Academic literature on the topic 'NLX-204'

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Journal articles on the topic "NLX-204"

1

Gruca, P., E. Litwa, M. Lason, A. Newman-Tancredi, R. Depoortère, and M. Papp. "Ketamine and the 5-HT1A receptor biased agonists, NLX-204 and NLX-101, share common cortical efficacious rapid acting antidepressant mechanisms in rat cms depression model." Neuroscience Applied 2 (2023): 102777. http://dx.doi.org/10.1016/j.nsa.2023.102777.

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2

Papp, Mariusz, Piotr Gruca, Magdalena Lason, Ewa Litwa, Adrian Newman-Tancredi, and Ronan Depoortère. "The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, display ketamine-like RAAD and anti-TRD activities in rat CMS models." Psychopharmacology, June 13, 2023. http://dx.doi.org/10.1007/s00213-023-06389-5.

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Abstract Objectives NLX-101 and NLX-204 are highly selective serotonin 5-HT1A ‘biased’ agonists, displaying potent and efficacious antidepressant-like activity upon acute administration in models such as the forced swim test. Methods we compared the effects of repeated administration of NLX-101, NLX-204 and ketamine in the chronic mild stress (CMS) model of depression, considered to have high translational potential, on sucrose consumption (anhedonia measure), novel object recognition (NOR; working memory measure) and elevated plus maze (EPM; anxiety measure) in male Wistar and Wistar-Kyoto ra
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Papp, Mariusz, Piotr Gruca, Ewa Litwa, Magdalena Lason, Adrian Newman-Tancredi, and Ronan Depoortère. "The 5-HT1A receptor biased agonists, NLX-204 and NLX-101, like ketamine, elicit rapid-acting antidepressant activity in the rat chronic mild stress model via cortical mechanisms." Journal of Psychopharmacology, June 2, 2024. http://dx.doi.org/10.1177/02698811241254832.

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Background: The highly selective 5-HT1A serotonin receptor “biased” agonists NLX-101 and NLX-204 display, like ketamine, potent and efficacious rapid-acting antidepressant (RAAD) activity in the rat chronic mild stress (CMS) model with systemic (i.p.) administration. They rapidly (within 1 day) reverse anhedonia (i.e., CMS-induced sucrose consumption deficit), attenuate working memory deficit (novel object recognition: NOR), and decrease anxiety behavior in the elevated-plus maze (EPM). Aims: Here, we sought to explore the contribution of prefrontal cortex (PFC) 5-HT1A receptor activation in t
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Richin, Violette, Marco Valdebenito, Caroline Bouillot, et al. "Multimodal Neuroimaging for the PK/PD Profile of NLX-204: A Biased 5-HT1A Receptor Agonist." ACS Chemical Neuroscience, June 30, 2025. https://doi.org/10.1021/acschemneuro.5c00342.

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5

Głuch-Lutwin, Monika, Kinga Sałaciak, Karolina Pytka, et al. "The 5-HT1A receptor biased agonist, NLX-204, shows rapid-acting antidepressant-like properties and neurochemical changes in two mouse models of depression." Behavioural Brain Research, November 2022, 114207. http://dx.doi.org/10.1016/j.bbr.2022.114207.

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