Academic literature on the topic 'Non-clinical studies'

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Journal articles on the topic "Non-clinical studies"

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Sitruk-Ware, R. "Non-clinical studies of progesterone." Climacteric 21, no. 4 (2018): 315–20. http://dx.doi.org/10.1080/13697137.2018.1463982.

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Swanson, Steven J., and Jeanine Bussiere. "Immunogenicity assessment in non-clinical studies." Current Opinion in Microbiology 15, no. 3 (2012): 337–47. http://dx.doi.org/10.1016/j.mib.2012.05.015.

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Molinier, B., M. Henriquet, N. Fourcine, and B. Remandet. "Functional immunotoxicity assays in non-clinical studies." Toxicology Letters 205 (August 2011): S149. http://dx.doi.org/10.1016/j.toxlet.2011.05.528.

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Franco, Raúl, Juan M. Rodriguez, Fernanda Elías, et al. "Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide." Nucleic Acid Therapeutics 24, no. 4 (2014): 267–82. http://dx.doi.org/10.1089/nat.2013.0479.

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Le Tourneau, C., M. Kamal, O. Tredan, et al. "Poster session 7. Clinical Studies - non-phase 1." Annals of Oncology 24, suppl 1 (2013): i36. http://dx.doi.org/10.1093/annonc/mdt049.

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Singer, C. R. J., and A. H. Goldstone. "Clinical studies of ABMT in non-Hodgkin's lymphoma." Clinics in Haematology 15, no. 1 (1986): 105–50. http://dx.doi.org/10.1016/s0308-2261(86)80008-x.

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AWAZU, Shoji. "ISSUES ABOUT CURRENT “GUIDELINES FOR NON - CLINICAL PHARMACOKINETIC STUDIES”." Drug Metabolism and Pharmacokinetics 11, supplement (1996): 5126–27. http://dx.doi.org/10.2133/dmpk.11.supplement_5126.

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AWAZU, Shoji. "Issues about Current "Guidelines for Non-Clinical Pharmacokinetic Studies"." Drug Metabolism and Pharmacokinetics 12, no. 3 (1997): 217–18. http://dx.doi.org/10.2133/dmpk.12.217.

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Parnham, Michael J., Janice Schindler-Horvat, and Marija Kozlović. "Non-Clinical Safety Studies on Biosimilar Recombinant Human Erythropoietin." Basic & Clinical Pharmacology & Toxicology 100, no. 2 (2007): 73–83. http://dx.doi.org/10.1111/j.1742-7843.2007.00028.x.

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SCHMITT, GERHARD J. "Principles for the conduct of non-drug clinical studies." International Journal of Cosmetic Science 16, no. 1 (1994): 39–43. http://dx.doi.org/10.1111/j.1467-2494.1994.tb00080.x.

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Dissertations / Theses on the topic "Non-clinical studies"

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Peterson, Colleen Margaret. "Couple Cohesion: Differences Between Clinical and Non-Clinical Mormon Couples." Diss., CLICK HERE for online access, 1988. http://patriot.lib.byu.edu/u?/MTNZ,10566.

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Reid, Tracey J. S. "Obsessions and compulsions : electrophysiological studies in a non-clinical population." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282300.

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Axelsson, Birger. "Cardiac effects of non-adrenergic inotropic drugs : clinical and experimental studies." Doctoral thesis, Umeå universitet, Anestesiologi och intensivvård, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68967.

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Background: Myocardial failure and dysfunction is not uncommon during critical illness and following cardiac surgery. For optimal treatment, a better understanding of the effects of inotropic drugs is needed. In this thesis, two non-adrenergic mediated inotropes, milrinone and levosimendan were studied in different models of myocardial dysfunction. The study aims were to assess the following: the effects of milrinone on blood flow in coronary artery bypass grafts during CABG surgery; the effects of milrinone on left ventricular diastolic function during post-ischaemic myocardial dysfunction; w
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Pereira, Stephen Paul. "The pathogenesis and non-surgical treatment of gallstones : clinical and laboratory studies." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271458.

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Ösby, Eva. "Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-563-8/.

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Webb, M’Balu Alena. "Studies into the efficacy of using non-purified islets for clinical islet transplantation." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10071.

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Islet purification prior to allo transplantation currently forms the clinical gold standard, despite the fact that purification protocols result in significant islet losses and remove potential islet precursors and tissue that may provide islets with bio-trophic support Conversely, non-purified islet preparations retain endocrine mass and within the sphere of islet auto transplantation have been associated with excellent long-term graft function. This study comprises of an analysis of peri-operative factors and the long-term graft function of patients’ auto transplanted with either purified (n
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Moorthy, Ganesh. "Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-clinical Mechanistic Assessment." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439296033.

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Rafi, Imran. "Phase I clinical and pharmacological studies with the non-classical thymidylate synthase inhibitor AG337." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265431.

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Twati, Wageh. "Studies on materials and techniques to enhance clinical outcomes for non-vital immature permanent incisors." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5339/.

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In this thesis three studies are presented all aimed at enhancing outcomes for the endodontic management of non-vital immature permanent incisors. Study 1. Aim: To study the effect of non-setting calcium hydroxide (NSCH) and mineral trioxide aggregate (MTA) on mechanical properties of dentine. Methodology: Approval was obtained from the Tissue bank of the Leeds Dental Institute for the use of human teeth for this study. Twenty-seven human premolar teeth were sectioned to give a total of 54 dentine slabs. Nine slabs used in each group for each of the two time periods: 3 months and 8 months. A t
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Booster, Maurits Harm. "The Non-Heart Beating donor, a new source of kidneys for transplantation clinical and experimental studies /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6644.

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Books on the topic "Non-clinical studies"

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International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. and Canada Therapeutic Products Directorate, eds. Timing of non-clinical safety studies for the conduct of human clinical trials for pharmaceuticals. Therapeutic Products Directorate, Health Canada, 1997.

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Bartu, Anne. Evaluation of a preventative intervention strategy in a non-clinical setting using computerised screening. Western Australian Alcohol & Drug Authority, 1991.

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M, Burns Suzanne, and American Association of Critical-Care Nurses., eds. AACN protocols for practice. 2nd ed. Jones and Bartlett Publishers, 2006.

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Giffney, Noreen. Developing Clinical Insight Using Non-Clinical Case Studies in Psychoanalysis and Psychotherapy. Taylor & Francis Group, 2021.

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Giffney, Noreen. Developing Clinical Insight Using Non-Clinical Case Studies in Psychoanalysis and Psychotherapy. Taylor & Francis Group, 2021.

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Food and Drug Administration Staff. Compact Regs - Good Laboratory Practice for Non-Clinical Laboratory Studies. Taylor & Francis Group, 2004.

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Beckett, Ronald G., Gerald J. Conlogue, and Andrew J. Nelson. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. CRC Press, 2020. http://dx.doi.org/10.4324/9780429318597.

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Nelson, Andrew, Ronald G. Beckett, and Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Nelson, Andrew, Ronald G. Beckett, and Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Beckett, Ronald G., Andrew J. Nelson, and Gerald J. Conlogue. Case Studies for Advances in Paleoimaging and Other Non-Clinical Applications. Taylor & Francis Group, 2020.

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Book chapters on the topic "Non-clinical studies"

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Foster, John R., Vasanthi Mowat, and Chirukandath Gopinath. "Differentiating Adverse and Non-Adverse Findings in Non-Clinical Studies." In Current Topics in Nonclinical Drug Development. CRC Press, 2023. http://dx.doi.org/10.1201/9781003035800-3.

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Ferguson, Ryan E., and Mary T. Brophy. "Pilot Studies." In Clinical Trials Design in Operative and Non Operative Invasive Procedures. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53877-8_27.

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Macleod, Malcolm R., Ezgi Tanriver-Ayder, Kaitlyn Hair, and Emily Sena. "Design of Meta-Analysis Studies." In Good Research Practice in Non-Clinical Pharmacology and Biomedicine. Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_289.

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Jackson, Michael R., and Jack H. Dean. "The minimum non-clinical package for initiating Phase I clinical trials." In The Timing of Toxicological Studies to Support Clinical Trials. Springer Netherlands, 1994. http://dx.doi.org/10.1007/978-94-011-1424-0_10.

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Lopez, Nicole E., and Lawrence T. Kim. "Quality Control in Procedural Studies." In Clinical Trials Design in Operative and Non Operative Invasive Procedures. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-53877-8_26.

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Levy, M. "Non-Steroidal Anti-Inflammatory Drugs: Epidemiological Studies of Adverse Reactions." In Adverse Reactions to Non-Steroidal Anti-Inflammatory Drugs: Clinical Pharmacoepidemiology. Birkhäuser Basel, 1992. http://dx.doi.org/10.1007/978-3-0348-5722-2_4.

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Moser, Paul. "Out of Control? Managing Baseline Variability in Experimental Studies with Control Groups." In Good Research Practice in Non-Clinical Pharmacology and Biomedicine. Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_280.

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Sukoff Rizzo, Stacey J., Stephanie McTighe, and David L. McKinzie. "Genetic Background and Sex: Impact on Generalizability of Research Findings in Pharmacology Studies." In Good Research Practice in Non-Clinical Pharmacology and Biomedicine. Springer International Publishing, 2019. http://dx.doi.org/10.1007/164_2019_282.

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Heim, Manfred E., Henning Flechtner, and Bernhard K. Keppler. "Clinical Studies with Budotitane — A New Non-Platinum Metal Complex for Cancer Therapy." In Ruthenium and Other Non-Platinum Metal Complexes in Cancer Chemotherapy. Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74760-1_10.

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Szilagyi, Erzsebet, Nadim Mahmud, and Amelia Bartholomew. "The Importance of Non-Human Primate Models for Pre-clinical Studies in Hematopoiesis." In Allogeneic Stem Cell Transplantation. Humana Press, 2009. http://dx.doi.org/10.1007/978-1-59745-478-0_43.

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Conference papers on the topic "Non-clinical studies"

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Zhu, Caigang. "Non-Contact Optical Spectroscopy for Tumor-Sensitive Diffuse Reflectance and Fluorescence Measurements on Murine Subcutaneous Tissue Models." In Clinical and Translational Biophotonics. Optica Publishing Group, 2024. https://doi.org/10.1364/translational.2024.tw1b.1.

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We reported a novel Monte Carlo method to simulate a non-contact setup for both diffuse reflectance and fluorescence measurements on murine subcutaneous tissue models. Tissue-mimicking phantom studies were further conducted to solidify the key numerical findings. Full-text article not available; see video presentation
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Cunha, Matheus Almeida Ribeiro da, João Gustavo dos Anjos Morais Oliveira, Gabriela Sarno Brandão, et al. "Clinical effects of nonpharmacological treatment of ADHD." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.488.

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Background: Though pharmacotherapy of Attention Deficit Hyperactivity Disorder (ADHD) is widespread, some patients suffer with side effects or do not improve with it. Objectives: Evaluate clinical outcomes of non-pharmacological therapy on ADHD. Design and Setting: This is a literature review, produced in Bahiana School of Medicine and Public Health. Methods: Articles published between 2011 and 2021 were taken from PubMed, using the following search: (“Non-pharmacological treatment” OR “Non- pharmacological therapy” OR “Non-pharmacological intervention” OR “Non-drug treatment” OR “Non-drug the
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Dominguez, Manuel Carro, Clodagh O'Keeffe, Eugene O'Rourke, Niamh Feerick, and Richard B. Reilly. "Cortical Theta Activity and Postural Control in Non-Visual and High Cognitive Load Tasks: Impact for Clinical Studies." In 2019 41st Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2019. http://dx.doi.org/10.1109/embc.2019.8857663.

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Zheng, Yanxin, Runbin Yan, Yuxin Tang, et al. "Abstract 2597: Non-clinical studies of systemic delivery of oncolytic virus arms with IL-12 and anti-PD-1 antibody." In Proceedings: AACR Annual Meeting 2021; April 10-15, 2021 and May 17-21, 2021; Philadelphia, PA. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.am2021-2597.

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Fernandes, Lucca Ferdinando Queiroz, Raiana Carol de Medeiros Dantas, Maria Clara Medeiros Araújo, and Lucas de Oliveira Araújo Andrade. "Non-motor clinical manifestations of Parkinson’s disease and its relevance in early diagnosis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.100.

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Introduction: Parkinson’s disease is a progressive neurodegenerative disease that affects millions of people worldwide. Although Parkinson’s disease has traditionally been described as a disorder of the motor system, it is now recognized as a complex disease with several clinical features that include neuropsychiatric and non-motor manifestations. Studies show that 97% of patients with Parkinson’s disease report non-motor symptoms, in addition to motor symptoms, and some non-motor characteristics may appear before classic motor signs. Objectives: To list the main non-motor clinical manifestati
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de Oliveira Martins Monteiro, Ana Luiza, Laura de Alvarenga Oliveira, Lívia da Silva Terra, Mariana Cristina da Silva Pinheiro, Thalita de Souza Ramos, and Luciano Matos Chicayban. "Effects of shock wave therapy on pain in patients with lateral epicondylitis." In 7th International Congress on Scientific Knowledge. Biológicas & Saúde, 2021. http://dx.doi.org/10.25242/8868113820212389.

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Repetitive work or sports activities can cause lateral epicondylitis, causing pain, edema and consequent functional reduction. Shockwave therapy is a non-invasive treatment that consists of using shockwavesin musculoskeletal areas in order to reduce pain and promote soft tissue healing. Identify the effects of shockwave therapy in patients with lateral epicondylitis. Through a systematic review of the literature, randomized clinical trials published among 2002 and 2012, according to the highest score on the PEDro score. The search involved the PEDro and PubMed databases. Six randomized clinica
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Vila, Arber, Mohammad Ahmed, Amirtaha Taebi, Pengfei Dong, Linxia Gu, and Peshala Thibbotuwawa Gamage. "A Reduced Order Model for Estimation of Fractional Flow Reserve (FFR) in Coronary Artery Disease: Assessing the Impact of Side Branches." In ASME 2023 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2023. http://dx.doi.org/10.1115/imece2023-112632.

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Abstract Millions of people worldwide are affected by coronary artery disease (CAD), which is a major cause of morbidity and mortality. To plan effective treatment and stratify risk, it is crucial to evaluate the severity of CAD. Fractional flow reserve (FFR) is a vital parameter used in clinical practice to evaluate CAD severity, which measures the ratio of mean distal coronary pressure to mean aortic pressure during hyperemic conditions. Non-invasive methods for estimating FFR have gained popularity, but computational fluid dynamics (CFD), which is often used, is impractical for routine clin
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Klaessens, John H. G. M., Martin Nelisse, Rudolf M. Verdaasdonk, and Herke Jan Noordmans. "Non-contact tissue perfusion and oxygenation imaging using a LED based multispectral and a thermal imaging system, first results of clinical intervention studies." In SPIE BiOS, edited by Anita Mahadevan-Jansen, Tuan Vo-Dinh, and Warren S. Grundfest. SPIE, 2013. http://dx.doi.org/10.1117/12.2003807.

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Rezende, Karla Viana, Ayrton Senna do Brasil Amaral Alves, Juliana Carollyne Amorim, Maria Inês Vaz de Oliveira, Maria Paula Banhara Rodrigues, and Vitor Matias Grah. "Helminth-induced immune response: A new perspective for the treatment of Multiple Sclerosis." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.603.

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Background: Multiple Sclerole (MS) is a progressive neurodegenerative disease that, in its most common form, evolves in outbreaks and compromises the patient’s quality of life and functionality. In a long time, a way of attenuating symptoms and preventing the progression of this pathology has been studied, however, drug therapies, until now, have not shown good accuracy. In this context, the exogenous use of helminths as non-drug therapy for MS has been considered, therefore, this study aims to demonstrate the recent results of studies on such therapies and verify whether there is scientific e
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Silva, Gustavo Figueiredo da, Caroline Figueiredo da Silva, Washigton Luiz Gomes de Medeiros Junior, and Marcus Vinícius Magno Gonçalves. "Anti -Iglon5 Syndrome: What we know so far? A non-systematic review." In XIII Congresso Paulista de Neurologia. Zeppelini Editorial e Comunicação, 2021. http://dx.doi.org/10.5327/1516-3180.237.

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Background: The first report of Anti-IgLON5 syndrome was in 2014. AntiIgLON5 antibodies have a prevalence of 12 in 150,000 patients per year. However, considering the unreported patients, the prevalence can be much higher. Objectives: Provide an overview of the current knowledge of Anti- IgLON5 syndrome. Design and setting: Narrative review. Methods: Non- systematic review on Pubmed database. Results: The IgLON proteins are a family of cell adhesion molecules and the presence of antibodies against IgLON5 is crucial for the AntiIgLON5 Syndrome diagnosis. This syndrome has an expanded clinical s
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Reports on the topic "Non-clinical studies"

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Peng, Yinglong, Jinwei Chen, Ziyan Wang, Yihui Cao, and Jie Zhao. A Systematic Review and meta-analysis of the efficacy of immunotherapy in the treatment of non-small cell lung cancer. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.6.0094.

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Review question / Objective: This study aimed to compare the effectiveness of different ICIs in the treatment of NSCLC, and to provide a theoretical basis for clinical selection of different regimens. Condition being studied: Immunotherapy is a relatively new treatment method for non-small cell lung cancer (NSCLC), and clinical studies confirmed that immune checkpoint inhibitors (ICIs) showed prominent efficacy in the treatment of NSCLC patients. This study aimed to compare the effectiveness of different ICIs in the treatment of NSCLC, and to provide a theoretical basis for clinical selection
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López-Valverde, Nansi, Antonio López-Valverde, and Jose Antonio Blanco-Rueda. Efficacy of metronidazole on peri-implantitis: A systematic review and meta-analysis of randomized studies. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.1.0015.

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Review question / Objective: In patients with peri-implantitis, is adjuvant local or systemic treatment with metronidazole effective on signs of inflammation and bone destruction? Eligibility criteria: Inclusion criteria: a) RCTs (single or double-blind) performed in patients with peri-implantitis defined as bleeding and/or suppuration on peri-implant probing (≥ 4 mm).b) Studies comparing the efficacy of local/systemic metronidazole adjuvant therapy vs. single surgical or non-surgical treatmentc) Articles published in English.Exclusion criteria: a) Less than five patients per treatment group.b
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Petrunoff, Nick, Bess Jackson, Samuel Harley, et al. Non-clinical interventions and services for individuals with suicide distress or crisis: an Accelerated Evidence Snapshot. The Sax Institute, 2025. https://doi.org/10.57022/fknj4927.

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The NSW Suicide Monitoring System recorded 933 suspected or confirmed suicide deaths in 2023, highlighting the need for effective prevention strategies. The Towards Zero Suicides (TZS) initiative funds non-clinical crisis services like Safe Havens and Suicide Prevention Outreach Teams (SPOTs), providing peer-led, community-based support to individuals in distress. This Evidence Check aimed to evaluate the effectiveness and acceptability of such interventions for people aged 16 and over, informing potential refinements or new approaches in NSW. Fifteen studies from Australia, the US, Canada, De
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DE ANDRADE, RAUL RIBEIRO, OLAVO BARBOSA DE OLIVEIRA NETO, JOÃO GUSTAVO ROCHA PEIXOTO DOS SANTOS, CÉLIO FERNANDO DE SOUSA RODRIGUES, and FABIANO TIMBÓ BARBOSA. Effectiveness of Early Tracheostomy compared with Late Tracheostomy Or Prolonged Orotracheal Intubation in Traumatic Brain Injury: Protocol of Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.1.0051.

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Review question / Objective: What is the effectiveness of Early Tracheostomy compared with Late Tracheostomy Or Prolonged Orotracheal Intubation in Traumatic Brain Injury? Condition being studied: Traumatic Brain Injury (TBI) is every traumatic anatomical ou functional injury that affects brain, skull and/or vessels related to them. TBI is a public health problem that involves over 50 million people per year in Worldwide. Information sources: PUBLISHED DATABASES (Medline by PUBMED, Lilacs, Central-Cochrane, Scopus by Elsevier, Web Of Science e Embase by Elsevier) NON-PUBLISHED (Open Grey by Si
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Cajas, María Augusta, Marcela Cabrera, Jaime Astudillo, Yulissa Abad, and Daniela Astudillo. Accuracy in marginal and/or internal adaptation of full-coverage fixed prostheses made with digital versus conventional impressions: an overview of systematic reviews and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.10.0024.

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Review question / Objective: Is the accuracy (marginal adaptation and / or internal adaptation) of fixed full coverage prostheses made with digital impressions better than conventional impressions? Eligibility criteria: Inclusion criteria• Systematic reviews and / or meta-analyzes that evaluated the precision (marginal adaptation and / or internal adaptation) of full coverage fixed prostheses on natural teeth in clinical studies and on tooth replicas in in vitro studies.• Systematic reviews and / or meta-analyzes comparing digital impressions with an intraoral scanner versus conventional impre
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Zhao, Qing, and Lili Zhou. Culture, sex, and their combined impact on self-report empathy—Meta-analyses. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.4.0172.

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Condition being studied: The current meta-analysis covers empirical investigations of self-report empathy (evaluated using the EQ and the IRI scales) based on different populations. Studies with general populations and physical/mental clinical populations were included. Both cross-cultural and non-cross-cultural studies (studies based on a single cultural background) were considered. Eligibility criteria: We restricted our current meta-analysis to studies that satisfied all of the following criteria: (1) studies evaluated participants’ self-report empathy using the EQ or the IRI; (2) studies r
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Silva, Rodrigo Ribeiro e., Mateus de Miranda Gauza, Julia Opolski Nunes da Silva Opolski, and Maria Eduarda Schramm Guisso. Once-Weekly Insulin Icodec vs Once-Daily Insulin Glargine U100 for Type 2 Diabetes: A Meta-analysis of Phase 2 Randomized Controlled Trials. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.5.0102.

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Review question / Objective: To compare Once-Weekly Insulin Icodec and Once-Daily Insulin Glargine U100 in patients with Type 2 Diabetes Mellitus using oral hypoglycemic drugs in need of insulin therapy. Condition being studied: Patients with Diabetes Mellitus Type 2 using oral hypoglycemic drugs in need for basal insulin. Eligibility criteria: Inclusion in this meta-analysis was restricted to studies that met all the following criteria: (1) randomized trials; (2) comparing the use once weekly insulin icodec to once daily insulin glargine; (3) enrolling patients with type 1 or type 2 diabetes
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Dias, Rita, Miguel Rocha, Lucía Manrique, Sílvia Fraga, and Paula Meireles. HIV Prevention Combination Among Men who have Sex with Men: a scoping review protocol. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2022. http://dx.doi.org/10.37766/inplasy2022.10.0071.

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Review question / Objective: To map the evidence regarding the combination of prevention strategies used by MSM to manage their HIV risk, assessing how this has been studied and how HIV prevention strategies are being combined by MSM. Eligibility criteria: We will include published scientific documents found through the search expression in the Web of Science, PubMed, and Scopus databases, about HIV prevention in HIV negative MSM. Studies about non-human animals and females will be excluded, as well as non-scientific documents and reports, editorials, opinion papers, comments, revisions, or jo
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Wu, Chiu-Feng, Tzu-Pei Yeh, Tzu-Chen Lin, Po-Hsiang Huang, and Pin-Jui Huang. Effects of far infrared therapy in Hemodialysis Arterio-Venous Fistula Maturation: A Meta-analysis and Systematic Review. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2023. http://dx.doi.org/10.37766/inplasy2023.4.0020.

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Review question / Objective: Participant Type: Only for any ESRD patient diagnosed with CKD and established AVF and requiring regular HD treatment with AVF. Intervention type: Studies using FIR therapy versus non- FIR therapy. Outcome Measure Types: Fistula maturation, patency, access blood flow, AVF I.D.; fistula occlusion. P: Patients under hemodialysis. Condition being studied: Far infrared is an invisible electromagnetic wave. Far infrared therapy (FIR) uses low-power electromagnetic waves emitted by FIR with wavelengths of 3-100 µm to improve human physiological functions. Previous studie
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Gupta, Tejpal, Riddhijyoti Talukdar, Sadhana Kannan, Archya Dasgupta, Abhishek Chatterjee, and Vijay Patil. Meta-Analysis of Standard Temozolomide versus Extended Adjuvant Temozolomide following concurrent Radiochemotherapy in newly-diagnosed Glioblastoma (MASTER-G). INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2021. http://dx.doi.org/10.37766/inplasy2021.12.0114.

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Review question / Objective: To assess the safety and efficacy of extended adjuvant temozolomide compared to standard adjuvant temozolomide after concurrent radiochemotherapy in patients with newly-diagnosed glioblastoma. Condition being studied: Newly-diagnosed glioblastoma. Eligibility criteria: Prospective clinical trials randomly assigning patients to extended (>6-cycles) adjuvant TMZ (experimental arm) or standard (6-cycles) adjuvant TMZ will be included. Randomization in an individual study may have been done upfront before concurrent phase (RT/TMZ), after completion of concurrent RT/
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