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Dissertations / Theses on the topic 'Non-coding RNA'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Wong, king-fung, and 黃景峰. "Non-coding RNA identification along genome." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2011. http://hub.hku.hk/bib/B4581949X.

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2

Böhm, Stefanie. "Non-protein-coding RNA : Transcription and regulation of ribosomal RNA." Doctoral thesis, Stockholms universitet, Institutionen för molekylär biovetenskap, Wenner-Grens institut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-102718.

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Cell growth and proliferation are processes in the cell that must be tightly regulated. Transcription of ribosomal RNA and ribosomal biogenesis are directly linked to cell growth and proliferation, since the ribosomal RNA encodes for the majority of transcription in a cell and ribosomal biogenesis influences directly the number of proteins that are synthesized. In the work presented in this thesis, we have investigated the ribosomal RNA genes, namely the ribosomal DNA genes and the 5S rRNA genes, and their transcriptional regulation. One protein complex that is involved in RNA polymerase I and

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3

Fassan, Matteo. "Non-coding RNA dysregulation in Barrett's carcinogenesis." Doctoral thesis, Università degli studi di Padova, 2014. http://hdl.handle.net/11577/3423476.

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While the phenotypic changes involved in the Barrett’s esophageal oncogenic "cascade" are now well established, the molecular profiling of this pathway remains defective. The understanding of the molecular dysregulations underlying the development and progression of cancer has recently been expanded by the characterization of new classes of noncoding RNA gene products, such as the microRNAs (or miRNAs) and the transcribed utraconserved regions (T-UCR). MiRNAs are "endogenous silencers" targeting a large number of genes, and working as tumor suppressors or tumor promoters depending on the ac

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4

Piccinelli, Paul. "Computational identification of non-coding RNAs /." Göteborg : Institute of Biomedicine at Sahlgrenska Academy, Göteborg University, 2006. http://hdl.handle.net/2077/886.

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5

Ottway, Charlotte Jane. "Characterisation of Nespas, a non-coding imprinted RNA." Thesis, University of Oxford, 2010. http://ora.ox.ac.uk/objects/uuid:b159c1e9-8d49-460c-a808-d920e8e17779.

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Nespas is the non-coding antisense transcript of the imprinted Gnas cluster; it is expressed from the paternal allele and is located on mouse distal chromosome 2. In this thesis new transcripts of >10 kb and 0.8 kb have been identified. The 0.8 kb transcript is a spliced variant that is retained in the nucleus and its 3’ end lies approximately 30 kb from the start site. Transcription from the Nespas promoter does not proceed beyond this point. A collection of previously known splice variants have also been detected and are exported to the cytoplasm. Nespas is expressed in the embryo during the

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6

Broseghini, Elisabetta <1993&gt. "Role of non-coding RNA alterations in melanoma." Doctoral thesis, Alma Mater Studiorum - Università di Bologna, 2022. http://amsdottorato.unibo.it/10306/1/Tesi%20finale_Broseghini%20Elisabetta.pdf.

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Cutaneous melanoma (CM) is a potentially lethal form of skin cancer and its most important histopathologic factor for staging is Breslow thickness (BT). Its correct determination is fundamental for pathologists. A deeper understanding of the molecular processes guiding CM pathogenesis could improve diagnosis, treatment and prognosis. MicroRNAs (miRNAs) play a key role in CM biology. The firs aim was to investigate miRNA expression in reference to BT assessment. We found that the combined miRNA expression of miR-21-5p and miR-146a-5p above or below 1.5 was significantly associated with overal

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7

Witham, James. "The role of non-coding RNA in nucleosome remodelling." Thesis, University of Leeds, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.530813.

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8

Lind, Liza. "Non-coding RNA in T cell activation and function." Thesis, Linköpings universitet, Institutionen för klinisk och experimentell medicin, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96966.

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For a long time research has focused on the protein-coding mRNA, but there is a complex world of non-coding RNAs regulating the human body that we yet know very little about. Non-coding RNAs (ncRNAs) are involved in modulation of different cell processes including proliferation, differentiation and apoptosis. In the current study the role of ncRNAs in T cell activation and function was investigated. T cells are important mediators of immune responses, for example upon viral infections. The T helper cells (TH or CD4+ cells) are involved in orchestrating immune processes like aiding the activati

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9

Ozes, Ali Rayet. "Targeting the long non coding RNA HOTAIR in cancer." Thesis, Indiana University, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10154781.

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<p> Ovarian cancer (OC) takes the lives of nearly 14,000 US women every year. Although platinum is one of the most effective drugs in treating ovarian cancer, the development of platinum resistance is one of the biggest challenges facing patients. I have shown that the long non-coding RNA HOTAIR contributes to platinum-resistant OC and determined the regulators and targets of HOTAIR during the platinum-induced DNA damage response. My published data supports the role of HOTAIR in contributing to DNA damage induced cellular senescence and secretion of pro-inflammatory cytokines leading to cispla

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10

Ard, Ryan Anthony. "Functional long non-coding RNA transcription in Schizosaccharomyces pombe." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20396.

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Eukaryotic genomes are pervasively transcribed and frequently generate long noncoding RNAs (lncRNAs). However, most lncRNAs remain uncharacterized. In this work, a set of positionally conserved intergenic lncRNAs in the fission yeast Schizosaccharomyces pombe genome are selected for further analysis. Deleting one of these lncRNA genes (ncRNA.1343) exhibited a clear phenotype: increased drug sensitivity. Further analyses revealed that deleting ncRNA.1343 also disrupted a previously unannotated lncRNA, termed nc-tgp1, transcribed in the opposite orientation of the predicted ncRNA.1343 gene and i

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11

Wright, Jordan. "Capsule Thermoregulation and Non-Coding RNA in Streptococcus pyogenes." OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1505.

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Streptococcus pyogenes is a re-emerging pathogen that produces superficial and life threatening invasive diseases. One important virulence factor in S. pyogenes is hyaluronic acid capsule which has been shown to increase expression at sub-body temperatures in certain strains. This study showed that thermoregulation is common in invasive clinical isolates. Regulation was shown to occur independent of the CovRS two-component regulator in a post transcription manner and before protein level regulation. The endoribonuclease, CvfA, was also confirmed to be required for capsule thermoregulation.

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12

O'Gorman, William Evert. "Analysis of cyclin H interaction with non-coding RNAs." Thesis, University of Oxford, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670092.

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13

Woolford, Julie Ruth. "Statistical analysis of small RNA high-throughput sequencing data." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610375.

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14

Braker, Paul. "ABCB5 and the regulation of p16INK4a by non-coding RNA." Thesis, Queen Mary, University of London, 2014. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7930.

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p16INK4a (p16) traps the cell at the restriction point of the cell cycle by binding to cyclin-dependent kinase 4/6 thus preventing the phosphorylation of the retinoblastoma protein (pRB). As p16 accumulates the cell stops dividing and becomes senescent. This study investigates the modulation of p16 function by the putative membrane protein ABCB5 and a group of five putative oncogenic microRNAs (oncomiRs). ABCB5 is a poorly characterised member of the B-subfamily of human ATP Binding Cassette transporters. ABCB5 is reportedly transcribed into four transcripts, one of which could potentially enc

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15

Heath, Catherine. "The localisation of non-coding RNA in the human cell." Thesis, University of Sheffield, 2018. http://etheses.whiterose.ac.uk/22498/.

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16

Wijesinghe, Susanne. "Role of long non-coding RNA CCDC26 in gene regulation." Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8441/.

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LncRNAs are increasingly being recognised as functionally important for regulation of biological processes. We have identified an lncRNA which we believe is integral in lineage commitment during haematopoiesis. Here, we report that CCDC26 lncRNA is a regulator of β-globin and c-MYC gene expression. Indeed, CCDC26 silencing in erythroleukemic K562 cells led to several gene expression changes. Upon further investigation of genes linked to erythropoiesis, we observed the upregulation of β-globin expression. Our results suggest that CCDC26 regulates expression of β-globin and other genes by modula

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17

BUEMI, VALENTINA. "Telomerase regulation by non-coding RNAs." Doctoral thesis, Università degli Studi di Trieste, 2017. http://hdl.handle.net/11368/2912144.

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I telomeri sono le regioni terminali dei cromosomi ed hanno il ruolo fondamentale di proteggere l’estremità del cromosoma stesso. Per ragioni intrinseche al suo meccanismo di duplicazione, il DNA telomerico non viene completamente replicato, provocando un accorciamento delle estremità cromosomiche ad ogni ciclo di replicazione, che causa un blocco della proliferazione cellulare noto come senescenza. Per controbilanciare questo fenomeno, le cellule tumorali possono riattivare la telomerasi, un enzima che sintetizza nuove ripetizioni telomeriche, o attivare meccanismi alternativi che si basano s

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18

Bussotti, Giovanni 1983. "Detecting and comparing non-coding RNAs." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/128970.

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In recent years there has been a growing interest in the field of non-coding RNA. This surge is a direct consequence of the discovery of a huge number of new non-coding genes, and of the finding that many of these transcripts are involved in key cellular functions. In this context, accurately detecting and comparing RNA sequences becomes extremely important. Aligning nucleotide sequences is one of the main requisite when searching for homologous genes. Accurate alignments reveal evolutionary relationships, conserved regions and more generally, any biologically relevant pattern. Comparing RNA m

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19

Kajitani, Takuiya. "Ser7 of RNAPII-CTD facilitates heterochromatin formation by linking ncRNA to RNAi." Kyoto University, 2018. http://hdl.handle.net/2433/232146.

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20

PALATINI, Jeffrej. "USE OF NEXT-GENERATION SEQUENCING TO STUDY CODING AND NON-CODING RNA IN COLORECTAL CANCER." Doctoral thesis, Università degli studi di Ferrara, 2014. http://hdl.handle.net/11392/2389043.

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The identification of novel mRNA and small RNA signatures of prognostic and diagnostic value in colorectal cancer (CRC) is primary focus of the thesis. The overall aim of the body this work is a deeper understanding of the molecular causes in the pathology of CRC and the identification of biomarkers, specifically mRNAs and other small non-coding RNAs with prognostic values in the clinical setting. These findings would in turn lead to an optimization of the therapeutic targets and ultimately to better clinical management of patients diagnosed with CRC. Next-generation sequencing (NGS) is based

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21

Keniry, Andrew James. "H19 and miR-675 : a long noncoding RNA conceals a growth suppressing microRNA." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609990.

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22

Diffendall, Gretchen. "Deciphering the role of an RNA Pol III-transcribed non-coding RNA in Plasmodium falciparum." Electronic Thesis or Diss., Sorbonne université, 2022. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2022SORUS443.pdf.

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Le parasite protozoaire Plasmodium falciparum est l'agent causal de la forme la plus mortelle de paludisme humain. Ce pathogène utilise l'expression monoallélique de molécules d'adhésion de surface variantes, codées par la famille de gènes var, pour échapper au système immunitaire de l'hôte et provoquer une pathogenèse. On ne sait toujours pas comment l'activation du gène var fonctionne au niveau moléculaire et si des facteurs environnementaux peuvent moduler l'expression du gène var. Notre laboratoire a montré qu'une famille de gènes d'ARN non codants transcrits par Pol III, appelée RUF6, agi

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23

Bartonicek, Nenad. "Computational studies on the biogenesis and function of small non-coding RNAs." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607984.

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24

Lin, Sau-wah Selma. "A study of microRNA-132 and -212 in murine granulosa cells during folliculogenesis." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B43909851.

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25

Mimouni, Naila K. "An investigation of selection constraints on non-coding RNAs and reliability of alignments." Thesis, University of Oxford, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670073.

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26

Tsang, Ho-ching Felice, and 曾可澄. "The emerging roles of non-coding RNAs in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/206474.

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Hepatocellular carcinoma (HCC) is one of the most common and lethal cancers worldwide. The development and progression of HCC is a multistep process which attributed to the accumulation of genetic alterations. Recently, mounting evidence has suggested the role of non-coding RNAs (ncRNAs) as the master driver of carcinogenesis, through their regulation on different oncogenes and tumor suppressive genes. Deregulation of ncRNAs was frequently observed in multiple types of cancers, including HCC. Herein, we demonstrated the aberrant expression pattern of miRNAs and lncRNAs in human HCC and investi

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27

Pallarès, Albanell Joan 1988. "Evaluation of non-coding RNAs in Parkinson's disease." Doctoral thesis, Universitat Pompeu Fabra, 2017. http://hdl.handle.net/10803/664379.

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Parkinson’s disease (PD) is the commonest movement disorder and a devastating neurodegenerative condition. Although PD motor symptoms arise from the progressive loss of dopaminergic neurons on the Substantia Nigra, this disease also affects other brain areas. This thesis explores the intersection between deregulated non-coding RNAs (ncRNAs), key gene expression regulators, and PD. We do so investigating different ncRNAs species: small non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs). Our results suggest that ncRNA deregulation is a specific process, presenting selective temporal an

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28

Cabili, Nataly Moran. "Integrative Characterization of Human Long Non-Coding RNAs." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11409.

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Since its early discovery as a messenger, RNA has been shown to play a diverse set of regulatory, structural and even catalytic roles. The more recent understanding that the genome is pervasively transcribed stimulated the discovery of a new prevalent class of long non coding RNAs (lncRNAs). While these are lower abundant and relatively less conserved than other class of functional RNAs, lncRNAs are emerging as key players in different cellular processes in development and disease.

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29

Zhang, Shaojie. "Computational methods for genome-wide non-coding RNA discovery and analysis." Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 2007. http://wwwlib.umi.com/cr/ucsd/fullcit?p3271244.

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Thesis (Ph. D.)--University of California, San Diego, 2007.<br>Title from first page of PDF file (viewed August 13, 2007). Available via ProQuest Digital Dissertations. Vita. Includes bibliographical references (p. 98-108).

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30

Hammel, Alexander John. "Evolutionary conservation of long intergenic non-coding RNA genes in Arabidopsis." Thesis, University of British Columbia, 2013. http://hdl.handle.net/2429/44974.

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31

Sample, Klarke Michael. "The identification of non-protein coding RNA in the tumour vasculature." Thesis, University of Birmingham, 2016. http://etheses.bham.ac.uk//id/eprint/6696/.

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In the last 15 years a number of studies have sought to identify markers of tumour endothelium. However, studies have yet to identify non-protein markers of the tumour vasculature. This thesis provides novel contributions in this area by using RNA sequencing (RNAseq) to probe the transcriptome of tumour endothelial cells (TEC) and healthy tissue associated endothelial cells (HEC). The ensuing bioinformatic analysis revealed many differentially expressed short nuclear RNA (snoRNA) and long intergenic ncRNA (lincRNA) molecules. Some of which were confirmed as being specifically expressed in (and

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32

Evans, C. M. "Non-coding RNA and transcriptional regulation in CD4 T cell lineages." Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1466165/.

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CD4 T cell lineage choice epitomises the ability of the immune system to become tailored to a specific threat and provides a framework for understanding the mechanisms behind cell specification. The differentiation of T effectors from naïve cells gives rise to pro-inflammatory lineages including T helper 1 (Th1) and Th2 and anti-inflammatory regulatory T cells (Treg). An additional lineage of Treg also exits the thymus in parallel to naïve T cells and together these Treg are required for prevention of autoimmunity. These T cell lineages are distinct in terms of their cytokine production and fu

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33

Chen, Chunlong. "Non-coding RNA genes in eukaryotes genomes : computational identification and evolution." Paris 11, 2007. http://www.theses.fr/2007PA112279.

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Parmi les surprises nées de la confrontation des données génomiques et expérimentales figure l’identification de nombreux gènes d’ARN non-codant (ARNnc). Les ARNnc participent à de nombreux processus fondamentaux comme la régulation de l’expression des gènes (transcription, stabilité des ARN messagers) et la régulation de la synthèse protéique. Cependant, les gènes d’ARNnc restent rarement annotés dans les génome en raison de la faible conservation de leur séquences : la fonction des ARNnc repose essentiellement sur leurs structures. Dans un premier temps, j'ai travaillé à l’identification bio

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34

Weinberg, Zasha. "Accurate annotation of non-coding RNAs in practical time /." Thesis, Connect to this title online; UW restricted, 2005. http://hdl.handle.net/1773/6893.

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35

Isaksson, Åsa. "Characterization of non-coding mRNA in Epstein-Barr virus /." Göteborg : Institute of Biomedicine, Department of Clinical Chemistry and Transfusion Medicine, Göteborg University, 2007. http://hdl.handle.net/2077/4444.

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36

Hezaveh, Kebria [Verfasser]. "Non-coding RNA expression profiling of B-cell malignant (non-Hodgkin) lymphomas / Kebria Hezaveh." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1088402070/34.

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37

Larsson, Pontus. "Computational Approaches to the Identification and Characterization of Non-Coding RNA Genes." Doctoral thesis, Uppsala universitet, Institutionen för cell- och molekylärbiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-9518.

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Non-coding RNAs (ncRNAs) have emerged as highly diverse and powerful key players in the cell, the range of capabilities spanning from catalyzing essential processes in all living organisms, e.g. protein synthesis, to being highly specific regulators of gene expression. To fully understand the functional significance of ncRNAs, it is of critical importance to identify and characterize the repertoire of ncRNAs in the cell. Practically every genome-wide screen to identify ncRNAs has revealed large numbers of expressed ncRNAs and often identified species-specific ncRNA families of unknown function

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38

Broadbent, Kate Mariel. "The regulatory capacity of long non-coding RNA in Plasmodium falciparum malaria." Thesis, Harvard University, 2014. http://nrs.harvard.edu/urn-3:HUL.InstRepos:13065005.

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The mechanisms underpinning gene regulation in P. falciparum malaria remain largely elusive, though mounting evidence suggests a major role for epigenetic feedback. Interestingly, long non-(protein)-coding RNAs (lncRNAs) have been found to play a dominant role in initiating and guiding the transcriptional, epigenetic, and post-transcriptional status of specific loci across a broad range of organisms. LncRNAs are uniquely poised to act co-transcriptionally on neighboring loci, and/or to remain physically tethered at their site of origin, and through sequence-specific binding activities can impa

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39

Ballantyne, Margaret. "Understanding the role of long non-coding RNA (LncRNA) in vascular pathology." Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8101/.

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Coronary heart disease is a major cause of morbidity and mortality in the Western society. In the case of severe atherosclerosis, percutaneous intervention and coronary bypass grafting remain the preferred form of surgical treatment. However, the patency of both these treatments is limited and several bypass grafts and stents fail due to neointimal formation and in stent restenosis attributable to the proliferation of VSMCs. The resultant luminal renarrowing may manifest clinically with the return of symptoms such as chest pain or shortness of breath and ultimately requires further surgical in

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40

Hinas, Andrea. "Developmentally regulated non-coding RNAs in the social amoeba Dictyostelium discoideum /." Uppsala : Dept. of Molecular Biology, Swedish University of Agricultural Sciences, 2007. http://epsilon.slu.se/200708.pdf.

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41

Kowalski, Magdalena Pauline. "Investigating the function of non-coding RNAs in chromosomal DNA replication." Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708507.

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Lin, Sau-wah Selma, and 林秀華. "A study of microRNA-132 and -212 in murine granulosa cells during folliculogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B43909851.

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43

Liu, Xuan, and 刘璇. "Workflows for identifying differentially expressed small RNAs and detection of low copy repeats in human." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2014. http://hdl.handle.net/10722/208038.

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With the rapid development of next-generation sequencing NGS technology, we are able to investigate various aspects biological problems, including genome and transcriptome sequencing, genomic structural variation and the mechanism of regulatory small RNAs, etc. An enormous number of associated computational methods have been proposed to study the biological problems using NGS reads, at a low cost of expense and time. Regulatory small RNAs and genomic structure variations are two main problems that we have studied. In the area of regulatory small RNA, various computational tools have been desi

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44

Paschoal, Alexandre Rossi. "Bioinformática aplicada em RNomics: estratégias computacionais para caracterização de RNAs não-codificadores." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/95/95131/tde-24092013-211625/.

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A visao sobre o dogma central da biologia molecular passou por aperfeicoamentos na virada deste seculo. Muito se deve ao interesse por pesquisas feitas para compreensao do que ate entao eram regioes do genoma conhecidas como DNA Lixo. Neste contexto, projetos de transcriptoma, avancos em tecnologias de sequenciamento, bem como analises em bioinformatica, contribuiram para elucidar o que estava sendo transcrito. Tais regioes foram denominadas como RNAs nao-codificadores ou non-coding RNA (ncRNA) que eram transcritas, mas nao traduzidas em proteinas. Apesar da quantidade de metodos para o estudo

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45

MOROTTI, ANNAMARIA. "INSIGHTS INTO THE NON-CODING GENOME OF PARATHYROID TUMORS." Doctoral thesis, Università degli Studi di Milano, 2019. http://hdl.handle.net/2434/610124.

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Recently, long non-coding RNAs (lncRNAs) have been implicated in the regulation of several physiological processes such as cell growth, differentiation and proliferation. Although lncRNAs functions in human diseases have not been completely disclosed, some lncRNAs have already been identified as prognostic and diagnostic biomarkers in different tumors. LncRNAs have also a crucial role in normal development of endocrine organs and their role in endocrine cancer pathogenesis is emerging. Parathyroid tumors are rare and heterogeneous diseases characterized by genetic and epigenetic alterations

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Choudhury, Nila Roy. "Functional analysis of the non-coding RNAs of murine gammaherpesvirus 68." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4822.

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Murine gammaherpesvirus 68 (MHV-68) is used as a model for the study of gammaherpesvirus infection and pathogenesis. In the left region of the genome MHV-68 encodes four unique genes, eight viral tRNA-like molecules (vtRNAs) and nine miRNAs. The vtRNAs have a predicted cloverleaf-like secondary structure like cellular tRNAs and are processed into mature tRNAs with the addition of 3’ CCA termini, but are not aminoacylated. Their function is unknown; however they have been found to be expressed at high levels during both lytic and latent infection and are packaged in the virion. The miRNAs are e

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Tran, Thao Thanh Thi. "Genomic data mining for the computational prediction of small non-coding RNA genes." Diss., Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/33966.

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The objective of this research is to develop a novel computational prediction algorithm for non-coding RNA (ncRNA) genes using features computable for any genomic sequence without the need for comparative analysis. Existing comparative-based methods require the knowledge of closely related organisms in order to search for sequence and structural similarities. This approach imposes constraints on the type of ncRNAs, the organism, and the regions where the ncRNAs can be found. We have developed a novel approach for ncRNA gene prediction without the limitations of current comparative-based meth

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48

Deng, Lin. "The role of non-coding RNA in the development of pulmonary arterial hypertension." Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7828/.

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Pulmonary arterial hypertension (PAH) is a progressive disease of the small pulmonary arteries, characterised by pulmonary vascular remodelling due to excessive proliferation and resistance to apoptosis of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs). The increased pulmonary vascular resistance and elevated pulmonary artery pressures result in right heart failure and premature death. Germline mutations of the bone morphogenetic protein receptor-2 (bmpr2) gene, a receptor of the transforming growth factor beta (TGF-β) superfamily, account for appr

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49

Harris, Andreas William Kisling. "The design of gene regulatory networks with feedback and small non-coding RNA." Thesis, University of Oxford, 2017. https://ora.ox.ac.uk/objects/uuid:e3a323b1-9067-415d-8728-6c70c1b6cf23.

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The objective of the field of Synthetic Biology is to implement novel functionalities in a biological context or redesign existing biological systems. To achieve this, it employs tried and tested engineering principles, such as standardisation and the design-build-test cycle. A crucial part of this process is the convergence of modelling and experiment. The aim of this thesis is to improve the design principles employed by Synthetic Biology in the context of Gene Regulatory Networks (GRNs). Small Ribonucleic Acids (sRNAs), in particular, are focussed on as a mechanism for post-transcriptional

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NESREEN, HAMAD ABDELGAWWAD HAMAD. "Structural analysis of the interaction between FUS/TLS protein and non-coding RNA." Kyoto University, 2020. http://hdl.handle.net/2433/259065.

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