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Journal articles on the topic 'Non metastatic'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Trevizani, Maria Eduarda Salles, Fabio Albuquerque Marchi, Daniela Bizinelli, et al. "MicroRNA Profiles Distinguishing Metastatic from Non-Metastatic Salivary Mucoepidermoid Carcinoma." Journal of Clinical Medicine 14, no. 14 (2025): 4957. https://doi.org/10.3390/jcm14144957.

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Background/Objectives: Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Metastatic spread occurs in up to 80% of high-grade tumors; however, the mechanisms underlying this process are largely unknown. Large-scale microRNA (miRNA) expression profiling studies of human cancers have demonstrated that dysregulation of miRNA is frequently associated with many cancer types. This study aimed to investigate the miRNA profiles of metastatic and non-metastatic MECs. Methods: Using real-time RT-PCR (qPCR), we analyzed the expression of 377 miRNAs in four non-metas

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Trevizani, Maria Eduarda S., Katia K. Oliveira, Fabio A. Marchi, et al. "Abstract 3763: microRNAs associated with metastatic potential in salivary gland mucoepidermoid carcinoma." Cancer Research 83, no. 7_Supplement (2023): 3763. http://dx.doi.org/10.1158/1538-7445.am2023-3763.

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Abstract Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the salivary glands. Metastatic spread occurs in up to 80% of high-grade tumors and it is a strong predictor of poor outcome, however, the mechanisms underlying this process are largely unknown. Large-scale microRNA expression profiling studies of human cancers have demonstrated that dysregulation of miRNA is frequently associated with many cancer types. The aim of this study was to investigate the microRNA profile in metastatic versus non-metastatic MECs. Using Real Time RT-PCR (qPCR) we have analyzed the expression

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Wu, Jie, Hong-Lei Cui, Hongzhe Shi, et al. "Clinicopathological characteristics and prognosis of metastatic non-clear cell renal cell carcinoma." Journal of Clinical Oncology 43, no. 5_suppl (2025): 504. https://doi.org/10.1200/jco.2025.43.5_suppl.504.

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504 Background: Non-clear cell renal cell carcinoma (nccRCC) is a clinicopathological heterogeneous disease that comprises a complex mixture of different pathology subtypes, accounting for approximately 20% of all RCC cases. Due to its heterogeneity and rarity, standard treatment strategy for metastatic nccRCC remain poorly defined. Methods: We conducted retrospective analysis of 105 metastatic nccRCC patients at our center from June 2010 to April 2022. Demographic, clinicopathological, and systemic therapy data were collected. The data of 872 metastatic ccRCC patients were also collected for

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Wahyuni, Siska Dwiyantie, Sri Suryanti, Hasrayati Agustina, and Bethy Suryawathy Hernowo. "The Association of Clinicopathological Features with Metastatic Status in Infiltrative Urothelial Carcinoma of Bladder." Journal of Drug Delivery and Therapeutics 10, no. 6-s (2020): 99–102. http://dx.doi.org/10.22270/jddt.v10i6-s.4647.

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Background: Infiltrative urothelial carcinoma of bladder is an aggressive variant of bladder carcinoma. Most of the patients in their first encounter with doctors are diagnosed with advanced stages and many has metastasized. Metastasis is a process of malignant tumor cells migrating from its primary tumor location to other organs or sites inside the body via blood circulation or lymphatic system. Metastasis process is responsible for 90% cancer deaths compared to the primary tumor itself, infiltrative urothelial carcinoma of bladder. To reduce mortality, knowledge of the clinicopathological ch

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Nestler, Tim, Priya Dalvi, Friederike Haidl, et al. "Transcriptome analysis reveals upregulation of immune response pathways at the invasive tumour front of metastatic seminoma germ cell tumours." British Journal of Cancer 126, no. 6 (2022): 937–47. http://dx.doi.org/10.1038/s41416-021-01621-5.

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Abstract Background Testicular germ cell tumours (TGCTs) have a high metastasis rate. However, the mechanisms related to their invasion, progression and metastasis are unclear. Therefore, we investigated gene expression changes that might be linked to metastasis in seminomatous testicular germ cell tumour (STGCT) patients. Methods Defined areas [invasive tumour front (TF) and tumour centre (TC)] of non-metastatic (with surveillance and recurrence-free follow-up >2 years) and metastatic STGCTs were collected separately using laser capture microdissection. The expression of 760 genes related

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Alkhayat, Hana, and Chih-ho Hong. "Cutaneous Metastases from Non-Small Cell Lung Cancer." Journal of Cutaneous Medicine and Surgery 10, no. 6 (2006): 304–7. http://dx.doi.org/10.2310/7750.2006.00061.

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Background: Cutaneous metastases are an uncommon phenomenon that occurs in a few patients with metastatic disease. Early recognition of a cutaneous metastasis is important as it may be the presenting sign of an underlying malignancy. These metastases usually indicate advanced disease and carry a poor prognosis. Objectives: We present two cases with cutaneous metastasis from primary non-small cell lung cancer. We seek to familiarize dermatologists with the unusual presentations of cutaneous metastases. Conclusion: In our two cases, the diagnosis of the metastatic cutaneous lesion ultimately led

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kia, Vahid, Yousef Mortazavi, Mahdi Paryan, Alireza Biglari, and Samira Mohammadi-Yeganeh. "Exosomal miRNAs from highly metastatic cells can induce metastasis in non-metastatic cells." Life Sciences 220 (March 2019): 162–68. http://dx.doi.org/10.1016/j.lfs.2019.01.057.

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Suvilesh, Kanve Nagaraj, Yulia I. Nussbaum, Vijay Radhakrishnan, et al. "Abstract 267: Xenograft models of non-metastatic non-small cell lung cancer reveals micrometastasis-associated single cell composition." Cancer Research 82, no. 12_Supplement (2022): 267. http://dx.doi.org/10.1158/1538-7445.am2022-267.

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Abstract Background: Circulating tumor cells (CTCs) represent micrometastatic disease and may offer unique insights into future recurrences in lethal malignancies, including non-small cell lung cancer (NSCLC). Due to CTC rarity and limited stability, no CTC-derived xenograft (CDX) models have ever been generated from non-metastatic NSCLC patients directly. Alternative strategies are needed to molecularly characterize CTCs in this potentially curable patient group. Methods: Surgically resected NSCLC primary tumor tissues were implanted in immunodeficient mice to establish ten patient-derived xe

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Trevizani, Maria E., Katia K. Oliveira, Fabio A. Marchi, et al. "Abstract 2999: Evaluation of microRNA expression in metastatic and non-metastatic salivary gland mucoepidermoid carcinoma." Cancer Research 84, no. 6_Supplement (2024): 2999. http://dx.doi.org/10.1158/1538-7445.am2024-2999.

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Abstract Salivary gland tumors are a heterogeneous group of lesions, being mucoepidermoid carcinoma (MEC) the malignant neoplasm with the highest incidence, occurring mainly in the parotid gland. Characterization of its histological grade (high, intermediate, and low) is important for determining patient prognosis. Metastasis is more common high-grade tumors and can occur at regional lymph nodes or distant sites. Although the mechanisms underlying the metastatic process are largely unknown, large-scale microRNA expression profiling studies of human cancers have demonstrated that dysregulation

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Mulhauser, Kyler, Dario A. Marotta, Adam Gerstenecker, et al. "Capacity to consent to research participation in adults with metastatic cancer: comparisons of brain metastasis, non-CNS metastasis, and healthy controls." Neuro-Oncology Practice 7, no. 4 (2020): 439–45. http://dx.doi.org/10.1093/nop/npaa008.

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Abstract Background To evaluate the ability of individuals with metastatic cancer to provide informed consent to research participation, we used a structured vignette-based interview to measure 4 consenting standards across 3 participant groups. Methods Participants included 61 individuals diagnosed with brain metastasis, 41 individuals diagnosed with non-CNS metastasis, and 17 cognitively intact healthy controls. All groups were evaluated using the Capacity to Consent to Research Instrument (CCRI), a performance-based measure of research consent capacity. The ability to provide informed conse

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Esther, John, Umang Swami, Jonathan Chipman, et al. "Genomic alterations in visceral versus nonvisceral “metastatic” site tumor tissue in metastatic prostate cancer (mPC)." Journal of Clinical Oncology 38, no. 6_suppl (2020): 167. http://dx.doi.org/10.1200/jco.2020.38.6_suppl.167.

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167 Background: Men with mPC with visceral metastasis, as compared to non-visceral disease have inferior outcomes regardless of therapy (PMID: 25403629). Herein, we hypothesize that visceral versus non-visceral metastasis sites differ with regards to underlying genomic alterations (GA). These GA possibly drive metastasis to visceral sites and mediate a more aggressive disease. Identifying these GA may guide future trial designs by better stratifying patients and predicting therapy responses. Methods: In this retrospective analysis, inclusion criteria were: diagnosis of mPC and comprehensive ge

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Bilgin, Emre, Gülüzar Atli, Berna B. Duman, and Ali I. Okten. "Evaluation of Oxidative Stress Biomarkers in Brain Metastatic and Non-Metastatic Lung Cancer Patients with Different Cell Types." Anti-Cancer Agents in Medicinal Chemistry 21, no. 15 (2021): 2032–40. http://dx.doi.org/10.2174/1871520621666210211163055.

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Background: Oxidative stress that leads to an imbalanced prooxidant/antioxidant status can be a critical factor affecting lung cancer etiopathology. The antioxidant system provides primary protection under oxidative stress. Objective: The purpose of the study was to investigate the serum antioxidant system status in brain metastatic and non-metastatic lung cancer patients with different cell types. Methods: In this prospective study, 33 patients with lung cancer metastasis (metastatic patient group), 36 lung cancer patients (non-metastatic patient group), and 25 healthy control groups were inc

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Liu, Manlu, Yanlong Zhu, Sean J. McIlwain, et al. "Characterizing Plasma-Based Metabolomic Signatures for Metastasis in Non-Small Cell Lung Cancer." Metabolites 15, no. 5 (2025): 340. https://doi.org/10.3390/metabo15050340.

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Background/Objectives: The current staging of non-small cell lung cancer (NSCLC) relies on conventional imaging, which lacks the sensitivity to detect micrometastatic disease. The functional assessment of NSCLC progression may provide independent information to enhance the prediction of metastatic risk. The objective of this study was to determine if we could identify a metabolomic signature predictive of metastasis in patients with NSCLC treated with definitive radiation. Methods: Plasma samples were collected prospectively from patients enrolled in a clinical trial with non-metastatic NSCLC

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Suryawisesa, Ida Bagus Made, and Ida Bagus Tjakra Wibawa Manuaba. "Overexpression of Mammaglobin-A in Primary Breast Tissue Tumor and High Concentration of mRNA Mammaglobin-A in Peripheral Blood as Risk Factors for Metastatic Breast Cancer." Asian Pacific Journal of Cancer Biology 9, no. 2 (2024): 129–35. http://dx.doi.org/10.31557/apjcb.2024.9.2.129-135.

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Objective: There is still limited evidence for the use of biomarkers in breast cancer. However, mammaglobin-A in tissue and blood has recently been found as a promising biomarker for detecting metastases. Therefore, this study will examine the overexpression of mammaglobin-A in primary breast tissue tumors and the elevated concentration of mammaglobin-A messenger RNA (mRNA0 in peripheral blood as potential risk factors for breast cancer metastasis. Methods: The study was conducted at Sanglah General Hospital in Bali, Indonesia, from July 2017 to March 2018. It employed a hybrid research design

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Murakami, Takashi, Hiroaki Shimizu, Hiroyuki Nojima, et al. "Diffusion-Weighted Magnetic Resonance Imaging for the Diagnosis of Lymph Node Metastasis in Patients with Biliary Tract Cancer." Cancers 16, no. 18 (2024): 3143. http://dx.doi.org/10.3390/cancers16183143.

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Objective: The diagnostic efficacy of the apparent diffusion coefficient (ADC) in diffusion-weighted magnetic resonance imaging (DW-MRI) for lymph node metastasis in biliary tract cancer was investigated in the present study. Methods: In total, 112 surgically resected lymph nodes from 35 biliary tract cancer patients were examined in this study. The mean and minimum ADC values of the lymph nodes as well as the long-axis and short-axis diameters of the lymph nodes were assessed by computed tomography (CT). The relationship between these parameters and the presence of histological lymph node met

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Rosmiati, Besse, Uleng Bahrun, and Ruland DN Pakasi. "MATRIKs METALOPROTEINASE-2 DI METASTASIS KARSINOMA PAYUDARA (Matrix Metalloproteinase-2 In Breast Cancer Metastastis)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 21, no. 1 (2018): 11. http://dx.doi.org/10.24293/ijcpml.v21i1.1251.

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Matrix Metalloproteinase-2 is a family of extra cellular matrix degrading proteinases. Study results on the role of MMP-2 in breastcancer progression and metastasis are still controversial. The aim of this study was to know the MMP-2 level by analyzing in metastaticand non metastatic breast cancer patients by using a cross sectional design, it was carried out in the Wahidin Sudirohusodo, Ibnu Sina,Labuang Baji Hospitals and at the Research Unit of UNHAS Makassar from April 2012 until June 2012. The 56 breast cancer patientswere divided into two groups: metastatic and non metastatic based on th

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Tunset, Hanna Maja, Astrid Jullumstrø Feuerherm, Linn-Karina Myrland Selvik, Berit Johansen, and Siver Andreas Moestue. "Cytosolic Phospholipase A2 Alpha Regulates TLR Signaling and Migration in Metastatic 4T1 Cells." International Journal of Molecular Sciences 20, no. 19 (2019): 4800. http://dx.doi.org/10.3390/ijms20194800.

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Metastatic disease is the leading cause of death in breast cancer patients. Disrupting the cancer cell’s ability to migrate may be a strategy for hindering metastasis. Cytosolic phospholipase A2 α (cPLA2α), along with downstream proinflammatory and promigratory metabolites, has been implicated in several aspects of tumorigenesis, as well as metastasis, in various types of cancer. In this study, we aim to characterize the response to reduced cPLA2α activity in metastatic versus non-metastatic cells. We employ an isogenic murine cell line pair displaying metastatic (4T1) and non-metastatic (67NR

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Patel, Pretesh R., David S. Yoo, Yuzuru Niibe, James J. Urbanic, and Joseph K. Salama. "A Call for the Aggressive Treatment of Oligometastatic and Oligo-Recurrent Non-Small Cell Lung Cancer." Pulmonary Medicine 2012 (2012): 1–7. http://dx.doi.org/10.1155/2012/480961.

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Metastatic non-small cell lung cancer (NSCLC) carries a dismal prognosis. Clinical evidence suggests the existence of an intermediate, or oligometastatic, state when metastases are limited in number and/or location. In addition, following initial curative therapy, many patients present with limited metastatic disease, or oligo-recurrence. Metastasis-directed, anti-cancer therapies may benefit these patients. A growing evidence-base supports the use of hypofractionated, image-guided radiotherapy (HIGRT) for a variety of malignant conditions including inoperable stage I NSCLC and many metastatic

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Carrie, C., C. Mottolese, E. Bouffet, et al. "Non-metastatic childhood ependymomas." Radiotherapy and Oncology 36, no. 2 (1995): 101–6. http://dx.doi.org/10.1016/0167-8140(95)01605-g.

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Kargi, H. Aydanur, M. Fatih Kuyucuoğlu, Mehmet Alakavuklar, Oya Akpmar, and Saffet Erk. "CD44 expression in metastatic and non-metastatic non-small cell lung cancers." Cancer Letters 119, no. 1 (1997): 27–30. http://dx.doi.org/10.1016/s0304-3835(97)00254-1.

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Ijaz, Sardar H., Amro Aglan, Sanober Nusrat, Areeba Shahnawaz, and Douglas A. Drevets. "Non-Small Cell Lung Cancer Presenting as Anterior Nasal Mass and Epistaxis." Journal of Investigative Medicine High Impact Case Reports 11 (January 2023): 232470962211506. http://dx.doi.org/10.1177/23247096221150633.

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Lung malignancy presentation with an uncommon metastatic site is a diagnostic challenge and often associated with poor prognosis. Nasal cavity is a rare metastatic site for any type of lung cancer. We report an unusual case of poorly differentiated adenosquamous carcinoma of the lung with widespread metastasis presenting as a right vestibular nasal mass with epistaxis. A 76-year-old male patient with chronic obstructive pulmonary disease and 80 pack-year smoking history presented with spontaneous epistaxis. He reported a new rapidly growing right-sided nasal vestibular mass first noticed 2 wee

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Oh, William K., Stephanie Doctor, James H. Godbold, Matt D. Galsky, and Che-Kai Tsao. "Evolving patterns of metastatic disease in castration-resistant prostate cancer (CRPC) reported in clinical trials from 1990 to 2011." Journal of Clinical Oncology 31, no. 6_suppl (2013): 195. http://dx.doi.org/10.1200/jco.2013.31.6_suppl.195.

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195 Background: Bone remains the most common site of metastasis in CRPC. With new therapies extending survival in metastatic CRPC (mCRPC), we hypothesized that the incidence of non-osseous metastases is increasing over time. In this study, we evaluated the pattern of metastatic disease in mCRPC as reported in baseline characteristics of prospective clinical trials over 2 decades. Methods: We identified all therapeutic studies in patients with mCRPC in Pubmed and ASCO abstracts from 1990-2011. Inclusion criteria included phase 2 or 3 clinical trials in mCRPC with available baseline demographic

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Doctor, Stephanie, Che-Kai Tsao, James H. Godbold, Matt D. Galsky, and William K. Oh. "Evolving patterns of metastatic disease in castration-resistant prostate cancer (CRPC) reported in clinical trials from 1990 to 2011." Journal of Clinical Oncology 31, no. 15_suppl (2013): 5015. http://dx.doi.org/10.1200/jco.2013.31.15_suppl.5015.

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5015 Background: Bone remains the most common site of metastasis in CRPC. With new therapies extending survival in metastatic CRPC (mCRPC), we hypothesized that the incidence of non-osseous metastases is increasing over time. In this study, we evaluated the pattern of metastatic disease in mCRPC as reported in baseline characteristics of prospective clinical trials over 2 decades. Methods: We identified all therapeutic studies in patients with mCRPC in Pubmed and ASCO abstracts from 1990-2011. Inclusion criteria included phase 2 or 3 clinical trials in mCRPC with available baseline demographic

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Schell, Jonathan C., Steven B. Koenig, Kenneth Bastin, and William J. Wirostko. "Intracameral bevacizumab administered for non-small cell lung cancer metastasis to iris." Clinics and Practice 1, no. 2 (2011): 39. http://dx.doi.org/10.4081/cp.2011.e39.

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Ocular iris metastasis from lung cancer is uncommon. We report a patient with metastatic non-small cell lung cancer who was found to have a metastatic lesion to the iris. Local therapy for pain control and vision loss was administered with intracameral bevacizumab. Complete resolution of pain, improvement in vision, and near complete resolution of iris tumor were seen within two months. No ocular toxicity to anterior segment structures was detectable on corneal pachymetry and corneal specular microscopy. This is the first case report demonstrating safety and efficacy of intracameral bevacizuma

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Li, Qi, Qifan Zhang, Xiao Cheng, et al. "Next-Generation Sequencing Characterizes the Landscape of Somatic Mutations and Pathways in Metastatic Bile Tract Carcinoma." Journal of Oncology 2020 (September 4, 2020): 1–8. http://dx.doi.org/10.1155/2020/3275315.

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Purpose. Tumor metastasis remains the leading cause of cancer-related mortality in biliary tract cancer. The etiology and mechanism of bile tract carcinoma metastasis are unclear. Methods. The primary tumor and blood samples of 14 patients with biliary tract cancer were collected, followed by nucleic acid extraction and library construction. Target sequencing with 556 panel genes and WES were performed to detect the hot spot genes variations. Bioinformatics was used to comprehensively analyze the sequencing data of these samples, including the differences of tumor mutation burden and signaling

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Bae, Soong June, Ji Hyun Youk, Chang Ik Yoon, et al. "A nomogram constructed using intraoperative ex vivo shear-wave elastography precisely predicts metastasis of sentinel lymph nodes in breast cancer." European Radiology 30, no. 2 (2019): 789–97. http://dx.doi.org/10.1007/s00330-019-06473-5.

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Abstract Objective To develop a nomogram and validate its use for the intraoperative evaluation of nodal metastasis using shear-wave elastography (SWE) elasticity values and nodal size Methods We constructed a nomogram to predict metastasis using ex vivo SWE values and ultrasound features of 228 axillary LNs from fifty-five patients. We validated its use in an independent cohort comprising 80 patients. In the validation cohort, a total of 217 sentinel LNs were included. Results We developed the nomogram using the nodal size and elasticity values of the development cohort to predict LN metastas

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Tian, Yanhua, Jian-Rong Li, Bo Zhu, et al. "Abstract 1300: Single-cell and spatial transcriptomic profiling reveal the cascade of immune events during progression and metastasis of non-small cell lung cancer." Cancer Research 83, no. 7_Supplement (2023): 1300. http://dx.doi.org/10.1158/1538-7445.am2023-1300.

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Abstract Introduction: Lung cancer is the leading cause of cancer-related deaths worldwide and metastasis accounts for 90% of cancer-related mortality. A better understanding of the cascade of molecular and immune events underlying evolution during tumor progression and metastasis may help develop new strategies to prevent and treat metastasis more effectively. Methods: In this study, we utilized two mouse models of metastatic lung cancer: a genetically engineered mouse model (GEMM) with mutant Kras and Trp53 (KP, KrasLSL-G12D/+; Trp53fl/fl), which forms lung adenocarcinoma with high metastati

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Sikora-Kupis, Bożena. "Apalutamid for treatment of nonmetastatic castration-resistant prostste cancer – case study." OncoReview 13, no. 1(49) (2023): 6–8. http://dx.doi.org/10.24292/01.or.131319323.

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A special form of prostate cancer is non-metastatic castration-resistant prostate cancer. Patients with this form have rising prostate-specific antigen and castrate testosterone levels, with no radiological findings of metastatic disease on computed tomography and bone scan. The phase III trials demonstrated apalutamide, darolutamide or enzalutamide to be associated with a significantly longer median metastasis-free survival. The featured description presents one case of man with non-metastatic castration- resistant prostate cancer who was treated with apalutamide.

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Deyell, Matthew, Christopher S. Garris, and Ashley M. Laughney. "Cancer metastasis as a non-healing wound." British Journal of Cancer 124, no. 9 (2021): 1491–502. http://dx.doi.org/10.1038/s41416-021-01309-w.

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AbstractMost cancer deaths are caused by metastasis: recurrence of disease by disseminated tumour cells at sites distant from the primary tumour. Large numbers of disseminated tumour cells are released from the primary tumour, even during the early stages of tumour growth. However, only a minority survive as potential seeds for future metastatic outgrowths. These cells must adapt to a relatively inhospitable microenvironment, evade immune surveillance and progress from the micro- to macro-metastatic stage to generate a secondary tumour. A pervasive driver of this transition is chronic inflamma

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Dogan, Ender, Sedat Tarik Firat, Muhammet Cengiz, Oktay Bozkurt, Mevlude Inanc, and Metin Ozkan. "The Role of Clinicopathological Features in Tyrosine Kinase Inhibitory Duration in EGFR Mutant Metastatic Non-Small Cell Lung Cancer." Journal of Clinical Medicine 14, no. 4 (2025): 1149. https://doi.org/10.3390/jcm14041149.

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Background: Epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) are effective treatments for EGFR mutant (EGFRm) metastatic non-small cell lung cancer (mNSCLC). However, the benefit of EGFR-TKIs varies. We aimed to determine the impact of clinicopathological features on the duration of response to EGFR-TKIs in EGFRm mNSCLC. Method: Patients diagnosed with EGFRm mNSCLC who underwent EGFR-TKI therapy were retrospectively reviewed. Cox regression analyses were employed to determine the association between the PFS rates of EGFR-TKI treatments and the clinicopathological variabl

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Park, Hyung Kyu. "Neuroendocrine Carcinomas of the Uterine Cervix, Endometrium, and Ovary Show Higher Tendencies for Bone, Brain, and Liver Organotrophic Metastases." Current Oncology 29, no. 10 (2022): 7461–69. http://dx.doi.org/10.3390/curroncol29100587.

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Neuroendocrine carcinoma (NEC) of the female genital tract is a rare and aggressive subtype of cancer that is still poorly understood. Several recent studies reported that pulmonary and gastroenteropancreatic neuroendocrine neoplasms show significantly different patterns of metastasis compared to non-NECs of the same primary sites. The aim of this study was to evaluate the metastatic patterns of gynecologic NECs and to compare the metastatic patterns of NECs and non-NECs of the same primary sites. We retrieved and analyzed cervical, endometrial, and ovarian NEC cases from the Surveillance, Epi

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Zhu, Wanfang, Wenxin Qian, Wenting Liao, et al. "Non-Invasive and Real-Time Monitoring of the Breast Cancer Metastasis Degree Via Metabolomics." Cancers 14, no. 22 (2022): 5589. http://dx.doi.org/10.3390/cancers14225589.

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Breast cancer (BC) is a serious threat to women’s health and metastasis is the major cause of BC-associated mortality. Various techniques are currently used to preoperatively describe the metastatic status of tumors, based on which a comprehensive treatment protocol was determined. However, accurately staging a tumor before surgery remains a challenge, which may lead to the miss of optimal treatment options. More severely, the failure to detect and remove occult micrometastases often causes tumor recurrences. There is an urgent need to develop a more precise and non-invasive strategy for the d

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Mardiah, Ainul, Hendra Susanto та Sri Rahayu Lestari. "TGF-β and SMAD2/4 Expression in Nonmetastatic and Metastatic Colorectal Cancer Patients". BIO Web of Conferences 117 (2024): 01001. http://dx.doi.org/10.1051/bioconf/202411701001.

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Colorectal cancer (CRC) is the third most common and second cancer with the highest mortality rate in the world. The leading cause of death in colorectal cancer patients is cancer that has metastasized, with the most common site of metastasis being the liver. One of the signaling that regulates malignancy of cancer cells is TGF-β/Smad. Through activation of the Smad2/3/4, TGF-β regulates the EMT Transcription factors to activate Epithelial Mesenchymal Transition (EMT) program. Tumor cells that have undergone EMT have migratory, invasive, and metastatic phenotypes. This study aims to know the d

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Abbastabar, Maryam, Heike Allgayer, Mahdi Sepidarkish, et al. "Expression Status of Rap1 Pathway-Related Genes in Liver Metastases Compared with Corresponding Primary Colorectal Cancer." Cancers 16, no. 1 (2023): 171. http://dx.doi.org/10.3390/cancers16010171.

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Understanding molecular networks of CRLM is an ongoing area of research. In this study, paired CRC tissue and adjacent noncancerous tissue from 15 non-metastatic CRC patients and paired CRC tissue and matched liver metastatic tissues from 15 CRLM patients along with their adjacent noncancerous tissues were evaluated. We assessed Rap1 pathway-related genes including NRAS, FGF-1, NGF, and KDR expression by qRT-PCR and their protein status by Western blot. In CRLM patients, NRAS, FGF1, and KDR mRNA and protein were expressed at higher levels in metastatic than in CRC primary tumor and adjacent no

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Rashed, LA, SH Faiz, MA Hassan, MM Elsebaie, and AE Saad. "Circulating Micro RNA 181A as Biomarker in Breast Cancer, Its Possible Association with Metastasis & Epithelial Mesenchymal Transformation." Tumori Journal 106, no. 1_suppl (2020): 3. http://dx.doi.org/10.1177/0300891620914122.

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Background: Recent studies have reported the involvement of micro RNA 181a in diverse cellular functions. Though some studies have shown that miR-181a expression is downregulated in several human solid tumors, others have demonstrated that upregulation of miR-181a may promote metastasis and invasion of human cancers. Aim of the Study: The aim of this work is to detect the level of circulating miRNA-181a in breast cancer cases at different stages and to study its role in metastasis & epithelial mesenchymal transformation (EMT) through the possible association between miRNA 181a and transfor

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Slotman, B. J., K. H. Njo, A. de Jonge, O. W. M. Meijer, and A. B. M. F. Karim. "Palliative radiotherapy in advanced metastatic and non-metastatic non-small cell lung cancer." Lung Cancer 8, no. 5-6 (1993): 285–92. http://dx.doi.org/10.1016/0169-5002(93)90477-f.

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Atjo, Sriwati, Uleng Bahrun, and Hardjoeno Hardjoeno. "ANALISIS KADAR SERUM FERITIN DI KARSINOMA PAYUDARA (Analysis of Ferritin Levels in Carcinoma Mammae)." INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY 22, no. 1 (2018): 34. http://dx.doi.org/10.24293/ijcpml.v22i1.1219.

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Carcinoma Mammae is a malignant disease originating from mammary parenchyma, and the second largest cause of death inthe world. Ferritin is a marker of neoplasia, which levels are increased in non-metastatic carcinoma mammae and more increased inmetastatic carcinoma mammae. This cross sectional study was conducted during June 2012 in carcinoma mammae patients of theWahidin Sudirohusodo Hospital, Ibnu Sina Hospital and Labuang Baji Hospital in Makassar. The aim of this study was to know theserum ferritin levels in metastatic and non-metastatic carcinoma mammae. In this study, 56 samples were ob

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Chao, Ce, Yongxiang Qian, Xihao Li, Chen Sang, Bin Wang, and Xiao-ying Zhang. "Surgical Survival Benefits With Different Metastatic Patterns for Stage IV Extrathoracic Metastatic Non-Small Cell Lung Cancer: A SEER-Based Study." Technology in Cancer Research & Treatment 20 (January 1, 2021): 153303382110330. http://dx.doi.org/10.1177/15330338211033064.

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Background: With the knowledge of oligometastases, primary surgery plays an increasingly vital role in metastatic non-small cell lung cancer. We aimed to evaluate the survival benefit of primary surgery based on metastatic patterns. Materials and Methods: The selected patients with stage IV extrathoracic metastatic (m1b) non-small cell lung cancer between 2010 and 2015 were included in a retrospective cohort study from the Surveillance, Epidemiology, and End Results (SEER) database. Multiple imputation was used for the missing data. Patients were divided into 2 groups depending on whether surg

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Dai, Jindong, Xu Hu, Haoran Zhang, et al. "The survival benefit of metastasectomy for metastatic non-clear cell renal cell carcinoma." Journal of Clinical Oncology 41, no. 6_suppl (2023): 686. http://dx.doi.org/10.1200/jco.2023.41.6_suppl.686.

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686 Background: A subset of patients with metastatic clear cell renal cell carcinoma (ccRCC) might benefit from metastasectomy, while those with metastatic non-clear cell carcinoma (non-ccRCC) might be potential candidates for metastasectomy remains unclear. Methods: From the metastatic RCC database of West China Hospital, a total of 114 patients with confirmed metastatic non-ccRCC were identified. Patients were divided into groups by systemic therapy plus nephrectomy and metastasectomy or systemic therapy plus nephrectomy alone. Clinical outcomes included overall survival (OS) and progression

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Demeda, Clarissa Favero, Cyntia Helena Pereira de Carvalho, Ana Rafaela Luz de Aquino, Cassiano Francisco Weege Nonaka, Lélia Batista de Souza, and Leão Pereira Pinto. "Expression of Glucose Transporters 1 and 3 in Metastatic and Non-Metastatic Lower Lip Squamous Cell Carcinoma." Brazilian Dental Journal 25, no. 5 (2014): 372–78. http://dx.doi.org/10.1590/0103-6440201300054.

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This study aimed to evaluate the immunoexpression of glucose transporters 1 (GLUT-1) and 3 (GLUT-3) in metastatic and non-metastatic lower lip squamous cell carcinoma (LLSCC). Twenty LLSCCs with regional nodal metastasis and 20 LLSCCs without metastasis were selected. The distribution of staining and the percentage of GLUT-1 and GLUT-3 staining in each tumor core and at the deep invasive front were assessed. Most tumors (70%) exhibited peripheral staining for GLUT-1 in nests, sheets and islands of neoplastic cells, whereas predominantly central staining was observed for GLUT-3 (72.5%). A high

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Yue, Jian, Jing Wang, Wei Chen, Xuedong Yin, Huimin Du, and Yuxian Wei. "Palliative surgery versus non-surgery of the solitary metastatic lesion in De novo metastatic breast cancer: A SEER based study." Medicine 103, no. 25 (2024): e38651. http://dx.doi.org/10.1097/md.0000000000038651.

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This study aimed to evaluate whether palliative surgery for metastatic lesion could provide a survival benefit in metastatic breast cancer (MBC) patients with solitary metastasis. De novo MBC patients with solitary distant lesions were enrolled utilizing the Surveillance, Epidemiology, and End Results (SEER) database. Propensity score matching (PSM) was conducted to form matched pairs of the surgery group and the non-surgery group. The breast cancer-specific survival (BCSS) and overall survival (OS) outcomes between the 2 groups were compared in the following 3 sample models: the entire cohort

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Beylerli, Ozal, Ilgiz F. Gareev, and Aferin Beilerli. "Long non-coding RNAs and their role in metastasis." HERALD of North-Western State Medical University named after I.I. Mechnikov 11, no. 2 (2019): 91–97. http://dx.doi.org/10.17816/mechnikov201911291-97.

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Cancer metastasis is a multistep process in which cancer cells leave the primary focus, survive in the bloodstream, and colonize in a distant organ. This is the main cause of cancer morbidity and mortality. It is mediated by a multistep process called the metastatic cascade. Initial steps include local invasion and migration, angiogenesis, epithelial-mesenchymal transition (EMF) and intravasation. Non-coding RNAs represent a large part of the transcriptome, with long non-coding RNAs (lncRNAs) constituting a large proportion. The perception of long non-coding RNAs as fragments of RNA and transc

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Adiputra, Putu Anda Tusta, I. Wayan Sudarsa, Gede Budhi Setiawan, Ida Bagus Made Suryawisesa, and Kadek Yudi Fajar Mahendra. "Strong Mammaglobin-A Expression in Tumor Tissue as a Risk Factor for Metastasis in Balinese Breast Cancer Patients." Biomedical and Pharmacology Journal 17, no. 4 (2024): 2431–36. https://doi.org/10.13005/bpj/3035.

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Mammaglobin (hMAG) is a secretory protein (secretoglobin) essential for tumor growth. The molecular mechanisms of hMGB-A-regulated growth include the expression and activation of various Mitogen-Activated Protein Kinase (MAPK) pathways. Elevated hMAG signifies metastatic breast cancer and primary breast cancer compared to non-malignant breast tissue. This study aimed to prove the relationship between mammaglobin A expression and metastasis at Prof. I.G.N.G. Ngoerah Hospital Bali. This is an observational study with a case-control design, conducted in the Oncology Department of Prof. I.G.N.G. N

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Bais, Manish V., Maria Kukuruzinska, and Philip C. Trackman. "Orthotopic non-metastatic and metastatic oral cancer mouse models." Oral Oncology 51, no. 5 (2015): 476–82. http://dx.doi.org/10.1016/j.oraloncology.2015.01.012.

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Abdurahman, Maman, Dimyati Achmad, Pisi Lukitto, and Bethy Hernowo. "E-Cadherin in Metastatic and Non Metastatic Breast Carcinoma." Breast 20 (October 2011): S29. http://dx.doi.org/10.1016/j.breast.2011.08.049.

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Ghosal, Suman. "Long Intergenic Non Coding RNA and MicroRNA Profiles of Pheochromocytoma and Paraganglioma as Prognostic Biomarkers." Journal of the Endocrine Society 5, Supplement_1 (2021): A1024. http://dx.doi.org/10.1210/jendso/bvab048.2096.

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Abstract microRNAs (miRNAs) and long intergenic noncoding RNAs (lincRNAs) have been reported as important markers for many cancers. In search of new markers for the metastatic or aggressive phenotypes in the neuroendocrine tumor pheochromocytomas and paragangliomas (PCPG), we analyzed the non-coding transcriptome from patient gene expression data in The Cancer Genome Atlas. We used differential expression analysis and an elastic-net machine-learning model to identify miRNA and lincRNA transcriptomic signature specific to PCPG molecular subtypes. Similarly, miRNAs and lincRNAs specific to aggre

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Su, Chloe C., Julie T. Wu, Eunji Choi, et al. "Overall Survival Among Patients With De Novo Stage IV Metastatic and Distant Metastatic Recurrent Non–Small Cell Lung Cancer." JAMA Network Open 6, no. 9 (2023): e2335813. http://dx.doi.org/10.1001/jamanetworkopen.2023.35813.

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ImportanceDespite recent breakthroughs in therapy, advanced lung cancer still poses a therapeutic challenge. The survival profile of patients with metastatic lung cancer remains poorly understood by metastatic disease type (ie, de novo stage IV vs distant recurrence).ObjectiveTo evaluate the association of metastatic disease type on overall survival (OS) among patients with non–small cell lung cancer (NSCLC) and to identify potential mechanisms underlying any survival difference.Design, Setting, and ParticipantsCohort study of a national US population based at a tertiary referral center in the

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Shin, Sol-Bi, Hay-Ran Jang, Rong Xu, Jae-Yeon Won та Hyungshin Yim. "Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancer". Oncogene 39, № 4 (2019): 767–85. http://dx.doi.org/10.1038/s41388-019-1023-z.

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Abstract Early findings that PLK1 is highly expressed in cancer have driven an exploration of its functions in metastasis. However, whether PLK1 induces metastasis in vivo and its underlying mechanisms in NSCLC have not yet been determined. Here, we show that the expression of active PLK1 phosphorylated at T210, abundant in TGF-β-treated lung cells, potently induced metastasis in a tail-vein injection model. Active PLK1 with intact polo-box and ATP-binding domains accelerated cell motility and invasiveness by triggering EMT reprogramming, whereas a phosphomimetic version of p-S137-PLK1 did not

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Wu, Anqing, Jiaxin Tang, Ziyang Guo, et al. "Long Non-Coding RNA CRYBG3 Promotes Lung Cancer Metastasis via Activating the eEF1A1/MDM2/MTBP Axis." International Journal of Molecular Sciences 22, no. 6 (2021): 3211. http://dx.doi.org/10.3390/ijms22063211.

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The occurrence of distant tumor metastases is a major barrier in non-small cell lung cancer (NSCLC) therapy, and seriously affects clinical treatment and patient prognosis. Recently, long non-coding RNAs (lncRNAs) have been demonstrated to be crucial regulators of metastasis in lung cancer. The aim of this study was to reveal the underlying mechanisms of a novel lncRNA LNC CRYBG3 in regulating NSCLC metastasis. Experimental results showed that LNC CRYBG3 was upregulated in NSCLC cells compared with normal tissue cells, and its level was involved in these cells’ metastatic ability. Exogenously

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Bommireddy, Ramireddy, Ashwathi P. Menon, Luis E. Munoz, et al. "Efficacy of immunotherapy approaches in metastatic and non-metastatic lung cancer models." Journal of Immunology 200, no. 1_Supplement (2018): 181.16. http://dx.doi.org/10.4049/jimmunol.200.supp.181.16.

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Abstract Lung cancer is the leading cause of cancer related deaths accounting for approximately 30% of all cancer related mortalities affecting both men and women. Currently, there is no cure for the common non-small cell lung cancer (NSCLC) thus development of efficacious therapies is urgently needed. In this study, we investigate the efficacy of tumor membrane-based vaccine immunotherapy and immune checkpoint blockade antibodies in an aggressive, non-metastatic, immune checkpoint inhibitor resistant lung cancer model (LL/2) and a highly metastatic lung cancer (CMT-167) model. LL/2 and CMT-16

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