Relevant bibliographies by topics / Non-falciparum

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  1. Journal articles

Academic literature on the topic 'Non-falciparum'

Author: Grafiati
Published: 4 June 2021
Last updated: 4 February 2022

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Journal articles on the topic "Non-falciparum"

1

Wångdahl, Andreas, Katja Wyss, Dashti Saduddin, et al. "Severity of Plasmodium falciparum and Non-falciparum Malaria in Travelers and Migrants: A Nationwide Observational Study Over 2 Decades in Sweden." Journal of Infectious Diseases 220, no. 8 (2019): 1335–45. http://dx.doi.org/10.1093/infdis/jiz292.

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Abstract Background The aim was to assess factors affecting disease severity in imported P. falciparum and non-falciparum malaria. Methods We reviewed medical records from 2793/3260 (85.7%) of all episodes notified in Sweden between 1995 and 2015 and performed multivariable logistic regression. Results Severe malaria according to WHO 2015 criteria was found in P. falciparum (9.4%), P. vivax (7.7%), P. ovale (5.3%), P. malariae (3.3%), and mixed P. falciparum episodes (21.1%). Factors associated with severe P. falciparum malaria were age <5 years and >40 years, origin in nonendemic country, pregnancy, HIV, region of diagnosis, and health care delay. Moreover, oral treatment of P. falciparum episodes with parasitemia ≥2% without severe signs at presentation was associated with progress to severe malaria with selected criteria. In non-falciparum, age >60 years, health care delay and endemic origin were identified as risk factors for severe disease. Among patients originating in endemic countries, a higher risk for severe malaria, both P. falciparum and non-falciparum, was observed among newly arrived migrants. Conclusions Severe malaria was observed in P. falciparum and non-falciparum episodes. Current WHO criteria for severe malaria may need optimization to better guide the management of malaria of different species in travelers and migrants in nonendemic areas.
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2

Gomes, Luciano T., Mauro S. Tada, Tony H. Katsuragawa, et al. "Low sensitivity of malaria rapid diagnostic tests stored at room temperature in the Brazilian Amazon Region." Journal of Infection in Developing Countries 7, no. 03 (2013): 243–52. http://dx.doi.org/10.3855/jidc.2564.

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Introduction: In remote areas of the Amazon Region, diagnosis of malaria by microscopy is practically impossible. This study aimed to evaluate the performance of two rapid diagnostic tests (RDTs) targeting different malaria antigens stored at room temperature in the Brazilian Amazon Region. Methodology: Performance of the OptiMal Pf/Pan test and ICT-Now Pf/Pan test was analyzed retrospectively in 1,627 and 1,602 blood samples, respectively. Tests were performed over a 15-month period. Kits were stored at room temperature in five community health centres located in the Brazilian Amazon Region. RDT results were compared with thick blood smear (TBS) results to determine sensitivity, specificity, and accuracy of the RDT. Results: The sensitivities of the OptiMal Pf/Pan test were 79.7% for Plasmodium falciparum malaria diagnosis and 85.7% for non-P. falciparum infections. The results showed a crude agreement of 88.5% for P. falciparum, and 88.3% for non-P. falciparum infections (Kappa index = 0.74 and 0.75, respectively). For the ICT-Now Pf/Pan test (CI 95%), the sensitivities were 87.9% for P. falciparum malaria diagnosis and 72.5% for non-P. falciparum infection. Crude agreement between the ICT-Now Pf/Pan test and TBS was 91.4% for P. falciparum and 79.7% for non-P. falciparum infection. The Kappa index was 0.81 and 0.59 for the final diagnosis of P. falciparum and non-P. falciparum, respectively. Higher levels of parasitaemia were associated with higher crude agreement between RDT and TBS. Conclusions: The sensitivities of RDTs stored at room temperature over a 15-month period and performed in field conditions were lower than those previously reported.
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3

Costa, Laura, Inês Gonçalves, Dina Leal, Luísa Pinto, and Francisco Gonçalves. "A Case of Imported Non-falciparum Malaria." Acta Scientific Medical Sciences 5, no. 7 (2021): 78–80. http://dx.doi.org/10.31080/asms.2020.05.0957.

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4

Doritchamou, Justin Y. A., Richard A. Akuffo, Azizath Moussiliou, et al. "Submicroscopic placental infection by non-falciparum Plasmodium spp." PLOS Neglected Tropical Diseases 12, no. 2 (2018): e0006279. http://dx.doi.org/10.1371/journal.pntd.0006279.

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5

Kullu, Bipin K., Chakradhar Majhi, Butungeshwar Pradhan, and Deepak K. Swain. "Lipid profiles among Plasmodium falciparum infected, non malarial febrile patients and volunteers." International Journal of Advances in Medicine 5, no. 3 (2018): 556. http://dx.doi.org/10.18203/2349-3933.ijam20181661.

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Background: Acute falciparum Malaria infected patients show wide ranges of metabolic derangement including changes in serum lipid profiles. The exact mechanisms of this derangement in serum lipid profiles are still poorly understood. Objective was to study the lipid profiles among acute plasmodium falciparum infected patients.Methods: It was a Prospective observational comparative study. A total of 100 patients were consecutively taken in the study. Fifty Non- malaria febrile cases and 50 healthy volunteers were taken as control group. Baseline lipid profiles were estimated in all cases at the time of admission and at the end of one week. Data were collected and analyzed.Results: There were 100 diagnosed cases of falciparum malaria and 50 non malarial febrile and 50 healthy volunteers taken as control group. Complications was present in 50 and 50 were uncomplicated. Serum total cholesterol, HDL and LDL levels were significantly low in falciparum malaria patients, and serum TG and VLDL levels were higher than control. There were no significant changes in mean serum lipids profiles in survived and deaths cases.Conclusions: The derangement in lipid profiles in falciparum malaria was characteristic and specific for the disease. Characteristic changes were lower HDL, LDL and total cholesterol levels and higher TG and VLDL levels in comparison to control groups. Changes are more pronounced in complicated falciparum Malaria and persisting till the end of the week. These findings may be of diagnostic and prognostic value.
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6

Kanda-Taniguchi, Tomoyo, Kaiissar Md Mannoor, Changchun Li та ін. "Essential Role of γδT Cells In Naturally Acquired Immunity to Falciparum Malaria". Blood 116, № 21 (2010): 4877. http://dx.doi.org/10.1182/blood.v116.21.4877.4877.

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Abstract Abstract 4877 It is important to understand the mechanisms of naturally acquired immunity to malaria for the development of effective malaria vaccines. We have demonstrated that γδT cells expanded in the peripheral blood of the falciparum malaria patients in Thailand but did not expand in patients living in malaria endemic areas of Laos. However, the percentage of Vγ9-T cells, a γδT cell subset, increased in the Laos patients. The levels of naturally acquired antibodies to crude P. falciparum (Pf) antigens also increased with an age dependent manner in individuals living in endemic areas of Laos. In this study, we further investigated the role of Vγ9-T cells in naturally acquired immunity to the falciparum malaria. The peripheral blood lymphocytes (PBLs) and plasma obtained from hospitalized uncomplicated falciparum malaria patients (UMPs) and severe falciparum malaria patients (SMPs) in Thailand and from non-hospitalized UMPs living in endemic areas of Laos were analyzed. The plasma levels of IL-10, which is anti-inflammatory cytokine and associated with antibody production from B cells, were elevated in both hospitalized and non-hospitalized falciparum malaria patients. There was a correlation between the levels of IL-10 and the percentage of Vγ9-T cells in γδT cells. IL-10 and Pf specific antibodies were detected only in culture supernatant of PBLs from non-hospitalized UMPs in the presence of IL-2 for 2 wks. These results indicate that Vγ9-T cells may contribute to acquiring natural immunity to malaria. Disclosures: No relevant conflicts of interest to declare.
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7

Amita Priya, D., K. Meena Kumari, Muralidhar Varma, et al. "Treatment Outcome Analysis of Artemisinin based Therapy in Plasmodium falciparum Infection: An Observational Study." Biomedical and Pharmacology Journal 11, no. 4 (2018): 1857–63. http://dx.doi.org/10.13005/bpj/1558.

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Currently, the preferred treatment for chloroquine (CQ) resistant Plasmodium falciparum (Pf) is Artemisinin combination therapy (ACT). Our aim was to assess the artemisinin based treatment outcomes in patients with Plasmodium falciparum infection. Patients with falciparum infection from a tertiary health care centre in South India were enrolled in this study. It was a non-randomised observational study .The data regarding peripheral blood smear, complete blood count, liver, renal function tests and the treatment given was documented at admission and on the day of discharge. Patients with uncomplicated falciparum malaria were most common. Artesunate and doxycycline was the most common combination used at our centre (54.6%) followed by artemether –lumefantrine. All patients had peripheral smear negative for Plasmodium falciparum parasite by the end of treatment. There was improvement in blood count,liver and renal function tests. Artemisinin based combination therapy was effective in treatment of falciparum malaria.
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8

Plucinski, Mateusz M., Camelia Herman, Sophie Jones, et al. "Screening forPfhrp2/3-DeletedPlasmodium falciparum, Non-falciparum, and Low-Density Malaria Infections by a Multiplex Antigen Assay." Journal of Infectious Diseases 219, no. 3 (2018): 437–47. http://dx.doi.org/10.1093/infdis/jiy525.

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9

MEHDI, SYED GHAZANFAR, and NAEEM NAQI. "FALCIPARUM MALARIA." Professional Medical Journal 18, no. 01 (2011): 64–68. http://dx.doi.org/10.29309/tpmj/2011.18.01.1860.

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Introduction: Quinine and quinidines remain the drugs of choice for chloroquine resistant Plasmodium falciparum malaria. In 1972, Chinese scientists discovered the antimalarial properties of a group of compounds from the qinghao plant (Artemisia annua) which have activity against all malaria causing parasites including multi-drug resistant strains of Plasmodium falciparum. Objective: To compare response to treatment between quinine and artemether in Plasmodium falciparum malaria. Design: Quasi-experimental study. Setting: Department of Medicine Pakistan Air Force Hospital Lahore. Period: 1st Jun 2008 to 1st Dec 2009. Patients: 80 consecutive adult patients with positive MP slide for Plasmodium falciparum malaria. Methods: Patients were randomly divided into two groups for treatment either with quinine or artemether. Results: Out of total 80 patients, 40 were given quinine and 40 were given artemether. Out of 40, 16 patients responded to quinine while 24 did not respond. The responders were 34.8% in case of quinine while 70.6% patients did not respond. Out of 40 patients treated with artemether, 30 responded while 10 did not. The responders were 65.2%while non responders were 29.4%.0n calculating the P-value from the chi-square it was found that difference in terms of response to the two treatment regimens was statistically significant.(P=.0022).Conclusion: The frequency of response in case of quinine was 34.8% while it was 65.2% in case of artemether. So based upon statistically significant difference (P=.0022) it is concluded that Artemether is a satisfactory alternative to Quinine for the treatment of falciparum malaria in adults.
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10

van den Hoogen, Lotus L., Camelia Herman, Jacquelin Présumé, et al. "Rapid Screening for Non-falciparum Malaria in Elimination Settings Using Multiplex Antigen and Antibody Detection: Post Hoc Identification of Plasmodium malariae in an Infant in Haiti." American Journal of Tropical Medicine and Hygiene 104, no. 6 (2021): 2139–45. http://dx.doi.org/10.4269/ajtmh.20-1450.

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Abstract.Haiti is targeting malaria elimination by 2025. The Grand’Anse department in southwestern Haiti experiences one-third to half of all nationally reported Plasmodium falciparum cases. Although there are historical reports of Plasmodium vivax and Plasmodium malariae, today, non-falciparum infections would remain undetected because of extensive use of falciparum-specific histidine-rich protein 2 (HRP2) rapid diagnostic tests (RDT) at health facilities. A recent case–control study was conducted in Grand’Anse to identify risk factors for P. falciparum infection using HRP2-based RDTs (n = 1,107). Post hoc multiplex Plasmodium antigenemia and antibody (IgG) detection by multiplex bead assay revealed one blood sample positive for pan-Plasmodium aldolase, negative for P. falciparum HRP2, and positive for IgG antibodies to P. malariae. Based on this finding, we selected 52 samples with possible P. malariae infection using IgG and antigenemia data and confirmed infection status by species-specific PCR. We confirmed one P. malariae infection in a 6-month-old infant without travel history. Congenital P. malariae could not be excluded. However, our finding—in combination with historical reports of P. malariae—warrants further investigation into the presence and possible extent of non-falciparum malaria in Haiti. Furthermore, we showed the use of multiplex Plasmodium antigen and IgG detection in selecting samples of interest for subsequent PCR analysis, thereby reducing costs as opposed to testing all available samples by PCR. This is of specific use in low-transmission or eliminating settings where infections are rare.
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