the condition of the colon microbiota was assessed using polymerase chain reaction («Colonoflor-16 (premium)»). The Microsoft Excel 2010 and IBM SPSS Statistics 26.0 application software package were used for statistical calculations. The results were evaluated as statistically significant at a level of p0.05. Results. In the MS+ group Fusobacterium nucleatum (Fusobacteriaceae family) was detected statistically significantly more often than in individuals from group “C” (40.5%). Differences in the bacterial composition of the intestinal microbiota between two groups of obese people were revealed: in the “MS+” group there was a significant decrease in bacteria of the genus Bifidobacterium (Bifidobacteriaceae family), Prevotella (Prevotellaceae family) and Faecalibacterium prausnitzii (Ruminococcaceae family) (p0.05). In addition, correlation patterns between the species and generic composition of the microbiota on the one hand and age, BMI, waist circumference, hip circumference, breastfeeding duration, indicators of carbohydrate (glucose, insulin, HOMA-IR index) and lipid (total cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins, high-density lipoproteins) metabolism, CRP on the other hand have been established. Conclusions. The colon microbiota in obese patients is characterized by proinflammatory changes. For the metabolically unhealthy phenotype of obesity these changes are most characteristic. It is clear that further research is needed to determine the mechanisms underlying the influence of bacterial-fungal associations on metabolism in obese individuals, as these mechanisms are likely to play a key role in the development of metabolic diseases.

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Ermeith, Enas, Ashraf Jamal Mahmoud, and Buthaina Jassim Yousef. "The Effect of Infection by Toxocariasis on Some Biochemical Parameters in Some Areas of Salah Al-Din Governorate." Journal of Life and Bio Sciences Research 1, no. 3 (2020): 89–92. http://dx.doi.org/10.38094/jlbsr1329.

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The current study examined 277 blood samples of people, from both sexes of different ages, living in different areas of Salah Al-Din Governorate (Tikrit, Al-Alam and Baiji districts). The study was conducted from November, 2018 to June, 2019. All participants were secrened to investigate the incidence of toxocariasis using IgG TES-ELISA technique. The results showed that the rate of infection with toxocariasis was 22%. It was found an increase in cholesterol concentrations within age group 48-58 years and amounted to 185.8 mg/dl, and highest rate of increase in triglycerides was recorded within age group 15-25 years (168.1 mg/dl). The highest percentage of total protein was recorded within age group 26- 36 years (6.67 mg/dl). As for lipoprotein tests, highest percentage of high-density lipoproteins in age group 48-58 years was recorded (53 mg/dl), while low-density lipoproteins were highest in age group 48-58 years (100.8 mg/dl), and in very low-density lipoproteins the highest percentage within age group 15-25 years (33.5 mg/dl). The highest percentage of AST liver enzymes was recorded in age group 15-25 years and the percentage was 20.6 u/l. The highest percentage of ALT was recorded in age group 26-36 years (20.1 u/l) and 15-25 years (20 u/l). It is concluded that This age group continues to be exposed to infection with toxocariasis, which leads to presence large numbers of live larvae which secrete their antigens in the body and thus spread of toxoplasmosis, and the increase in proportion of fats is caused by poor oxidation of fatty acids and increased production of hepatic fatty acids Which leads to a delay in breakdown of lipoproteins, and the increase in level of AST, ALT enzyme occurs in cases of hepatitis and cirrhosis and may be associated with advanced cases of toxocariasis.

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Khalak, V. I., S. Ye Cherniavs’kiy, and P. T. Chegorka. "PHYSICO-CHEMICAL PROPERTIES OF MUSCLE TISSUE OF YOUNG PIGS AND THEIR RELATIONSHIP WITH CERTAIN BIOCHEMICAL INDICATORS OF BLOOD SERUM." Scientific Journal Grain Crops 4, no. 2 (2020): 372–77. http://dx.doi.org/10.31867/2523-4544/0146.

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The article presents the results of studies of the physicochemical properties of the muscle tissue of young pigs of the large white breed, taking into account their intrabreed differentiation by some biochemical parameters of blood serum, and the correlation links between the signs are determined. The control fattening of young pigs of large white breed was carried out in the conditions of the farm according to the "Methodology for assessing boars and sows for the yield of offspring in the minds of breeding plants and breeding reproducers". In the blood serum of 5-month-old animals, the cholesterol content (mmol/l) and the concentration of total lipoproteins (mg%) were determined. The physicochemical properties of the longest back muscle (m. Longissimus dorsi) were studied taking into account the following indicators: "water-holding capacity, %", "active acidity 24 hours after slaughter (pH), acidity units", "color intensity, units extract х 1000", "tenderness, s "and" losses during heat treatment, %". Biometric processing of the obtained data was carried out according to generally accepted methods using the Data Analysis software module in Microsoft Excel. It was found that the biochemical parameters of blood serum (cholesterol content (mmol/l) and the concentration of total lipoproteins (mg %) in young pigs of the Large White breed correspond to the physiological norm of clinically healthy animals. The number of samples of the longissimus dorsi muscle (m. Longissimus dorsi) of the category "high quality "according to the indicators" tenderness, s "and" water-holding capacity, % "is 9.09 %, according to the" color intensity, units. х 1000" – 18.18 %. Reliable coef-ficients of pair correlation are established between the following pairs of signs: concentration of total lipoproteins х active acidity 24 hours after slaughter (pH) (+0.618), concentration of total lipoproteins х water-holding capacity (+0.712), cholesterol content х tenderness (+0.726), cholesterol content х losses during heat treatment (+0.784). Key words: muscle, tissue, young pigs, blood, biochemical parameters, serum.

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Bashmakova, N. V., А. А. Denisov, T. B. Tretyakova, L. A. Pestryaeva, and A. Yu Semenov. "Molecular Genetic Determinants of Impaired Lipid Metabolism in the Pathogenesis of Preeclampsia." Doctor.Ru 23, no. 8 (2024): 32–40. https://doi.org/10.31550/1727-2378-2024-23-8-32-40.

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Aim. To study the role of lipid metabolism gene polymorphism and changes in the lipid-transporting lipid system in patients with moderate to severe preeclampsia (PE). Design. Prospective cohort comparative study. Materials and methods. We analysed results of clinical, anamnestic and laboratory examination of 130 patients with a high risk of PE, following a prenatal diagnostics performed during the first trimester. The patients were divided into three groups: with actual severe PE (group I, n = 53, weeks 23 to 38 of pregnancy); with actual moderate PE (group II, n = 45, weeks 28 to 40 of pregnancy), and without PE (control group, or group III, n = 32, weeks 28 to 40 of pregnancy). During the clinical examination, somatic and obstetric-gynaecological history was taken, and the present pregnancy was reviewed. A sample for blood biochemistry was drawn upon hospitalisation; the analysis included lipid parameters (cholesterol, triglycerides, high, low and very low-density lipoproteins), total bilirubin, urea, creatinine, apolipoproteins (АроА, АроВ). Sample genotyping was performed using the realtime polymerase chain reaction with a reagent kit and protocol for genetic polymorphisms. Results. The results show that the most informative parameters of dyslipidaemia in pregnant women, which are associated with the risk of PE, are high levels of very low-density lipoproteins, atherogenic index of over 3.5 and ApoB/ApoA index of over 0.9. The presence of allele T of polymorphic locus ApoE rs429358 in homo- or heterozygous state in the genotype increases the risk of PE, while genotype СС of polymorphism ApoE rs429358 has a protective effect against this pathology. Genotype AA of polymorphism rs708272 of gene CETP (G>A) has also a protective effect, while the presence in the genotype of at least one variant of allele G of this locus increases the risk of PE. Conclusion. The study demonstrates the importance of lipid transport system parameters, especially the ratio of apolipoproteins and various density lipoproteins, as well as polymorphisms ApoE T>C, CETP G>A in the pathogenesis and diagnosis of PE. Keywords: preeclampsia, lipid transport system, lipoproteins, polymorphism, AроЕ, CETP.

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Reddy, Rama Manohar I., Pushpa B. Latha, Tartte Vijaya, and Dattatreya S. Rao. "The Saponin-Rich Fraction of a Gymnema sylvestre R. Br. Aqueous Leaf Extract Reduces Cafeteria and High-Fat Diet-Induced Obesity." Zeitschrift für Naturforschung C 67, no. 1-2 (2012): 39–46. http://dx.doi.org/10.1515/znc-2012-1-206.

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We examined the antiobesity effect of a saponin-rich fraction of a Gymnema sylvestre R. Br. aqueous leaf extract (SGE) using cafeteria and high-fat diet-induced obese rats for a period of eight weeks. SGE was orally administered at a dose of 100 mg/kg body weight once a day to the treatment group. It significantly decreased the body weight, food consumption, visceral organs weight, and the levels of triglycerides, total cholesterol, low-density lipoproteins, very low-density lipoproteins, atherogenic index, glucose, and increased the levels of high-density lipoproteins. There was no significant difference with respect to all parameters of the study in case of normal (N) diet and N diet + SGE rats. In vitro, SGE inhibited the pancreatic lipase activity. The present study gave clear evidence that the SGE has a significant antiobese action, supporting its use in traditional medicine, and can be used as a substitute for synthetic drugs.

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Journal articles on the topic 'Nitrous and Lipoproteins parameters'

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