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Journal articles on the topic 'Non-canonical Function'

Author: Grafiati

Published: 4 June 2021

Last updated: 2 February 2022

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1

Akbarieh, Amin Rezaei, Hossein Motavalli, and Elham Nouri. "Non-canonical Chameleon cosmology." International Journal of Modern Physics D 30, no. 08 (2021): 2150059. http://dx.doi.org/10.1142/s0218271821500590.

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One of the most important issues in modern cosmology is understanding the origin of the accelerated expansion of the universe, known as “dark energy”. The scalar–tensor model is one of the most interesting candidates for describing dark energy. In this paper, we investigate the non-canonical scalar model, which is written in the framework of Chameleon models. In this model, the scalar field is coupled to a mass density [Formula: see text] under an arbitrary [Formula: see text] coupling function. We study the cosmological aspect of this model according to its Chameleon state and we conclude tha

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Peluso, John J., and James K. Pru. "Non-canonical progesterone signaling in granulosa cell function." REPRODUCTION 147, no. 5 (2014): R169—R178. http://dx.doi.org/10.1530/rep-13-0582.

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It has been known for over 3 decades that progesterone (P4) suppresses follicle growth. It has been assumed that P4 acts directly on granulosa cells of developing follicles to slow their development, as P4 inhibits both mitosis and apoptosis of cultured granulosa cells. However, granulosa cells of developing follicles of mice, rats, monkeys, and humans do not express the A or B isoform of the classic nuclear receptor for P4 (PGR). By contrast, these granulosa cells express other P4 binding proteins, one of which is referred to as PGR membrane component 1 (PGRMC1). PGRMC1 specifically binds P4

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3

Kushiro, Tetsuo. "Non-canonical function of tRNA synthetases from plants." JSM Mycotoxins 68, no. 1 (2018): 55–57. http://dx.doi.org/10.2520/myco.68-1-9.

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Swanson, Carter J., Michael Ritt, William Wang та ін. "Non-Canonical Modular Domain Interactions Dictate PKCα Function". Biophysical Journal 106, № 2 (2014): 467a. http://dx.doi.org/10.1016/j.bpj.2013.11.2643.

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Cheng, Jing, Peter C. Lucas, and Linda M. McAllister-Lucas. "Canonical and Non-Canonical Roles of GRK2 in Lymphocytes." Cells 10, no. 2 (2021): 307. http://dx.doi.org/10.3390/cells10020307.

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G protein-coupled receptor kinase 2 (GRK2) is emerging as a key integrative signaling node in a variety of biological processes ranging from cell growth and proliferation to migration and chemotaxis. As such, GRK2 is now implicated as playing a role in the molecular pathogenesis of a broad group of diseases including heart failure, cancer, depression, neurodegenerative disease, and others. In addition to its long-known canonical role in the phosphorylation and desensitization of G protein-coupled receptors (GPCRs), recent studies have shown that GRK2 also modulates a diverse array of other mol

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Kurz, S., K. Steiger, U. Protzer, P. Knolle, and D. Wohlleber. "Hepatitis B virus escapes non-canonical CTL effector function." Zeitschrift für Gastroenterologie 56, no. 01 (2018): E2—E89. http://dx.doi.org/10.1055/s-0037-1612844.

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7

Sandra, K., K. Steiger, U. Protzer, P. A. Knolle, and D. Wohlleber. "Hepatitis B virus escapes non-canonical CTL effector function." Journal of Hepatology 68 (April 2018): S774—S775. http://dx.doi.org/10.1016/s0168-8278(18)31816-6.

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8

Vasanthakumar, Ajithkumar, Dakang Xu, Aaron TL Lun, et al. "A non‐canonical function of Ezh2 preserves immune homeostasis." EMBO reports 18, no. 4 (2017): 619–31. http://dx.doi.org/10.15252/embr.201643237.

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9

Zhang, Yi. "Non-canonical passives in Chinese." Chinese Language and Discourse 11, no. 1 (2020): 84–106. http://dx.doi.org/10.1075/cld.19001.zha.

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Abstract This paper examines a non-canonical passive construction in Chinese. In this construction, the passive marker bei can proceed a constituent including intransitive verbs, adjectives and nouns, in such expressions as bei zisha/‘commit suicide,’ bei xingfu/‘happy’ or bei gaotie/‘high speed train.’ Following Mental Space Theory (Fauconnier 1994, 1997), this paper argues that the construction serves as a space builder, which prompts conceptualizers to build a counterfactual space to hold the event conveyed by the constituent but deny the event or its associated assumption in the base space

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Termathe, Martin, and Sebastian A. Leidel. "Urm1: A Non-Canonical UBL." Biomolecules 11, no. 2 (2021): 139. http://dx.doi.org/10.3390/biom11020139.

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Urm1 (ubiquitin related modifier 1) is a molecular fossil in the class of ubiquitin-like proteins (UBLs). It encompasses characteristics of classical UBLs, such as ubiquitin or SUMO (small ubiquitin-related modifier), but also of bacterial sulfur-carrier proteins (SCP). Since its main function is to modify tRNA, Urm1 acts in a non-canonical manner. Uba4, the activating enzyme of Urm1, contains two domains: a classical E1-like domain (AD), which activates Urm1, and a rhodanese homology domain (RHD). This sulfurtransferase domain catalyzes the formation of a C-terminal thiocarboxylate on Urm1. T

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Ortiz-Rodríguez, José Manuel, Francisco Eduardo Martín-Cano, Gemma Gaitskell-Phillips, et al. "The SLC7A11: sperm mitochondrial function and non-canonical glutamate metabolism." Reproduction 160, no. 6 (2020): 803–18. http://dx.doi.org/10.1530/rep-20-0181.

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Spermatozoa are redox-regulated cells, and stallion spermatozoa, in particular, present an intense mitochondrial activity in which large amounts of reactive oxygen species (ROS) are produced. To maintain the redox potential under physiological conditions, sophisticated mechanisms ought to be present, particularly in the mitochondria. In the present study, we investigated the role of the SLC7A11 antiporter. This antiporter exchanges intracellular glutamate for extracellular cystine. In the spermatozoa, cystine is reduced to cysteine and used for GSH synthesis. The importance of the antiporter f

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12

Oh, Kwang-Im, Jinwoo Kim, Chin-Ju Park, and Joon-Hwa Lee. "Dynamics Studies of DNA with Non-canonical Structure Using NMR Spectroscopy." International Journal of Molecular Sciences 21, no. 8 (2020): 2673. http://dx.doi.org/10.3390/ijms21082673.

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The non-canonical structures of nucleic acids are essential for their diverse functions during various biological processes. These non-canonical structures can undergo conformational exchange among multiple structural states. Data on their dynamics can illustrate conformational transitions that play important roles in folding, stability, and biological function. Here, we discuss several examples of the non-canonical structures of DNA focusing on their dynamic characterization by NMR spectroscopy: (1) G-quadruplex structures and their complexes with target proteins; (2) i-motif structures and t

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13

Parveen, Nazia, Amen Shamim, Seunghee Cho, and Kyeong Kyu Kim. "Computational Approaches to Predict the Non-canonical DNAs." Current Bioinformatics 14, no. 6 (2019): 470–79. http://dx.doi.org/10.2174/1574893614666190126143438.

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Background: Although most nucleotides in the genome form canonical double-stranded B-DNA, many repeated sequences transiently present as non-canonical conformations (non-B DNA) such as triplexes, quadruplexes, Z-DNA, cruciforms, and slipped/hairpins. Those noncanonical DNAs (ncDNAs) are not only associated with many genetic events such as replication, transcription, and recombination, but are also related to the genetic instability that results in the predisposition to disease. Due to the crucial roles of ncDNAs in cellular and genetic functions, various computational methods have been impleme

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Jin, Jing, Magali Humbert, and Mario P. Tschan. "Non-Canonical Autophagy during APL Therapy." Blood 128, no. 22 (2016): 1621. http://dx.doi.org/10.1182/blood.v128.22.1621.1621.

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Abstract Autophagy is an intracellular degradation system that ensures a dynamic recycling of cytoplasmic contents. Autophagy is required for self-renewal and cell survival under stress caused by a variety of stimuli including starvation and chemotherapy. There is accumulating evidence for additional functions of autophagy during myeloid development and hematopoietic stem cell maintenance. In this study, we used primary acute myeloid leukemia (AML) samples and human APL/AML cell lines to investigate the autophagy pathway active in all-trans retinoic acid (ATRA) mediated neutrophil differentiat

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Chen, Shouwen, Peng Jin, Hao Chen, et al. "Dual function of a turbot inflammatory caspase in mediating both canonical and non-canonical inflammasome activation." Developmental & Comparative Immunology 121 (August 2021): 104078. http://dx.doi.org/10.1016/j.dci.2021.104078.

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Karp, Christopher L., and Peter J. Murray. "Non-canonical alternatives: What a macrophage is 4." Journal of Experimental Medicine 209, no. 3 (2012): 427–31. http://dx.doi.org/10.1084/jem.20120295.

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Macrophages play pleiotropic, niche-specific roles in all tissues and organs. As immune sentinels, tissue macrophages regulate immune activation and inflammation; in turn, their function is modulated by inflammatory mediators deriving from such activation. Recent papers have established unanticipated roles for interleukin 4 and the alternative activation of tissue macrophages in the organismal response to diverse environmental stressors.

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Deiser, Oliver, та Dieter Donder. "Canonical functions, non-regular ultrafilters and Ulam's problem on ω1". Journal of Symbolic Logic 68, № 3 (2003): 713–39. http://dx.doi.org/10.2178/jsl/1058448434.

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AbstractOur main results are:Theorem 1. Con(ZFC + “every function f: ω1 → ω1 is dominated by a canonical function”) implies Con(ZFC + “there exists an inaccessible limit of measurable cardinals”). [In fact equiconsistency holds.]Theorem 3. Con(ZFC + “there exists a non-regular uniform ultrafilter on ω1”) implies Con(ZFC + “there exists an inaccessible stationary limit of measurable cardinals”).Theorem 5. Con (ZFC + “there exists an ω1-sequence of ω1-complete uniform filters on ω1 s.t. every A ⊆ ω1 is measurable w.r.t. a filter in (Ulam property)”) implies Con(ZFC + “there exists an inaccessibl

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18

Bagby, Grover. "Recent advances in understanding hematopoiesis in Fanconi Anemia." F1000Research 7 (January 24, 2018): 105. http://dx.doi.org/10.12688/f1000research.13213.1.

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Fanconi anemia is an inherited disease characterized by genomic instability, hypersensitivity to DNA cross-linking agents, bone marrow failure, short stature, skeletal abnormalities, and a high relative risk of myeloid leukemia and epithelial malignancies. The 21 Fanconi anemia genes encode proteins involved in multiple nuclear biochemical pathways that effect DNA interstrand crosslink repair. In the past, bone marrow failure was attributed solely to the failure of stem cells to repair DNA. Recently, non-canonical functions of many of the Fanconi anemia proteins have been described, including

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19

Zhai, Lijie, April Bell, Jun Qian, Erik Ladomersky, Kristen Lauing, and Derek Wainwright. "IMMU-22. TARGETING NON-CANONICAL FUNCTION OF IDO1 IN GLIOBLASTOMA IMMUNOTHERAPY." Neuro-Oncology 21, Supplement_6 (2019): vi123. http://dx.doi.org/10.1093/neuonc/noz175.515.

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Abstract Recent failure of immune checkpoint blockade, anti-PD-1 therapy in patients suffering recurrent glioblastoma (GBM) indicates that development of novel immunosuppressive mediator-targeted therapeutic strategy is critical for more effective immunotherapies against GBM. Indoleamine 2, 3-dioxygenase 1 (IDO1) has been shown to mediate tumor-induced immunosuppression through its tryptophan catabolic activity. Surprisingly, pharmacological IDO1 enzyme inhibitors have not demonstrated any survival benefit in cancer patients either mono-therapeutically or in combination with other therapies. P

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20

Germe, Thomas, Kyle Miller, and Julia Promisel Cooper. "A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres." EMBO Journal 28, no. 18 (2009): 2803–11. http://dx.doi.org/10.1038/emboj.2009.223.

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21

Lindenboim, Liora, Elisa Ferrando-May, Christoph Borner, and Reuven Stein. "Non-canonical function of Bax in stress-induced nuclear protein redistribution." Cellular and Molecular Life Sciences 70, no. 16 (2013): 3013–27. http://dx.doi.org/10.1007/s00018-013-1306-4.

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22

Misra, Sandip, Ginia Ghosh, Sougata Ghosh Chowdhury, and Parimal Karmakar. "Non-canonical function of nuclear PTEN and its implication on tumorigenesis." DNA Repair 107 (November 2021): 103197. http://dx.doi.org/10.1016/j.dnarep.2021.103197.

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23

Tateishi-Karimata, Hisae, and Naoki Sugimoto. "Roles of non-canonical structures of nucleic acids in cancer and neurodegenerative diseases." Nucleic Acids Research 49, no. 14 (2021): 7839–55. http://dx.doi.org/10.1093/nar/gkab580.

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Abstract Cancer and neurodegenerative diseases are caused by genetic and environmental factors. Expression of tumour suppressor genes is suppressed by mutations or epigenetic silencing, whereas for neurodegenerative disease-related genes, nucleic acid-based effects may be presented through loss of protein function due to erroneous protein sequences or gain of toxic function from extended repeat transcripts or toxic peptide production. These diseases are triggered by damaged genes and proteins due to lifestyle and exposure to radiation. Recent studies have indicated that transient, non-canonica

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24

Ferdosi, Shayesteh, Brett Taylor, Saumya Bollam, et al. "CBMT-23. NON-CANONICAL FUNCTIONS OF TERT IN GLIOBLASTOMA." Neuro-Oncology 21, Supplement_6 (2019): vi38. http://dx.doi.org/10.1093/neuonc/noz175.145.

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Abstract Telomerase is an enzyme with a catalytic subunit, telomerase reverse transcriptase (TERT), that is in charge of telomere elongation in the nucleus. Promotor region of TERT is commonly mutated across cancers, especially in glioblastoma (GBM) with over 80% frequency. In the absence of any effective molecular targeting therapy for GBM, elucidating oncogenic signaling of TERT could open new avenues in GBM treatment. Canonically, mutations of TERT, which result in TERT upregulation, maintain telomere length in the nucleus and promote indefinite proliferation of cancer cells. However, a non

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25

Polacheck, William J., Matthew L. Kutys, Jinling Yang, et al. "A non-canonical Notch complex regulates adherens junctions and vascular barrier function." Nature 552, no. 7684 (2017): 258–62. http://dx.doi.org/10.1038/nature24998.

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26

Murray, Jill I., Rodger B. Voelker, Kristy L. Henscheid, M. BRYAN Warf, and J. ANDREW Berglund. "Identification of motifs that function in the splicing of non-canonical introns." Genome Biology 9, no. 6 (2008): R97. http://dx.doi.org/10.1186/gb-2008-9-6-r97.

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27

Uysal-Onganer, P., and R. M. Kypta. "Wnt11 in 2011 - the regulation and function of a non-canonical Wnt." Acta Physiologica 204, no. 1 (2011): 52–64. http://dx.doi.org/10.1111/j.1748-1716.2011.02297.x.

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28

D’Ignazio, Laura, Michael Batie та Sonia Rocha. "TNFSF14/LIGHT, a Non-Canonical NF-κB Stimulus, Induces the HIF Pathway". Cells 7, № 8 (2018): 102. http://dx.doi.org/10.3390/cells7080102.

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Non-canonical NF-κB signalling plays important roles in the development and function of the immune system but it also is deregulated in a number of inflammatory diseases. Although, NF-κB and HIF crosstalk has been documented, this has only been described following canonical NF-κB stimulation, involving RelA/p50 and the HIF-1 dimer. Here, we report that the non-canonical inducer TNFSF14/LIGHT leads to HIF induction and activation in cancer cells. We demonstrate that only HIF-2α is induced at the transcriptional level following non-canonical NF-κB activation, via a mechanism that is dependent on

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Kumar, Vaishali, and Shuvadeep Maity. "ER Stress-Sensor Proteins and ER-Mitochondrial Crosstalk—Signaling Beyond (ER) Stress Response." Biomolecules 11, no. 2 (2021): 173. http://dx.doi.org/10.3390/biom11020173.

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Recent studies undoubtedly show the importance of inter organellar connections to maintain cellular homeostasis. In normal physiological conditions or in the presence of cellular and environmental stress, each organelle responds alone or in coordination to maintain cellular function. The Endoplasmic reticulum (ER) and mitochondria are two important organelles with very specialized structural and functional properties. These two organelles are physically connected through very specialized proteins in the region called the mitochondria-associated ER membrane (MAM). The molecular foundation of th

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Nelson, David E., Suzanne J. Randle, and Heike Laman. "Beyond ubiquitination: the atypical functions of Fbxo7 and other F-box proteins." Open Biology 3, no. 10 (2013): 130131. http://dx.doi.org/10.1098/rsob.130131.

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F-box proteins (FBPs) are substrate-recruiting subunits of Skp1-cullin1-FBP (SCF)-type E3 ubiquitin ligases. To date, 69 FBPs have been identified in humans, but ubiquitinated substrates have only been identified for a few, with the majority of FBPs remaining ‘orphans’. In recent years, a growing body of work has identified non-canonical, SCF-independent roles for about 12% of the human FBPs. These atypical FBPs affect processes as diverse as transcription, cell cycle regulation, mitochondrial dynamics and intracellular trafficking. Here, we provide a general review of FBPs, with a particular

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Chakafana, Graham, and Addmore Shonhai. "The Role of Non-Canonical Hsp70s (Hsp110/Grp170) in Cancer." Cells 10, no. 2 (2021): 254. http://dx.doi.org/10.3390/cells10020254.

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Although cancers account for over 16% of all global deaths annually, at present, no reliable therapies exist for most types of the disease. As protein folding facilitators, heat shock proteins (Hsps) play an important role in cancer development. Not surprisingly, Hsps are among leading anticancer drug targets. Generally, Hsp70s are divided into two main subtypes: canonical Hsp70 (Escherichia coli Hsp70/DnaK homologues) and the non-canonical (Hsp110 and Grp170) members. These two main Hsp70 groups are delineated from each other by distinct structural and functional specifications. Non-canonical

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Stavenuiter, Fabian, and Laurent O. Mosnier. "Non-Canonical PAR3 Activation Induces Tie2-Dependent Endothelial Barrier Protective Effects." Blood 124, no. 21 (2014): 2802. http://dx.doi.org/10.1182/blood.v124.21.2802.2802.

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Abstract Introduction: Endothelial barrier protective effects of activated protein C (APC) require the endothelial protein C receptor (EPCR), protease activated receptor 1 (PAR1), and PAR3. In contrast, PAR1 and PAR3 activation by thrombin results in barrier disruption. Non-canonical PAR1 and PAR3 activation by APC versus canonical activation by thrombin provide an explanation for the functional selectivity of these proteases. APC induces non-canonical PAR3 activation at Arg41 and synthetic peptides representing the tethered-ligand sequence of PAR3 after non-canonical cleavage (P3R) induce bar

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Pitolli, Consuelo, Ying Wang, Eleonora Candi, Yufang Shi, Gerry Melino, and Ivano Amelio. "p53-Mediated Tumor Suppression: DNA-Damage Response and Alternative Mechanisms." Cancers 11, no. 12 (2019): 1983. http://dx.doi.org/10.3390/cancers11121983.

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The tumor suppressor p53 regulates different cellular pathways involved in cell survival, DNA repair, apoptosis, and senescence. However, according to an increasing number of studies, the p53-mediated canonical DNA damage response is dispensable for tumor suppression. p53 is involved in mechanisms regulating many other cellular processes, including metabolism, autophagy, and cell migration and invasion, and these pathways might crucially contribute to its tumor suppressor function. In this review we summarize the canonical and non-canonical functions of p53 in an attempt to provide an overview

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Minglibayev, M. Zh, and A. B. Kosherbayeva. "EQUATIONS OF PLANETARY SYSTEMS MOTION." SERIES PHYSICO-MATHEMATICAL 6, no. 334 (2020): 53–60. http://dx.doi.org/10.32014/2020.2518-1726.97.

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The study of the dynamically evolution of planetary systems is very actually in relation with findings of exoplanet systems. free spherical bodies problem is considered in this paper, mutually gravitating according to Newton's law, with isotropically variable masses as a celestial-mechanical model of non-stationary exoplanetary systems. The dynamic evolution of planetary systems is learned, when evolution's leading factor is the masses' variability of gravitating bodies themselves. The laws of the bodies' masses varying are assumed to be known arbitrary functions of time. When doing so the rat

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Eamens, Andrew L., Ki Wook Kim, and Peter M. Waterhouse. "DRB2, DRB3 and DRB5 function in a non-canonical microRNA pathway inArabidopsis thaliana." Plant Signaling & Behavior 7, no. 10 (2012): 1224–29. http://dx.doi.org/10.4161/psb.21518.

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Abedini, Atefeh, Gustavo Zamberlam, Derek Boerboom, and Christopher A. Price. "Non-canonical WNT5A is a potential regulator of granulosa cell function in cattle." Molecular and Cellular Endocrinology 403 (March 2015): 39–45. http://dx.doi.org/10.1016/j.mce.2015.01.017.

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Re, Dominic P. Del. "Hippo Signaling in the Heart – Non-Canonical Pathways Impact Growth, Survival and Function –." Circulation Journal 80, no. 7 (2016): 1504–10. http://dx.doi.org/10.1253/circj.cj-16-0426.

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Mignot, Sandra, Sandrine Delignat, Sebastien Lacroix-demaze, et al. "Non-Canonical MYD88/TIRAP-Dependent Anti-Inflammatory Function of Pro-Coagulant Factor VIII." Blood 134, Supplement_1 (2019): 3638. http://dx.doi.org/10.1182/blood-2019-127504.

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Context : FVIII is involved in the coagulation pathway. In the model developed by Hoffman in 1995, FVIII (with FIX) is at the center of coagulation. FVIII deficiency leads to a disease called hemophilia A. A deficiency of FVIII leads to inadequate coagulation and increases the risk of bleeding. Bleeding in hemophilic patient occurs mainly into large joints such as knee, elbow or ankle. Severe recurrence of hemarthrosis leads to irreversible arthropathy called hemophilic arthropathy (HA) characterized by a progressive complete destruction of the joint with permanent pain, musculoskeletal disabi

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Weaver, Benjamin P., Yi M. Weaver, Shizue Omi, Wang Yuan, Jonathan J. Ewbank, and Min Han. "Non-Canonical Caspase Activity Antagonizes p38 MAPK Stress-Priming Function to Support Development." Developmental Cell 53, no. 3 (2020): 358–69. http://dx.doi.org/10.1016/j.devcel.2020.03.015.

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Zhang, Yanjun, Ji-Feng Zhang, and Xiao-Kang Liu. "Implicit function based adaptive control of non-canonical form discrete-time nonlinear systems." Automatica 129 (July 2021): 109629. http://dx.doi.org/10.1016/j.automatica.2021.109629.

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Shi, Chun-Lin, and Yuan Hu Xuan. "OsEDR1 has non-canonical scaffold function in regulating MAPK cascade in plant immunity." Molecular Plant 14, no. 4 (2021): 555. http://dx.doi.org/10.1016/j.molp.2021.02.001.

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Siano, Giacomo, Chiara Falcicchia, Nicola Origlia, Antonino Cattaneo, and Cristina Di Primio. "Non-Canonical Roles of Tau and Their Contribution to Synaptic Dysfunction." International Journal of Molecular Sciences 22, no. 18 (2021): 10145. http://dx.doi.org/10.3390/ijms221810145.

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Tau plays a central role in a group of neurodegenerative disorders collectively named tauopathies. Despite the wide range of diverse symptoms at the onset and during the progression of the pathology, all tauopathies share two common hallmarks, namely the misfolding and aggregation of Tau protein and progressive synaptic dysfunctions. Tau aggregation correlates with cognitive decline and behavioural impairment. The mechanistic link between Tau misfolding and the synaptic dysfunction is still unknown, but this correlation is well established in the human brain and also in tauopathy mouse models.

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Cai, Bi-He, Chung-Faye Chao, Hsiang-Chi Huang, Hsueh-Yi Lee, Reiji Kannagi, and Jang-Yi Chen. "Roles of p53 Family Structure and Function in Non-Canonical Response Element Binding and Activation." International Journal of Molecular Sciences 20, no. 15 (2019): 3681. http://dx.doi.org/10.3390/ijms20153681.

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The p53 canonical consensus sequence is a 10-bp repeat of PuPuPuC(A/T)(A/T)GPyPyPy, separated by a spacer with up to 13 bases. C(A/T)(A/T)G is the core sequence and purine (Pu) and pyrimidine (Py) bases comprise the flanking sequence. However, in the p53 noncanonical sequences, there are many variations, such as length of consensus sequence, variance of core sequence or flanking sequence, and variance in number of bases making up the spacer or AT gap composition. In comparison to p53, the p53 family members p63 and p73 have been found to have more tolerance to bind and activate several of thes

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Yeo, Syn Kok, Chenran Wang, and Jun-Lin Guan. "Role of FIP200 in inflammatory processes beyond its canonical autophagy function." Biochemical Society Transactions 48, no. 4 (2020): 1599–607. http://dx.doi.org/10.1042/bst20191156.

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FIP200 (RB1CC1) is a critical regulator of canonical macroautophagy and has also emerged as a crucial regulator of selective autophagy as well as inflammatory processes. The illumination of FIP200's role in autophagy at the molecular level has been accompanied by studies demonstrating the importance of its autophagy function in physiological processes in mammals and pathological contexts such as cancer. However, there is an increasing appreciation that most, if not all of the autophagy genes, also play a role in other processes such as LC3-associated phagocytosis, vesicle trafficking and prote

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LI, HUI, ZONG-KUAN GUO, and YUAN-ZHONG ZHANG. "PARAMETRIZATION OF k-ESSENCE AND ITS KINETIC TERM." Modern Physics Letters A 21, no. 21 (2006): 1683–89. http://dx.doi.org/10.1142/s0217732306019475.

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We construct the non-canonical kinetic term of a k-essence field directly from the effective equation of state function wk(z), which describes the properties of the dark energy. Adopting the usual parametrizations of equation of state, we numerically reproduce the shape of the non-canonical kinetic term and discuss some features of the constructed form of k-essence.

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González-Magaña, Amaia, and Francisco J. Blanco. "Human PCNA Structure, Function and Interactions." Biomolecules 10, no. 4 (2020): 570. http://dx.doi.org/10.3390/biom10040570.

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Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes. It also interacts with regulatory proteins through a sequence motif known as PCNA Interacting Protein box (PIP-box). We here review the latest contributions to knowledge regarding the structure-function relationships in human PCNA, particularly the mechanism of sliding, and of the molecular recognition of canonical and non-canonical PIP motifs. The unique binding mode of t

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Perkowski, Marek A., Malgorzata Chrzanowska-Jeske, Andisheh Sarabi, and Ingo Schäfer. "Multi-Level Logic Synthesis Based on Kronecker Decision Diagrams and Boolean Ternary Decision Diagrams for Incompletely Specified Functions." VLSI Design 3, no. 3-4 (1995): 301–13. http://dx.doi.org/10.1155/1995/24594.

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This paper introduces several new families of decision diagrams for multi-output Boolean functions. The introduced families include several diagrams known from literature (BDDs, FDDs) as subsets. Due to this property, these diagrams can provide a more compact representation of functions than either of the two decision diagrams. Kronecker Decision Diagrams (KDDs) with negated edges are based on three orthogonal expansions (Shannon, Positive Davio, Negative Davio) and are created here for incompletely specified Boolean functions as well. An improved efficient algorithm for the construction of KD

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Duliban, M., A. Gurgul, T. Szmatola, et al. "Mouse testicular transcriptome after modulation of non-canonical oestrogen receptor activity." Reproduction, Fertility and Development 32, no. 10 (2020): 903. http://dx.doi.org/10.1071/rd20025.

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The aims of this study were to shed light on the role of G-protein-coupled membrane oestrogen receptor (GPER) and oestrogen-related receptor (ERR) in mouse testis function at the gene expression level, as well as the involvement of GPER and ERR in cellular and molecular processes. Male mice were injected (50µg kg−1,s.c.) with the GPER antagonist G-15, the ERRα inverse agonist XCT790 or the ERRβ/ERRγ agonist DY131. Next-generation sequencing (RNA-Seq) was used to evaluate gene expression. Bioinformatic analysis of read abundance revealed that 50, 86 and 171 transcripts were differentially expre

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Lamb, Maureen C., and Tina L. Tootle. "Fascin in Cell Migration: More Than an Actin Bundling Protein." Biology 9, no. 11 (2020): 403. http://dx.doi.org/10.3390/biology9110403.

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Fascin, an actin-binding protein, regulates many developmental migrations and contributes to cancer metastasis. Specifically, Fascin promotes cell motility, invasion, and adhesion by forming filopodia and invadopodia through its canonical actin bundling function. In addition to bundling actin, Fascin has non-canonical roles in the cell that are thought to promote cell migration. These non-canonical functions include regulating the activity of other actin-binding proteins, binding to and regulating microtubules, mediating mechanotransduction to the nucleus via interaction with the Linker of the

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Xia, Min, Liron David, Matthew Teater, et al. "BCL10 Gain-of-Function Mutations Aberrantly Induce Canonical and Non-Canonical NF-Kb Activation and Resistance to Ibrutinib in ABC-DLBCL." Blood 136, Supplement 1 (2020): 2–3. http://dx.doi.org/10.1182/blood-2020-141363.

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ABC-DLBCLs are among the most aggressive DLBCLs. Genome sequencing studies identified BCL10 gain-of-function mutations in DLBCL mostly within the ABC-DLBCLs. ABC-DLBCLs were recently split into further subtypes according to their genomic characteristics, among which BCL10 somatic mutations were most common in BN2/Cluster 1 cases. These are likely transformed marginal zone lymphomas and were recently suggested to be sensitive to ibrutinib treatment. Pooling publicly available data we noted that most BCL10 mutations are missense or nonsense SNVs affecting its CARD domain, MALT1 binding domain, a

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