Academic literature on the topic 'NMRD'

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Journal articles on the topic "NMRD"

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Lommens, Petra, Pieter Tack, Luce Vander Elst, Isabel Van Driessche, Laszlo Vincze, and Davy Sinnaeve. "Spectroscopy as a tool to detect multinuclear Cu(ii)–triethanolamine complexes in aqueous solution." Dalton Transactions 47, no. 11 (2018): 3755–63. http://dx.doi.org/10.1039/c7dt04146b.

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The Evans method, Extended X-ray Absorption Fine Structure (EXAFS) and NMR relaxation dispersion (NMRD) spectroscopy were used to prove the existence of multimeric Cu(ii)–triethanolamine species in aqueous solutions.
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Fries, Pascal H., Johannes Richardi, Sebastian Rast, and Elie Belorizky. "Theories of structural and dynamic properties of ions in discrete solvents. Application to magnetic resonance imaging." Pure and Applied Chemistry 73, no. 11 (January 1, 2001): 1689–703. http://dx.doi.org/10.1351/pac200173111689.

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The molecular Ornstein­Zernike (MOZ) formalism used to compute the structure of a liquid solution is briefly presented. Its ability to describe the equilibrium properties of aprotic solvents and of their electrolyte solutions is demonstrated from selected examples. The potential of mean force and the relative motion of ions in water are studied by the powerful method of intermolecular nuclear magnetic relaxation dispersion (NMRD) in paramagnetic solutions. The interest of the ion­ion dynamics in medical magnetic resonance imaging (MRI) is shown by a typical NMRD study involving paramagnetic gadolinium Gd3+ complexes.
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Murray, E., and D. F. Brougham. "NMRD of polyaniline-based conducting polymers." Synthetic Metals 155, no. 3 (December 2005): 681–83. http://dx.doi.org/10.1016/j.synthmet.2005.06.022.

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Neugebauer, Petr, Jan G. Krummenacker, Vasyl P. Denysenkov, Christina Helmling, Claudio Luchinat, Giacomo Parigi, and Thomas F. Prisner. "High-field liquid state NMR hyperpolarization: a combined DNP/NMRD approach." Phys. Chem. Chem. Phys. 16, no. 35 (2014): 18781–87. http://dx.doi.org/10.1039/c4cp02451f.

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Dynamic nuclear polarization and NMR relaxation dispersion measurements have been performed on liquid solutions of TEMPOL radicals in solvents with different viscosities at a high magnetic field of 9.2 T. The results indicate that fast dynamics significantly contribute to DNP enhancements at high fields.
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Banci, Lucia, Ivano Bertini, and Claudio Luchinat. "Solvent 1H NMRD of copper(II) complexes." Chemical Physics Letters 118, no. 3 (July 1985): 345–47. http://dx.doi.org/10.1016/0009-2614(85)85328-8.

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Tenneti, Pavan, Jiaxian He, Brittany Knick Ragon, Nilay A. Shah, Jing Ai, Aleksander L. Chojecki, Thomas G. Knight, et al. "Acute Myeloid Leukemia Patients in Complete Remission with Positive Measurable Residual Disease Prior to Allogeneic Transplant Have Worse Outcomes, Similar to Active Disease Regardless of Conditioning Regimen Intensity and Post-Transplant Cyclophosphamide Administration." Blood 138, Supplement 1 (November 5, 2021): 4907. http://dx.doi.org/10.1182/blood-2021-154011.

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Abstract Introduction Allogenic hematopoietic cell transplant (HCT) for acute myeloid leukemia (AML) is a curative option in patients with intermediate/high risk disease who achieve morphologic complete remission (CR) after induction chemotherapy. Patients in CR but with positive measurable residual disease (pMRD) prior to HCT had high relapse risk(RR) (67% vs 65%) and low 3 year overall survival (OS) (26% vs 23%),similar to those with active disease in a single institution study (Araki et.al; Volume 34, Feb 1,2016, JCO). However, this study included only patients who received myeloablative conditioning (MAC) and included both peripheral blood and marrow grafts. A single institution retrospective study showed that use of MAC compared to reduced intensity conditioning (RIC) improved 3 year RR(19% v 67%; P < .001) and OS( 61% v 43%; P = .02) in patients with pMRD/CR(determined by molecular analysis of limited gene mutational panel)(Hourigan et.al. Volume 38, April 20,2020, JCO). We analyzed a cohort of AML patients that underwent either MAC or RIC followed by peripheral blood stem cell grafts and post-transplant cyclophosphamide (PTCy) based GVHD prevention regimen at our institution to determine the effect of pMRD on transplant outcomes. Methods: To evaluate the impact of pMRD on transplant outcomes, we analyzed AML patients who underwent HCT at Levine Cancer Institute between June 2014 and April 2020 with MRD testing performed within 1 month prior to HCT. MRD testing was performed at University of Washington by using multiparametric flow cytometry (MPC). The overall sensitivity of the assay is conservatively estimated as 0.1%. In our institution, all patients received MAC (Bu/Flu) or RIC (Bu/Flu or Flu/Cy/TBI) regimens followed by peripheral blood stem cell grafts and identical PTCy-based GVHD prophylaxis regimens that included tacrolimus and mycophenolate. Patient and transplant related characteristics were presented via descriptive statistics. Corresponding P-values were determined using Fisher's exact test for categorical variables and nonparametric Mann-Whitney U test for continuous variables. Relapse-free survival (RFS) and OS were estimated using the Kaplan Meier method. All statistical tests were two sided, and a P-value < 0.05 was considered statistically significant. Results From June 2014 to April 2020, 105 patients with AML underwent HCT. Eighty-three patients with MRD results were included in the final analysis - 52 (63%) with negative MRD (nMRD)/CR, 16 (19%) with pMRD/ CR and 15 (18%) with active disease (no CR). Baseline characteristics were similar except for presence of significantly greater number of high risk patients, based on ASTCT disease classification in the active disease group compared to pMRD/CR and nMRD/CR cohorts( 87% vs 19% vs 0%, P =< 0.001). Median follow up for the entire cohort was 32.7 months. RFS was superior in patients with nMRD/ CR compared to pMRD/ CR or active disease (56.4% vs 19.4% vs 35%, P= 0.005). In addition, OS was superior in nMRD/ CR compared to pMRD/CR or active disease (56.7% vs 35.2% vs 40%, P= 0.014). The use of MAC compared to RIC did not improve RFS (0% vs 32%, P= 0.018) and OS (0% vs 44%, P= 0.071) in pMRD/CR cohort. The use of MAC or RIC did not significantly impact RFS (69% vs 52%, P=0.729) or OS (61% vs 53%, P=0.739) in nMRD/CR patients. Conclusion: Our study validates the previous data that prognosis of patients with pMRD/CR (determined by MPC) prior to HCT is not significantly better than those having active disease. The outcomes were poor regardless of conditioning regimen intensity and PTCy based GVHD prophylaxis used at our institution. These patients might benefit from additional chemotherapy or targeted treatments to achieve nMRD prior to HCT and/or maintenance therapy post HCT. Patients with nMRD/CR disease had similar outcomes with MAC or RIC. This finding suggests that less aggressive conditioning regimens incorporating PTCy could be considered in a subset of patients with nMRD/CR, thereby sparing them from complications associated with MAC. Prospective trials are needed to further study these findings. Figure 1 Figure 1. Disclosures Copelan: Amgen: Consultancy. Grunwald: Astellas: Consultancy; Karius: Consultancy; PER: Other; Gilead: Consultancy; Incyte: Consultancy, Research Funding; Amgen: Consultancy; PRIME: Other; Daiichi Sankyo: Consultancy; Bristol Myers Squibb: Consultancy; AbbVie: Consultancy; Trovagene: Consultancy; Stemline: Consultancy; Pfizer: Consultancy; Janssen: Research Funding; Blueprint Medicines: Consultancy; Sierra Oncology: Consultancy; Med Learning Group: Other; Cardinal Health: Consultancy; MDEdge: Other; Agios: Consultancy.
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Peña, Angela María, Sandra Vanesa Rios, Luis Antonio Salazar, Manuel Rosales, Sara Ines Jimenez, Katherinee Morales-Chacon, Carlos Alberto Orozco Oviedo, et al. "Clinical Features and Survival According to Minimal Residual Disease in a Colombian Population Diagnosed with B-Cell Acute Lymphoblastic Leukemia." Blood 138, Supplement 1 (November 5, 2021): 4459. http://dx.doi.org/10.1182/blood-2021-153874.

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Abstract Introduction Acute lymphoblastic leukemia (ALL) is a clonal hematopoietic disorder that originates from B or T lymphoid progenitors and has well validated prognostic and predictive factors that influence outcomes. One of the strongest prognostic factors is the detection of minimal residual disease (MRD) which measures residual cell population after treatment when a morphologic complete response has been achieved. MRD positivity is associated with a higher risk of relapse and poor response to chemo or radiotherapy Objectives The aim of the study was to assess the prognostic impact of post-induction MRD status in a cohort of ALL Colombian patients in terms of relapse-free survival (RFS) and overall survival (OS). Methods This is a retrospective observational study conducted at a Colombian university hospital and included a cohort of ALL patients diagnosed between 2013 and 2020 treatment according to protocol PETHEMA (Spanish Program for Hematology Treatments). MRD was measured with 8-color flow cytometry evaluate on bone marrow. MRD status was classified as negative MRD (NMRD) or positive MRD (PMRD) based on a sensitivity threshold of <0,01% or ≥0,01% leukemic cells, respectively, following to international guides. Demographic and clinical characteristics were analyzed using descriptive statistics. Kaplan-Meier method was used to assess overall RFS and OS. Results A total 128 patients were included. The median age at diagnosis was 34 years (range 0-89 years), 54% were men, 26% were overweight, 22% obese, 6.2% had type 2 DM (T2DM), and most had a ECOG PS of £2 (94%). Most patients (80.5%) had high risk according PETHEMA, B-ALL and were classified as ALL-2 (58%) according to FAB classification with Pre-B cell ALL being the most common phenotype (54.7%). Ph+ ALL was diagnosed in 12% of patients. Most used treatments protocols were PETHEMA-AR and PETHEMA-RI in 43.8% and 11.6% of patients, respectively. Post-induction MRD measurement was available in 98 patients, 36 (36.7%) had NMRD and 62 (63.3%) PMRD. From the 36 patients with NMRD, eight patients (22.2%) received Allogeneic Hematopoietic Stem Cell Transplantation (alloHSCT): two of them, were transplanted in first complete remission, one because of high risk and the other one for BCR-ABL positivity. The other six patients received alloHSCT in second remission and all of them relapsed after late consolidations. Finally, alloHSCT was done in 28 patients with PMRD (45.2%). The 12-month OS for patients with NMRD was 68.7% (95%CI 50.5-81.2) compared to 63.7% (95%CI 50.3-74.4) in the ones with PMRD, p=0.375. 12-month RFS was 83.3% (95%CI 61.5-93.4) in patients with NMRD and 90.0% (95%CI 72.1-96.7) in patients with PMRD, p=0.436. (Figure 1). OS was significantly higher for the PMRD patients who underwent AlloHSCT 96.4% (95%CI 77.2-99.4) versus not underwent 36.8% (95%CI 20.6-53.2), HR: 0.39 (95%CI 0.005-0.29) p=0.002 (Figure 2). Conclusion MRD assessment is a strong prognostic in ALL, however it was not associated with significant differences in RFS or OS in this single institution cohort of Colombian patients. Patients with PMRD taken to AlloHSCT had superior OS compared to NMRD that underwent transplant. A small sample size and short follow-up could explain our results. Larger cohorts with extended follow up and with different MRD methods are needed to better understand the role of MRD assessment in minority ALL populations, such as Colombian patients. Figure 1 Figure 1. Disclosures Peña: Amgen: Research Funding. Salazar: Amgen: Research Funding. Sandoval-Sus: BMS: Other: Advisory Board, Speakers Bureau; SeaGen, Janssen, MassiveBio, TG: Other: Advisory Board. Sossa: Amgen: Research Funding.
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Bertini, Ivano, Parvana Hajieva, Claudio Luchinat, and Kirill Nerinovski. "Redox-Dependent Hydration of Cytochromecand Cytochromeb5Studied through17O NMRD." Journal of the American Chemical Society 123, no. 51 (December 2001): 12925–26. http://dx.doi.org/10.1021/ja0163624.

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FOSSHEIM, SIGRID L., MARGA SPILLER, and KENNETH E. KELLAR. "NMRD Investigation of DyDTPA- and GdDTPA-Labeled Starch Particles." Investigative Radiology 34, no. 4 (April 1999): 287. http://dx.doi.org/10.1097/00004424-199904000-00006.

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Bertini, Ivano, Zhicheng Xia, and Claudio Luchinat. "Solvent water1H NMRD study of oxovanadium(IV) aquo ion." Journal of Magnetic Resonance (1969) 99, no. 2 (September 1992): 235–46. http://dx.doi.org/10.1016/0022-2364(92)90174-6.

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Dissertations / Theses on the topic "NMRD"

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Zhou, Xiangzhi. "An Analysis of NMRD profiles and ESR lineshapes of MRI Contrast Agents." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-361.

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Huang, Yang. "Analysis of NMR Spin-lattice Relaxation Dispersion on Complex Systems." Doctoral thesis, Umeå universitet, Kemiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-110721.

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This thesis focus on the analysis of spin-lattice NMRD relaxation profilesmeasured in various complex systems such as proteins, zeolites and ionicliquids. Proton, deuterium and fluoride T1-NMRD relaxation profiles wereobtained from a fast-field cycling (FFC) instrument. It is found that alsopossible to obtain NMRD profiles from the molecular dynamics (MD)simulation trajectories. NMRD Profiles were analyzed by using differentrelaxation models, such as the Solomon-Bloembergen-Morgan (SBM) theoryand the Stochastic Liouville (SL) theory. Paper I described the hydration of protein PrxV obtained from a MDsimulation, and compared with the picture emerges from an analysis byusing a generally accepted relaxation model [appendix C]. The result showsthat the information from NMRD analysis is an averaged picture of watermolecules with similar relaxation times; and the MD simulations containsinformation of all types of interested water molecules with differentresidence times. In paper II NMRD profiles have been used to characterize the hydration ofthe oxygen-evolving complex in state S1 of photosystem II. NMRDexperiments were performed on both intact protein samples and Mndepletedsamples, and characteristic dispersion difference were foundbetween 0.03 MHz to 1 MHz; approximately. Both the SBM theory and theSL theory have been used to explain this dispersion difference, and it isfound that this is due to a paramagnetic enhancement of 1-2 water moleculesnearby ~10 Å from the spin center of the Mn4CaO5 cluster. The result showsthe reorientation of the molecular cluster is in μs time interval. Whencompare these two theories, the SL theory presented a better interpretationbecause parameters obtained from the SBM theory shows they didn’t fulfilthe presupposed perturbation criterion (the Kubo term). Paper III deals with the water dynamics in the restricted/confined spaces inthe zeolite samples (H-ZSM-5 and NH4-ZSM-5) and obtained by proton anddeuterium spin-lattice NMRD profiles. The results show that the spin-latticeNMRD can be used to characterize various zeolites. The temperature has aweak effect on the relaxation rate R1, but the change of different counter ionsmay change the hydration and the translational diffusion pores and givedifferent R1. Proton and fluoride NMRD profiles and MD simulations were both used tostudy the dynamics of BMIM[PF6] in paper IV. Results indicate the reorientation of the molecules are in the ns time regime, and the effectivecorrelation time obtained from 1H and 19F are the same. From the MDsimulation it is found the reorientation of [PF6]- ions is much faster (in ps)compare with BMIM+ ion which moves in the ns time range. With previous results, the FFC NMRD profiles are indeed very informativetools to study the molecular dynamics of complex systems. The MDsimulation can be used as a complementary method to obtain detailedinformation. By combine these two methods, it provide a more colorfulpicture in the study of protein hydration and liquid molecular dynamics.
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Pedacchia, Marta. "Rilassometria NMR per lo studio degli ioni cobalto nel cobaltismo da artroprotesi." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2015. http://amslaurea.unibo.it/8330/.

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Il rilascio di detriti d’usura metallici è una grave problematicità connessa ai sistemi protesici, e principalmente riguarda le protesi d’anca ad accoppiamento metallo su metallo in lega CoCr. La presenza di un livello di ioni Co nel siero che supera la soglia di tossicità è correlata a metallosi periprotesica eal fallimento del l’impianto. Recentemente è emersa un’altra casistica, presumibilmente connessa alla distribuzione e accumulo di questi ioni in tessuti di organi anche lontani dall’impianto, che si manifesta con una sintomatologia sistemica analoga a casi noti di avvelenamento da Cobalto. Nel contesto di questa nuova patologia sarebbe di grande interesse la possibilità di monitorare in-vivo la distribuzione del Cobalto rilasciato da protesi articolari, in organi o tessuti di pazienti che manifestano alti ivelli ionici di Co nel siero utilizzando metodiche non invasive come l’NMR. L’ipotesi sperimentale di applicabilità prende spunto dalle proprietà magnetiche che alcuni composti del Cobalto possono presentare nell’organismo. In questo lavoro sperimentale, nato dalla collaborazione tra il laboratorio NMR del DIFA dell’Università di Bologna e l’Istituto Ortopedico Rizzoli (IOR) di Bolgna, si presentano i risultati relativi allo studio di fattibilità condotto con diverse metodiche di rilassometria NMR su campioni biologici in presenza di Co. L’obiettivo riguarda la caratterizzazione delle proprietà di rilassamento con elettromagnete a temperatura ambiente e fisiologica, e la valutazione delle dinamiche molecolari dai profili NMRD ottenuti alle basse frequenze con metodica Fast Field Cycling, dei nuclei 1H di tali sistemi in presenza di Co.
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Hoffmann, Dirk. "NMR-Untersuchungen an Nanokapsel-Dispersionen - NMR investigations on nanocapsule dispersions." Gerhard-Mercator-Universitaet Duisburg, 2001. http://www.ub.uni-duisburg.de/ETD-db/theses/available/duett-05302001-102514/.

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Nanocapsules are generally considered as spherical, hollow structures. Important potential applications are pharmaceutically related such as drug targeting and controlled release. Typically, the capsules consist of a polymeric wall, filled with an oil which can dissolve lipophilic agents. To enable a stable aqueous dispersion, the capsule surface is covered by an amphiphilic surfactant. Nanocapsule-dispersions were investigated by means of solid-state nmr. Cross polarization experiments revealed the morphology of the polymeric wall. Further, the spin-lattice relaxation times for the proton magnetization in the rotating frame were studied under direct excitation as well as under cross polarization conditions. Based on the results, a special mechanism of cross polarization is proposed, initiated by a temporary adsorption of mobile oil- and surfactant-molecules to the more rigid capsule surface. - Nanokapseln sind sphärische, hohle Objekte, die in der Medizin als gewebespzifische Wirkstoff-Träger-Systeme eingesetzt werden sollen. Vereinfacht bestehen die Kapseln aus einem Öltropfen, der von einem Polymergerüst umgeben ist. In die innere Ölphase können lipophile Wirkstoffe eingeschlossen werden. Die Nanokapselwand ist mit einer Tensidschicht umgeben, die stabilisierend wirkt und ermöglicht, dass die Kapseln in einer wässerigen Phase dispergiert werden können. Als analytische Methode wurde die Festkörper-NMR-Spektroskopie gewählt. Die Morphologie der Polymerwand wurde mit Kreuzpolarisationsexperimenten aufgeklärt. Zusätzlich wurden die Relaxationszeiten im rotierenden Koordinatensystem der Protonen unter Direktanregungs- und Kreuzpolarisationsbedingungen untersucht. Die Ergebnisse dieser Untersuchungen konnten mit einer temporären Adsorption der Öl- und Tensidmoleküle an der Nanokapseloberfläche interpretiert werden.
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Lenz, Eva-Maria. "Multinuclear NMR and HPLC-NMR spectroscopic studies on xenobiotic metabolism." Thesis, Birkbeck (University of London), 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.267785.

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Lee, Jaehyuk. "A portable NMR." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609637.

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Karvonen, V. (Ville). "NMR-spektroskopia lääkeaineanalytiikassa." Bachelor's thesis, University of Oulu, 2017. http://urn.fi/URN:NBN:fi:oulu-201705232041.

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NMR-spektroskopia perustuu ytimien ydinmagnettisen resonanssin mittaamiseen. Menetelmä on kasvattanut suosiotaan lääkeaineanalytiikassa aina ilmiön löytämisestä lähtien. Tässä tutkielmassa perehdytään NMR-spektroskopian teoriaan ja sen käyttöön lääkeaineanalytiikassa, jossa NMR-menetelmä tulee päivä päivältä tärkeämmäksi ja yleisemmäksi. NMR-spektroskopia on nopea, informatiivinen, eikä kalliiden tai monimutkaisten standardien käyttö ole menetelmässä tarpeellista. Menetelmää voidaan periaatteessa soveltaa kaikille ydinaktiivisille ytimille, mutta yleisimmin menetelmällä mitataan 1H-ydintä.
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Norris, David G. "NMR flow imaging." Thesis, University of Aberdeen, 1986. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU009818.

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The phase-encoded method of NMR flow imaging is examined in detail. The motion of isochromatic groups in the direction of suitably balanced magnetic field gradients will give a phase change in the NMR signal directly proportional to the velocity, acceleration, or higher derivative of position, dependent upon the form of the field gradient. If a simple bipolar pulse is used then the phase change, for isochromats moving with constant velocity, will be proportional to the velocity. If two such pulses are placed back to back then the phase change is proportional to the acceleration. The motion of isochromats in the magnetic field gradients used for imaging will also cause phase changes. These effects are considered, and simple methods of reducing them presented. Phase errors due to main field inhomogeneity are shown to be eliminated by a simple phase difference technique. In this two image data sets having different flow sensitivities are obtained, and the phase difference between them calculated. Velocity images were obtained using this technique, both by the manipulation of the frequency-encoding and selection gradients, and by the insertion of bipolar pulses in the imaging sequence. Acceleration images were also produced by adding double bipolar pulses to the imaging sequence. Both spin-echo and field-echo sequences were used. Field-echo sequences were shown to be superior for high velocities, particularly when the direction of flow is through the slice, otherwise spin-echo sequences were preferred. The Fourier imaging of velocity is also examined, and images presented. This technique is only considered to be useful for projective imaging, where it is shown to have an SNR advantage over established methods. Using two specially designed phantoms the accuracy of all these techniques is shown to be within 5%.
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Vuorinen, J. (Jere). "Maaperänäytteiden NMR-analyysi." Bachelor's thesis, University of Oulu, 2018. http://urn.fi/URN:NBN:fi:oulu-201812183292.

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Tässä tutkielmassa olemme kiinnostuneita miten NMR-spektroskopiaa voidaan käyttää maaperänäytteiden tutkimiseen. Maaperässä on erilaisia hiiliyhdisteitä ja niitä voidaan havaita kiinteän aineen 13C NMR-spektroskopialla. Tutkielmassa käydään läpi perinteisen NMR:n ja kiinteän aineen NMR:n perusasioita. Lopuksi perehdytään maaperänäytteiden tutkimiseen.
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Sarala, J. (Jouni). "Low field NMR." Bachelor's thesis, University of Oulu, 2019. http://jultika.oulu.fi/Record/nbnfioulu-201907252707.

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Abstract. The subject of this thesis is NMR in low magnetic field. Traditionally NMR instruments utilize a superconducting high field magnet, but recently, compact instruments are getting more common with the use of lower magnetic fields. In this thesis, the basic theory of NMR is explained and the instrumentation and different ways of producing homogeneous magnetic fields are described. An experimental set-up was constructed and tested. The theory of relaxation and dependence of resonance frequency on the magnetic field were demonstrated.
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Books on the topic "NMRD"

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NMD yu fan zhi NMD. Beijing: Guo fang da xue chu ban she, 2001.

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Kimmich, Rainer. NMR. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6.

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Silva Elipe, Maria Victoria. LC-NMR and Other Hyphenated NMR Techniques. Hoboken, NJ, USA: John Wiley & Sons, Inc., 2011. http://dx.doi.org/10.1002/9781118135396.

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Iwashita, Takashi. NMR rittai kagaku: Tokuron = NMR stereo chemistry. Tōkyō: Kōdansha, 2012.

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author, Haber-Pohlmeier Sabina 1962, and Zia Wasif author, eds. Compact NMR. Berlin: Walter de Gruyter GmbH & Co. KG, 2014.

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Blümich, Bernhard. Essential NMR. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-10704-8.

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Ghose, Ranajeet, ed. Protein NMR. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7386-6.

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Mason, Joan, ed. Multinuclear NMR. Boston, MA: Springer US, 1987. http://dx.doi.org/10.1007/978-1-4613-1783-8.

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Berliner, Lawrence, ed. Protein NMR. Boston, MA: Springer US, 2015. http://dx.doi.org/10.1007/978-1-4899-7621-5.

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Gunther, Harald. NMR spectroscopy. 2nd ed. Chichester: Wiley, 1994.

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Book chapters on the topic "NMRD"

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Bertini, Ivano, Fabrizio Briganti, and Claudio Luchinat. "Solvent Proton Nuclear Magnetic Relaxation Dispersion (NMRD) in Solutions of Paramagnetic Macromolecules." In Advanced Magnetic Resonance Techniques in Systems of High Molecular Complexity, 165–95. Boston, MA: Birkhäuser Boston, 1986. http://dx.doi.org/10.1007/978-1-4615-8521-3_16.

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Kimmich, Rainer. "Introductory Remarks." In NMR, 3–6. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_1.

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Kimmich, Rainer. "Spin-Relaxation Functions." In NMR, 90–96. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_10.

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Kimmich, Rainer. "Perturbation Theory of Spin Relaxation." In NMR, 97–101. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_11.

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Kimmich, Rainer. "Spin-Lattice Relaxation." In NMR, 102–15. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_12.

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Kimmich, Rainer. "Transverse Relaxation." In NMR, 116–24. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_13.

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Kimmich, Rainer. "Examples of Autocorrelation Functions." In NMR, 125–37. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_14.

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Kimmich, Rainer. "Field-Cycling NMR Relaxometry." In NMR, 138–48. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_15.

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Kimmich, Rainer. "Field-Cycling Relaxometry in Biosystems." In NMR, 149–58. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_16.

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Kimmich, Rainer. "The Dipolar-Correlation Effect." In NMR, 159–74. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-60582-6_17.

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Conference papers on the topic "NMRD"

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Sun, Nan, Tae-Jong Yoon, Hakho Lee, William Andress, Vasiliki Demas, Pablo Prado, Ralph Weissleder, and Donhee Ham. "Palm NMR and one-chip NMR." In 2010 IEEE International Solid- State Circuits Conference - (ISSCC). IEEE, 2010. http://dx.doi.org/10.1109/isscc.2010.5433836.

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Gomes, Matheus G. R., Hélio F. dos Santos, and Diego F. S. Paschoal. "Predicting Co-59 NMR Chemical Shit using the NMR-DKH Basis Sets." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020179.

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The cobalt-59 nucleus is an NMR active nucleus with the nuclear spin I = 7/2 and has a natural abundance of 100 %. It is an important nucleus because it has ease of detectable NMR signals both liquid and solid-state. The Co-59 NMR chemical shift range is one of the largest known in NMR spectroscopy, spanning some 18,000 ppm or more. However, Co-59 NMR is an extremely sensitive technique to external factors such as pressure, temperature, and others. Therefore, predicting Co-59 NMR chemical shift might be useful to assist experimentalists in the structural characterization. In the present study, we propose a new NMR-DKH basis set for Co atom to predict NMR chemical shift in Co complexes. Besides, we proposed a computational protocol (Functional DFT/Co basis set/Ligands basis set) for the prediction of the structure and, later, for the prediction of the Co-59 NMR chemical shift using 6 Co complexes as model systems. The results show that the computational protocol (NMR/structure) GIAO-B3LYP/NMR-DKH/IEF-PCM(UFF)//CAM-B3LYP/LANL2DZ/jorge-DZP/IEF-PCM(UFF) presents a mean relative deviation (DRM) of 1.48% for the structure, a mean absolute deviation (MAD) of 101 ppm and a DRM of 1.2% for the Co-59 chemical shift. Finally, the protocol was corrected by a linear regression model giving a MAD and MRD of 57 ppm and 0.7%, respectively.
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Morawitz, Falk. "Multilayered Narration in Electroacoustic Music Composition Using Nuclear Magnetic Resonance Data Sonification and Acousmatic Storytelling." In ICAD 2019: The 25th International Conference on Auditory Display. Newcastle upon Tyne, United Kingdom: Department of Computer and Information Sciences, Northumbria University, 2019. http://dx.doi.org/10.21785/icad2019.052.

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Nuclear magnetic resonance (NMR) spectroscopy is an analytical tool to determine the structure of chemical compounds. Unlike other spectroscopic methods, signals recorded using NMR spectrometers are frequently in a range of zero to 20000 Hz, making direct playback possible. As each type of molecule has, based on its structural features, distinct and predictable features in its NMR spectra, NMR data sonification can be used to create auditory ‘fingerprints’ of molecules. This paper describes the methodology of NMR data sonification of the nuclei nitrogen, phosphorous, and oxygen and analyses the sonification products of DNA and protein NMR data. The paper introduces On the Extinction of a Species, an acousmatic music composition combining NMR data sonification and voice narration. Ideas developed in electroacoustic composition, such as acousmatic storytelling and sound-based narration are presented and investigated for their use in sonification-based creative works.
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Wrachtrup, J. "Nanoscale NMR." In Diamond Photonics - Physics, Technologies and Applications. Washington, D.C.: OSA, 2019. http://dx.doi.org/10.1364/dp.2019.121.

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Blümich, Bernhard, Federico Casanova, Ernesto Danieli, Qingxia Gong, Marcus Greferath, Agnes Haber, Jürgen Kolz, et al. "Moving NMR." In MAGNETIC RESONANCE IN POROUS MEDIA: Proceedings of the 9th International Bologna Conference on Magnetic Resonance in Porous Media (MRPM9), including 8th Colloquium on Mobile Magnetic Resonance (CMMR8). AIP, 2008. http://dx.doi.org/10.1063/1.3058542.

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Su, Haw-Lih, Rajeesha Rajan, Yousef Mohammad Hijji, Mohammad Ibrahim Ahmad Ibrahim, and Mohammed Hussain S. A. Alsafran. "Detecting Organic Nitrogen with 1H-15N HMBC Spectra." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2021. http://dx.doi.org/10.29117/quarfe.2021.0038.

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NMR spectroscopy has been the most important tool for organic chemistry research, providing detailed structure information. While 1H and 13C NMR spectra were frequently measured, 15N NMR spectra were relatively rare, even though nitrogen is commonly observed in organic molecules. This is due to the low gyromagnetic ratio and nature abundance. Usually 15N NMR spectra are observed when the sample is in very high concentration or the nitrogen is enriched with 15N isotope. HMBC is one of the 2D NMR techniques, measuring the through-bond correlations inside a molecule. 1H-15N HMBC actually collects a series of measurements of 1H NMR spectra with 15N information. Therefore, HMBC could get stronger signals than 15N signals and provide the opportunity for the indirect measurement of 15N signals.
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Shao, Wei, Songhua Chen, Gabor Hursan, and Shouxiang Ma. "Temperature Dependence of NMR Relaxation Time in Carbonate Reservoirs." In SPE Annual Technical Conference and Exhibition. SPE, 2021. http://dx.doi.org/10.2118/206184-ms.

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Abstract NMR-based carbonate interpretation models are commonly calibrated using laboratory ambient core NMR measurements. For applying the core calibrated models to downhole NMR logging interpretation, the difference between the NMR responses measured at ambient and reservoir conditions needs to be evaluated. The temperature dependence of NMR relaxation time in high-quality carbonate reservoirs was investigated, and NMR temperature dependence models were determined using data analytic methods (Hursan et al, 2019). This paper focuses on temperature dependence of NMR relaxation time in low-quality carbonate formations. For more than 95% of the samples investigated, NMR relaxation time shows a positive correlation with temperature. The correlation is similar to that observed in high-quality carbonate rocks but slightly less significant. Temperature dependent correlations for predicting T2GM from a measured temperature to any other temperature are derived from high- and low-quality carbonate rocks independently first, then a unified T2GM correlation is derived including both the high- and low-quality carbonate reservoirs. Predicting T2 distribution from one temperature to other temperatures is achieved using dimension reduction approach involving principal component analysis (PCA) technique. It is found that the T2 distributions at any given temperature for both the high- and low-quality carbonate reservoirs can be predicted robustly from the T2 distributions at the ambient temperature by representing the T2 distributions with principal components (PCs) at the ambient temperature then using these PCs to predict the PCs at a different temperature. The optimal number of PC components depends on the multimodality of the T2 distribution. This work extends the validity range of a data analytic method that quantifies the temperature dependence of carbonate NMR properties. The new NMR temperature model enables the integration of NMR laboratory studies and dowhole measurements for advanced petrophysical analyses in a wide range of carbonate reservoirs.
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Paschoal, Diego F. S., and Joyce H. C. e. Silva. "Relativistic prediction of Pt-195 NMR chemical shift using the NMR- DKH basis sets." In VIII Simpósio de Estrutura Eletrônica e Dinâmica Molecular. Universidade de Brasília, 2020. http://dx.doi.org/10.21826/viiiseedmol2020184.

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Nuclear magnetic resonance (NMR) spectroscopy has played an important role in the discovery and design of new drugs with antitumor potential and the Pt-195 NMR has a fundamental role since the Pt-195 nucleus is very sensitive to the nature of the ligands in the coordination sphere and the oxidation state of the metal. The theoretical prediction of the Pt-195 NMR chemical shift is an extremely difficult task in which several factors must be taken into accounts, such as basis sets, electronic correlation, solvent, and relativistic effects. In an earlier study, Paschoal et al. developed the NMR-DKH basis sets and a nonrelativistic protocol for predicting the Pt-195 NMR chemical shift. The authors studied a set of 258 Pt(II) complexes and obtained a mean absolute deviation (MAD) of 168 ppm and a mean relative deviation (MRD) of 5%. However, relativistic calculations with the NMR-DKH basis sets have not been performed. Thus, the present work aims to apply the NMR-DKH in predicting the Pt-195 NMR chemical shift including the relativistic effects. The cisplatin was used as a model and its geometry was optimized and characterized as a minimum point on the potential energy surface at the B3LYP/LANL2DZ/def2-SVP/COSMO level. The Pt-195 NMR chemical shift was calculated at the DFT-Functional-DKFull/NMR-DKH/COSMO, where the functionals BP86, PBE, BLYP, PBE0, and B3LYP were tested. All calculations were carried out in NWCHEM 7.0.0 program. From the calculated results, it can be observed that the pure GGA functionals showing a better performance when compared to the hybrid functional. The best result was obtained at the BLYP-DKFull/NMR-DKH/COSMO level, where a DAM and DRM of only 34 ppm and 1.6% was found.
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Xie, Z. Harry, Thomas Gentzis, and Humberto Carvajal-Ortiz. "MEASURING KEROGEN, SOLID ORGANICS, AND OIL PRODUCTION POTENTIALS OF UNCONVENTIONAL SOURCE ROCKS USING SOLID TYPE 20-MHZ NMR TECHNIQUES." In 2021 SPWLA 62nd Annual Logging Symposium Online. Society of Petrophysicists and Well Log Analysts, 2021. http://dx.doi.org/10.30632/spwla-2021-0094.

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It is well known that the NMR relaxation time T2 is proportional to the molecular mobility of water or hydrocarbons in rocks. In unconventional tight rocks, water and hydrocarbons are trapped in small pores of nanometer sizes, and their molecular mobility is severely restricted, causing the NMR T2 to be much shorter than that of conventional cases where pore sizes are in micrometer ranges. There are demands for advanced NMR techniques to study those solid-like bound hydrocarbons. In the meantime, it is of great interest for petrophysicists and geochemists to understand kerogen models in order to determine thermal maturity and hydrocarbon potential of organic-rich source rocks, and always attractive to have practical techniques that are nondestructive and less time consuming. In this study, a series of NMR 1D and 2D experiments have been performed on various types of source rocks with emphasis on short NMR T2 components, from sub-milliseconds down to a few microseconds, which are associated with kerogen, heavy hydrocarbons, and small hydrocarbon molecules bound in nanopores. The results show that the NMR CPMG pulse sequence used for the T2 data acquisition is (1) not capable of detecting and measuring the very rigid solid component of the T2 shorter than 30 microseconds, which is thought from kerogen, and (2) uncertain for the NMR components with T2 between 30 microseconds and 0.1 ms, which is dependent on the inter-echo spacing time (TE). Instead, the solid echo-pulse sequence was used to acquire the early time NMR signals that represent rigid solid matters, such as kerogen, in rock samples that have short relaxation times of less than 20 microseconds. The NMR solid echo signals were fitted into a composition of a Gaussian plus exponential functions to better describe NMR responses of source rocks with the shortest relaxation time of a few microseconds. The Gaussian component in the NMR signal is the measure of rigid solids associated with kerogen in the source rock. Model rock samples of thermally immature outcrops of the Upper Jurassic Kimmeridge Clay Formation in the UK and the Green River Shale Formation in the USA were used for comparison studies between the low field solid NMR techniques and geochemical analytical methods. The thermal maturities of the samples were artificially altered through the hydrous pyrolysis method at selected temperatures. The comparison results show that the amplitude of the Gaussian component measurement by NMR strongly correlated with the S2 of pyrolysis. The NMR relaxation times of the solid portion are directly proportional to the thermal maturity determined by organic petrography. This study concludes that the nondestructive solid NMR method provides an alternative and rapid way to study solid organic matters. The combined techniques enable us to further study kerogen models and hydrocarbon-generating potentials in organic-rich source rocks.
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Abouzaid, Ahmed, Holger Thern, Mohamed Said, Mohammad ElSaqqa, Mohamed Elbastawesy, and Sherin Ghozlan. "Nuclear Magnetic Resonance Logging While Drilling in Complex Lithology – Solution for a Glauconitic Sandstone Reservoir." In SPE/AAPG Africa Energy and Technology Conference. SPE, 2016. http://dx.doi.org/10.2118/afrc-2579089-ms.

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ABSTRACT The evaluation of logging data in shaly sand reservoirs can be a challenging task, particularly in the presence of accessory minerals such as glauconite. Accessory minerals affect the measurements of conventional logging tools, thus, introducing large uncertainties for estimated petrophysical properties and reservoir characterization. The application of traditional Gamma Ray and Density-Neutron crossover methods can become unreliable even for the simple objective of differentiating reservoir from non-reservoir zones. This was the situation for many years in the glauconite-rich Upper Bahariya formation, Western Desert, Egypt. Formation evaluation was challenging and the results often questionable. Adding Nuclear Magnetic Resonance (NMR) Logging While Drilling (LWD) data in three wells changed the situation radically. The NMR data unambiguously indicate pay zones and simplify the interpretation for accurate porosity and fluid saturation dramatically. Key to success is NMR total porosity being unaffected by the presence of accessory minerals. NMR moveable fluid directly points to the pay zones in the reservoir, while clay-bound and capillary-bound water volumes reflect variations in rock quality and lithology. Although the NMR total porosity is lithology independent, the presence of glauconite affects the NMR T2 distribution by shifting the water T2 response to shorter T2 times. This requires an adjustment of the T2 cutoff position for separating bound water from movable hydrocarbons. A varying T2 cutoff was computed by comparing NMR bound water to resistivity-based water saturation. The calibrated T2 cutoff exhibits an increase with depth indicating a decreasing amount of glauconite with depth throughout the Upper Bahariya formation. Based on these volumetrics, an improved NMR permeability log was calculated, now accurately delineating variations in rock quality throughout the different pay zones. In addition, viscosity was estimated from the oil NMR signal. The estimated values match the expected values very well and illustrate the potential of NMR to indicate viscosity variations. Many of these results are available today already in real-time by transmitting NMR T2 distributions to surface while drilling. Besides the application for formation evaluation, the data can be used to initiate optimized side-tracking and completion decisions directly after finishing the drilling operations.
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Reports on the topic "NMRD"

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Chen, Pictiaw, Boaz Zion, and Michael J. McCarthy. Utilization of NMR Technology for Internal Nondestructive Quality Evaluation of Fruits and Vegetables. United States Department of Agriculture, September 1994. http://dx.doi.org/10.32747/1994.7568778.bard.

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Objective: The objective of this research was to investigate the potential use of NMR for evaluating various internal quality factors of fruits and vegetables, leading to the eventual development of practical techniques that are useful for future development of NMR sensors. Summary: Investigation on NMR imaging, one-dimension NMR projection, and single-pulse free-induction-decay (FID) spectrum led to the development of high-speed NMR techniques for real-time sensing of internal quality of selected fruits. NMR imaging can be used for detecting internal defects and various quality factors such as bruises, dry regions, worm damage, stage of ripeness, tissue breakdown, and the presence of voids, seeds, sprouts, and pits. The one-dimension (1-D) image profile technique, in which the 1-D projection of the NMR signal of a selected slice of the intact fruit is recorded, is suitable for detecting tissue breakdown regions, presence of pits, and other defects in fruits. The oil and sugar content of fruits can be determined from the single-pulse FID spectrum measurement, in which a surface coil is used to acquire the FID spectrum and the ratio of the resonance peaks is used as the quality index. The latter two techniques are suitable for high-speed sorting of fruits. The most important accomplishment is the successful development of high-speed NMR techniques for determining internal quality of fruits while they are moving at speed up to 30 cm/s. This accomplishment is an important step toward the development of NMR techniques for on-line sorting of fruits and vegetables.
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Zilm, K. W. Two dimensional NMR and NMR relaxation studies of coal structure. Office of Scientific and Technical Information (OSTI), May 1992. http://dx.doi.org/10.2172/5062669.

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Zilm, K. W. Two dimensional NMR and NMR relaxation studies of coal structure. Office of Scientific and Technical Information (OSTI), November 1992. http://dx.doi.org/10.2172/6878918.

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Mashingia, Jane, S. Maboko, P. I. Mbwiri, A. Okello, S. I. Ahmada, R. Barayandema, R. Tulba, et al. Joint Medicines Regulatory Procedure in the East African Community: Registration Timelines and Way Forward. Purdue University, November 2021. http://dx.doi.org/10.5703/1288284317429.

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A review of the East African Community (EAC) joint regulatory review process was conducted, registration timelines analyzed and key milestones, challenges and opportunities documented for the period of July 2015 to January 2020. A total of 113 applications were submitted for joint scientific review. Among these, 109 applications were assessed, 57 were recommended for marketing authorisation, 52 applications had queries to applicants and four applications were under review. A total median approval time for all products ranged from 53 to 102 days. The maximum time taken by a regulator to review the dossier was 391 days and the minimum time was 44 days. For applicants, the maximum time to respond to queries was 927 days and the minimum time was nine days. The total median time for granting marketing authorisation by the National Medicines Regulatory Authorities (NMRA) decreased from 174 to 39 working days in 2015 and 2019 respectively. However, not all EAC NMRA has granted marketing authorisation to all 57 products due to non-payment of applicable fees by applicants. Long regulatory approval timelines were contributed by limited capacity for timely scientific review of dossier by some NMRA, lack of online portal to share dossiersand assessment reports, delay in responding to queries by applicants and deficiencies in dossier. The metric tool and register of medical products submitted for joint scientific review had incomplete data. Challenges were identified and actions recommended to ensure regional regulatory system optimization, efficiency, transparency, sustainability and accountability.
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Kenes, Bulent. NMR: A Nordic neo-Nazi organization with aims of establishing totalitarian rule across Scandinavia. European Center for Populism Studies (ECPS), April 2021. http://dx.doi.org/10.55271/op0008.

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Right-wing extremism and national socialism (Nazism) are not a new phenomenon in Sweden. White supremacists or neo-Nazis have a long history in the country. Nordic Resistance Movement (Nordiska motståndsrörelsen, NMR) rests on this century-long history of Swedish Nazi and Neonazi activism. Including racism, antisemitism, anti-immigration, and anti-globalisation stances with violent tendencies, NMR which aims to overthrow the democratic order in the Nordic region and establish a national socialist state, has become the primary force of white power in Sweden and other Nordic countries.
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Swenson, Robert. NMD BM/C3 Implementation,. Fort Belvoir, VA: Defense Technical Information Center, September 1996. http://dx.doi.org/10.21236/ada319963.

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Jones, Patricia. 3706 Update for NMED 9-30-13. Office of Scientific and Technical Information (OSTI), September 2013. http://dx.doi.org/10.2172/1095205.

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Petersen, Ane Kofod Petersen. Effekten af budgetnedskæringer i NMR. Nordic Council of Ministers, June 2016. http://dx.doi.org/10.6027/na2016-909.

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Yamamoto, Yoshihisa. Solid-State NMR Quantum Computer. Fort Belvoir, VA: Defense Technical Information Center, September 2005. http://dx.doi.org/10.21236/ada442582.

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Raftery, M. Daniel. Optical pumping and xenon NMR. Office of Scientific and Technical Information (OSTI), November 1991. http://dx.doi.org/10.2172/10138720.

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