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Journal articles on the topic 'Non-invasive biosensors- Clinical analysis'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

Guilbault, G. "Non-invasive biosensors in clinical analysis." Biosensors and Bioelectronics 10, no. 3-4 (1995): 379–92. http://dx.doi.org/10.1016/0956-5663(95)96856-t.

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Wu, Chenyu. "Non-Invasive Wearable Sweat and Tear-Based Biosensors for Continuous Health Monitoring." Highlights in Science, Engineering and Technology 55 (July 9, 2023): 205–10. http://dx.doi.org/10.54097/hset.v55i.9959.

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Over the years, the continuous advancements within the wearable biosensor field have raised public awareness in exploring new strategies for people's personalized point-of-care testing. Biosensors are multifunctional devices that allow people to quantify a range of biological signals through highly sensitive and small-scale sensing platforms, thus providing users convenience when limiting the need for clinical check-ups and laboratory diagnosis. Via dynamic, non-invasive evaluation of biomarkers in bodily fluids, biosensors are able to provide users with a nearly instant numerical result of th

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Xu, Jing, Yunsheng Fang, and Jun Chen. "Wearable Biosensors for Non-Invasive Sweat Diagnostics." Biosensors 11, no. 8 (2021): 245. http://dx.doi.org/10.3390/bios11080245.

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Recent advances in microfluidics, microelectronics, and electrochemical sensing methods have steered the way for the development of novel and potential wearable biosensors for healthcare monitoring. Wearable bioelectronics has received tremendous attention worldwide due to its great a potential for predictive medical modeling and allowing for personalized point-of-care-testing (POCT). They possess many appealing characteristics, for example, lightweight, flexibility, good stretchability, conformability, and low cost. These characteristics make wearable bioelectronics a promising platform for p

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Takke, Anjali, and Pravin Shende. "Non-invasive Biodiversified Sensors: A Modernized Screening Technology for Cancer." Current Pharmaceutical Design 25, no. 38 (2019): 4108–20. http://dx.doi.org/10.2174/1381612825666191022162232.

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Background: Biological sensors revolutionize the method of diagnoses of diseases from early to final stages using the biomarkers present in the body. Biosensors are advantageous due to the involvement of minimal sample collection with improved specificity and sensitivity for the detection of biomarkers. Methods: Conventional biopsies restrict problems like patient non-compliance, cross-infection and high cost and to overcome these issues biological samples like saliva, sweat, urine, tears and sputum progress into clinical and diagnostic research for the development of non-invasive biosensors.

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Sardini, Emilio, Mauro Serpelloni, and Sarah Tonello. "Printed Electrochemical Biosensors: Opportunities and Metrological Challenges." Biosensors 10, no. 11 (2020): 166. http://dx.doi.org/10.3390/bios10110166.

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Printed electrochemical biosensors have recently gained increasing relevance in fields ranging from basic research to home-based point-of-care. Thus, they represent a unique opportunity to enable low-cost, fast, non-invasive and/or continuous monitoring of cells and biomolecules, exploiting their electrical properties. Printing technologies represent powerful tools to combine simpler and more customizable fabrication of biosensors with high resolution, miniaturization and integration with more complex microfluidic and electronics systems. The metrological aspects of those biosensors, such as s

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Alduais, Ahmed, Hessah Saad Alarifi, and Hind Alfadda. "Using Biosensors to Detect and Map Language Areas in the Brain for Individuals with Traumatic Brain Injury." Diagnostics 14, no. 14 (2024): 1535. http://dx.doi.org/10.3390/diagnostics14141535.

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The application of biosensors in neurolinguistics has significantly advanced the detection and mapping of language areas in the brain, particularly for individuals with brain trauma. This study explores the role of biosensors in this domain and proposes a conceptual model to guide their use in research and clinical practice. The researchers explored the integration of biosensors in language and brain function studies, identified trends in research, and developed a conceptual model based on cluster and thematic analyses. Using a mixed-methods approach, we conducted cluster and thematic analyses

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Sardarabadi, Parvaneh, Amir Asri Kojabad, Davod Jafari, and Cheng-Hsien Liu. "Liquid Biopsy-Based Biosensors for MRD Detection and Treatment Monitoring in Non-Small Cell Lung Cancer (NSCLC)." Biosensors 11, no. 10 (2021): 394. http://dx.doi.org/10.3390/bios11100394.

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Globally, non-small cell lung cancer (NSCLC) is the leading cause of cancer deaths. Despite advancements in chemotherapy and targeted therapies, the 5-year survival rate has remained at 16% for the past forty years. Minimal residual disease (MRD) is described as the existence of either isolated tumour cells or circulating tumour cells in biological liquid of patients after removal of the primary tumour without any clinical signs of cancer. Recently, liquid biopsy has been promising as a non-invasive method of disease monitoring and treatment guidelines as an MRD marker. Liquid biopsy could be

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Saha, Soumyadeep, Manoj Sachdev, and Sushanta K. Mitra. "Recent advances in label-free optical, electrochemical, and electronic biosensors for glioma biomarkers." Biomicrofluidics 17, no. 1 (2023): 011502. http://dx.doi.org/10.1063/5.0135525.

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Gliomas are the most commonly occurring primary brain tumor with poor prognosis and high mortality rate. Currently, the diagnostic and monitoring options for glioma mainly revolve around imaging techniques, which often provide limited information and require supervisory expertise. Liquid biopsy is a great alternative or complementary monitoring protocol that can be implemented along with other standard diagnosis protocols. However, standard detection schemes for sampling and monitoring biomarkers in different biological fluids lack the necessary sensitivity and ability for real-time analysis.

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Kang, Min-Ji, Yeon-Woo Cho, and Tae-Hyung Kim. "Progress in Nano-Biosensors for Non-Invasive Monitoring of Stem Cell Differentiation." Biosensors 13, no. 5 (2023): 501. http://dx.doi.org/10.3390/bios13050501.

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Non-invasive, non-destructive, and label-free sensing techniques are required to monitor real-time stem cell differentiation. However, conventional analysis methods, such as immunocytochemistry, polymerase chain reaction, and Western blot, involve invasive processes and are complicated and time-consuming. Unlike traditional cellular sensing methods, electrochemical and optical sensing techniques allow non-invasive qualitative identification of cellular phenotypes and quantitative analysis of stem cell differentiation. In addition, various nano- and micromaterials with cell-friendly properties

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Awad, Atheer, Lucía Rodríguez-Pombo, Paula Esteiro Simón, et al. "Smartphone Biosensors for Non-Invasive Drug Monitoring in Saliva." Biosensors 15, no. 3 (2025): 163. https://doi.org/10.3390/bios15030163.

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In recent years, biosensors have emerged as a promising solution for therapeutic drug monitoring (TDM), offering automated systems for rapid chemical analyses with minimal pre-treatment requirements. The use of saliva as a biological sample matrix offers distinct advantages, including non-invasiveness, cost-effectiveness, and reduced susceptibility to fluid intake fluctuations compared to alternative methods. The aim of this study was to explore and compare two types of low-cost biosensors, namely, the colourimetric and electrochemical methodologies, for quantifying paracetamol (acetaminophen)

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Chen, Shiue-Luen, Chong-You Chen, Jason Chia-Hsun Hsieh, et al. "Graphene Oxide-Based Biosensors for Liquid Biopsies in Cancer Diagnosis." Nanomaterials 9, no. 12 (2019): 1725. http://dx.doi.org/10.3390/nano9121725.

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Liquid biopsies use blood or urine as test samples, which are able to be continuously collected in a non-invasive manner. The analysis of cancer-related biomarkers such as circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), microRNA, and exosomes provides important information in early cancer diagnosis, tumor metastasis detection, and postoperative recurrence monitoring assist with clinical diagnosis. However, low concentrations of some tumor markers, such as CTCs, ctDNA, and microRNA, in the blood limit its applications in clinical detection and analysis. Nanomaterials based on gra

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Bellassai, Noemi, Roberta D'Agata, vanessa Jungbluth, and Giuseppe Spoto. "Surface Plasmon Resonance for Biomarker Detection: Advances in Non-invasive Cancer Diagnosis." Frontiers in Chemistry 7 (August 9, 2019): 570. https://doi.org/10.3389/fchem.2019.00570.

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Biomarker-based cancer analysis has great potential to lead to a better understanding of disease at the molecular level and to improve early diagnosis and monitoring. Unlike conventional tissue biopsy, liquid biopsy allows the detection of a large variety of circulating biomarkers, such as microRNA (miRNA), exosomes, circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), and proteins, in an easily accessible and minimally invasive way. In this review, we describe and evaluate the relevance and applicability of surface plasmon resonance (SPR) and localized SPR (LSPR)-based platforms for

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Vetrivel, Cittrarasu, Ganesan Sivarasan, Kaliannan Durairaj, et al. "MoS2-ZnO Nanocomposite Mediated Immunosensor for Non-Invasive Electrochemical Detection of IL8 Oral Tumor Biomarker." Diagnostics 13, no. 8 (2023): 1464. http://dx.doi.org/10.3390/diagnostics13081464.

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In order to support biomolecule attachment, an effective electrochemical transducer matrix for biosensing devices needs to have many specialized properties, including quick electron transfer, stability, high surface area, biocompatibility, and the presence of particular functional groups. Enzyme-linked immunosorbent assays, gel electrophoresis, mass spectrometry, fluorescence spectroscopy, and surface-enhanced Raman spectroscopy are common techniques used to assess biomarkers. Even though these techniques provide precise and trustworthy results, they cannot replace clinical applications becaus

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Hussain, Nadia Muhammad, Bilal Amin, Martin O’Halloran, and Adnan Elahi. "Development and Characterization of Interstitial-Fluid-Mimicking Solutions for Pre-Clinical Assessment of Hypoxia." Diagnostics 13, no. 19 (2023): 3125. http://dx.doi.org/10.3390/diagnostics13193125.

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Asphyxia, a leading cause of illness and death in newborns, can be improved by early detection and management. Arterial blood gas (ABG) analysis is commonly used to diagnose and manage asphyxia, but it is invasive and carries risks. Dermal interstitial fluid (ISF) is an alternative physiological fluid that can provide valuable information about a person’s health. ISF is more sensitive to severe hypoxia and metabolic disorders compared to blood, making it an attractive option for minimally invasive asphyxia detection using biosensors. However, obtaining ISF samples from humans is challenging du

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Zhang, Tongrui. "Application and Exploration of Biosensors for Cancer Liquid Biopsy and Artificial Intelligence-Assisted Data Analysis." MATEC Web of Conferences 410 (2025): 04021. https://doi.org/10.1051/matecconf/202541004021.

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Cancer is one of the diseases with the highest mortality rate in the world, and its early diagnosis and precise treatment have always been the focus of medical research. Traditional detection technology has limitations such as trauma and difficulty in dynamic monitoring, while biosensors combined with liquid biopsy as an emerging non-invasive detection technology can detect tumor-related markers in body fluids and convert them into quantifiable data through biosensors. However, liquid biopsy still faces challenges such as low marker concentration, weak signals, and complex data analysis. There

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Messina, Leonardo, and Maria Teresa Giardi. "Recent Status on Lactate Monitoring in Sweat Using Biosensors: Can This Approach Be an Alternative to Blood Detection?" Biosensors 15, no. 1 (2024): 3. https://doi.org/10.3390/bios15010003.

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Recent studies have shown that lactate is a molecule that plays an indispensable role in various physiological cellular processes, such as energy metabolism and signal transductions related to immune and inflammatory processes. For these reasons, interest in its detection using biosensors for non-invasive analyses of sweat during sports activity and in clinical reasons assessments has increased. In this minireview, an in-depth study was carried out on biosensors that exploited using electrochemical methods and innovative nanomaterials for lactate detection in sweat. This detection of lactate b

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Lang, Yiqian. "Application performance of silicon-based different biosensors." Highlights in Science, Engineering and Technology 99 (June 18, 2024): 189–93. http://dx.doi.org/10.54097/gpddvh19.

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Biosensor is the equipment for biomolecules detection and it has been widely applied in a diverse of different fields such as disease diagnosis and harmful substance detection. Introducing different types of functional materials into biosensor can give it unique characteristics such as high sensitivity and high selectivity. Silicon, carbon nanotubes, gold, graphene and platinum are all trending materials for designing biosensors. Silicon is a non-toxic material that is commonly used as an element for biosensors. Different types of silicon-based functional materials have also been developed, wh

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Gao, Minjia, Tian Qiang, Yangchuan Ma, Junge Liang, and Yanfeng Jiang. "RFID-Based Microwave Biosensor for Non-Contact Detection of Glucose Solution." Biosensors 11, no. 12 (2021): 480. http://dx.doi.org/10.3390/bios11120480.

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Due to the increasing number of diabetic patients, early monitoring of glucose levels is particularly important; therefore, glucose biosensors have attracted enormous attention from researchers. In this paper, we propose a glucose microwave biosensor based on RFID and achieve a non-contact measurement of the concentration of glucose solutions. The Reader is a complementary split-ring resonator (CSRR), and the Tag is comprised of a squared spiral capacitor (SSC). A polydimethylsiloxane microfluidic quantitative cavity with a volume of 1.56 μL is integrated on the Tag to ensure that the glucose

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Gao, Wei. "(Invited) Skin-Interfaced Wearable Biosensors." ECS Meeting Abstracts MA2023-02, no. 63 (2023): 2978. http://dx.doi.org/10.1149/ma2023-02632978mtgabs.

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The rising research interest in personalized medicine promises to revolutionize traditional medical practices. This presents a tremendous opportunity for developing wearable devices toward predictive analytics and treatment. In this talk, I will introduce our efforts in developing wearable biosensors for non-invasive molecular analysis. Such wearables can autonomously access sweat across activities and continuously measure a broad spectrum of analytes including metabolites, nutrients, hormones, and drugs. Laser-engraving and inkjet printing are used to manufacture these nanomaterials-based bio

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Jamshidnejad-Tosaramandani, Tahereh, Soheila Kashanian, Kobra Omidfar, and Helgi B. Schiöth. "The Role of Nanomaterials in the Wearable Electrochemical Glucose Biosensors for Diabetes Management." Biosensors 15, no. 7 (2025): 451. https://doi.org/10.3390/bios15070451.

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The increasing prevalence of diabetes mellitus necessitates the development of advanced glucose-monitoring systems that are non-invasive, reliable, and capable of real-time analysis. Wearable electrochemical biosensors have emerged as promising tools for continuous glucose monitoring (CGM), particularly through sweat-based platforms. This review highlights recent advancements in enzymatic and non-enzymatic wearable biosensors, with a specific focus on the pivotal role of nanomaterials in enhancing sensor performance. In enzymatic sensors, nanomaterials serve as high-surface-area supports for g

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Delatour, Eva, Christophe Pagnout, Marie L. Zaffino, and Jérôme F. L. Duval. "Comparative Analysis of Cell Metabolic Activity Sensing by Escherichia coli rrnB P1-lux and Cd Responsive-Lux Biosensors: Time-Resolved Experiments and Mechanistic Modelling." Biosensors 12, no. 9 (2022): 763. http://dx.doi.org/10.3390/bios12090763.

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Whole-cell bacterial sensors are used in medical/environmental applications to detect chemicals, and to assess medium toxicity or stress. Non-specific constitutive biosensors generally serve the latter purpose, whereas chemical detection is performed with biosensors involving a specific chemical-inducible promoter. Herein, we show that functioning principles of specific and non-specific whole-cell biosensors are not exclusive as both can probe modulations of cell metabolic activity under stressing conditions. The demonstration is based on (i) time-resolved measurements of bioluminescence produ

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Bamgboje, David, Iasonas Christoulakis, Ioannis Smanis, et al. "Continuous Non-Invasive Glucose Monitoring via Contact Lenses: Current Approaches and Future Perspectives." Biosensors 11, no. 6 (2021): 189. http://dx.doi.org/10.3390/bios11060189.

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Diabetes mellitus (DM) is a chronic disease that must be carefully managed to prevent serious complications such as cardiovascular disease, retinopathy, nephropathy and neuropathy. Self-monitoring of blood glucose is a crucial tool for managing diabetes and, at present, all relevant procedures are invasive while they only provide periodic measurements. The pain and measurement intermittency associated with invasive techniques resulted in the exploration of painless, continuous, and non-invasive techniques of glucose measurement that would facilitate intensive management. The focus of this revi

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Ashrafi, Sýs, Sedláčková, et al. "Application of the Enzymatic Electrochemical Biosensors for Monitoring Non-Competitive Inhibition of Enzyme Activity by Heavy Metals." Sensors 19, no. 13 (2019): 2939. http://dx.doi.org/10.3390/s19132939.

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The inhibition effect of the selected heavy metals (Ag+, Cd2+, Cu2+, and Hg2+) on glucose oxidase (GOx) enzyme from Aspergillus niger (EC 1.1.3.4.) was studied using a new amperometric biosensor with an electrochemical transducer based on a glassy carbon electrode (GCE) covered with a thin layer of multi-wall carbon nanotubes (MWCNTs) incorporated with ruthenium(IV) oxide as a redox mediator. Direct adsorption of multi-wall carbon nanotubes (MWCNTs) and subsequent covering with Nafion® layer was used for immobilization of GOx. The analytical figures of merit of the developed glucose (Glc) bios

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Li, Chunmei, Bo Che, and Linhong Deng. "Electrochemical Biosensors Based on Carbon Nanomaterials for Diagnosis of Human Respiratory Diseases." Biosensors 13, no. 1 (2022): 12. http://dx.doi.org/10.3390/bios13010012.

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In recent years, respiratory diseases have increasingly become a global concern, largely due to the outbreak of Coronavirus Disease 2019 (COVID-19). This inevitably causes great attention to be given to the development of highly efficient and minimal or non-invasive methods for the diagnosis of respiratory diseases. And electrochemical biosensors based on carbon nanomaterials show great potential in fulfilling the requirement, not only because of the superior performance of electrochemical analysis, but also given the excellent properties of the carbon nanomaterials. In this paper, we review t

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Mummareddy, Sai, Stuti Pradhan, Ashwin Narasimhan, and Arutselvan Natarajan. "On Demand Biosensors for Early Diagnosis of Cancer and Immune Checkpoints Blockade Therapy Monitoring from Liquid Biopsy." Biosensors 11, no. 12 (2021): 500. http://dx.doi.org/10.3390/bios11120500.

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Recently, considerable interest has emerged in the development of biosensors to detect biomarkers and immune checkpoints to identify and measure cancer through liquid biopsies. The detection of cancer biomarkers from a small volume of blood is relatively fast compared to the gold standard of tissue biopsies. Traditional immuno-histochemistry (IHC) requires tissue samples obtained using invasive procedures and specific expertise as well as sophisticated instruments. Furthermore, the turnaround for IHC assays is usually several days. To overcome these challenges, on-demand biosensor-based assays

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Gao, Wei. "(Invited) Skin-Interfaced Wearable Sweat Biosensors." ECS Meeting Abstracts MA2024-01, no. 50 (2024): 2737. http://dx.doi.org/10.1149/ma2024-01502737mtgabs.

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The rising research interest in personalized medicine promises to revolutionize traditional medical practices. This presents a tremendous opportunity for developing wearable devices toward predictive analytics and treatment. In this talk, I will introduce our efforts in developing wearable biosensors for non-invasive molecular analysis. Such wearables can autonomously access body fluids (e.g., human sweat) across the activities and continuously measure a broad spectrum of analytes including metabolites, nutrients, hormones, proteins, and drugs. I will highlight our recent works in the design o

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Gao, Wei. "(Invited) Skin-Interfaced Wearable Electrochemical Biosensors." ECS Meeting Abstracts MA2025-01, no. 60 (2025): 2833. https://doi.org/10.1149/ma2025-01602833mtgabs.

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The growing interest in personalized medicine is set to transform conventional healthcare, offering new avenues for predictive analytics and tailored treatment approaches. In this talk, I will present our advancements in developing wearable electrochemical biosensors for non-invasive molecular analysis. These wearables autonomously access and sample body fluids, such as sweat, wound exudate, and exhaled breath condensate, continuously monitoring a wide array of analytes—including metabolites, nutrients, hormones, proteins, and drugs—during various daily activities. To enable large-scale, cost-

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Wasilewski, Tomasz, Bartosz Szulczyński, Dominik Dobrzyniewski, Weronika Jakubaszek, Jacek Gębicki, and Wojciech Kamysz. "Development and Assessment of Regeneration Methods for Peptide-Based QCM Biosensors in VOCs Analysis Applications." Biosensors 12, no. 5 (2022): 309. http://dx.doi.org/10.3390/bios12050309.

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Cleaning a quartz crystal microbalance (QCM) plays a crucial role in the regeneration of its biosensors for reuse. Imprecise removal of a receptor layer from a transducer’s surface can lead to unsteady operation during measurements. This article compares three approaches to regeneration of the piezoelectric transducers using the electrochemical, oxygen plasma and Piranha solution methods. Optimization of the cleaning method allowed for evaluation of the influence of cleaning on the surface of regenerated biosensors. The effectiveness of cleaning the QCM transducers with a receptor layer in the

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Benjamin, Stephen Rathinaraj, Fábio de Lima, Paulo Iury Gomes Nunes, Rosa Fireman Dutra, Geanne Matos de Andrade, and Reinaldo B. Oriá. "Advanced Biosensing Technologies: Leading Innovations in Alzheimer’s Disease Diagnosis." Chemosensors 13, no. 6 (2025): 220. https://doi.org/10.3390/chemosensors13060220.

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Diagnosing Alzheimer’s disease (AD) remains a significant challenge due to its multifactorial nature and the limitations of traditional diagnostic methods, such as clinical assessments and neuroimaging, which often lack the specificity and sensitivity required for early detection. The urgent need for innovative diagnostic tools is further underscored by the potential of early intervention to improve treatment outcomes and slow disease progression. Recent advancements in biosensing technologies offer promising solutions for precise and non-invasive AD detection. Electrochemical and optical bios

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Bari, Saif Mohammad Ishraq, Faria Binte Hossain, and Gergana G. Nestorova. "Advances in Biosensors Technology for Detection and Characterization of Extracellular Vesicles." Sensors 21, no. 22 (2021): 7645. http://dx.doi.org/10.3390/s21227645.

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Exosomes are extracellular vehicles (EVs) that encapsulate genomic and proteomic material from the cell of origin that can be used as biomarkers for non-invasive disease diagnostics in point of care settings. The efficient and accurate detection, quantification, and molecular profiling of exosomes are crucial for the accurate identification of disease biomarkers. Conventional isolation methods, while well-established, provide the co-purification of proteins and other types of EVs. Exosome purification, characterization, and OMICS analysis are performed separately, which increases the complexit

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Bhardwaj, Tanu, Lakshmi Ramana, and Tarun Sharma. "Current Advancements and Future Road Map to Develop ASSURED Microfluidic Biosensors for Infectious and Non-Infectious Diseases." Biosensors 12, no. 5 (2022): 357. http://dx.doi.org/10.3390/bios12050357.

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Better diagnostics are always essential for the treatment and prevention of a disease. Existing technologies for detecting infectious and non-infectious diseases are mostly tedious, expensive, and do not meet the World Health Organization’s (WHO) ASSURED (affordable, sensitive, specific, user-friendly, rapid and robust, equipment-free, and deliverable to end user) criteria. Hence, more accurate, sensitive, and faster diagnostic technologies that meet the ASSURED criteria are highly required for timely and evidenced-based treatment. Presently, the diagnostics industry is finding interest in mic

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Namita Sharma and Sudha Srivastava. "Transforming Pancreatic Cancer Diagnosis: Conventional Methods, Challenges, and Future Innovations." Exon 2, no. 2 (2025): 86–111. https://doi.org/10.69936/en06y0025.

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Pancreatic ductal adenocarcinoma (PDAC) is a well-known neoplasm that currently ranks seventh in cancer-related deaths worldwide and may occupy the second position by 2030. This cancer remains undetected until it reaches an advanced stage due to inaccessible positioning of the gland, delayed appearance of symptoms, and lack of specific biomarkers. Consequently, this results in low survival rates and high mortality. Here, in this review, we evaluate the necessity of screening and early diagnosis of pancreatic cancer. We also discussed various diagnostic methods for diagnosis and current biomark

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Ameh, Sunday, Nkechi Asogwa, Taiwo Awojulu, Kelechi Asogwa, and Joseph Ezeani. "Photonics‑Fueled Profiling: Label‑Free Surface Plasmon Resonance and Localized Surface Plasmon Resonance Biosensors for Multiplexed Adipokine Detection in Obesity." International Journal of Future Engineering Innovations 1, no. 3 (2024): 30–41. https://doi.org/10.54660/ijfei.2024.1.3.30-41.

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Obesity is a major global health concern linked to chronic inflammation, insulin resistance, and increased risk of metabolic diseases such as type 2 diabetes and cardiovascular disorders. Adipokines, a group of signaling proteins secreted by adipose tissue, play critical roles in regulating metabolic and inflammatory pathways. Accurate monitoring of adipokine levels can provide valuable insight into the onset and progression of obesity-related complications. However, traditional detection methods such as ELISA face limitations in sensitivity, throughput, and real-time analysis. Surface plasmon

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Du, Kun, Qinlong Zeng, Mingjun Jiang, Zhiqing Hu, Miaojin Zhou, and Kun Xia. "CRISPR/Cas12a-Based Biosensing: Advances in Mechanisms and Applications for Nucleic Acid Detection." Biosensors 15, no. 6 (2025): 360. https://doi.org/10.3390/bios15060360.

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Nucleic acid detection technology is crucial for molecular diagnosis. The advent of CRISPR/Cas12a-based nucleic acid detection has considerably broadened its scope, from the identification of infectious disease-causing microorganisms to the detection of disease-associated biomarkers. This innovative system capitalizes on the non-specific single-strand cleavage activity of Cas12a upon target DNA recognition. By employing a fluorescent probe in the form of a single-stranded DNA/RNA, this technology enables the observation of fluorescence changes resulting from nonspecific cleavage, thereby facil

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Shoute, Lian C. T., Carmen L. Charlton, Jamil N. Kanji, Shawn Babiuk, Lorne Babiuk, and Jie Chen. "Faradaic Impedimetric Immunosensor for Label-Free Point-of-Care Detection of COVID-19 Antibodies Using Gold-Interdigitated Electrode Array." Biosensors 14, no. 1 (2023): 6. http://dx.doi.org/10.3390/bios14010006.

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Label-free electrochemical biosensors have many desirable characteristics in terms of miniaturization, scalability, digitization, and other attributes associated with point-of-care (POC) applications. In the era of COVID-19 and pandemic preparedness, further development of such biosensors will be immensely beneficial for rapid testing and disease management. Label-free electrochemical biosensors often employ [Fe(CN)6]−3/4 redox probes to detect low-concentration target analytes as they dramatically enhance sensitivity. However, such Faradaic-based sensors are reported to experience baseline si

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Lee, DaeSik. "(Invited) Multi-Modal Solid-State Gas Sensors-Based Breath Analysis System with Convolutional Neural Network (CNN) for Early Detection of Lung Cancer." ECS Meeting Abstracts MA2024-01, no. 33 (2024): 1615. http://dx.doi.org/10.1149/ma2024-01331615mtgabs.

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Currently, digital healthcare technologies based on Internet of Things (IOT) are emerging, and the market for digital healthcare was estimated to be 151.5 billion dollars by 2020. Among the digital healthcare technologies, disease diagnosis is attracting maximum attention. Traditional diagnostic methods, such as radiology and human biological material analysis, have limitations of long study time, high cost, radiation exposure, and pain. Therefore, non-invasive diagnostics methods, for early diagnosis of specific diseases and personal healthcare management, have attracted attention. Breath sen

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Colapietro, Paola, Giuseppe Brunetti, Carlotta Panciera, Aurora Elicio, and Caterina Ciminelli. "Shining the Path of Precision Diagnostic: Advancements in Photonic Sensors for Liquid Biopsy." Biosensors 15, no. 8 (2025): 473. https://doi.org/10.3390/bios15080473.

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Liquid biopsy (LB) has gained attention as a valuable approach for cancer diagnostics, providing a minimally invasive option compared to conventional tissue biopsies and helping to overcome issues related to patient discomfort and procedural invasiveness. Recent advances in biosensor technologies, particularly photonic sensors, have improved the accuracy, speed, and real-time capabilities for detecting circulating biomarkers in biological fluids. Incorporating these tools into clinical practice facilitates more informed therapeutic choices and contributes to tailoring treatments to individual

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Golfinopoulou, Rebecca, Kyriaki Hatziagapiou, Sophie Mavrikou, and Spyridon Kintzios. "Unveiling Colorectal Cancer Biomarkers: Harnessing Biosensor Technology for Volatile Organic Compound Detection." Sensors 24, no. 14 (2024): 4712. http://dx.doi.org/10.3390/s24144712.

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Conventional screening options for colorectal cancer (CRC) detection are mainly direct visualization and invasive methods including colonoscopy and flexible sigmoidoscopy, which must be performed in a clinical setting and may be linked to adverse effects for some patients. Non-invasive CRC diagnostic tests such as computed tomography colonography and stool tests are either too costly or less reliable than invasive ones. On the other hand, volatile organic compounds (VOCs) are potentially ideal non-invasive biomarkers for CRC detection and monitoring. The present review is a comprehensive prese

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Franco, Fabiane Fantinelli, Richard A. Hogg, and Libu Manjakkal. "Cu2O-Based Electrochemical Biosensor for Non-Invasive and Portable Glucose Detection." Biosensors 12, no. 3 (2022): 174. http://dx.doi.org/10.3390/bios12030174.

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Electrochemical voltammetric sensors are some of the most promising types of sensors for monitoring various physiological analytes due to their implementation as non-invasive and portable devices. Advantages in reduced analysis time, cost-effectiveness, selective sensing, and simple techniques with low-powered circuits distinguish voltammetric sensors from other methods. In this work, we developed a Cu2O-based non-enzymatic portable glucose sensor on a graphene paste printed on cellulose cloth. The electron transfer of Cu2O in a NaOH alkaline medium and sweat equivalent solution at very low po

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Divya Midhunchakkaravarthy, G Muni Nagamani, and V Lakshman Narayana. "An Iterative Statistical Analytical Review of Multi-Scale Deep Learning, Machine Learning, and Biosensor Technologies for Early Colorectal Cancer Detection." Bioscan 20, Supplement 2 (2025): 316–29. https://doi.org/10.63001/tbs.2025.v20.i02.s2.pp316-329.

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Colorectal cancer (CRC) is one of the major causes of cancer-related deaths globally, wherein early detection is key to improved survival. The traditional methods of diagnosis such as colonoscopy and histopathological analysis are subject to limitations imposed by subjective interpretations, high costs, and invasive methods. Although AI-based methods appeared quite promising for CRC detection, most reviews conducted so far lack a broad, multi-modal perspective on the combination of deep learning (DL), machine learning (ML), biosensor technologies, and multi-omics biomarker integration. Further

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Pour, Seyedeh Rojin Shariati, Donato Calabria, Afsaneh Emamiamin, et al. "Electrochemical vs. Optical Biosensors for Point-of-Care Applications: A Critical Review." Chemosensors 11, no. 10 (2023): 546. http://dx.doi.org/10.3390/chemosensors11100546.

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Analytical chemistry applied to medical and diagnostic analysis has recently focused on the development of cost-effective biosensors able to monitor the health status or to assess the level of specific biomarkers that can be indicative of several diseases. The improvement of technologies relating to the possibility of the non-invasive sampling of biological fluids, as well as sensors for the detection of analytical signals and the computational capabilities of the systems routinely employed in everyday life (e.g., smartphones, computers, etc.), makes the complete integration of self-standing a

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Alrebaish, Abdulelah S., Layla O. Alnami, Joud M. Alshraim, et al. "Evaluation of Non-Faradaic Impedimetric Parameters for IL-8 Detection Using Gold Interdigitated Electrode-Based Biosensors: Towards Early Detection of Newborn Disability." Micromachines 16, no. 4 (2025): 395. https://doi.org/10.3390/mi16040395.

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Interleukin-8 (IL-8) is a critical biomarker associated with inflammation and disability in both adults and newborns. Conventional detection methods are often labor-intensive, time-consuming, and require highly trained personnel. Non-Faradaic impedimetric biosensors offer a label-free, rapid, and direct approach for IL-8 detection. While previous studies have primarily focused on capacitance and phase changes, the potential of other impedimetric parameters remains underexplored. In this study, a gold interdigitated electrode (Au-IDE)-based non-Faradaic biosensor was developed for IL-8 detectio

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Alfinito, Eleonora, Matteo Beccaria, and Mariangela Ciccarese. "Biosensing Cytokine IL-6: A Comparative Analysis of Natural and Synthetic Receptors." Biosensors 10, no. 9 (2020): 106. http://dx.doi.org/10.3390/bios10090106.

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Cytokines are a family of proteins which play a major role in the regulation of the immune system and the development of several diseases, from rheumatoid arthritis to cancer and, more recently, COVID-19. Therefore, many efforts are currently being developed to improve therapy and diagnosis, as well as to produce inhibitory drugs and biosensors for a rapid, minimally invasive, and effective detection. In this regard, even more efficient cytokine receptors are under investigation. In this paper we analyze a set of IL-6 cytokine receptors, investigating their topological features by means of a t

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Ramachandran, Lohit, Farah Abul Rub, Amro Hajja, et al. "Biosensing of Alpha-Fetoprotein: A Key Direction toward the Early Detection and Management of Hepatocellular Carcinoma." Biosensors 14, no. 5 (2024): 235. http://dx.doi.org/10.3390/bios14050235.

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Hepatocellular carcinoma (HCC) is currently one of the most prevalent cancers worldwide. Associated risk factors include, but are not limited to, cirrhosis and underlying liver diseases, including chronic hepatitis B or C infections, excessive alcohol consumption, nonalcoholic fatty liver disease (NAFLD), and exposure to chemical carcinogens. It is crucial to detect this disease early on before it metastasizes to adjoining parts of the body, worsening the prognosis. Serum biomarkers have proven to be a more accurate diagnostic tool compared to imaging. Among various markers such as nucleic aci

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Ullah, Sadia Fida, Geisianny Moreira, Shoumen Palit Austin Datta, Eric McLamore, and Diana Vanegas. "An Experimental Framework for Developing Point-of-Need Biosensors: Connecting Bio-Layer Interferometry and Electrochemical Impedance Spectroscopy." Biosensors 12, no. 11 (2022): 938. http://dx.doi.org/10.3390/bios12110938.

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Biolayer interferometry (BLI) is a well-established laboratory technique for studying biomolecular interactions important for applications such as drug development. Currently, there are interesting opportunities for expanding the use of BLI in other fields, including the development of rapid diagnostic tools. To date, there are no detailed frameworks for implementing BLI in target-recognition studies that are pivotal for developing point-of-need biosensors. Here, we attempt to bridge these domains by providing a framework that connects output(s) of molecular interaction studies with key perfor

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Ghorbanizamani, Faezeh, Hichem Moulahoum, Emine Guler Celik, et al. "Design of Polymeric Surfaces as Platforms for Streamlined Cancer Diagnostics in Liquid Biopsies." Biosensors 13, no. 3 (2023): 400. http://dx.doi.org/10.3390/bios13030400.

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Minimally invasive approaches for cancer diagnosis are an integral step in the quest to improve cancer survival. Liquid biopsies such as blood samples are matrices explored to extract valuable information about the tumor and its state through various indicators, such as proteins, peptides, tumor DNA, or circulating tumor cells. Although these markers are scarce, making their isolation and detection in complex matrices challenging, the development in polymer chemistry producing interesting structures, including molecularly imprinted polymers, branched polymers, nanopolymer composites, and hybri

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Bilbao, Emanuel, Octavio Garate, Theo Rodríguez Campos, et al. "Electrochemical Sweat Sensors." Chemosensors 11, no. 4 (2023): 244. http://dx.doi.org/10.3390/chemosensors11040244.

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Sweat analysis by means of minimally invasive wearable sensors is considered a potentially disruptive method for assessing clinical parameters, with exciting applications in early medical diagnostics and high-performance sports. Electrochemical sensors and biosensors are especially attractive because of the possibility of the electronic integration of wearable devices. In this article, we review several aspects regarding the potentialities and present limitations of electrochemical sweat (bio)sensors, including: the main target analytes and their relationships with clinical conditions; most us

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Oldak, Lukasz, Sylwia Chludzinska-Kasperuk, Patrycja Milewska, Kamil Grubczak, Joanna Reszec, and Ewa Gorodkiewicz. "Laminin-5, Fibronectin, and Type IV Collagen as Potential Biomarkers of Brain Glioma Malignancy." Biomedicines 10, no. 9 (2022): 2290. http://dx.doi.org/10.3390/biomedicines10092290.

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The presented work is based on the quantification of LN-5, FN, and COL IV in blood plasma as potential biomarkers in patients diagnosed with glioma in grades G1 to G4. The obtained concentration results were compared with the protein content in the control group, which consisted of smokers of different ages. The obtained results were statistically analysed and interpreted based on the available clinical description. Quantitative determinations of LN-5, FN, and COL IV were performed with the use of SPRi biosensors specific to the tested proteins. Comparing groups K and G4, as well as G2 and G4,

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Chellamani, Narmatha, Saleh Ali Albelwi, Manimurugan Shanmuganathan, Palanisamy Amirthalingam, and Anand Paul. "Diabetes: Non-Invasive Blood Glucose Monitoring Using Federated Learning with Biosensor Signals." Biosensors 15, no. 4 (2025): 255. https://doi.org/10.3390/bios15040255.

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Diabetes is a growing global health concern, affecting millions and leading to severe complications if not properly managed. The primary challenge in diabetes management is maintaining blood glucose levels (BGLs) within a safe range to prevent complications such as renal failure, cardiovascular disease, and neuropathy. Traditional methods, such as finger-prick testing, often result in low patient adherence due to discomfort, invasiveness, and inconvenience. Consequently, there is an increasing need for non-invasive techniques that provide accurate BGL measurements. Photoplethysmography (PPG),

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Lee, Minhyuk, Seungjae Kang, Sungjee Kim, and Nokyoung Park. "Advances and Trends in miRNA Analysis Using DNAzyme-Based Biosensors." Biosensors 13, no. 9 (2023): 856. http://dx.doi.org/10.3390/bios13090856.

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miRNAs are endogenous small, non-coding RNA molecules that function in post-transcriptional regulation of gene expression. Because miRNA plays a pivotal role in maintaining the intracellular environment, and abnormal expression has been found in many cancer diseases, detection of miRNA as a biomarker is important for early diagnosis of disease and study of miRNA function. However, because miRNA is present in extremely low concentrations in cells and many types of miRNAs with similar sequences are mixed, traditional gene detection methods are not suitable for miRNA detection. Therefore, in orde

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