Relevant bibliographies by topics / Non GBM human brain cells

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  1. Journal articles
  2. Dissertations / Theses
  3. Book chapters
  4. Conference papers

Academic literature on the topic 'Non GBM human brain cells'

Author: Grafiati
Published: 3 June 2025
Last updated: 31 July 2025

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Journal articles on the topic "Non GBM human brain cells"

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Cheng, Jiying, Min Li, Charlotte Flüh, et al. "TMIC-76. HUMANIN RELEASE FROM TUMOR ASSOCIATED MYELOID CELLS PROMOTES GLIOMA CHEMORESISTANCE." Neuro-Oncology 24, Supplement_7 (2022): vii288. http://dx.doi.org/10.1093/neuonc/noac209.1119.

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Abstract Transcriptomic screens of brain tumor (glioblastoma; GBM) parenchymal cells indicated tumor supporting traits of the GBM microenvironment, but largely excluded mitochondrially enriched gene-sets. Here, we show that a mitochondrial transcript of GBM parenchymal cells contributes to therapy resistance. We inspected the non-coding transcriptome of human GBM associated myeloid cells (GAM) and observed an upregulation of the mitochondrial ribosomal subunit MT-RNR2, which contains an open reading frame for the signaling peptide humanin. Immunohistology disclosed that humanin was preponderan
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Jiang, Michael Q., Shan Ping Yu, Takira Estaba, et al. "Reprogramming Glioblastoma Cells into Non-Cancerous Neuronal Cells as a Novel Anti-Cancer Strategy." Cells 13, no. 11 (2024): 897. http://dx.doi.org/10.3390/cells13110897.

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Glioblastoma Multiforme (GBM) is an aggressive brain tumor with a high mortality rate. Direct reprogramming of glial cells to different cell lineages, such as induced neural stem cells (iNSCs) and induced neurons (iNeurons), provides genetic tools to manipulate a cell’s fate as a potential therapy for neurological diseases. NeuroD1 (ND1) is a master transcriptional factor for neurogenesis and it promotes neuronal differentiation. In the present study, we tested the hypothesis that the expression of ND1 in GBM cells can force them to differentiate toward post-mitotic neurons and halt GBM tumor
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Wang, Mary, Arin N. Graner, Bryne Knowles, et al. "Differential Effects of Extracellular Vesicles from Two Different Glioblastomas on Normal Human Brain Cells." Neurology International 16, no. 6 (2024): 1355–84. http://dx.doi.org/10.3390/neurolint16060103.

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Background/Objectives: Glioblastomas (GBMs) are dreadful brain tumors with abysmal survival outcomes. GBM extracellular vesicles (EVs) dramatically affect normal brain cells (largely astrocytes) constituting the tumor microenvironment (TME). We asked if EVs from different GBM patient-derived spheroid lines would differentially alter recipient brain cell phenotypes. This turned out to be the case, with the net outcome of treatment with GBM EVs nonetheless converging on increased tumorigenicity. Methods: GBM spheroids and brain slices were derived from neurosurgical patient tissues following inf
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Yadav, Poonam, Raghupathy Vengoji, David Doss, Maneesh Jain, Surinder Batra, and Nicole Shonka. "EXTH-65. EXPLORING ANTIHISTAMINES TO TREAT GLIOBLASTOMA." Neuro-Oncology 26, Supplement_8 (2024): viii251. http://dx.doi.org/10.1093/neuonc/noae165.0995.

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Abstract BACKGROUND Glioblastoma (GBM) is an aggressive and lethal primary malignant brain tumor with a 5-year survival of 6.8%. Interestingly, people with allergies, atopy, or asthma are less likely to develop GBM. A recent study recognized that high histamine receptor 1 (HRH1) expression is inversely related to overall and progression-free survival. METHODS We used a bioinformatics tool, iLINCS, which, after analyzing 99 GBM and 38 healthy samples, identified 36 drugs that can reverse GBM signatures. Based on the concordance score and blood-brain barrier permeability, we selected bromphenira
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Takei, Jun, Ken Furudate, Opeyemi Iwaloye, et al. "TMOD-31. SINGLE-CELL PROFILING AND CHARACTERIZATION OF PATIENT-DERIVED XENOGRAFT GLIOBLASTOMA MODEL IN HUMANIZED MICE." Neuro-Oncology 26, Supplement_8 (2024): viii326. http://dx.doi.org/10.1093/neuonc/noae165.1295.

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Abstract Glioblastoma (GBM) is the most common and aggressive malignant brain tumor in adults, and the current standard therapy has limited efficacy. To develop effective therapies, it is desirable to develop an animal model that can replicate the tumor heterogeneity and immune microenvironment of human GBM. Here, we describe a novel GBM mouse model established with a patient-derived xenograft (PDX) in humanized mice harboring a nearly complete human immune environment. Humanized mice were generated by engrafting human CD34+ hematopoietic stem cells from umbilical cord blood into immunocomprom
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Kanji, Suman, Nozomi Tomimatsu, Luis Fernando Macedo Di Cristofaro, et al. "DNAR-12. ATR INHIBITION AS A NOVEL RADIOSENSITIZATION STRATEGY FOR GLIOBLASTOMA." Neuro-Oncology 25, Supplement_5 (2023): v100—v101. http://dx.doi.org/10.1093/neuonc/noad179.0378.

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Abstract Glioblastomas (GBM) are lethal brain tumors for which surgical resection followed by ionizing radiation (IR) with concurrent and adjuvant Temozolomide (TMZ) remains the mainstay of therapy. GBMs are extremely radioresistant, and radiosensitization approaches are desperately needed for these tumors. IR induces DNA double-strand breaks (DSBs), and these lesions can be repaired either by error-prone non-homologous end joining (NHEJ) or the error-free homologous recombination (HR) pathway. Research in our and other laboratories has shown that the ATR kinase promotes the HR pathway. We the
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Lee, Hyeji, Kanghye Bae, Ah-Rum Baek, et al. "Glioblastoma-Derived Exosomes as Nanopharmaceutics for Improved Glioma Treatment." Pharmaceutics 14, no. 5 (2022): 1002. http://dx.doi.org/10.3390/pharmaceutics14051002.

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The use of cancer-derived exosomes has been studied in several cancer types, but the cancer-targeting efficacy of glioma-derived exosomes has not been investigated in depth for malignant glioblastoma (GBM) cells. In this study, exosomes were derived from U87MG human glioblastoma cells, and selumetinib, a new anticancer drug, was loaded into the exosomes. We observed the tropism of GBM-derived exosomes in vitro and in vivo. We found that the tropism of GBM-derived exosomes is in contrast to the behavior of non-exosome-enveloped drugs and non-GBM-specific exosomes in vitro and in vivo in an anim
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Zhai, Lijie, Galina Gritsina, Brenda Nyugen, et al. "IMMU-32. NON-METABOLIC IDO ACTIVITY INCREASES COMPLEMENT FACTOR H LEVELS WHICH ENHANCES IMMUNOSUPPRESSION IN HUMAN GLIOBLASTOMA." Neuro-Oncology 22, Supplement_2 (2020): ii111. http://dx.doi.org/10.1093/neuonc/noaa215.462.

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Abstract Indoleamine 2,3 dioxygenase 1 (IDO) is an immunosuppressive factor expressed in ≥90% of patient resected glioblastoma (GBM). Canonically, IDO suppresses the immune response by metabolizing the essential amino acid, tryptophan, into the downstream metabolite, kynurenine. Based on the in vivo finding that the genetic knockout of tumor cell IDO does not change brain tumor tryptophan and kynurenine levels in syngeneic mice, we recently questioned the mechanistic role of IDO in GBM. To determine whether tumor cell tryptophan metabolism is responsible for the pathogenic effects of IDO, we c
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El-Ayoubi, Ali, Moritz Klawitter, Jakob Rüttinger, et al. "Intranasal Delivery of Oncolytic Adenovirus XVir-N-31 via Optimized Shuttle Cells Significantly Extends Survival of Glioblastoma-Bearing Mice." Cancers 15, no. 20 (2023): 4912. http://dx.doi.org/10.3390/cancers15204912.

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A glioblastoma (GBM) is an aggressive and lethal primary brain tumor with restricted treatment options and a dismal prognosis. Oncolytic virotherapy (OVT) has developed as a promising approach for GBM treatment. However, reaching invasive GBM cells may be hindered by tumor-surrounding, non-neoplastic cells when the oncolytic virus (OV) is applied intratumorally. Using two xenograft GBM mouse models and immunofluorescence analyses, we investigated the intranasal delivery of the oncolytic adenovirus (OAV) XVir-N-31 via virus-loaded, optimized shuttle cells. Intranasal administration (INA) was se
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Yoon, Seon-Jin, Ran Joo Choi, Yoojung Oh, et al. "STEM-12. DISCOVERY THE ORIGIN-CELLS FOR HUMAN GLIOBLASTOMA GENESIS IN SUBVENTRICULAR ZONE." Neuro-Oncology 24, Supplement_7 (2022): vii33. http://dx.doi.org/10.1093/neuonc/noac209.129.

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Abstract Human glioblastoma (GBM), originating from the subventricular zone (SVZ), occurs due to molecular disruptions in chromosomes. Most GBM tissues exhibit definitive chromosomal patterns: copy-number-variations (CNV) in chromosome 7 (gain) and 10 (loss), known as the earliest molecular events. Herein, we hypothesised that the origin-cells in SVZ of GBM patients can provide clues regarding these chromosomal alterations. We compared bulk RNA sequencing (RNAseq) data of GBM tumor tissue (n=126), tumour free GBM SVZ (n=40), and tumor-free control SVZ of non-glial tumor (n=9). Paired single-ce
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Dissertations / Theses on the topic "Non GBM human brain cells"

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Chuang, Ying Ying, and 莊穎瑩. "The effects of Danthron on the cell cycle and apoptosis of human brain glioblastoma multiforms GBM 8401 cells." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/3jrkh6.

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碩士<br>元培科技大學<br>醫學檢驗生物技術研究所<br>97<br>Danthron (1,8-dihydroxyanthraquinone), one of component from Rheum palmatum L. (Polygonaceae), is an effective component of nature Chinese herb medicine and has been shown several biological activities inclusive of with a powerful anti-tumor activity. For the effects on protein function, Danthron is considered as a tyrosine kinase inhibitor. Danthron can not only inhibit tyrosine kinase signal pathway, proliferation and metastasis ability of cancer cells but induce apoptosis of cancer cells, including lung cancer and breast cancer etc. In addition, Danthron
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Chu, Jao-Jia, and 朱兆嘉. "The Effect of Paclitaxel on Protein Phosphorylation and Reorganization of Intermediate Filaments in Rat Brain Tumor Cells and Human Non-small Cell Lung Cancer Cells." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/46991103396193447955.

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博士<br>國立清華大學<br>生命科學系<br>93<br>we report that taxol induces hyperphosphorylation and reorganization of the vimentin intermediate filament in 9L rat brain tumor cells, in concentration- and time-dependent manner. Phosphorylation of vimentin was maximum at10-6 M of taxol treatment for 8 h and diminished at higher (10-5 M) concentration. Enhanced phosphorylation of vimentin was detectable at 2 h treatment with 10-6 M taxol and was maximum after 12 h of treatment. Taxol-induced phosphorylation of vimentin was largely abolished in cells pretreated with staurosporine and bisindolymaleimide but was u
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Book chapters on the topic "Non GBM human brain cells"

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Braak, H., and E. Braak. "Chapter 12 Ratio of pyramidal cells versus non-pyramidal cells in the human frontal isocortex and changes in ratio with ageing and Alzheimer's disease." In Progress in Brain Research. Elsevier, 1986. http://dx.doi.org/10.1016/s0079-6123(08)64305-8.

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J. Adam, Ryan, and Ei Terasawa. "Regulation of GnRH Release by Neuroestrogens in Non-human Primates." In Sex Steroid Hormones - Impact on Reproductive Physiology [Working Title]. IntechOpen, 2025. https://doi.org/10.5772/intechopen.1008513.

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This chapter summarizes recent progress in reproductive neuroendocrinology in rhesus monkeys as a model for humans. First, to characterize properties of primate GnRH neurons, GnRH neurons are isolated from rhesus monkey embryos and cultured, and human GnRH neurons are generated from induced pluripotent human stem cells. Results from cultured GnRH neurons indicate that exposure to estradiol rapidly stimulates firing activity, increases Ca2+ oscillations, synchronization of Ca2+ oscillations among GnRH neurons, and estrogen-induced GnRH release. Second, we describe a series of findings in vivo,
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Puce, Aina, and David Perrett. "Electrophysiology and brain imaging of biological motion." In The Neuroscience of Social Interaction. Oxford University PressOxford, 2004. http://dx.doi.org/10.1093/oso/9780198529255.003.0001.

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Abstract The movements of the faces and bodies of other conspecifics provide stimuli of considerable interest to the social primate. Studies of single cells, field potential recordings and functional neuroimaging data indicate that specialized visual mechanisms exist in the superior temporal sulcus (STS) of both human and non-human primates that produce selective neural responses to moving natural images of faces and bodies. STS mechanisms also process simplified displays of biological motion involving point lights marking the limb articulations of animate bodies and geometrical shapes whose m
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Hornedo-Ortega, Ruth, Zuriñe Rasines-Perea, Ana B. Cerezo, Pierre-Louis Teissedre, and Michael Jourdes. "Anthocyanins: Dietary Sources, Bioavailability, Human Metabolic Pathways, and Potential Anti-Neuroinflammatory Activity." In Phenolic Compounds - Chemistry, Synthesis, Diversity, Non-Conventional Industrial, Pharmaceutical and Therapeutic Applications. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.99927.

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The objectives of this chapter are to summarize and discuss (i) the anthocyanins structure and content in foodstuffs and their dietary intake (ii) the anthocyanins bioavailability and human metabolic pathways and (iii) the in vitro and in vivo potent anti-neuroinflammatory effects of anthocyanins and their metabolites. Indeed, anthocyanins are polyphenolic compounds belonging to the group of flavonoids, and are one of the most commonly consumed polyphenols in a normal diet. They are responsible of red, blue and purple color of several fruits and vegetables and their intake has been related wit
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Dahiya, Vineet, Krishana Karak, and Sahana Lokesh R. "ELIMINATION OF OCULAR ARTIFACTS FROM EEG SIGNALS USING ADAPTIVE LEARNING TECHNIQUESPERFORMANCE OF QUANTUM DOT BASED INTERMEDIATE BAND SOLAR CELLS." In 9th National Conference & Exhibition on Emerging and Innovative Trends in Engineering Technology (NCEEITET). IARS' Press Australia, 2023. https://doi.org/10.62431/rn053p58.

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Mind-machine connections have captivated humans since their conception. From conception, this has been true. Neurobiology and engineering advances are making this notion more feasible. This allows future research to increase human mental and physical talents and even regain them. BCI research has several possible uses. These uses include entertainment, education, telepresence, human evolution, and debunking lies. Brain-computer interfaces were initially developed to help severely handicapped persons communicate. Early BCI systems had sluggish velocities, a high error rate, hypersensitivity to
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Braak Heiko and Del Tredici Kelly. "Evolutional Aspects of Alzheimer's Disease Pathogenesis." In Advances in Alzheimer’s Disease. IOS Press, 2013. https://doi.org/10.3233/978-1-61499-154-0-155.

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Tau lesions (pretangles, neuropil threads, neurofibrillary tangles) that develop in a few types of nerve cells in the brain are essential to the pathogenesis of Alzheimer's disease (AD). The formation of non-argyrophilic pretangles marks the beginning of the pathological process and is of increasing interest because it is temporally closer to the prevailing conditions that induce the pathological process underlying AD in contrast to late-stage disease. Not all of the pretangle material, however, converts into argyrophilic neurofibrillary lesions. The propensity to develop tau lesions may be re
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Wang, Xinlong, Francisco Gonzalez-Lima, and Hanli Liu. "Transcranial Infrared Laser Stimulation." In The Oxford Handbook of Transcranial Stimulation, Second Edition, 2nd ed. Oxford University Press, 2022. http://dx.doi.org/10.1093/oxfordhb/9780198832256.013.10.

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Abstract As part of transcranial photobiomodulation, transcranial infrared laser stimulation (TILS) refers to the non-invasive delivery of 1064 nm wavelength infrared laser light to the brain to modulate energy metabolism and hemodynamics. The primary mechanism rests on the photo-oxidation of cytochrome-c-oxidase, the key mitochondrial enzyme that catalyzes oxygen utilization in animal cells. Since brain physiology is dependent on oxygenation for energy production, TILS modulates brain activity. Placebo-controlled TILS effects were demonstrated in vivo by broadband near-infrared spectroscopy a
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Anand, Rohit, Neha Radharapu, Pratiksha Pradhan, and Rajesh Birok. "Removal of EOG Artefact from EEG – A Review." In Advances in Transdisciplinary Engineering. IOS Press, 2022. http://dx.doi.org/10.3233/atde220783.

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An electroencephalogram (EEG) is a medical examination that records the electrical activity of the human brain. In order to record these signals, electrodes are placed on the scalp, and these electrodes detect any activity of the brain cells. This result is used to diagnose patients with epilepsy, sleep disorders, brain tumors, seizure disorders, and brain disorders. However, these signals are often corrupted by various artefacts either generated from the human body(physiological) or the electrical apparatus used(non-physiological). The removal of these artefacts is vital as their presence may
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Konofagou, Elisa E. "Blood–Brain Barrier Opening and Drug Delivery Using Focused Ultrasound and Microbubbles." In Neurobiology of Mental Illness, edited by Karl Deisseroth. Oxford University Press, 2013. http://dx.doi.org/10.1093/med/9780199934959.003.0011.

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Current treatments of neurological and neurodegenerative diseases are limited due to the lack of a truly non-invasive, transient, and regionally selective brain drug delivery method. The brain is particularly difficult to deliver drugs to because of the blood-brain barrier (BBB). The impermeability of the BBB is due to the tight junctions connecting adjacent endothelial cells and highly regulatory transport systems of the endothelial cell membranes. The main function of the BBB is ion and volume regulation to ensure conditions necessary for proper synaptic and axonal signaling. However, the sa
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Vázquez-Mendoza, Alicia, Danielle Vannan, Evelin G. Morales, Marisol I. González, and José Luis Reyes Hernández. "Lymphocytes in Dry Eye Disease." In Dry Eye [Working Title]. IntechOpen, 2021. http://dx.doi.org/10.5772/intechopen.98969.

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The eye is a delicate organ that, along with other tissues such as the testicles and brain, is considered immune-privileged. Immune cells that reside in the eye must create a tolerogenic microenvironment to prevent unwanted aggressive inflammatory reactions that can compromise function. However, the eye is exposed to persistent environmental insult that may overwhelm immune tolerance and result in eye diseases from diverse origins (autoimmune, infectious, and inflammatory). The immune system plays a central role in the different phases of eye diseases, as alterations in immune cells in respons
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Conference papers on the topic "Non GBM human brain cells"

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Mess, Griffin, Rasika Thombre, Max Kerensky, et al. "Designing a Murine Model of Human Glioblastoma Brain Tumor: Development of a Platform for Validation Using Ultrasound Elastography." In 2022 Design of Medical Devices Conference. American Society of Mechanical Engineers, 2022. http://dx.doi.org/10.1115/dmd2022-1025.

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Abstract Glioblastoma Multiforme (GBM) is a malignant brain cancer with low overall survival. Therefore, researchers are looking to augment its current therapeutic regimen, which includes surgical tumor resection, chemotherapy and radiation. A promising treatment modality, focused ultrasound, has been used as a non-invasive treatment for GBM through multiple approaches such as thermal ablation, immunomodulation, and blood brain barrier disruption. In order to develop these treatments for clinical trials, testing in animal models needs to be performed to investigate the efficacy of the treatmen
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Guerrero-Cazares, Hugo, Emily Lavell, Gabrielle Drummond, et al. "Abstract 444: Slit2 stimulation induces a chemorepellent effect on the migration of human GBM brain tumor initiating cells." In Proceedings: AACR 106th Annual Meeting 2015; April 18-22, 2015; Philadelphia, PA. American Association for Cancer Research, 2015. http://dx.doi.org/10.1158/1538-7445.am2015-444.

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Abbadi, Sara, Hugo Guerrero-Cazares, Ameer Abutaleb, et al. "Abstract 5422: Human GBM-derived brain tumor stem cells resist glycolysis inhibition through Glucose 6 phosphatase: a potential clinical implication in the treatment of recurrent brain tumors." In Proceedings: AACR 104th Annual Meeting 2013; Apr 6-10, 2013; Washington, DC. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.am2013-5422.

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Shettigar, Nandan, C. Steve Suh, and Debjyoti Banerjee. "On Developing a Novel Brain-On-Chip Platform for Enhanced Control and Design of 3D Neural Circuit Informational Dynamics." In ASME 2024 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2024. https://doi.org/10.1115/imece2024-147442.

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Abstract Characterizing, monitoring, and controlling neural dynamics remains an elusive goal for research efforts ranging from neuroscience to computer science. The approaches attempt to unearth a richer interpretation for the nonlinear, time-varying hierarchy of biological hardware organizations. Some promising advances with specific investigations focusing on classes of problems pertaining to how emergent neural network dynamics produces 1) distinct cognitive states including degenerative pathologies and 2) reproducing, maintaining and controlling efficient information processing capabilitie
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Sotudeh-Chafi, M., N. Abolfathi, A. Nick, V. Dirisala, G. Karami, and M. Ziejewski. "A Multi-Scale Finite Element Model for Shock Wave-Induced Axonal Brain Injury." In ASME 2008 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2008. http://dx.doi.org/10.1115/sbc2008-192342.

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Traumatic brain injuries (TBIs) involve a significant portion of human injuries resulting from a wide range of civilian accidents as well as many military scenarios. Axonal damage is one of the most common and important pathologic features of traumatic brain injury. Axons become brittle when exposed to rapid deformations associated with brain trauma. Accordingly, rapid stretch of axons can damage the axonal cytoskeleton, resulting in a loss of elasticity and impairment of axoplasmic transport. Subsequent swelling of the axon occurs in discrete bulb formations or in elongated varicosities that
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"Impact of Heparan Sulphate Binding Domain of Chemokine CCL21 to Migration of Breast Cancer Cells." In Qatar University Annual Research Forum & Exhibition. Qatar University Press, 2020. http://dx.doi.org/10.29117/quarfe.2020.0132.

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Lymph node metastasis constitutes a key event in breast cancer progression. Chemokines are small proteins, which can promote metastatic spread by inducing cancer cell migration and invasion. Chemokine function is dependant upon their binding to both cell surface heparan sulphate (HS) molecules and to their specific receptor. Our group has demonstrated a significant increase in chemokine receptor CCR7 expression in cancerous breast epithelia compared to healthy controls. This study is designed to test the hypothesis that a non-HS binding forms of chemokine CCL21 can disrupt the normal response
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Fukuda, Shuichi. "Another AI - Analog Intelligence." In 13th International Conference on Human Interaction & Emerging Technologies: Artificial Intelligence & Future Applications. AHFE International, 2025. https://doi.org/10.54941/ahfe1005895.

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Al is often thought of as something artificial, i.e., the man­ made world. However, we should remember that prompts are important in Al. In short, what Al did is it simply expanded search space due to advances in computing machines. Decision-making on how to set up the search space and how to search, that is, the strategy, is instructed by humans. The same is true for generative Al. A decision must be made as to how to carry out generation and it is humans that make such decisions. The current computing is based on 0-1, so digitalization is emphasized, but the real world is analog. Digitalizat
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