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Journal articles on the topic 'Non-Protein Sulfhydryl Groups'

Author: Grafiati

Published: 4 June 2021

Last updated: 14 February 2022

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1

Stuiver, C. Elisabeth E., Luit J. Kok, and Pieter J. C. Kuiper. "Freezing injury in spinach leaf tissue: Effects on water-soluble proteins, protein-sulfhydryl and water-soluble non-protein-sulfhydryl groups." Physiologia Plantarum 74, no. 1 (1988): 72–76. http://dx.doi.org/10.1111/j.1399-3054.1988.tb04943.x.

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Włodek, Przemysław, Maria Sokołowska, Olgierd Smoleński, and Lidia Włodek. "The gamma-glutamyltransferase activity and non-protein sulfhydryl compounds levels in rat kidney of different age groups." Acta Biochimica Polonica 49, no. 2 (2002): 501–7. http://dx.doi.org/10.18388/abp.2002_3809.

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The present work was aimed to obtain information about age-dependent changes of gamma-glutamyltransferase (GGT) activity and the levels of non-protein sulfhydryl compounds (NPSH) in rat kidneys. In addition, protein-bound cysteine (PB-Cys), sulfane sulfur compounds and reactive oxygen species (ROS) were estimated. The results indicate that the activity of GGT and NPSH levels in the kidneys are reduced with age. At the same time, a significant increase in the level of protein-bound cysteine was observed. Simultaneously, the content of sulfane sulfur compounds was increased in the group of the o

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Liszewska, F., A. Blaszczyk, and A. Sirko. "Modification of non-protein thiols contents in transgenic tobacco plants producing bacterial enzymes of cysteine biosynthesis pathway." Acta Biochimica Polonica 48, no. 3 (2001): 647–56. http://dx.doi.org/10.18388/abp.2001_3899.

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Conditions of achieving the maximal accumulation of sulfhydryl metabolites in the leaves of tobacco were explored. Simultaneous production of bacterial O-acetylserine (thiol)-lyase and serine acetyltransferase resulted in the increased thiols contents as compared to single transformants and controls. However, leaf discs feeding experiments differently affected thiols concentration in different plant groups and suggested that the most promising strategy to obtain plants with a high level of non-protein thiol-containing compounds might be sulfate feeding to plants overproducing serine acetyltran

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Korotkyi, O., L. Kot, K. Dvorshchenko, and L. Ostapchenko. "Oxidative modification of proteins in rat serum under experimental osteoarthritis and joint administration of a chondroprotector and multiprobiotic." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 81, no. 2 (2020): 64–68. http://dx.doi.org/10.17721/1728_2748.2020.81.64-68.

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One of the actual problems of modern medicine is joint disease. Among them, osteoarthritis occupies an important place. The formation of osteoarthritis is accompanied by the development of inflammation, which leads to damage to all structures of the joint. An important role in inflammatory processes is played by the intensification of free radical processes. As the disease develops, the joints lose their mobility, which leads to a decrease in the quality of life of patients and the development of disability. In this regard, it is important to search for drugs that have regenerative, anti-infla

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Bilska-Wilkosz, Anna, Magdalena Ochenduszka, Małgorzata Iciek, et al. "Effects of acetylsalicylic acid on the levels of sulfane sulfur and non-protein sulfhydryl groups in mouse tissues." Pharmacological Reports 65, no. 1 (2013): 173–78. http://dx.doi.org/10.1016/s1734-1140(13)70975-7.

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Boeing, Thaise, Luisa Natália Bolda Mariano, Ana Caroline dos Santos, et al. "Gastroprotective effect of the alkaloid boldine: Involvement of non-protein sulfhydryl groups, prostanoids and reduction on oxidative stress." Chemico-Biological Interactions 327 (August 2020): 109166. http://dx.doi.org/10.1016/j.cbi.2020.109166.

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Mota, José Maurício S. C., Pedro M. G. Soares, Álvaro A. J. Menezes, et al. "Amifostine (Wr-2721) Prevents Indomethacin-Induced Gastric Damage in Rats: Role of Non-Protein Sulfhydryl Groups and Leukocyte Adherence." Digestive Diseases and Sciences 52, no. 1 (2006): 119–25. http://dx.doi.org/10.1007/s10620-006-9496-3.

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Hedin, Eva MK, Shamkant A. Patkar, Jesper Vind, Allan Svendsen, Karl Hult, and Per Berglund. "Selective reduction and chemical modification of oxidized lipase cysteine mutants." Canadian Journal of Chemistry 80, no. 6 (2002): 529–39. http://dx.doi.org/10.1139/v02-046.

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Thirteen single-cysteine mutants of the 33 kDa fungal triacylglycerol lipase Thermomyces (formerly Humicola) lanuginosa lipase (TLL, EC 3.1.1.3) were produced and characterized for the purpose of site-directed chemical modification with spectroscopic reporter groups. All cysteine mutants were found to be predominantly blocked by oxidation to disulfides with endogenous cysteine during production. The fraction of lipase molecules with free sulfhydryl groups was analyzed by labeling with N-biotinylaminoethyl methanethiosulfonate, followed by a novel dot-blot method based on biotin-streptavidin in

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La Casa, C., M. J. Martín Calero, C. Alarcón de la Lastra, et al. "Role of Mucus Secretion and Sulfhydryl Groups in Gastroprotection Mediated by a Flavonoid Fraction of Bidens aurea." Zeitschrift für Naturforschung C 50, no. 11-12 (1995): 854–61. http://dx.doi.org/10.1515/znc-1995-11-1218.

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Abstract The aerial parts of Bidens aurea (Aiton) Sherff have been used in folk medicine as an antiulcer agent. The efficacy of an ether extract to prevent gastric mucosal damage produced by several necrotic agents was studied in rats. The best efficiency was against lesions induced by 30% NaCl with a significant decrease of damage at all doses tested (250, 125 and 62.5 mg kg-1). In contrast, only the highest dose (250 mg kg-1) was effective on gastric erosions induced by 0.6 ɴ HCl. This effect could not be related with the mucus gel production only since the groups treated with of absolute et

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Gomes, Antoniella Souza, Henrique Paula Lemos, Jand Venes Rolim Medeiros, Fernando Queiroz Cunha, and Marcellus Henrique Loiola Ponte Souza. "Lipopolysaccharide from Escherichia coli prevents indomethacin-induced gastric damage in rats: role of non-protein sulfhydryl groups and leukocyte adherence." Inflammation Research 58, no. 10 (2009): 717–23. http://dx.doi.org/10.1007/s00011-009-0040-8.

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Blokhina, O., O. Korotkiy, L. Kot, D. Negray, and K. Dvorshchenko. "Oxidative modification of proteins in serum of rats under conditions of carrageenan-induced inflammation of a back limb and prolonged prophylactic administration of chondroitin sulfate." Bulletin of Taras Shevchenko National University of Kyiv. Series: Biology 76, no. 2 (2018): 62–65. http://dx.doi.org/10.17721/1728_2748.2018.76.62-65.

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The aim of the work was to investigate the preventive effect of Chondroitin Sulfate on the content of products of oxidative modification of proteins and the level of sulfhydryl groups in blood serum of rats at local inflammation of the hind limb. The studies were conducted on white non-linear, sexually mature male rats weighing 180–240 g, in compliance with the general ethical principles of experiments on animals. All animals were divided into four experimental groups. The first group – control: animals sub-planar injected 0,1 ml of 0,9 % NaCl solution into the posterior right limb. The second

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Skrzydlewska, E., and R. Farbiszewski. "Liver and serum antioxidant status after methanol intoxication in rats." Acta Biochimica Polonica 44, no. 1 (1997): 139–45. http://dx.doi.org/10.18388/abp.1997_4451.

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Activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-R) and concentration of ascorbate, alpha-tocopherol, non-protein and protein-bound sulfhydryl compounds and thiobarbituric acid-reactive substances (TBA-rs) were measured in liver and serum of rats 6, 12 and 24 h and 2, 5 and 7 days after intoxication with 1.5 g or 3.0 g methanol/kg b.w. Liver GSH-Px and GSSG-R activities and SH-groups and ascorbate content were significantly diminished at 6 and 24 h, while TBA-rs were increased. Serum SOD, GSH-Px and GSSG-R activities and SH-gro

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Paier, B., K. Hagmüller, M. I. Noli, M. Gonzalez Pondal, C. Stiegler, and A. A. Zaninovich. "Changes induced by cadmium administration on thyroxine deiodination and sulfhydryl groups in rat liver." Journal of Endocrinology 138, no. 2 (1993): 219–24. http://dx.doi.org/10.1677/joe.0.1380219.

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ABSTRACT The effects of cadmium on 5′-deiodination of thyroxine (T4) by rat liver and on the hepatic concentration of non-protein sulfhydryl groups (NPSH) were studied in Wistar rats of 200–250 g body weight. A group of ten rats was injected with cadmium chloride (300 μg/100 g body weight i.p.) daily for 4 days. Another group of six rats received, in addition, dithiothreitol (DTT; 1 mg/100 g body weight i.p.) daily for the same period. A group of eight normal untreated rats served as control. T4 deiodination was also determined in aliquots of liver from untreated rats, with cadmium (2 or 5 mmo

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Szczubiał, M., M. Kankofer, R. Dąbrowski, M. Bochniarz, and R. Urban-Chmiel. "Assessment of lipid and protein peroxidation markers in non-pregnant and pregnant female dogs." Polish Journal of Veterinary Sciences 18, no. 1 (2015): 171–79. http://dx.doi.org/10.1515/pjvs-2015-0022.

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AbstractThe aim of the study was to investigate oxidative stress during normal pregnancy in female dogs based on an evaluation of plasma markers for lipid and protein peroxidation. Twenty clinically healthy female dogs (10 non-pregnant and 10 pregnant) were used in the study. Blood samples from the pregnant animals were collected at 19-21, 38-40, and 56-58 days of pregnancy. Blood samples from non-pregnant female dogs were obtained between 20 and 35 days after ineffective breeding. As indicators of oxidative stress, we measured the following using spectrophotometric and spectrofluorimetric met

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Vovk, A., O. Korotkyi, L. Kot, and K. Dvorshchenko. "Oxidative modification of proteins in rat serum under experimental osteoarthrosis and long-term administration of a multiprobiotic." Bulletin of Taras Shevchenko National University of Kyiv. Series: Problems of Physiological Functions Regulation 26, no. 1 (2019): 50–54. http://dx.doi.org/10.17721/1728_2624.2019.26.50-54.

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The aim of the study was to investigate the effect of multiprobiotics on the content of products of oxidative modification of proteins and the level of sulfhydryl groups in blood serum of rats during monoiodoacetate-induced osteoarthritis. The study was carried out on white non-linear, sexually mature male rats (weight 180-240 g), according to general ethical principles of experiments on animals. All animals were divided into four experimental groups. The first group - Control: animals got injection into knee ligament 0.05 ml of 0.9% NaCl solution on the first day of the experiment and then go

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Macedo, Gabriel de Souza, Juliana Giacomazzi, Cristina Netto, Leonardo Motta, Fábio Klamt, and Patricia Ashton-Prolla. "Antioxidants and oxidative stress in patients with Li-Fraumeni-like syndrome and TP53 p.R337H mutation carriers." Journal of Clinical Oncology 30, no. 15_suppl (2012): e21042-e21042. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e21042.

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e21042 Background: Germline mutations in the TP53 gene are the underlying genetic defect of Li-Fraumeni Syndrome (LFS) and its variant, Li-Fraumeni-like (LFL) Syndrome, autosomal dominant disorders characterized by predisposition to multiple early-onset cancers. More recently, p53 is emerging as an important player in redox metabolism and important enzymes involved in defenses against oxidative stress have shown to be regulated by p53, including glutathione peroxidase 1 (GPX1) and mitochondrial superoxide dismutase 2 (SOD2). The aim of the present study was to investigate the redox profile par

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Wu, X., N. H. Bishopric, D. J. Discher, B. J. Murphy, and K. A. Webster. "Physical and functional sensitivity of zinc finger transcription factors to redox change." Molecular and Cellular Biology 16, no. 3 (1996): 1035–46. http://dx.doi.org/10.1128/mcb.16.3.1035.

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Redox regulation of DNA-binding proteins through the reversible oxidation of key cysteine sulfhydryl groups has been demonstrated to occur in vitro for a range of transcription factors. The direct redox regulation of DNA binding has not been described in vivo, possibly because most protein thiol groups are strongly buffered against oxidation by the highly reduced intracellular environment mediated by glutathione, thioredoxin, and associated pathways. For this reason, only accessible protein thiol groups with high thiol-disulfide oxidation potentials are likely to be responsive to intracellular

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Zych, Maria, Weronika Wojnar, Magdalena Kielanowska, Joanna Folwarczna, and Ilona Kaczmarczyk-Sedlak. "Effect of Berberine on Glycation, Aldose Reductase Activity, and Oxidative Stress in the Lenses of Streptozotocin-Induced Diabetic Rats In Vivo—A Preliminary Study." International Journal of Molecular Sciences 21, no. 12 (2020): 4278. http://dx.doi.org/10.3390/ijms21124278.

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Diabetes mellitus affects the eye lens, leading to cataract formation by glycation, osmotic stress, and oxidative stress. Berberine, an isoquinoline alkaloid, is a natural compound that has been reported to counteract all these pathological processes in various tissues and organs. The goal of this study was to evaluate whether berberine administered at a dose of 50 mg/kg by oral gavage for 28 days to rats with streptozotocin-induced diabetes reveals such effects on the biochemical parameters in the lenses. For this purpose, the following lenticular parameters were studied: concentrations of so

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Ketsa, O. V., N. B. Kutsak, and M. M. Marchenko. "Effect of laser irradiation on xanthine oxidase activity and superoxide radical generation in rat liver cytosol fraction." Animal Biology 22, no. 2 (2020): 54–57. http://dx.doi.org/10.15407/animbiol22.02.054.

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The effect of tumor growth in the body and laser irradiation on the enzymatic activity of xanthine oxidase, in particular its D- and O-forms, and also the rate of generation of the superoxide radical (O2–) and the level of protein sulfhydryl groups in the liver rat cytosolic fraction has been investigated. It has been found that in the cytosolic fraction of rats with transplanted Guerin’s carcinoma decreases the enzymatic activity of the D-form of xanthine oxidase with a simultaneous increase in its O-form during the period of intensive (14 days, which corresponds to the logarithmic phase of o

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Eslami-farsani, M., A. Moslehi, and A. Hatami-shahmir. "Allantoin improves histopathological evaluations in a rat model of gastritis." Physiology International 105, no. 4 (2018): 325–34. http://dx.doi.org/10.1556/2060.105.2018.4.30.

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Purpose Gastritis is found to be one of the most common gastrointestinal diseases worldwide. However, current therapeutic agents cause side effects, interaction, and recurrence. Allantoin has anti-inflammatory and wound healing properties. In this study, the therapeutic effect of allantoin has been assessed on the histopathological indices and gastric mucosal barrier of male rats. Methods Male rats were equally divided into control, ethanol-induced gastritis, and allantoin groups. The therapeutic groups consisted of gastritis plus 12.5 mg/kg allantoin, gastritis plus 25 mg/kg allantoin, and ga

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Dridi, Chaima, Mathieu Millette, Blanca Aguilar, Johanne Manus, Stephane Salmieri, and Monique Lacroix. "Effect of Physical and Enzymatic Pre-Treatment on the Nutritional and Functional Properties of Fermented Beverages Enriched with Cricket Proteins." Foods 10, no. 10 (2021): 2259. http://dx.doi.org/10.3390/foods10102259.

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The aim of this study was to evaluate the effects of γ-irradiation (IR), ultrasound (US), and combined treatments of ultrasound followed by γ-irradiation (US-IR), ultrasound followed by enzymatic hydrolysis with and without centrifugation (US-E and US-EWC, respectively), and ultrasound followed by γ-irradiation and enzymatic hydrolysis (US-IRE), on the digestibility and the nutritional value of fermented beverages containing probiotics. Results showed that US (20 min), IR (3 kGy) and US-IR (tUS = 20 min, dose = 3 kGy) treatments raised protein solubility from 11.5 to 21.5, 24.3 and 29.9%, resp

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Olszowski, S., E. Olszowska, T. Stelmaszyńska, A. Krawczyk, J. Marcinkiewicz, and N. Baczek. "Oxidative modification of ovalbumin." Acta Biochimica Polonica 43, no. 4 (1996): 661–72. http://dx.doi.org/10.18388/abp.1996_4462.

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Stimulated neutrophils (PMNL) are a source of the active oxygen species: O2, H2O2 and HOCl/OCl- which in turn can act on proteins yielding a variety of mixed oxidation products. A system is proposed in which a model protein-ovalbumin (OVA) first undergoes chlorination by HOCl/OCl- and next is oxidised by H2O2. The modification of functional groups (-NH2, -SH, -S-S-, > C = O, Tyr and Trp) in OVA was monitored as well as their accessibility to promote aggregation. Chlorination resulted in additional inter- or intra -S-S- bond formation followed by a decrease in the total sulfhydryl group cont

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Patel, Milap R., and Patel Bg. "ANTI-CATARACT ACTIVITY OF GARCINIA INDICA AGAINST NAPHTHALENE-INDUCED CATARACT IN RATS." Asian Journal of Pharmaceutical and Clinical Research 11, no. 6 (2018): 208. http://dx.doi.org/10.22159/ajpcr.2018.v11i6.24913.

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Objective: The objective of this study is to investigate the anti-cataract activity of the aqueous extract of Garcinia indica (AGI) fruit rinds on naphthalene-induced cataract using rats.Methods: Anti-cataract activity of AGI was evaluated using naphthalene model. Rats were divided into five groups (n=6 in each). Naphthalene solution was prepared by dissolving naphthalene in warm corn oil and administered at the dose of 0.5 g/kg/day p.o. for first 3 days and 1 g/kg/day p.o. thereafter for the induction of cataract. Group I normal control received corn oil 5 ml/kg/day. Group II cataract control

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Doğan, Muhittin, Serap Sahin Yigit, Gülsüm Dogancay, Didem Koçum, and Mustafa Sevindik. "Effects of single and binary applications of bisphenol A and NaCl on Ceratopyllum demersum." Turkish Journal of Agriculture - Food Science and Technology 8, no. 10 (2020): 2164–69. http://dx.doi.org/10.24925/turjaf.v8i10.2164-2169.3631.

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Determining the physiological effects of single and binary applications of BPA and NaCl on the Ceratophyllum demersum L., which is a rootless submerged aquatic macrophyte, is the aim of the present study. For this purpose, the macrophyte was collected from a local pond that was not exposed to any pollution. Macrophytes were acclimatized in 10% nutrient solution for 14 days, than they were treated with 17.2 mg/L BPA; 10 and 100 mM NaCl; 17.2 mg/L BPA plus 10 mM NaCl and 17.2 mg/L BPA plus 100 mM NaCl. The macrophyte without added BPA or/and NaCl served as control (without treatment). Increasing

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Liu, Jerry X., Tomoyuki Endo, Thomas J. Kipps, Carson A. Dennis та Lu Desheng. "Ethacrynic Acid Can Inhibit Wnt/β-Catenin Signaling and Induce Apoptosis in Chronic Lymphocytic Leukemia Cells." Blood 108, № 11 (2006): 2099. http://dx.doi.org/10.1182/blood.v108.11.2099.2099.

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Abstract Chronic lymphocytic leukemia (CLL) is caused by an abnormal balance in signals for survival and cell death. Recently, CLL cells are shown to have an activated Wnt/β-catenin pathway, which may contribute to the apoptosis-resistant state characteristic of this disease. Accordingly, inhibitors of the Wnt/β-catenin pathway may compromise the viability of CLL cells in vitro and in vivo. To identify potential inhibitors of the Wnt/β-catenin pathway, we screened the Gen-Plus drug library using a Wnt/β-catenin TOPflash reporter plasmid in HEK293 cells. Although 99% of the 960 drugs screened w

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Dytfeld, Dominik, Magdalena Luczak, Tomasz Szczepaniak, et al. "Comparative Proteomic Profiling of Sera from Patients with Refractory Multiple Myeloma Reveals Pathways and Biomarkers Predicting Response to Bortezomib-Based Therapy." Blood 128, no. 22 (2016): 2092. http://dx.doi.org/10.1182/blood.v128.22.2092.2092.

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Abstract Introduction: Identification of drug-resistance biomarkers in multiple myeloma (MM) is a first step to individualization of treatment. Human serum is easily collected and does not require expensive preparation to analyze, therefore it seems the most suitable material to search for biomarkers. Objective: The goal of this study was to establish serum biomarkers predicting response/resistance to PAD (bortezomib, adriamycin, dexamethasone) chemotherapy in patients with refractory MM. Material and Methods:Comparative proteome analysis was performed on pretreatment serum samples obtained fr

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van Dijk, Peter R., Amaal Eman Abdulle, Marian L. C. Bulthuis, et al. "The Systemic Redox Status Is Maintained in Non-Smoking Type 2 Diabetic Subjects Without Cardiovascular Disease: Association with Elevated Triglycerides and Large VLDL." Journal of Clinical Medicine 9, no. 1 (2019): 49. http://dx.doi.org/10.3390/jcm9010049.

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Decreased circulating levels of free thiols (R-SH, sulfhydryl groups) reflect enhanced oxidative stress, which plays an important role in the pathogenesis of cardiometabolic diseases. Since hyperglycemia causes oxidative stress, we questioned whether plasma free thiols are altered in patients with type 2 diabetes mellitus (T2DM) without cardiovascular disease or renal function impairment. We also determined their relationship with elevated triglycerides and very low density lipoproteins (VLDL), a central feature of diabetic dyslipidemia. Fasting plasma free thiols (colorimetric method), lipopr

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Muthu, Muthumani, Sumedha Naroem Chanu, Shagirtha Kalist, and Milton Prabu. "Defensive role of silibinin against arsenic induced oxidative stress mediated dyslipidemia and neurotoxicity in rats." International Journal of Pharmacology and Toxicology 4, no. 1 (2016): 78. http://dx.doi.org/10.14419/ijpt.v4i1.5803.

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Arsenic (As) is an environmental toxic metalloid that is present in everywhere such as air, water and soil. Generally, inorganic arsenic has a tendency to be more toxic than organic arsenic. The present study was designed to determine whether oral administration of silibinin (SB), which has been shown to have substantial antioxidant properties, when pre-administered (75 mg/kg body weight) once daily for 4 weeks along with arsenic (5 mg/kg) would prevent arsenic-induced changes in antioxidant defense system, superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX),glutathione-S-

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Kacarevic, Dragana, Natasa Bogavac-Stanojevic, Vesna Spasojevic-Kalimanovska, et al. "Factors associated with oxidative stress status in pediatric patients with type 1 diabetes mellitus." Journal of Pediatric Endocrinology and Metabolism 33, no. 5 (2020): 591–98. http://dx.doi.org/10.1515/jpem-2019-0555.

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AbstractBackgroundOxidative stress is implicated in both, the onset and the progression of type 1 diabetes mellitus (T1DM). There is accumulated evidence of increased biomarkers of oxidative stress in newly diagnosed, T1DM patients without complications, and in those with advanced disease. In this cross-sectional study, we investigated factors affecting oxidative stress status in pediatric patients with T1DM.MethodsAdvanced oxidation protein products (AOPP), prooxidant-antioxidant balance (PAB), total sulfhydryl (SH) groups, and superoxide dismutase (SOD) activity were determined in 170 childr

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OA, Al-Shabanah, El-Hadiyah TM, and Al-Majed AA. "Effect of prolonged vigabatrin treatment on hematological and biochemical parameters in plasma, liver and kidney of Swiss albino mice." Scientia Pharmaceutica 70, no. 2 (2002): 135–45. http://dx.doi.org/10.3797/scipharm.aut-02-16.

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We have evaluated vigabatrin (γ-vinyl γ-aminobutyric acid), an irreversible inhibitor of γ-aminobutyric acid (GABA)-transaminase responsible for GABA degradation, for its effects on food consumption, body weight changes, fluid intake, changes in hematological and biochemical parameters in plasma liver and kidney of Swiss albino mice. Mice received vigabatrin 0.26% wlv chronically in drinking water for 7, 14 and 21 days. Changes in all the parameters were recorded aRer 7, 14 and 21 days respectively in different groups. Food consumption was comparable to the control group with minor fluctuation

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Grujic, Zorica, Ilija Grujic, Mirjana Bogavac, Aleksandra Nikolic, Radoslav Mitic, and Zoran Stajic. "Disturbance of oxidative balance in the first trimester of spontaneous abortions." Vojnosanitetski pregled 73, no. 11 (2016): 1038–43. http://dx.doi.org/10.2298/vsp150321123g.

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Background/Aim. Pregnancy is defined as a condition of increased oxidative stress. The aim of this research was to determine the intensity of pro-oxidative processes and the content of GSH, as well as antioxidative enzymes: superoxide dismutase (SOD), catalase (CAT), gluthatione peroxidase (GSH-Px), and the total antioxidative status (TAS) in patients with spontaneous abortions. Methods. A total of 120 patients were involved in the research (70 spontaneous abortions and 50 healthy pregnancies). The patients were divided into groups: 35 patients with incomplete and complete spontaneous abortion

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Justino, Priscilla F. C., Luis F. M. Melo, Andre F. Nogueira, et al. "Treatment withSaccharomyces boulardiireduces the inflammation and dysfunction of the gastrointestinal tract in 5-fluorouracil-induced intestinal mucositis in mice." British Journal of Nutrition 111, no. 9 (2014): 1611–21. http://dx.doi.org/10.1017/s0007114513004248.

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Intestinal mucositis is an important toxic side effect of 5-fluorouracil (5-FU) treatment.Saccharomyces boulardiiis known to protect from intestinal injury via an effect on the gastrointestinal microbiota. The objective of the present study was to evaluate the effect ofS. boulardiion intestinal mucositis induced by 5-FU in a murine model. Mice were divided into saline, saline (control)+5-FU or 5-FU+S. boulardii(16 × 109colony-forming units/kg) treatment groups, and the jejunum and ileum were removed after killing of mice for the evaluation of histopathology, myeloperoxidase (MPO) activity, and

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Turnheim, K. "Intrinsic regulation of apical sodium entry in epithelia." Physiological Reviews 71, no. 2 (1991): 429–45. http://dx.doi.org/10.1152/physrev.1991.71.2.429.

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In the past 30 years the basic features of Na+ absorption by epithelia have been unraveled and generally accepted cell models have been established. However, these cell models of transepithelial Na+ transport represent, for the most part, a static view of cell function, i.e., all transport parameters are assumed to be in a steady state. Today the focus is on the dynamic properties of epithelia, the non-steady-state condition, and the adaptation to environmental or transport changes. This review deals with mechanisms intrinsic to the epithelium that regulate apical membrane Na+ permeability in

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Panes, Olga, Paula Ibarra, Valeria Matus, Claudia G. Sáez, Jaime Pereira та Diego Mezzano. "Platelet Tissue Factor: Expression of Pro-Coagulant Activity depends on Gpibα Activation and Signaling through Lyn-Mediated Phosphorylation. A Platelet-Based Model of Hemostasis". Blood 112, № 11 (2008): 113. http://dx.doi.org/10.1182/blood.v112.11.113.113.

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Abstract Human platelets synthesize and store functionally silent tissue factor (TF) which has procoagulant activity (PCA) after platelet activation. We now explored the location of inactive and active forms of TF and mechanisms of activation. We reported that resting, non-permeabilized human platelets express scant surface TF, which was strikingly enhanced and co-localized with GPIbα after stimulation (Blood2007;109:5242). The externalization of TF was confirmed by immunoprecipitation (Ip) from biotinylated membranes before and after platelet activation. Moreover, TF and GPIbα co-precipitated

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Pendurthi, Usha, Samit Ghosh, Samir Mandal, and L. Vijaya Mohan Rao. "Tissue Factor Activation: Is Disulfide Switching a General Regulatory Mechanism?." Blood 108, no. 11 (2006): 1747. http://dx.doi.org/10.1182/blood.v108.11.1747.1747.

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Abstract Tissue factor (TF) is the cellular receptor for plasma clotting factor VIIa, and the formation of TF-VIIa complexes on cell surfaces trigger the coagulation cascade and cell signaling. It is a well-known fact that only a small fraction of TF at the cell surface is coagulantly active whereas a majority of TF on the cell surface is non-functional (cryptic). However, it is unclear, at present, how the coagulant active TF differs from the cryptic form, and mechanisms involved in TF activation. Recent studies show that a thiol oxidizing agent, HgCl2, increases TF coagulant activity on the

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Al-Ghamdi, Amal Ahmed Mohammed, Manal El-Zohri, and Abdelaaty A. Shahat. "Hepatoprotective, nephroprotective, anti-amylase, and antiglucosidase effects of Ziziphus spina-christi (L.) against carbon tetrachloride-induced toxicity in rats." Tropical Journal of Pharmaceutical Research 18, no. 4 (2021): 781–90. http://dx.doi.org/10.4314/tjpr.v18i4.15.

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Purpose: To explore the hepatoprotective, nephroprotective, anti-amylase, and anti-glucosidase effects of the medicinal plant Ziziphus spina-christi (L.). Methods: Ziziphus spina-christi (L.) methanol extract (ZS-1) and its ethyl-acetate (ZS-2), n-butanol (ZS3), and aqueous (ZS-4) fractions were evaluated for their hepatoprotective, anti-amylase, and antiglucosidase activities. Adult male Wister rats were divided into 11 groups (I- XI) with 6 mice per group. Group I was normal control, while the treatment groups were as follows: group II, CCl4; group III, Silymarin + CCl4; group IV, Zizi

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Cola-Miranda, Maira, Victor Barbastefano, Clélia Akiko Hiruma-Lima, Tamara Regina Calvo, Wagner Vilegas, and Alba Regina Monteiro Souza Brito. "Antiulcerogenic activity of Indigofera truxillensis Kunth." Biota Neotropica 6, no. 3 (2006). http://dx.doi.org/10.1590/s1676-06032006000300004.

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The genus Indigofera (Fabaceae) is used in folk medicine to treat gastrointestinal pain. In this study, we investigated the antiulcerogenic properties of Indigofera truxillensis Kunth. Oral administration of MeOH extract did not produce any signals of acute toxicity. The antiulcerogenic activity was assessed in different models of acute gastric ulcers (100% ethanol, piroxicam 30 mg.kg-1, hypothermic restraint stress and pylorus ligature) in mice and rats. The animals were treated with the drugs lanzoprazole (30 mg.kg-1) or cimetidine (100 mg.kg-1) as positive controls depending on the performe

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Zhang, M., E. G. Bromfield, T. Veenendaal, J. Klumperman, J. B. Helms, and B. M. Gadella. "Characterization of different oligomeric forms of CRISP2 in the perinuclear theca versus the fibrous tail structures of boar spermatozoa." Biology of Reproduction, July 26, 2021. http://dx.doi.org/10.1093/biolre/ioab145.

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Abstract Mammalian sperm carry a variety of highly condensed insoluble protein structures such as the perinuclear theca, the fibrous sheath and the outer dense fibers, which are essential to sperm function. We studied the role of cysteine rich secretory protein 2 (CRISP2); a known inducer of non-pathological protein amyloids, in pig sperm with a variety of techniques. CRISP2, which is synthesized during spermatogenesis, was localized by confocal immunofluorescent imaging in the tail and in the post-acrosomal region of the sperm head. High resolution localization by immunogold labeling electron

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Fernandes, Matheus Santos de Sousa, Lucas de Lucena de Simões e. Silva, Márcia Saldanha Kubrusly, et al. "Aerobic Exercise Training Exerts Beneficial Effects Upon Oxidative Metabolism and Non-Enzymatic Antioxidant Defense in the Liver of Leptin Deficiency Mice." Frontiers in Endocrinology 11 (November 27, 2020). http://dx.doi.org/10.3389/fendo.2020.588502.

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Non-alcoholic fatty liver disease (NAFLD) is one of the most common forms of liver disease, which is associated with several etiological factors, including stress and dysfunction in oxidative metabolism. However, studies showed that aerobic exercise training (AET) can combat the oxidative stress (OS) and improves mitochondrial functionality in the NAFLD. To test the hypothesis that AET improves oxidative metabolism and antioxidant defense in the liver of ob/ob mice. Male ob/ob mice with eight weeks old were separated into two groups: the sedentary group (S), n=7, and the trained group (T), n=7

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Kunnath, Sarika, Bindu Jaganath, Satyen Kumar Panda, Amjad K. Balange, and Venkateshwarlu Gudipati. "Effect of high pressure and setting condition on physico-chemical, structural and functional characteristics of transglutaminase mediated fish gels." Food Science and Technology International, December 10, 2020, 108201322097810. http://dx.doi.org/10.1177/1082013220978103.

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Application of High pressure and low temperature setting condition on microbial transglutaminase (MTGase) mediated gelation was studied against conventional cooking in pink perch mince. A high pressure of 250 MPa was given to pink perch mince samples added with and without MTGase enzyme, for a holding time of 12 min and a setting condition of 25 °C for 30 min was given prior and after the treatments. Nine random experiments (T1 to T9) were made against high pressure and cooking and analysed its textural and functional properties. Addition of MTGase and setting conditions had significant effect

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