Relevant bibliographies by topics / Noncoding RNA; miRNA; Biogenesis of miRNA

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers
  6. Reports

Academic literature on the topic 'Noncoding RNA; miRNA; Biogenesis of miRNA'

Author: Grafiati
Published: 5 June 2025
Last updated: 15 July 2025

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Journal articles on the topic "Noncoding RNA; miRNA; Biogenesis of miRNA"

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Chen, Pai-Sheng, Shao-Chieh Lin, and Shaw-Jenq Tsai. "Complexity in regulating microRNA biogenesis in cancer." Experimental Biology and Medicine 245, no. 5 (2020): 395–401. http://dx.doi.org/10.1177/1535370220907314.

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The discovery of microRNA (miRNA) significantly extends our knowledge on gene regulation and noncoding gene functions. MiRNAs are important post-transcriptional regulators involve in a wide range of biological functions and diseases, including cancer. MiRNAs are produced by a unique biogenesis pathway involving the two-step sequential nuclear and cytoplasmic RNase-dependent processing at post-transcriptional level. However, a specific (set) of miRNA(s) is (are) synthesized under certain circumstance or developmental/pathological stage to fine-tune the gene expression profile. In this minirevie
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Kawai, Shinji, and Atsuo Amano. "BRCA1 regulates microRNA biogenesis via the DROSHA microprocessor complex." Journal of Cell Biology 197, no. 2 (2012): 201–8. http://dx.doi.org/10.1083/jcb.201110008.

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MicroRNAs (miRNAs) are noncoding RNAs that function as key posttranscriptional regulators of gene expression. miRNA maturation is controlled by the DROSHA microprocessor complex. However, the detailed mechanism of miRNA biogenesis remains unclear. We show that the tumor suppressor breast cancer 1 (BRCA1) accelerates the processing of miRNA primary transcripts. BRCA1 increased the expressions of both precursor and mature forms of let-7a-1, miR-16-1, miR-145, and miR-34a. In addition, this tumor suppressor was shown to be directly associated with DROSHA and DDX5 of the DROSHA microprocessor comp
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Liu, Zezheng, Mingshu Wang, Anchun Cheng, et al. "Gene regulation in animal miRNA biogenesis." Epigenomics 14, no. 19 (2022): 1197–212. http://dx.doi.org/10.2217/epi-2022-0214.

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miRNAs are a class of noncoding RNAs of approximately 19–22 nucleotides that are widely found in animals, plants, bacteria and even viruses. Dysregulation of the expression profile of miRNAs is importantly linked to the development of diseases. Epigenetic modifications regulate gene expression and control cellular phenotypes. Although miRNAs are used as an epigenetic regulation tool, the biogenesis of miRNAs is also regulated by epigenetic events. Here the authors review the mechanisms and roles of epigenetic modification (DNA methylation, histone modifications), RNA modification and ncRNAs in
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Ying, Shao. "MiR-302: The Multifunctional MicroRNA." Endocrinology and Disorders 3, no. 1 (2019): 01–02. http://dx.doi.org/10.31579/2640-1045/040.

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MicroRNAs (miRNAs) are short single-stranded noncoding RNAs (20- to 25-nucleotide (nt) long) representing a class of small regulatory RNAs. By inhibiting the translation of target mRNAs, miRNAs regulate gene expression posttranscriptionally and thus play an important role in a wide range of cellular processes. Currently, there are two known types of miRNAs: intergenic and intronic miRNAs. Biogenesis of an intergenic miRNA starts with the synthesis of a primary miRNA transcript (pri-miRNA) catalyzed by types-II or -III RNA polymerase (Pol-II/III). Pri-miRNAs are processed in the nucleus by the
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Muggenhumer, Dominik, Cornelia Vesely, Simon Nimpf, Nan Tian, Jin Yongfeng, and Michael F. Jantsch. "Drosha protein levels are translationally regulated during Xenopus oocyte maturation." Molecular Biology of the Cell 25, no. 13 (2014): 2094–104. http://dx.doi.org/10.1091/mbc.e13-07-0386.

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MicroRNAs (miRNAs) are ∼21-nucleotide-long, single-stranded noncoding RNAs that regulate gene expression. Biogenesis of miRNAs is mediated by the two RNase III-like enzymes, Drosha and Dicer. Here we study miRNA biogenesis during maturation of Xenopus oocytes to eggs using microinjection of pri-miRNAs. We show that processing of exogenous and endogenous primary miRNAs (pri-miRNAs) is strongly enhanced upon maturation of oocytes to eggs. Overexpression of cloned Xenopus Drosha in oocytes, however, boosts pri-miRNA processing dramatically, indicating that Drosha is a rate-limiting factor in Xeno
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Bhat, Susheel Sagar, Dawid Bielewicz, Tomasz Gulanicz, et al. "mRNA adenosine methylase (MTA) deposits m6A on pri-miRNAs to modulate miRNA biogenesis inArabidopsis thaliana." Proceedings of the National Academy of Sciences 117, no. 35 (2020): 21785–95. http://dx.doi.org/10.1073/pnas.2003733117.

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InArabidopsis thaliana, the METTL3 homolog, mRNA adenosine methylase (MTA) introducesN6-methyladenosine (m6A) into various coding and noncoding RNAs of the plant transcriptome. Here, we show that an MTA-deficient mutant (mta) has decreased levels of microRNAs (miRNAs) but accumulates primary miRNA transcripts (pri-miRNAs). Moreover, pri-miRNAs are methylated by MTA, and RNA structure probing analysis reveals a decrease in secondary structure within stem–loop regions of these transcripts inmtamutant plants. We demonstrate interaction between MTA and both RNA Polymerase II and TOUGH (TGH), a pla
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Pawlicki, Jan M., and Joan A. Steitz. "Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production." Journal of Cell Biology 182, no. 1 (2008): 61–76. http://dx.doi.org/10.1083/jcb.200803111.

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MicroRNAs (miRNAs) are noncoding RNAs with important roles in regulating gene expression. In studying the earliest nuclear steps of miRNA biogenesis, we observe that primary miRNA (pri-miRNA) transcripts retained at transcription sites due to the deletion of 3′-end processing signals are converted more efficiently into precursor miRNAs (pre-miRNAs) than pri-miRNAs that are cleaved, polyadenylated, and released. Flanking exons, which also increase retention at transcription sites, likewise contribute to increased levels of intronic pri-miRNAs. Consistently, efficiently processed endogenous pri-
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Yoshikawa, Masaru, and Yoichi Robertus Fujii. "Human Ribosomal RNA-Derived Resident MicroRNAs as the Transmitter of Information upon the Cytoplasmic Cancer Stress." BioMed Research International 2016 (2016): 1–14. http://dx.doi.org/10.1155/2016/7562085.

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Dysfunction of ribosome biogenesis induces divergent ribosome-related diseases including ribosomopathy and occasionally results in carcinogenesis. Although many defects in ribosome-related genes have been investigated, little is known about contribution of ribosomal RNA (rRNA) in ribosome-related disorders. Meanwhile, microRNA (miRNA), an important regulator of gene expression, is derived from both coding and noncoding region of the genome and is implicated in various diseases. Therefore, we performedin silicoanalyses using M-fold, TargetScan, GeneCoDia3, and so forth to investigate RNA relati
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Li, Jin, Ying Wang, Lei Wang, et al. "MatPred: Computational Identification of Mature MicroRNAs within Novel Pre-MicroRNAs." BioMed Research International 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/546763.

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Background.MicroRNAs (miRNAs) are short noncoding RNAs integral for regulating gene expression at the posttranscriptional level. However, experimental methods often fall short in finding miRNAs expressed at low levels or in specific tissues. While several computational methods have been developed for predicting the localization of mature miRNAs within the precursor transcript, the prediction accuracy requires significant improvement.Methodology/Principal Findings.Here, we present MatPred, which predicts mature miRNA candidates within novel pre-miRNA transcripts. In addition to the relative loc
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Lin, Shi-Lung, Joseph D. Miller, and Shao-Yao Ying. "Intronic MicroRNA (miRNA)." Journal of Biomedicine and Biotechnology 2006 (2006): 1–13. http://dx.doi.org/10.1155/jbb/2006/26818.

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Nearly 97% of the human genome is composed of noncoding DNA, which varies from one species to another. Changes in these sequences often manifest themselves in clinical and circumstantial malfunction. Numerous genes in these non-protein-coding regions encode microRNAs, which are responsible for RNA-mediated gene silencing through RNA interference (RNAi)-like pathways. MicroRNAs (miRNAs), small single-stranded regulatory RNAs capable of interfering with intracellular messenger RNAs (mRNAs) with complete or partial complementarity, are useful for the design of new therapies against cancer polymor
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Dissertations / Theses on the topic "Noncoding RNA; miRNA; Biogenesis of miRNA"

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Parsons, Aimee. "The relationship between miRNA biogenesis and RNA splicing." Thesis, University of Nottingham, 2018. http://eprints.nottingham.ac.uk/50970/.

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MiRNAs (miRNAs) are important for the proper regulation of translation, with aberrant miRNA expression contributing to diseases such as cancer. MiRNAs are expressed from longer primary-miRNA transcripts and found in a variety of genomic locations, including introns and exons of coding or long noncoding RNAs. MiRNA biogenesis begins with excision of the precursor miRNA hairpin by the Microprocessor complex which consists of two proteins: Drosha and DGCR8. Both Microprocessor cleavage and splicing occur co-transcriptionally. Splicing and Microprocessing coexist when a miRNA hairpin is located wi
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Nowak, Jakub Stanislaw. "Dual role of Lin28a in the regulation of miRNA biogenesis during neuronal differentiation." Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/20393.

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Many cellular functions depend on the tightly regulated expression of various proteins. Canonical control of the protein expression is associated with transcriptional regulation. However, the small non-coding RNAs called microRNAs (miRNAs) were identified as post-transcriptional regulators of gene expression. In a typical manner, miRNAs originate similarly to the coding RNAs and are processed in a multi-step maturation process. It has been shown that miRNAs are very important for the proper functioning of tissues. Interestingly, the human nervous system contains over 70% of all miRNAs; thus, t
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GASPERINI, CATERINA. "Role of small noncoding RNAs in mammalian adult neurogenesis." Doctoral thesis, Università degli studi di Genova, 2020. http://hdl.handle.net/11567/993469.

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Neurogenesis is the process of new neuron (and glia) generation from Neural Stem Cells (NSCs). NSCs self-renew and generate committed offspring in a tightly regulated fashion. The balance between NSC proliferation and differ- entiation guarantees brain formation, lifelong neurogenesis and prevents tumor formation. Regulation of neurogenesis is crucial but remains unclear. Understanding this regulation has implications for comprehending brain (mal)formation, mainte- nance of the capability to generate new neurons throughout life preventing age-related disorders and brain cognition. Adult hipp
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Žigárdi, Tomáš. "Klasifikace malých nekódujících RNA." Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2015. http://www.nusl.cz/ntk/nusl-234981.

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This masters's thesis contains description of designed and implemented tool for classification of plant microRNA without genome. Properties of mature and star sequences in microRNA duplexes are used. Implemented method is based on clustering of RNA sequences (with CD-HIT) to mainly reduce their count. Selected representants from each clusters are classified using support vector machine. Performance of classification is more than 96% (based on cross-validation method using the training data).
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Mirihana, Arachchilage Gayan S. "REGULATORY ROLES OF G-QUADRUPLEX IN microRNA PROCESSING AND mRNA TRANSLATION." Kent State University / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=kent1469576783.

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Books on the topic "Noncoding RNA; miRNA; Biogenesis of miRNA"

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Ørom, Ulf Andersson Vang. MiRNA Biogenesis: Methods and Protocols. Springer New York, 2019.

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miRNA Biogenesis: Methods and Protocols. Springer, 2018.

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Book chapters on the topic "Noncoding RNA; miRNA; Biogenesis of miRNA"

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Tu, Mei-Juan, Halley K. Wright, Neelu Batra, and Ai-Ming Yu. "Expression and of tRNA/pre-miRNA-Based Recombinant Noncoding RNAs." In RNA Scaffolds. Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1499-0_18.

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Ravelonandro, Michel, and Pascal Briard. "Biogenesis and functional RNAi in fruit trees." In RNAi for plant improvement and protection. CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0005.

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Abstract In plants, genome expression is linked to the transcribed mRNAs that are synthesized by RNA polymerase. Following its move to the cytoplasm, the generated mRNA is briefly translated to the encoded protein. If transcription and translation are dependent on the family of RNA polymerase, these two phenomena could be interfered with through the process designated as gene regulation. Thus, large molecules of RNA (single-stranded or double-stranded) consequently sliced into small molecules produce nascent small interfering RNA ranging from 21 to 27 nucleotides. This chapter revisits the biogenesis of these two types of RNAi, miRNA and siRNA, and notably their involvement in plant gene regulation. Following their sequential transcription and their specific involvement, we will consider the sources and roles of RNA interference in plants and we will look at their detection in fruit crops. We discuss their applications and the risk assessment studies in fruit crops.
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Ravelonandro, Michel, and Pascal Briard. "Biogenesis and functional RNAi in fruit trees." In RNAi for plant improvement and protection. CABI, 2021. http://dx.doi.org/10.1079/9781789248890.0040.

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Abstract In plants, genome expression is linked to the transcribed mRNAs that are synthesized by RNA polymerase. Following its move to the cytoplasm, the generated mRNA is briefly translated to the encoded protein. If transcription and translation are dependent on the family of RNA polymerase, these two phenomena could be interfered with through the process designated as gene regulation. Thus, large molecules of RNA (single-stranded or double-stranded) consequently sliced into small molecules produce nascent small interfering RNA ranging from 21 to 27 nucleotides. This chapter revisits the biogenesis of these two types of RNAi, miRNA and siRNA, and notably their involvement in plant gene regulation. Following their sequential transcription and their specific involvement, we will consider the sources and roles of RNA interference in plants and we will look at their detection in fruit crops. We discuss their applications and the risk assessment studies in fruit crops.
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Chowdhury, Parul. "MicroRNA (miRNA) and Small Interfering RNA (siRNA): Biogenesis and Functions in Plants." In Biotic and Abiotic Stress Tolerance in Plants. Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-9029-5_12.

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Heale, Bret S. E., Liam P. Keegan, and Mary A. O’Connell. "The Effect of RNA Editing and ADARs on miRNA Biogenesis and Function." In Advances in Experimental Medicine and Biology. Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7823-3_8.

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Petkevich, Alisa, Aleksandr Abramov, and Vadim Pospelov. "miRNAs in Liver Cancer." In Liver Cancer - Genesis, Progression and Metastasis [Working Title]. IntechOpen, 2022. http://dx.doi.org/10.5772/intechopen.106171.

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miRNAs are small noncoding RNAs, which are involved in epigenetic regulation of gene expression. Hepatocellular carcinoma (HCC), although not being at the top of most widespread cancers, nevertheless, remains among cancers with the most lethal cases. The chapter is dedicated to the epigenetic aspect of HCC development, namely the role of miRNA in this process. Being small and noncoding RNAs, they have a huge and significant function in gene regulation. This chapter will briefly cover following questions: miRNA biogenesis and function, metabolic and signaling pathways disrupted in HCC with a significant miRNA involvement, and main miRNAs contributing to HCC development and their targets.
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Babar Khawar, Muhammad, Huma Rasheed, Ali Afzal, Muddasir Hassan Abbasi, and Nadeem Sheikh. "Functional Role of MicroRNAs in Embryogenesis." In Noncoding RNA - The Dark Matter of the Genome [Working Title]. IntechOpen, 2023. http://dx.doi.org/10.5772/intechopen.112473.

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This book chapter will provide an overview of the functional role of microRNAs (miRNAs) in embryogenesis. A brief introduction to embryogenesis and emphasis on the importance of miRNAs in gene regulation will be provided. The biogenesis and mechanism of action of miRNAs will be discussed in detail with a focus on the importance of miRNA-mRNA interaction in gene regulation. The chapter will then delve into the role of miRNAs in early embryonic development, including their importance in the establishment of the three germ layers, cell proliferation, differentiation, and apoptosis during embryogenesis. The role of miRNAs in organogenesis and tissue differentiation, specifically the formation of specific organs such as the heart, lung, liver, and brain, will also be discussed. The chapter will conclude by examining the dysregulation of miRNAs in embryonic development and disease, including teratogenicity, developmental disorders, and developmental cancer. The chapter will summarize the functional roles of miRNAs in embryogenesis and will offer future perspectives and potential therapeutic applications of miRNAs in embryonic development and disease.
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Águila, Sonia, Ernesto Cuenca-Zamora, Constantino Martínez, and Raúl Teruel-Montoya. "MicroRNAs in Platelets: Should I Stay or Should I Go?" In Platelets. IntechOpen, 2020. http://dx.doi.org/10.5772/intechopen.93181.

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In this chapter, we discuss different topics always using the microRNA as the guiding thread of the review. MicroRNAs, member of small noncoding RNAs family, are an important element involved in gene expression. We cover different issues such as their importance in the differentiation and maturation of megakaryocytes (megakaryopoiesis), as well as the role in platelets formation (thrombopoiesis) focusing on the described relationship between miRNA and critical myeloid lineage transcription factors such as RUNX1, chemokines receptors as CRCX4, or central hormones in platelet homeostasis like TPO, as well as its receptor (MPL) and the TPO signal transduction pathway, that is JAK/STAT. In addition to platelet biogenesis, we review the microRNA participation in platelets physiology and function. This review also introduces the use of miRNAs as biomarkers of platelet function since the detection of pathogenic situations or response to therapy using these noncoding RNAs is getting increasing interest in disease management. Finally, this chapter describes the participation of platelets in cellular interplay, since extracellular vesicles have been demonstrated to have the ability to deliver microRNAs to others cells, modulating their function through intercellular communication, redefining the extracellular vesicles from the so-called “platelet dust” to become mediators of intercellular communication.
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Farrell, Robert E. "miRNA and other noncoding RNAs." In RNA Methodologies. Elsevier, 2023. http://dx.doi.org/10.1016/b978-0-323-90221-2.00035-7.

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Napoli, Debora, and Tommaso Pizzorusso. "miRNA in Neuronal Networks Maturation and Plasticity." In Essentials of Noncoding RNA in Neuroscience. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-804402-5.00012-1.

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Conference papers on the topic "Noncoding RNA; miRNA; Biogenesis of miRNA"

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Silva, Alisson Wilians Teixeira, Sâmera De Souza Breves, and Fernanda Rodrigues Silva. "ATUAÇÃO DOS MICRORNAS NO DESENVOLVIMENTO DE PLANTAS: UMA REVISÃO." In II Congresso Brasileiro de Biologia Molecular On-line. Revista Multidisciplinar em Saúde, 2021. http://dx.doi.org/10.51161/rems/2324.

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Introdução: Os microRNAs são uma importante classe de pequenos RNAs endógenos não codantes. Esses pequenos RNAs (~ 22 nucleotídeos) agem como guia para um complexo ribonucleoprotéico clivar ou inibir o RNA mensageiro, atuando, desta forma, no silenciamento gênico pós-transcricional. Objetivo: O presente trabalho visou realizar uma breve revisão acerca da importância dos miRNAs no desenvolvimento vegetal. Material e Métodos: Desta forma, foi realizado um levantamento bibliográfico nas plataformas Google Scholar, Periódico CAPES, PubMed, Scielo e em livros acadêmicos. As palavras-chave utilizada
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Reports on the topic "Noncoding RNA; miRNA; Biogenesis of miRNA"

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Arazi, Tzahi, Vivian Irish, and Asaph Aharoni. Micro RNA Targeted Transcription Factors for Fruit Quality Improvement. United States Department of Agriculture, 2008. http://dx.doi.org/10.32747/2008.7592651.bard.

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Fruits are unique to flowering plants and represent an important component of human and animal diets. Development and maturation of tomato fruit is a well-programmed process, and yet, only a limited number of factors involved in its regulation have been characterized. Micro-RNAs (miRNAs) are small, endogenous RNAs that regulate gene expression in animals and plants. Plant miRNAs have a vital role in the generation of plant forms through post-transcriptional regulation of the accumulation of developmental regulators, especially transcription factors. Recently, we and others have demonstrated th
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