Relevant bibliographies by topics / NK differentiation

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'NK differentiation'

Author: Grafiati
Published: 1 February 2025
Last updated: 31 July 2025

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Journal articles on the topic "NK differentiation"

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Kaur, Kawaljit, Angie Perez Celis та Anahid Jewett. "Natural Killer Cell-Secreted IFN-γ and TNF-α Mediated Differentiation in Lung Stem-like Tumors, Leading to the Susceptibility of the Tumors to Chemotherapeutic Drugs". Cells 14, № 2 (2025): 90. https://doi.org/10.3390/cells14020090.

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We demonstrate that natural killer (NK) cells induce a higher cytotoxicity against lung cancer stem-like cells (hA549) compared to differentiated lung cancer cell lines (H292). The supernatants from split-anergized NK cells (IL-2 and anti-CD16 mAb-treated NK cells) induced differentiation in hA549. Differentiated lung cancer cell line (H292) and NK cells differentiated hA549 expressed reduced NK cell-mediated cytotoxicity but expressed higher sensitivity to chemotherapeutic drugs. This finding validated our previous reports demonstrating that the levels of tumor killing by NK cells and by chem
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Persyn, Eva, Sigrid Wahlen, Laura Kiekens, et al. "TXNIP Promotes Human NK Cell Development but Is Dispensable for NK Cell Functionality." International Journal of Molecular Sciences 23, no. 19 (2022): 11345. http://dx.doi.org/10.3390/ijms231911345.

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The ability of natural killer (NK) cells to kill tumor cells without prior sensitization makes them a rising player in immunotherapy. Increased understanding of the development and functioning of NK cells will improve their clinical utilization. As opposed to murine NK cell development, human NK cell development is still less understood. Here, we studied the role of thioredoxin-interacting protein (TXNIP) in human NK cell differentiation by stable TXNIP knockdown or overexpression in cord blood hematopoietic stem cells, followed by in vitro NK cell differentiation. TXNIP overexpression only ha
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Vargas, Claudia L., Jennifer Poursine-Laurent, Liping Yang, and Wayne M. Yokoyama. "Development of thymic NK cells from double negative 1 thymocyte precursors." Blood 118, no. 13 (2011): 3570–78. http://dx.doi.org/10.1182/blood-2011-06-359679.

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Abstract The differentiation of natural killer (NK) cells and a subpopulation of NK cells which requires an intact thymus, that is, thymic NK cells, is poorly understood. Previous in vitro studies indicate that double negative (CD4−CD8−, DN) thymocytes can develop into cells with NK cell markers, but these cells have not been well characterized. Herein, we generated and characterized NK cells differentiating from thymic DN precursors. Sorted DN1 (CD44+CD25−) CD122−NK1.1− thymocytes from Rag1−/− mice were adoptively transferred into Rag1−/−Ly5.1 congenic mice. After intrathymic injection, donor
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Freud, Aharon G., Akihiko Yokohama, Brian Becknell, et al. "Evidence for discrete stages of human natural killer cell differentiation in vivo." Journal of Experimental Medicine 203, no. 4 (2006): 1033–43. http://dx.doi.org/10.1084/jem.20052507.

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Human natural killer (NK) cells originate from CD34(+) hematopoietic progenitor cells, but the discrete stages of NK cell differentiation in vivo have not been elucidated. We identify and functionally characterize, from human lymph nodes and tonsils, four NK cell developmental intermediates spanning the continuum of differentiation from a CD34(+) NK cell progenitor to a functionally mature NK cell. Analyses of each intermediate stage for CD34, CD117, and CD94 cell surface expression, lineage differentiation potentials, capacity for cytokine production and natural cytotoxicity, and ETS-1, GATA-
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Grzywacz, Bartosz, Nandini Kataria, Niketa Kataria, Bruce R. Blazar, Jeffrey S. Miller, and Michael R. Verneris. "Natural killer–cell differentiation by myeloid progenitors." Blood 117, no. 13 (2011): 3548–58. http://dx.doi.org/10.1182/blood-2010-04-281394.

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Abstract Because lymphoid progenitors can give rise to natural killer (NK) cells, NK ontogeny has been considered to be exclusively lymphoid. Here, we show that rare human CD34+ hematopoietic progenitors develop into NK cells in vitro in the presence of cytokines (interleukin-7, interleukin-15, stem cell factor, and fms-like tyrosine kinase-3 ligand). Adding hydrocortisone and stromal cells greatly increases the frequency of progenitor cells that give rise to NK cells through the recruitment of myeloid precursors, including common myeloid progenitors and granulocytic-monocytic precursors to th
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Vitale, Chiara. "Plasticity of NK-cell differentiation." Blood 117, no. 13 (2011): 3482–83. http://dx.doi.org/10.1182/blood-2011-01-327965.

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Lee, Jiwon, Suk Hyung Lee, Mira Jeong, and Inpyo Choi. "The effects of tumor necrosis factor-alpha on in vitro differentiation of natural killer cells (138.13)." Journal of Immunology 182, no. 1_Supplement (2009): 138.13. http://dx.doi.org/10.4049/jimmunol.182.supp.138.13.

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Abstract Natural killer (NK) cells are differentiated from hematopoietic stem cells (HSCs) in bone marrow. The differentiation of NK cells is regulated by various factors including soluble growth factors and transcription factors. Here, we demonstrated that tumor necrosis factor-α (TNF-α) is a positive regulator of NK cell differentiation. HSC-derived precursor NK (pNK) cells were further differentiated into mature NK (mNK) cells in the presence of IL-15 in vitro. The potential role of TNF-α on NK cell maturation was evaluated in the presence or absence of IL-15. TNF-α itself induced the expre
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Holmes, Tim D., Ram Vinay Pandey, Eric Y. Helm, et al. "The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation." Science Immunology 6, no. 57 (2021): eabc9801. http://dx.doi.org/10.1126/sciimmunol.abc9801.

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Epigenetic landscapes can provide insight into regulation of gene expression and cellular diversity. Here, we examined the transcriptional and epigenetic profiles of seven human blood natural killer (NK) cell populations, including adaptive NK cells. The BCL11B gene, encoding a transcription factor (TF) essential for T cell development and function, was the most extensively regulated, with expression increasing throughout NK cell differentiation. Several Bcl11b-regulated genes associated with T cell signaling were specifically expressed in adaptive NK cell subsets. Regulatory networks revealed
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Sánchez, M. J., M. O. Muench, M. G. Roncarolo, L. L. Lanier, and J. H. Phillips. "Identification of a common T/natural killer cell progenitor in human fetal thymus." Journal of Experimental Medicine 180, no. 2 (1994): 569–76. http://dx.doi.org/10.1084/jem.180.2.569.

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The phenotypic similarities between natural killer (NK) and T cells have led to the hypothesis that these distinctive lymphocyte subsets may be developmentally related and thus may share a common progenitor (Lanier, L. L., H. Spits, and J. H. Phillips, 1992. Immunol. Today. 13:392; Rodewald, H.-R., P. Moingeon, J. L. Lurich, C. Dosiou, P. Lopez, and E. L. Reinherz. 1992. Cell. 69:139). In this report, we have investigated the potential of human CD34+ triple negative thymocytes ([TN] CD3-, CD4-, CD8-) to generate both T cells and NK cells in murine fetal thymic organ cultures (mFTOC) and in vit
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Cavazzana-Calvo, M., S. Hacein-Bey, G. de Saint Basile, et al. "Role of interleukin-2 (IL-2), IL-7, and IL-15 in natural killer cell differentiation from cord blood hematopoietic progenitor cells and from gamma c transduced severe combined immunodeficiency X1 bone marrow cells." Blood 88, no. 10 (1996): 3901–9. http://dx.doi.org/10.1182/blood.v88.10.3901.bloodjournal88103901.

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Natural killer (NK) cells are characterized by their ability to mediate spontaneous cytotoxicity against susceptible tumor cells and infected cells. They differentiate from hematopoietic progenitor cells. Patients with X-linked severe combined immunodeficiency (SCID X1) carry mutations in the gamma c cytokine receptor gene that result in lack of both T and NK cells. To assess the role of interleukin-2 (IL-2), IL-7, and IL-15 cytokines, which share gamma c receptor subunit, in NK cell differentiation, we have studied NK cell differentiation from cord blood CD34 (+) cells in the presence of eith
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Dissertations / Theses on the topic "NK differentiation"

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Jülke, Kerstin. "Role of cytokines for NK cell competence and differentiation." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2010. http://dx.doi.org/10.18452/16216.

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Humane NK Zellen können in CD56br und CD56dim NK Zellen unterteilt werden. In dieser Arbeit wurde untersucht, in welchem Zusammenhang die verschiedenen NK Zell Populationen stehen und wie funktional kompetente NK Zellen generiert werden. Des Weiteren wurde die Heterogenität der CD56dim NK Zell Population in Bezug auf Funktionalität und Differenzierungsstadien analysiert. Es konnte gezeigt werden, dass CD56br NK Zellen in CD56dim NK Zellen differenzieren. Währenddessen werden u.a. MHC-I spezifische inhibierende Rezeptoren (KIR) erworben. Diese sind essentiell für die Unterscheidung zwischen “S
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Farren, Timothy william. "The role of the NK cell receptor CD160 in the diagnosis, differentiation and function of chronic B-cell malignancies." Thesis, Queen Mary, University of London, 2013. http://qmro.qmul.ac.uk/xmlui/handle/123456789/9011.

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Chronic Lymphocytic Leukaemia (CLL) remains the most abundant leukaemia in those aged over 65 years. It is characterised by the expansion of malignant monoclonal B-lymphocytes that were originally described as being functionally incompetent. Identified by immunophenotypic expression of monoclonal light chain restriction, it falls into the classification of chronic B-cell lymphoproliferative disorders (B-LPD). This thesis aims to demonstrate that CD160, an activating NK cell receptor, is aberrantly expressed in B-LPD and can function as a tumour specific antigen, which has clear translation rol
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Huyghe, Matthias. "Approche thérapeutique anticancéreuse par immunothérapie basée sur les cellules NK dérivées de cellules iPS." Electronic Thesis or Diss., université Paris-Saclay, 2024. http://www.theses.fr/2024UPASL104.

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Les cellules Natural Killer (NK) sont des cellules spécialisées dans l'immunosurveillance, capables de reconnaître et de lyser les cellules transformées ou infectées par des virus. En raison de leurs propriétés biologiques spécifiques, le transfert adoptif de cellules NK pour l'immunothérapie contre le cancer représente une alternative prometteuse à l'utilisation des cellules CAR-T chez certains patients. Les cellules souches pluripotentes induites (iPSC) se sont imposées comme une source attractive pour la génération de cellules NK à des fins thérapeutiques. En effet, les iPSC peuvent être fa
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Sohlberg, Ebba. "Immune maturation in early childhood and the influence of herpesvirus infections." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-93034.

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The quality of immune responses develops from birth into adulthood and in the context of the host microbial environment. The aim of this work was to study immune maturation during childhood, and how this process can be affected by the common herpesviruses; Epstein-Barr virus (EBV) and cytomegalovirus (CMV). In paper I we studied monocytes, an important cell type for immunity in the newborn. We showed that the neonatal monocyte subsets exist in similar frequencies as adult subsets, and have a potent capacity for pro-inflammatory cytokine production. In paper II, III and IV we studied the effect
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Corbel, Stéphane. "Mise en évidence d'un transport bi-directionnel d'histamine dans les progéniteurs hématopoïétiques murins." Paris 5, 1997. http://www.theses.fr/1997PA055001.

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L'histamine, un médiateur forme après décarboxylation de l'histidine par une enzyme l'histidine décarboxylase (HDC), est produite par différents types cellulaires du système immunitaire ou nerveux. Sa qualité d'agent immunomodulateur et de neurotransmetteur est clairement démontrée. Son rôle dans les phénomènes de prolifération et différenciation cellulaires est également suggéré par de nombreux faits expérimentaux. L'histamine pourrait aussi être impliquée dans l'hématopoïèse, et quelques arguments sont en faveur de cette possibilité. Ainsi, dans le laboratoire, nous avons montré une producti
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Jülke, Kerstin [Verfasser]. "Role of cytokines for NK cell competence and differentiation / von Kerstin Jülke." 2010. http://d-nb.info/101054361X/34.

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Guilbault, Lorie. "Étude génétique et biologique de la différenciation et de la maturation des cellules NK." Thèse, 2016. http://hdl.handle.net/1866/18350.

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Les cellules Natural Killer (NK), un sous-type de lymphocytes, sont cruciales dans l’immunité innée de par leur cytotoxicité directe envers les tumeurs, les cellules infectées et les cellules stressées. Elles contribuent également à l’orchestration de la réponse immunitaire adaptative de par leur capacité à produire des cytokines immunorégulatrices. Pour développer ces fonctions effectrices, les cellules NK requièrent l’intégration d’une multitude de signaux. De là, les cellules NK matures (mNK) sont considérées comme appartenant à quatre sous-types conséquents et concordants avec la polarisat
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Nogueira, Marta Faro Craveiro. "Thimic Natural Killer cells as mediators of cell competition." Master's thesis, 2020. http://hdl.handle.net/10316/94240.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>As células Natural Killer (NK) são linfócitos granulares do sistema imune inato cuja função é mediada por recetores expressos na sua superfície celular. A interação entre recetores inibitórios e o complexo principal de histocompatibilidade I (MHC-I), expresso em células saudáveis, impede o desencadear de respostas citotóxicas contra as mesmas. Contudo, em células infetadas ou que sofram transformações, a expressão de MHC-I diminui, despoletando citotoxicidade mediada por células NK. Convencionalmente, a di
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Diaz, Rodriguez Yildian. "La différentiation in vitro des cellules dendritiques plasmacyto des partir de cellules CD34+ de sang de cordon, un outil thérapeutique pour augmenter l'activité́ antitumorale des cellules NK." Thèse, 2017. http://hdl.handle.net/1866/19443.

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L’immunothérapie basée dans l’utilisation des cellules NK pour le traitement de différents types de cancers humains est une stratégie très prometteuse. Les cellules dendritiques plasmacytoïdes (pDC) activées permettent de stimuler les cellules NK pour augmenter leurs propriétés anti-tumorales. Les cellules NK activées par les pDC sont capables de développer in vitro et in vivo une forte réponse cytotoxique contre différentes lignées de leucémie lymphoblastiques pre-B. En revanche, les faibles quantités de pDC obtenues à partir du sang périphérique limitent leur l’utilisation en clinique. L’exp
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"Differentiating intercellular interactions that induce cytotoxic activity and cytokine release by NK cells." UNIVERSITY OF MARYLAND, BALTIMORE, 2008. http://pqdtopen.proquest.com/#viewpdf?dispub=3310393.

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Books on the topic "NK differentiation"

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Cerhan, James R., Claire M. Vajdic, and John J. Spinelli. The Non-Hodgkin Lymphomas. Oxford University Press, 2017. http://dx.doi.org/10.1093/oso/9780190238667.003.0040.

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The non-Hodgkin lymphomas (NHL) are a heterogeneous group of over forty lymphoid neoplasms that have undergone a major redefinition over the last twenty-five years, in part due to advances in immunology and genetics as well as implementation of the WHO classification system. NHLs are considered clonal tumors of B-cells, T-cells, or natural killer (NK) cells arrested at various stages of differentiation, regardless of whether they present in the blood (lymphoid leukemia) or lymphoid tissues (lymphoma). In the United States, the age-standardized NHL incidence rate (per 100,000) doubled from 1973
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Book chapters on the topic "NK differentiation"

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Huntington, Nicholas D., Jean-Jacques Mention, Christian Vosshenrich, Naoko Satoh-Takayama, and James P. Di Santo. "Dissecting Human NK Cell Development and Differentiation." In Natural Killer Cells. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-02309-5_2.

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Male, Victoria, and Hugh J. M. Brady. "Transcriptional Control of NK Cell Differentiation and Function." In Transcriptional Control of Lineage Differentiation in Immune Cells. Springer International Publishing, 2014. http://dx.doi.org/10.1007/82_2014_376.

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Wałajtys-Rode, Elżbieta, and Jolanta M. Dzik. "Monocyte/Macrophage: NK Cell Cooperation—Old Tools for New Functions." In Results and Problems in Cell Differentiation. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-54090-0_5.

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Sakuishi, Kaori, Sachiko Miyake, and Takashi Yamamura. "Role of NK Cells and Invariant NKT Cells in Multiple Sclerosis." In Results and Problems in Cell Differentiation. Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/400_2009_11.

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Sivakumar, P. V., I. Puzanov, N. S. Williams, M. Bennett, and V. Kumar. "Ontogeny and Differentiation of Murine Natural Killer Cells and Their Receptors." In Specificity, Function, and Development of NK Cells. Springer Berlin Heidelberg, 1998. http://dx.doi.org/10.1007/978-3-642-46859-9_11.

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Keever, C. A., M. V. Gazzola, K. Pekle, J. H. Bourhis, and A. Gillio. "Regulatory Effect of Recombinant Cytokines on NK Cell Differentiation from Early Marrow Precursors." In Cytokines in Hemopoiesis, Oncology, and AIDS. Springer Berlin Heidelberg, 1990. http://dx.doi.org/10.1007/978-3-642-75510-1_32.

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Riccardi, Carlo, Graziella Migliorati, Antonio Giampietri, Lorenza Cannarile, Emira Ayroldi, and Luigi Frati. "In vivo treatment with recombinant interleukin-2 (IL-2) stimulates the differentiation of natural killer (NK) precursor cells." In The Role of Pharmacology in Pediatric Oncology. Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-4267-7_24.

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Lowe, Emily, Laurel C. Truscott, and Satiro N. De Oliveira. "In Vitro Generation of Human NK Cells Expressing Chimeric Antigen Receptor Through Differentiation of Gene-Modified Hematopoietic Stem Cells." In Natural Killer Cells. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3684-7_20.

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Tonini, Gian Paolo. "Antineoplastic drugs modulating c-myc expression in K562, induce erythroid differentiation and modify, with IFN, susceptibility to NK cell mediated lysis." In The Role of Pharmacology in Pediatric Oncology. Springer Netherlands, 1987. http://dx.doi.org/10.1007/978-94-009-4267-7_23.

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"Fibronectin Expression by Endogenous and Activated NK Cells." In Lymphocyte Activation and Differentiation. De Gruyter, 1988. http://dx.doi.org/10.1515/9783110850253-072.

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Conference papers on the topic "NK differentiation"

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Giraud, J., D. Chalopin, E. Ramel, et al. "P02.07 Innate immunity atlas of hepatocellular carcinoma unravels the differentiation hierarchy of myeloid NK cells and MDSCs." In iTOC9 – 9th Immunotherapy of Cancer Conference, September 22–24, 2022 – Munich, Germany. BMJ Publishing Group Ltd, 2022. http://dx.doi.org/10.1136/jitc-2022-itoc9.26.

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Zhang, Sen, Hongbing Pu, Boqian Wang, et al. "Implementation of a Newton−Krylov Algorithm in the Open-source Solver of PHengLEI." In GPPS Hong Kong24. GPPS, 2023. http://dx.doi.org/10.33737/gpps23-tc-124.

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This paper presents the implementation of a Newton–Krylov (NK) algorithm in the open-source solver of Platform for Hybrid ENGineering simulation of flows (PHengLEI). The linearized equation system is solved using the Generalized Minimal Residual Method (GMRES). The elements of the exact Jacobian matrix are first computed using the automatic differentiation tool of Sacado and then manually assembled. In this work, two solution strategies are investigated for the solution of the RANS equations and the turbulence model equation: a decoupled approach and a coupled approach. The decoupled approach
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Good, Charly R., Shunichiro Kuramitsu, Parisa Samareh, et al. "Abstract 60: Induction of T cell dysfunction and NK-like T cell differentiation in vitro and in patients after CAR T cell treatment." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-60.

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Kennedy, Philippa R., Quinlan M. Kile, Rhett L. Waller, et al. "365 Oxygen levels found in bone marrow (5%) provide an optimal niche for the differentiation of induced-pluripotent stem cell-derived NK cells for the treatment of AML." In SITC 38th Annual Meeting (SITC 2023) Abstracts. BMJ Publishing Group Ltd, 2023. http://dx.doi.org/10.1136/jitc-2023-sitc2023.0365.

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