Academic literature on the topic 'NoGo-N2'

The current study examined the association between effortful control and a well-studied neural index of self-regulation, the N2 event-related potential (ERP) component, in toddlers. Participants included 107 toddlers (44 girls) assessed at 30, 36 and 42 months of age. Participants completed a Go/NoGo task while electroencephalography data were recorded. The study focused on the N2 ERP component. Parent-reported effortful control was examined in association with the NoGo N2 ERP component. Findings suggest a positive association between the NoGo N2 component and the inhibitory control subscale of the wider effortful control dimension, suggesting that the N2 component may index processes associated with temperamental effortful control. This article is part of the theme issue ‘Diverse perspectives on diversity: multi-disciplinary approaches to taxonomies of individual differences’.

Background: Nogo-A, a major myelin-associated inhibitor, can inhibit injured optic nerve regeneration. However, whether Amino-Nogo is the most important functional domain of Nogo-A remains unknown. This study aimed to identify the role of Amino-Nogo following optic nerve injury, and the mechanism of the Amino-Nogo-integrin αv signaling pathway in vivo. Methods: Sprague-Dawley rats with optic nerve crush injury were injected with Nogo-A siRNA (Nogo-A-siRNA), the Nogo-66 functional domain antagonist peptide of Nogo-A (Nep1-40) or a recombinant rat Amino-Nogo-A protein (∆20) into the vitreous cavity to knock down Nogo-A, inhibit Nogo-66 or activate the Amino-Nogo, resparately. Retinal ganglion cell (RGC) density, axon regeneration and the pattern of NPN of visual electrophysiology (flash visual evoked potentials [F-VEP]) at different times post-injury were investigated. Results: Our study revealed a lower RGC survival rate; shorter axonal outgrowth; longer N1, P1 and N2 waves latencies; and lower N1-P1 and P1-N2 amplitudes in the Δ20 group, and Δ20 treatment significantly attenuated integrin αv expression and phosphorylated focal adhesion kinase (p-FAK) levels. In the Nep1-40 and Nogo-A siRNA groups, there were higher RGC survival rates, longer axonal outgrowth, shorter N1 and P1 wave latencies, and higher N1-P1 and P1-N2amplitudes. Nogo-A siRNA treatment significantly increased integrin αv expression and p-FAK levels. Nepl-40 treatment did not alter integrin αv expression. In addition, there was no significant change in integrin α5 in any group. Conclusion: These results suggest that the integrin signaling pathway is regulated by Amino-Nogo, which inhibits optic nerve regeneration and functional recovery, and that the integrin subunit involved might be integrin αv but not integrin α5.

Abstract In Go/Nogo tasks, the ERP after Nogo stimuli generally reveals a negativity (Nogo-)N2 and a subsequent positivity (Nogo-)P3 over fronto-central scalp regions. These components are probably related to different subprocesses serving response inhibition, namely, modality-specific and general inhibition, respectively. In the present study we investigate whether aging or prolonged work (“time-on-task”) have an effect on N2 and P3. Twelve young and 12 elderly subjects performed simple Go/Nogo tasks to visual or auditory letter stimuli. Reaction times were longer after visual than after auditory stimuli, and longer in the elderly than in the young. The ERP results reveal a slight impairment of modality-specific inhibition (N2) in the elderly after visual, but not after auditory, stimuli. General inhibition (P3) was delayed in the elderly for both modalities, as was Go-P3 and RT. Hence, it appears that the response slowing of the elderly is the result of a slowing of the decision process whether to respond or to inhibit. Moreover, age appears to affect both aspects of inhibition in a different manner. No effects of time-on-task were found, which suggests that the inhibitory processes are fairly robust against mental fatigue.

Abstract. Aftereffects of noise-induced sleep disturbance on executive functions were investigated with motivational traits as mediating variables. Thirty-two healthy young subjects performed a visual Go/Nogo task with simultaneous EEG recording after a quiet night and after 3 nights with railway noise at different noise levels. As motivational traits, the “hope of success” (HS) and “fear of failure” (FF) were assessed. Subjective sleep rating worsened with increased noise level, but, noise-induced sleep disturbances did not affect performance immediately following sleep. However, in the event-related potential (ERP) an attenuation of the N2 and P3 amplitude as well as an increase in N2 latency in Noise conditions were found. Only subjects who scored low in HS showed a reduction of the N2 after Noise, while subjects who scored high in HS did not. The N2 and P3 were larger in high HS than in low HS subjects in Nogo trials only. Similarly, low FF subjects had larger N2 and P3 than high FF subjects in Nogo trials only. The results suggest that achievement motivation modulates executive control and stimulus-response mapping processes as well as their resistance against aftereffects of noise-induced sleep disturbance.

The ERP components and variations of spatial complexity or functional connectivity are two distinct dimensions of neurophysiological events in the visual Go/Nogo task. Extensive studies have been conducted on these two distinct dimensions; however, no study has investigated whether these two neurophysiological events are linked to each other in the visual Go/Nogo task. The relationship between spatial complexity of electroencephalographic (EEG) data, quantified by the measure omega complexity, and event-related potential (ERP) components in a visual Go/Nogo task was studied. We found that with the increase of spatial complexity level, the latencies of N1 and N2 component were shortened and the amplitudes of N1, N2, and P3 components were decreased. The anterior Go/Nogo N2 effect and the Go/Nogo P3 effect were also found to be decreased with the increase of EEG spatial complexity. In addition, the reaction times in high spatial complexity trials were significantly shorter than those of medium and low spatial complexity trials when the time interval used to estimate the EEG spatial complexity was extended to 0∼1,000 ms after stimulus onset. These results suggest that high spatial complexity may be associated with faster cognitive processing and smaller postsynaptic potentials that occur simultaneously in large numbers of cortical pyramidal cells of certain brain regions. The EEG spatial complexity is closely related with demands of certain cognitive processes and the neural processing efficiency of human brain. NEW & NOTEWORTHY The reaction times, the latencies/amplitudes of event-related potential (ERP) components, the Go/Nogo N2 effect, and the Go/Nogo P3 effect are linked to the electroencephalographic (EEG) spatial complexity level. The EEG spatial complexity is closely related to demands of certain cognitive processes and could reflect the neural processing efficiency of human brain. Obtaining the single-trial ERP features through single-trial spatial complexity may be a more efficient approach than traditional methods.

Abstract. The aim of the present study was to investigate behavioral and electrophysiological indices of developing response activation and inhibition processes in child, young-adult, and adult groups. Sixty subjects, with 20 in each of the child (mean age 10.8 years), young-adult (mean age 20.7 years), and older adult (mean age 36.4 years) groups, performed an auditory Go/NoGo task while task performance variables and EEG were recorded. ERPs were derived to Go (response activation) and NoGo (response inhibition) stimuli, with the amplitude and latency of the N1, P2, N2, and P3 ERP components analyzed as a function of age. Results indicate improved task performance, and a reduction in the latency of each component and the amplitude of the N2 and P3 components, with increasing age. Analyses of Go versus NoGo effects indicated differential utilization of inhibition-related processing stages in children compared to adults, with some minor differences between the two adult groups. Go/NoGo effects were evident during early stages of processing, such as those indexed by the N1 and N2 components in children, but only in later stages, as indexed by P3, in adult subjects. This study provides much-needed data on the normative development of response activation and inhibition, as operationalized by the auditory Go/NoGo task, in children and two groups of younger/older adult subjects.

Objective Attention-deficit and poor impulse control have frequently been observed in major depressive disorder (MDD) and attention-deficit and hyperactivity disorder (ADHD). Altered event-related potential (ERP) performance, such as GoNogo tasks, has been regarded as a neurocognitive process associated with attention and behavioral inhibition. The aim of this study was to investigate the association between Nogo ERP and adult ADHD in MDD.Methods A total of 64 participants with MDD (32 comorbid with ADHD) and 32 healthy controls aged 19–45 years were recruited; they performed GoNogo paradigms during electroencephalogram measurement. Beck Depression Inventory (BDI), State-Trait Anxiety Inventory (STAI), and the Adult ADHD Self-Report Scale (ASRS) were evaluated. Clinical measures and GoNogo ERP were compared between three groups: depression with ADHD, depression without ADHD, and healthy controls.Results MDD subjects with ADHD showed significantly decreased Nogo P3 amplitude at frontal electrode, compared with those without ADHD and healthy controls. MDD subjects with ADHD showed significantly longer Nogo N2 latency at frontal and frontocentral electrodes, compared with those without ADHD and healthy controls. In MDD subjects with ADHD, the Nogo P3 amplitude at the frontal electrode was negatively correlated with the ASRS score and inattention. The Nogo N2 latency at the frontal electrode was positively correlated with false alarm rate.Conclusion The decreased Nogo P3 amplitude in the frontal area might be a potential biological marker for inattention in depressed patients with ADHD.

AbstractGiven the current literature debate on whether or not Problematic Social Network Sites Use (PSNSU) can be considered a behavioral addiction, the present study was designed to test whether, similarly to addictive behaviors, PSNSU is characterized by a deficit in inhibitory control in emotional and addiction-related contexts. Twenty-two problematic Facebook users and 23 nonproblematic users were recruited based on their score on the Problematic Facebook Use Scale. The event-related potentials were recorded during an emotional Go/Nogo Task, including Facebook-related, unpleasant, pleasant, and neutral pictures. The amplitudes of the Nogo-N2 and the Nogo-P3 were computed as measures of the detection of response conflict and response inhibition, respectively. Reaction times and accuracy also were measured. The results showed that problematic users were less accurate on both Go and Nogo trials than nonproblematic users, irrespective of picture content. For problematic users only, the Nogo-P3 amplitude was lower to Facebook-related, pleasant, and neutral than to unpleasant stimuli, suggesting less efficient inhibition with natural and Facebook-related rewards. Of note, all participants were slower to respond to Facebook-related and pleasant Go trials compared with unpleasant and neutral pictures. Consistently, the Nogo-N2 amplitude was larger to Facebook-related than all other picture contents in both groups. Overall, the findings suggest that PSNSU is associated with reduced inhibitory control. These results should be considered in the debate about the neural correlates of PSNSU, suggesting more similarities than differences between PSNSU and addictive behaviors.

La jouissance est un des champs dont la psychanalyse fait usage pour rendre compte de ce qui pourrait expliquer le boitement structurel de la condition humaine, son paradoxe fondamental. Partant d'une épistémologie transcendantale, nous envisageons que, bien que le corps et la psyché ne revêtent pas les mêmes réalités, ils ont certains points d'accroche dont fait partie la jouissance et, bien que le corps ne détermine pas le psychisme, il le contraint. Il est alors proposé ici une hypothèse neuropsychanalytique de la jouissance, l'articulant autour du corps et de l'histoire. La jouissance serait la marque de ce qui a fait événement pour le sujet. Cette description permet de relier ce concept à la neurophysiologie des circuits dopaminergiques qui marquent physiologiquement tant la dimension pulsionnelle, que la dimension événementielle et donc historique.À partir de cette conceptualisation, un paradigme expérimental a été constitué afin d'investiguer cette possibilité d'une accroche entre le psychique et le biologique chez des sujets dépendants, lorsqu'ils sont confrontés à leur objet d'addiction. Concrètement, nous 'osons' l'hypothèse que plus un sujet manifeste d'indices repérables d'une mobilisation pulsionnelle dans son discours libre amorcé par l’objet addictif (dans ce cas-ci, la cigarette pour des fumeurs), plus il aura le geste rapide et sûr pour l’attraper ou des difficultés à inhiber son appétence vers cet objet. Ceci est investigué à travers un outil constitué à partir de la théorie psychanalytique d’une part, et à travers deux tâches de type Go-NoGo (évaluées par des mesures comportementales –temps de réaction et erreurs- et électrophysiologiques -la N2 et la P3, deux marqueurs considérés comme reflétant la signature des processus attentionnels et des biais d’inhibition-, d’autre part. La particularité du paradigme, outre cet usage d’outils issus de champs distincts, réside dans le fait que, à aucun moment, ce n’est le sens du discours des sujets, qui est investigué. L’outil psychanalytique évalue effectivement la façon dont les sujets s’expriment, et ce sont des juges naïfs (à l’égard de l’étude et de la psychanalyse) qui évaluent leur discours. Nos résultats mettent en évidence que les personnes dépendantes manifestent une tendance à l’impulsivité de façon générale. Mais, lorsque leur objet d’addiction est en place de support attentionnel, les sujets démontrent une augmentation significative de leurs performances et de l’amplitude de la P3, signe d’un investissement attentionnel. Les résultats des associations libres révèlent que la forme du discours des fumeurs est évaluée comme plus transgressive (comparativement aux non-fumeurs). Enfin, on retrouve une corrélation entre les indices psychiques (la transgression) et neurophysiologiques (la latence de la NoGo-N2). En conclusion, il semble que l’addiction dépasse la simple réalité pharmacologique de l’effet du toxique puisqu’il est repéré ici que l’effet de stimulant cognitif (manifeste par l’amélioration des performances) est induit par la simple représentation de la cigarette et non par la consommation de celle-ci. Ensuite, au regard de notre proposition épistémologique, nous semblons avoir réussi, sur base d’une lecture rapprochée des séminaires de Lacan, à construire un outil qui distingue de façon cohérente, consistante et valide une dimension pulsionnelle d’une dimension affective (valencée) dans ce qui peut s’entendre. Grâce à cet outil, nous avons trouvé des corrélations entre certains de ces marqueurs psychiques et certains paramètres physiologiques - les paramètres corrélant étant précisément des plus probants et la corrélation s’avérant être dans le sens prédit par notre construction hypothétique. Sur ce 'succès’, nous osons une conclusion épistémologique plus large qui propose que si l’univers du représentationnel, c'est-à-dire, du mental, est bien accroché au niveau de repères physiologiques, ceci n’est démontrable sur un plan mental que si l’on se borne à la forme des contenus mentaux – et, qui plus est, et de façon spéculative, en évitant toute hérméneutique au niveau des contenus mentaux.
Doctorat en Sciences psychologiques et de l'éducation
info:eu-repo/semantics/nonPublished

abstract: In most of the work using event-related potentials (ERPs), researchers presume the function of specific components based on the careful manipulation of experimental factors, but rarely report direct evidence supporting a relationship between the neural signal and other outcomes. Perhaps most troubling is the lack of evidence that ERPs correlate with related behavioral outcomes which should result, at least in part, from the neural processes that ERPs capture. One such example is the NoGo-N2 component, an ERP component elicited in Go/NoGo paradigms. There are two primary theories regarding the functional significance of this component in this context: that the signal represents response inhibition and that the component reflects conflict. In this paper, a trial-level method of analysis for the relationship between ERP component potentials and downstream behavioral outcomes (in this case, response accuracy) using a multi-level modeling framework is proposed to provide discriminatory evidence for one of these theories. Following a description of the research on the NoGo-N2, preliminary data supporting the conflict monitoring theory are presented, noting important limitations. Next, an EEG simulation study is presented in which NoGo-N2 data are generated with a known relationship to fabricated reaction time data, showing that, with added levels of complexity and noise within the data, the MLM approach is consistently successful at extracting the known relationships that occur in real NoGo-N2 data. Next, using independent components analysis (ICA) to extract spatiotemporal components that best represent the signal of interest, a well-powered analysis of the relationship between the NoGo-N2 and response accuracy is used to provide strong discriminatory evidence for the conflict monitoring theory of the NoGo-N2. Finally, implications for the NoGo-N2, as well as all ERP components, are discussed with a focus on how this approach can and should be used. the paper concludes with potential expansions of this approach to areas beyond identifying the function of ERP components.
Dissertation/Thesis
Doctoral Dissertation Psychology 2019

Individual differences in dispositional anxiety and risk for anxiety disorders are heritable. Because robust direct associations between single gene variants and complex anxiety-related phenotypes remain sparse, it is important to identify brain “endophenotypes” that mediate the relationship between genotypes and dispositional anxiety. Due to its high temporal resolution, electroencephalography (EEG) is an ideal non-invasive tool to study individual differences in basic fear and anxiety-related neural processes, which often occur within few hundred milliseconds after threat signals appear. In this chapter, putative anxiety-related EEG markers are presented including the C1, P100, N1, N170, NoGo-N2, P300, Late Positive Potential, Feedback-Related Negativity, Error-Related Negativity, frontal midline theta, and N300H brain–heart-coupling components. For each marker, heritability estimates and/or tentative associations with single gene variants are presented and discussed. While individual differences in anxiety-related EEG activity seem genetically influenced, more replication studies are needed to confirm specific links between gene variants and anxiety-related EEG markers.