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Journal articles on the topic 'Nonlinear dose-response regressions'

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Published: 9 March 2023
Last updated: 31 July 2025

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1

Peddada, Shyamal D., and Joseph K. Haseman. "Analysis of Nonlinear Regression Models: A Cautionary Note." Dose-Response 3, no. 3 (2005): dose—response.0. http://dx.doi.org/10.2203/dose-response.003.03.005.

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Regression models are routinely used in many applied sciences for describing the relationship between a response variable and an independent variable. Statistical inferences on the regression parameters are often performed using the maximum likelihood estimators (MLE). In the case of nonlinear models the standard errors of MLE are often obtained by linearizing the nonlinear function around the true parameter and by appealing to large sample theory. In this article we demonstrate, through computer simulations, that the resulting asymptotic Wald confidence intervals cannot be trusted to achieve
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Bovbjerg, Marit L., Anna Maria Siega-Riz, Kelly R. Evenson, and William Goodnight. "Exposure Analysis Methods Impact Associations Between Maternal Physical Activity and Cesarean Delivery." Journal of Physical Activity and Health 12, no. 1 (2015): 37–47. http://dx.doi.org/10.1123/jpah.2012-0498.

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Background:Previous studies report conflicting results regarding a possible association between maternal physical activity (PA) and cesarean delivery.Methods:Seven-day PA recalls were collected by telephone from pregnant women (n = 1205) from North Carolina, without prior cesarean, during 2 time windows: 17 to 22 weeks and 27 to 30 weeks completed gestation. PA was treated as a continuous, nonlinear variable in binomial regressions (log-link function); models controlled for primiparity, maternal contraindications to exercise, preeclampsia, pregravid BMI, and percent poverty. We examined both t
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3

Falchook, Gerald Steven, Johanna C. Bendell, Susanna Varkey Ulahannan, et al. "Pen-866, a miniature drug conjugate of a heat shock protein 90 (HSP90) ligand linked to SN38 for patients with advanced solid malignancies: Phase I and expansion cohort results." Journal of Clinical Oncology 38, no. 15_suppl (2020): 3515. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.3515.

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3515 Background: PEN-866 is a miniature drug conjugate which links a HSP90 binding small molecule to a SN-38 cytotoxic payload. HSP90 is highly expressed in advanced malignancies. PEN-866 targets and binds to activated tumor HSP90 protein, releases its cytotoxic payload, and results in complete tumor regressions in multiple xenograft models. This first-in-human study assessed safety, tolerability, pharmacokinetics (PK), and preliminary efficacy of PEN-866. Methods: Patients (pts) with progressive, advanced solid malignancies were enrolled in escalating cohorts of 2-9 pts. The primary objective
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Bárdossy, András, István Bogárdi, and Lucien Duckstein. "Fuzzy nonlinear regression analysis of dose-response relationships." European Journal of Operational Research 66, no. 1 (1993): 36–51. http://dx.doi.org/10.1016/0377-2217(93)90204-z.

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NIELSEN, OLE K., CHRISTIAN RITZ, and JENS C. STREIBIG. "Nonlinear Mixed-Model Regression to Analyze Herbicide Dose–Response Relationships1." Weed Technology 18, no. 1 (2004): 30–37. http://dx.doi.org/10.1614/wt-03-070r1.

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6

Belz, Regina G., Karl Hurle, and Stephen O. Duke. "Dose-Response—A Challenge for Allelopathy?" Nonlinearity in Biology, Toxicology, Medicine 3, no. 2 (2005): nonlin.003.02.0. http://dx.doi.org/10.2201/nonlin.003.02.002.

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The response of an organism to a chemical depends, among other things, on the dose. Nonlinear dose-response relationships occur across a broad range of research fields, and are a well established tool to describe the basic mechanisms of phytotoxicity. The responses of plants to allelochemicals as biosynthesized phytotoxins, relate as well to nonlinearity and, thus, allelopathic effects can be adequately quantified by nonlinear mathematical modeling. The current paper applies the concept of nonlinearity to assorted aspects of allelopathy within several bioassays and reveals their analysis by no
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Hao, Meng, Shuai Jiang, Jingdong Tang, et al. "Ratio of Red Blood Cell Distribution Width to Albumin Level and Risk of Mortality." JAMA Network Open 7, no. 5 (2024): e2413213. http://dx.doi.org/10.1001/jamanetworkopen.2024.13213.

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ImportanceThe ratio of red blood cell distribution width (RDW) to albumin concentration (RAR) has emerged as a reliable prognostic marker for mortality in patients with various diseases. However, whether RAR is associated with mortality in the general population remains unknown.ObjectivesTo explore whether RAR is associated with all-cause and cause-specific mortality and to elucidate their dose-response association.Design, Setting, and ParticipantsThis population-based prospective cohort study used data from participants in the 1998-2018 US National Health and Nutrition Examination Survey (NHA
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Gutjahr, Georg, and Björn Bornkamp. "Likelihood ratio tests for a dose-response effect using multiple nonlinear regression models." Biometrics 73, no. 1 (2016): 197–205. http://dx.doi.org/10.1111/biom.12563.

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9

Sakiyama, Yojiro, Katsuyo Ohashi, and Yukio Takahashi. "Application of nonlinear regression model to sigmoid dose-response relationship in pharmacological studies." Folia Pharmacologica Japonica 132, no. 4 (2008): 199–206. http://dx.doi.org/10.1254/fpj.132.199.

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10

Meddings, J. B., R. B. Scott, and G. H. Fick. "Analysis and comparison of sigmoidal curves: application to dose-response data." American Journal of Physiology-Gastrointestinal and Liver Physiology 257, no. 6 (1989): G982—G989. http://dx.doi.org/10.1152/ajpgi.1989.257.6.g982.

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A number of physiological or pharmacological studies generate sigmoidal dose-response curves. Ideally, data analysis should provide numerical solutions for curve parameters. In addition, for curves obtained under different experimental conditions, testing for significant differences should be easily performed. We have reviewed the literature over the past 3 years in six journals publishing papers in the field of gastrointestinal physiology and established the curve analysis technique used in each. Using simulated experimental data of known error structure, we have compared these techniques wit
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Liu, Qin, Nancy R. Cook, Anna Bergström, and Chung-Cheng Hsieh. "A two-stage hierarchical regression model for meta-analysis of epidemiologic nonlinear dose–response data." Computational Statistics & Data Analysis 53, no. 12 (2009): 4157–67. http://dx.doi.org/10.1016/j.csda.2009.05.001.

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12

Bogen, Kenneth T. "Low-Dose Dose–Response for In Vitro Nrf2-ARE Activation in Human HepG2 Cells." Dose-Response 15, no. 2 (2017): 155932581769969. http://dx.doi.org/10.1177/1559325817699696.

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Kelch-like ECH-associated protein 1 (Keap1), nuclear factor erythroid 2-like factor 2-related factor 2 (Nrf2), and the antioxidant response element (ARE) are interacting components of a master regulatory signaling pathway that coordinates redox homeostasis, cytoprotective responses, and shifts in stem cell state. This study reexamined detailed dose–response (DR) data reported for in vitro Nrf2-ARE activation in human hepatoblastoma HepG2 cell lines containing either a ARE- bla or ARE- luc reporter at 12 different concentrations of each of 15 chemicals. The normalized study data were combined a
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13

Orsini, Nicola. "Weighted mixed-effects dose–response models for tables of correlated contrasts." Stata Journal: Promoting communications on statistics and Stata 21, no. 2 (2021): 320–47. http://dx.doi.org/10.1177/1536867x211025798.

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Recognizing a dose–response pattern based on heterogeneous tables of contrasts is hard. Specification of a statistical model that can consider the possible dose–response data-generating mechanism, including its variation across studies, is crucial for statistical inference. The aim of this article is to increase the understanding of mixed-effects dose–response models suitable for tables of correlated estimates. One can use the command drmeta with additive (mean difference) and multiplicative (odds ratios, hazard ratios) measures of association. The postestimation command drmeta_graph greatly f
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14

Li, Yuting, Jing Chen, Qingqing Man, et al. "Dose–Response Relationship Between Serum 25(OH)D and the Risk of Abnormal Glycemic Status in Chinese Older Adults." Metabolites 14, no. 11 (2024): 579. http://dx.doi.org/10.3390/metabo14110579.

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Background/Objectives: The relationship between serum 25-hydroxyvitaminD (25(OH)D) concentration and the risk of abnormal glycemic status remains contradictory. Whether sufficient 25(OH)D plays a role in reducing the risk of diabetes and prediabetes is debatable. Its dose–response relationship and the optimal 25(OH)D threshold are not clear. This study investigated the relationship between serum 25(OH)D and the risk of abnormal glycemic status to explore the optimal cut-off value. Methods: This study included 5856 Chinese older adults aged 60 years and above from the China Adult Chronic Diseas
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Jhaveri, Komal, Takako Eguchi Nakajima, Antonio Giordano та ін. "Abstract PS7-03: A first-in-human phase 1a/b trial of LOXO-783, a potent, highly mutant-selective, brain-penetrant, allosteric PI3Kα H1047R inhibitor in PIK3CA H1047R-mutant advanced breast cancer and other solid tumors: Results from the PIKASSO-01 study". Clinical Cancer Research 31, № 12_Supplement (2025): PS7–03—PS7–03. https://doi.org/10.1158/1557-3265.sabcs24-ps7-03.

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Abstract Background: Phosphoinositide 3-kinase alpha (PI3Kα) H1047R mutations occur in ∼15% of breast cancers (BC). Approved treatments for PI3Kα mutant-driven BC include inhibitors of the PI3K/AKT pathway; these block signaling from mutant PI3Kα but also inhibit wild-type PI3Kα leading to dose-limiting toxicities (DLTs) that include hyperglycemia, rash, and GI side effects. Thus, there is a need for novel PI3Kα inhibitors with improved therapeutic indices. LOXO-783 is an oral, brain-penetrant allosteric PI3Kα inhibitor, highly selective for H1047R that induces tumor regressions in ER+, HER2-
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16

Bottai, Matteo, and Giovanna Cilluffo. "Nonlinear parametric quantile models." Statistical Methods in Medical Research 29, no. 12 (2020): 3757–69. http://dx.doi.org/10.1177/0962280220941159.

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Quantile regression is widely used to estimate conditional quantiles of an outcome variable of interest given covariates. This method can estimate one quantile at a time without imposing any constraints on the quantile process other than the linear combination of covariates and parameters specified by the regression model. While this is a flexible modeling tool, it generally yields erratic estimates of conditional quantiles and regression coefficients. Recently, parametric models for the regression coefficients have been proposed that can help balance bias and sampling variability. So far, how
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17

Feder, P. I., C. T. Olson, D. W. Hobson, M. C. Matthews, and R. L. Joiner. "Statistical Analysis of Dose-Response Experiments by Maximum Likelihood Analysis and Iteratively Reweighted Nonlinear Least Squares Regression Techniques." Drug Information Journal 25, no. 3 (1991): 323–34. http://dx.doi.org/10.1177/009286159102500304.

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18

Nan, Yaxing, and Yana Bai. "Sex-Based Differences in the Association between Serum Copper and Kidney Function: Evidence from NHANES 2011–2016." International Journal of Environmental Research and Public Health 19, no. 21 (2022): 14086. http://dx.doi.org/10.3390/ijerph192114086.

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Epidemiological evidence on the relationship between copper (Cu) and kidney function is rare, and few studies examine the sex differences in this association. We aimed to explore the overall and sex-based relationship between exposure to Cu and biomarkers of kidney function among 4331 participants of the 2011–2016 National Health and Nutrition Examination Survey. Multiple linear regression models were fitted to examine the overall and sex-specific associations between serum Cu and the kidney function indicator-estimated glomerular filtration rate (eGFR) and urinary albumin–creatinine ratio (UA
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19

Rusnam and Baskaran Gunasekaran. "Grubb’s Test for the Presence of Outlier in the Four-parameter Logistic Model Used in Obtaining the IC50 Value for Salvia officinalis Extract Against Aeromonas hydrophila." Journal of Environmental Microbiology and Toxicology 7, no. 2 (2019): 32–34. http://dx.doi.org/10.54987/jemat.v7i2.496.

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The current trend in treating fish infection is to reduce the dependency to antibiotics. Active compounds from plants are being intensively studied as potential antibacterial to treat or to prevent infections caused by fish pathogens. A nonlinear regression exercise using the four-parameter dose response variable slope of the inhibition curve of the bacterium Aeromonas hydrophila using solvent extracts from the plant Salvia officinalis is checked for the presence of an outlier [at 95 or 99% of confidence). A potential outlier in a nonlinear regression is actually an extreme data point that is
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20

Yang, Guoyi, Amy M. Mason, Angela M. Wood, C. Mary Schooling, and Stephen Burgess. "Dose-Response Associations of Lipid Traits With Coronary Artery Disease and Mortality." JAMA Network Open 7, no. 1 (2024): e2352572. http://dx.doi.org/10.1001/jamanetworkopen.2023.52572.

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ImportanceApolipoprotein B (apoB), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG) are associated with coronary artery disease (CAD). However, trial evidence for the association of intensive LDL-C lowering and TG lowering with mortality is less definitive.ObjectivesTo investigate the associations of apoB, LDL-C, and TG with CAD and mortality, both overall and by sex and age, and to characterize the shapes of these associations.Design, Setting, and ParticipantsThis genetic association study used linear and nonlinear mendelian randomization (MR) to analyze a population-based
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21

Sorani, Marco D., and Geoffrey T. Manley. "Dose–response relationship of mannitol and intracranial pressure: a metaanalysis." Journal of Neurosurgery 108, no. 1 (2008): 80–87. http://dx.doi.org/10.3171/jns/2008/108/01/0080.

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Object Brain edema can increase intracranial pressure (ICP), potentially leading to ischemia, herniation, and death. Edema and elevated ICP are often treated with osmotic agents to remove water from brain tissue. Mannitol is the osmotic diuretic most commonly used in the intensive care unit; however, despite its clinical importance, treatment protocols vary from center to center, and the dose–response relationship is not understood. The goal of this metaanalysis was to aggregate and analyze data from studies in which authors have described the dose–response relationship between mannitol and IC
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Kawabata, Osamu, and Joseph DeFrank. "A Flexible Function for Regressing Asymptotically Declining Responses of Plant Growth to Growth Retardants." HortScience 29, no. 11 (1994): 1357–59. http://dx.doi.org/10.21273/hortsci.29.11.1357.

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A modified power function, y = (A + B·x)–C, was developed for determining the relationship between plant growth and growth retardant treatment. This function accounts for the plant response characteristics by incorporating three coefficients: A, growth level of the nontreated plants; B, the degree of growth reduction; and C, the smallest effective dose of the growth inhibitor. The function accounted for 97% of the variation in purple nutsedge (Cyperus rotundus L.) leaf length as a function of the amount of a growth retardant applied. The procedure resulted in a smaller error sum of squares tha
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23

Ngan Kee, Warwick D., Kim S. Khaw, Floria F. Ng, Karman K. L. Ng, Rita So, and Anna Lee. "Synergistic Interaction between Fentanyl and Bupivacaine Given Intrathecally for Labor Analgesia." Anesthesiology 120, no. 5 (2014): 1126–36. http://dx.doi.org/10.1097/aln.0000000000000118.

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Abstract Background: Lipophilic opioids and local anesthetics are often given intrathecally in combination for labor analgesia. However, the nature of the pharmacologic interaction between these drugs has not been clearly elucidated in humans. Methods: Three hundred nulliparous women randomly received 1 of 30 different combinations of fentanyl and bupivacaine intrathecally using a combined spinal-epidural technique for analgesia in the first stage of labor. Visual analogue scale pain scores were recorded for 30 min. Response was defined by percentage decrease in pain score from baseline at 15
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Kee, Warwick D. Ngan, Floria F. Ng, Kim S. Khaw, Anna Lee, and Tony Gin. "Determination and Comparison of Graded Dose–Response Curves for Epidural Bupivacaine and Ropivacaine for Analgesia in Laboring Nulliparous Women." Anesthesiology 113, no. 2 (2010): 445–53. http://dx.doi.org/10.1097/aln.0b013e3181bdf9da.

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Background The potencies of bupivacaine and ropivacaine have been compared using up-and-down methodology, but their complete dose-response curves have not been compared. The authors performed a random allocation-graded dose-response study of epidural bupivacaine and ropivacaine given epidurally for labor analgesia. Methods Three hundred laboring nulliparous patients were randomly given epidural bupivacaine (5, 10, 15, 20, 30, or 40 mg) or ropivacaine (7, 15, 20, 30, 45, or 60 mg) in 20 ml of saline. Visual Analog Scale pain scores were recorded for 30 min. Response was defined by the percentag
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Rota, Matteo, Rino Bellocco, Lorenza Scotti, et al. "Random-effects meta-regression models for studying nonlinear dose-response relationship, with an application to alcohol and esophageal squamous cell carcinoma." Statistics in Medicine 29, no. 26 (2010): 2679–87. http://dx.doi.org/10.1002/sim.4041.

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Li, J. M., and J. Kimura. "Translocation mechanism of Na-Ca exchange in single cardiac cells of guinea pig." Journal of General Physiology 96, no. 4 (1990): 777–88. http://dx.doi.org/10.1085/jgp.96.4.777.

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We have studied in single cardiac ventricular cells of guinea pig the ionic translocation mechanism of the electrogenic Na-Ca exchange, i.e., whether Na and Ca ions countercross the membrane simultaneously or consecutively with "ping pong" kinetics. The dose-response relation between the external Ca concentrations [( Ca]o) and the current density of the outward Na-Ca exchange current were measured at three different intracellular Na concentrations [( Na]i) in the absence of external Na. Nonlinear regression curves of the dose-response relation obtained by computer revealed Michaelis-Menten typ
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Hu, Kejia, David Frederick Callen, Jiayuan Li, and Hong Zheng. "Circulating Vitamin D and Overall Survival in Breast Cancer Patients: A Dose-Response Meta-Analysis of Cohort Studies." Integrative Cancer Therapies 17, no. 2 (2017): 217–25. http://dx.doi.org/10.1177/1534735417712007.

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Studies have shown that vitamin D could have a role in breast cancer survival; however, the evidence of the relationship between patients’ vitamin D levels and their survival has been inconsistent. This meta-analysis explores possible dose-response relationships between vitamin D levels and overall survival by allowing for differences in vitamin D levels among populations of the various studies. Studies relating vitamin D (25-OH-D [25-hydroxyvitamin D]) levels in breast cancer patients with their survival were identified by searching PubMed and Embase. A pooled HR (hazard ratio) comparing the
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Ngan Kee, Warwick D. "A Random-allocation Graded Dose–Response Study of Norepinephrine and Phenylephrine for Treating Hypotension during Spinal Anesthesia for Cesarean Delivery." Anesthesiology 127, no. 6 (2017): 934–41. http://dx.doi.org/10.1097/aln.0000000000001880.

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Abstract Background Norepinephrine has been investigated as a potential alterative to phenylephrine for maintaining blood pressure during spinal anesthesia for cesarean delivery with the advantage of less depression of maternal heart rate and cardiac output. However, the relative potencies of these two vasopressors have not been fully determined in this context. Methods In a random-allocation, graded dose–response study, 180 healthy patients undergoing spinal anesthesia for elective cesarean delivery received a single bolus of norepinephrine in one of six different doses ranging from 4 to 12 µ
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Wang, Yi-Jie, Tzu-Lin Yeh, Ming-Chieh Shih, Yu-Kang Tu, and Kuo-Liong Chien. "Dietary Sodium Intake and Risk of Cardiovascular Disease: A Systematic Review and Dose-Response Meta-Analysis." Nutrients 12, no. 10 (2020): 2934. http://dx.doi.org/10.3390/nu12102934.

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Dietary sodium intake has received considerable attention as a potential risk factor of cardiovascular disease. However, evidence on the dose-response association between dietary sodium intake and cardiovascular disease risk is unclear. Embase and PubMed were searched from their inception to 17 August 2020 and studies that examined the association between sodium intake and cardiovascular disease in adolescents were not included in this review. We conducted a meta-analysis to estimate the effect of high sodium intake using a random effects model. The Newcastle-Ottawa Scale assessment was perfor
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Vargas, L., D. S. Fraga, D. Agostinetto, F. Mariani, T. V. Duarte, and B. M. Silva. "Dose-response curves of Lolium multiflorum biotypes resistant and susceptible to clethodim." Planta Daninha 31, no. 4 (2013): 887–92. http://dx.doi.org/10.1590/s0100-83582013000400015.

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Chemical control with herbicides, especially glyphosate, is the main method used to control ryegrass. However, the repeated use of glyphosate has selected resistant ryegrass biotypes. Thus, the ACCase inhibitor herbicides have become the main alternative to control glyphosate-resistant biotypes, being widely used by farmers in Rio Grande do Sul. Repeated use of ACCase inhibitors, in turn, have selected ryegrass biotypes resistant to this herbicide mechanism. Thus, the objective of this study was to evaluate the response of ryegrass biotypes to different clethodim rates by dose-response curves.
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Tian, Zhikui, Xuan Sun, Dongjun Wang, and Hongwu Wang. "Association between color value of tongue and T2DM based on dose-response analyses using restricted cubic splines in China: A cross-sectional study." Medicine 103, no. 25 (2024): e38575. http://dx.doi.org/10.1097/md.0000000000038575.

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This study aimed to explore the relationship between international commission on illumination (CIE) L*a*b* color value of tongue and type 2 diabetes mellitus (T2DM). We used restricted cubic spline method and logistic regression method to assess the relationship between CIE L*a*b* color value of tongue and T2DM. A total of 2439 participants (991 T2DM and 1448 healthy) were included. A questionnaire survey and tongue images obtained with tongue diagnosis analysis-1 were analyzed. As required, chi-square and t tests were applied to compare the T2DM and healthy categories. Our findings suggest th
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Zeng, Xia, Jitian Huang, Tianran Shen, et al. "Nonlinear dose-response association of moderate-to-vigorous physical activity with hyperuricemia in US adults: NHANES 2007–2018." PLOS ONE 19, no. 5 (2024): e0302410. http://dx.doi.org/10.1371/journal.pone.0302410.

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Background The relationship between physical activity and hyperuricemia (HUA) remains inconsistent, and the dose-response association between moderate-to- vigorous physical activity (MVPA) level and HUA still unclear. In this study, we aimed to investigate the dose-response association of MVPA with HUA, and to explore an appropriate range of MVPA level for preventing HUA. Methods Data from the US National Health and Nutrition Examination Survey (NHANES) 2007–2018 were used, including 28740 non-gout adult Americans. MVPA level was self-reported using the Global Physical Activity Questionnaire a
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Harse, Janis D., Kun Zhu, Romola S. Bucks, et al. "Investigating Potential Dose–Response Relationships between Vitamin D Status and Cognitive Performance: A Cross-Sectional Analysis in Middle- to Older-Aged Adults in the Busselton Healthy Ageing Study." International Journal of Environmental Research and Public Health 19, no. 1 (2021): 450. http://dx.doi.org/10.3390/ijerph19010450.

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Low vitamin D status has been linked to adverse cognitive outcomes in older adults. However, relationships at higher levels remain uncertain. We aimed to clarify patterns of association between vitamin D status and cognitive performance, using flexible regression methods, in 4872 middle- to older-aged adults (2678 females) from the Busselton Healthy Ageing Study. Cross-sectional associations of serum levels of 25-hydroxyvitamin D (25OHD) and performance in cognitive domains were modelled using linear regression and restricted cubic splines, controlling for demographic, lifestyle, and health fa
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Taylor, Gregory J., Kenneth J. Stadt, and Mark R. T. Dale. "Modelling the phytotoxicity of aluminum, cadmium, copper, manganese, nickel, and zinc using the Weibull frequency distribution." Canadian Journal of Botany 69, no. 2 (1991): 359–67. http://dx.doi.org/10.1139/b91-049.

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The toxic effects of aluminum, cadmium, copper, manganese, nickel, and zinc stress on root growth of Triticum aestivum were modelled using a modified version of the Weibull frequency distribution. The modified Weibull function is a continuous, nonlinear mathematical function that provides direct estimates of several important biological parameters, including maximum growth, minimum growth, growth response, toxicity threshold, and maximum unit toxicity. The function was fit to experimental data using standard nonlinear regression techniques. Despite variation among metals in the characteristics
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Xu, Minrui, Mingtao Huang, Deren Qiang, et al. "Hypertriglyceridemic Waist Phenotype and Lipid Accumulation Product: Two Comprehensive Obese Indicators of Waist Circumference and Triglyceride to Predict Type 2 Diabetes Mellitus in Chinese Population." Journal of Diabetes Research 2020 (December 2, 2020): 1–12. http://dx.doi.org/10.1155/2020/9157430.

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Purpose. To determine whether hypertriglyceridemic waist (HTGW) and high lipid accumulation product (LAP) preceded the incidence of type 2 diabetes mellitus (T2DM), and to investigate the interactions of HTGW and LAP with other components of metabolic syndrome on the risk of T2DM. Methods. A total of 15,717 eligible participants without baseline T2DM and aged 35 and over were included from a Chinese rural cohort. Cox proportional hazards regression models were used to estimate the association of HTGW and LAP with the incidence of T2DM, and the restricted cubic spline model was used to evaluate
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Li, Juanjuan, Weidi Sun, Zeyu Luo, et al. "Dose-Response Associations of Internet Use Time and Internet Addiction With Depressive Symptoms Among Chinese Children and Adolescents: Cross-Sectional Study." JMIR Public Health and Surveillance 10 (September 23, 2024): e53101-e53101. http://dx.doi.org/10.2196/53101.

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Abstract Background Children’s lives are increasingly mediated by digital technologies, yet evidence regarding the associations between internet use and depression is far from comprehensive and remains unclear. Objective This study aimed to investigate the dose-response association between internet use, including use time and addiction behaviors, and depressive symptoms among children and adolescents in Zhejiang Province. Methods Data were collected from a school-based health survey China Common Disease and Risk Factor Surveillance Among Students, encompassing 21,336 students in Zhejiang Provi
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Vincent, Melissa J., Bruce Allen, Orsolya M. Palacios, Lynne T. Haber, and Kevin C. Maki. "Meta-regression analysis of the effects of dietary cholesterol intake on LDL and HDL cholesterol." American Journal of Clinical Nutrition 109, no. 1 (2018): 7–16. http://dx.doi.org/10.1093/ajcn/nqy273.

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ABSTRACTBackgroundElevated low-density lipoprotein (LDL) cholesterol is a major risk factor for cardiovascular disease. Dietary guidance recommends reducing saturated fatty acid, trans fatty acid, and cholesterol intakes to reduce circulating LDL cholesterol. Cholesterol intake may also affect high-density lipoprotein (HDL)–cholesterol concentrations, but its impact has not been fully quantified.ObjectivesThe aims of this study were to investigate the dose-response relation between changes in dietary cholesterol intake and changes in lipoprotein-cholesterol markers for cardiovascular disease r
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Hibino, Makoto, Yoichiro Otaki, Elsa Kobeissi, et al. "Blood Pressure, Hypertension, and the Risk of Aortic Dissection Incidence and Mortality: Results From the J-SCH Study, the UK Biobank Study, and a Meta-Analysis of Cohort Studies." Circulation 145, no. 9 (2022): 633–44. http://dx.doi.org/10.1161/circulationaha.121.056546.

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Background: Hypertension or elevated blood pressure (BP) is an important risk factor for aortic dissection (AD); however, few prospective studies on this topic have been published. We investigated the association between hypertension/elevated BP and AD in 2 cohorts and conducted a meta-analysis of published prospective studies, including these 2 studies. Methods: We analyzed data from the J-SHC study (Japan-Specific Health Checkups) and UK Biobank, which prospectively followed up 534 378 and 502 424 participants, respectively. Multivariable Cox regression was used to estimate hazard ratios and
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Eng, Jui Yee, Foong Ming Moy, Awang Bulgiba, and Sanjay Rampal. "Dose–Response Relationship between Western Diet and Being Overweight among Teachers in Malaysia." Nutrients 12, no. 10 (2020): 3092. http://dx.doi.org/10.3390/nu12103092.

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The rising prevalence of overweight and obesity is partly due to nutrition transition. The reported association between dietary patterns and overweight/obesity has been controversial because of inconsistent results and weak observed associations. Although it has been hypothesized that an unhealthy diet can increase obesity risk, none of the previous studies have examined the dose–response association using nonlinear dose–response analyses. This study aimed to examine the dose–response association between major dietary patterns and overweight/obesity. This was a cross-sectional study involving
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HOLZHÜTTER, HERMANN-GEORG, and JÖRN QUEDENAU. "MATHEMATICAL MODELLING OF CELLULAR RESPONSES TO EXTERNAL SIGNALS." Journal of Biological Systems 03, no. 01 (1995): 127–38. http://dx.doi.org/10.1142/s0218339095000125.

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An empirical mathematical model is proposed to describe the response (growth rate, metabolic activity etc.) of a cell population to various intensities of an external signal (hormone, antibody, pharmacon etc.). The model is based on the assumption that the signal causes the target system to pass consecutively through i=1, …, N distinct population states having response coefficients Ri. Describing the interaction of the system with the signal according to the rules of chemical kinetics by two phenomenological parameters (k - sensitivity, n - cooperativity index) one arrives at a series expansio
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Wu, HaiTing, XinHua Yuan, and QingSong Fu. "Relationship between sleep quality and duration and the incidence rate of arthritis: A prospective cohort study." Medicine 103, no. 37 (2024): e39641. http://dx.doi.org/10.1097/md.0000000000039641.

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Little is known about the relationship between sleep duration and quality and the risk of arthritis in the older adult population of China. The participants were a prospective cohort of adults aged 65 years and over who had not had arthritis at baseline and had participated in follow-up surveys from 2011 to 2018 in the Chinese Longitudinal Health and Longevity Survey (CLHLS). A Cox proportional-hazards regression model was established. The dose–response relationship between sleep duration and the incidence of arthritis was analyzed. The results of a Cox proportional-risk regression model revea
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GUO, PENGFEI, and ALWELL JULIUS OYET. "ON WAVELET METHODS FOR TESTING EQUALITY OF MEAN RESPONSE CURVES." International Journal of Wavelets, Multiresolution and Information Processing 07, no. 03 (2009): 357–73. http://dx.doi.org/10.1142/s0219691309002969.

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In this article, we exploit the adaptive properties of wavelets to develop some procedures for testing the equality of nonlinear and nonparametric mean response curves which are assumed by an experimenter to be the underlying functions generating several groups of data with possibly hetereoscedastic errors. The essential feature of the techniques is the transformation of the problem from the domain of the input variable to the wavelet domain through an orthogonal discrete wavelet transformation or a multiresolution expansion. We shall see that this greatly simplifies the testing problem into e
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Liu, Menglu, Changchang Fang, Kaibo Mei, et al. "Serum copper and obesity among healthy adults in the National Health and Nutrition Examination Survey." PLOS ONE 19, no. 6 (2024): e0300795. http://dx.doi.org/10.1371/journal.pone.0300795.

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Background Copper (Cu) homeostasis are important processes in the cause of metabolic diseases, but the association between Cu and obesity remains unclear. Methods Participants were drawn from the 2011–2016 National Health and Nutrition Examination Survey (NHANES). Weighted logistic regression assessed the associations of serum Cu concentrations (tertiles) with obesity and central obesity in individuals without comorbidities. Obesity was defined as a BMI ≥30.0 kg/m2, and central obesity was defined as a waist circumference ≥80 cm for women and ≥95 cm for men. Results This cross-sectional study
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Kluess, Heidi A., John B. Buckwalter, Jason J. Hamann, and Philip S. Clifford. "Acidosis attenuates P2X purinergic vasoconstriction in skeletal muscle arteries." American Journal of Physiology-Heart and Circulatory Physiology 288, no. 1 (2005): H129—H132. http://dx.doi.org/10.1152/ajpheart.00574.2004.

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Vasoconstriction via α2-receptors is known to be sensitive to acidic pH, but little is known about the pH sensitivity of P2X receptors. ATP is a cotransmitter released with norepinephrine from the sympathetic nerves and causes vasoconstriction via P2X purinergic receptors on vascular smooth muscle. We hypothesized that reductions in pH would attenuate P2X-mediated vasoconstriction in iliofemoral artery rings. Twenty-five rats were killed, and the iliac and femoral arteries were dissected out and placed in modified Krebs-Henseleit buffer. The arteries were cut into 2-mm sections and mounted in
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Guan, Tianjia, Man Cao, Congyi Zheng, et al. "Dose–response association between physical activity and blood pressure among Chinese adults: a nationwide cross-sectional study." Journal of Hypertension, November 24, 2023. http://dx.doi.org/10.1097/hjh.0000000000003587.

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Objectives: The aim of this study was to examine the dose–response associations of physical activity with blood pressure (BP) and hypertension risk among Chinese adults. Methods: Derived from the national community-based China Hypertension Survey database during 2012--2015, a total of 203 108 residents aged at least 18 years were included. Individual-level physical activity was evaluated using a standardized questionnaire, and minutes of metabolic equivalent tasks per week (MET-min/week) were calculated, integrating domain, intensity, frequency, and duration. Multivariable linear and logistic
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Otaru, Sarah, Laura E. Jones, and David O. Carpenter. "Associations between urine glyphosate levels and metabolic health risks: insights from a large cross-sectional population-based study." Environmental Health 23, no. 1 (2024). http://dx.doi.org/10.1186/s12940-024-01098-8.

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Abstract Background The prevalence of metabolic syndrome (MetS) in American adults increased from 37.6% in the 2011–12 period to 41.8% in 2017–2018. Environmental exposure, particularly to common compounds such as glyphosate, has drawn increasing attention as a potential risk factor. Methods We employed three cycles of data (2013–2018) from the National Health and Nutrition Examination Survey (NHANES) in a cross-sectional study to examine potential associations between urine glyphosate measurements and MetS incidence. We first created a MetS score using exploratory factor analysis (EFA) of the
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Xie, Yaofei, Mengdi Ma, Wenwen Wu, Yupeng Zhang, Yuting Zhang, and Xiaodong Tan. "Dose–response relationship between intergenerational contact frequency and depressive symptoms amongst elderly Chinese parents: a cross-sectional study." BMC Geriatrics 20, no. 1 (2020). http://dx.doi.org/10.1186/s12877-020-01751-0.

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Abstract Background Given the high prevalence of depressive symptoms amongst the elderly Chinese population and the significance of intergenerational contact in this demographic group, the purpose of this study was to examine the association and dose–response relationship between the frequency of intergenerational contact and depressive symptoms. Methods Data were obtained from the third wave of the China Health and Retirement Longitudinal Study. A total of 5791 participants at age 60 or older were included in this study. Depressive symptoms were defined by the 10-item version of the Centre fo
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El Orche, Aimen, Amine Cheikh, Joel B. Johnson, et al. "A novel approach for therapeutic drug monitoring of valproic acid using ATR-FTMIR spectroscopy and non-linear support vector regression." Journal of AOAC INTERNATIONAL, November 11, 2022. http://dx.doi.org/10.1093/jaoacint/qsac146.

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Abstract Background Recent technological progress has bolstered efforts to bring personalized medicine from theory into clinical practice. However, progress in areas such as therapeutic drug monitoring (TDM) has remained somewhat stagnant. In drugs with well-known dose-response relationships, TDM can enhance patient outcomes and reduce health care costs. Traditional monitoring method such as chromatography-based or immunoassay techniques are limited by their higher costs and slow turnaround times, making them unsuitable for real-time or onsite analysis. Objective In this work, we propose the u
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Xu, Yudi, Wenjing Ning, Yuyuan Zhang, et al. "Associations Between Cardiovascular Health (Life's Essential 8) and Mental Disorders." Clinical Cardiology 47, no. 9 (2024). http://dx.doi.org/10.1002/clc.70019.

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ABSTRACTBackgroundMental health was closely associated with cardiovascular disease (CVD). We aimed to investigate the association between cardiovascular health (CVH), as defined by Life's Essential 8 (LE8), and the presence of depression and anxiety.HypothesisWe hypothesized that CVH, as defined by LE8, was negatively associated with the prevalence of depression and anxiety.MethodsA cross‐sectional study was conducted on participants (≥ 20 years old) from the National Health and Nutrition Examination Survey (NHANES). The LE8 score (ranging from 0 to 100) was composed of the health behavior sco
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Ballin, Marcel, Peter Nordström, Johan Niklasson, et al. "Daily step count and incident diabetes in community-dwelling 70-year-olds: a prospective cohort study." BMC Public Health 20, no. 1 (2020). http://dx.doi.org/10.1186/s12889-020-09929-2.

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Abstract Background Older adults with diabetes take fewer steps per day than those without diabetes. The purpose of the present study was to investigate the association of daily step count with incident diabetes in community-dwelling 70-year-olds. Methods This prospective cohort study included N = 3055 community-dwelling 70-year-olds (52% women) who participated in a health examination in Umeå, Sweden during 2012–2017, and who were free from diabetes at baseline. Daily step count was measured for 1 week using Actigraph GT3X+ accelerometers. Cases of diabetes were collected from the Swedish Nat
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