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Journal articles on the topic 'Non-clinical studies'

Author: Grafiati

Published: 25 May 2024

Last updated: 19 July 2025

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1

Sitruk-Ware, R. "Non-clinical studies of progesterone." Climacteric 21, no. 4 (2018): 315–20. http://dx.doi.org/10.1080/13697137.2018.1463982.

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2

Swanson, Steven J., and Jeanine Bussiere. "Immunogenicity assessment in non-clinical studies." Current Opinion in Microbiology 15, no. 3 (2012): 337–47. http://dx.doi.org/10.1016/j.mib.2012.05.015.

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3

Molinier, B., M. Henriquet, N. Fourcine, and B. Remandet. "Functional immunotoxicity assays in non-clinical studies." Toxicology Letters 205 (August 2011): S149. http://dx.doi.org/10.1016/j.toxlet.2011.05.528.

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4

Franco, Raúl, Juan M. Rodriguez, Fernanda Elías, et al. "Non-Clinical Safety Studies of IMT504, a Unique Non-CpG Oligonucleotide." Nucleic Acid Therapeutics 24, no. 4 (2014): 267–82. http://dx.doi.org/10.1089/nat.2013.0479.

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5

Le Tourneau, C., M. Kamal, O. Tredan, et al. "Poster session 7. Clinical Studies - non-phase 1." Annals of Oncology 24, suppl 1 (2013): i36. http://dx.doi.org/10.1093/annonc/mdt049.

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6

Singer, C. R. J., and A. H. Goldstone. "Clinical studies of ABMT in non-Hodgkin's lymphoma." Clinics in Haematology 15, no. 1 (1986): 105–50. http://dx.doi.org/10.1016/s0308-2261(86)80008-x.

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7

AWAZU, Shoji. "ISSUES ABOUT CURRENT “GUIDELINES FOR NON - CLINICAL PHARMACOKINETIC STUDIES”." Drug Metabolism and Pharmacokinetics 11, supplement (1996): 5126–27. http://dx.doi.org/10.2133/dmpk.11.supplement_5126.

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8

AWAZU, Shoji. "Issues about Current "Guidelines for Non-Clinical Pharmacokinetic Studies"." Drug Metabolism and Pharmacokinetics 12, no. 3 (1997): 217–18. http://dx.doi.org/10.2133/dmpk.12.217.

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9

Parnham, Michael J., Janice Schindler-Horvat, and Marija Kozlović. "Non-Clinical Safety Studies on Biosimilar Recombinant Human Erythropoietin." Basic & Clinical Pharmacology & Toxicology 100, no. 2 (2007): 73–83. http://dx.doi.org/10.1111/j.1742-7843.2007.00028.x.

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10

SCHMITT, GERHARD J. "Principles for the conduct of non-drug clinical studies." International Journal of Cosmetic Science 16, no. 1 (1994): 39–43. http://dx.doi.org/10.1111/j.1467-2494.1994.tb00080.x.

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11

Bonomi, Philip. "Clinical studies with non-iressa EGFR tyrosine kinase inhibitors." Lung Cancer 41 (August 2003): 43–48. http://dx.doi.org/10.1016/s0169-5002(03)00141-7.

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12

Makin, Andrew, Christina Skytte, and Nanna Grand. "Use of minipigs in non-clinical juvenile toxicology studies." Toxicology 278, no. 3 (2010): 373–74. http://dx.doi.org/10.1016/j.tox.2010.08.135.

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13

Barton, Bette Lee. "FDA's Inspections of US and Non-US Clinical Studies." Drug Information Journal 24, no. 3 (1990): 463–68. http://dx.doi.org/10.1177/009286159002400303.

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14

Ahrweiler, Michael, Wolfgang Meyer, Daniel Perrissoud, and Axel Zander. "Abstract 7278: Non-clinical toxicity studies of S-CP201." Cancer Research 85, no. 8_Supplement_1 (2025): 7278. https://doi.org/10.1158/1538-7445.am2025-7278.

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Abstract Edelfosine, an anticancer alkylphospholipid, has been widely investigated. Inter alia, it integrates into cell membranes (including mitochondria and ER) and acts via CD95-driven apoptosis, AKT3/PI3K inhibition, phospholipase C and protein kinase C inhibition, and impacts cholesterol metabolism. It exhibits antiangiogenic and antimetastatic effects, selectively targets malignant cells, and has shown efficacy in preclinical xenograft models, (e.g metastatic breast and prostate cancers), and in phase 2 trials across tumor types. The main adverse event was dose-dependent, reversible gastr

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15

Broome, Joseph L. "Main Non-Clinical Factors Influencing Endodontic Referral." Primary Dental Journal 5, no. 3 (2016): 64–69. http://dx.doi.org/10.1177/205016841600500307.

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Specialisation in endodontics allows for endodontic referrals by general dental practitioner (GDPs) and the study of factors influencing referral. These centre on a triad consisting of the referral process, non-clinical and clinical reasons for referral. Many non-clinical factors have been identified which may influence the referral process to the endodontist. A systematic review study was undertaken into the main non-clinical factors influencing endodontic referral by general dental practitioners to endodontists. Such awareness and appreciation of these factors benefits the commercial aspect

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16

Asiamah, Nestor, Henry Kofi Mensah, and Eric Fosu Oteng-Abayie. "Non-Probabilistic Sampling in Quantitative Clinical Research." International Journal of Applied Research on Public Health Management 7, no. 1 (2022): 1–18. http://dx.doi.org/10.4018/ijarphm.290379.

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Quantitative researchers need a probabilistic sample to generalise their findings, but research constraints often compel them to use non-probabilistic samples. The use of non-probability sampling methods in quantitative studies has therefore become a norm. Interestingly, even studies published in top-quality journals compromise best practices that the use of non-probabilistic samples requires. Based on a thorough review of relevant studies, we developed a typology of non-probability sampling methods used in quantitative health studies. An attempt was made to discuss the limit of inference unde

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17

Sasahara, Kunihiro. "Timing of Non-Clinical Safety Studies for Conduct of Clinical Trials -Pharmacokinetic Considerations." Drug Metabolism and Pharmacokinetics 12, supplement (1997): 140. http://dx.doi.org/10.2133/dmpk.12.supplement_140.

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18

Weingand, K. W. "International harmonisation of clinical pathology testing for non-clinical toxicity and safety studies." Comparative Haematology International 3, no. 3 (1993): 164–67. http://dx.doi.org/10.1007/bf00186101.

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19

Sacaan, Aida, Satoko Nonaka Hashida, and Nasir K. Khan. "Non-clinical combination toxicology studies: strategy, examples and future perspective." Journal of Toxicological Sciences 45, no. 7 (2020): 365–71. http://dx.doi.org/10.2131/jts.45.365.

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20

Tim, Richard W., John R. Gilbert, Jeffrey M. Stajich, et al. "Clinical Studies in Non-chromosome 4-Linked Facioscapulohumeral Muscular Dystrophy." Journal of Clinical Neuromuscular Disease 3, no. 1 (2001): 1–7. http://dx.doi.org/10.1097/00131402-200109000-00001.

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21

Stephan-Gueldner, M., H. Buergin, J. Funk, et al. "Opportunities for in vivo imaging in non-clinical safety studies." Toxicology Letters 205 (August 2011): S24. http://dx.doi.org/10.1016/j.toxlet.2011.05.097.

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22

Champeroux, Pascal, Eric Martel, John Sinclair Lawrence Fowler, et al. "Calculation of QT shift in non clinical safety pharmacology studies." Journal of Pharmacological and Toxicological Methods 59, no. 2 (2009): 73–85. http://dx.doi.org/10.1016/j.vascn.2008.11.001.

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23

Champeroux, Pascal, Eric Martel, Anne Maurin, et al. "Calculation of QT shift in non clinical safety pharmacology studies." Journal of Pharmacological and Toxicological Methods 62, no. 2 (2010): e20. http://dx.doi.org/10.1016/j.vascn.2010.11.069.

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24

Matsumoto, Mineo, Shinichi Komatsu, Mayumi Tsuchimoto, et al. "Considerations for non-clinical safety studies of therapeutic peptide vaccines." Regulatory Toxicology and Pharmacology 70, no. 1 (2014): 254–60. http://dx.doi.org/10.1016/j.yrtph.2014.06.029.

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25

Stamatas, G. "Dermal Penetration: Models and Non-Invasive Measurements for Clinical Studies." Toxicology Letters 238, no. 2 (2015): S50. http://dx.doi.org/10.1016/j.toxlet.2015.08.140.

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26

Leighton, John K., Joseph DeGeorge, David Jacobson-Kram, James MacGregor, Donna Mendrick, and Alexandra Worobec. "Pharmacogenomic data submissions to the FDA: non-clinical case studies." Pharmacogenomics 5, no. 5 (2004): 507–11. http://dx.doi.org/10.1517/14622416.5.5.507.

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27

Guangying, Du, Ma Shuzhi, Zhu Xiaoyin, et al. "Non-clinical pharmacology and toxicology studies of bevacizumab biosimilar LY01008." European Journal of Pharmacology 936 (December 2022): 175383. http://dx.doi.org/10.1016/j.ejphar.2022.175383.

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28

Bailly, M., C. Perret, N. Truchot, L. Penard, and E. Drevon-Gaillot. "Retrospective analysis on the tolerability of non-standard used vehicles in non-clinical studies." Toxicology Letters 350 (September 2021): S177. http://dx.doi.org/10.1016/s0378-4274(21)00659-7.

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29

Bulli, Francesco, Gabriele Melli, Claudia Carraresi, Eleonora Stopani, Alberto Pertusa, and Randy O. Frost. "Hoarding Behaviour in an Italian Non-Clinical Sample." Behavioural and Cognitive Psychotherapy 42, no. 3 (2013): 297–311. http://dx.doi.org/10.1017/s1352465812001105.

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Background: Hoarding is associated with significant impairment. Although traditionally considered as a symptom of obsessive-compulsive disorder (OCD), some authors have proposed that pathological hoarding could be considered as a stand alone condition. The prevalence of pathological hoarding behaviour has been shown to be high in some countries, but little is known about the prevalence and correlates of hoarding in the non-clinical population in Italy. Method: We studied the prevalence of self-reported hoarding behaviour using the Italian version of the Saving Inventory-Revised, as well as the

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30

Vas, A., and B. Gulyas. "Clinical and non clinical positron emission tomography (PET) studies on vinpocetine, a neuroprotective drug." Journal of the Neurological Sciences 283, no. 1-2 (2009): 266. http://dx.doi.org/10.1016/j.jns.2009.02.107.

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31

Derakhchan, Katayoun, Zhen Lou, Hong Wang, and Robert Baughman. "Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies." Drugs in Context 12 (February 27, 2023): 1–16. http://dx.doi.org/10.7573/dic.2022-6-1.

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32

IVANOVA, S. N., L. A. GALASHEVSKAYA, and V. O. MARTYNOV. "Clinical manifestations of non-compact left ventricular myocardium." Practical medicine 21, no. 4 (2023): 132–35. http://dx.doi.org/10.32000/2072-1757-2023-4-132-135.

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The purpose — to present the data of a clinical case of non-compact left ventricular myocardium complicated by severe cardiac arrhythmias and heart failure. Material and methods. The diagnosis of non-compact myocardium of the left ventricle became possible since 1990s after the introduction of echocardiography as a diagnostic method. The disease genesis is still unclear, starting with clinical manifestations of complications: cardiac arrhythmia or heart failure or thromboembolism, leading to fatal outcomes. Conclusions. The article is of interest to practitioners, since non-compact myocardium

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33

Vokes, Everett E., and Mark R. Green. "Clinical Studies in Non-small Cell Lung Cancer: The CALGB Experience." Cancer Investigation 16, no. 2 (1998): 72–79. http://dx.doi.org/10.3109/07357909809039760.

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34

Calabrò, Luana, Riccardo Danielli, Luca Sigalotti, and Michele Maio. "Clinical Studies With Anti–CTLA-4 Antibodies in Non-melanoma Indications." Seminars in Oncology 37, no. 5 (2010): 460–67. http://dx.doi.org/10.1053/j.seminoncol.2010.09.006.

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35

Matsumura, Yasuhiro. "Non-clinical models to consider in DDS studies of cancer treatments." Drug Delivery System 39, no. 3 (2024): 152. http://dx.doi.org/10.2745/dds.39.152.

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36

Hammond, D. W., B. W. Hancock, and M. H. Goyns. "Clinical implications of molecular and cytogenetic studies of non-Hodgkin's lymphomas." Cancer Treatment Reviews 24, no. 2 (1998): 157–63. http://dx.doi.org/10.1016/s0305-7372(98)90080-9.

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37

Hardy, Russell, and Sandra J. Horning. "Molecular Biologic Studies in the Clinical Evaluation of Non-Hodgkin’s Lymphoma." Hematology/Oncology Clinics of North America 5, no. 5 (1991): 891–900. http://dx.doi.org/10.1016/s0889-8588(18)30391-5.

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38

Smith, James D., Padmakumar Narayanan, and Nianyu Li. "Biomarkers of platelet dysfunction in non-clinical safety studies and humans." Current Opinion in Toxicology 17 (October 2019): 41–49. http://dx.doi.org/10.1016/j.cotox.2019.11.001.

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39

KAWAURA, Mitsuhiro, Yukio INUYAMA, Masao TOJI, et al. "Clinical Studies on Non-epithelial Malignant Tumors of Head and Neck." Japanese jornal of Head and Neck Cancer 15, no. 2 (1989): 42–47. http://dx.doi.org/10.5981/jjhnc1974.15.2_42.

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40

Picardi, Angelo, Mauro Pallagrosi, Laura Fonzi, et al. "Attachment in Patients with Bipolar and Unipolar Depression: A Comparison with Clinical and Non-clinical Controls." Clinical Practice & Epidemiology in Mental Health 15, no. 1 (2019): 143–52. http://dx.doi.org/10.2174/1745017901915010143.

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Background: A link between depression and insecure attachment has long been postulated. Although many studies examined the relationship between depressive symptoms and attachment, relatively few studies were performed on patients diagnosed with depression. Also, research on patients with bipolar disorder is scarce. Objective: We aimed at testing the association between attachment insecurity and unipolar and bipolar depression. Methods: We studied 21 patients with bipolar disorder, current episode depressed, and three age- and sex-matched groups, each consisting of 21 individuals: patients with

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41

Parker, G., G. Tavella, T. Ricciardi, and D. Hadzi‐Pavlovic. "Differentiating clinical and non‐clinical depression: a heuristic study offering a template for extension studies." Acta Psychiatrica Scandinavica 141, no. 4 (2019): 340–49. http://dx.doi.org/10.1111/acps.13130.

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42

Murazov, Ia G., M. A. Kovaleva, M. N. Makarova, and V. G. Makarov. "Introduction of multicenter design in the non-clinical phase to overcome translational barriers in clinical trials." Translational Medicine 10, no. 1 (2023): 52–63. http://dx.doi.org/10.18705/2311-4495-2023-10-1-52-63.

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Background. The translating of individual preclinical studies (PCTs) results into clinical practice is accompanied by a significant number of failures and is associated with significant time and financial costs. The unsatisfactory design of individual non-clinical studies and the reports submitted after having done in vivo experiments at one laboratories do not allow overcoming translational barriers and increasing the results reproducibility. To conduct multicenter non-clinical trials is relevant to to confirm the effectiveness of medicines and increase the chances of successful translation o

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43

Ebbehoj, Andreas, Mette Østergaard Thunbo, Ole Emil Andersen, Michala Vilstrup Glindtvad, and Adam Hulman. "Transfer learning for non-image data in clinical research: A scoping review." PLOS Digital Health 1, no. 2 (2022): e0000014. http://dx.doi.org/10.1371/journal.pdig.0000014.

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Background Transfer learning is a form of machine learning where a pre-trained model trained on a specific task is reused as a starting point and tailored to another task in a different dataset. While transfer learning has garnered considerable attention in medical image analysis, its use for clinical non-image data is not well studied. Therefore, the objective of this scoping review was to explore the use of transfer learning for non-image data in the clinical literature. Methods and findings We systematically searched medical databases (PubMed, EMBASE, CINAHL) for peer-reviewed clinical stud

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44

Nosé, Michela, Corrado Barbui, Richard Gray, and Michele Tansella. "Clinical interventions for treatment non-adherence in psychosis: Meta-analysis." British Journal of Psychiatry 183, no. 3 (2003): 197–206. http://dx.doi.org/10.1192/bjp.183.3.197.

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BackgroundStudies investigating the efficacy of clinical interventions for reducing treatment non-adherence have generated contrasting findings, and treatment non-adherence remains common in clinical practice.AimsTo systematically review whether there are effective clinical interventions that community psychiatric services can implement to reduce non-adherence.MethodSystematic review and metaregression analysis of randomised controlled trials (RCTs) and controlled clinical trials (CCTs) were used to assess the efficacy of interventions to enhance adherence.ResultsWe reviewed 24 studies, more t

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45

Sharma, Deepa, Laurentius Oscar Osapoetra, and Gregory J. Czarnota. "Implementation of Non-Invasive Quantitative Ultrasound in Clinical Cancer Imaging." Cancers 14, no. 24 (2022): 6217. http://dx.doi.org/10.3390/cancers14246217.

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Quantitative ultrasound (QUS) is a non-invasive novel technique that allows treatment response monitoring. Studies have shown that QUS backscatter variables strongly correlate with changes observed microscopically. Increases in cell death result in significant alterations in ultrasound backscatter parameters. In particular, the parameters related to scatterer size and scatterer concentration tend to increase in relation to cell death. The use of QUS in monitoring tumor response has been discussed in several preclinical and clinical studies. Most of the preclinical studies have utilized QUS for

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46

Aquino, Débora Nascimento de, and Margareth de Fátima Formiga Melo Diniz. "Cannabis toxicological non clinical assays: a literature review." OBSERVATÓRIO DE LA ECONOMÍA LATINOAMERICANA 23, no. 5 (2025): e10033. https://doi.org/10.55905/oelv23n5-138.

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Cannabis sativa L. is one of the most historically significant plants ever documented. Advances in scientific research have substantially enhanced the understanding of its pharmacological properties following the isolation and synthesis of its primary phytocannabinoids, ∆9-tetrahydrocannabinol (∆9-THC) and cannabidiol (CBD) revealing that Cannabis has gained increasing attention for its therapeutic effects. As public awareness of medicinal cannabis expanded, so did the need to assess the toxicity profiles of its bioactive compounds. Establishing safe concentration thresholds is critical to ens

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47

Nekhaeva, T. L., A. A. Kamaletdinova, M. F. Lutfullin, and T. V. Tabanskaya. "Current approaches to quality assessment, non-clinical and clinical studies of dendritic cell vaccines in oncology." Biological Products. Prevention, Diagnosis, Treatment 23, no. 2 (2023): 148–61. http://dx.doi.org/10.30895/2221-996x-2023-23-2-148-161.

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At present, personalised cellular immunotherapy is considered a promising approach to the treatment of malignant neoplasms. The effectiveness of these cellular immunotherapy methods is evaluated in the context of clinical and biological tumour characteristics and the state of the immune system of a particular patient. One of the immunotherapy options for cancer is the development of autologous dendritic cell vaccines.The aim of this study was to analyse current methodological approaches to the evaluation of the quality, efficacy, and safety of dendritic cell cancer vaccines.This review describ

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48

Onishi, Akemi, Akifumi Kogame, Yoshihiko Tagawa, Takahiro Kondo, and Satoru Asahi. "Evaluation of low background liquid scintillation counter for non-clinical ADME studies." Xenobiotica 43, no. 6 (2012): 520–26. http://dx.doi.org/10.3109/00498254.2012.744861.

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49

CHEN, Conrad H. "Non-Clinical Studies of Botanical Medicines as New Drugs-U.S. Regulatory Perspectives." Kampo Medicine 56, no. 2 (2005): 221–30. http://dx.doi.org/10.3937/kampomed.56.221.

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50

Adamo, Maria, Louise Pouliot, Stephanie Barbeau, et al. "Assessing postnatal skeletal development in non-clinical reproductive toxicology and pediatric studies." Reproductive Toxicology 30, no. 2 (2010): 233. http://dx.doi.org/10.1016/j.reprotox.2010.05.047.

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