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Dissertations / Theses on the topic 'Non-clinical studies'

Author: Grafiati

Published: 25 May 2024

Last updated: 31 July 2025

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1

Peterson, Colleen Margaret. "Couple Cohesion: Differences Between Clinical and Non-Clinical Mormon Couples." Diss., CLICK HERE for online access, 1988. http://patriot.lib.byu.edu/u?/MTNZ,10566.

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Reid, Tracey J. S. "Obsessions and compulsions : electrophysiological studies in a non-clinical population." Thesis, Queen's University Belfast, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282300.

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3

Axelsson, Birger. "Cardiac effects of non-adrenergic inotropic drugs : clinical and experimental studies." Doctoral thesis, Umeå universitet, Anestesiologi och intensivvård, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-68967.

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Background: Myocardial failure and dysfunction is not uncommon during critical illness and following cardiac surgery. For optimal treatment, a better understanding of the effects of inotropic drugs is needed. In this thesis, two non-adrenergic mediated inotropes, milrinone and levosimendan were studied in different models of myocardial dysfunction. The study aims were to assess the following: the effects of milrinone on blood flow in coronary artery bypass grafts during CABG surgery; the effects of milrinone on left ventricular diastolic function during post-ischaemic myocardial dysfunction; w

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4

Pereira, Stephen Paul. "The pathogenesis and non-surgical treatment of gallstones : clinical and laboratory studies." Thesis, King's College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271458.

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5

Ösby, Eva. "Clinical studies in aggressive non-Hodgkin's lymphoma with special reference to elderly patients /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-563-8/.

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6

Webb, M’Balu Alena. "Studies into the efficacy of using non-purified islets for clinical islet transplantation." Thesis, University of Leicester, 2011. http://hdl.handle.net/2381/10071.

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Islet purification prior to allo transplantation currently forms the clinical gold standard, despite the fact that purification protocols result in significant islet losses and remove potential islet precursors and tissue that may provide islets with bio-trophic support Conversely, non-purified islet preparations retain endocrine mass and within the sphere of islet auto transplantation have been associated with excellent long-term graft function. This study comprises of an analysis of peri-operative factors and the long-term graft function of patients’ auto transplanted with either purified (n

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7

Moorthy, Ganesh. "Clinical Pharmacokinetics of the Novel Combination of BEZ235, PI3K/mTOR Inhibitor, and Everolimus, mTOR Inhibitor: Phase I Clinical Studies and Non-clinical Mechanistic Assessment." University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439296033.

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8

Rafi, Imran. "Phase I clinical and pharmacological studies with the non-classical thymidylate synthase inhibitor AG337." Thesis, University of Newcastle Upon Tyne, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.265431.

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9

Twati, Wageh. "Studies on materials and techniques to enhance clinical outcomes for non-vital immature permanent incisors." Thesis, University of Leeds, 2013. http://etheses.whiterose.ac.uk/5339/.

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In this thesis three studies are presented all aimed at enhancing outcomes for the endodontic management of non-vital immature permanent incisors. Study 1. Aim: To study the effect of non-setting calcium hydroxide (NSCH) and mineral trioxide aggregate (MTA) on mechanical properties of dentine. Methodology: Approval was obtained from the Tissue bank of the Leeds Dental Institute for the use of human teeth for this study. Twenty-seven human premolar teeth were sectioned to give a total of 54 dentine slabs. Nine slabs used in each group for each of the two time periods: 3 months and 8 months. A t

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10

Booster, Maurits Harm. "The Non-Heart Beating donor, a new source of kidneys for transplantation clinical and experimental studies /." Maastricht : Maastricht : Universitaire Pers Maastricht ; University Library, Maastricht University [Host], 1995. http://arno.unimaas.nl/show.cgi?fid=6644.

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11

Persson, Per-Erik. "Heterotopic Ossification : Clinical and Experimental Studies on Risk Factors, Etiology and Inhibition by Non-steroidal Anti-inflammatory Drugs." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3908.

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12

Jungner, Måns. "Healing of endosseous implants with different surface characteristics in grafted and non-grafted bone : clinical and experimental studies." Doctoral thesis, Umeå universitet, Institutionen för odontologi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-85884.

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Aims: This study uses radiological and clinical evaluations of the healing of endosseous titanium implants presented with different surface characteristics in the clinical situation (paper I-III) and experimentally to describe the early bone healing in maxillary sinus membrane elevation with and without the use of grafting material (paper IV). Material and methods: In paper I, 136 patients were treated with 394 dental implants – 199 were oxidized titanium implants (Nobel Biocare TiUnite) and 195 were turned titanium surface implants (Nobel Biocare Mark III). Implant survival rates were retrosp

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13

Ball, David L. "Clinical studies of the effect of radiotherapy dose and fractionation on survival in patients with limited non-small cell lung cancer /." Title page, table of contents and abstract only, 2001. http://web4.library.adelaide.edu.au/theses/09MD/09MDB187.pdf.

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14

Politis, Marios. "Clinical and PET imaging studies in Parkinson's disease motor and non-motor complications : serotonergic and dopamimergic mechanisms and applications in treatment." Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/6137.

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The clinical course of Parkinson’s disease (PD) is complicated by the development of motor and non-motor complications. This thesis, using clinical motor and non-motor assessments and positron emission tomography (PET) imaging with 11C-raclopride, 11CDASB and 18F-DOPA, aims to explore in PD the role of: (1) postsynaptic dopamine D2 receptor dysfunction, (2) serotonergic dysfunction in the development of non-motor symptoms such as depression and body weight change, (3) striatal serotonergic neurons in levodopa- and graft -induced dyskinesias (LIDs and GIDs), and (4) the efficacy of treatment wi

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15

Schädlich, Andreas Verfasser], Karsten [Akademischer Betreuer] [Mäder, Achim [Akademischer Betreuer] Göpferich, and Jörg [Akademischer Betreuer] Kreßler. "Pre‐clinical in vivo studies of parenteral drug delivery systems using non‐invasive multispectral fluorescence imaging : [kumulative Dissertation] / Andreas Schädlich. Betreuer: Karsten Mäder ; Achim Göpferich ; Jörg Kreßler." Halle, Saale : Universitäts- und Landesbibliothek Sachsen-Anhalt, 2013. http://d-nb.info/1045194824/34.

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16

Flenet, Timothé. "Mesure non invasive de suivi des transferts de fluides liés aux activités cardiorespiratoires chez le rat : vers une «bague aortique virtuelle»." Thesis, Université Grenoble Alpes (ComUE), 2017. http://www.theses.fr/2017GREAS013/document.

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Il est avéré que les signaux de pléthysmographie par inductance comportent des composantes cardiaques et respiratoires pouvant présenter un intérêt pour un suivi physiologique. Cette technique est largement utilisée chez l’homme et chez les mammifères de taille moyenne, mais n’a jamais été mise en œuvre chez les petits rongeurs de laboratoire comme le rat. Cette thèse vise à apporter la preuve analytique et expérimentale (TRL3) d’une application cardiaque de la pléthysmographie cardiorespiratoire par inductance (PCRI) fondée sur le concept amont de « bague aortique virtuelle » (BAOV). La BAOV

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17

Nyström, Josefina. "Multivariate non-invasive measurements of skin disorders." Doctoral thesis, Umeå University, Chemistry, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-865.

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<p>The present thesis proposes new methods for obtaining objective and accurate diagnoses in modern healthcare. Non-invasive techniques have been used to examine or diagnose three different medical conditions, namely neuropathy among diabetics, radiotherapy induced erythema (skin redness) among breast cancer patients and diagnoses of cutaneous malignant melanoma. The techniques used were Near-InfraRed spectroscopy (NIR), Multi Frequency Bio Impedance Analysis of whole body (MFBIA-body), Laser Doppler Imaging (LDI) and Digital Colour Photography (DCP).</p><p>The neuropathy for diabetics was stu

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18

Prudon, Nicolas. "Integrative study, from the cell to the animal model, of the development of a cell therapy for Parkinson's disease." Electronic Thesis or Diss., Bordeaux, 2024. http://www.theses.fr/2024BORD0071.

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Un ensemble d'études précliniques soutient désormais le développement de thérapies de remplacement cellulaire dérivées de cellules souches pluripotentes pour soulager les symptômes moteurs chez les patients parkinsoniens. Le remplacement de la principale population cellulaire dysfonctionnelle au sein de la maladie, les neurones dopaminergiques A9, est l'objectif principal de ces thérapies. Pour y parvenir, la plupart des approches thérapeutiques impliquent la greffe de suspensions cellulaires de progéniteurs dopaminergiques. Cependant, une quantité considérable de cellules meurent pendant le p

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19

Hawley, Anna R. "A Longitudinal Analysis of Psychosocial Coping, Religious/Spiritual Appraisals, and Religious/Spiritual Coping in Predicting College Students’ Adjustment to Non-Marital Breakup." Bowling Green State University / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1431551368.

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20

Merandi, Gabrielle. "Transgender and Gender Diverse Students' Accounts of College Life." Bowling Green State University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1470228047.

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21

Robbie, Maxine Ann. "Studies of the mechanisms of resistance of non-cycling cells to amsacrine and related antitumour drugs." Thesis, University of Auckland, 1988. http://hdl.handle.net/2292/3198.

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Several studies have shown that non-cycling cells are resistant to the cytotoxic effects induced by amsacrine (m-AMSA; 4'-(9-acridinylamino)methanesulphon-m-anisidide). This resistance may limit the activity of m-AMSA and related 9-anilinoacridine antitumour agents against solid tumours. The biochemical mechanism(s) for this resistance have been investigated using spontaneously transformed Chinese hamster fibroblast (AA8 cells) in log- and plateau-phase spinner cultures. In early plateau phase most cells entered a growth-arrested state with a G1-G0 DNA content and showed a marked decrease in s

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22

Taponen, S. (Saara). "Metabolic and clinical characteristics of women with self-reported symptoms of polycystic ovary syndrome." Doctoral thesis, University of Oulu, 2004. http://urn.fi/urn:isbn:9514273176.

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Abstract Oligomenorrhea (menstrual disturbances) and hirsutism (excessive growth of body hair) are typical symptoms of polycystic ovary syndrome, a common endocrine disorder with long-term health risks among fertile-age women. Associations between body size development and polycystic ovary syndrome symptoms in a cohort design (528 symptomatic and 1479 asymptomatic women) and endocrine, metabolic and clinical characteristics of women with self-reported symptoms of oligomenorrhea or hirsutism in a nested case-control design (518 cases and 1036 controls) were investigated in this general populat

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23

Gogusetti, Vivek Shashank Nag. "Functions of ATR Kinase in Terminally Differentiated Human Epidermal Keratinocyles and in Human Ex-Vivo Skin After Exposure to Ultraviolet B Radiation." Wright State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=wright1622357540982634.

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24

Kain, Megan Marie. "Bind, Tether, and Transcend: Achieving Integration Through Extra-Therapeutic Dance." Antioch University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1466901499.

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25

Szabó, Zoltán. "Diabetes and coronary surgery : metabolic and clinical studies on diabetic patients after coronary surgery with special reference to cardiac metabolism and high-dose GIK /." Linköping : Univ, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-5219.

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26

Fouchet, Philippe. "Le phénomène épileptique: fonction et statut clinique des manifestations épileptiformes chez des sujets présentant une épilepsie et/ou des troubles pseudo-épileptiques d'origine non organique." Doctoral thesis, Universite Libre de Bruxelles, 2001. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211516.

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27

Nutt, David, Christer Allgulander, Yves Lecrubier, T. Peters, and Hans-Ulrich Wittchen. "Establishing non-inferiority in treatment trials in psychiatry - guidelines from an Expert Consensus Meeting." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-106816.

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Comparing the efficacy of different treatments in psychiatry is difficult for many reasons, even when they are investigated in `head-to-head' studies. A consensus meeting was, therefore, held to produce best practice guidelines for such studies. This article presents the conclusions of this consensus and illustrates it using published data in the field of antidepressant treatment of generalized anxiety disorder.

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Gruntman, Alisha. "A Translational Pathway for Recombinant Adeno-Associated Virus Human Gene Therapy: From Target Identification and Animal Modeling of the Disease to Non-Human Primate and Human Studies." eScholarship@UMMS, 2011. http://escholarship.umassmed.edu/gsbs_diss/882.

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Many steps go into developing a clinical viral gene therapy. The course starts with appropriate disease selection and moves through the many hurdles of in-vitro testing, animal model validation and proof-of-concept studies, all the way through pre-clinical large animal studies. In this thesis, I propose to outline the process of developing a translation pathway for a gene therapy using recombinant adeno-associated virus (rAAV). I will expand on this outline using data that I have generated during the course of my Ph.D. that ranges from animal model validation all the way through pre-clinical v

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Gruntman, Alisha. "A Translational Pathway for Recombinant Adeno-Associated Virus Human Gene Therapy: From Target Identification and Animal Modeling of the Disease to Non-Human Primate and Human Studies." eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/882.

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Many steps go into developing a clinical viral gene therapy. The course starts with appropriate disease selection and moves through the many hurdles of in-vitro testing, animal model validation and proof-of-concept studies, all the way through pre-clinical large animal studies. In this thesis, I propose to outline the process of developing a translation pathway for a gene therapy using recombinant adeno-associated virus (rAAV). I will expand on this outline using data that I have generated during the course of my Ph.D. that ranges from animal model validation all the way through pre-clinical v

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30

Nutt, David, Christer Allgulander, Yves Lecrubier, T. Peters, and Hans-Ulrich Wittchen. "Establishing non-inferiority in treatment trials in psychiatry - guidelines from an Expert Consensus Meeting." Technische Universität Dresden, 2008. https://tud.qucosa.de/id/qucosa%3A26701.

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Comparing the efficacy of different treatments in psychiatry is difficult for many reasons, even when they are investigated in `head-to-head' studies. A consensus meeting was, therefore, held to produce best practice guidelines for such studies. This article presents the conclusions of this consensus and illustrates it using published data in the field of antidepressant treatment of generalized anxiety disorder.

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Zschaeck, Sebastian, Monique Simon, Steffen Löck, et al. "PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial." Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-219714.

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Background Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation pneumonitis limit patients’ quality of life, and the latter can be potentially life-threatening. Due to its distinct physical characteristics, proton therapy enables better sparing of normal tissues, which is supposed to translate into a reduction of radiation-induced side effects. Methods/design This is a single-centre, prospective, randomised controlled, phase II clinical tr

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Zschaeck, Sebastian, Monique Simon, Steffen Löck, et al. "PRONTOX – proton therapy to reduce acute normal tissue toxicity in locally advanced non-small-cell lung carcinomas (NSCLC): study protocol for a randomised controlled trial." BioMed Central, 2016. https://tud.qucosa.de/id/qucosa%3A30184.

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Background Primary radiochemotherapy with photons is the standard treatment for locally advanced-stage non-small cell lung cancer (NSCLC) patients. Acute radiation-induced side effects such as oesophagitis and radiation pneumonitis limit patients’ quality of life, and the latter can be potentially life-threatening. Due to its distinct physical characteristics, proton therapy enables better sparing of normal tissues, which is supposed to translate into a reduction of radiation-induced side effects. Methods/design This is a single-centre, prospective, randomised controlled, phase II clinical tr

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Wang, Lin-Ti, and 王麟弟. "Clinical and laboratory studies of non-alcoholic fatty liver disease in Taiwan." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/80617015563711969961.

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碩士<br>國立臺灣大學<br>臨床醫學研究所<br>93<br>論文英文簡述 Background: Nonalcoholic fatty liver disease (NAFLD) is not an uncommon disease in developed countries. NAFLD is frequently associated with type II DM, obesity, dyslipidemia, but some patients with NAFLD still have normal glucose tolerance or normal body weight. In the literatures, NAFLD may be a common cause of cryptogenic hepatitis or even cirrhosis and the relationship between NAFLD and HFE gene mutations (C282Y and H63D) remains controversial. Adiponectin has antilipogenic effects that may protect nonadipocytes tissues such as liver against lipid ac

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Aldrich, Carrie Lynn. "Clinical and molecular evolutionary studies of the non-classical human leukocyte antigen HLA-G /." 2001. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3006469.

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Foley, Christine Marie. "Comparison And Application Of Methods To Address Confounding By Indication In Non-Randomized Clinical Studies." 2013. https://scholarworks.umass.edu/theses/1121.

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Objective: The project aimed to compare marginal structural models, and propensity score adjusted models with Cox Proportional Hazards models to address confounding by indication due to time-dependent confounders. These methods were applied to data from approximately 120,000 women in the Women’s Health Initiative to evaluate the causal effect of antidepressant medication with respect to diabetes risk. Methods: Four approaches were compared. Three Cox Models were used. The first used baseline covariates. The second used time-varying antidepressant medication use, BMI and presence of elevated de

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(8086361), Yuhao Peng. "Communication Features Associated with Clinical Performance and Non-technical Skills in Healthcare Settings." Thesis, 2019.

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<p>Effective teamwork and communication are critical to patient outcomes, and subjective assessment tools have been developed for measuring team performance using both technical and non-technical skills. However, inherent biases remain with using subjective assessment tools.</p><p>In this study, 3rd-year medical students participated in the Acute Care Trauma Simulation (ACTS). The student performed the role of clinician in a team that included a nurse and a simulated patient. Participants conducted post-operative patient management, patient care diagnoses, and treatment. Audio from all team me

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Serralheiro, Ana Isabel Azevedo. "Intranasal Delivery of Antiepileptic Drugs: Non-clinical Evaluation of Pharmacokinetics and Brain Biodistribution." Doctoral thesis, 2016. http://hdl.handle.net/10316/29482.

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Tese de doutoramento em Ciências Farmacêuticas, na especialidade de Farmacologia e Farmacoterapia, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>Even though remarkable advances in the treatment of epilepsy have been made over the last years, the currently available anticonvulsant pharmacotherapy is unsatisfactory as it provides only the management of epileptic seizures, is not effective in a significant percentage of patients, and is often associated to several adverse effects. Therefore, the development of novel and alternative therapeutic approaches towards a safer and mo

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Yen, Meng Hsiu, and 顏盟修. "Intravenous immunoglobulin and lactoferrin: evaluation of the possible non-specific antiviral measurements for pediatric non-polio enterovirus infections, from clinical to bench studies." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/51938092964146339627.

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博士<br>長庚大學<br>臨床醫學研究所<br>101<br>Non-polio enterovirus infections are common infectious diseases of children worldwide including Taiwan. Although most enterovirus infections are self-limited, the severe infections including meningoencephalitis resulted from EV71 infections and hepatitis with coagulopathy in neonatal patients are potentially fatal and may accompany by sequel. The treatment of severe enterovirus infections is mainly supportive due to the lack of licensed specific anti-viral agent. This underlines the importance of developing or evaluating the potentially effective agents currentl

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Chang, Gee-Chen, and 張基晟. "The Molecular mechanisms of ZD1839 and Gemcitabine on non-small cell lung cancer from clinical to basic studies." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/57086510420698621060.

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博士<br>中山醫學大學<br>醫學分子毒理學研究所<br>93<br>Lung cancer is the leading cause of cancer deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for about 85%, while SCLC accounts for the rest 15%. In spite of new treatments, the overall five-year survival rate remains about 14% and most patients present with advanced disease. Novel therapeutic strategies to improve efficacy in accord with safety are urgently needed. Epithelial growth factor receptor (EGFR) has been proposed as a target for anticancer therapy. ZD1839 (Iressa) is a quinazoline derivative that selectively inhibits the EGFR tyrosine

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Chou, Chung-Wei, and 周中偉. "The studies on immune response of Pneumocystis jirovecii pneumonia and its clinical relevance in non-acquired immunodeficiency syndrome patients." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/53037494974431029362.

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博士<br>國立陽明大學<br>臨床醫學研究所<br>103<br>Pneumocystis jirovecii pneumonia (PJP) is a common and potentially lethal infectious disease in immunocompromised patients with or without acquired immunodeficiency syndrome (AIDS). AIDS and other immunocompromised patients presented two distinct clinical patterns of PJP. Compared with AIDS patients, the PJP in non-AIDS immunocompromised patients shows a more acute and aggressive clinical course, and is associated with higher mortality. Some lines of evidence suggests that the major factor contributing to morbidity and mortality of PJP patients appears to be t

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Gonçalves, Daniela de Oliveira. "Non-clinical Evaluation of the Pharmacokinetics and Pharmacodynamics of Opicapone, a Novel Catechol-O-methyltransferase Inhibitor." Doctoral thesis, 2017. http://hdl.handle.net/10316/79620.

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Tese de doutoramento em Ciências Farmacêuticas, na especialidade de Farmacologia e Farmacoterapia, apresentada à Faculdade de Farmácia da Universidade de Coimbra<br>Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder with an increasing worldwide incidence. Despite the progress in understanding the pathogenesis of the disease and in its therapy over the last years, no treatments are currently available to cure or modify the neurodegenerative process. Therefore, PD treatment remains symptomatic. Curiously, almost 50 years after the clinical introduction of levodopa,

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Ball, David L. (David Lee). "Clinical studies of the effect of radiotherapy dose and fractionation on survival in patients with limited non-small cell lung cancer." 2001. http://web4.library.adelaide.edu.au/theses/09MD/09MDB187.pdf.

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Bibliography: leaves 180-204. A thesis which examines the proposition that higher doses of radiotherapy might be associated with longer survival in patients with non-metastatic non-small cell lung cancer by analysing the survival outcomes for patients treated with a variety of radiotherapy doses according to a standardised policy, and using modern treatment planning and delivery techniques.

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Ball, David Lee. "Clinical studies of the effect of radiotherapy dose and fractionation on survival in patients with limited non-small cell lung cancer / by David L. Ball." Thesis, 2001. http://hdl.handle.net/2440/38238.

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Bibliography: leaves 180-204<br>A thesis which examines the proposition that higher doses of radiotherapy might be associated with longer survival in patients with non-metastatic non-small cell lung cancer by analysing the survival outcomes for patients treated with a variety of radiotherapy doses according to a standardised policy, and using modern treatment planning and delivery techniques.<br>Thesis (M.D.) -- University of Adelaide, Dept. of Medicine, 2001

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Fylan, Beth, Hanif Ismail, S. Hartley, et al. "A non-randomised feasibility study of an intervention to optimise medicines at transitions of care for patients with heart failure." 2021. http://hdl.handle.net/10454/18551.

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Yes<br>Heart failure affects 26 million people globally, and the optimal management of medicines is crucial for patients, particularly when their care is transferred between hospital and the community. Optimising clinical outcomes requires well-calibrated cross-organisational processes with staff and patients responding and adapting to medicines changes. The aim of this study was to assess the feasibility of implementing a complex intervention (the Medicines at Transitions Intervention; MaTI) co-designed by patients and healthcare staff. The purpose of the intervention was to optimise medicine

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Světlík, Svatopluk. "Variabilita farmakokinetiky a možnost jejího sledování." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-415775.

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Backgroun and aims: Pharmacokinetic variability is of paramount importance for sucessfull pharmacotherapy. The main purpose of this work was to study variability of pharmacokinetics in clinical and non-clinical setting with the aim to predict variability in target population. Specifically, three drugs were chosen, sufentanil, with relativelly narrow therapeutic index, and nabumeton and abirateron, both with known high variability. Methods: The study of pharmacokinetic variability of sufentanil was based on clinical samples taken from patients undergoing surgical cardiac procedure, where the su

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Forkel, Walter. "Closed-World Semantics for Query Answering in Temporal Description Logics." 2020. https://tud.qucosa.de/id/qucosa%3A73773.

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Ontology-mediated query answering is a popular paradigm for enriching answers to user queries with background knowledge. For querying the absence of information, however, there exist only few ontology-based approaches. Moreover, these proposals conflate the closed-domain and closed-world assumption, and therefore are not suited to deal with the anonymous objects that are common in ontological reasoning. Many real-world applications, like processing electronic health records (EHRs), also contain a temporal dimension, and require efficient reasoning algorithms. Moreover, since medical data is no

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Mielke, Matthias. "Maximum Likelihood Theory for Retention of Effect Non-Inferiority Trials." Doctoral thesis, 2010. http://hdl.handle.net/11858/00-1735-0000-0006-B3D4-3.

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Kombrink, Karola. "Ein semiparametrisches Verfahren zur Planung und Auswertung von Nichtunterlegenheitsstudien im Cox-Modell." Doctoral thesis, 2011. http://hdl.handle.net/11858/00-1735-0000-0006-B3F6-8.

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VRZALOVÁ, Monika. "Role sestry ve screeningu deprese u seniorů." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-260905.

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The diploma thesis deals with problems of depression in older people. Mainly the work is focused on identifying and analyzing the role of nurses in screening for depression in older people in primary care, acute care, long-term care and home care. This thesis was focused on theoretical direction and was used the method of design and demonstration. In this thesis was set one main goals with five research questions. The main goal was to identify and analyze the role of nurses in screening for depression in the elderly. RQ 1: What is the role of the nurse in screening for depression in the elderl

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