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Journal articles on the topic 'Nobiletm'

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Published: 5 June 2025

Last updated: 1 August 2025

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1

Geeta, Rani, Yadav Lalita, and B. Kalidhar S. "Phytochemical investigation of Citrus sinensis flavedo variety Blood Red." Journal of Indian Chemical Society Vol. 88, Jun 2011 (2011): 887–88. https://doi.org/10.5281/zenodo.5771356.

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Department of Chemistry and Physics, CCS Haryana Agncultural Umversity, Hisar-125 004, Haryana, India <em>E-mail</em> sbkahdhar@gmaii com <em>Manuscript received 01 February 2010, accepted 16 November 2010</em> Phytochemical examination or <em>Citrus simensis</em> flavedo var. Blood Red resulted in the isolation of seven compounds characterized as methyl tritriacontamoate, methyl triacontanoate, pentacosanmc acid, nobiletm, smensetm, 5,4'di hydroxy-7,3'-dimetboxy flavanone 3-<em>O</em>-β-glucoside and glucose.

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2

Holste, Karsten, and Dietlind Huchtker. "Le arene del mutamento elitario nell'Europa dell'800." PASSATO E PRESENTE, no. 77 (May 2009): 111–21. http://dx.doi.org/10.3280/pass2009-077007.

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- Arenas of Élite Change in 19th Century Europe is a group research project. At the core of the investigation are the places of élite-building in the 19th century, and how concrete "compromises" between old and new élites were arrived at. The aim is to get beyond certain normative historiographical paradigms, particularly those related to research on "bourgeoisie", "nobility", and central-eastern Europe.Key words: Central-eastern Europe, 19th century, élites, bourgeoisie, nobility. Parole chiave: Europa centro-orientale, '800, élites, borghesia, nobiltŕ.

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3

Papagna, Elena. "La nobiltÀ nel Mezzogiorno d'Italia durante il Decennio francese." SOCIETÀ E STORIA, no. 123 (June 2009): 31–55. http://dx.doi.org/10.3280/ss2009-123003.

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- In the first part of the essay the author examines the law on nobility enacted in southern Italy under French domination by linking it to measures taken by the Bourbon government in the second half of the Eighteenth Century. Two stages have been identified in Napoleonic legislation: the first deprives the ancient nobility of the Kingdom of its legal privileges maintaining only an honorary distinction; the second establishes a new nobility, intended to confer symbolic and material rewards on those who distinguished themselves in the service of the State and the Dynasty. An advisory board – th

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4

Puchowski, Kazimierz. "Rector Marcin Poczobut on the Concept of Boarding Schools for the Impoverished Nobility in the Era of the Committee of National Education." Senoji Lietuvos literatūra 51 (December 30, 2021): 119–44. https://doi.org/10.51554/sll.21.51.08.

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From the moment the Committee of National Education had taken control of educational matters, the dominant role of the exclusive private colleges (Collegia Nobilium) in the education of the noble elite was reduced. The Commission opened boarding schools for the impoverished nobility, which were extremely important for the process of democratisation of education in the institutions of the Republic of the Two Nations. This type of institution meant that the acquisition of the knowledge necessary for a future profession did not necessitate becoming a student in the service of a magnate. The educa

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5

Prelipcean, Laura. "Dialogic Construction and Interaction in Lodovico Domenichi’s La nobiltà delle donne." Renaissance and Reformation 39, no. 2 (2016): 61–84. http://dx.doi.org/10.33137/rr.v39i2.26854.

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Lodovico Domenichi (1515–64), one of the major polymaths of sixteenth-century Italy, is currently enjoying a marked revival in the critical literature. Although he has been studied in the context of his contemporary printing and publishing activities, the dissemination of works in the vernacular, the promotion of women’s writings, and the religious crisis of that time, little attention has been devoted to him as a writer. In 1549 Domenichi published a dialogue on and for women, La nobiltà delle donne (The nobility of women). This work allowed him to contribute to the advancement of the women’s

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Smutok, Ihor, Yaroslav Lyseyko, and Lesia Smutok. "The documents of the Lviv nouble court (1784-1855) as a source of the genealogy and history of the Halych gentry." Scientific Papers of the Kamianets-Podilskyi National Ivan Ohiienko University. History 33 (October 7, 2021): 64–74. http://dx.doi.org/10.32626/2309-2254.2021-33.64-74.

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The purpose and objectives of the research are to analyze the source studies the potential of the documents of the Lviv Nouble court (Forum Nobilium) through the prism of studying the genealogy and history of the Halych gentry in the late XVIII-XIX centuries. The research methodology is based on the principles of historism, scientificity, verification, as well as on the use of general scientific (analysis, synthesis, generalization) and special-historical (historical-typological, historical-systemic) methods. The scientific novelty consists in the fact that a source review of archival material

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7

Goodwin, James S. "Nobility." Annals of Internal Medicine 134, no. 7 (2001): 621. http://dx.doi.org/10.7326/0003-4819-134-7-200104030-00017.

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8

Harris, Dale. "Lesser Nobility." Opera Quarterly 5, no. 1 (1987): 131–34. http://dx.doi.org/10.1093/oq/5.1.131.

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9

KLIMASEWISKI, MARSHALL N. "NOBILE'S AIRSHIP." Yale Review 87, no. 1 (2010): 111–31. http://dx.doi.org/10.1111/j.1467-9736.1999.tb00100.x.

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10

KOHARA, Kazuma. "Sociology of “Nobility”." Japanese Sociological Review 52, no. 2 (2001): 196–213. http://dx.doi.org/10.4057/jsr.52.196.

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11

Warneke, Sara, and G. W. Bernard. "The Tudor Nobility." Sixteenth Century Journal 24, no. 4 (1993): 1057. http://dx.doi.org/10.2307/2541712.

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12

Kulakova, Irina. "Russia's "Enlightened Nobility"." Russian Studies in History 48, no. 3 (2009): 63–91. http://dx.doi.org/10.2753/rsh1061-1983480304.

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13

Canaff, Roger. "Nobility in objectivity." Journal of Forensic Nursing 5, no. 2 (2009): 89–96. http://dx.doi.org/10.1111/j.1939-3938.2009.01039.x.

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14

Woods, Robert L. "The Tudor Nobility." History: Reviews of New Books 22, no. 4 (1994): 161–62. http://dx.doi.org/10.1080/03612759.1994.9949069.

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15

Miao, Maosheng. "React with nobility." Nature Chemistry 9, no. 5 (2017): 409–10. http://dx.doi.org/10.1038/nchem.2768.

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16

NINAN, MRS ROSAMMA. "NOBILITY OF NURSING." Nursing Journal of India LXXIX, no. 11 (1988): 307. http://dx.doi.org/10.48029/nji.1988.lxxix1105.

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17

Yuan, Fahu, Xinghua Liao, and Tongcun Zhang. "Nobiletin enhances Pirarubicin chemosensitivity of breast cancer cell MDA-MB-231 by regulating PER2." E3S Web of Conferences 233 (2021): 02010. http://dx.doi.org/10.1051/e3sconf/202123302010.

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To explore the potential mechanism of nobiletin in improving the sensitivity of breast cancer MDA-MB-231 cells to Pirarubicin. MDA-MB-231 cells were randomly divided into Control group, Nobiletin group, Pirarubicin group and Nobiletin co-Pirarubicin group. CCK-8 assay was used to detect the inhibitory effect of Nobiletin co-Pirarubicin on the proliferation of MDA-MB-231 cells, and the cell cycle and apoptosis of MDA-MB-231 cells were detected by flow cytometry. The effect of nobiletin combined with Pirarubicin on the migration and repair ability of MDA-MB-231 cells was detected by scratch test

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18

Puchowski, Kazimierz. "European pedigree of the Collegium Nobilium in Ostroh." Острозька давнина 1, no. 6 (2019): 174–86. http://dx.doi.org/10.25264/2707-1650-2019-6-174-186.

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У статті розкривається історія «шляхетської школи» – філіалу Острозького єзуїтського колеґіуму, заснованого в 1640 р. коштом Анни-Алоїзи Ходкевич. Автор акцентує увагу на викладацькому складі та навчальній програмі закладу у XVIII ст., порівнює його із іншими шляхетськими конвіктами тогочасної Речі Посполитої та Європи.

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19

Zhang, Yan, Yaping Yang, Huicong Liang, et al. "Nobiletin, as a Novel PDE4B Inhibitor, Alleviates Asthma Symptoms by Activating the cAMP-PKA-CREB Signaling Pathway." International Journal of Molecular Sciences 25, no. 19 (2024): 10406. http://dx.doi.org/10.3390/ijms251910406.

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Asthma is a chronic airway inflammation that is considered a serious public health concern worldwide. Nobiletin (5,6,7,8,3′,4′-hexamethyl flavonoid), an important compound isolated from several traditional Chinese medicines, especially Citri Reticulatae Pericarpium, is widely used for a number of indications, including cancer, allergic diseases, and chronic inflammation. However, the mechanism by which nobiletin exerts its anti-asthmatic effect remains unclear. In this research, we comprehensively demonstrated the anti-asthmatic effects of nobiletin in an animal model of asthma. It was found t

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20

Cajas, Yulia N., Karina Cañón-Beltrán, Carolina Núñez-Puente, et al. "Nobiletin-induced partial abrogation of deleterious effects of AKT inhibition on preimplantation bovine embryo development in vitro†." Biology of Reproduction 105, no. 6 (2021): 1427–42. http://dx.doi.org/10.1093/biolre/ioab184.

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Abstract During preimplantational embryo development, PI3K/AKT regulates cell proliferation and differentiation and nobiletin modulates this pathway to promote cell survival. Therefore, we aimed to establish whether, when the AKT cascade is inhibited using inhibitors III and IV, nobiletin supplementation to in vitro culture media during the minor (2- to 8-cell stage, MNEGA) or major (8- to 16-cell stage, MJEGA) phases of EGA is able to modulate the development and quality of bovine embryos. In vitro zygotes were cultured during MNEGA or MJEGA phase in SOF + 5% FCS or supplemented with: 15 μM A

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21

Lin, Ching-Yen, Pei-Yi Chen, Hao-Jen Hsu, Wan-Yun Gao, Ming-Jiuan Wu, and Jui-Hung Yen. "The Citrus Flavonoid Nobiletin Downregulates Angiopoietin-like Protein 3 (ANGPTL3) Expression and Exhibits Lipid-Modulating Effects in Hepatic Cells and Adult Zebrafish Models." International Journal of Molecular Sciences 23, no. 20 (2022): 12485. http://dx.doi.org/10.3390/ijms232012485.

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Nobiletin, a dietary citrus flavonoid, exerts biological activities against hyperlipidemia, obesity, and atherosclerotic cardiovascular diseases (ASCVDs). The aim of this study was to explore the lipid-lowering effects of nobiletin and the underlying molecular mechanisms in vitro in hepatic cells and in vivo in zebrafish models. Transcriptome and gene ontology (GO) analyses of differentially expressed genes (DEGs) by gene set enrichment analysis (GSEA) showed that a set of twenty-eight core enrichment DEGs associated with “GO BP regulation of lipid metabolic process” (GO: 0019216) were signifi

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22

Takada, Kimihiko, Mayuko Takano, Aiko Kunii, et al. "Nobiletin represses change in the levels of blood coagulation markers in the LPS-induced rat DIC model." Functional Foods in Health and Disease 10, no. 9 (2020): 397. http://dx.doi.org/10.31989/ffhd.v10i9.732.

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Background: Nobiletin is contained in Shiikuwasa fruit, a popular citrus fruit from Okinawa Prefecture in Japan. Nobiletin reportedly acts as a strong antioxidant, an anti-inflammatory agent, and an anti-cancer agent, and it suppresses the expression of TF which triggers blood coagulation. However, in vivo verification of in vitro reports is necessary. This study used a rat model of LPS-induced microthrombosis based on the in vivo studies as previously reported. Sustained intravenous injection of LPS changed all blood coagulation indicators in the direction of thrombus formation. The aim of th

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23

Morrow, Nadya M., Amy C. Burke, Joshua P. Samsoondar, et al. "The citrus flavonoid nobiletin confers protection from metabolic dysregulation in high-fat-fed mice independent of AMPK." Journal of Lipid Research 61, no. 3 (2020): 387–402. http://dx.doi.org/10.1194/jlr.ra119000542.

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Obesity, dyslipidemia, and insulin resistance, the increasingly common metabolic syndrome, are risk factors for CVD and type 2 diabetes that warrant novel therapeutic interventions. The flavonoid nobiletin displays potent lipid-lowering and insulin-sensitizing properties in mice with metabolic dysfunction. However, the mechanisms by which nobiletin mediates metabolic protection are not clearly established. The central role of AMP-activated protein kinase (AMPK) as an energy sensor suggests that AMPK is a target of nobiletin. We tested the hypothesis that metabolic protection by nobiletin requi

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24

Yuk, Taewon, Younghwa Kim, Jinwoo Yang, Jeehye Sung, Heon Sang Jeong, and Junsoo Lee. "Nobiletin Inhibits Hepatic Lipogenesis via Activation of AMP-Activated Protein Kinase." Evidence-Based Complementary and Alternative Medicine 2018 (2018): 1–8. http://dx.doi.org/10.1155/2018/7420265.

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We aimed to investigate the effects of nobiletin on hepatic lipogenesis in high glucose-induced lipid accumulation in HepG2 cells. Nobiletin, a citrus polymethoxyflavonoid with six methoxy groups, is present abundantly in the peels of citrus fruits. HepG2 cells were incubated in Dulbecco’s modified Eagle’s medium containing high glucose (25 mM) and subsequently treated with nobiletin at different concentrations (5, 25, and 50 μM). Results showed that nobiletin markedly inhibited high glucose-induced hepatic lipid accumulation in HepG2 cells. In addition, it reduced the protein expression of li

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25

Sharikadze, Nino, Natia Jojua, Maia Sepashvili, Elene Zhuravliova, and David G. Mikeladze. "Mitochondrial Target of Nobiletin's Action." Natural Product Communications 11, no. 12 (2016): 1934578X1601101. http://dx.doi.org/10.1177/1934578x1601101215.

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Nobiletin is an O-methylated flavonoid found in citrus peels that have anticancer, antiviral, neuroprotective, anti-inflammatory activities and depending on the cell types exhibits both pro- or anti-apoptotic properties. We have found that nobiletin decreases oxygen consumption by bovine brain isolated mitochondria in the presence of glutamate and malate and increases in the presence of succinate. In parallel, nobiletin increases NADH oxidation, a-ketoglutarate dehydrogenase activities and through matrix substrate-level phosphorylation elevates the a-ketoglutarate-dependent production of ATP.

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26

Ryan, Conn, Yu Tahara, Atsushi Haraguchi, Yuanyuan Lu, and Shigenobu Shibata. "Nobiletin Stimulates Adrenal Hormones and Modulates the Circadian Clock in Mice." Nutrients 16, no. 10 (2024): 1491. http://dx.doi.org/10.3390/nu16101491.

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Polymethoxyflavonoids, such as nobiletin (abundant in Citrus depressa), have been reported to have antioxidant, anti-inflammatory, anticancer, and anti-dementia effects, and are also a circadian clock modulator through retinoic acid receptor-related orphan receptor (ROR) α/γ. However, the optimal timing of nobiletin intake has not yet been determined. Here, we explored the time-dependent treatment effects of nobiletin and a possible novel mechanistic idea for nobiletin-induced circadian clock regulation in mice. In vivo imaging showed that the PER2::LUC rhythm in the peripheral organs was alte

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Butvilaitė, Rasa. "Architektas XVIII amžiaus Lietuvos Didžiosios Kunigaikštystės visuomenėje." Lietuvos Didžioji Kunigaikštystė Luomas. Pašaukimas. Užsiėmimas, T. 5 (January 1, 2021): 254–70. http://dx.doi.org/10.33918/23516968-005012.

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ARCHITECT IN THE SOCIETY OF THE 18TH CENTURY GRAND DUCHY OF LITHUANIA The article deals with the problem of professional field of activity of an architect, the place of his profession in the system of crafts, sciences and arts, architects’ position in the society of the eighteenth century. Before the education reform undertaken by the Education Commission, architecture had not been developed into a separate subject that provided professional training in the schools of the Grand Duchy of Lithuania. The course in architecture was only a part of general education in Vilnius Jesuit Academy, in nob

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Morrow, Nadya M., Natasha A. Trzaskalski, Antonio A. Hanson, et al. "Nobiletin Prevents High-Fat Diet-Induced Dysregulation of Intestinal Lipid Metabolism and Attenuates Postprandial Lipemia." Arteriosclerosis, Thrombosis, and Vascular Biology 42, no. 2 (2022): 127–44. http://dx.doi.org/10.1161/atvbaha.121.316896.

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Objective: Nobiletin is a dietary flavonoid that improves insulin resistance and atherosclerosis in mice with metabolic dysfunction. Dysregulation of intestinal lipoprotein metabolism contributes to atherogenesis. The objective of the study was to determine if nobiletin targets the intestine to improve metabolic dysregulation in both male and female mice. Approach and Results: Triglyceride-rich lipoprotein (TRL) secretion, intracellular triglyceride kinetics, and intestinal morphology were determined in male and female LDL (low-density lipoprotein) receptor knockout ( Ldlr –/– ), and male wild

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29

Klietkutė, Jolanta. "Genealogy of Mongirdai Nobility." Bibliotheca Lituana 6 (December 20, 2019): 121–47. http://dx.doi.org/10.15388/bibllita.2018.vi.8.

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The Author dealswith the forgotten history of the Mongird family of Samogitia. After conductinganalysis of Mongirdai family, genealogical table was compiled. According to statististics, extended family was active in both number of persons and in geographical distribution. Mongird(as) descendantsspread over much of the territory of the Polish–Lithuanian Commonwealth – formally, the Crown of the Kingdom of Poland and the Grand Duchy of Lithuania and, after 1791, the Commonwealth of Poland and Tsar Russia (Russian Empire). Family itself Most members of the extended family bacame of priests, docto

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30

Józsa, Attila. "The Role of Nobility." Acta Universitatis Sapientiae, European and Regional Studies 16, no. 1 (2019): 123–34. http://dx.doi.org/10.2478/auseur-2019-0015.

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31

Martin, Alexander M. "The Alienated Russian Nobility?" Kritika: Explorations in Russian and Eurasian History 21, no. 4 (2020): 861–75. http://dx.doi.org/10.1353/kri.2020.0044.

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32

Hart, Julian Tudor. "Nobility is not enough." Lancet 350, no. 9073 (1997): 299. http://dx.doi.org/10.1016/s0140-6736(97)25030-0.

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33

Solomon, Maynard. "Beethoven: The Nobility Pretense." Musical Quarterly 75, no. 4 (1991): 207–24. http://dx.doi.org/10.1093/mq/75.4.207.

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Rustamli, Asif. "Wise simplicity and nobility." AZERBAIJAN LITERATURE STUDIES, no. 02 (2024): 12. https://doi.org/10.59849/2663-4406.2024.2.12.

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35

Kihara-Negishi, Fumiko, Naoki Ohkura, Yuka Takahashi та ін. "Nobiletin and 3′-Demethyl Nobiletin Activate Brown Adipocytes upon β-Adrenergic Stimulation". Biological and Pharmaceutical Bulletin 45, № 4 (2022): 528–33. http://dx.doi.org/10.1248/bpb.b21-00988.

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36

Hunyadi, Zsolt. "MAIORES, OPTIMATES, NOBILES." East Central Europe 29, no. 1-2 (2002): 135–43. http://dx.doi.org/10.1163/187633002x00109.

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37

Lichacz, Piotr. "Szlachetność jako aspekt dojrzałości moralnej." Przegląd Tomistyczny 30 (May 27, 2025): 139–65. https://doi.org/10.12775/pt.2544-1000.30.06.

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Nobility as an Aspect of Moral Maturity I propose an analysis of the notion of moral nobility and the place of nobility in the dynamism of moral development. I explore some of the etymological, cultural and philosophical roots of the concept, drawing especially on Aquinas’ writings, so as to present nobility as an aspect of moral maturity and spiritual beauty.

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38

Han, Sang Hyup, Jeong Hee Han, Wan Joo Chun, Sang Soo Lee, Hae Sung Kim та Jin Won Lee. "Nobiletin Inhibits Non-Small-Cell Lung Cancer by Inactivating WNT/β-Catenin Signaling through Downregulating miR-15-5p". Evidence-Based Complementary and Alternative Medicine 2021 (30 грудня 2021): 1–9. http://dx.doi.org/10.1155/2021/7782963.

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Background. Nobiletin is a natural compound with anticancer activity; however, the mechanism is not clear. Methods. The inhibitory effect of nobiletin on non-small-cell lung cancer (NSCLC) cells was examined using soft agar, Transwell, and apoptosis analyses. Cancer stemness was measured by sphere assay. Genes and miRNAs regulated by nobiletin were identified by whole-genome sequencing. Protein levels were detected by western blot and immunofluorescence assays. Results. Nobiletin significantly inhibited NSCLC cell colony formation and sphere formation and induced apoptosis. Nobiletin upregulat

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Li, Jing, Zaijun Li, and Fei Zheng. "Nobiletin Inhibits Proliferation, Invasion, Migration and Angiogenesis in Colorectal Cancer Cells." Journal of Biomaterials and Tissue Engineering 9, no. 5 (2019): 662–67. http://dx.doi.org/10.1166/jbt.2019.2022.

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Aim/Background: The nobiletin is a polymethoxyflavonoid isolated from citrus, which is a traditional Chinese herbal medicine. The nobiletin could inhibit the development of human cancer. However, the role of nobiletin in human colorectal cancer (CRC) remains unknown. The present study aimed to explore the nobiletin function in CRC cell proliferation, migration, invasion and angiogenesis as well as the occurrence mechanisms. Methods: The cell counting kit-8 assay (CCK-8 assay) and Brdu (5-brom-2-odeoxyuridine) staining assay were used to determine the effect of nobiletin on cell proliferation.

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Seo, Tae-Beom, Yoon-A. Jeon, Sang Suk Kim, and Young Jae Lee. "In Vitro and In Vivo Effects of Nobiletin on DRG Neurite Elongation and Axon Growth after Sciatic Nerve Injury." International Journal of Environmental Research and Public Health 18, no. 17 (2021): 8988. http://dx.doi.org/10.3390/ijerph18178988.

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Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Thus, the purpose of this study was to investigate whether nobiletin increases DRG neurite elongation and regeneration-related protein expression after SNI. Cytotoxicity of nobiletin was measured in a concentration–dependent manner using the MTT assay. For an in vitro primary cell culture, the sciatic nerve on the middle thigh was crushed by holding twice with forceps.

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41

Hao, Yuan, Cindy S. T. Cheung, Wallace C. Y. Yip, and Wing-hung Ko. "Nobiletin Stimulates Chloride Secretion in Human Bronchial Epithelia via a cAMP/PKA-Dependent Pathway." Cellular Physiology and Biochemistry 37, no. 1 (2015): 306–20. http://dx.doi.org/10.1159/000430355.

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Background/Aims: Nobiletin, a citrus flavonoid isolated from tangerines, alters ion transport functions in intestinal epithelia, and has antagonistic effects on eosinophilic airway inflammation of asthmatic rats. The present study examined the effects of nobiletin on basal short-circuit current (ISC) in a human bronchial epithelial cell line (16HBE14o-), and characterized the signal transduction pathways that allowed nobiletin to regulate electrolyte transport. Methods: The ISC measurement technique was used for transepithelial electrical measurements. Intracellular calcium ([Ca2+]i) and cAMP

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42

Pivoras, Saulius. "The genesis of modern Baltic nations and the nobility in the end of XVIII - first half of XIX c. (A comparative historical analysis)." Lietuvos istorijos studijos 5 (December 28, 1997): 52–77. http://dx.doi.org/10.15388/lis.1997.37291.

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This article applies a comparative method for studying the role of the nobility in the formation of modern Baltic nations in order to elucidate the factors, which determined role differences. Noble attitudes to ethnosocial changes, changes of ethnopolitical self-consciousness of nobility and the position of nobility in the emergence of national cultures are scrutinized. As it follows from the comparison, deconstruction of the feudal social system in Lithuania made the nobility turn their attention to the peasantry and to common interests and common origins, to find out ethnogenetical community

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Kang, Min-Kyung, Dongyeon Kim, and Young-Hee Kang. "Protective Effect of Nobiletin on High Glucose-Induced Blood-Retinal Barrier (BRB) Breakdown." Current Developments in Nutrition 5, Supplement_2 (2021): 25. http://dx.doi.org/10.1093/cdn/nzab033_025.

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Abstract Objectives Diabetic retinopathy (DR) is a complication of diabetes, caused by high blood glucose levels damaging to blood vessels in the retina. It can leading cause of blindness. Nobiletin is a polymethoxyflavone present in citrus fruit and peels, it has anti-cancer and anti-inflammatory effects. This study investigated the protective effects of nobiletin on retinal blood-retinal barrier (BRB) breakdown in high glucose-exposed human retinal endothelial cells and in db/db mouse eyes. Methods Human retinal microvascular endothelial cell (HRMVEC) were incubated in media exposed to 33 mM

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Kang, Min kyung, Dongyeon Kim, and Young-Hee Kang. "Renoprotective Effects of Nobiletin on High Glucose-Induced Loss of Proximal Tubular Microvilli." Current Developments in Nutrition 4, Supplement_2 (2020): 412. http://dx.doi.org/10.1093/cdn/nzaa045_045.

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Abstract Objectives Kidney proximal tubular epithelium has microvillar brush borders, which is critical to renal reabsorption. Hyperglycemia induce change the loss of brush border and cellular polarity, tight junction disruption. Nobiletin is a polymethoxyflavone present in citrus fruit and peels, and has anti-inflammatory effects. This study investigated the renoprotective effects of nobiletin on proximal tubule microvillar ultrastructure and reabsorption under diabetic condition. Methods Human renal proximal tubular epithelial cells (RPTEC) were incubated in a media exposed to 33 mM glucose

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Nishi, Kosuke, Yuki Nakatani, Momoko Ishida, Ayumu Kadota, and Takuya Sugahara. "Anti-Inflammatory Activity of the Combination of Nobiletin and Docosahexaenoic Acid in Lipopolysaccharide-Stimulated RAW 264.7 Cells: A Potential Synergistic Anti-Inflammatory Effect." Nutrients 16, no. 13 (2024): 2080. http://dx.doi.org/10.3390/nu16132080.

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This study aimed to investigate a synergistic anti-inflammatory effect of a citrus flavonoid nobiletin and docosahexaenoic acid (DHA), one of n-3 long-chain polyunsaturated fatty acids, in combination. Simultaneous treatment with nobiletin and DHA synergistically inhibited nitric oxide production (combination index < 0.9) by mouse macrophage-like RAW 264.7 cells stimulated with lipopolysaccharide (LPS) without cytotoxicity. On the other hand, the inhibitory effect of nobiletin and DHA in combination on proinflammatory cytokine production was not synergistic. Neither nobiletin nor DHA affect

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Ren, Xiang, Yuran Ma, Xiao Wang, et al. "Nobiletin Inhibits Cell Growth, Migration and Invasion, and Enhances the Anti-Cancer Effect of Gemcitabine on Pancreatic Cancer Cells." Natural Product Communications 16, no. 4 (2021): 1934578X2110040. http://dx.doi.org/10.1177/1934578x211004062.

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Natural products are very promising adjuvants with a variety of biological activities. Nobiletin, a citrus polymethoxyflavone, has been shown to exert an anticancer effect in various cell lines. In this study, we investigated the effects of nobiletin on cell viability, sphere formation, migration and invasion of pancreatic cancer cells, and the underlying mechanisms. Our results demonstrate that nobiletin significantly inhibited PANC-1 cell migration and invasion, and these effects were associated with downregulation of MMP-2. We also found that nobiletin, in a low concentration, exhibited a s

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Takito, Jiro, Junko Kimura, Koji Kajima, et al. "Nerve growth factor enhances the CRE-dependent transcriptional activity activated by nobiletin in PC12 cells." Canadian Journal of Physiology and Pharmacology 94, no. 7 (2016): 728–33. http://dx.doi.org/10.1139/cjpp-2015-0394.

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Prevention and treatment of Alzheimer disease are urgent problems for elderly people in developed countries. We previously reported that nobiletin, a poly-methoxylated flavone from the citrus peel, improved the symptoms in various types of animal models of memory loss and activated the cAMP responsive element (CRE)-dependent transcription in PC12 cells. Nobiletin activated the cAMP/PKA/MEK/Erk/MAPK signaling pathway without using the TrkA signaling activated by nerve growth factor (NGF). Here, we examined the effect of combination of nobiletin and NGF on the CRE-dependent transcription in PC12

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Terenteva, Ekaterina A. "Social terminology in “Traité de la Noblesse” by Gilles-André La Roque de La Lontière (1678)." Novaya i Novejshaya Istoriya, no. 5 (October 29, 2024): 25–37. http://dx.doi.org/10.31857/s0130386424050039.

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The “Traité de la noblesse” by Gilles-André de La Rocque de La Lontière is an example of the treatises on nobility that were prevalent in early modern Europe. The author, a renowned French genealogist, heraldist, and royal historiographer, presented his work as a comprehensive summary and conclusion on the issues surrounding nobility in French society. Although Larocque’s voluminous treatise has been referenced by researchers of the French nobility, it has not been the subject of in-depth investigation by Russian historians. This paper aims to address this gap in the historical literature by a

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Priani, Sani Ega, and Taufik Muhammad Fakih. "STUDI INTERAKSI MOLEKULAR SENYAWA HESPERIDIN DAN NOBILETIN DARI KULIT BUAH JERUK TERHADAP ENZIM TYROSINASE SECARA IN SILICO." Jurnal Ilmiah Farmasi Farmasyifa 4, no. 1 (2021): 17–24. http://dx.doi.org/10.29313/jiff.v4i1.6788.

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Kulit buah jeruk merupakan salah satu limbah yang belum banyak dimanfaatkan. Kulit buah jeruk diketahui mengandung banyak senyawa berkhasiat diantaranya adalah nobiletin dan hesperidin. Senyawa tersebut termasuk golongan senyawa flavonoid yang diketahui berpotensi menginhibisi enzim tyrosinase, suatu enzim yang mengkatalisis sintesis melanin. Penelitian ini bertujuan untuk menganalis secara in silico, interaksi molekular antara senyawa flavonoid utama dari kulit buah jeruk yakni hesperidin dan nobiletin dengan enzim tirosinase dilihat dari parameter energi ikatan dan jenis ikatan yang terjadi.

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Abe, Tomoki, Tomoyuki Sato, and Kazutoshi Murotomi. "Sudachitin and Nobiletin Stimulate Lipolysis via Activation of the cAMP/PKA/HSL Pathway in 3T3-L1 Adipocytes." Foods 12, no. 10 (2023): 1947. http://dx.doi.org/10.3390/foods12101947.

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Polymethoxyflavones are flavonoids that are abundant in citrus fruit peels and have beneficial effects on human health. Previous studies have demonstrated that the polymethoxyflavones, namely sudachitin and nobiletin, ameliorate obesity and diabetes in humans and rodents. Although nobiletin induces lipolysis in adipocytes, lipolytic pathway activation by sudachitin has not been clarified in adipocytes. In this study, the effect of sudachitin on lipolysis was elucidated in murine 3T3-L1 adipocytes. Glycerol release into the medium and activation of the cyclic AMP (cAMP)/protein kinase A (PKA)/h

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