Relevant bibliographies by topics / Non-canonical initiation codon

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  2. Dissertations / Theses

Academic literature on the topic 'Non-canonical initiation codon'

Author: Grafiati
Published: 14 September 2024
Last updated: 31 July 2025

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Journal articles on the topic "Non-canonical initiation codon"

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Firth, Andrew E., and Ian Brierley. "Non-canonical translation in RNA viruses." Journal of General Virology 93, no. 7 (2012): 1385–409. http://dx.doi.org/10.1099/vir.0.042499-0.

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Viral protein synthesis is completely dependent upon the translational machinery of the host cell. However, many RNA virus transcripts have marked structural differences from cellular mRNAs that preclude canonical translation initiation, such as the absence of a 5′ cap structure or the presence of highly structured 5′UTRs containing replication and/or packaging signals. Furthermore, whilst the great majority of cellular mRNAs are apparently monocistronic, RNA viruses must often express multiple proteins from their mRNAs. In addition, RNA viruses have very compact genomes and are under intense
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Prasad, Sharanya, Shelley Starck, and Nilabh Shastri. "Presentation of cryptic peptides by MHC I molecules is enhanced by inflammatory stimuli. (P5003)." Journal of Immunology 190, no. 1_Supplement (2013): 110.2. http://dx.doi.org/10.4049/jimmunol.190.supp.110.2.

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Abstract Cytolytic T cells eliminate infected cells by recognizing intracellular peptides presented by MHC class I molecules. The antigenic peptides are derived primarily from newly synthesized proteins including those produced by cryptic translation. Previous studies have shown that in addition to the canonical AUG codon, translation can be initiated at non-AUG codons . Furthermore, translation initiation at non-AUG codons such as CUG is mechanistically distinct from canonical translation initiation as it is resistant to protein synthesis inhibitors that cause global translation shutdown. Her
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Austin, Jermaine, Subin Myoong, Natalia Badnarek, and Sridevi Challa. "Abstract 1407: Alterations of EIF1AX and carboplatin treatment induce non-canonical translation initiation in ovarian cancer." Cancer Research 85, no. 8_Supplement_1 (2025): 1407. https://doi.org/10.1158/1538-7445.am2025-1407.

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Abstract Ovarian cancer (OvCa) is the deadliest gynecologic malignancy with high mortality due to chemoresistance. High grade serous ovarian cancer (HGSOC) is the most common subtype of ovarian cancer. The standard of care for women with HGSOC is cytoreductive surgery and chemotherapy using carboplatin, which causes DNA damage and oxidative stress. Despite aggressive treatment strategies, most patients with high grade HGSOC relapse. We recently demonstrated that post-translational modification of ribosomal proteins affects mRNA translation and protein homeostasis in ovarian cancer cells by reg
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Coldwell, Mark J., Ulrike Sack, Joanne L. Cowan, et al. "Multiple isoforms of the translation initiation factor eIF4GII are generated via use of alternative promoters, splice sites and a non-canonical initiation codon." Biochemical Journal 448, no. 1 (2012): 1–11. http://dx.doi.org/10.1042/bj20111765.

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During the initiation stage of eukaryotic mRNA translation, the eIF4G (eukaryotic initiation factor 4G) proteins act as an aggregation point for recruiting the small ribosomal subunit to an mRNA. We previously used RNAi (RNA interference) to reduce expression of endogenous eIF4GI proteins, resulting in reduced protein synthesis rates and alterations in the morphology of cells. Expression of EIF4G1 cDNAs, encoding different isoforms (f–a) which arise through selection of alternative initiation codons, rescued translation to different extents. Furthermore, overexpression of the eIF4GII paralogue
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Graça, Rafael, Rafael Fernandes, Ana Catarina Alves, Juliane Menezes, Luísa Romão, and Mafalda Bourbon. "Characterization of Two Variants at Met 1 of the Human LDLR Gene Encoding the Same Amino Acid but Causing Different Functional Phenotypes." Biomedicines 9, no. 9 (2021): 1219. http://dx.doi.org/10.3390/biomedicines9091219.

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Familial hypercholesterolemia (FH) is the most common genetic disorder of lipid metabolism, characterized by increased levels of total and LDL plasma cholesterol, which leads to premature atherosclerosis and coronary heart disease. FH phenotype has considerable genetic heterogeneity and phenotypic variability, depending on LDL receptor activity and lifestyle. To improve diagnosis and patient management, here, we characterized two single nucleotide missense substitutions at Methionine 1 of the human LDLR gene (c.1A>T/p.(Met1Leu) and c.1A>C/p.(Met1Leu)). We used a combination of Western bl
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Gao, Fei, Maria Wesolowska, Reuven Agami, et al. "Using mitoribosomal profiling to investigate human mitochondrial translation." Wellcome Open Research 2 (December 11, 2017): 116. http://dx.doi.org/10.12688/wellcomeopenres.13119.1.

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Background: Gene expression in human mitochondria has various idiosyncratic features. One of these was recently revealed as the unprecedented recruitment of a mitochondrially-encoded tRNA as a structural component of the large mitoribosomal subunit. In porcine particles this is mt-tRNAPhe whilst in humans it is mt-tRNAVal. We have previously shown that when a mutation in mt-tRNAVal causes very low steady state levels, there is preferential recruitment of mt-tRNAPhe. We have investigated whether this altered mitoribosome affects intra-organellar protein synthesis. Methods: By using mitoribosoma
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Gao, Fei, Maria Wesolowska, Reuven Agami, et al. "Using mitoribosomal profiling to investigate human mitochondrial translation." Wellcome Open Research 2 (January 29, 2018): 116. http://dx.doi.org/10.12688/wellcomeopenres.13119.2.

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Background: Gene expression in human mitochondria has various idiosyncratic features. One of these was recently revealed as the unprecedented recruitment of a mitochondrially-encoded tRNA as a structural component of the large mitoribosomal subunit. In porcine particles this is mt-tRNAPhe whilst in humans it is mt-tRNAVal. We have previously shown that when a mutation in mt-tRNAVal causes very low steady state levels, there is preferential recruitment of mt-tRNAPhe. We have investigated whether this altered mitoribosome affects intra-organellar protein synthesis. Methods: By using mitoribosoma
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8

Fecher-Trost, Claudia, Ulrich Wissenbach, Andreas Beck, et al. "The in Vivo TRPV6 Protein Starts at a Non-AUG Triplet, Decoded as Methionine, Upstream of Canonical Initiation at AUG." Journal of Biological Chemistry 288, no. 23 (2013): 16629–44. http://dx.doi.org/10.1074/jbc.m113.469726.

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TRPV6 channels function as epithelial Ca2+ entry pathways in the epididymis, prostate, and placenta. However, the identity of the endogenous TRPV6 protein relies on predicted gene coding regions and is only known to a certain level of approximation. We show that in vivo the TRPV6 protein has an extended N terminus. Translation initiates at a non-AUG codon, at ACG, which is decoded by methionine and which is upstream of the annotated AUG, which is not used for initiation. The in vitro properties of channels formed by the extended full-length TRPV6 proteins and the so-far annotated and smaller T
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9

Jewett, Mollie W., Sunny Jain, Angelika K. Linowski, Amit Sarkar, and Patricia A. Rosa. "Molecular characterization of the Borrelia burgdorferi in vivo-essential protein PncA." Microbiology 157, no. 10 (2011): 2831–40. http://dx.doi.org/10.1099/mic.0.051706-0.

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The conversion of nicotinamide to nicotinic acid by nicotinamidase enzymes is a critical step in maintaining NAD+ homeostasis and contributes to numerous important biological processes in diverse organisms. In Borrelia burgdorferi, the nicotinamidase enzyme, PncA, is required for spirochaete survival throughout the infectious cycle. Mammals lack nicotinamidases and therefore PncA may serve as a therapeutic target for Lyme disease. Contrary to the in vivo importance of PncA, the current annotation for the pncA ORF suggests that the encoded protein may be inactive due to the absence of an N-term
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10

Paudel, Dinesh Babu, and Hélène Sanfaçon. "Mapping of sequences in the 5’ region and 3’ UTR of tomato ringspot virus RNA2 that facilitate cap-independent translation of reporter transcripts in vitro." PLOS ONE 16, no. 4 (2021): e0249928. http://dx.doi.org/10.1371/journal.pone.0249928.

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Tomato ringspot virus (ToRSV, genus Nepovirus, family Secoviridae, order Picornavirales) is a bipartite positive-strand RNA virus, with each RNA encoding one large polyprotein. ToRSV RNAs are linked to a 5’-viral genome-linked protein (VPg) and have a 3’ polyA tail, suggesting a non-canonical cap-independent translation initiation mechanism. The 3’ untranslated regions (UTRs) of RNA1 and RNA2 are unusually long (~1.5 kb) and share several large stretches of sequence identities. Several putative in-frame start codons are present in the 5’ regions of the viral RNAs, which are also highly conserv
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Dissertations / Theses on the topic "Non-canonical initiation codon"

1

Condé, Lionel. "Contrôle traductionnel du SARS-CoV-2." Electronic Thesis or Diss., Lyon, École normale supérieure, 2024. http://www.theses.fr/2024ENSL0010.

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Endant l’infection virale, la régulation de l’expression des gènes est au cœur des interactions complexes entre l'hôte et le pathogène. Les virus exploitent la machinerie cellulaire de l'hôte pour assurer la synthèse de leurs protéines nécessaires pour la réplication et la propagation de l'infection. C'est notamment le cas lors de l'infection par le SARS-CoV-2, qui induit rapidement une inhibition globale de la traduction cellulaire grâce à l'action de facteurs viraux tels que la protéine Nsp1. Pour produire efficacement ses protéines, le virus doit alors mettre en place des stratégies pour co
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2

Knight, Helen Coral. "Alternative non-canonical translation initiation codons are used to synthesise novel isoforms of the transcription factor GATAD1." Thesis, University of Southampton, 2017. https://eprints.soton.ac.uk/413444/.

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Alternative translation initiation from upstream non-AUG codons contributes towards the diversity of the eukaryotic proteome; protein isoforms with varying N-terminal extensions can be generated from one mRNA transcript. Investigations are being carried out in order to elucidate how N-terminal extensions affect subcellular localisation, binding partners and thus the function of a protein as well as how the choice of alternative initiation codon (AIC) is regulated. This thesis is focussed on GATAD1 (GATA Zinc Finger Domain-Containing 1), which is a ubiquitously expressed transcription factor, f
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