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Journal articles on the topic 'Non-Pharmacological OCD Treatment'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Franz, Adelar Pedro, Mariana Paim, Rafael Moreno de Araújo, et al. "Treating refractory obsessive-compulsive disorder: what to do when conventional treatment fails?" Trends in Psychiatry and Psychotherapy 35, no. 1 (2013): 24–35. http://dx.doi.org/10.1590/s2237-60892013000100004.

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Obsessive-compulsive disorder (OCD) is a chronic and impairing condition. A very small percentage of patients become asymptomatic after treatment. The purpose of this paper was to review the alternative therapies available for OCD when conventional treatment fails. Data were extracted from controlled clinical studies (evidence-based medicine) published on the MEDLINE and Science Citation Index/Web of Science databases between 1975 and 2012. Findings are discussed and suggest that clinicians dealing with refractory OCD patients should: 1) review intrinsic phenomenological aspects of OCD, which

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Dhivya, K., and Bibila Samuel. "A Systematic Review on Comparison of Deep Brain Stimulation (DBS) and Transcranial Magnetic Stimulation (TMS) in the Treatment of Refractory Obsessive Compulsive Disorder (OCD)." Journal of Drug Delivery and Therapeutics 13, no. 7 (2023): 161–71. http://dx.doi.org/10.22270/jddt.v13i7.6126.

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The Diagnostic and Statistical Manual of mental disorders (DSM 4) defines obsessive compulsive disorder (OCD) as compulsive or repetitive behaviors of obsessions that a person feels driven to perform. These acts and behaviors are aimed at preventing or reducing distress but are not connected in a realistic way. OCD is a pathological hypothesis of dysfunctions occurring within the cortico-striato-thalamo-cortical loops. It is one of the most prevalent and disabling psychiatric disorder associated with decreased life quality (American Psychiatric Association). This article will provide a brief s

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Truong, Thanh Phuong Anh, Briana Applewhite, Annie Heiderscheit, and Hubertus Himmerich. "A Systematic Review of Scientific Studies and Case Reports on Music and Obsessive-Compulsive Disorder." International Journal of Environmental Research and Public Health 18, no. 22 (2021): 11799. http://dx.doi.org/10.3390/ijerph182211799.

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Obsessive-compulsive disorder (OCD) is a severe psychiatric disorder, which can be associated with music-related symptoms. Music may also be used as an adjunct treatment for OCD. Following the PRISMA guidelines, we performed a systematic literature review exploring the relationship between music and OCD by using three online databases: PubMed, the Web of Science, and PsycINFO. The search terms were “obsessive compulsive disorder”, “OCD”, “music”, and “music therapy”. A total of 27 articles were utilised (n = 650 patients/study participants) and grouped into three categories. The first category

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Stobie, Blake, Tracey Taylor, Alexandra Quigley, Sandra Ewing, and Paul M. Salkovskis. "“Contents May Vary”: A Pilot Study of Treatment Histories of OCD Patients." Behavioural and Cognitive Psychotherapy 35, no. 3 (2007): 273–82. http://dx.doi.org/10.1017/s135246580700358x.

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Definitions of treatment failure and the labelling of patients as non-responsive typically require treatments to have been offered and failed. For pharmacological treatments, treatment quality is relatively easy to define; this is much more difficult with psychological treatments. This study examined patient recollections of previous therapy for obsessive compulsive disorder (OCD). A Treatment History Questionnaire was administered to a sample of 57 apparently treatment refractory OCD patients from a specialist national OCD treatment unit and a national charity for OCD sufferers. On average, r

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Eda, Gorbis. "Mindfulness-based Behavioral Therapy (MBBT) for OCD." Japan Journal of Medical Science Eda 05, no. 01 (2024): 03. https://doi.org/10.5281/zenodo.13888734.

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Abstract OCD is a widespread disorder affecting about 1.21% or 3.3 million people in the US alone. Despite the relative benefits of pharmacological interventions and cognitive-behavior therapy, the full recovery rate is low, and dropout and relapse rates are high. Apart from the standard outpatient Exposure and Response Prevention (ERP) method, other options for severe, refractory OCD include general psychiatric inpatient admission, intensive residential treatment, and partial-hospitalization. None of these options is completely or universally effective, and there is a need for continued innov

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Rück, Christian, Lina Lundström, Oskar Flygare, et al. "Study protocol for a single-blind, randomised controlled, non-inferiority trial of internet-based versus face-to-face cognitive behaviour therapy for obsessive–compulsive disorder." BMJ Open 8, no. 9 (2018): e022254. http://dx.doi.org/10.1136/bmjopen-2018-022254.

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IntroductionExpert guidelines recommend cognitive–behavioural therapy (CBT) as a first-line treatment for obsessive–compulsive disorder (OCD), but the majority of patients with OCD do not have access to CBT. Internet-delivered CBT (ICBT) has the potential to make this evidence-based treatment more accessible while requiring less therapist time than traditional face-to-face (f2f) CBT. Data from six clinical trials suggest that ICBT for OCD is both efficacious and cost-effective, but whether ICBT is non-inferior to traditional f2f CBT for OCD is yet unknown.Methods and analysisA single-blind, ra

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Fullana, M. A., P. Alonso, M. Gratacòs, et al. "Variation in the BDNF Val66Met polymorphism and response to cognitive-behavior therapy in obsessive-compulsive disorder." European Psychiatry 27, no. 5 (2012): 386–90. http://dx.doi.org/10.1016/j.eurpsy.2011.09.005.

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AbstractBackgroundRecent research suggests that the brain-derived neurotrophic factor (BDNF) may play a role in extinction learning. The goal of this study was to test whether variation in the BDNF Val66Met polymorphism is related to treatment response to exposure-based cognitive-behavior therapy (CBT), a form of extinction learning, in obsessive-compulsive disorder (OCD).MethodsOne hundred and six OCD patients from a specialized clinic, who underwent a standardized CBT treatment after partial or non-response to a 12-week pharmacological trial, were genotyped for the BDNF Val66Met and the rela

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Hansen, Elsebet S., Leslie S. Prichep, Tom G. Bolwig, and E. Roy John. "Quantitative Electroencephalography in OCD Patients Treated with Paroxetine." Clinical Electroencephalography 34, no. 2 (2003): 70–74. http://dx.doi.org/10.1177/155005940303400205.

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The effectiveness of drugs that have a specific effect on the activity of the serotonergic neurotransmitter system has changed the outlook for patients suffering from obsessive-compulsive disorder (OCD). With a response rate of about 70% to such compounds and the great amount of brain imaging studies conducted over the past decades, an understanding of the biochemical nature and origins of OCD is beginning to unfold. Convergent data including ethological and experimental observations, clinico-pathological findings and different imaging methods have implicated the basal ganglia along with the c

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Ivanova, Ekaterina, Robin Fondberg, Oskar Flygare, et al. "Study protocol for a single-blind, parallel-group, randomised, controlled non-inferiority trial of 4-day intensive versus standard cognitive behavioural therapy for adults with obsessive–compulsive disorder." BMJ Open 13, no. 12 (2023): e076361. http://dx.doi.org/10.1136/bmjopen-2023-076361.

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IntroductionIndividual cognitive behavioural therapy (CBT) with exposure and response prevention is an effective treatment for obsessive–compulsive disorder (OCD). However, individual CBT is costly and time-consuming, requiring weekly therapy sessions for 3–4 months. A 4-day intensive version of CBT for OCD delivered in group format has been recently developed in Norway (Bergen 4-day treatment, B4DT). B4DT has shown promising results in several uncontrolled and one small, randomised trial, but its non-inferiority to the gold standard treatment has not been established.Methods and analysisThis

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Martinotti, Giovanni, Stefania Chiappini, Mauro Pettorruso, et al. "Therapeutic Potentials of Ketamine and Esketamine in Obsessive–Compulsive Disorder (OCD), Substance Use Disorders (SUD) and Eating Disorders (ED): A Review of the Current Literature." Brain Sciences 11, no. 7 (2021): 856. http://dx.doi.org/10.3390/brainsci11070856.

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The obsessive–compulsive spectrum refers to disorders drawn from several diagnostic categories that share core features related to obsessive–compulsive disorder (OCD), such as obsessive thoughts, compulsive behaviors and anxiety. Disorders that include these features can be grouped according to the focus of the symptoms, e.g., bodily preoccupation (i.e., eating disorders, ED) or impulse control (i.e., substance use disorders, SUD), and they exhibit intriguing similarities in phenomenology, etiology, pathophysiology, patient characteristics and clinical outcomes. The non-competitive N-methyl-D-

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Mangas Palma, I., I. da Fonseca Pinto, J. Tavares Coelho, and R. Moreira. "Ketamine in the treatment of obsessive-compulsive disorder – a case report and literature review." European Psychiatry 67, S1 (2024): S631. http://dx.doi.org/10.1192/j.eurpsy.2024.1307.

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IntroductionObsessive-compulsive disorder (OCD) is a chronic condition characterized by time-consuming and distressing obsessions and/or compulsions, often accompanied by avoidance behaviours. It is a highly prevalent and incident disorder that results in considerable disability and quality of life reduction.Current pharmacological treatments are hindered by their delayed onset and the limited evidence on how to approach first and second line treatment-resistant patients.Recent research showcased the involvement of glutamatergic pathways in the pathophysiology of OCD prompting research into th

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Albert, Umberto, Gabriele Di Salvo, Francesca Solia, Gianluca Rosso, and Giuseppe Maina. "Combining Drug and Psychological Treatments for Obsessive- Compulsive Disorder: What is the Evidence, When and for Whom." Current Medicinal Chemistry 25, no. 41 (2019): 5632–46. http://dx.doi.org/10.2174/0929867324666170712114445.

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Background: Serotonin reuptake inhibitors (SRIs) and cognitive-behavioral psychotherapy (CBT) are first-line treatments for obsessive-compulsive disorder (OCD). Since response is often inadequate, in recent years researchers investigated whether combining CBT and SRIs, either ab initio or sequentially, results in a greater reduction of obsessivecompulsive symptoms. Objective: The aims of the present paper are to assess if combination treatment seems adding benefits as compared to either monotherapy alone and if sequential strategies may be effective in converting partial or non responders to a

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Bahman, Zohuri. "Augmenting Scalar Wave Vibration Energy and AI-Driven Therapies for Managing Obsessive-Compulsive Disorder (OCD)." Advance Medical and Clinical Research 06, no. 01 (2025): 04. https://doi.org/10.5281/zenodo.15239506.

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<strong>Abstract</strong> Obsessive-Compulsive Disorder (OCD) is a chronic and often debilitating mental health condition characterized by intrusive thoughts and repetitive behaviors that can significantly impair daily functioning and emotional well-being. While traditional treatments such as Cognitive Behavioral Therapy (CBT) and Selective Serotonin Reuptake Inhibitors (SSRIs) have shown effectiveness, they may not be sufficient or suitable for all individuals. This review explores an emerging, noninvasive therapeutic paradigm that combines scalar wave vibration energy wellness with Artificia

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Setién Preciados, P., E. Arroyo Sánchez, and C. Díaz Mayoral. "Body dysmorphia in a 23 year old patient with obsessive compulsive disorder: a case report." European Psychiatry 67, S1 (2024): S629. http://dx.doi.org/10.1192/j.eurpsy.2024.1304.

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IntroductionBody dysmorphic disorder (BDD) was considered an anxiety disorder in the DSM-IV, but in the DSM-V was added to the obsessive-compulsive and related disorders category. BDD is a psychiatric disorder characterised by an excessive, persistent, and distressful preoccupation with a perceived defect in appearance. These perceived defects are slight and are unnoticed by others. People with BDD usually have poor insight and are preoccupied with a perceived physical defect which causes them to check on it repeatedly. This leads to an impairment in psychosocial functioning, depression, and a

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Torbecke, Jonathan, Till Langhammer, Lisa Mewes, Ulrike Lueken, and Johannes Caspar Fendel. "Augmentation of cognitive-behavioural therapy for obsessive-compulsive and anxiety disorders: a protocol for a systematic review and meta-analysis." BMJ Open 14, no. 10 (2024): e090431. http://dx.doi.org/10.1136/bmjopen-2024-090431.

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IntroductionWhile cognitive-behavioural therapy (CBT) for obsessive-compulsive disorder (OCD) and anxiety disorders (ADs) has been proven to be effective and is commonly recommended, a considerable proportion of patients remain symptomatic, do not respond to treatment or discontinue it. Thus, augmentation strategies aimed at enhancing CBT outcomes are essential to reduce the burden of OCD and ADs on patients and society. Various augmentation strategies for CBT in OCD and ADs have been investigated, yet it remains unclear if they show robust beneficial effects beyond first-line CBT. With this s

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Ayub, Sher, and Hussain Ahmad. "Pattern of OCD Symptoms in Muslim Patients in Tertiary Care Hospital." BMC Journal of Medical Sciences 4, no. 2 (2023): 31–33. https://doi.org/10.70905/bmcj.04.02.0154.

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Objectives: To find the pattern of OCD symptoms in Muslim patients. Methodology: This study was conducted at the department of psychiatry Khalifa Gulnawaz Teaching Hospital Bannu, Pakistan from January 2022 to December 2022. Those who fulfilled the DSM criteria for obsessive compulsive disorder were included in the study. Those patients who were suffering from medical or neurological illness were excluded from the study. Results: Ninety-Five Muslim patients (68 males and 27 females) fulfilled the DSM criteria for obsessive compulsive disorder. The mean age of the group was 25.88+7.39. The main

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Sevda, Pinki, Surendra Singh Rajpurohit, Navratan Suthar, Charul Gupta, and Deepika Biyyala. "Antidepressant-Coincident Manic Episode in a Prepubertal Girl Presenting With Obsessive-Compulsive or Related Disorders: A Case Report." BJPsych Open 10, S1 (2024): S287—S288. http://dx.doi.org/10.1192/bjo.2024.685.

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AimsObsessive-Compulsive or Related Disorders (OCRDs) comprise a group of disorders characterized by repetitive thoughts and behaviours and are fairly less prevalent among children. The recommended treatment for OCRDs involves high doses of antidepressants, specifically selective serotonin reuptake inhibitors (SSRIs), along with non-pharmacological management. However, evidence suggests that the risk of inducing mania with antidepressants may be especially high in children and adolescents aged 14 years and younger.MethodsHere, we present a case of a nine-year girl, studying in fifth standard,

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Pourzitaki, Chryssa, Ioannis Dardalas, Frideriki Poutoglidou, Dimitrios Kouvelas, and Vasilios K. Kimiskidis. "The Combination of rTMS and Pharmacotherapy on In Vitro Models: A Mini-Review." CNS & Neurological Disorders - Drug Targets 19, no. 3 (2020): 220–26. http://dx.doi.org/10.2174/1871527319666200518100716.

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Background: Repetitive Transcranial Magnetic Stimulation (rTMS) is a non-invasive brain stimulation technique that is being actively explored as a potential therapeutic modality in various neuropsychiatric disorders, such as depression, neuropathic pain, epilepsy, multiple sclerosis, and neurodegenerative disorders, including the Parkinson’s and Alzheimer’s disease. The Food and Drug Administration (FDA) approved rTMS for the treatment of major depression, migraine-associated headaches, and Obsessive Compulsive Disorder (OCD). The fact that a significant proportion of patients suffering from t

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Ibrahim, Ismail A., Ahmed Hosney Nada, Nada Khalid Asar, et al. "A systematic review and meta-analysis for the efficacy of transcranial direct current stimulation (tDCS) in OCD treatment: A non-pharmacological approach to clinical interventions." Experimental Gerontology 196 (October 2024): 112551. http://dx.doi.org/10.1016/j.exger.2024.112551.

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Saradhadevi, S., and V. Hemavathy. "Effectiveness of sleep hygiene to reduce insomnia among persons with suffering with obsessive compulsive disorder-pilot analysis." CARDIOMETRY, no. 22 (May 25, 2022): 462–66. http://dx.doi.org/10.18137/cardiometry.2022.22.462466.

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Obsessive-compulsive disorder frequently have insomnia, and those with acute insomnia who also have mental comorbidities without therapy, they are more likely to develop persistent insomnia. We present a case of OCD with acute insomnia that was successfully treated with early non-pharmacological sleep psychiatry intervention. Sleep is necessary for brain function and the maintenance of cognitive and emotional processes. Insomnia and anxiety problems are common, and they’re linked to a lot of damage and disability. In addition to being strongly comorbid with major depressive illness, there is e

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Saradhadevi, S., and V. Hemavathy. "Effectiveness of sleep hygiene to reduce insomnia among persons with suffering with obsessive compulsive disorderpilot analysis." CARDIOMETRY, no. 22 (May 25, 2022): 484–88. http://dx.doi.org/10.18137/cardiometry.2022.22.484488.

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Obsessive-compulsive disorder frequently have insomnia, and those with acute insomnia who also have mental comorbidities without therapy, they are more likely to develop persistent insomnia. We present a case of OCD with acute insomnia that was successfully treated with early non-pharmacological sleep psychiatry intervention. Sleep is necessary for brain function and the maintenance of cognitive and emotional processes. Insomnia and anxiety problems are common, and they’re linked to a lot of damage and disability. In addition to being strongly comorbid with major depressive illness, there is e

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Roy, D. "Emetophobia (a specific phobia of vomiting): A case study." European Psychiatry 41, S1 (2017): S416—S417. http://dx.doi.org/10.1016/j.eurpsy.2017.01.367.

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IntroductionCase presentation of a young woman Ms. A.M., referred by her GP with an eating disorder, who was thereafter diagnosed with an uncommon type of phobia (emetophobia – a specific phobia of vomiting) and treated accordingly.ObjectivesTo highlight the diagnostic dilemma with such uncommon cases, who are often misdiagnosed as having anorexia nervosa or bulimia nervosa or suffering from other anxiety disorders (like OCD or GAD).MethodsA comprehensive mental state examination was conducted including a diagnostic clarification interview. She was followed up by the mental health team on a re

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Tatarinova, Tatiana V., Trina Deiss, Lorri Franckle, Susan Beaven, and Jeffrey Davis. "The Impact of MNRI Therapy on the Levels of Neurotransmitters Associated with Inflammatory Processes." International Journal of Molecular Sciences 21, no. 4 (2020): 1358. http://dx.doi.org/10.3390/ijms21041358.

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The neurotransmitter levels of representatives from five different diagnosis groups were tested before and after participation in the MNRI®—Masgutova Neurosensorimotor Reflex Intervention. The purpose of this study was to ascertain neurological impact on (1) Developmental disorders, (2) Anxiety disorders/OCD (Obsessive Compulsive Disorder), PTSD (Post-Traumatic Stress disorder), (3) Palsy/Seizure disorders, (4) ADD/ADHD (Attention Deficit Disorder/Attention Deficit Disorder Hyperactive Disorder), and (5) ASD (Autism Spectrum Disorder) disorders. Each participant had a form of neurological dysr

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Chiappini, S., R. Testa, F. Maisto, et al. "Compulsiveness dimension in a case of pathological gambling." European Psychiatry 33, S1 (2016): S294. http://dx.doi.org/10.1016/j.eurpsy.2016.01.999.

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IntroductionPathological gambling (PG) is currently included among Addictive Disorders (DSM-5). However, its phenomenology resembles features of Obsessive Compulsive Disorder. Several models of addiction conceptualize a progression from impulsivity to compulsivity transitioning from initial positive reinforcement motivations to later negative reinforcement and less pleasurable and automaticity mechanisms.Clinical presentationA 34-year-old male, since diagnosed with PG in 2013 and prescribed a group rehabilitation therapy, presented in 2015 complaining of intrusive thoughts and depression sympt

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Selvi, Y., L. Besiroglu, A. Aydin, A. Atli, and M. Gulec. "Influence of pharmacological treatment on obsessive beliefs in the patients with obsessive compulsive disorder." European Psychiatry 26, S2 (2011): 979. http://dx.doi.org/10.1016/s0924-9338(11)72684-0.

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IntroductionCognitive models hypothesize that certain dysfunctional beliefs leading to misinterpretation of the significance of intrusions are important in the etiology and maintenance of obsessive-compulsive disorder (OCD). There is no consensus about which characteristics of OCD patients more likely to be associated with better treatment response.ObjectivesWe aimed to investigate whether obsessive beliefs change over time in the OCD patients receiving Serotonin Reuptake Inhibitors. We also investigated the effect of change in obsessive beliefs on psychopharmacological treatment response.Meth

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Alsudairy, Najlaa Mohammad, Sultan Abdulaziz Alzhrani, Tahani Mohammed Safer Manea, et al. "Obsessive-Compulsive Disorder in Primary Care: Overview on Diagnosis and Management." Journal of Advanced Zoology 44, S-5 (2023): 1199–208. http://dx.doi.org/10.17762/jaz.v44is-5.1161.

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Background: Obsessive-Compulsive Disorder (OCD) is a debilitating condition marked by the presence of intrusive obsessions and repetitive compulsions. The primary care setting often serves as the first line of contact for individuals grappling with mental health issues, making it a crucial frontier in the early detection and management of OCD. Therefore, the accurate diagnosis of OCD in such settings is essential for effective management. Objective: This review article aims to provide a comprehensive overview of the diagnostic process for OCD, emphasizing the clinical presentation, differentia

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Drazilova, Sylvia, Tomas Koky, Marian Macej, et al. "Pruritus, Fatigue, Osteoporosis and Dyslipoproteinemia in Pbc Patients: A Clinician’s Perspective." Gastroenterology Insights 15, no. 2 (2024): 419–32. http://dx.doi.org/10.3390/gastroent15020030.

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In this review article, we summarize the most common clinical manifestations of Primary biliary cholangitis (PBC): pruritus, fatigue, osteoporosis, and dyslipoproteinemia and discuss their impact of the patients’ quality of life. More than half of PBC patients suffer from pruritus or fatigue at the time of diagnosis. We discuss the pathophysiological aspects of the PBC clinical manifestations and treatment options. The pathophysiology of pruritus and fatigue is not adequately elucidated, but IL-31 is associated with the severity of pruritus and could be used to objectify the subjective reporti

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Floreani, Annarosa, Daniela Gabbia, and Sara De Martin. "Obeticholic Acid for Primary Biliary Cholangitis." Biomedicines 10, no. 10 (2022): 2464. http://dx.doi.org/10.3390/biomedicines10102464.

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Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease that may progress to fibrosis and/or cirrhosis. Treatment options are currently limited. The first-line therapy for this disease is the drug ursodeoxycholic acid (UDCA), which has been proven to normalize serum markers of liver dysfunction, halt histologic disease progression, and lead to a prolongation of transplant-free survival. However, 30–40% of patients unfortunately do not respond to this first-line therapy. Obeticholic acid (OCA) is the only registered agent for second-line treatment in UDCA-non responders

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Babizhayev, Mark A. "Designation of imidazole-containing dipeptides as pharmacological chaperones." Human & Experimental Toxicology 30, no. 7 (2010): 736–61. http://dx.doi.org/10.1177/0960327110377526.

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We review the dichotomous regulatory roles of natural imidazole-containing peptidomimetics (N-acetylcarnosine [NAC], carcinine, non-hydrolized carnosine) in maintaining skin homeostasis that determines whether keratinocytes survive or undergo apoptosis in response to various insults and in the development of skin diseases. General strategies addressing common ground techniques to improve absorption of usually active chaperone proteins or their dipeptide inducer (usually poorly absorbed) compounds include encapsulation into hydrophobic carriers, combination with penetration enhancers, active el

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Floreani, Annarosa, Daniela Gabbia, and Sara De Martin. "Update on the Pharmacological Treatment of Primary Biliary Cholangitis." Biomedicines 10, no. 8 (2022): 2033. http://dx.doi.org/10.3390/biomedicines10082033.

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Ursodeoxycholic acid (UDCA) is the first-line therapy used for the treatment of PBC. In recent years, new pharmacological agents have been proposed for PBC therapy to cure UDCA-non-responders. Obeticholic acid (OCA) is registered in many countries for PBC, and fibrates also seem to be effective in ameliorating biochemistry alteration and symptoms typical of PBC. Moreover, a variety of new agents, acting with different mechanisms of action, are under clinical evaluation for PBC treatment, including PPAR agonists, anti-NOX agents, immunomodulators, and mesenchymal stem cell transplantation. Sinc

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Aranđelović, Branimirka, Svetlana Simić, Slobodanka Bogdanović-Vasić, Milena Mikić, Jovana Uzelac, and Sandra Glamočak. "Palliative care of patients with Parkinson's disease." PONS - medicinski casopis 20, no. 2 (2023): 79–86. http://dx.doi.org/10.5937/pomc20-47261.

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Parkinson's disease is a progressive neurodegenerative disease that most often affects elderly people. The disease is characterized by a wide range of symptoms, motor (tremor, bradykinesia, postural instability and rigidity) and non-motor (neurological and psychiatric disorders, sleep problems, disorders of the autonomic nervous system, etc.), which as the disease progresses lead to significant disability, dependence in performing daily activities activities and impaired quality of life. Given that there is no therapy that could cure, slow down or stop the further development of the disease, i

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Gedawy, Ahmed, Hani Al-Salami, and Crispin R. Dass. "Simultaneous HPLC of Metformin, Glipizide and Gliclazide, and Metformin Uptake and Protection of HEI-OC1 from Hyperglycaemia." Applied Sciences 14, no. 22 (2024): 10469. http://dx.doi.org/10.3390/app142210469.

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The antidiabetic drugs metformin, glipizide and gliclazide have been used for many years to control blood glucose levels. In recent years, they have gained importance in non-diabetic pharmacological purposes including cancer and hearing loss treatment. Co-administration of these therapeutics represents a challenge to some clinicians seeking an efficient, sensitive and rapid analytical method to use in the pharmacokinetic studies and the therapeutic monitoring of these agents. This research outlines the development and validation of a new precise, robust, sensitive, selective and rapid ion-pair

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Stefanović, Katarina, Gordana Mihajlović, and Nebojša Despotović. "Sarcopenia: From clinical aspects to therapeutic possibilities." Srpski medicinski casopis Lekarske komore 3, no. 4 (2022): 436–45. http://dx.doi.org/10.5937/smclk3-41007.

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In recent years, with the increase in life expectancy and the increasing number of elderly people, sarcopenia has been recognized as a separate entity and a new field in geriatric medicine. The European Working Group on Sarcopenia in Older People defined sarcopenia as a syndrome characterized by progressive and generalized loss of skeletal muscle mass, strength and consequently muscle function, which carries with it an increased risk of falls, disability, loss of work ability and premature death. Sarcopenia in the elderly is being given major research focus in many countries, due to its great

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Abith, Baburaj, and R. Shabaraya A. "Tics and Tourette Syndrome - A Complete Review." International Journal of Research and Review 7, no. 6 (2020): 4–8. https://doi.org/10.5281/zenodo.3952057.

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Tourette's syndrome is a trivial neurodegenerative condition characterized by repetitive agitation, tics, and motor and phonic constituents. Tourette syndrome, along with amplified striatal dysfunction, has been conceptualized as a disorder which mainly affects basal ganglia. Some forms of co-morbidity follow TS such as Attention Deficit Hyperactivity Disorder (ADHD), Obsessive Compulsive Behavior/Disorder (OCB/D) and Autism Spectrum Disease (ASD); also mental disorder coexists, such as depression, anxiety, Oppositional Defiant Disorder (ODD), CD and Personality Disorder (PD). Individuals

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Ostroumova, O. D., S. S. Telkova, A. V. Dubinina, et al. "Treatment approaches of hypertriglyceridemia in patients with dyslipidemia and obesity." RMJ, no. 5 (2025): 29–35. https://doi.org/10.32364/2225-2282-2025-5-6.

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The high prevalence of obesity and its associated cardiovascular diseases ( CVD) constitutes a significant medical and social concern. Dyslipidemia is one of the principal risk factors in this patient cohort. Notably, beyond elevated low-density lipoprotein cholesterol (LDL-C) — the primary atherogenic factor — dyslipidemia in obese patients is typically characterized by increased serum triglyceride (TG) levels and reduced high-density lipoprotein cholesterol ( HDL-C) fractions, both of which contribute to the residual risk of CVD even after LDL-C correction. Therefore, the management of dysli

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Ega Yos Sanda, Muhammad Yunus, and Erida Novriani. "Perbandingan Efektivitas Penggunaan Obat Oral Antiabetik Tunggal dan Kombinasi pada Pasien Diabetes Mellitus Tipe 2 di Rumah Sakit Umum Royal Prima Medan." Jurnal Ilmu Kedokteran dan Kesehatan Indonesia 5, no. 2 (2025): 537–53. https://doi.org/10.55606/jikki.v5i2.6857.

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Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels, with a high prevalence in Indonesia. Pharmacological therapy using oral antidiabetic medications (OAD), either singly or in combination, is a primary approach to managing type 2 DM. Evaluating the effectiveness of therapy is essential to ensure the achievement of glycemic targets and to prevent complications. This study aims to compare the effectiveness of using single and combination oral antidiabetic medications in reducing blood glucose levels in patients with type 2 Diabetes Mellitus at Royal

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Udo, Itoro, Carol McDaniel, and Chidi Chima. "Pharmacological management of comorbid obsessive–compulsive disorder and chronic non-affective psychosis." BJPsych Advances, August 17, 2020, 1–13. http://dx.doi.org/10.1192/bja.2020.57.

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SUMMARY The comorbidity of obsessive–compulsive symptoms (OCS) in the context of schizophrenia is often not recognised by clinicians, and patients may not report these symptoms until they become severe. However, there is a reported prevalence of 10–24% for obsessive–compulsive disorder (OCD) in schizophrenia and related disorders. The onset of OCS/OCD has been noted to occur both before and after the diagnosis of schizophrenia or schizoaffective disorder. It has also been known to occur following commencement of treatment with antipsychotic medications, especially clozapine. Current literature

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Kim, Shin Tae, Chun Il Park, Hae Won Kim, Sumoa Jeon, Jee In Kang, and Se Joo Kim. "Dysfunctional Metacognitive Beliefs in Patients With Obsessive–Compulsive Disorder and Pattern of Their Changes Following a 3-Month Treatment." Frontiers in Psychiatry 12 (April 22, 2021). http://dx.doi.org/10.3389/fpsyt.2021.628985.

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Introduction: Metacognitions are considered to be crucial factors for the development and maintenance of pathologic anxiety. The present case–control study aimed to examine how metacognitive beliefs are associated with the diagnostic status and subtypes of obsessive–compulsive disorder (OCD). In addition, we examined the pattern of changes in metacognitive beliefs after a 3-month pharmacological treatment in patients with OCD.Methods: A total of 562 cases with OCD and 236 healthy controls were assessed with the Metacognitions Questionnaire (MCQ) and various measures of OC symptom severity. Mul

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Owe-Larsson, Maja, Katarzyna Kamińska, Barbara Buchalska, Dagmara Mirowska-Guzel, and Agnieszka Cudnoch-Jędrzejewska. "Psilocybin in pharmacotherapy of obsessive-compulsive disorder." Pharmacological Reports, August 1, 2024. http://dx.doi.org/10.1007/s43440-024-00633-1.

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AbstractObsessive-compulsive disorder (OCD) is a chronic mental disease that affects approximately 2% of the population. Obsessions and compulsions are troublesome for patients and may disturb their everyday activities. The pathogenesis of this disease is still not fully elucidated, but dysfunctions of serotonin-, dopamine- and glutamate-mediated neurotransmission together with early maladaptive schemas seem of importance. Pharmacological treatment includes drugs affecting the serotoninergic, dopaminergic, and glutamatergic systems, such as selective serotonin reuptake inhibitors (SSRIs). Prov

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Kerkeni, Ali, and Charles Olivier PONS. "Severe Obsessive‒compulsive Disorder of Transformation in a 13-year-old Adolescent: A Case Report." Current Psychiatry Research and Reviews 21 (January 13, 2025). https://doi.org/10.2174/0126660822351945241215171316.

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Introduction: Obsessive-compulsive Disorder (OCD) with transformation obsession is a rare psychiatric disorder that can pose various diagnostic difficulties and treatment challenges. Scientific research focusing on this disorder in adolescents is scarce. In this work, we present the case of a teenage girl who was treated for severe OCD with transformation obsession. The psychiatric management of this adolescent was performed on an outpatient basis and took place in the juvenile department at Saint Ylie Hospital (France). We hope that our work will add to the existing data on the psychiatric ma

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Howes, Oliver D., Michael E. Thase, and Toby Pillinger. "Treatment resistance in psychiatry: state of the art and new directions." Molecular Psychiatry, July 13, 2021. http://dx.doi.org/10.1038/s41380-021-01200-3.

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AbstractTreatment resistance affects 20–60% of patients with psychiatric disorders; and is associated with increased healthcare burden and costs up to ten-fold higher relative to patients in general. Whilst there has been a recent increase in the proportion of psychiatric research focussing on treatment resistance (R2 = 0.71, p < 0.0001), in absolute terms this is less than 1% of the total output and grossly out of proportion to its prevalence and impact. Here, we provide an overview of treatment resistance, considering its conceptualisation, assessment, epidemiology, impact, and common neu

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Lardner, Anne L. "Neurobiological effects of the green tea constituent theanine and its potential role in the treatment of psychiatric and neurodegenerative disorders." July 23, 2013. https://doi.org/10.1179/1476830513y.0000000079.

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Theanine (n-ethylglutamic acid), a non-proteinaceous amino acid component of green and black teas, has received growing attention in recent years due to its reported effects on the central nervous system. It readily crosses the blood-brain barrier where it exerts a variety of neurophysiological and pharmacological effects. Its most well-documented effect has been its apparent anxiolytic and calming effect due to its up-regulation of inhibitory neurotransmitters and possible modulation of serotonin and dopamine in selected areas. It has also recently been shown to increase levels of brain-deriv

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Santos, Ivan, M. Beatriz P.P. Oliveira, Ana Casas, Javier Fidalgo, and Hugo Almeida. "Understanding the Potential of CBD for Health Benefits: an Overview." Current Drug Discovery Technologies 21 (June 6, 2024). http://dx.doi.org/10.2174/0115701638305553240529103622.

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Abstract: Cannabinoids are compounds with increasing scientific interest, particularly due to their interaction with the endocannabinoid system via CBR1 and CBR2 receptors. They can interfere with appetite, pain, and sleep or develop mood changes in the individual. Cannabidiol (CBD) is a well-known cannabinoid with potential benefits, including reducing epilepsy seizures, alleviating anxiety and obsessive-compulsive disorder (OCD) symptoms, aiding in Tourette Syndrome (a neurodevelopmental disorder), depression, sleep disorders, and promising in the treatment of cancer, pain relief, and heart

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Golebiowska, Maria, Beata Golebiowska, Yi Shiuan Lin, and Malgorzata Wieleba. "Recent reports on dissociative identity disorder." September 3, 2017. https://doi.org/10.5281/zenodo.883822.

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<strong>Golebiowska Maria, Golebiowska Beata, Lin Yi Shiuan, Wieleba Malgorzata</strong><strong>. </strong><strong>Recent reports on dissociative identity disorder</strong><strong>.</strong> <strong>Journal of Education, Health and Sport. 2017;7(9):68-76. eISSN 2391-8306. DOI </strong><strong>http://dx.doi.org/10.5281/zenodo.883822</strong> <strong>http://ojs.ukw.edu.pl/index.php/johs/article/view/4756</strong> <strong>The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017).</strong> <strong>1223 Journal of Education, Health

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Aishwarya, T. S., Nadella Mounika, Gayatri Vishwakarma, and Ramu Adela. "Effect of Obeticholic acid in Non-alcoholic fatty liver disease (NAFLD) and Non-alcoholic steatohepatitis (NASH) patients: A Systematic review and Meta-analysis." RPS Pharmacy and Pharmacology Reports, August 12, 2022. http://dx.doi.org/10.1093/rpsppr/rqac001.

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Abstract Objectives Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are the major public health issues. Though the prevalence of the disease is high, there is no approved pharmacological treatment. Obeticholic acid (OCA) has not been well described in terms of its efficacy and safety in NAFLD/NASH patients. Hence, we investigated the efficacy and safety of OCA in NAFLD/NASH patients. Methods PubMed, Cochrane CENTRAL, and Google Scholar were searched from 2001 to date for identifying randomized controlled trials which examined the OCA effect on liver enzymes,

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Tran, Chanh-Phong, John J. Kim, Jordan J. Feld, and William WL Wong. "Cost-effectiveness of obeticholic acid for the treatment of non-alcoholic steatohepatitis: an early economic evaluation." Canadian Liver Journal, August 20, 2021, e20210011. http://dx.doi.org/10.3138/canlivj-2021-0011.

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Background: Currently, there are no pharmacological options available for the treatment of non-alcoholic steatohepatitis (NASH). In the 18-month interim analysis of an ongoing randomized, placebo-controlled phase 3 trial (REGENERATE), early results demonstrated that obeticholic acid (OCA) 25 mg significantly improved fibrosis with no worsening of NASH among patients with NASH and fibrosis compared to placebo (PBO). This study aimed to assess the potential cost-effectiveness of OCA compared to PBO in NASH patients. Methods: A state-transition model was developed to perform a cost-utility analys

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Sonar, Samiksha J., Vishal Mishra, Anuradha M. Gandhi, Prakruti P. Patel, and Chetna K. Desai. "Evaluation of Oral Antidiabetes Drugs in Patients of Uncontrolled Type 2 Diabetes Mellitus: A Cohort Study." JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, April 1, 2025. https://doi.org/10.7860/jcdr/2025/74419.20834.

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Introduction: The prevalence of uncontrolled Type 2 Diabetes Mellitus (T2DM) is higher due to non compliance to non pharmacological measures or pharmacotherapy, or due to disease progression, despite the availability of various oral antidiabetic drugs. Aim: To evaluate Oral Antidiabetic Drugs (OADs) in terms of treatment outcome as well as adherence. Materials and Methods: This was a single-centre cohort study, patients of uncontrolled T2DM on OAD(s) were enrolled for 12 months and followed-up monthly for six months. Details of blood sugar levels and antidiabetic treatment were recorded at eac

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Nielsen, Malte Hasle, Jacob Nøhr-Meldgaard, Mathias B. Møllerhøj, et al. "Characterization of six clinical drugs and dietary intervention in the non-obese CDAA-HFD mouse model of MASH and progressive fibrosis." American Journal of Physiology-Gastrointestinal and Liver Physiology, October 15, 2024. http://dx.doi.org/10.1152/ajpgi.00110.2024.

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The choline-deficient L-amino acid defined-high fat diet (CDAA-HFD) mouse model is widely used in preclinical metabolic dysfunction-associated steatohepatitis (MASH) research. To validate the CDAA-HFD mouse, we evaluated disease progression and responsiveness to dietary and pharmacological interventions with semaglutide, lanifibranor, elafibranor, obeticholic acid (OCA), firsocostat and resmetirom.Disease phenotyping was performed in C57BL/6J mice fed CDAA-HFD for 3-20 weeks and ranked using the MASLD Human Proximity Score (MHPS). Semaglutide, lanifibranor, elafibranor, OCA, firsocostat or res

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Panyod, Suraphan, Wei-Kai Wu, Meng-Yun Hu, et al. "Healthy diet intervention reverses the progression of NASH through gut microbiota modulation." Microbiology Spectrum, November 29, 2023. http://dx.doi.org/10.1128/spectrum.01868-23.

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ABSTRACT Diet and gut microbiota impact the progression of non-alcoholic steatohepatitis (NASH). An unhealthy diet, rich in fat and sugar, promotes gut microbiota dysbiosis, leading to the translocation of lipopolysaccharides (LPS) and other harmful pathogen-associated molecular patterns to the liver, triggering hepatic inflammation and aggravating NASH. Currently, there are no approved pharmacological treatments for NASH, although novel drugs, such as obeticholic acid (OCA), have demonstrated beneficial effects. Healthy dietary modifications have been proposed to prevent and treat NASH. Howev

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Li, Hongshan, Yingfei Xi, Hongliang Liu, and Xin Xin. "Gypenosides ameliorate high-fat diet-induced non-alcoholic steatohepatitis via farnesoid X receptor activation." Frontiers in Nutrition 9 (August 24, 2022). http://dx.doi.org/10.3389/fnut.2022.914079.

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BackgroundGypenosides (Gyps), the major botanical component of Gynostemma pentaphyllum, was found to up-regulate the farnesoid X receptor (FXR) in a mouse model of non-alcoholic steatohepatitis (NASH). However, the exact role of FXR and underlying mechanisms in Gyps-mediated effects on NASH remain to be elucidated.PurposeThis study investigated whether Gyps attenuates NASH through directly activating FXR in high-fat diet (HFD)-induced NASH, and delineated the molecular pathways involved.Study designA mouse model of HFD-induced NSAH was used to examine effects of Gyps on NASH with obeticholic a

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