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Journal articles on the topic "NKC"
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Couture, Réjean, Pierre Picard, Philippe Poulat, and Alexandre Prat. "Characterization of the tachykinin receptors involved in spinal and supraspinal cardiovascular regulation." Canadian Journal of Physiology and Pharmacology 73, no. 7 (1995): 892–902. http://dx.doi.org/10.1139/y95-123.
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The pharmacological characterization of the tachykinin receptors involved in spinal and supraspinal cardiovascular regulation is reviewed in this report. In conscious rats, substance P (SP), neurokinin A (NKA), neurokinin B (NKB), neuropeptide K (NPK), and neuropeptide γ (NPγ) were injected either intrathecally (i.t.) or intracerebroventricularly (i.c.v.), and their effects were assessed on mean arterial blood pressure (MAP) and heart rate (HR). Moreover, selective antagonists for NK1 ((±)-CP-96345 and RP-67580), NK2 (SR-48968), and NK3 (R-486) receptors were tested against the agonists. I.t. tachykinins elicited dose-dependent increases in MAP and HR (NPK > NPγ > SP > NKA > NKB). The cardiovascular response to i.t. SP, NPK, and NPγ was significantly attenuated by the prior i.t. administration of (±)-CP-96345 and RP-67580 but not by SR-48968 and R-486. By the i.c.v. route, tachykinins also elicited pressor and tachycardiac responses dose dependently (NPK > NPγ > SP > NKA > NKB). Senktide and [MePhe7]NKB, two NK3-selective agonists, were slightly more potent than NKB on both parameters. Whereas the cardiovascular response to NPK was largely blocked by (±)-CP-96345 and RP-67580, that to SP was reduced by 40–50%. This treatment had no effect on the cardiovascular response to NKA and [MePhe7]NKB. Conversely, SR-48968 reduced by 40–50% the NKA-induced cardiovascular changes without affecting the central mediated effects of NPK, SP, and [MePhe7]NKB. However, when coadministered, RP-67580 and SR-48968 abolished the effects to SP and NKA while leaving untouched those induced by [MePhe7]NKB. Finally, the central effects mediated by [MePhe7]NKB, senktide, and NKB were blocked by R-486. These findings suggest that the i.t. action of tachykinins on the rat cardiovascular system is mediated by a NK1 receptor in the spinal cord, while NK1, NK2, and NK3 receptors are likely involved in the supraspinal (hypothalamus) effects of these neuropeptides. It is also concluded that NPK is a pure and powerful NK1 agonist, in contrast to SP and NKA, which are not selective for NK1 or NK2 receptors, respectively.Key words: tachykinins, spinal cord, central cardiovascular control, tachykinin receptor antagonists.
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Phương, Đỗ Thị Mỹ. "Người kể chuyện trong truyện truyền kì trung đại Việt Nam". Tạp chí Khoa học 15, № 2 (2019): 25. http://dx.doi.org/10.54607/hcmue.js.15.2.153(2018).
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Bài viết tìm hiểu sự vận động của truyện truyền kì trung đại Việt Nam thông qua các mẫu hình người kể chuyện (NKC). Từ NKC - nhân vật đến NKC - nhân chứng, từ NKC toàn tri không giới hạn đến NKC toàn tri hạn định, từ NKC ẩn danh, giấu mặt đến NKC bộc lộ xúc cảm là những biến chuyển rõ nét trong mô thức trần thuật của truyện truyền kì từ giữa thế kỉ XVIII trở về trước và truyện truyền kì từ giữa thế kỉ XVIII trở về sau.
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Gimeno, Lourdes, Helios Martínez-Banaclocha, M. Bernardo, et al. "NKG2D Polymorphism in Melanoma Patients from Southeastern Spain." Cancers 11, no. 4 (2019): 438. http://dx.doi.org/10.3390/cancers11040438.
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Background: Natural killer (NK) and CD8+ T cells are involved in the immune response against melanoma. C-Type lectin-like NK cell receptors are located in the Natural Killer Complex (NKC) region 12p13.2-p12.3 and play a critical role in regulating the activity of NK and CD8+ T cells. An association between polymorphisms in the NKC region, including the NKG2D gene and NKG2A promoter, and the risk of cancer has been previously described. The aim of this study was to analyze the association of polymorphisms in the NKC region with cutaneous melanoma in patients from southeastern Spain. Methods: Seven single-nucleotide polymorphisms (SNPs) in the NKG2D gene (NKC3,4,7,9,10,11,12), and one SNP in the NKG2A promoter (NKC17) were genotyped by a TaqMan 5′ Nuclease Assay in 233 melanoma patients and 200 matched healthy controls. Results: A linkage disequilibrium analysis of the SNPs performed in the NKC region revealed two blocks of haplotypes (Hb-1 and Hb-2) with 14 and seven different haplotype subtypes, respectively. The third most frequent haplotype from the block Hb-2—NK3 (CAT haplotype)—was significantly more frequent on melanoma patients than on healthy controls (p = 0.00009, Pc = 0.0006). No further associations were found when NKC SNPs were considered independently. Conclusions: Our results suggest an association between NKG2D polymorphisms and the risk of cutaneous malignant melanoma.
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Hansen, Diana S., Krystal J. Evans, Marthe C. D'Ombrain, et al. "The Natural Killer Complex Regulates Severe Malarial Pathogenesis and Influences Acquired Immune Responses to Plasmodium berghei ANKA." Infection and Immunity 73, no. 4 (2005): 2288–97. http://dx.doi.org/10.1128/iai.73.4.2288-2297.2005.
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ABSTRACT The natural killer complex (NKC) is a genetic region of highly linked genes encoding several receptors involved in the control of NK cell function. The NKC is highly polymorphic, and allelic variability of various NKC loci has been demonstrated in inbred mice. Making use of BALB.B6-Cmv1r congenic mice, in which the NKC from disease-susceptible C57BL/6 mice has been introduced into the disease-resistant BALB/c background, we show here that during murine malaria infection, the NKC regulates a range of pathophysiological syndromes such as cerebral malaria, pulmonary edema, and severe anemia, which contribute to morbidity and mortality in human malaria. Parasitemia levels were not affected by the NKC genotype, indicating that control of malarial fatalities by the NKC cells does not operate through effects on parasite growth rate. Parasite-specific antibody responses and the proinflammatory gene transcription profile, as well as the TH1/TH2 balance, also appeared to be influenced by NKC genotype, providing evidence that this region, known to control innate immune responses via NK and/or NK T-cell activation, can also significantly regulate acquired immunity to infection. To date, NKC-encoded innate system receptors have been shown mainly to regulate viral infections. Our data provide evidence for critical NKC involvement in the broad immunological responses to a protozoan parasite.
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Hwang, Young Eun, Seonghun Im, Ju Hyun Cho, et al. "Semi-Biosynthetic Production of Surface-Binding Adhesive Antimicrobial Peptides Using Intein-Mediated Protein Ligation." International Journal of Molecular Sciences 23, no. 23 (2022): 15202. http://dx.doi.org/10.3390/ijms232315202.
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Microbial infections remain a global health concern, calling for the urgent need to implement effective prevention measures. Antimicrobial peptides (AMPs) have been extensively studied as potential antimicrobial coating agents. However, an efficient and economical method for AMP production is lacking. Here, we synthesized the direct coating adhesive AMP, NKC-DOPA5, composed of NKC, a potent AMP, and repeats of the adhesive amino acid 3,4-dihydroxyphenylalanine (DOPA) via an intein-mediated protein ligation strategy. NKC was expressed as a soluble fusion protein His-NKC-GyrA (HNG) in Escherichia coli, comprising an N-terminal 6× His-tag and a C-terminal Mxe GyrA intein. The HNG protein was efficiently produced in a 500-L fermenter, with a titer of 1.63 g/L. The NKC-thioester was released from the purified HNG fusion protein by thiol attack and subsequently ligated with chemically synthesized Cys-DOPA5. The ligated peptide His-NKC-Cys-DOPA5 was obtained at a yield of 88.7%. The purified His-NKC-Cys-DOPA5 possessed surface-binding and antimicrobial properties identical to those of the peptide obtained via solid-phase peptide synthesis. His-NKC-Cys-DOPA5 can be applied as a practical and functional antimicrobial coating to various materials, such as medical devices and home appliances.
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Maneechot, Sutjai, та Nisa Netinatsunton. "ความพึงพอใจของผู้รับบริการต่อการให้บริการการส่องกล้องของสถาบันโรคระบบทางเดินอาหารและตับ นันทนา-เกรียงไกร โชติวัฒนะพันธุ์ (NKC) โรงพยาบาลสงขลานครินทร์". PSU Medical Journal 5, № 1 (2025): 11–19. https://doi.org/10.31584/psumj.2025272974.
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การวิจัยนี้มีวัตถุประสงค์เพื่อศึกษา 1) ระดับความพึงพอใจของผู้รับบริการต่อบริการการส่องกล้องของสถาบัน NKC 2) ปัจจัยที่มีความสัมพันธ์กับความพึงพอใจของผู้รับบริการ วิธีการเก็บข้อมูลโดยใช้แบบสอบถามผ่าน QR Code คัดเลือกกลุ่มตัวอย่างแบบเจาะจง (Purposive sampling) คือผู้ป่วยที่มารับบริการการส่องกล้อง ระยะเวลา 4 เดือน (1 มกราคม - 30 พฤษภาคม 2567) มาตราส่วนความพึงพอใจ แบ่งเป็น 5 ระดับ น้อยที่สุดไปมากที่สุด ผลการวิจัยพบว่า กลุ่มตัวอย่างจำนวน 1,177 คน เป็นเพศชาย ร้อยละ 38.5 และเพศหญิง ร้อยละ 61.5 โดยมีอายุเฉลี่ย = 47 ปี และ S.D.=13.91 ระดับความพึงพอใจของผู้รับบริการในภาพรวมต่อการให้บริการการส่องกล้องของสถาบัน NKC ร้อยละ 97.3 ความพึงพอใจของผู้รับบริการอยู่ในระดับมากที่สุดในทุกหัวข้อ ผู้รับบริการพึงพอใจต่อ ขั้นตอนการบริการเข้าใจง่าย ไม่ยุ่งยาก ซับซ้อนร้อยละ 97.2 ต่อการให้บริการของ บุคลากรที่ให้บริการร้อยละ 98.4 ต่อความสะอาดของสถานที่ให้บริการโดยรวม ร้อยละ 98.5 และปัจจัยที่มีความสัมพันธ์กับความพึงพอใจ โดยคะแนนเฉลี่ยความพึงพอใจสูงสุดอยู่ในกลุ่ม อายุมากกว่า 60 ปี รองลงมาคือ กลุ่มอายุ 31 - 40 ปี ผู้ที่มีความพึงพอใจสูงมีโอกาสจะแนะนำญาติ หรือคนรู้จักมาใช้บริการที่สถาบัน NKC ร้อยละ 95.2 สรุป ระดับความพึงพอใจของผู้รับบริการต่อการให้บริการการส่องกล้องของสถาบัน NKC อยู่ในระดับมากที่สุด ในทุกหัวข้อ และผู้รับบริการส่วนใหญ่จะแนะนำให้ญาติหรือคนที่รู้จักมาใช้บริการ ปัจจัยที่มีความสัมพันธ์กับระดับความพึงพอใจคือกลุ่มอายุ
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Medel, Maria L. H., Gabriela G. Reyes, Luz M. Porras, et al. "Prolactin Induces IL-2 Associated TRAIL Expression on Natural Killer Cells from Chronic Hepatitis C PatientsIn vivoandIn vitro." Endocrine, Metabolic & Immune Disorders - Drug Targets 19, no. 7 (2019): 975–84. http://dx.doi.org/10.2174/1871530319666181206125545.
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Background:Natural killer cells (NKC) are a major component of the innate immune response to HCV, mediating their effects through TRAIL and IFN-γ. However, their function is diminished in chronic HCV patients (HCVp). Prolactin is an immunomodulatory hormone capable of activating NKC.Objective:The study aims to explore if hyperprolactinemia can activate NKC in HCVp.Methods:We treated twelve chronic HCVp (confidence level =95%, power =80%) for 15 days with Levosulpiride plus Cimetidine to induce mild hyperprolactinemia. Before and after treatment, we determined TRAIL and NKG2D expression on peripheral blood NKC, along with cytokine profiles, viral loads and liver function. We also evaluated in vitro effects of prolactin and/or IL-2 on NKC TRAIL or NKG2D expression and IFN-γ levels on cultured blood mononuclear cells from 8 HCVp and 7 healthy controls.Results:The treatment induced mild hyperprolactinemia and increased TRAIL expression on NKC as well as the secretion of IL-1ra, IL-2, PDGF and IFN-γ. Viral loads decreased in six HCVp. IL-2 and TRAIL together explained the viral load decrease. In vitro, prolactin plus IL-2 synergized to increase TRAIL and NKG2D expression on NKC from HCVp but not in controls.Conclusion:Levosulpiride/Cimetidine treatment induced mild hyperprolactinaemia that was associated with NKC activation and Th1-type cytokine profile. Also, an increase in TRAIL and IL-2 was associated with viral load decrease. This treatment could potentially be used to reactivate NKC in HCVp.
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Dons’koi, Boris, Oksana Onyshchuk, Iryna Kononenko, et al. "Accentuated Peripheral Blood NK Cytotoxicity Forms an Unfavorable Background for Embryo Implantation and Gestation." Diagnostics 12, no. 4 (2022): 908. http://dx.doi.org/10.3390/diagnostics12040908.
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Problem Many studies have demonstrated the negative impact of high rates of NK cytotoxicity (NKc) on reproductive processes, but there is no agreement as to the appropriateness and feasibility of using the NKc for routine diagnostic in IVF patients. This study conducted a retrospective analysis of embryo transfer (ET) success rates and live birth rates (LBR) in patients with different NKc values. Method of study 1854 cycles of ET were selected and divided into three groups according to NKc levels, and randomized by anamnesis and age: normal (nNKc, n = 871), elevated (eNKc, n = 759), and reduced NKc (rNKc, n = 123). ET with donors’ embryos (n = 101) were analyzed separately. NKc-to-K562 was measured in PBMC (peripheral blood mononuclear cells) by flow cytometry before ET. The patients did not obtain any additional treatments. Results Patients with eNKc, in addition to having reduced clinical pregnancy rates (OR1.59, p < 0.0001), had increased levels of subsequent pregnancy failures (OR2.545, p < 0.0001) when compared to nNKc patients. As a result, patients with eNKc had almost half the LBR than patients with nNKc (OR2.2, p < 0.0001). In patients with rNKc, LBR was also lowered. eNKc was equally unfavorable for implantation and delivery in cryo- or fresh cycles. Markedly, eNKc was much more unfavorable for reproduction than slightly elevated NKc. The donor’s embryos were implanted irrespective of the recipient’s NKc levels, but the later stages of pregnancy were worse in patients with eNKc. Conclusions Our findings highlighted the negative impact of high levels of NK cytotoxicity on pregnancy outcomes.
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Syamsiro, Mochamad, Nurcaya Putra Anwar, Siti Rochmah Ika, Agus Mulyono, Feri Febria Laksana, and Fadmi Rina. "Rancang Bangun dan Uji Eksperimental Performa Burner Biomassa Berbahan Bakar Limbah Nyamplung (Calophyllum Inophyllum) dan Pelet Kayu." JURNAL SAINS TEKNOLOGI & LINGKUNGAN 11, no. 1 (2025): 1–12. https://doi.org/10.29303/jstl.v11i1.702.
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As a tropical country, Indonesia has abundant biomass potential because plants grow all year. Among the several types of biomass, nyamplung kernel cake (NKC) has a high potential for use as an energy source. The goal of this research was to develop a biomass burner and evaluate its performance using NKC and wood pellets (WP) as comparisons. The burner performance test is designed to investigate the effect of air mass flow rate on combustion flame, heat release rate, and thermal efficiency for both types of biomass. The thermal efficiency of the burner was calculated using the water boiling test (WBT). The results revealed that using NKC resulted in a longer combustion flame at air flow rates of 146 and 219 g/s. The higher the air flow rate, the longer the flame. The combustion of NKC and WP produced the longest flame, measuring 80 cm with an air mass flow rate of 290 g/s. The experiment also demonstrated that WP produced a higher temperature than NKC. The highest combustion temperature was produced by WP, reaching 818.1°C with an air mass flow rate of 290 g/s. From the two types of biomass evaluated, WP combustion produced more heat than NKC. The highest heat release rate of 35.46 kW was achieved with an air mass flow rate of 290 g/s. The burning of NKC resulted in the maximum thermal efficiency, 30.35% at an air mass flow rate of 219 g/.
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Ellis, James L. "Neurokinin receptors subserving bronchoconstriction." Canadian Journal of Physiology and Pharmacology 73, no. 7 (1995): 923–26. http://dx.doi.org/10.1139/y95-127.
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Tachykinin receptor subtypes were initially defined using agonist potency ratios for the endogenous ligands substance P (SP), neurokinin (NK) A, and NKB. On this basis it was suggested that there are three tachykinin receptor subtypes. These subtypes were designated NK1, NK2, and NK3, where SP is most potent at NK1 receptors, NKA is most potent at NK2 receptors, and NKB is most potent at NK3 receptors. Recently analogs of the endogenous ligands that show greater selectivity (about 1000-fold) for the different receptor subtypes have been developed. In addition selective antagonists, which are either nonpeptides or modified peptides, for the receptor subtypes have been developed. This minireview concentrates on the wealth of new knowledge concerning the tachykinin receptor subtypes subserving bronchoconstriction in several mammalian species, including man, provided by the use of these selective agonists and antagonists.Key words: neurokinins, bronchoconstriction, substance P, neurokinin A, receptor subtypes.
Dissertations / Theses on the topic "NKC"
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Desrosiers, Marie-Pierre. "Genetic interaction between H2 and NKC receptor genes confers innate resistance to cytomegalovirus infection." Thesis, McGill University, 2005. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82222.
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In mice, H2 and Ly49h genes determine natural resistance to cytomegalovirus infection by alternate mechanisms. We are interested in MA/My, an inbred strain that is resistant to MCMV infection despite the absence of Ly49H receptor and the presence of a haplotype highly related to the MCMV-susceptible strains 129 and FVB/N. Therefore, it is interesting to study its genetic basis of resistance to MCMV infection. In this study, we have identified Cmv1rm, a new resistance allele conferring resistance in MA/My. We have demonstrated by statistical analyses that both H2 and NKC genes are important and that their genetic interaction is necessary to confer resistance in MA/My. By the characterization of the Ly49 gene repertoire of MA/My, we identified 3 potential activating Ly49 gene candidates. Finally, we have confirmed the presence of an important additive effect of H2 and NKC in a FVB/N x BALB.K cross, indicating that Cmv1 rm resistance mechanism may be present in other inbred strains.
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加藤, 正浩, та 隆也 有田. "心の理論の進化に関するNKC適応度地形に基づく検討". 情報処理学会, 2005. http://hdl.handle.net/2237/10617.
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GADEAU, STEPHANE. "Conception et synthese de nouvelles molecules ligands mixtes des recepteurs nk1 et nk2 (doctorat : pharmacochimie)." Lille 2, 1998. http://www.theses.fr/1998LIL2P258.
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Silva, Valéria Gonçalves da. "Protocolo de cuidados de enfermagem para crianças com cardiopatias congênitas: uma proposta baseada em NANDA-NOC-NIC." Universidade Federal Fluminense, 2012. https://app.uff.br/riuff/handle/1/1446.
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Previous issue date: 2012<br>Conselho Regional de Enfermagem - Rio de Janeiro - COREN-RJ<br>Mestrado Profissional em Enfermagem Assistencial<br>Introdução: O conhecimento dos principais diagnósticos de enfermagem de crianças com cardiopatia congênita hospitalizadas contribui para prever os cuidados de enfermagem a essa clientela. Objetivos: Caracterizar as crianças com cardiopatias congênitas com relação a sexo, idade, comorbidades, tempo de internação e termos registrados nos prontuários pela equipe de enfermagem; identificar os diagnósticos de enfermagem Nanda I, a partir dos termos encontrados nos registros de enfermagem de crianças com cardiopatias congênitas; verificar o grau de concordância da avaliação dos peritos em relação aos diagnósticos de enfermagem identificados; selecionar os resultados e intervenções de enfermagem para estes diagnósticos e analisar os dados encontrados sob a ótica da construção de um protocolo de cuidados de enfermagem com linguagem padronizada. Método: Trata-se de um estudo observacional, transversal com utilização da ferramenta metodológica mapeamento cruzado para identificação da classificação dos diagnósticos de enfermagem. Para a coleta de dados, foi utilizado um formulário preenchido a partir dos registros de enfermagem de 82 prontuários de crianças com cardiopatia congênita hospitalizadas. Os termos foram extraídos na íntegra, comparados com a classificação de diagnósticos de enfermagem pela pesquisadora e posteriormente avaliado por peritos. Os dados dos formulários foram digitados em computador residencial e armazenados em forma de banco de dados utilizando os programas Microsoft Excel 2007. A análise descritiva trouxe distribuições de frequências, cálculo das estatísticas mínimo, máximo, média, desvio padrão e percentis. Resultados: Os diagnósticos de enfermagem que compuseram o protocolo, após a análise de concordância entre peritos em ordem de maior frequência foram: risco de infecção (81,7%); troca de gases prejudicada (46,3%); intolerância à atividade (36,6%); padrão respiratório ineficaz (26,8%); risco de intolerância à atividade (20,7%); débito cardíaco diminuído (19,5%); risco de queda (18,3%); perfusão tissular periférica ineficaz (18,3%); atraso no crescimento e desenvolvimento (17,1%); comportamento desorganizado do lactente (17,1%) e risco de tensão do papel do cuidador (13,4%). Conclusão: Conclui-se, que através do método de mapeamento cruzado de uma linguagem não padronizada com uma linguagem padronizada foi possível identificar os diagnósticos de enfermagem de crianças com cardiopatias congênitas mais prevalentes. E a implementação desse instrumento viabilizará a padronização dos cuidados de enfermagem em uma classificação internacionalmente conhecida, otimização e melhora da qualidade da assistência<br>Background: The knowledge of the main nursing diagnoses of hospitalized children with congenital cardiopathy contributes to forecast the nursing care to this clientele. Objectives: To characterize the children with congenital cardiopathy in relation to gender, age, co morbidities, time of hospitalization and terms registered in the patients records by the nursing team; identify the Nanda I nursing diagnosis from the terms found in the nursing registers of children with congenital cardiopathies; to verify the degree of agreement of the experts evaluation in relation to nursing diagnosis identified; to select the results and nursing interventions for these diagnoses and to analyze data found under the view of the construction of a protocol of nursing care with standardized language. Method: This is an observational, transversal study using a methodological tool cross-mapping for identifying the nursing diagnosis classification. To the data collect, it was used a formulary filled from the nursing records of 82 medical records of hospitalized children with congenital heart disease. The terms were extracted in full, compared with the classification of nursing diagnoses by the researcher and further evaluated by experts. The data were entered into the forms home computer and stored in the form of database programs using Microsoft Excel 2007. The descriptive analysis brought distributions of frequencies, calculation of minimum, maximum, average, standard deviation and percentiles statistics. Results: The nursing diagnoses that comprised the protocol, after the analysis of agreement among experts in order of more frequency were: risk of infection (81.7%); impaired gas exchange (46.3%); activity intolerance (36.6%); ineffective breathing pattern (26.8%); risk of activity intolerance (20.7%); decreased cardiac output (19.5%); risk of falls (18.3%); ineffective peripheral tissue perfusion (18.3%); growth developmental delay (17.1%); disorganized infant behavior (17.1%) and risk of the caregiver tension paper (13.4%). Conclusion: It concludes that through the cross-mapping method of a non- standardized language with a standardized language it was identified the nursing diagnoses of children with most prevalent congenital cardiopathies. And the implementation of this tool will allow the standardization of the nursing care in an internationally known, optimization and improvement of quality of assistance
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Park, Hye Jin. "NANDA-I, NOC, and NIC linkages in nursing care plans for hospitalized patients with congestive heart failure." Diss., University of Iowa, 2010. https://ir.uiowa.edu/etd/570.
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The purpose of the study was to identify NANDA-I, NOC, and NIC linkages based on a clinical reasoning model to capture accurate nursing care plans for patients with Congestive Heart Failure. A retrospective descriptive design was used to address the research questions. Data were obtained from the records of patients discharged for one year with the medical diagnoses of CHF (DRG 127) from an Iowa community hospital. A total of 272 inpatient records were analyzed to describe the frequency and percentage of NANDA-I diagnosis, NIC interventions, and NOC outcomes for patients with CHF. The top ten NANDA-I diagnoses associated with NOC outcomes and NIC interventions were identified. The results were compared with published NNN linkages. Knowledge Deficit (NANDA- I) -Knowledge: Treatment Regimen (NOC)-Teaching Procedure/Treatment (NIC) (N=94) and Cardiac Output Alteration (NANDA-I) - Cardiac Pump Effectiveness (NOC)-Cardiac Care (NIC) (N=83) were the top two NNN linkages for CHF. In addition, using means, SD, and t-tests, the effectiveness of NIC interventions was examined by comparing admission and discharge NOC scores. The top ten NOC outcomes scores showed significant differences between mean score on admission and discharge (p value < .0001). All of top ten NOC-NIC linkages showed significant results in terms of effectiveness (p value
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Argenta, Carla. "Modelo multidimensional de cuidado ao idoso associado aos sistemas de linguagens padronizadas de enfermagem NANDA-I, NIC E NOC." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2018. http://hdl.handle.net/10183/186134.
Full textAbstract:
O cuidado integral ao idoso pode ser garantido mediante a utilização do Processo de Enfermagem (PE), aliado a um referencial teórico como, por exemplo, o Modelo Multidimensional de Envelhecimento bem Sucedido (MMES), que possui uma proposta de avaliação do idoso. Há, contudo, uma lacuna para a sua utilização, uma vez que não há estudos que comprovem a sua eficácia na prática clínica da Enfermagem associado à aplicação de sistemas de classificação da disciplina como a NANDA-I, NIC e NOC. O objetivo deste estudo é construir um modelo multidimensional de cuidado ao idoso associado aos Sistemas de Linguagens Padronizadas de Enfermagem NANDA-I, NIC e NOC, aplicável à consulta de enfermagem. O estudo foi conduzido em duas etapas metodológicas distintas. A primeira compreendeu um estudo de validação de conteúdo enquanto a segunda uma pesquisa de resultados, que contemplou um estudo quase experimental. As amostras foram constituídas de 15 especialistas em Enfermagem Gerontológica e 28 idosos em primeira consulta na Cidade do Idoso, local do estudo, com idade igual ou superior a 60 anos, que apresentaram o diagnóstico de enfermagem Risco de Síndrome do Idoso Frágil (RSIF) ou Síndrome do Idoso Frágil (SIF), no período de maio a outubro de 2017. Após a validação do conteúdo do modelo multidimensional, com a opinião dos especialistas, efetuou-se a sua aplicação aos idosos em quatro consultas de enfermagem para cada um. Durante as consultas estabeleceram-se os diagnósticos, mensuraram-se os resultados e implementaram-se as intervenções de enfermagem, conforme o modelo e a avaliação clínica. Os especialistas validaram informações da anamnese e exame físico referentes às características definidoras, fatores relacionados e de risco dos dois diagnósticos e às dimensões fisiológica, psicológica e social, conforme propõe o MMES. A validação também confirmou que dos 13 diferentes resultados de enfermagem validados, 10 foram comuns em ambos os diagnósticos. Os resultados validados para os dois diagnósticos avaliaram Equilíbrio (0202), Cognição (0900), Estado nutricional (1004), Autocontrole da doença crônica (3102), Conhecimento: controle da dor (1843), Participação em programa de exercício físico (1633), Conhecimento: controle da doença crônica (1847), Conhecimento: prevenção de quedas (1828), Conhecimento: controle do peso (1841) e Estado de conforto (2008). Apenas dois dos 13 resultados foram validados para o diagnóstico SIF, sendo eles: Nível de fadiga (0007) e Autocuidado: atividades da vida diária (0300), e um resultado, Conhecimento: medicamento (1808), foi validado apenas para o diagnóstico RSIF. As intervenções de enfermagem da NIC, validadas para os dois diagnósticos de enfermagem, foram praticamente iguais. Das oito diferentes intervenções validadas apenas a Assistência ao Autocuidado (1800) foi validada exclusivamente para o diagnóstico SIF e as outras sete foram validadas para os dois diagnósticos. As intervenções destacam a importância da Promoção do exercício (0200), Aconselhamento nutricional (5246), Controle de medicamentos (2380), Estimulação cognitiva (4720), Melhora na socialização (5100), Prevenção contra quedas (6490) e Ensino sobre o processo da doença (5602). A segunda etapa mostrou que dos 28 idosos a maioria era do sexo feminino (17 - 60,7%), com idade média de 65,6 ± 6,3 anos e, desses, 23 idosos foram diagnosticados com RSIF e cinco com SIF. Dos resultados de enfermagem utilizados para avaliar idosos com RSIF e SIF percebeu-se melhora significativa na média dos escores dos seus indicadores: Participação em programa de exercício físico; Autocontrole da doença crônica; 7 Conhecimento: controle da doença crônica; Conhecimento: controle do peso; Conhecimento: prevenção de quedas e Estado de conforto. Os resultados Estado nutricional e Conhecimento: controle da dor tiveram melhora significativa nos escores dos indicadores somente para idosos com RSIF, assim como a avaliação do Autocuidado: atividades da vida diária para idosos com SIF. As intervenções que apresentaram efetividade estatisticamente significativa na utilização de suas atividades em idosos, com ambos os diagnósticos, foram: Ensino: processo da doença e Promoção do exercício, enquanto a intervenção Prevenção contra quedas foi encontrada somente em idosos com RSIF. Conclui-se que as sete intervenções de enfermagem validadas pelos especialistas foram implementadas aos idosos com diagnóstico de enfermagem RSIF e foram consideradas efetivas, tendo como base a avaliação de nove resultados que apontaram melhora significativa na comparação entre as médias da primeira e quarta consultas. Dentre as oito intervenções de enfermagem implementadas aos idosos com diagnóstico de enfermagem SIF, sete foram consideradas efetivas, tendo como base a avaliação de 11 resultados que apontaram melhora significativa na comparação entre as médias da primeira e quarta consultas. Dessa forma, conclui-se ainda, que o modelo multidimensional de cuidado ao idoso associado aos SLP contribui para a prática assistencial do enfermeiro na consulta de enfermagem, com vistas ao envelhecimento bem sucedido. Dentre as importantes implicações e contribuições dos resultados desta pesquisa está a possibilidade de apoiar a ligação entre resultados e intervenções validados com os diagnósticos de enfermagem RSIF e SIF, facilitando a avaliação de enfermagem e os cuidados de enfermagem aos idosos na prática clínica. Além disso, recomenda-se a construção de definições operacionais para os indicadores dos resultados de enfermagem. Uma limitação do estudo foi o fato de realizarmos a pesquisa com especialistas do mesmo país.<br>Comprehensive care for the elderly can be guaranteed through the use of the Nursing Process (PE), together with a theoretical framework such as the Multidimensional Model of Successful Aging (MMSA), which has a proposal for the evaluation of the elderly. There is, however, a gap to its use, since there are no studies that prove its effectiveness in the clinical practice of Nursing associated with the application of discipline classification systems such as NANDA-I, NIC and NOC. The objective of this study is to build an elderly care multidimensional model associated with the standardized NANDA-I, NIC and NOC Nursing language systems, applicable to the nursing consultation. The study was conducted in two different methodological steps. The first comprised a content validation study while the second a results research, which included a quasi-experimental study. The samples consisted of 15 specialists in Gerontology Nursing and 28 elderly people in a first consultation in the City of the Elderly, place of study, with age equal to or greater than 60 years, of both sexes, who presented the diagnosis of Nursing Risk of Syndrome of the Elderly (RSIF) or Fragile Elderly Syndrome (SIF), from May to October 2017. After the validation of the multidimensional model content, with the opinion of the specialists, it was applied to the elderly in four every elderly person. During the consultations the diagnoses were established, the results were measured and the Nursing interventions were implemented, according to the multidimensional model and the clinical evaluation. The specialists validated information about the anamnesis and the physical examination referring to the defining characteristics, related and risk factors of the two diagnoses and the physiological, psychological and social dimensions, as proposed by the MMSA. Validation also confirmed that of the 13 different validated Nursing outcomes, 10 were common in both diagnoses. The results validated for the two diagnoses evaluated: Equilibrium (0202), Cognition (0900), Nutritional status (1004), Self-control of chronic disease (3102), Knowledge: pain control (1843), Knowledge: control of chronic disease (1847), Knowledge: prevention of falls (1828), Knowledge: weight control (1841) and Comfort state (2008). Only two of the 13 results were validated for SIF diagnosis, being: Fatigue level (0007) and Self-care: activities of daily living (0300), and a result, Knowledge: medicine (1808), was validated only for the diagnosis RSIF. The Nursing interventions of the NIC, validated for the two Nursing diagnoses, were practically the same. Of the eight different validated interventions, only Self-care Assistance (1800) was validated exclusively for SIF diagnosis and the other seven were validated for both diagnoses. The interventions emphasize the importance of Promoting Exercise (0200), Nutrition Counseling (5246), Medication Control (2380), Cognitive Stimulation (4720), Improving Socialization (5100), Fall Prevention (6490) and Teaching the Process of the disease (5602). The second stage showed that of the 28 elderly, the majority were female (17-60.7%), with a mean age of 65.6 ± 6.3 years, and of these, 23 elderly were diagnosed with RSIF and five with SIF. Nursing results used to evaluate the elderly with RSIF and SIF showed a significant improvement in the mean of the scores of their indicators: Knowledge: control of chronic disease; Self-control of chronic disease; Knowledge: prevention of falls; Weight control; State of comfort and Participation in physical exercise program. The results Knowledge: pain control and nutritional status had significant improvement in the scores of indicators only for the elderly with RSIF, as well as the self-care evaluation: daily life activities for elderly with 9 SIF. The interventions that presented a statistically significant reduction in the use of their activities in the elderly, with both diagnoses, were Teaching: disease process and Exercise promotion, while the intervention Prevention of falls was found only in the elderly with RSIF. It is concluded that the seven nursing interventions validated by the specialists were implemented to the elderly with a diagnosis of RSIF Nursing and were considered effective, based on the evaluation of nine results that indicated a significant improvement in the comparison between the means of the first and fourth visits. Among the eight Nursing interventions implemented to the elderly with SIF Nursing diagnosis, seven were considered effective, based on the evaluation of 11 results that indicated a significant improvement in the comparison between the means of the first and fourth visits. Thus, it can be concluded that the multidimensional model of elderly care associated with standardized Nursing language systems contributes to the nurses practice in the nursing consultation, with a view to successful aging. Among the important implications and contributions of the results of this research is the possibility of supporting the link between results and validated interventions with the RSIF and SIF, facilitating nursing assessment and nursing care for the elderly in clinical practice. In addition, it is recommended to construct operational definitions for indicators of nursing outcomes. One limitation of the study was the fact that we conducted the research with specialists from the same country.
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Munro, Fiona E. "The role of NK1 and NK2 neurokinin receptors in the acute and sustained nociceptive activation of dorsal horn neurons." Thesis, University of Edinburgh, 1997. http://hdl.handle.net/1842/29900.
Full textAbstract:
The tachykinins substance P (SP) and neurokinin A (NKA) can be released from fine somatosensory afferents into the spinal cord by noxious cutaneous stimuli. This study assessed the role of their respective NK<SUB>1 </SUB>and NK<SUB>2</SUB> receptors and some putative intracellular mediators in both acute and sustained nociceptive inputs to dorsal horn neurons: (a) In anaesthetised rats, extracellular recordings were made from laminae III-V multireceptive neurons. The ionophoretic administration of NK<SUB>1</SUB> antagonists L-668,169, GR 82334 and [D-Pro<SUP>4</SUP>,D-Trp<SUP>7,9,10</SUP>Phe<SUP>11</SUP>]substance P-(4-11) failed to influence neuronal responses to noxious pinch or heat, but often enhanced responses to innocuous brush, whilst the NK<SUB>2</SUB> antagonist L-659,874 inhibited responses to noxious heat, but not pinch or brush. Selective NK<SUB>1</SUB> and NK<SUB>2</SUB> receptor agonists, [N-acetyl-Arg<SUP>6</SUP>,Sar<SUP>9</SUP>,Met(O<SUB>2</SUB>)<SUP>11</SUP>]SP<SUB>6-11</SUB> and GR 64349 respectively, both excited dorsal horn neurons. The contribution of NK<SUB>1</SUB> and NK<SUB>2</SUB> receptors to sustained neuronal activity induced by peripheral application of the C-fibre selective algogen mustard oil was then investigated. (b) Evidence for a role of protein kinase C (PKC) in mediating sustained nociceptive responses of rat horn neurons was provided by the blockade of mustard oil-, but not brush-evoked neuronal activation by the PKC inhibitors GF 109203X and chelerythrine and by SR 48968-sensitive subcellular translocation of [<SUP>3</SUP>H]phorbol 12,13-dibutyrate binding sites ipsilateral to mustard oil stimulation. (c) <I>In situ</I> hybridisation histochemistry (ISSH) demonstrated that expression of c-fos mRNA, induced in the superficial dorsal horn by peripheral application of mustard oil was inhibited by systemic administration of both RP 67580 and SR 48968. (d) The effects of intrathecally-applied NK<SUB>1</SUB> and NK<SUB>2</SUB> antagonists were assessed on thermally-evoked tail-flick and paw-flick behavioural responses. GR 82334 and L-659,874 had no effect alone, but in combination inhibited paw-flick. After inflammation induced by intraplantar injection of carrageenan, each was effective individually. These results provide evidence that spinal NK<SUB>2</SUB> receptors are involved in mediating both acute and sustained nociceptive transmission, probably acting through phosphoinositide hydrolysis and stimulation of protein kinase C(PKC). However, evidence for NK<SUB>1</SUB> receptor involvement was only obtained in sustained or inflammatory models of nociceptive transmission in the spinal dorsal horn.
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Balaguer, Núñez María Dolores. "Astrophysical studies on open clusters: NGC 1807, NGC 1817, NGC 2548 and NGC 2682." Doctoral thesis, Universitat de Barcelona, 2006. http://hdl.handle.net/10803/747.
Full textAbstract:
The aim of this thesis, devised as a collaboration between Spain and China, is the characterization of the open clusters NGC 1807, NGC 1817, NGC 2548 and NGC 2682, as well as the analysis of the results in the general framework of the Galactic clusters system. We have obtained astrometric catalogues from photographic plates (Shanghai Astronomical Observatory) and photometric catalogues from CCD <I>uvbyH-beta</i> photometry (Calar Alto and Roque de los Muchachos Observatories), and given membership lists for each cluster. Membership segregation recurs to the combination of parametric and nonparametric statistical methods, in a systematic approach. Moreover, we have determined the physical parameters of the clusters.<br/><br/>NGC1817, in Taurus, is a rich and old open cluster but very poorly studied. We have obtained photometry of a total of 7842 stars in an area of 65'x40' with a limiting magnitude of Combining astrometric and photometric criteria we have selected 1592 members. From this selection we found E(<i>b-y</i>) =0.19±0.05 (E(<i>B-V</i>) = 0.27), V0-MV = 10.9±0.6 and [Fe/H] = 0.34 ±0.26. From isochrone fitting we get an age of log <i>t</i> = 9.05±0.05 (1.1 Gyr). The study of the size of the cluster gives us a half-sample radius of rh =11.75' (6 pc). NGC1807 is a bright group of stars close to NGC1817. We have not found any support for considering NGC1807 a real physical cluster. NGC1817 is a very extended cluster, with member stars covering the area of NGC1807.<br/><br/>We have obtained photometry of NGC2548 (M48), in Hydra, for a total of 4806 stars in an area of 34'x34' with a limiting magnitude of V aprox. equals to 22. From the selection of 331 members we find E(<i>b-y</i>) = 0.06±0.03 (E(<i>B-V</i>) = 0.08), V0-MV =9.3±0.5 (725pc, that is around 200pc above the Galactic plane) and [Fe/H]= 0.24±0.27. Best isochrone fitting is for models with overshooting and an age of 400±100 Myr (log <i>t</i> =8.6). The size of the cluster gives us a half-sample radius of rh =14.38' (3.0pc).<br/><br/>NGC2682 (M67), in Cancer, is probably the best studied cluster of the Galaxy. We have used it as standard for the photometric transformations and thus, obtained accurate photometry of 1843 stars in an area of 50'x50' and with limiting magnitude <i>V</i> aprox. equals to 19. From the 776 members we get E(<i>b-y</i>) =0.03±0.03 (E(<i>B-V</i>) =0.04), V0-MV =9.7±0.2 and [Fe/H] =0.01±0.14. Comparing models with and without overshooting we adopt an age of 4.2±0.4 Gyr, coherent with previous studies. From the astrometric selection we get a half-sample radius of rh=9.84' (2.6pc).<br/><br/>All methods used, from the selection of a plate model for proper motions calculation, to the application of methods to the cluster/field segregation, have been rigorously evaluated. Besides the calculation of space velocities and Galactic orbits, we have studied mass functions, analysed mass segregation from luminosity functions, surface brightness profiles of the different stellar populations and relaxation times of the clusters. We have studied the existence of gaps in the main sequence and found a total of four gaps, one being a new detection.<br/><br/>RESUM: <br/><br/>"Estudis astrofísics de cúmuls oberts: NGC1807, NGC1817, NGC2548 i NGC2682"<br/><br/>L'objectiu d'aquesta tesi, producte d'una col·laboració entre Espanya i la Xina, és la caracterització dels cúmuls oberts NGC1807, NGC1817, NGC2548 i NGC2682, així com l'anàlisi dels resultats en el context del sistema de cúmuls oberts de la Galàxia. Hem obtingut catàlegs astromètrics a partir de plaques fotogràfiques (Observatori Astronòmic de Shanghai) i fotomètriques, a partir de fotometria CCD <I> uvbyH-beta </I>(Observatoris de Calar Alto i Roque de los Muchachos), i generat llistes de membres per a cada cúmul. La segregació de membres fa servir de manera sistemàtica la combinació de mètodes paramètrics i no paramètrics. Tanmateix, hem determinat els paràmetres físics dels cúmuls. <br/><br/>NGC1817, en Taure, és un cúmul vell i ric però molt poc estudiat. Van obtenir fotometria d'un total de 7842 estels en un àrea de 65'x40' fins a una magnitud V aprox. igual a 22. Combinant criteris astromètrics i fotomètrics, hem seleccionat 1592 estels membres. A partir d'aquesta selecció es van encontrar valors de E(<i>b-y</i>) =0.19±0.05 (E(<i>B-V</i>)= 0.27), V0-MV = 10.9±0.6 i [Fe/H] = 0.34±0.26. Dels ajustos d'isòcrones podem deduir una edat de log <i>t</i> = 9.05±0.05 (1.1 Ga). La determinació de la grandària del cúmul ens dóna un radi de semi mostra de rh =11.75' (6.0 pc). NGC1807 és un grup de estels molt brillants a prop de NGC1817. Després de l'estudi fotomètric i astromètric podem concloure que no s'ha trobat cap evidència a favor de l'existència de NGC1807 com cúmul físic real. Per contra, part dels seus estels pertanyen a NGC1817, que és un cúmul molt extens.<br/><br/>De NGC2548 (M48), en Hidra, hem obtingut fotometria per a un total de 4806 estels en un àrea de 34'x34' fins a una magnitud límit de V 22. De la selecció final de 331 estels membres podem trobar E(<i>b-y</i>)= 0.06±0.03 (E(<i>B-V</i>)= 0.08), V0-MV =9.3±0.5 (725pc, és a dir, al voltant d'uns 200pc per sobre del pla galàctic) i [Fe/H]= 0.24 ±0.27. El millor ajust d'isòcrones resulta per a models amb convecció penetrant d'una edad de 400±100Ma (log t =8.6). El radi de semi mostra calculat a partir de la segregació astromètrica es rh =14.38' (3.0pc). NGC2682 (M67), en Càncer, és probablement el cúmul obert vell més estudiat de la Galàxia. En utilitzar-lo com a estàndard a la transformació de la fotometria, hem obtingut uns resultats de gran qualitat i extensió amb un total de 1843 estels en un àrea de 50'x50' i una magnitud límit <i>V</i> aprox. igual a 19. D'un total de 776 estels membres, hem trobat E(<i>b-y</i>) =0.03±0.03 (E(<i>B-V</i>)=0.04), V0-MV =9.7±0.2 i [Fe/H] =0.01±0.14. De la comparació entre models de convecció penetrant i models canònics, hem adoptat una edat de 4.2±0.4Ga, en coincidència amb estudis anteriors. El radi de semi mostra de laselecció astromètrica es rh=9.84' (2.6pc).<br/><br/>Tots els mètodes utilitzats, des de l'elecció del model de placa per al càlcul de moviments propis fins l'aplicació de mètodes per a la segregació de cúmul i camp, han estat avaluats de manera rigorosa i crítica, adoptant-los a cada cas particular. A més del càlcul de les velocitats espacials i òrbites galàctiques, s'han estudiat les funcions de massa, analitzant la segregació de masses a partir de funcions de lluminositat, perfils de brillantor superficial de les distintes poblacions d'estels i els temps de relaxació dels cúmuls. Hem estudiat l'existència de buits a la seqüència principal i n'hem trobat un total de quatre, un dels quals representa una nova detecció.<br>"Estudios astrofísicos de cúmulos abiertos: NGC 1807, NGC 1817, NGC 2548 y NGC 2682ç"<br/><br/>El objetivo de esta tesis, producto de la colaboración entre España y China, es la caracterización de los cúmulos abiertos NGC 1807, NGC 1817, NGC 2548 y NGC 2682, así como el análisis de los resultados en el contexto del sistema de cúmulos de la Galaxia. Se han obtenido catálogos astrométricos a partir de placas fotográficas (Observatorio Astronómico de Shanghai) y fotométricos a partir de fotometría CCD <i>uvbyH-beta</i> (Observatorios de Calar Alto y Roque de los Muchachos), y generado listas de miembros para cada cúmulo. La segregación de miembros recurre de manera sistemática a la combinación de métodos estadísticos paramétricos y no-paramétricos. Asimismo, se han determinado los parámetros físicos de los cúmulos.<br/><br/>NGC1817, en Tauro, es un cúmulo viejo y rico pero poco estudiado. Se ha obtenido fotometría de un total de 7842 estrellas en un área de 65'x40' con magnitud límite V aprox. igual a 22. Combinando criterios astrométricos y fotométricos, se han seleccionado 1592 estrellas miembro. A partir de esta selección se encontraron los valores de E (<i>b-y</i>) =0.19±0.05 (E(<i>B-V</i>)= 0.27), V0-MV= 10.9±0.6 i [Fe/H] = 0.34±0.26. Del ajuste de isocronas se obtiene una edad delog <i>t</i> = 9.05±0.05 (1.1 Ga). La determinación del tamaño del cúmulo da un radio de semimuestra de rh =11.75' (6.0 pc). NGC1807 es un grupo de estrellas brillantes cercano a NGC1817. Tras el estudio fotométrico y astrométrico podemos concluir que no hay ninguna evidencia a favor de la existencia de NGC1807 como un cúmulo físico real. Al contrario, parte de sus estrellas forman parte de NGC1817 que es un cúmulo muy extenso.<br/><br/>De NGC2548 (M48), en Hidra, hemos obtenido fotometría de un total de 4806 estrellas en un area de 34'x34' con una magnitud límite de V aprox. igual a 22 . De la selección final de 331 estrellas miembro encontramos E(<i>b-y</i>)= 0.06±0.03 (E(<i>B-V</i>) = 0.08), V0-MV =9.3±0.5 (725pc,es decir, alrededor de 200pc sobre el plano galáctico) y [Fe/H]= 0.24±0.27. El mejor ajuste de isocronas es para modelos con convección penetrante con una edad de 400±100Ma (log <i>t</i> =8.6). El radio de semimuestra calculado a partir de la segregación astrométrica es rh =14.38' (3.0pc).<br/><br/>De NGC2682 (M67), en Cáncer, es probablemente el cúmulo abierto viejo más estudiado de la Galaxia. Al utilizarlo como estándar en la transformación de la fotometría, hemos obtenido unos resultados de gran calidad y extensión con un total de 1843 estrellas en un área de 50'x50' y una magnitud límite <i>V</i> aprox. igual a 19. Del total de 776 miembros, encontramos E(<i>b-y</i>) =0.03±0.03 (E(<i>B-V</i>) =0.04), V0-MV =9.7±0.2 y [Fe/H] =0.01±0.14. De la comparación entre modelos de convección penetrante y modelos canónicos, adoptamos una edad de 4.2±0.4Ga, en coincidencia con estudios anteriores. El radio de semimuestra de la selección astrométrica es rh=9.84' (2.6pc).<br/><br/>Todos los métodos utilizados, desde la elección del modelo de placa para el cálculo de los movimientos propios, hasta la aplicación de métodos a la segregación de cúmulo y campo, han sido evaluados de manera rigurosa. Además del cálculo de las velocidades espaciales y órbitas galácticas, se han estudiado las funciones de masa, analizado la segregación de masas a partir de funciones de luminosidad, perfiles de brillo superficial de las distintas poblaciones estelares y los tiempos de relajación de los cúmulos. Hemos estudiado la existencia de huecos en la secuencia principal y encontrado un total de cuatro huecos, uno de los cuales es una nueva detección.
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Tseng, Hui-Chen. "Use of standardized nursing terminologies in electronic health records for oncology care: the impact of NANDA-I, NOC, and NIC." Diss., University of Iowa, 2012. https://ir.uiowa.edu/etd/1409.
Full textAbstract:
The purpose of this study was to identify the characteristics of cancer patients and the most frequently chosen nursing diagnoses, outcomes and interventions chosen for care plans from a large Midwestern acute care hospital. In addition the patients' outcome change scores and length of stay from the four oncology specialty units are investigated. Donabedian's structure-process-outcome model is the framework for this study. This is a descriptive retrospective study. The sample included a total of 2,237 patients admitted on four oncology units from June 1 to December 31, 2010. Data were retrieved from medical records, the nursing documentation system, and the tumor registry center. Demographics showed that 63% of the inpatients were female, 89% were white, 53 % were married and 26% were retired. Most patients returned home (82%); and 2% died in the hospital. Descriptive analysis identified that the most common nursing diagnoses for oncology inpatients were Acute Pain (78%), Risk for Infection (31%), and Nausea (26%). Each cancer patient had approximately 3.1 nursing diagnoses (SD=2.5), 6.3 nursing interventions (SD=5.1), and 3.7 nursing outcomes (SD=2.9). Characteristics of the patients were not found to be related to LOS (M=3.7) or outcome change scores for Pain Level among the patients with Acute Pain. Specifically, 88% of patients retained or improved outcome change scores.
The most common linkage of NANDA-I, NOC, and NIC (NNN), a set of standardized nursing terminologies used in the study that represents nursing diagnoses, nursing-sensitive patient outcomes and nursing interventions, prospectively, was Acute Pain--Pain Level--Pain Management. Pain was the dominant concept in the nursing care provided to oncology patients. Risk for Infection was the most frequent nursing diagnosis in the Adult Leukemia and Bone Transplant Unit. Patients with both Acute Pain and Risk for Infection may differ among units; while the traditional study strategies rarely demonstrate this finding. Identifying the pattern of core diagnoses, interventions, and outcomes for oncology nurses can direct nursing care in clinical practice and provide direction for future research tot targets areas of high impact and guide education and evaluation of nurse competencies.
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Lemos, Dayanna Machado Pires. "Implementação das taxonomias NANDA-I, NOC e NIC no planejamento da alta hospitalar para pacientes com insuficiência cardiaca e diabetes mellitus." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2016. http://hdl.handle.net/10183/183914.
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O planejamento de alta é uma etapa importante do preparo do paciente para os cuidados em domicílio. O enfermeiro tem papel fundamental neste processo, atuando na identificação dos problemas de saúde e na educação de pacientes e familiares. As orientações para alta fazem parte do Processo de Enfermagem, embora não sejam priorizadas dentre as atividades de responsabilidade do enfermeiro. A falta de um planejamento efetivo de alta hospitalar pode ser um dos fatores que contribui para elevar as taxas de reinternações hospitalares em indivíduos com Insuficiência cardíaca (IC) ou Diabetes mellitus (DM). Assim, este estudo teve como objetivo avaliar o efeito da implementação de um planejamento de alta hospitalar estruturado nas taxonomias da NANDA-International, Nursing Interventions Classification (NIC) e Nursing Outcomes Classification (NOC) para pacientes com IC e DM. Estudo quantitativo quasi-experimental realizado em unidades de internação clínica e emergência do Hospital de Clínicas de Porto Alegre (aprovação nº 13-0194). A amostra foi composta por pacientes que reinternaram de janeiro de 2014 a setembro de 2015 por descompensação de IC ou DM e apresentaram o diagnóstico de enfermagem Autocontrole ineficaz da saúde (AIS) (00078). Durante a internação foram implementadas as intervenções NIC: Ensino: processo de doença (5602), Ensino: medicamentos prescritos (5616) e Ensino: dieta prescrita (5614) em três momentos. Antes e após as intervenções foram avaliados os resultados NOC Conhecimento: controle do diabetes (1820) e Conhecimento: controle da insuficiência cardíaca congestiva (1835), com 32 e 37 indicadores respectivamente. Cada resultado teve seus indicadores definidos operacionalmente e avaliados em Escala de Likert de 5 pontos, sendo 1 o pior resultado e 5 o melhor. Foram incluídos 28 pacientes, sendo 14 com DM e 14 com IC, a maioria do sexo masculino com média de idade 63,1±10,6 anos. Houve aumento significativo das médias dos resultados NOC após a implementação das intervenções NIC. O resultado NOC Conhecimento: controle da insuficiência cardíaca congestiva passou de 2,05±0,28 para 2,54±0,30 (P = 0,002) e o resultado NOC Conhecimento: controle do diabetes passou de 2,61±0,55 para 3,21±0,57 (P=0,000). Entre os indicadores com aumento da média em um ponto ou mais destacam-se em IC Estratégias para equilibrar atividade e repouso, Estratégias de controle de edema dependente e Ações básicas do coração. Os pacientes com DM obtiveram maior aumento na pontuação: Impacto de doença grave no nível da glicose do sangue, Descarte correto de seringas e agulhas e Práticas de cuidados preventivos dos pés. Estes achados sugerem que o planejamento de alta realizado durante a internação hospitalar para pacientes com IC e DM descompensadas e com o DE AIS utilizando intervenções de ensino NIC melhoram a pontuação dos resultados de enfermagem NOC, podendo interferir nos desfechos de saúde desta população.<br>The discharge planning consists on an important stage for patient preparation on domestic care. Nurses’ role is very important in this process, since he/she acts identifying the problems in health and in the education of patients and families. The guidance for discharge is a part of the nursing process, although it is not prioritized among the nurses’ responsibility activities. The lack of an effective discharge planning does not develop an autonomy of self- care, which can elevate the rates of rehospitalization for heart failure and diabetes mellitus. For this reason, this study aimed to evaluate the effect of implementing a hospital discharge planning based on the taxonomies of NANDA-I, Nursing Intervention Classification (NIC) and Nursing Outcomes Classification (NOC), for patients with heart failure and diabetes mellitus. This is a quasi-experimental quantitative study, which was carried out at clinical and hospital emergency units at the Hospital de Clínicas de Porto Alegre (approval nº 13- 0194). The sample was composed by patients that rehospitalized from January 2014 to September 2015 for heart failure decompensation or DM and presented the nursing diagnosis (ND) Ineffective self-health management (ISM) (00078). During hospitalization, the interventions NIC Teaching: disease process (5602), Teaching: prescribed medication (5616) and Teaching: prescribed diet (5614) were implemented in three moments. Before and after the three given guidance, the results from NOC Knowledge: control of diabetes (1820) and Knowledge: control of congestive heart failure (1835) were evaluated, with 32 and 37 indicators, respectively. Each result had its own operationally defined indicators and evaluated on a Likert Scale level of 5 points, being 1 the worst and 5 the best result. Twenty- eight patients were included, having 14 DM and 14 HF, the most part of them was male and were 63,1±10,6 years old. There was a significant increasing on the averages of results NOC after the implementation of NIC interventions. The result NOC Knowledge: control of congestive heart failure went from 2,05±0,28 to 2,54±0,30 (P = 0,002) and the result NOC Knowledge: control of diabetes went from 2,61±0,55 to 3,21±0,57 (P=0,000). Among the indicators with increased average at point or more, Strategies to balance activity and rest, Strategies to control dependent edema and Heart basic actions were highlighted. The patients with DM obtained increased scores at Impact of serious disease at blood glucose levels, Correct disposal of syringes and needles and Practice for preventive foot care. These findings suggest that the discharge planning, elaborated during hospitalization, for patients with HF and ND ISM using interventions NIC, improve the scores of results on nursing NOC, which might interfere in the denouement of health of this population.<br>El planeamiento de descarga consiste en una importante etapa del preparo del paciente para los cuidados en casa. Los enfermeros tienen papel fundamental en este proceso, actuando en la identificación de las necesidades y en la educación de pacientes y familiares. Las orientaciones para descarga hacen parte del proceso de enfermería, aunque no sean priorizadas de entre las actividades de responsabilidad del enfermero. La falta de planeamiento efectivo de descarga del hospital no desenvuelve la autonomía para el autocuidado, pudendo elevar las tajas de reinternaciones en el hospital en individuos acometidos por insuficiencia cardiaca y diabetes mellitus. En función de esto, esto estudio tuve como objetivo evaluar la implementación de un planeamiento de descarga del hospital con ECNT, teniendo base en las taxonomías NANDA-I, Nursing Intervention Classification (NIC) y Nursing Outcomes Classifications (NOC), para pacientes con insuficiencia cardiaca y diabetes mellitus. Este es un estudio cuantitativo cuasi-experimental realizado en unidades de internación clínica y emergencia del Hospital de Clínicas de Porto Alegre (aprobación nº 13-0194). La amuestra fue constituida por pacientes que reinternaran de Enero 2014 hasta Septiembre 2015 por descompensación de Insuficiencia Cardiaca (IC) o Diabetes Mellitus (DM) y que presentaran el diagnostico de enfermería (DE) Autocontrol ineficaz de la salud (AIS) (00078). Durante la internación fueron implementadas las intervenciones NIC Enseñanza: proceso de enfermedad (5602), Enseñanza: medicamentos prescritos (5616) y Enseñanza: dieta prescrita (5614). Antes y después de las tres orientaciones, fueron evaluados los resultados NOC Conocimiento: control del diabetes (1820) y Conocimiento: control de insuficiencia cardiaca congestiva (1835), con 32 y 37 indicadores respectivamente. Cada resultado tuve sus indicadores definidos operacionalmente y evaluados en Escala Likert de 5 puntos, siendo 1 lo peor resultado y 5 lo mejor. Veinte-ocho pacientes fueron inclusos, siendo 14 DM y 14 insuficiencia cardíaca, la mayoría era hombres y tenían 63,1±10,6 años de edad. Hube un aumento significante de medias de resultados NOC después de la implementación de intervenciones NIC. El resultado NOC Conocimiento: control de insuficiencia cardiaca congestiva pasó de 2,05±0,28 para 2,54±0,30 (P = 0,002) y el resultado NOC Conocimiento: control del diabetes pasó de 2,61±0,55 para 3,21±0,57 (p=0,000). Entre los indicadores con aumento de la media en un punto o más se destacan en IC Estrategias para equilibrar actividad y resto, Estrategias de control de edema dependiente y Acciones básicas del corazón. Los pacientes con DM obtuvieran mayor aumento en la puntuación: Impacto de enfermedad grave en el nivel de glucosa de la sangre, Descarte correcto de seringas y agujas y Prácticas de cuidados preventivos de los pies. Estos resultados sugieren que el planeamiento de descarga hospitalaria realizado durante la internación hospitalaria para pacientes con ECNT y con DE AIS utilizando intervenciones de enseñanza NIC mejoran la puntuación de los resultados de enfermería NOC, pudendo interferir en los desenlaces de salud de esta población.
Books on the topic "NKC"
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Obichere, Chris Nduka. Nku Di Na Mba: Nke si n'aka. Alphabet Nigeria Publishers, 2000.
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Holmberg, Eduardo. Viaje maravilloso del señor Nic-Nac al planeta Marte. Colihue, 2006.
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McCloskey, Dochterman Joanne, Johnson Marion 1936-, and University of Iowa. Center for Nursing Classification., eds. NIC interventions & NOC outcomes linked to the OASIS information set. Center for Nursing Classification, 2000.
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1946-, Wilkinson Judith M., ed. Prentice Hall nursing diagnosis handbook with NIC interventions and NOC outcomes. 8th ed. Pearson/Prentice Hall, 2005.
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Wilkinson, Judith M. Prentice Hall nursing diagnosis handbook with NIC interventions and NOC outcomes. 9th ed. Pearson Prentice Hall, 2009.
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Wilkinson, Judith M. Prentice Hall nursing diagnosis handbook with NIC interventions and NOC outcomes. 8th ed. Pearson/Prentice Hall, 2005.
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Wilkinson, Judith M. Prentice Hall nursing diagnosis handbook with NIC interventions and NOC outcomes. 9th ed. Pearson Prentice Hall, 2009.
Find full textBook chapters on the topic "NKC"
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Brown, Michael G., Anthony A. Scalzo, and Wayne M. Yokoyama. "The NKC and regulation of natural killer cell-mediated immunity." In Major Histocompatibility Complex. Springer Japan, 2000. http://dx.doi.org/10.1007/978-4-431-65868-9_22.
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Rumsey, W. L., and J. K. Kerns. "Combined Tachykinin NK1, NK2, and NK3 Receptor Antagonists." In Handbook of Experimental Pharmacology. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-642-18891-6_9.
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van Haaren, Elly, Jennie Mast, Helen de Graaf-Waar, and Rens Martijn. "Nanda-I, NIC en NOC." In Klinisch redeneren en verpleegkundige classificaties. Bohn Stafleu van Loghum, 2017. http://dx.doi.org/10.1007/978-90-368-1708-0_5.
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Andrews, Anne M., Greg A. Gerhardt, Lynette C. Daws, et al. "NKA." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_4414.
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Andrews, Anne M., Greg A. Gerhardt, Lynette C. Daws, et al. "NK2." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_6034.
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Andrews, Anne M., Greg A. Gerhardt, Lynette C. Daws, et al. "NK3." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_6035.
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Andrews, Anne M., Greg A. Gerhardt, Lynette C. Daws, et al. "NKB." In Encyclopedia of Psychopharmacology. Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-68706-1_6036.
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Pannu, Neesh, Xiaoyan Wen, John A. Kellum, et al. "NAC." In Encyclopedia of Intensive Care Medicine. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-00418-6_1917.
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Vauclair, Marc. "NFC." In Encyclopedia of Cryptography and Security. Springer US, 2011. http://dx.doi.org/10.1007/978-1-4419-5906-5_295.
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Yuan, Zhijia. "NEC." In The Hybrid Factory in Europe. Palgrave Macmillan UK, 2004. http://dx.doi.org/10.1057/9780230523654_20.
Full textConference papers on the topic "NKC"
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Shanmuganathan, M., and C. Nalini. "Expression of Concern for: Face Detection based on Extraction by K-NNC and NMC Framework." In 2020 3rd International Conference on Intelligent Sustainable Systems (ICISS). IEEE, 2020. http://dx.doi.org/10.1109/iciss49785.2020.10702803.
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Tsugawa, Takuji. "Case Study of Impeller Profile Considering Additional Parameters." In ASME 2004 Heat Transfer/Fluids Engineering Summer Conference. ASMEDC, 2004. http://dx.doi.org/10.1115/ht-fed2004-56059.
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In the previous paper, the optimum meridian profile of impeller was obtained for various specific speed by means of five shape factors. In this paper, the optimum meridian profile of impeller is obtained by means of eight shape factors. The basic five shape factors are inlet relative flow angle β1, turning angle Δβ, axial velocity ratio kc = Cm2/Cm1 impeller diameter ratio kd = D1c/D2c and outlet hub-tip ratio ν2 (β1 and Δβ are in mid span stream surface). The additional three parameters are three stream lines solidity (tip solidity σt, mid span solidity σc, and hub solidity σh). The blade length of impeller meridian profile is able to obtain by additional three parameters. The method of optimization is the calculation of hydraulic efficiency and suction specific speed in all combinations of eight shape parameters. The number of five shape factors are expressed by Nβ1, NΔβ, Nkc, Nkd, Nν2. The number of calculations is expressed by Nβ1 × NΔβ × Nkc × Nkd × Nν2. For example, Nβ1 = NΔβ = Nkc = Nkd = Nν2 = 40, the number of calculations is about 100000000. The calculation time is about 2 hours. The best parameters are selected in 100000000 cases. In case of eight shape factors, the number of calculation is Nβ1 × NΔβ × Nkc × Nkd × Nν2 × Nσt × Nσc × Nσh. Nβ1 = NΔβ = Nkc = Nkd = Nν2 = Nσt = Nσc = Nσh = 10, the number of calculation is 100000000. In this case, the calculation time of eight shape factors is as same as that of five shape factors. By means of this method, the more detailed optimum mixed flow impeller meridian shape is obtained. In case study, the best 1000 optimum meridian profiles and the best design parameter are selected for few kinds of specific speed using eight dimensional optimum method. In the previous paper, the mixed flow angle on tip meridian stream line isn’t able to be decided by this optimization using diffusion factor. But, in this paper, the mixed flow angle is able to be decided by the number of blade and optimum solidity. As the best solidity of three stream lines is obtained, the axial coordinates of impeller inlet and outlet are obtained. The more detailed optimum mixed flow impeller meridian shape is drawn.
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Liao, Ying, and Jianzu Wu. "Strength of Ties, Firm Age and Innovation: An NKC-Model Simulation." In 2011 International Conference on Information Technology, Computer Engineering and Management Sciences (ICM). IEEE, 2011. http://dx.doi.org/10.1109/icm.2011.38.
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Wu, Wei-wei, Ye-xin Liu, Huan-di Zhang, and Dan-dan Jiang. "The relationship between technology management and technological capability based on NKC model." In 2014 International Conference on Management Science and Engineering (ICMSE). IEEE, 2014. http://dx.doi.org/10.1109/icmse.2014.6930426.
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Tsugawa, Takuji. "Case Study of Improved High Specific Speed Radial Impeller." In ASME/JSME 2003 4th Joint Fluids Summer Engineering Conference. ASMEDC, 2003. http://dx.doi.org/10.1115/fedsm2003-45112.
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It is usually thought that the axial impeller is used for high specific speed impeller and the radial impeller is used for low specific speed impeller. In the previous paper, the optimum meridian profile of axial impeller and radial impeller were obtained for various specific speed by means of the optimization of four shape factors using diffusion factor. The four shape factors were inlet relative flow angle β1, turning angle Δβ, axial velocity ratio (meridian velocity ratio) kc = Cm2/Cm1 and impeller diameter ratio kd = D1c/D2c in mid span stream surface. In case of axial impeller, the optimum meridian profiles agreed with meridian profiles of conventional impellers. To develop the radial high specific speed impeller, the optimum four shape factors of radial high specific speed impellers were calculated by diffusion factor. And the optimum meridian profiles of radial high specific speed impellers were proposed. In case of the radial impeller, the hub diameter is equal to the tip diameter in impeller outlet (the outlet hub-tip ratio is 1.0). And in axial impeller, the outlet blade height depends on the outlet hub-tip ratio. On the other hand, in mixed flow impeller, the outlet hub-tip ratio is various and the outlet blade height is independent of the outlet hub-tip ratio. To obtain the optimum meridian profile of mixed flow impeller, the hub-tip ratio of impeller outlet ν2 is adopted new additional independent shape factor for optimization in this paper. The mixed flow angle on tip meridian stream line (= 0 degree in axial impeller, = 90 degrees in radial impeller) isn’t able to be decided by this optimization using diffusion factor. But, the mixed flow angle will be decided by the number of blade and solidity. And, it will be decided by meridian velocity distribution from hub to tip for each specific speed of impeller. So, in this paper the five shape factors are used for optimization by diffusion factor. (β1, Δβ, kc, kd, ν2) The optimum meridian profiles of mixed flow impellers for various specific speed are obtained. The relative efficiency or the cavitation performance of mixed flow impeller is better than that of radial or axial impeller. In this optimum method, the relative efficiency and the cavitation performance are calculated for all specified combinations of five shape factors. The number of five shape factors are expressed by Nβ1, NΔβ, Nkc, Nkd and Nν2. The number of calculations is expressed by Nβ1 × NΔβ × Nkc × Nkd × Nν2. The calculation time of five shape factors method is Nν2 times the calculation time of four shape factors method. Then, the best 1000 combinations of five shape factors are plotted on β1 - Δβ, kc - kd and kd - ν2 plane. The aspect of the best 1000 optimum conditions are found by these three figures. In initial step of impeller design, the result of the efficiency and cavitation performance of impeller calculated in optimum principal design parameters is important. The principal design parameters are hub-tip ratio, inlet-outlet diameter ratio, axial velocity ratio, solidity, inlet flow angle, turning angle and blade number. The author proposed the optimum meridian profile design method by diffusion factor for various condition of design parameters. There is a good correlation between the optimum hub-tip ratio and the specific speed considering cavitation performance. The optimum solidity is obtained for the specific speed considering efficiency and cavitation performance. It was found that the optimum meridian profile of high specific speed impeller with appropriate efficiency and cavitation performance had large inclination on hub and tip stream lines. The calculated data base is five dimensional using five shape factors β1, Δβ, kc, kd and ν2. Using the five shape factors in case of the best efficiency, the optimum meridian profile of improved radial flow impeller is able to be calculated. At first step of the case study, the best 1000 optimum meridian profiles and the best design parameter are selected using five dimensional optimum method. Next, the blade section shape of impeller is decided by the blade or cascade design method. Using impeller flow analysis, the cavitation performance decided by 3% head reduction is calculated. Finally, the relations between the many type of meridian profile and its impeller performance by flow analysis are obtained. These relations are very useful for new type of high specific speed impeller design. Consequently, radial impellers and axial impellers are improved by the consideration of the additional shape factor, that is, outlet hub-tip ratio ν2. This calculation shows that the improved radial high specific speed impeller considering outlet hub-tip ratio is used for high suction specific speed and high efficiency.
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"PS-095 - EFECTOS A LARGO PLAZO DEL CONSUMO DE SUSTANCIAS DE ABUSO: CUIDADOS DE ENFERMERÍA EN EPISODIO PSICÓTICO." In 24 CONGRESO DE LA SOCIEDAD ESPAÑOLA DE PATOLOGÍA DUAL. SEPD, 2022. http://dx.doi.org/10.17579/abstractbooksepd2022.ps095.
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INTRODUCCIÓN El consumo de sustancias de abuso, y sobre todo a edades tempranas, genera efectos adversos y negativos sobre la salud mental a medio y largo plazo, más allá de los efectos derivados de la dependencia y abstinencia. MATERIAL Y MÉTODOS Varón de 22 que ingresa en la Unidad De Hospitalización Breve (UHB) tras episodio de agitación psicomotriz con ideación delirante de persecución y autorreferencial. Ansiedad y labilidad emocional. En este momento escaso insight y abandono total de la medicación. Resultado de sustancias de abuso en orina negativo, aunque el paciente reconoce consumos puntuales. Previamente, consta un ingreso en la UHB por psicosis secundaria a consumo de sustancias de abuso (cocaína y cannabis). NANDA (000276) Autogestión ineficaz de la salud. NOC (1608) Control de síntomas. NIC (5602) Enseñanza: proceso de enfermedad. NIC (5616) Enseñanza: medicación prescrita. NANDA (00199) Planificación ineficaz de las actividades. NOC (1614) Autonomía personal NIC (4410) Establecimiento de objetivos comunes. NIC (1805) Ayuda con el autocuidado. NANDA (00146) Ansiedad. NOC (1402) Control de la ansiedad. NOC (1403) Autocontrol del pensamiento distorsionado. NIC (5230) Mejorar el afrontamiento RESULTADOS Y CONCLUSIONES El patrón de consumo previo unido a sus antecedentes personales (Trastorno psicóticos por consumo de sustancias de abuso) posiblemente haya sido determinante para este nuevo episodio de agitación psicomotriz. El abordaje terapéutico requiere la coordinación del equipo multidisciplinar. El plan de cuidados y las intervenciones llevadas a cabo por las enfermeras desempeñan un papel fundamental. Al alta, el paciente consiguió la adquisición de un adecuado insight, mostrando conciencia de enfermedad y aceptable juicio de realidad.
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Ferlisi, Mark J., Raymond A. West, and David R. Lewis. "The Rulemaking Process and Its Effect on the Use of ASME Nuclear Codes and Standards in the USA." In 16th International Conference on Nuclear Engineering. ASMEDC, 2008. http://dx.doi.org/10.1115/icone16-48721.
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The ASME Board on Nuclear Codes & Standards (BNCS) has a standing Task Group on Regulatory Endorsement (TG-RE) that is actively involved with obtaining endorsement of ASME Nuclear Codes and Standards (NC&S) used in the USA. However, all ASME NC&S that are required to be met by law in the USA must first be endorsed in the Code of Federal Regulations (CFR), specifically in Title 10, Section 50.55a, “Codes and standards.” Similarly, all Code Cases permitted by law to be used, as alternatives, must be approved for use in other United States Nuclear Regulatory Commission (NRC) documents such as NRC Regulatory Guides endorsed in the NRC rules. The NRC uses a rulemaking process to amend Section 50.55a to endorse and approve new or updated NC&S, and thus controls and mandates the use of ASME NC&S in the USA. The rulemaking process is very structured and is not very flexible. This paper describes how the TG-RE is working to improve and expedite the process by which the NRC endorses our ASME NC&S. Because the NRC influences international regulatory action, this paper is written to inform the international nuclear engineering community about the process by which endorsement of NC&S occurs in the USA and what actions are being taken to improve that process.
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Araya Chavarría, Kenly, Ruth Rojas Villegas, Marianelly Esquivel Alfaro, et al. "Aprovechamiento de los residuos de piña para la producción de celulosa nanofibrilar (NFC) y nanocelulosa cristalina (NCC)." In I Congreso Internacional de Ciencias Exactas y Naturales. Universidad Nacional, 2019. http://dx.doi.org/10.15359/cicen.1.62.
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Los residuos generados a partir de la siembra de piña en Costa Rica, se consideran un problema, debido a su lenta degradación y la utilización de agroquímicos para desecarla en campo. A partir de esta biomasa fue posible extraer tanto nanofibras de celulosa (NFC) como nanocristales (NCC). La NFC se obtuvo por medio de una oxidación mediada por TEMPO y posterior homogeneización mecánica, mientras que los NCC se obtuvieron aplicando una hidrolisis ácida con H2SO4. Se lograron evaluar las propiedades térmicas y morfológicas de ambas nanoestructuras, con el fin de proponer ideas para futuras aplicaciones y de esta forma dar un valor agregado a esta biomasa, que se considera un residuo.
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Shanmuganathan, M., and C. Nalini. "Face Detection based on Extraction by K-NNC and NMC Framework." In 2020 3rd International Conference on Intelligent Sustainable Systems (ICISS). IEEE, 2020. http://dx.doi.org/10.1109/iciss49785.2020.9315955.
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Flores Vivian, Ismael, Joshua Hoheneder, Lourdes Vergara Alvarez, and Konstantin Sobolev. "Desempeño de compuestos con fibras de alcohol polivinílico y nano-fibras/tubos de carbono." In HAC2018 - V Congreso Iberoamericano de Hormigón Autocompactable y Hormigones Especiales. Universitat Politècnica València, 2018. http://dx.doi.org/10.4995/hac2018.2018.6473.
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La adición de fibras en compuestos a base de cemento portland es una práctica común para la prevención de la formación de grietas y para incrementan la resistencia a la flexión. En esta investigación, se estudiaran los compuestos fibro-reforzados (CFR) con fibras de polivinilo alcohol (PVA), reforzadas con nanofibras de carbono (NFC) o nanotubos de carbono (NTC). Los especímenes fabricados fueron ensayados a la resistencia a la flexión y a la conductividad eléctrica en agua o en solución con NaCl. Los resultados demostraron una dependencia de los especímenes al tipo de solución a la cual fueron expuestos. Se demostró que la sensitivdad a la deformación y a la solución de NaCl puede ser incrementada por la adición de los NTC. Los resultados en el incremento de la conductividad con los compuestos de NTC pueden ser escalables para las aplicaciones de monitoreo no-destructivo en estructuras de concreto que requieran una mejora integral bajo las cargas aplicadas y estabilidad en ambientes deletéreos.DOI: http://dx.doi.org/10.4995/HAC2018.2018.6473
Reports on the topic "NKC"
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Lussier, James W., Rex Michael, and Adela Frame. NTC-CD System: Recreating the NTC Experience. Defense Technical Information Center, 1997. http://dx.doi.org/10.21236/ada328363.
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Morrison, Robert W. NBC Filter Performance. Defense Technical Information Center, 2001. http://dx.doi.org/10.21236/ada397007.
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Belcher, Steven W., David L. Reese, and Kletus S. Lawler. Improving NEC Fit. Defense Technical Information Center, 2015. http://dx.doi.org/10.21236/ada622330.
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Evans, Donald L., Avigdor Eldar, Liliana Jaso-Friedmann, and Herve Bercovier. Streptococcus Iniae Infection in Trout and Tilapia: Host-Pathogen Interactions, the Immune Response Towards the Pathogen and Vaccine Formulation. United States Department of Agriculture, 2005. http://dx.doi.org/10.32747/2005.7586538.bard.
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The objectives of the BARD proposal were to determine the mechanisms of nonspecific cytotoxic cells (NCC) that are necessary to provide heightened innate resistance to infection and to identify the antigenic determinants in Streptococcus iniae that are best suited for vaccine development. Our central hypothesis was that anti-bacterial immunity in trout and tilapia can only be acquired by combining "innate" NCC responses with antibody responses to polysaccharide antigens. These Objectives were accomplished by experiments delineated by the following Specific Aims: Specific aim (SA) #1 (USA) "Clone and Identify the Apoptosis Regulatory Genes in NCC"; Specific aim #2 (USA)"Identify Regulatory Factors that Control NCC Responses to S. iniae"; Specific aim #3 (Israel) "Characterize the Biological Properties of the S. iniae Capsular Polysaccharide"; and Specific aim #4 (Israel) "Development of an Acellular Vaccine". Our model of S. iniae pathogenesis encompassed two approaches, identify apoptosis regulatory genes and proteins in tilapia that affected NCC activities (USA group) and determine the participation of S.iniae capsular polysaccharides as potential immunogens for the development of an acellular vaccine (Israel group). We previously established that it was possible to immunize tilapia and trout against experimental S. difficile/iniaeinfections. However these studies indicated that antibody responses in protected fish were short lived (3-4 months). Thus available vaccines were useful for short-term protection only. To address the issues of regulation of pathogenesis and immunogens of S. iniae, we have emphasized the role of the innate immune response regarding activation of NCC and mechanisms of invasiveness. Considerable progress was made toward accomplishing SA #1. We have cloned the cDNA of the following tilapia genes: cellular apoptosis susceptibility (CAS/AF547173»; tumor necrosis factor alpha (TNF / A Y 428948); and nascent polypeptide-associated complex alpha polypeptide (NACA/ A Y168640). Similar attempts were made to sequence the tilapia FasLgene/cDNA, however these experiments were not successful. Aim #2 was to "Identify Regulatory Factors that Control NCC Responses to S. iniae." To accomplish this, a new membrane receptor has been identified that may control innate responses (including apoptosis) of NCC to S. iniae. The receptor is a membrane protein on teleost NCC. This protein (NCC cationic antimicrobial protein-1/ncamp-1/AAQ99138) has been sequenced and the cDNA cloned (A Y324398). In recombinant form, ncamp-l kills S. iniae in vitro. Specific aim 3 ("Characterize the Biological Properties of the S.iniae Capsular Polysaccharide") utilized an in- vitro model using rainbow trout primary skin epithelial cell mono layers. These experiments demonstrated colonization into epithelial cells followed by a rapid decline of viable intracellular bacteria and translocation out of the cell. This pathogenesis model suggested that the bacterium escapes the endosome and translocates through the rainbow trout skin barrier to further invade and infect the host. Specific aim #4 ("Development of an Acellular Vaccine") was not specifically addressed. These studies demonstrated that several different apoptotic regulatory genes/proteins are expressed by tilapia NCC. These are the first studies demonstrating that such factors exist in tilapia. Because tilapia NCC bind to and are activated by S. iniae bacterial DNA, we predict that the apoptotic regulatory activity of S. iniae previously demonstrated by our group may be associated with innate antibacterial responses in tilapia.
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Jittapiromsak, Nutchawan. Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging for Determining the Plasma Epstein-Barr Virus Status and Staging of Nasopharyngeal Carcinoma. Faculty of Medicine, Chulalongkorn University, 2019. https://doi.org/10.58837/chula.res.2019.9.
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Objective: To determine the associations between dynamic-contrast enhanced (DCE) magnetic resonance imaging (MRI) parameters and plasma Epstein-Barr virus (EBV) DNA status and nasopharyngeal carcinoma (NPC) stages. Methods: We prospectively studied the DCE MRI results of 47 patients with newly diagnosed NPC and a known pre-treatment plasma EBV DNA level. Regions of interest (ROIs) were drawn at primary tumors, and DCE MRI parameters, including mean and max values of Ktrans, Kep Ve, and Vp, were recorded. Spearman’s rank correlation was used to identify significant associations between DCE MRI parameters and plasma EBV DNA level and NPC stages. Mann-Whitney U tests and unpaired t-test were performed to compare DCE MRI parameters among groups and to find optimal cut-off values using receiver operating characteristic curves. Results: DCE MRI parameters were correlated with plasma EBV DNA levels and NPC stages. Positive plasma EBV DNA was correlated with lower Kepmean (optimal cut-off value, 2.1 min⁻¹ ; area under the curve [AUC], 0.714) and higher Vemax (optimal cut-off value, 0.675; AUC, 0.706). Vemax higher than 0.765 (AUC, 0.678) was correlated with plasma EBV DNA (≥2,300 copies mlll⁻¹). Higher Ktransmax (cut-off value, 1.495 min⁻¹; AUC, 0.767) was correlated with high T stage, and higher Vpmean(cut-off value, 0.125; AUC, 0739) was correlated with positive lymph nodes. Ktransmax higher than 1.495 min⁻¹ (AUC, 0.711) was correlated with the high stage group. Conclusions: DCE MRI is correlated with the plasma EBV DNA status and NPC stages. Therefore, DCE MRI findings may be used as imaging biomarkers for NPC patients.
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Fazekas, Andreas, and Scarleth Nuñez Castillo. NDC Invest Annual Overview 2020. Inter-American Development Bank, 2021. http://dx.doi.org/10.18235/0003430.
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NDC INVEST is an IDB Group platform offering financial solutions and technical support to help build national goals and transform them into attainable plans that generate prosperous, resilient, and carbon neutral economies. Throughout the years closely supporting LAC countries, NDC INVEST has gained valuable experience and knowledge in designing and implementing concrete actions that lead to long-term climate resilience and net-zero emissions by 2050. In 2020, NDC INVEST confirmed its key role in successfully translating national climate commitments into physical and beneficial economic plans and transformational development projects. 331 initiatives have been supported in IDB Group regional member states through the IDB sovereign window, IDB Invest and IDB Lab. This publication highlights the successful work of NDC Invest in i.) developing relevant knowledge and building national capacities for long-term strategies (LTS), ii.) supporting countries in creating ambitious climate goals and NDCs, and iii.) implementing LTS and NDCs through financial strategies and investment plans.
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Junghans, Christoph. ASC/NGC Gitlab Tutorial. Office of Scientific and Technical Information (OSTI), 2016. http://dx.doi.org/10.2172/1257109.
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Williamson, S., and L. Nobile. Transition of Nic Services. RFC Editor, 1991. http://dx.doi.org/10.17487/rfc1261.
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Krivosheev, O. E., N. V. Mokhov, and S. I. Striganov. NLC positron production target. Office of Scientific and Technical Information (OSTI), 1996. http://dx.doi.org/10.2172/214308.
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Raimondi, P. New NLC Final Focus. Office of Scientific and Technical Information (OSTI), 2004. http://dx.doi.org/10.2172/839955.
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