Academic literature on the topic 'Non invasive fetal ECG'
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Journal articles on the topic "Non invasive fetal ECG"
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Clifford, Gari D., Ikaro Silva, Joachim Behar, and George B. Moody. "Non-invasive fetal ECG analysis." Physiological Measurement 35, no. 8 (2014): 1521–36. http://dx.doi.org/10.1088/0967-3334/35/8/1521.
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曹, 雪. "Non-Invasive Fetal ECG Signal Extraction." Advances in Clinical Medicine 09, no. 04 (2019): 507–18. http://dx.doi.org/10.12677/acm.2019.94078.
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Taylor, Myles J. O., Matthew J. Thomas, Mark J. Smith, et al. "Non-invasive intrapartum fetal ECG: preliminary report." BJOG: An International Journal of Obstetrics & Gynaecology 112, no. 8 (2005): 1016–21. http://dx.doi.org/10.1111/j.1471-0528.2005.00643.x.
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Shi, Xintong, Kohei Yamamoto, Tomoaki Ohtsuki, Yutaka Matsui, and Kazunari Owada. "Unsupervised Learning-Based Non-Invasive Fetal ECG Muti-Level Signal Quality Assessment." Bioengineering 10, no. 1 (2023): 66. http://dx.doi.org/10.3390/bioengineering10010066.
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Objective: To monitor fetal health and growth, fetal heart rate is a critical indicator. The non-invasive fetal electrocardiogram is a widely employed measurement for fetal heart rate estimation, which is extracted from the electrodes placed on the surface of the maternal abdomen. The qualities of the fetal ECG recordings, however, are frequently affected by the noises from various interference sources. In general, the fetal heart rate estimates are unreliable when low-quality fetal ECG signals are used for fetal heart rate estimation, which makes accurate fetal heart rate estimation a challenging task. So, the signal quality assessment for the fetal ECG records is an essential step before fetal heart rate estimation. In other words, some low-quality fetal ECG signal segments are supposed to be detected and removed by utilizing signal quality assessment, so as to improve the accuracy of fetal heart rate estimation. A few supervised learning-based fetal ECG signal quality assessment approaches have been introduced and shown to accurately classify high- and low-quality fetal ECG signal segments, but large fetal ECG datasets with quality annotation are required in these methods. Yet, the labeled fetal ECG datasets are limited. Proposed methods: An unsupervised learning-based multi-level fetal ECG signal quality assessment approach is proposed in this paper for identifying three levels of fetal ECG signal quality. We extracted some features associated with signal quality, including entropy-based features, statistical features, and ECG signal quality indices. Additionally, an autoencoder-based feature is calculated, which is related to the reconstruction error of the spectrograms generated from fetal ECG signal segments. The high-, medium-, and low-quality fetal ECG signal segments are classified by inputting these features into a self-organizing map. Main results: The experimental results showed that our proposal achieved a weighted average F1-score of 90% in three-level fetal ECG signal quality classification. Moreover, with the acceptable removal of detected low-quality signal segments, the errors of fetal heart rate estimation were reduced to a certain extent.
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Behar, Joachim, Tingting Zhu, Julien Oster, et al. "Evaluation of the fetal QT interval using non-invasive fetal ECG technology." Physiological Measurement 37, no. 9 (2016): 1392–403. http://dx.doi.org/10.1088/0967-3334/37/9/1392.
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Karvounis, E. C., M. G. Tsipouras, C. Papaloukas, D. G. Tsalikakis, K. K. Naka, and D. I. Fotiadis. "A Non-invasive Methodology for Fetal Monitoring during Pregnancy." Methods of Information in Medicine 49, no. 03 (2010): 238–53. http://dx.doi.org/10.3414/me09-01-0041.
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Summary Objectives: This paper describes a methodology for the monitoring of the fetal cardiac health status during pregnancy, through the effective and non-invasive monitoring of the abdominal ECG signals (abdECG) of the mother. Methods: For this purpose, a three-stage methodology has been developed. In the first stage, the fetal heart rate (fHR) is extracted from the abdECG signals, using nonlinear analysis. Also, the eliminated ECG (eECG) is calculated, which is the abdECG after the maternal QRSs elimination. In the second stage, a blind source separation technique is applied to the eECG signals and the fetal ECG (fECG) is obtained. Finally, monitoring of the fetus is implemented using features extracted from the fHR and f ECG, such as the T/QRS ratio and the characterization of the fetal ST waveforms. Results: The methodology is evaluated using a dataset of simulated multichannel abdECG signals: 94.79% accuracy for fHR extraction, 92.49% accuracy in T/QRS ratio calculation and 79.87% in ST waveform classification. Conclusions: The novel non-invasive proposed methodology is advantageous since it offers automated identification of fHR and fECG and automated ST waveform analysis, exhibiting a high diagnostic accuracy.
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Noben, Lore, Sally-Ann Clur, Judith OEH van Laar, and Rik Vullings. "Prenatal diagnosis of a bundle branch block based on the fetal ECG." BMJ Case Reports 12, no. 7 (2019): e229998. http://dx.doi.org/10.1136/bcr-2019-229998.
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A non-invasive fetal ECG was performed on a 36-year-old pregnant woman at 24+6 weeks of gestation as part of ongoing clinical research. A paediatric cardiologist suspected an incomplete bundle branch block based on the averaged ECGs from the recording. The characteristic terminal R’ wave was present in multiple leads of the fetal ECGs. A fetal anomaly scan had been performed at 20 weeks of gestation and showed no abnormalities. An incomplete right bundle branch block was confirmed on an ECG recorded at the age of 2 years. This case shows the possibility of novel non-invasive fetal ECG technology as an adjunct to the diagnosis of fetal cardiac anomalies in the future.
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M, Nivitha, and Santhi C. "Non- Invasive Method of Fetal ECG Extraction Using Hilbert Transform." IJIREEICE 4, no. 2 (2016): 237–45. http://dx.doi.org/10.17148/ijireeice/ncaee.2016.48.
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Noorwali, Abdulfattah, Ameni Yengui, Kai鏰r Ammous, and Anis Ammous. "Design and Realization of Non Invasive Fetal ECG Monitoring System." Intelligent Automation & Soft Computing 32, no. 1 (2022): 455–66. http://dx.doi.org/10.32604/iasc.2022.020574.
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Behar, Joachim, Adam Wolfberg, Tingting Zhu, et al. "576: Evaluation of the fetal QT interval using non-invasive fetal ECG technology." American Journal of Obstetrics and Gynecology 210, no. 1 (2014): S283—S284. http://dx.doi.org/10.1016/j.ajog.2013.10.609.
Full textDissertations / Theses on the topic "Non invasive fetal ECG"
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Behar, Joachim. "Extraction of clinical information from the non-invasive fetal electrocardiogram." Thesis, University of Oxford, 2014. http://ora.ox.ac.uk/objects/uuid:94b866ff-dd57-4446-85ae-79dd6d983cac.
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Estimation of the fetal heart rate (FHR) has gained interest in the last century; low heart rate variability has been studied to identify intrauterine growth restricted fetuses (prepartum), and abnormal FHR patterns have been associated with fetal distress during delivery (intrapartum). Several monitoring techniques have been proposed for FHR estimation, including auscultation and Doppler ultrasound. This thesis focuses on the extraction of the non-invasive fetal electrocardiogram (NI-FECG) recorded from a limited set of abdominal sensors. The main challenge with NI-FECG extraction techniques is the low signal-to-noise ratio of the FECG signal on the abdominal mixture signal which consists of a dominant maternal ECG component, FECG and noise. However the NI-FECG offers many advantages over the alternative fetal monitoring techniques, the most important one being the opportunity to enable morphological analysis of the FECG which is vital for determining whether an observed FHR event is normal or pathological. In order to advance the field of NI-FECG signal processing, the development of standardised public databases and benchmarking of a number of published and novel algorithms was necessary. Databases were created depending on the application: FHR estimation with or without maternal chest lead reference or directed toward FECG morphology analysis. Moreover, a FECG simulator was developed in order to account for pathological cases or rare events which are often under-represented (or completely missing) in the existing databases. This simulator also serves as a tool for studying NI-FECG signal processing algorithms aimed at morphological analysis (which require underlying ground truth annotations). An accurate technique for the automatic estimation of the signal quality level was also developed, optimised and thoroughly tested on pathological cases. Such a technique is mandatory for any clinical applications of FECG analysis as an external confidence index of both the input signals and the analysis outputs. Finally, a Bayesian filtering approach was implemented in order to address the NI-FECG morphology analysis problem. It was shown, for the first time, that the NI-FECG can allow accurate estimation of the fetal QT interval, which opens the way for new clinical studies on the development of the fetus during the pregnancy.
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DESSÌ, ALESSIA. "Algorithms and systems for home telemonitoring in biomedical applications." Doctoral thesis, Università degli Studi di Cagliari, 2015. http://hdl.handle.net/11584/266603.
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During the past decades, the interest of the healthcare community shifted from the simple treatment of the diseases towards the prevention and maintenance of a healthy lifestyle. This approach is associated to a reduced cost for the Health Systems, having to face the constantly increased expenditures due to the reduced mortality for chronical diseases and to the progressive population ageing. Nevertheless, the high costs related to hospitalization of patients for monitoring procedures that could be better performed at home hamper the full implementation of this approach in a traditional way. Information and Communication Technology can provide a solution to implement a care model closer to the patient, crossing the physical boundaries of the hospitals and thus allowing to reach also those patients that, for a geographical or social condition, could not access the health services as other luckier subjects. This is the case of telemonitoring systems, whose aim is that of providing monitoring services for some health-related parameters at a distance, by means of custom-designed electronic devices. In this thesis, the specific issues associated to two telemonitoring applications are presented, along with the proposed solutions and the achieved results.
The first telemonitoring application considered is the fetal electrocardiography. Non-invasive fetal electrocardiography is the recording of the fetal heart electrical activity using electrodes placed on the maternal abdomen. It can provide important diagnostic parameters, such as the beat-to-beat heart rate variability, whose recurring analysis would be useful in assessing and monitoring fetal health during pregnancy. Long term electrocardiographic monitoring is sustained by the absence of any collateral effects for both the mother and the fetus.
This application has been tackled from several perspectives, mainly acquisition and processing. From the acquisition viewpoint a study on different skin treatments, disposable commercial electrodes and textile electrodes has been performed with the aim of improving the signal acquisition quality, while simplifying the measurement setup. From the processing viewpoint, different algorithms have been developed to allow extracting the fetal ECG heart rate, starting from an on-line ICA algorithm or exploiting a subtractive approach to work on recordings acquired with a reduced number of electrodes. The latter, took part to the international "Physionet/Computing in Cardiology Challenge" in 2013 entering into the top ten best-performing open-source algorithms. The improved version of this algorithm is also presented, which would mark the 5th and 4th position in the final ranking related to the fetal heart rate and fetal RR interval measurements performance, reserved to the open-source challenge entries, taking into account both official and unofficial entrants. The research in this field has been carried out in collaboration with the Pediatric Cardiology Unit of the Hospital G. Brotzu in Cagliari, for the acquisition of non-invasive fetal ECG signals from pregnant voluntary patients.
The second telemonitoring application considered is the telerehabilitation of the hand. The execution of rehabilitation exercises has been proven to be effective in recovering hand functionality in a wide variety of invalidating diseases, but the lack of standardization and continuous medical control cause the patients neglecting this therapeutic procedures. Telemonitoring the rehabilitation sessions would allow the physician to closely follow the patients' progresses and compliance to the prescribed adapted exercises.
This application leads to the development of a sensorized telerehabilitation system for the execution and objective monitoring of therapeutic exercises at the patients' home and of the telemedicine infrastructure that give the physician the opportunity to monitor patients' progresses through parameters summarizing the patients' performance. The proposed non-CE marked medical device, patent pending, underwent a
clinical trial, reviewed and approved by the Italian Public Health Department, involving 20 patients with Rheumatoid Arthritis and 20 with Systemic Sclerosis randomly assigned to the experimental or the control arm, enrolled for 12 weeks in a home rehabilitation program. The trial, carried out with the collaboration of the Rheumatology Department of the Policlinico Universitario of Cagliari, revealed promising results in terms of hand functionality recovering, highlighting greater improvements for the patients enrolled in the experimental arm, that use the proposed telerehabilitation system, with respect to those of the control arm, which perform similar rehabilitation exercises using common objects.
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Fox, Alice J. Sophia Women's & Children's Health Faculty of Medicine UNSW. "Non-invasive procedure for fetal electrocardiography." Awarded by:University of New South Wales. Women's & Children's Health, 2007. http://handle.unsw.edu.au/1959.4/41240.
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Antenatal fetal surveillance is a field of increasing importance in modern obstetrics. Measurements extracted (such as fetal heart rate) from antenatal fetal monitoring techniques have the potential to reduce the social, personal and financial burdens of fetal death on families, health care systems and the community. Techniques to monitor the fetus through pregnancy have been developed with the aim of providing information to enable the clinician to diagnose fetal wellbeing, characterise development and detect abnormality. An early diagnosis before delivery may increase the effectiveness of the appropriate treatment. Over the years, various research efforts have been carried out in the field of fetal electrocardiography by attaching surface electrodes to the maternal body. Unfortunately the desired fetal heartbeat signals at the electrode output are buried in an additive mixture of undesired interference disturbances. In this thesis, a non-invasive fetal electrocardiogram machine has been designed, constructed and implemented. This machine is composed of three modified electrocardiogram circuits and an external soundcard. Data was acquired from four surface electrodes placed on the maternal body. Eleven pregnant subjects, with a gestation age between the 30th and 40th weeks of pregnancy, were used to investigate the validity of this machine. Fetal R-waves were detected in 72.7 percent of subjects. The development of a non-invasive machine, capable of detecting and recording valuable anatomic and electrophysiological information of a fetus, represents an important tool in clinical and investigative obstetrics.
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Bevilacqua, Elisa. "Non-invasive prenatal testing: a new era in fetal medicine." Doctoral thesis, Universite Libre de Bruxelles, 2020. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/304668.
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Les anomalies chromosomiques sont une cause majeure de morbidité et de mortalité périnatales. Le dépistage de ces affections a toujours été crucial pour une prise en charge optimale des femmes enceintes.Initialement, le dépistage de trisomie 21 était uniquement basé selon le risque lié à l’âge maternel. L’ajout de différents marqueurs biochimiques sériques constituant successivement les double, triple et quadruple tests a pu améliorer le taux de détection. Néanmoins, c’est en 1997 qu’apparaît un point tournant de l’histoire de dépistage des trisomies :l’introduction de la mesure de la clarté nucale à l’échographie du premier trimestre.Depuis 2011, de nouvelles recherches se sont concentrées sur le dépistage prénatal non invasif (DPNI) utilisant l'ADN fœtal libre circulant dans le sang maternel. Cette technique a suggéré directement une supériorité marquée pour la détection de la trisomie 21 comparée à toutes les autres méthodes de dépistage connues. Rapidement, ce test a été introduit en pratique clinique dans le monde entier sans une évaluation préalable et approfondie, que ce soit au niveau scientifique, technique ou éthique.Les objectifs de cette thèse étaient de fournir des réponses aux diverses questions persistantes concernant l’utilisation clinique des tests de dépistages basés sur ADN fœtal libre dans la circulation maternelle.À notre connaissance, nous sommes la première équipe à essayer d'évaluer le taux d'échec et la performance du DPNI effectué par différents laboratoires utilisant différentes méthodes analytiques. Nous avons démontré que les approches « DANSR » (approche ciblée sur les chromosomes d’intérêt) et « GW-MPS » (approche globale sur les séquences géniques reparties sur la totalité du génome par un séquençage à haut débit) offraient toutes les deux un taux échec bas avec une bonne performance dans la détection des trisomies 21, 13 et 18. Cependant, le niveau de fraction fœtale semble varier d'un laboratoire à l'autre et n’est, par conséquent, pas comparable. Nous avons également observé que le taux d'échec des laboratoires avec un test « home-brew » était 4 fois supérieur à celui des tests commerciaux développés par les laboratoires en interne. De plus, aucune pertinence clinique de la divulgation des aneuploïdies autres que les 3 trisomies communes décelées par les DPNI « GW-MPS » n’a pu être démontrée.Ensuite, nous nous sommes intéressés au groupe particulier des grossesses gémellaires. Dans ce groupe, le DPNI était faisable mais il était associé à un taux d'échec supérieur aux grossesses uniques, tout en fournissant un taux de détection moindre des trisomies communes. Un poids maternel élevé et la conception par fécondation in vitro étaient des facteurs indépendants associés à l’échec du test. De plus, il faut souligner l’importance de développer des normes de contrôle de qualité pour les analyses faites sur l’ADN fœtal libre. Nous avons aussi étudié les modifications de l’ADN fœtal libre après une mort fœtale en raison d’une aneuploïdie chez l’un des deux fœtus lors d’une grossesse gémellaire. Après le décès du fœtus atteint, la fraction fœtale de l’ADN libre circulant dans le sang maternel a montré une évolution imprévisible, pouvant augmenter, diminuer ou rester stable dans le temps. Par conséquent, ces résultats déconseillent l’utilisation du DPNI en cas de décès d’un des deux fœtus, même après un intervalle de temps de plusieurs semaines.Notre attention s’est ensuite portée vers la performance du DPNI pour le dépistage des anomalies autres que les 3 trisomies communes. Nous avons d’abord étudié la performance du DPNI pour les anomalies des chromosomes sexuels ainsi que les caractéristiques des patientes optant pour ce test. Plus de la moitié des patientes ayant eu un DPNI ont également souhaité le dépistage des anomalies des chromosomes sexuels. Les valeurs prédictives positives suivantes ont été observées :24% pour 45 X et 47 XXX et environ 71% pour 47 XXY et 47 XYY. Ainsi, la recherche d’anomalies des chromosomes sexuels peut causer la détection accidentelle d’anomalies chromosomiques sans conséquence clinique. Par conséquent, un conseil génétique est obligatoire dans toutes ces situations, de même qu’un examen invasif pour un caryotype fœtal de confirmation.Ensuite, nous avons montré que le test à ADN fœtal libre utilisant une technologie ciblée basée sur le microarray permettait d'identifier les grossesses à risque accru de délétions 22q11.2. Cependant, des données fiables sur les performances du DPNI pour le syndrome 22q11.2 sont encore manquantes, et des recherches plus poussées sont nécessaires. Depuis 2015, nous participons à une étude prospective, multicentrique et en aveugle, qui évalue cliniquement un test d’ADN fœtal libre pour la détection de délétions ou de duplications dans la région 22q11. Le recrutement s’est terminé le 1er novembre 2019.Enfin, en décrivant le profil et le choix des patientes belges soumises à un test à ADN fœtal libre, nous avons observé un changement vers une population à faible risque, ce qui peut entrainer une réduction de la valeur prédictive positive du test. Il est donc primordial que cet effet soit connu des professionnels de la santé qui conseillent, prescrivent et interprètent ces tests.En conclusion, notre recherche a démontré la complexité des tests à ADN fœtal libre circulant dans le sang maternel, non seulement du point de vue technique, mais également en termes de conseils aux patients avant et après le test, ce qui requière des connaissances et compétences spécifiques des médecins proposant ces tests.L’ère du test à ADN fœtal libre circulant dans le sang maternel n’en est qu’à ses débuts. Notre travail n’a exploré qu’une petite partie de l’énorme potentiel de ce nouvel outil de dépistage des aneuploïdies.L’intégration responsable des innovations dans la pratique clinique reste, aujourd’hui, l’un des défis majeurs.<br>Doctorat en Sciences médicales (Médecine)<br>info:eu-repo/semantics/nonPublished
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SULAS, ELEONORA. "Development of a Novel Dataset and Tools for Non-Invasive Fetal Electrocardiography Research." Doctoral thesis, Università degli Studi di Cagliari, 2020. http://hdl.handle.net/11584/284403.
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This PhD thesis presents the development of a novel open multi-modal dataset
for advanced studies on fetal cardiological assessment, along with a set of signal
processing tools for its exploitation. The Non-Invasive Fetal Electrocardiography
(ECG) Analysis (NInFEA) dataset features multi-channel electrophysiological
recordings characterized by high sampling frequency and digital resolution,
maternal respiration signal, synchronized fetal trans-abdominal pulsed-wave
Doppler (PWD) recordings and clinical annotations provided by expert
clinicians at the time of the signal collection. To the best of our knowledge,
there are no similar dataset available.
The signal processing tools targeted both the PWD and the non-invasive
fetal ECG, exploiting the recorded dataset. About the former, the study focuses
on the processing aimed at the preparation of the signal for the automatic
measurement of relevant morphological features, already adopted in the
clinical practice for cardiac assessment. To this aim, a relevant step is the automatic
identification of the complete and measurable cardiac cycles in the PWD
videos: a rigorous methodology was deployed for the analysis of the different
processing steps involved in the automatic delineation of the PWD envelope,
then implementing different approaches for the supervised classification of the
cardiac cycles, discriminating between complete and measurable vs. malformed
or incomplete ones. Finally, preliminary measurement algorithms were also developed
in order to extract clinically relevant parameters from the PWD.
About the fetal ECG, this thesis concentrated on the systematic analysis of
the adaptive filters performance for non-invasive fetal ECG extraction processing,
identified as the reference tool throughout the thesis. Then, two studies
are reported: one on the wavelet-based denoising of the extracted fetal ECG
and another one on the fetal ECG quality assessment from the analysis of the
raw abdominal recordings.
Overall, the thesis represents an important milestone in the field, by promoting
the open-data approach and introducing automated analysis tools that
could be easily integrated in future medical devices.
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Giffard-Roisin, Sophie. "Personnalisation non-invasive de modèles électrophysiologiques cardiaques à partir d'électrogrammes surfaciques." Thesis, Université Côte d'Azur (ComUE), 2017. http://www.theses.fr/2017AZUR4092/document.
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L'objectif de cette thèse est d'utiliser des données non-invasives (électrocardiogrammes, ECG) pour personnaliser les principaux paramètres d'un modèle électrophysiologique (EP) cardiaque pour prédire la réponse à la thérapie de resynchronisation cardiaque. La TRC est un traitement utilisé en routine clinique pour certaines insuffisances cardiaques mais reste inefficace chez 30% des patients traités impliquant une morbidité et un coût importants. Une compréhension précise de la fonction cardiaque propre au patient peut aider à prédire la réponse à la thérapie. Les méthodes actuelles se basent sur un examen invasif au moyen d’un cathéter qui peut être dangereux pour le patient. Nous avons développé une personnalisation non-invasive du modèle EP fondée sur une base de données simulée et un apprentissage automatique. Nous avons estimé l'emplacement de l'activation initiale et un paramètre de conduction global. Nous avons étendu cette approche à plusieurs activations initiales et aux ischémies au moyen d'une régression bayésienne parcimonieuse. De plus, nous avons développé une anatomie de référence afin d'effectuer une régression hors ligne unique et nous avons prédit la réponse à différentes stimulations à partir du modèle personnalisé. Dans une seconde partie, nous avons étudié l'adaptation aux données ECG à 12 dérivations et l'intégration dans un modèle électromécanique à usage clinique. L'évaluation de notre travail a été réalisée sur un ensemble de données important (25 patients, 150 cycles cardiaques). En plus d'avoir des résultats comparables avec les dernières méthodes d'imagerie ECG, les signaux ECG prédits présentent une bonne corrélation avec les signaux réels<br>The objective of this thesis is to use non-invasive data (body surface potential mapping, BSPM) to personalise the main parameters of a cardiac electrophysiological (EP) model for predicting the response to cardiac resynchronization therapy (CRT). CRT is a clinically proven treatment option for some heart failures. However, these therapies are ineffective in 30% of the treated patients and involve significant morbidity and substantial cost. The precise understanding of the patient-specific cardiac function can help to predict the response to therapy. Until now, such methods required to measure intra-cardiac electrical potentials through an invasive endovascular procedure which can be at risk for the patient. We developed a non-invasive EP model personalisation based on a patient-specific simulated database and machine learning regressions. First, we estimated the onset activation location and a global conduction parameter. We extended this approach to multiple onsets and to ischemic patients by means of a sparse Bayesian regression. Moreover, we developed a reference ventricle-torso anatomy in order to perform an common offline regression and we predicted the response to different pacing conditions from the personalised model. In a second part, we studied the adaptation of the proposed method to the input of 12-lead electrocardiograms (ECG) and the integration in an electro-mechanical model for a clinical use. The evaluation of our work was performed on an important dataset (more than 25 patients and 150 cardiac cycles). Besides having comparable results with state-of-the-art ECG imaging methods, the predicted BSPMs show good correlation coefficients with the real BSPMs
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Puszyk, William Matthew. "Epigenetics of cell-free plasma DNA for non-invasive prenatal diagnosis of fetal aneuploidies." Thesis, University of Warwick, 2008. http://wrap.warwick.ac.uk/1059/.
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Since the discovery of cell-free fetal DNA in the circulation of pregnant women fetal-specific DNA biomarkers for non-invasive prenatal diagnosis of fetal aneuploidy have been sought. A model system assessing the DNA methylation of placental DNA and adult peripheral leukocyte DNA has been developed previously to represent fetal and maternal plasma DNA. To use DNA methylation to detect specific DNA molecules it is desirable that cellfree plasma DNA maintains the methylation profile of its tissue source. Using the imprinted gene GNAS1, a test has been developed to assess, for the first time the relative abundance of methylated and unmethylated DNA circulating in plasma. Methylated and unmethylated DNA sequences were found in equal abundance. If this finding is applicable to all plasma DNA sequences, we conclude that the steadystate concentration of DNA in methylated and unmethylated form is a reliable indicator of its input into the circulation. We have also investigated whether the abundances of different single copy gene sequences in cell-free plasma DNA are equal. Using real-time PCR, the relative abundances of six unique genomic DNA sequences in plasma were assessed. We find that plasma DNA from different sequences is not present in equal abundance in normal healthy individuals. The relative abundance of sequences tested differed by as much as 12.3 fold. We present a panel of novel candidate epigenetic biomarkers which have been identified using the model system. Of 366 DNA regions tested 3% were found to be differential. Further characterisation of these candidate epigenetic biomarkers has revealed limitations of the model system. In view of these results, future epigenetic biomarker development should be achieved by a direct assessment of first trimester plasma DNA.
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Tasinato, Paola. "Non-medical applications of non invasive prenatal testing: ethical issues and apllicabilities." Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3423073.
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The possibility of obtaining material for foetal molecular analysis without the need of invasive procedures has been a long wished improvement of practice in prenatal diagnostics. The demonstration of the presence of foetal cells and circulating foetal free-DNA in a sample of mother-to-be’s blood promised that a non-invasive approach for prenatal diagnostics is near to becoming a reality.
The presence of foetal cells (albeit in low numbers) in maternal blood has been known since 1893, when Schomorl [1] described throphoblast cells in lung circulation of pregnant women who deceased from eclampsia. However, following the first observation numerous attempts to isolate these cells have proven disappointing. The main reasons for the lack of success with fetal cells isolation can be attributed to the very tiny proportion of fetal cells in the total maternal blood cell population. Moreover, isolation of fetal cells failed to demonstrate the origin of these cells using genetic profiling.
The presence of cell-free foetal circulating DNA sequences in the plasma of pregnant women was first described in 1997, when the Lo group [2] reported the presence of Y chromosome DNA sequences in pregnant circulation.
The demonstration of foetal genetic material in maternal circulation incited a new era of non-invasive prenatal diagnostics based on free foetal DNA, with the purpose of replacing the invasive approaches based on villi sampling, cordonocentesis and amniocentesis. Obtaining chorionic villi, amniocentesis or cord blood specimens is expensive and requires an invasive procedure that carries a small risk to the foetus and the possibility of adverse maternal effects, such as unnerving risk of miscarriage. Moreover, these tests are not provided until late in the first trimester thus implying a rate – limiting step in the provision of prenatal diagnosis: only pregnant women at the highest risk of having a foetus with a genetic syndrome or another disorder of major clinical significance have been eligible to these tests.
In this study we considered that genetic prenatal diagnosis could have forensic applications, in particular in cases of rape resulting in pregnancy. So, we explored the opportunity and ethical issues related to the introduction of non-invasive prenatal testing for non-medical applications, such as sex determination and paternity testing. In particular, based on our laboratory analyses we achieved proof of principle of a non-invasive test for forensic purposes.
We obtain approval for our studies from the Ethics Committee of the University - Hospital of Padova (Protocol n. 2105 P / 2010), Italy. First of all we demonstrated the applicability of cell free DNA in human identification. Then, we enrolled pregnant women and their partner and investigated the STR profiles obtained from free DNA and nucleated red blood cells in peripheral blood of pregnant women that were compared to profiles of the putative father, in order to define paternity. The STR profiles in free DNA were investigated using consolidated methods, by performing multiplex PCR and sequencing, without succesfull results that we attributed to the low sensitivity of the method. This result pushed us to investigate the applicability of new high throughput technologies (e.g. next generation sequencing) in plasma DNA of mother’s-to be. This new approach, of potential interest for forensic genetics, seems to be promizing thank to its high sensitivity.
The best results with profiling fetal DNA from maternal blood specimens were obtained from DNA profiling of nucleated red blood cells of embryonic origin when enrichment by Fluorescent Activated Cell Sorting (FACS) was performed. For enrichment a combination of monoclonal antibodies was employed: all amplified alleles amplified from sorted cells, others than those of the mother, matched the alleles of the putative father.
Our study, which is the first one to investigate DNA profiling analysis on nucleated fetal red blood cells for forensic genetics, demonstrated that non-invasive prenatal paternity testing could be developed as a tool for the identification of perpetrators of rape in case of resulting pregnancy. More efforts need to be spend to optimize the isolation of fetal cells. The proof of principle that non invasive prenatal paternity testing on DNA of rare fetal cells circulating in pregnant blood is feasible justifies further efforts in developing this new approach.<br>La possibilità di ottenere materiale genetico di origine fetale per diagnosi prenatale senza l’ausilio di procedure invasive è sempre stato considerato un interesse condiviso in campo ostetrico ginecologico. Da quando è stata dimostrata la presenza di cellule fetali e di DNA plasmatico entrambi di origine fetale nel circolo periferico delle donne in gravidanza questa opportunità ha iniziato ad essere indagata al fine di poter essere proposta nella pratica clinica.
Che cellule fetali siano presenti, anche se in numero molto esiguo, nel circolo periferico delle donne gravide è noto fin dal 1893, quando il patologo tedesco Schomorl ha descritto la presenza di trofoblasti nel circolo polmonare di 14 donne decedute per eclampsia [1], ma i tentativi di isolamento sono sempre risultati fallimentari. I principali motivi del mancato successo sono da ricercare nella esiguità di questa quota cellulare e nella mancanza di dimostrazione dell’origine fetale attraverso tecniche di profiling genetico della stessa.
Nel 1997 il gruppo di Yo [2] ha dismostrato la presenza di frammenti di DNA libero di origine fetale nel sangue periferico delle donne gravide, attraverso l’amplificazione di sequenze del cromosoma Y nel plasma di queste donne.
Così, dalla dimostrazione della presenza di materiale genetico di origine fetale nel circolo materno è iniziata una nuova era della diagnosi prenatale non invasiva, particolarmente incentrata sulla frazione di acidi nucleici liberi. Infatti, il recupero dei villi e/o del liquido amniotico sono gravati da costi sostenuti e dai rischi legati all’invasività del prelievo sia per il prodotto del concepimento che per la donna, con un seppur basso ma esistente rischio di perdita della gravidanza stessa.
Inoltre, questi approcci invasivi sono eseguiti non prima del termine del primo trimestre di gravidanza o nel secondo: essi sono proposti solo alle donne con già rilevato rischio di sindromi genetiche malformative o con rischio aumentato in funzione dell’età materna.
Nel nostro studio abbiamo considerato che la diagnosi prenatale può avere anche applicazioni forensi, in particolare nei casi di gravidanza esitata dopo stupro. Abbiamo così analizzato l’opportunità e la valenza etica di introdurre tecniche di diagnosi prenatale non invasiva per scopi non squisitamente clinici, come la determinazione del sesso e della paternità.
Abbiamo ottenuto l’approvazione del Comitato Etico dell’Azienda Ospedaliero Universitaria di Padova (Protocollo n. 2105 P / 2010), attraverso la preliminare proposta di considerazioni bioetiche sullo studio.
Abbiamo, dunque, iniziato il nostro studio attraverso la dimostrazione dell’applicabilità della frazione libera del DNA, cosiddetto DNA plasmatico o DNA libero circolante, ai fini dell’identificazione personale in soggetti sani, comprese donne non gravide. Quindi, abbiamo arruolato donne in gravidanza afferenti al Servizio di Gestione della Gravidanza della Divisione Ostetrica dell’Azienda Ospedaliera di Padova e i loro partner in funzione di investigare i profili genetici degli short tandem repeats (STR) usati in genetica forense ai fini di identificazione personale, ottenuti dalla frazione di DNA libero e dagli eritroblasti fetali entrambi circolanti nel sangue periferico delle donne e di confrontarli con il profilo dei partner al fine di definirne e dimostrarne la paternità.
Nella frazione libera di DNA i consolidati metodi di amplificazione del DNA non hanno permesso di dimostrare la presenza di profilo aggiuntivo rispetto a quello materno. Questo ci ha spinto ad indagare l’applicabilità delle più recenti tecnologie come il sequenziamento di ultima generazione, cosiddetto pyrosequenzing, nel plasma delle future mamme. Questo approccio, di nuovo interesse nella disciplina della genetica forense, ci ha permesso di rilevare la presenza di sequenze fetali nel plasma materno.
Migliori risultati li abbiamo ottenuti isolando gli eritroblasti di origine fatale attraverso arricchimento con tecniche di sorting cellulare (Fluorescent Activated Cell Sorting, FACS), con una combinazione di anticorpi monoclonali: tutti gli alleli amplificati diversi da quelli materni sono risultati essere coerenti con quelli del partner, ovvero del “presunto” padre, poi confermati alla nascita con quelli del bambino.
Il nostro studio, che rappresenta la prima apllicazione dell’impiego degli eritroblasti fetali in genetica forense, dimostra che la diagnosi di paternità non invasiva può rapprentare un valido mezzo nell’identificazione della figura dello stupratore in caso di successiva gravidanza. Altri studi dovranno comunque essere eseguiti al fine di ottimizzare l’isolamento delle cellule fetali.
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Gibbs, Oliver. "Quantification of Pulsatile Changes in Retinal Vessel Calibre to Improve Non-Invasive Cardiovascular Risk Evaluation." Thesis, The University of Sydney, 2016. http://hdl.handle.net/2123/18586.
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Background: Large epidemiological studies show that changes in retinal vessel caliber are independently associated with coronary artery disease and stroke. Hence, retinal photography and vessel measurement have excellent potential for the non-invasive risk prediction of these important pathological conditions. This study aims to improve the precision of cardiovascular risk evaluation using retinal photography by developing an ECG gated method for the study of the pulsatility in retinal vessels. Methods: High-resolution red-free digital photographs were taken throughout the cardiac cycle in ten healthy volunteers using an ECG gating method developed by our biomedical engineering department. Vessel diameters were measured using a semi-automated computer analysis program. The ECG gating methodology was then validated in ten patients with known or suspected coronary disease and compared to un-gated photography. Results: We were able to detect a statistically significant difference (p < 0.001) between trough and peak measurements with mean changes from trough to peak being 3%. Retinal arteriolar pulsatility corresponded well with pulse waves from the temporal and carotid arteries, with a trough occurring in systole, a peak in early diastole and a slow decline in late diastole. Minimum variability between gated photographs occurred in systole with maximum variability occurring in early diastole. ECG gating resulted in a significant (p<0.001) reduction in variability with variances of 1.98µm with and 4.00µm without ECG-gating. Conclusion: ECG gated retinal photography enables the detection of small changes in retinal vessel diameter throughout the cardiac cycle. The retinal arterioles demonstrate similar pulsatility to other peripheral arteries with a change in diameter of 3%. ECG gating significantly reduces variability in retinal arteriolar diameter measurements.
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Al-Mufti, Raghad Abdul Wahab Mohamed Latif. "Non-invasive prenatal diagnosis of chromosomal abnormalities by isolation of fetal cells from the maternal circulation." Thesis, King's College London (University of London), 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.404600.
Full textBooks on the topic "Non invasive fetal ECG"
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Rudelstorfer, Rudolf. Fetal heat flux: Non-invasive diagnosis of fetal distress. Smith-Gordon, 1990.
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(Foreword), H. Janische, ed. Fetal Heart Flux (Non-Invasive Diagnosis in Medicine & Paediatrics). Smith-Gordon & Co Ltd, 1990.
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Jacquemyn, Yves, and Anneke Kwee. Antenatal and intrapartum fetal evaluation. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198713333.003.0006.
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Antenatal and intrapartum fetal monitoring aim to identify the beginning of the process of fetal hypoxia before irreversible fetal damage has taken place. Fetal movement counting by the mother has not been reported to be of any benefit. The biophysical profile score, incorporating ultrasound and fetal heart rate monitoring, has not been proven to reduce perinatal mortality in randomized trials. Doppler ultrasound allows the exploration of the perfusion of different fetal organ systems and provides data on possible hypoxia and fetal anaemia. Maternal uterine artery Doppler can be used to select women with a high risk for intrauterine growth restriction and pre-eclampsia but does not directly provide information on fetal status. Umbilical artery Doppler has been shown to reduce perinatal mortality significantly in high-risk pregnancies (but not in low-risk women). Adding middle cerebral artery Doppler to umbilical artery Doppler does not increase accuracy for detecting adverse perinatal outcome. Ductus venosus Doppler demonstrates moderate value in diagnosing fetal compromise; it is not known whether its use adds any value to umbilical artery Doppler alone. Cardiotocography (CTG) reflects the interaction between the fetal brain and peripheral cardiovascular system. Prelabour routine use of CTG in low-risk pregnancies has not been proven to improve outcome; computerized CTG significantly reduces perinatal mortality in high-risk pregnancies. Monitoring the fetus during labour with intermittent auscultation has not been compared to no monitoring at all; when compared with CTG no difference in perinatal mortality or cerebral palsy has been noted. CTG does lower neonatal seizures and is accompanied by a statistically non-significant rise in caesarean delivery. Fetal blood sampling to detect fetal pH and base deficit lowers caesarean delivery rate and neonatal convulsions when used in adjunct to CTG. Determination of fetal scalp lactate has not been shown to have an effect on neonatal outcome or on the rate of instrumental deliveries but is less often hampered by technical failure than fetal scalp pH. Analysis of the ST segment of the fetal ECG (STAN®) in combination with CTG during labour results in fewer vaginal operative deliveries, less need for neonatal intensive care, and less use of fetal blood sampling during labour, without a change in fetal metabolic acidosis when compared to CTG alone.
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Archer, Nick, and Nicky Manning. Other investigations. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198766520.003.0008.
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This chapter considers other fetal cardiovascular investigations, including discussion on invasive testing, examination of sample, non-invasive testing, parental blood sampling, fetal electrocardiography, and magnetic resonance imaging.
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Sabharwal, Nikant, Chee Yee Loong, and Andrew Kelion. Introduction to nuclear cardiology. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780199206445.003.0001.
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Introduction 2Important milestones 4Relation to other imaging modalities 6The cardiologist of the early twenty-first century takes for granted the wide range of imaging modalities at his/her disposal, but it was not always so. At the beginning of the 1970s, invasive cardiac catheterization was the only reliable cardiac imaging technique. Subsequently, nuclear cardiology investigations led the way in the non-invasive assessment of cardiac disease. Some of the principles underlying these investigations [e.g. electrocardiogram (ECG)-triggered gating] have also been of great importance in the development of other imaging modalities....
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Yilmaz, Ali, and Anca Florian. Myocarditis: imaging techniques. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780198784906.003.0367.
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The clinical presentation of myocarditis is multifaceted and electrocardiogram (ECG) changes as well as biomarkers tend to be non-specific. Therefore, the diagnosis of myocarditis can be challenging and should be based on an integrated approach including patient history, physical examination, non-invasive tests such as ECG and serum biomarkers, and non-invasive cardiac imaging. As myocarditis may lead to global ventricular dysfunction, regional wall motion abnormalities, and/or diastolic dysfunction, echocardiography should be routinely performed. However, hallmarks of acute myocarditis comprise structural changes such as cardiomyocyte swelling, an increase in extracellular space and water content, accumulation of inflammatory cells, potential necrosis or apoptosis of cardiomyocytes, and myocardial remodelling with fibrotic tissue replacement that can be depicted by cardiovascular magnetic resonance. Nuclear techniques are still not routinely recommended for the work-up of myocarditis—with the possible exception of suspected sarcoidosis—due to limited data, limited diagnostic specificity, limited availability, and risk from radiation exposure. This chapter focuses on those non-invasive cardiac imaging techniques that are used in daily clinical practice for work-up of suspected myocarditis. However, as research continues and novel imaging techniques become available, it is hoped that even more accurate and timely diagnosis of myocarditis will be possible in the near future.
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Adam, Sheila, Sue Osborne, and John Welch. Cardiovascular problems. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199696260.003.0005.
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The cardiovascular chapter discusses the physiology, assessment, and treatment of cardiovascular disorders in the critically ill patient. It gives an in-depth explanation of non-invasive and invasive monitoring procedures (such as ECG, pulse oximetry, oesophageal Doppler, and pulmonary artery catheterization). It includes the measurement of oxygen delivery and consumption, and explains diagnostic techniques such as echocardiography. The chapter includes the management and optimization of goal-directed therapies for specific conditions including coronary heart disease (such as myocardial infarction and angina), shock, valvular heart disease, and heart failure. Interventional treatment and specific drug therapy are discussed, including percutaneous coronary intervention, cardiac pacing, and electrical conversion.
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Sabharwal, Nikant, Parthiban Arumugam, and Andrew Kelion. Radionuclide ventriculography. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198759942.003.0005.
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Radionuclide ventriculography (RNV) was the first reliable non-invasive method of assessing left ventricular (LV) function, and established nuclear cardiology as a clinical discipline. The subsequent development of other imaging modalities, particularly echocardiography, has led to a sharp decline in the number of studies performed, but RNV still has a role in situations where reproducible serial assessments of LV ejection fraction are required. Equilibrium RNV (ERNV) is the most straightforward and commonly performed style of RNV, and this chapter therefore focuses on ERNV, covering blood-pool labelling, principles of electrocardiogram (ECG) gating, acquisition, processing and interpretation, and clinical value in relation to ERNV. A section on first-pass radionuclide ventriculography is also included.
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Banerjee, Amitava, and Kaleab Asrress. Screening for cardiovascular disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0351.
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Screening involves testing asymptomatic individuals who have risk factors, or individuals who are in the early stages of a disease, in order to decide whether further investigation, clinical intervention, or treatment is warranted. Therefore, screening is classically a primary prevention strategy which aims to capture disease early in its course, but it can also involve secondary prevention in individuals with established disease. In the words of Geoffrey Rose, screening is a ‘population’ strategy. Examples of screening programmes are blood pressure monitoring in primary care to screen for hypertension, and ultrasound examination to screen for abdominal aortic aneurysm. The effectiveness and feasibility of screening are influenced by several factors. First, the diagnostic accuracy of the screening test in question is crucial. For example, exercise ECG testing, although widely used, is not recommended in investigation of chest pain in current National Institute for Health and Care Excellence guidelines, due to its low sensitivity and specificity in the detection of coronary artery disease. Moreover, exercise ECG testing has even lower diagnostic accuracy in asymptomatic patients with coronary artery disease. Second, physical and financial resources influence the decision to screen. For example, the cost and the effectiveness of CT coronary angiography and other new imaging modalities to assess coronary vasculature must be weighed against the cost of existing investigations (e.g. coronary angiography) and the need for new equipment and staff training and recruitment. Finally, the safety of the investigation is an important factor, and patient preferences and physician preferences should be taken into consideration. However, while non-invasive screening examinations are preferable from the point of view of patients and clinicians, sometimes invasive screening tests may be required at a later stage in order to give a definitive diagnosis (e.g. pressure wire studies to measure fractional flow reserve in a coronary artery). The WHO’s principles of screening, first formulated in 1968, are still very relevant today. Decision analysis has led to ‘pathways’ which guide investigation and treatment within screening programmes. There is increasing recognition that there are shared risk factors and shared preventive and treatment strategies for vascular disease, regardless of arterial territory. The concept of ‘vascular medicine’ has gained credence, leading to opportunistic screening in other vascular territories if an individual presents with disease in one territory. For example, post-myocardial infarction patients have higher incidence of cerebrovascular and peripheral arterial disease, so carotid duplex scanning and measurement of the ankle–brachial pressure index may be valid screening approaches for arterial disease in other territories.
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Especificaciones técnicas de la OMS para dispositivos automáticos de medición de la presión arterial no invasivos y con brazalete. Organización Panamericana de la Salud, 2020. http://dx.doi.org/10.37774/9789275323052.
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La hipertension es el principal factor de riesgo modificable de algunas enfermedades graves como las enfermedades cardiovasculares (accidentes cerebrovasculares y cardiopatías isquémicas), la preeclampsia y la eclampsia (una causa muy importante de muerte en las embarazadas, así como de retraso del crecimiento fetal y mortinatos) y la enfermedad renal crónica. A nivel mundial, más de mil millones de personas tienen hipertensión, y la prevalencia es mayor en los países de ingresos bajos y medianos. La medición exacta de la presión arterial es esencial para detectar y tratar adecuadamente a las personas con hipertensión, un trastorno que constituye un asesino silencioso que causa pocos síntomas. La falta de acceso a dispositivos de determinación de la presión arterial exactos y asequibles constituye un obstáculo importante para una atención médica adecuada, en particular en los entornos de recursos escasos. La medición manual está siendo reemplazada gradualmente por la medición automatizada debido a los problemas ambientales derivados del mercurio, la falta de calibración y las mediciones incorrectas de los dispositivos aneroides en la práctica clínica, así como por la exactitud uniforme superior que ofrecen los dispositivos automáticos validados. Sin embargo, con frecuencia existe cierta preocupación respecto a la exactitud de los dispositivos automatizados que no se han validado. Este documento actualiza la orientación de la OMS sobre dispositivos de medición de la presión arterial del 2005. También responde a la preocupación existente por la carencia de dispositivos exactos y de buena calidad, especialmente en los países de ingresos bajos y medianos mediante una consulta técnica y examen de expertos. Versión oficial en español de la obra original en inglés: WHO technical specifications for automated non-invasive blood pressure measuring devices with cuff. © World Health Organization, 2020 ISBN 978-92-4-000266-1 (print version)
Book chapters on the topic "Non invasive fetal ECG"
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Kahankova, Radana, Radek Martinek, and Petr Bilik. "Non-invasive Fetal ECG Extraction from Maternal Abdominal ECG Using LMS and RLS Adaptive Algorithms." In Proceedings of the Third International Afro-European Conference for Industrial Advancement — AECIA 2016. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-60834-1_27.
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Uv, Julie Johanne, Lena Myklebust, Hamid Khoshfekr Rudsari, Hannes Welle, and Hermenegild Arevalo. "3D Simulations of Fetal and Maternal Ventricular Excitation for Investigating the Abdominal ECG." In Computational Physiology. Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-05164-7_2.
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AbstractCongenital heart disease (CHD) is a leading cause of infant death. To diagnose CHD, recordings from abdominal fetal electrocardiograms (fECG) can be used as a non-invasive tool. However, it is challenging to extract the fetal signal from fECG recordings partly due to the lack of data combining fECG recordings with a ground truth for the fetal signal, which can be obtained by using a scalp electrode during delivery. In this study, we present a computational model of a pregnant female torso, in which we simulate fetal and maternal ventricular excitation during sinus rhythm to derive fECGs, so as to enable isolated measurement of the fetal and maternal signal contributions. To extract the fetal contribution from a combined signal, we apply an adaptive filtering algorithm to wavelet transformed signals. Further development of the model may enable improvements in the recording and processing capabilities for fECGs, the reliable estimation of fetal heart rates, and possibly interpretation of fetal signal morphologies that could improve the overall diagnostic significance of abdominal fECGs.
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Cuckle, H. "Impact of Improved Screening Efficiency on the Future Role of Non-Invasive Testing." In Fetal Cells and Fetal DNA in Maternal Blood. KARGER, 2001. http://dx.doi.org/10.1159/000062530.
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Sharma, Kamakshi, and Sarfaraz Masood. "Deep Learning-Based Non-invasive Fetal Cardiac Arrhythmia Detection." In Lecture Notes in Electrical Engineering. Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-16-3067-5_38.
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Zhong, Wei, Xuemei Guo, and Guoli Wang. "Non-invasive Fetal Electrocardiography Denoising Using Deep Convolutional Encoder-Decoder Networks." In Lecture Notes in Electrical Engineering. Springer Singapore, 2019. http://dx.doi.org/10.1007/978-981-32-9682-4_1.
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Vossaert, Liesbeth, Roni Zemet, and Ignatia B. Van den Veyver. "Advances in Non-Invasive Diagnosis of Single-Gene Disorders and Fetal Exome Sequencing." In Handbook of Genetic Diagnostic Technologies in Reproductive Medicine, 2nd ed. CRC Press, 2022. http://dx.doi.org/10.1201/9781003024941-27.
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Ley, S., D. Laqua, and P. Husar. "Simulation of Photon Propagation in Multi-layered Tissue for Non-invasive Fetal Pulse Oximetry." In IFMBE Proceedings. Springer International Publishing, 2014. http://dx.doi.org/10.1007/978-3-319-02913-9_91.
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Vrins, Frédéric, Christian Jutten, and Michel Verleysen. "Sensor Array and Electrode Selection for Non-invasive Fetal Electrocardiogram Extraction by Independent Component Analysis." In Independent Component Analysis and Blind Signal Separation. Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-30110-3_128.
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dos Santos, Jorge Roberto Lopes, Heron Werner, Gerson Ribeiro, and Simone Letícia Belmonte. "Combination of Non Invasive Medical Imaging Technologies and Virtual Reality Systems to Generate Immersive Fetal 3D Visualizations." In Digital Human Modeling: Applications in Health, Safety, Ergonomics and Risk Management. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-40247-5_10.
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Gałecka, Jerzy, Fryderyk Prochaczek, Adam Gacek, and Hanna Winiarska-Prochaczek. "Minimizing interference from cardiac stimulator pulse in the ECG recordings during the diagnostics of myocardial ischemia by non-invasive transcutaneous cardiac stimulation." In Innovations in Biomedical Engineering. Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-70063-2_17.
Full textConference papers on the topic "Non invasive fetal ECG"
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Vullings, Rik, Chris Peters, Massimo Mischi, Guid Oei, and Jan Bergmans. "Maternal ECG removal from non-invasive fetal ECG recordings." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.259675.
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Vullings, Rik, Chris Peters, Massimo Mischi, Guid Oei, and Jan Bergmans. "Maternal ECG removal from non-invasive fetal ECG recordings." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4397672.
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Subhashini, S., D. J. Jagannath, and A. Immanuel Selvakumar. "Extricating non invasive fetal ECG by adaptive optimization technique." In 2014 International Conference on Electronics and Communication Systems (ICECS). IEEE, 2014. http://dx.doi.org/10.1109/ecs.2014.6892659.
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Nikam, Sonal, and Shankar Deosarkar. "Fast ICA based technique for non-invasive fetal ECG extraction." In 2016 Conference on Advances in Signal Processing (CASP). IEEE, 2016. http://dx.doi.org/10.1109/casp.2016.7746138.
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Gundorff Sæderup, Rasmus, Henrik Zimmermann, Dagbjört Helga Eiríksdóttir, John Hansen, Johannes Struijk, and Samuel Emil Schmidt. "Comparison of Cardiotocography and Fetal Heart Rate Estimators Based on Non-Invasive Fetal ECG." In 2019 Computing in Cardiology Conference. Computing in Cardiology, 2019. http://dx.doi.org/10.22489/cinc.2019.249.
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Jaeger, Katharina M., Michael Nissen, Robert Richer, et al. "Machine Learning-based Detection of In-Utero Fetal Presentation from Non-Invasive Fetal ECG." In 2022 IEEE-EMBS International Conference on Biomedical and Health Informatics (BHI). IEEE, 2022. http://dx.doi.org/10.1109/bhi56158.2022.9926804.
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Peters, Chris, Rik Vullings, Jan Bergmans, Guid Oei, and Pieter Wijn. "Heart Rate Detection in Low Amplitude Non-Invasive Fetal ECG Recordings." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.259845.
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Peters, Chris, Rik Vullings, Jan Bergmans, Guid Oei, and Pieter Wijn. "Heart Rate Detection in Low Amplitude Non-Invasive Fetal ECG Recordings." In Conference Proceedings. Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE, 2006. http://dx.doi.org/10.1109/iembs.2006.4398848.
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AbuHantash, Ferial, Ahsan H. Khandoker, Georgios K. Apostolidis, and Leontios J. Hadjileontiadis. "Swarm Decomposition of Abdominal Signals for Non-invasive Fetal ECG Extraction." In 2021 43rd Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC). IEEE, 2021. http://dx.doi.org/10.1109/embc46164.2021.9631017.
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Baldazzi, "Giulia, Danilo Pani, and Hau-Tieng Wu." "Extraction Algorithm for Morphologically Preserved Non-Invasive Multi-Channel Fetal ECG." In 2022 Computing in Cardiology Conference. Computing in Cardiology, 2022. http://dx.doi.org/10.22489/cinc.2022.373.
Full textReports on the topic "Non invasive fetal ECG"
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Durgud, Meriem R., Vili K. Stoyanova, Nikolay T. Popov, et al. Non-invasive Prenatal Sex Identification Using Cell-free Fetal DNA in Maternal Circulation. "Prof. Marin Drinov" Publishing House of Bulgarian Academy of Sciences, 2018. http://dx.doi.org/10.7546/crabs.2018.12.14.
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Wideman, Jr., Robert F., Nicholas B. Anthony, Avigdor Cahaner, Alan Shlosberg, Michel Bellaiche, and William B. Roush. Integrated Approach to Evaluating Inherited Predictors of Resistance to Pulmonary Hypertension Syndrome (Ascites) in Fast Growing Broiler Chickens. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575287.bard.
Full textAbstract:
Background PHS (pulmonary hypertension syndrome, ascites syndrome) is a serious cause of loss in the broiler industry, and is a prime example of an undesirable side effect of successful genetic development that may be deleteriously manifested by factors in the environment of growing broilers. Basically, continuous and pinpointed selection for rapid growth in broilers has led to higher oxygen demand and consequently to more frequent manifestation of an inherent potential cardiopulmonary incapability to sufficiently oxygenate the arterial blood. The multifaceted causes and modifiers of PHS make research into finding solutions to the syndrome a complex and multi threaded challenge. This research used several directions to better understand the development of PHS and to probe possible means of achieving a goal of monitoring and increasing resistance to the syndrome. Research Objectives (1) To evaluate the growth dynamics of individuals within breeding stocks and their correlation with individual susceptibility or resistance to PHS; (2) To compile data on diagnostic indices found in this work to be predictive for PHS, during exposure to experimental protocols known to trigger PHS; (3) To conduct detailed physiological evaluations of cardiopulmonary function in broilers; (4) To compile data on growth dynamics and other diagnostic indices in existing lines selected for susceptibility or resistance to PHS; (5) To integrate growth dynamics and other diagnostic data within appropriate statistical procedures to provide geneticists with predictive indices that characterize resistance or susceptibility to PHS. Revisions In the first year, the US team acquired the costly Peckode weigh platform / individual bird I.D. system that was to provide the continuous (several times each day), automated weighing of birds, for a comprehensive monitoring of growth dynamics. However, data generated were found to be inaccurate and irreproducible, so making its use implausible. Henceforth, weighing was manual, this highly labor intensive work precluding some of the original objectives of using such a strategy of growth dynamics in selection procedures involving thousands of birds. Major conclusions, solutions, achievements 1. Healthy broilers were found to have greater oscillations in growth velocity and acceleration than PHS susceptible birds. This proved the scientific validity of our original hypothesis that such differences occur. 2. Growth rate in the first week is higher in PHS-susceptible than in PHS-resistant chicks. Artificial neural network accurately distinguished differences between the two groups based on growth patterns in this period. 3. In the US, the unilateral pulmonary occlusion technique was used in collaboration with a major broiler breeding company to create a commercial broiler line that is highly resistant to PHS induced by fast growth and low ambient temperatures. 4. In Israel, lines were obtained by genetic selection on PHS mortality after cold exposure in a dam-line population comprising of 85 sire families. The wide range of PHS incidence per family (0-50%), high heritability (about 0.6), and the results in cold challenged progeny, suggested a highly effective and relatively easy means for selection for PHS resistance 5. The best minimally-invasive diagnostic indices for prediction of PHS resistance were found to be oximetry, hematocrit values, heart rate and electrocardiographic (ECG) lead II waves. Some differences in results were found between the US and Israeli teams, probably reflecting genetic differences in the broiler strains used in the two countries. For instance the US team found the S wave amplitude to predict PHS susceptibility well, whereas the Israeli team found the P wave amplitude to be a better valid predictor. 6. Comprehensive physiological studies further increased knowledge on the development of PHS cardiopulmonary characteristics of pre-ascitic birds, pulmonary arterial wedge pressures, hypotension/kidney response, pulmonary hemodynamic responses to vasoactive mediators were all examined in depth. Implications, scientific and agricultural Substantial progress has been made in understanding the genetic and environmental factors involved in PHS, and their interaction. The two teams each successfully developed different selection programs, by surgical means and by divergent selection under cold challenge. Monitoring of the progress and success of the programs was done be using the in-depth estimations that this research engendered on the reliability and value of non-invasive predictive parameters. These findings helped corroborate the validity of practical means to improve PHT resistance by research-based programs of selection.