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Academic literature on the topic 'Non-Effervescent Systems'
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Journal articles on the topic "Non-Effervescent Systems"
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Ayalasomayajula, Lakshmi Usha, Karumoju Navya, Radha Rani Earle, and Andra A. S. E. Pravallika. "Review on non effervescent gastro retentive drug delivery systems-microballons." Asian Journal of Pharmaceutical Research 10, no. 4 (2020): 312–18. http://dx.doi.org/10.5958/2231-5691.2020.00053.2.
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Rajesh Asija, Babulal Choudhary, and Anil Kumar Goyal. "Floating Drug Delivery System- A Review." Tropical Journal of Pharmaceutical and Life Sciences 10, no. 6 (2023): 96–100. https://doi.org/10.61280/tjpls.v10i6.152.
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Floating drug delivery system (FDDS) helps to improve the buoyancy property of the drug over the gastric fluids and hence maintain the longer duration of action. It is helpful in minimizing the dosing frequency. The density of dosage form must be less than the density of gastric contents (1.004 gm/ml) in FDDS. It may effervescent or non-effervescent system. The drugs having narrow absorption window in GIT is good candidate for the floating drug delivery system. The main objective of writing this review article is to compile the recent literature with special focus on classification, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail.
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Shraddha, Mali* Jaya Kamble Dr. Nilesh Chougule. "Impurity Profiling Of API." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1165–71. https://doi.org/10.5281/zenodo.14211554.
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This review was written with the intention of gathering the most recent research on floating drug delivery systems (FDDS), with a particular emphasis on the many kinds of FDDS, their principles, and the mechanism of floating to achieve gastric retention. Systems for delivering drugs that float instantly when they come into touch with the stomach With absorption windows in the upper small intestine, fluids offer intriguing strategies for boosting the bioavailability of medications. The most recent developments in FDDS, such as the formulation and physiological aspects that affect stomach retention and techniques for creating single-unit and multiple-unit floating systems, are covered in detail.The goal of the floating drug delivery system (FDDS) is to prolong the period of stomach stay in order to improve bioavailability and therapeutic efficacy.FDDS releases the drug gradually and regulatedly by allowing the dosage form to float over stomach contents with the use of effervescent agents and low-density.
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Nikita, Mhase* Adinath Sangale Megha salve. "A Comprehensive Review on Floating Drug Delivery System." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1555–65. https://doi.org/10.5281/zenodo.14235838.
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This review was written with the intention of gathering the most recent research on floating drug delivery systems (FDDS), with a particular emphasis on the many kinds of FDDS, their principles, and the mechanism of floating to achieve gastric retention. Systems for delivering drugs that float instantly when they come into touch with the stomach With absorption windows in the upper small intestine, fluids offer intriguing strategies for boosting the bioavailability of medications. The most recent developments in FDDS, such as the formulation and physiological aspects that affect stomach retention and techniques for creating single-unit and multiple-unit floating systems, are covered in detail.The goal of the floating drug delivery system (FDDS) is to prolong the period of stomach stay in order to improve bioavailability and therapeutic efficacy.FDDS releases the drug gradually and regulatedly by allowing the dosage form to float over stomach contents with the use of effervescent agents and low-density.
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Agale, Karan A., and Sanket Pandurang Shinde. "A Review on Floating Tablet." Journal of Drug Delivery and Therapeutics 15, no. 2 (2025): 204–9. https://doi.org/10.22270/jddt.v15i2.7015.
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Floating drug delivery systems (FDDS) are designed with a lower bulk density than gastric fluids, enabling them to remain buoyant in the stomach for extended periods without affecting the gastric emptying rate. While floating on the stomach's contents, these systems release medication in a controlled and sustained manner. Once the drug is fully released, the system disintegrates or is emptied from the stomach. This mechanism increases the Gastric Residence Time (GRT), leading to improved control over fluctuations in plasma drug concentration. To achieve this, FDDS must possess sufficient structural integrity to form a cohesive gel barrier and release the drug gradually while maintaining a density lower than that of gastric fluids. These systems are typically developed using effervescent and non-effervescent approaches that rely on buoyancy mechanisms. Such methodologies are particularly beneficial for delivering drugs with a narrow therapeutic window. Our review aims to provide detailed insights into the pharmaceutical principles guiding the design, classification, and preparation of FDDS. It also explores factors influencing their performance, their advantages, applications, limitations, and potential future advancements in this innovative drug delivery system. Keywords: Floating drug delivery system, Polymer, Gastroretentive system, Prolonged Gastric Retention, Controlled Drug Release.
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Pravin, Bhimrao Navgire Nilesh Paraji Musmade Amol rajendra Dhayarkar V. M. satpute Ghodake S. R. Gajanan Sanap. "Gastro Retentive Drug Delivery Systems: A Review." International Journal in Pharmaceutical Sciences 2, no. 5 (2024): 886–96. https://doi.org/10.5281/zenodo.11210033.
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In the current days, gastro retentive drug delivery systems (GRDDS) receive the great attention because they increase the performance of controlled release dosage forms, which can take orally. It is a widely employed technique to retain the dosage form in the stomach for a long period by releasing the drug slowly. These systems improved the patient compliance, which increases the therapeutic index of drugs. Various physiological barriers associated with the gastro retentive drug delivery systems such as short gastric retentive time, variation in gastric emptying time that can reduced by this technique. To formulate GRDDS various approaches like floating drug delivery systems, non-effervescent drug delivery systems, high density drug delivery systems, bioadhesive systems, magnetic systems, expandable systems etc.,. The present review mainly focuses on the requirements for formulating the GRDDS, various approaches involved in formulation and factors affecting gastric residence time.
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Twinkie Yadav, Twinkie Yadav, Rizwana Khan Rizwana Khan, Bhawna Sharma Bhawna Sharma, and Priyanka Priyanka. "An Overview on Floating Tablets." International Journal of Pharmaceutical Research and Applications 10, no. 3 (2025): 530–38. https://doi.org/10.35629/4494-1003530538.
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Pharmaceutical technology has advanced significantly with the advent of Novel Drug Delivery Systems (NDDS), especially in the area of creating novel and creative formulations intended to increase therapeutic efficacy. In addition to improving the stability, bioavailability, and general safety of pharmaceutical substances, these advanced NDDS play a crucial role in protecting them against several types of degradation that may take place during storage or after administration. Among the wide variety of NDDS floating tablets, there are special benefits and mechanisms catered to particular medical requirements. Additionally, the developed floating tablets show off their exceptional ability to stay afloat in the stomach contents, allowing for the regulated release of medications over a longer time frame. This ultimately improves therapeutic outcomes and gastric retention. The goal of this paper is to present a thorough analysis of floating tablets, covering their mechanism, preparation techniques, and assessment criteria. and conclusion. In order to achieve the best buoyancy and drug release kinetics, major formulation elements such polymer selection, gasgeneration agents, and tablet density are essential. Floating methods are divided into effervescent and non-effervescent systems. The advantages of these sophisticated systems include not just improved drug absorption but also a notable decrease in unfavorable side effects for specific drug classes. Researchers and pharmaceutical professionals looking to create novel and potent floating tablet formulations might use this review as a resource
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Bhosale, Aishwarya Rajendra, Jitendra V. Shinde, and Rajashree S. Chavan. "A Comprehensive Review on Floating Drug Delivery System (FDDS)." Journal of Drug Delivery and Therapeutics 10, no. 6 (2020): 174–82. http://dx.doi.org/10.22270/jddt.v10i6.4461.
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The main goal of any drug delivery system is to achieve desired concentration of the drug in blood or tissue, which is therapeutically effective and non-toxic for a prolonged period. Current pharmaceutical scenario focuses on the formulation of floating drug delivery system (FDDS). FDDS are low density systems that float over the gastric contents and remain buoyant in the stomach for a prolonged period of time without affecting the gastric emptying rate. The aim of writing this review is to compile the current literature with special focus on the principal mechanism of floatation to attain gastric retention. Effervescent FDDS release CO2 gas, thus reduce the density of the system and remain buoyant in the stomach for a prolonged period of time and released the drug slowly at a desired rate so it can be used to prolong the gastric residence time in order to improve the bioavailability of drug. The review briefly describes the mechanism, types of floating system, advantages, limitation, factors affecting floating system, drug candidates suitable for floating, evaluation parameters and application of the system. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form and the future potential of FDDS.
 Keywords: Floating drug delivery system, Absorption Window, Effervescent system, floating lag time.
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Djebbar, Mohamed, Nacéra Chaffai, Fatiha Bouchal, and Noureddine Aouf. "Effervescent floating tablets of metformin HCl developed by melt granulation. Part I: Effect of hydrophilic polymer on biopharmaceutical properties." GSC Biological and Pharmaceutical Sciences 6, no. 2 (2019): 052–67. https://doi.org/10.5281/zenodo.4303950.
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In the present study which the aim to evaluate the effect of hydrophilic polymer on the biopharmaceutical properties of metformin hydrochloride floating tablets, we have prepared floating systems using melt granulation, according to effervescent approach. Two hydrophilic polymers are used at various concentrations (10, 12.5, 15 and 17.5%), Acacia gum and hydroxypropylmethylcellulose (HPMC) at three viscosity grades (K4M, K15M and K100M). In addition to the satisfactory physical parameters, the evaluation of buoyancy and <em>in vitro</em> dissolution of floating developed systems revealed that the biopharmaceutical performances of these systems depended on the nature of the polymer. Unlike the acacia gum which did not produce floating systems, the HPMC matrixes had good buoyancy properties: fast buoyancy time (240±30 to 360±30 sec) and total flotation time more than 24 hours with matrix maintained integrity. In addition, in the case of HPMC, a significant influence of viscosity grade on MTH kinetics has been demonstrated. Indeed, the observed results showed that at 17.5% of HPMC, as the viscosity grade increases, the dissolution kinetics of metformin HCl was extended. The formulations F8 (HPMC K15M) and F12 (HPMC K100M) have exhibited the drug release rates of about 92 and 80% respectively at the end of 8 hours dissolving. These formulations followed Korsmeyer-Peppas/Higuchi release kinetics according to a Non-Fickian mechanism. Finally, the melting granulation process of MTH with stearic acid, in the case of HPMC K100M, used at high concentration (17.5%), has allowed the development of extended-release effervescent floating tablets (> 8 h).
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JADI, RAJENDRA KUMAR, Someshwar Komati, Vishali Dasi, and Narayana Raju Padala. "FORMULATION DEVELOPMENT AND CHARACTERIZATION OF ATAZANAVIR SULPHATE CONTROLLED RELEASE NON-EFFERVESCENT FLOATING MATRIX TABLETS." Journal of Drug Delivery and Therapeutics 9, no. 4-A (2019): 601–7. http://dx.doi.org/10.22270/jddt.v9i4-a.3482.
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The objective of the present work to develop extended-release floating matrix tablets of ATZ, which were designed to prolong the gastric residence time and drug release after oral administration. Different grades of low-density lipid (i.e. ethylcellulose) and Hydroxypropyl methylcellulose (i.e. HPMC K100M) were used to get the desired floating and prolonged release profile over an extended period. All the formulations extended the drug release up to 24 hours and more and the formulations were optimized for the desired release profiles. The release and floating property depended on the polymer type and polymer proportion. The formulation prepared with EC and HPMC K100M (i.e. 10%, 20%, and 30%) has more floating time than the formulation prepared with the EC alone. The optimized formulation (F10) prepared with a combination of EC N100 and HPMC K100M was evaluated for In vivo radiographic study, which shows the floating property for up to 9 hours. The DSC study shows that there is no drug-polymer interaction. This study gives the preliminary idea about the development of the floating drug delivery systems of Atazanavir without the use of a gas generating agent. Keywords: Non-effervescent, extended-release, gastric residence time, buoyancy, lipid aid.
Conference papers on the topic "Non-Effervescent Systems"
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Konstantinov, Dancho D., Philip J. Bowen, Richard Marsh, Peter J. Kay, Andrew P. Crayford, and Marco Derksen. "Developing Effervescent Atomisation for Alternative Fuels." In ASME Turbo Expo 2012: Turbine Technical Conference and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/gt2012-69777.
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A wide range of atomiser types have been developed for industrial applications — such as rotary, pressure, air-assist and air-blast atomisers. Each type works on the principle of applying mechanical or kinetic energy to disintegrate a jet or sheet of liquid fuel, in preparation for combustion. The aim is to sufficiently increase the surface area to volume ratio of the fuel and presents it in a form suitable for a consistent combustion process. Traditional liquid fuels, such as fossil fuels, have been employed for some decades and combustion systems (and atomisers) have been optimised for their use. However, combustion engineers are being increasingly forced to consider the use of alternative, biologically-derived hydrocarbon fuels. Such fuels often have very different viscosities, densities and surface tensions or possess complex, non-linear properties when compared to conventional fuels. Effervescent atomisation is a promising two-phase atomisation technique offering potential improvements in fluid atomisation quality and reductions in fluid operating pressures. It appears particularly well suited to the atomisation of viscous fuels such as biofuels; this applicability to alternative fuels has led to a renewed interest in the method. After an extensive literature review of the current state of this technology [1] an adjustable geometry effervescent atomiser was designed, built and studied at the Cardiff School of Engineering. Water and air were used as the operating fluids. The sprays produced by the atomiser were characterised using a Phase Doppler Anemometry (PDA) system which allowed for simultaneous real-time droplet size and velocity data to be obtained. High quality data was achieved with data rates over 10 kHz and validation rates over 90% in 2-D LDA mode in the high density sprays. A PDA probe designed for dense spray applications was utilised. A number of important operating parameters identified during the literature review phase can be altered on the atomiser, and their effects on fuel spray quality investigated. The operating parameters investigated in this manner included air-to-liquid by mass ratio (ALR), pressure drop as well as a range of geometric parameters. This paper discusses and analyses the influence of ALR on the quality of atomisation and the associated two-phase flow field. Comparisons are made with previous studies and correlations, using earlier versions of the hardware or alternative techniques. Ongoing work will assess and optimise the performance of simulated biofuels mixtures.
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Ghaemi, S., D. S. Nobes, and P. Rahimi. "Effect of Gas-Liquid Ratio on Droplets Centricity and Velocity of an Effervescent Atomizer." In ASME 2008 Fluids Engineering Division Summer Meeting collocated with the Heat Transfer, Energy Sustainability, and 3rd Energy Nanotechnology Conferences. ASMEDC, 2008. http://dx.doi.org/10.1115/fedsm2008-55046.
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Effervescent atomization is a twin fluid atomization mechanism which is based on the injection of gas into a liquid stream at an upstream location of the exit nozzle. This atomization mechanism is capable of producing droplets with Sauter Mean Diameter (SMD) comparable to other types of atomizers but at lower injection pressures. For the conditions investigated in this paper, liquid at the nozzle exit is an annular film surrounding the gas phase. A shadowgraph system is used to visualize particles shape and study droplets evolution in the spray field. Measurement of droplet SMD and centricity has been conducted at several axial and radial locations for different Gas-Liquid Ratios (GLRs). The shadowgraphy images reveal some non-spherical droplets which consist of both elliptical and coalescing droplets. Results also demonstrate that higher numbers of non-spherical droplets are observed at the near nozzle region and at higher liquid flow rate. In this work, spatial structure of the liquid phase velocity field has also been studied using a StereoPIV technique. The velocity field from StereoPIV measurements has been compared with the shadowgraphy velocity results averaged over different droplet size classes. This comparison has been conducted for the atomizer operating at different GLRs. Comparison of the results demonstrates that at the far-field, StereoPIV velocity field measurement is biased toward the velocity of droplets size classes which have relatively higher probability.