Academic literature on the topic 'Non-viral gene transfer'

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Journal articles on the topic "Non-viral gene transfer"

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Wolff, Jon. "Non-Viral Gene Transfer." Nature Biotechnology 17, S4 (1999): 9. http://dx.doi.org/10.1038/70119.

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Lechardeur, Delphineq, and Gergely Lukacs. "Intracellular Barriers to Non-Viral Gene Transfer." Current Gene Therapy 2, no. 2 (2002): 183–94. http://dx.doi.org/10.2174/1566523024605609.

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Peeters, L., N. N. Sanders, J. Demeester, and S. C. De Smedt. "Challenges in non-viral ocular gene transfer." Biochemical Society Transactions 35, no. 1 (2007): 47–49. http://dx.doi.org/10.1042/bst0350047.

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Nowadays, there is no effective treatment for many retinal disorders. Knowledge of the genetic basis of many severe ocular diseases may allow for alternative treatments by gene therapy. Non-viral gene complexes, such as lipo- and poly-plexes, can be delivered to the posterior segment, most often the target tissue, by intravitreal or subretinal injection. Since subretinal injections are very invasive, intravitreal injection is a promising alternative route to deliver gene complexes into the eye. However, the drawback of this technique is the relative long distance the complexes have to travel t
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Haupt, Gerald, and Angela Haupt. "963: Non Viral Gene Transfer by Jet Injection." Journal of Urology 171, no. 4S (2004): 255. http://dx.doi.org/10.1016/s0022-5347(18)38200-4.

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Ziady, Assem G., Pamela B. Davis, and Michael W. Konstan. "Non-viral gene transfer therapy for cystic fibrosis." Expert Opinion on Biological Therapy 3, no. 3 (2003): 449–58. http://dx.doi.org/10.1517/14712598.3.3.449.

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George, Andrew J. T. "PEPTIDE-MEDIATED NON-VIRAL GENE TRANSFER FOR TRANSPLANTATION." Transplantation 69, no. 6 (2000): 1031–33. http://dx.doi.org/10.1097/00007890-200003270-00001.

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Abdallah, Bassima, Laurent Sachs, and Barbara A. Demeneix. "Non-viral gene transfer: Applications in developmental biology and gene therapy." Biology of the Cell 85, no. 1 (1995): 1–7. http://dx.doi.org/10.1111/j.1768-322x.1995.tb00937.x.

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Matsuno, Yukihiro, Hisashi Iwata, Yukio Umeda, Hisato Takagi, Yoshio Mori, and Hajime Hirose. "NON-VIRAL GENE GUN-MEDIATED GENE TRANSFER INTO THE BEATING HEART." ASAIO Journal 48, no. 2 (2002): 188. http://dx.doi.org/10.1097/00002480-200203000-00248.

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Elmer, Jacob J., Matthew D. Christensen, and Kaushal Rege. "Applying horizontal gene transfer phenomena to enhance non-viral gene therapy." Journal of Controlled Release 172, no. 1 (2013): 246–57. http://dx.doi.org/10.1016/j.jconrel.2013.08.025.

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NIKOL, S. "Viral or non-viral angiogenesis gene transfer—New answers to old questions." Cardiovascular Research 73, no. 3 (2007): 443–45. http://dx.doi.org/10.1016/j.cardiores.2006.12.005.

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Dissertations / Theses on the topic "Non-viral gene transfer"

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Bremner, K. Helen. "Application of nuclear localization sequences to non-viral gene delivery systems." Thesis, University of Birmingham, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.273725.

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Collins, Louise. "A non-viral vector system for efficient gene transfer via membrane integrins." Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321961.

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Xenariou, Stefania. "Magnetofection and sonoporation to enhance non-viral gene transfer to airway epithelium." Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433595.

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Bowden, Jonathan Kirk. "Development of a viral and a non-viral based gene transfer systems using the yeast Saccharomyces cerevisiae." Thesis, Brunel University, 2016. http://bura.brunel.ac.uk/handle/2438/14538.

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VSV-G has been used for several years to pseudotype reteroviral and lentiviral vectors to increase the range of cell types that these vectors can be targeted to as well as increasing transfection efficiency and serum resistance. It has previously been shown that purified VSV-G protein can be added to several types of non-viral complexes to produce these same advantages. VSV-G therefore holds great potential in gene therapy for both viral and non-viral vectors. Due to the cellular toxicity of VSV-G in mammalian cells VSV-G pseudotyped viral vectors are generally produced from transiently transf
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Zinselmeyer, Bernd H. "Evaluation of polypropylenimine dendrimers and their quaternary amino derivates as non-viral gene transfer agents." Thesis, University of Strathclyde, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432089.

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Monjezi, Razieh [Verfasser], and Michael [Gutachter] Hudecek. "Engineering of chimeric antigen receptor T cells with enhanced therapeutic index in cancer immunotherapy using non-viral gene transfer and genome editing / Razieh Monjezi ; Gutachter: Michael Hudecek." Würzburg : Universität Würzburg, 2018. http://d-nb.info/1162062231/34.

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Higuti, Eliza. "Correção fenotípica do nanismo avaliada por diferentes parâmetros de crescimento após administração de DNA plasmidial em modelo animal de deficiência isolada do hormônio do crescimento." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/85/85131/tde-07032016-091035/.

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A deficiência de hormônio de crescimento (DGH) é a deficiência mais comum entre os hormônios pituitários. A terapia utilizada atualmente consiste de injeções diárias de hormônio de crescimento humano recombinante (r-hGH), entretanto esta terapia apresenta alguns inconvenientes, como a necessidade de frequentes injeções de r-hGH durante um longo período de vida, dependendo da severidade da deficiência, e o alto custo do hormônio, em razão dos dispendiosos processos de purificação. Uma alternativa ao tratamento padrão seria aquele no qual fossem evitados estes tipos de inconvenientes e o process
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Walther, Wolfgang. "In vitro- und in vivo Untersuchungen für eine nicht-virale und Therapie-regulierbare Tumorgentherapie." Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13932.

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Die Gentherapie hat in den letzten Jahren wesentliche Entwicklungen im Vektordesign, der kontrollierte Expression sowie der Sicherheit ihrer Anwendung durchgemacht. Die Erkenntnis, dass die Tumorgentherapie allein nur in begrenztem Maße zum erhofften therapeutischen Benefit für den Patienten beitragen kann, führte zum Konzept der lokalen Gentherapie als Teil anderer, etablierter Tumortherapien. In diesem Zusammenhang wird die Gentherapie als eine moderne Option zur Steigerung der Effizienz von Chemotherapie, Strahlentherapie oder Hyperthermie verstanden. Zum Erreichen dieses Zieles ist die Eta
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Kobelt, Dennis. "Klinische Studie und experimentelle Untersuchungen zur nicht-viralen Gentherapie solider Tumoren." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2012. http://dx.doi.org/10.18452/16598.

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Krebs gehört zu den häufigsten Todesursachen weltweit. Ein großer Hoffnungsträger für die Behandlung maligner Tumore ist die Gentherapie. Die nicht-virale Gentherapie gilt als sicherere Alternative zur viralen Gentherapie. Für den nicht viralen Gentransfer sind sowohl Vektor als auch Gentransfertechnologie von entscheidender Bedeutung. Im Rahmen dieser Arbeit wurde die Gentransfereffizienz und Sicherheit der Jet-Injektion in einer klinischen Phase I Gentransferstudie mit Hilfe des Swiss-Injektors untersucht. Es konnte gezeigt werden, dass diese Technologie sicher klinisch angewendet werden
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CIOLINA, NEVES CAROLE. "Import et ciblage nucleaire de l'adn plasmidique lors du transfert de gene non viral." Paris 7, 1999. http://www.theses.fr/1999PA077051.

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Differentes etapes limitent l'efficacite du transfert de genes par les vecteurs chimiques. Nous nous sommes plus particulierement interesses a l'import nucleaire de l'adn plasmidique. Une technique de marquage covalent de l'adn plasmidique par photoactivation qui ne perturbe pas l'etat de superenroulement de l'adn a ete mise en place. Des etudes de microinjection de plasmides marques ont montre l'inefficacite du transport plasmidique du cytoplasme vers le noyau, des problemes de degradation et de diffusion de l'adn. Pour guider de l'adn plasmidique jusqu'au noyau, nous avons envisage l'utilisa
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Books on the topic "Non-viral gene transfer"

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(Editor), Kazunari Taira, Kazunori Kataoka (Editor), and Takuro Niidome (Editor), eds. Non-viral Gene Therapy: Gene Design and Delivery. Springer, 2005.

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Schleef, Martin. Minicircle and Miniplasmid DNA Vectors: The Future of Non-Viral and Viral Gene Transfer. Wiley & Sons, Incorporated, John, 2013.

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Leaf, Huang, Hung Mien-chie, and Wagner Ernst 1960-, eds. Non-viral vectors for gene therapy. 2nd ed. Elsevier Academic Press, 2005.

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Thursfield, Rebecca, Chris Orchard, Rosanna Featherstone, and Jane C. Davies. Future treatments. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780198702948.003.0013.

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There are only a relatively limited armoury of drugs, the majority of which are aimed at downstream symptoms of cystic fibrosis. Therapies targeting the basic defect in CF as well as continued availability of more conventional drugs are required. Progress in gene therapy has been limited by the significant barriers to gene transfer of the CF lung, but the UK is hosting a large repeated dose trial of nebulized non-viral gene therapy designed around clinically meaningful outcomes. The UK CF Gene Therapy Consortium is also seeking to develop a promising modified lentiviral approach, although this
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Book chapters on the topic "Non-viral gene transfer"

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Jacobsen, Linda B. "Plasmid and Other Non-Viral Vectors." In Gene Transfer in the Cardiovascular System. Springer US, 1997. http://dx.doi.org/10.1007/978-1-4615-6277-1_4.

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Iyengar, Adarsh, and Seán M. Sullivan. "Development of Neutral Liposome Plasmid DNA Complexes for Gene Transfer: Non-Viral Gene Delivery Systems." In ACS Symposium Series. American Chemical Society, 2004. http://dx.doi.org/10.1021/bk-2004-0879.ch005.

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Chiarella, Pieranna, Vito Michele, and Emanuela Signori. "DNA Vaccination by Electrogene Transfer." In Non-Viral Gene Therapy. InTech, 2011. http://dx.doi.org/10.5772/17648.

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Matte, Ursula, Guilherme Baldo, and Roberto Giugliani. "Non Viral Gene Transfer Approaches for Lysosomal Storage Disorders." In Non-Viral Gene Therapy. InTech, 2011. http://dx.doi.org/10.5772/18106.

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Schleef, Martin. "NON-VIRAL DNA VECTORS." In Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346889_0013.

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Chung, Hea-Jong, Hyun-Seo Lee, Hyeon-Jin Kim, and Seong-Tshool Hong. "The Mechanical Agitation Method of Gene Transfer for Ex-Vivo Gene Therapy." In Non-Viral Gene Therapy. InTech, 2011. http://dx.doi.org/10.5772/21477.

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Dewa, Takehisa, Tomohiro Asai, Naoto Oku, and Mamoru Nango. "Polyamine – Lipid Conjugates as Effective Gene Carriers: Chemical Structure, Morphology, and Gene Transfer Activity." In Non-Viral Gene Therapy. InTech, 2011. http://dx.doi.org/10.5772/18929.

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Schleef, Martin. "12: NON-VIRAL DNA VECTORS." In Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology. IMPERIAL COLLEGE PRESS, 2014. http://dx.doi.org/10.1142/9781848168305_0012.

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Saha, Sunandan, and Matthew H. "Transposons for Non-Viral Gene Transfer." In Gene Therapy - Tools and Potential Applications. InTech, 2013. http://dx.doi.org/10.5772/52527.

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Ericson, Mark, Kevin Rice, and Guy Zuber. "MACROMOLECULAR CONJUGATES FOR NON-VIRAL NUCLEIC ACID DELIVERY." In Advanced Textbook on Gene Transfer, Gene Therapy and Genetic Pharmacology. WORLD SCIENTIFIC (EUROPE), 2019. http://dx.doi.org/10.1142/9781786346889_0014.

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