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1

Hidvégi, Tibor. "Az energiamentes édesítőszerek hatása az egyes anyagcsere-paraméterekre." Orvosi Hetilap 157, Supplement 1 (2016): 8–13. http://dx.doi.org/10.1556/oh.2016.30467.

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Nonnutritive sweeteners can be found in many other foods apart from soft drinks. Producers of foodstuffs often use a combination of several sweeteners or sweetener and sugar mixes in a single product mainly to achieve a sweeter taste with a lower calorie count. According to the 2012 Scientific Statement of the American Heart and Diabetes Association, reduction of sugar intake plays an important role in establishing an optimal diet and the maintenance of an appropriate body weight. Controlled intervention studies show that during use of calorie-free sweeteners body weight did not change, moreov
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Geraldo, Ana Paula Gines, and Maria Elisabeth Machado Pinto-e-Silva. "Nonnutritive sweeteners in Brazil: current use and associated factors." Journal of Human Growth and Development 26, no. 3 (2016): 297. http://dx.doi.org/10.7322/jhgd.122760.

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Introduction: The consumption of added sugars has increased worldwide. To guide and encourage the implementation of public policies on the consumption of nonnutritive sweetener (NNS), it is necessary not only to identify the amount consumed of these products, but also the factors associated with their consumption. Objective: This study aimed to identify the variables related to NNS consumption in São Paulo state, Brazil. Method: A cross-sectional study involving adult employees of two public Universities in São Paulo state, Brazil, was conducted. An online questionnaire was applied containing
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Barrios-Correa, Alberto A., José A. Estrada, Caroline Martel, Martin Olivier, Rubén López-Santiago, and Irazú Contreras. "Chronic Intake of Commercial Sweeteners Induces Changes in Feeding Behavior and Signaling Pathways Related to the Control of Appetite in BALB/c Mice." BioMed Research International 2018 (2018): 1–15. http://dx.doi.org/10.1155/2018/3628121.

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Nonnutritive sweetener use is a common practice worldwide. Although considered safe for human consumption, accumulating evidence suggests these compounds may affect metabolic homeostasis; however, there is no consensus on the role of frequent sweetener intake in appetite and weight loss. We sought to determine whether frequent intake of commercial sweeteners induces changes in the JAK2/STAT3 signaling pathway in the brain of mice, as it is involved in the regulation of appetite and body composition. We supplemented adult BALB/c mice with sucrose, steviol glycosides (SG), or sucralose, daily, f
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Parlee, Sebastian D., Becky R. Simon, Erica L. Scheller, et al. "Administration of Saccharin to Neonatal Mice Influences Body Composition of Adult Males and Reduces Body Weight of Females." Endocrinology 155, no. 4 (2014): 1313–26. http://dx.doi.org/10.1210/en.2013-1995.

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Nutritional or pharmacological perturbations during perinatal growth can cause persistent effects on the function of white adipose tissue, altering susceptibility to obesity later in life. Previous studies have established that saccharin, a nonnutritive sweetener, inhibits lipolysis in mature adipocytes and stimulates adipogenesis. Thus, the current study tested whether neonatal exposure to saccharin via maternal lactation increased susceptibility of mice to diet-induced obesity. Saccharin decreased body weight of female mice beginning postnatal week 3. Decreased liver weights on week 14 corro
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AlSuhaibani, Entissar S. "In VivoCytogenetic Studies on Aspartame." Comparative and Functional Genomics 2010 (2010): 1–4. http://dx.doi.org/10.1155/2010/605921.

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Aspartame (a-Laspartyl-L-phenylalanine 1-methylester) is a dipeptide low-calorie artificial sweetener that is widely used as a nonnutritive sweetener in foods and drinks. The safety of aspartame and its metabolic breakdown products (phenylalanine, aspartic acid and methanol) was investigatedin vivousing chromosomal aberration (CA) test and sister chromatid exchange (SCE) test in the bone marrow cells of mice. Swiss Albino male mice were exposed to aspartame (3.5, 35, 350 mg/kg body weight). Bone marrow cells isolated from femora were analyzed for chromosome aberrations and sister chromatid exc
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Ortiz, Semira R., and Martha S. Field. "Chronic Dietary Erythritol Exposure Elevates Plasma Erythritol Concentration in Mice but Does Not Cause Weight Gain or Modify Glucose Homeostasis." Journal of Nutrition 151, no. 8 (2021): 2114–24. http://dx.doi.org/10.1093/jn/nxab130.

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ABSTRACT Background Erythritol is both a common nonnutritive sweetener and an endogenous product of glucose metabolism. Recent reports suggest that elevated plasma erythritol is a predictive biomarker of cardiometabolic disease onset and complications. Objectives Although short-term erythritol consumption has been evaluated, the effect of chronically elevated circulating erythritol on adiposity and glucose metabolism has not. This study investigated the effect of longer-term erythritol consumption on weight gain and glucose tolerance in young/adolescent mice. Methods Four erythritol supplement
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Sylvetsky, Allison C., and Kristina I. Rother. "Nonnutritive Sweeteners in Weight Management and Chronic Disease: A Review." Obesity 26, no. 4 (2018): 635–40. http://dx.doi.org/10.1002/oby.22139.

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8

Benton, David. "Can artificial sweeteners help control body weight and prevent obesity?" Nutrition Research Reviews 18, no. 1 (2005): 63–76. http://dx.doi.org/10.1079/nrr200494.

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AbstractThe possible role played by artificial sweeteners in the long-term maintenance of body weight is considered. Although artificial sweeteners can play a role in a short-term energy-controlled diet, the evidence that they are helpful over a longer period is limited. In those in the recommended weight range there is evidence of compensation; that is, the consumption of low-energy foods is followed by an increased energy intake to make up the lost energy. Energy compensation is more likely in those not displaying dietary restraint. The desire to remove sugar from the diet reflects an assump
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9

Farup, Per G., Stian Lydersen, and Jørgen Valeur. "Are Nonnutritive Sweeteners Obesogenic? Associations between Diet, Faecal Microbiota, and Short-Chain Fatty Acids in Morbidly Obese Subjects." Journal of Obesity 2019 (October 1, 2019): 1–8. http://dx.doi.org/10.1155/2019/4608315.

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Obesity has been associated with changes in the gut microbiota and its metabolites. The study explored changes in the faecal microbiota and short-chain fatty acids (SCFA) associated with the diet (including nonnutritive sweeteners (NNSs)) and evaluated metabolic consequences in subjects with morbid obesity. The diet was assessed with a validated food frequency questionnaire. One unit of NNSs was 100 mL beverage with NNSs or 2 tablets/teaspoons of NNSs. The faecal microbiota was assessed with GA-map® dysbiosis test and SCFA with gas chromatography and flame ionisation detection. Fourteen men an
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10

Bellisle, F., and A. Drewnowski. "Intense sweeteners, energy intake and the control of body weight." European Journal of Clinical Nutrition 61, no. 6 (2007): 691–700. http://dx.doi.org/10.1038/sj.ejcn.1602649.

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11

Normand, Mie, Christian Ritz, David Mela, and Anne Raben. "Low-energy sweeteners and body weight: a citation network analysis." BMJ Nutrition, Prevention & Health 4, no. 1 (2021): 319–32. http://dx.doi.org/10.1136/bmjnph-2020-000210.

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ObjectiveReviews on the relationship of low-energy sweeteners (LES) with body weight (BW) have reached widely differing conclusions. To assess possible citation bias, citation analysis was used to quantify the relevant characteristics of cited articles, and explore citation patterns in relation to review conclusions.DesignA systematic search identified reviews published from January 2010 to March 2020. Different characteristics (for example, type of review or research, journal impact factor, conclusions) were extracted from the reviews and cited articles. Logistic regression was used to estima
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Gupta, Geetika, Sabita Yograj, Anil K. Gupta, Bhavna Langer, Mumtaz Goni, and Lila Kalsotra. "Relationship between intake of artificial sweeteners and body mass index in young non-diabetic adults: a cross-sectional study." International Journal of Research in Medical Sciences 5, no. 4 (2017): 1208. http://dx.doi.org/10.18203/2320-6012.ijrms20170926.

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Background: Artificial sweeteners have skyrocketed the market in the last decade and there are unlimited products available today that contain them. They are often projected as one of the easy and effortless method of cutting down calories and have gained importance in the community. They are being used as one of the dietary tools to control or prevent weight gain not only in diabetic adults but also in young healthy adults and children. There is a need to examine any possible contribution of these substances on body weight and BMI of an individual.Methods: A cross sectional study was conducte
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PORIKOS, K., and H. KOOPMANS. "The effect of non-nutritive sweeteners on body weight in rats." Appetite 11 (1988): 12–15. http://dx.doi.org/10.1016/0195-6663(88)90037-2.

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Porikos, Katherine P., and Henry S. Koopmans. "The effect of non-nutritive sweeteners on body weight in rats." Appetite 11 (January 1988): 12–15. http://dx.doi.org/10.1016/s0195-6663(88)80040-0.

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15

Polyák, Éva, K. Gombos, B. Hajnal, et al. "Effects of artificial sweeteners on body weight, food and drink intake." Acta Physiologica Hungarica 97, no. 4 (2010): 401–7. http://dx.doi.org/10.1556/aphysiol.97.2010.4.9.

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16

Bissonnette, David J., Samantha List, Penny Knoblich, and M. Hadley. "The Effect of Nonnutritive Sweeteners Added to a Liquid Diet on Volume and Caloric Intake and Weight Gain in Rats." Obesity 25, no. 9 (2017): 1556–63. http://dx.doi.org/10.1002/oby.21920.

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17

Swithers, S. E., C. R. Baker, M. Mccurley, and T. L. Davidson. "Persistent effects of high-intensity sweeteners on body weight gain in rats." Appetite 51, no. 2 (2008): 403. http://dx.doi.org/10.1016/j.appet.2008.04.235.

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18

Renwick, A. G. "Intense sweeteners, food intake, and the weight of a body of evidence." Physiology & Behavior 55, no. 1 (1994): 139–43. http://dx.doi.org/10.1016/0031-9384(94)90021-3.

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19

Elobeid, Mai. "Sweeteners as Causative factors of Obesity in Rats: Increased Body Weight, Body Fat and Glucose levels." Surgery for Obesity and Related Diseases 11, no. 6 (2015): S187. http://dx.doi.org/10.1016/j.soard.2015.08.295.

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20

Burke, Mary V., and Dana M. Small. "Physiological mechanisms by which non-nutritive sweeteners may impact body weight and metabolism." Physiology & Behavior 152 (December 2015): 381–88. http://dx.doi.org/10.1016/j.physbeh.2015.05.036.

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21

Rolls, B. J. "Effects of intense sweeteners on hunger, food intake, and body weight: a review." American Journal of Clinical Nutrition 53, no. 4 (1991): 872–78. http://dx.doi.org/10.1093/ajcn/53.4.872.

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22

Pan, An, and Frank B. Hu. "Question about a recent meta-analysis of low-calorie sweeteners and body weight." American Journal of Clinical Nutrition 100, no. 6 (2014): 1604. http://dx.doi.org/10.3945/ajcn.114.098772.

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23

Ramos-García, Meztli, Jorge Luis Ble-Castillo, Carlos García-Vázquez, et al. "Effects of Non-Nutritive Sweeteners on Energy Intake, Body Weight and Postprandial Glycemia in Healthy and with Altered Glycemic Response Rats." Foods 10, no. 5 (2021): 958. http://dx.doi.org/10.3390/foods10050958.

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The aim of this study was to evaluate the effects of non-nutritive sweeteners (NNS) consumption on energy intake, body weight and postprandial glycemia in healthy and with altered glycemic response rats. Animals on normal diet (ND) or high-fat diet (HFD) were divided to receive NNS (sucralose, aspartame, stevia, rebaudioside A) or nutritive sweeteners (glucose, sucrose) for 8 weeks. The NNS were administered at doses equivalent to the human acceptable daily intake (ADI). A test using rapidly digestible starch was performed before and after treatments to estimate glycemic response. No effects o
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Rosales-Gómez, Cristian Angel, Beatriz Elina Martínez-Carrillo, Aldo Arturo Reséndiz-Albor, et al. "Chronic Consumption of Sweeteners and Its Effect on Glycaemia, Cytokines, Hormones, and Lymphocytes of GALT in CD1 Mice." BioMed Research International 2018 (April 24, 2018): 1–15. http://dx.doi.org/10.1155/2018/1345282.

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Background. The consumption of sweeteners has increased in recent years, being used to control body weight and blood glucose. However, they can cause increased appetite, modification of immune function, and secretion of hormones in the GALT. Objective. To assess the effect of chronic sweetener consumption on glycaemia, cytokines, hormones, and GALT lymphocytes in CD1 mice. Material and Methods. 72 CD1 mice divided into 3 groups were used: (a) baseline, (b) middle, and (c) final. Groups (b) and (c) were divided into 4 subgroups: (i) Control, (ii) Sucrose, (iii) Sucralose, and (iv) Stevia. The f
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Zhang, Xiao-Jun, Øivind Irtun, Yaoqing Zheng, and Robert R. Wolfe. "Methysergide reduces nonnutritive blood flow in normal and scalded skin." American Journal of Physiology-Endocrinology and Metabolism 278, no. 3 (2000): E452—E461. http://dx.doi.org/10.1152/ajpendo.2000.278.3.e452.

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Methysergide is a serotonin antagonist and has been demonstrated to reduce wound blood flow and edema formation. We have determined the effect of methysergide on protein kinetics in normal and scalded skin of anesthetized rabbits.l-[ ring-13C6]- orl-[ ring-2H5]phenylalanine was used to reflect skin protein kinetics by use of an ear model, andl-[1-13C]leucine was used to reflect whole body protein kinetics. The results were that infusion of methysergide (2–3 mg ⋅ kg− 1 ⋅ h− 1) reduced the blood flow rate in normal skin by 50% without changing skin or whole body protein kinetics. After scald inj
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Glendinning, John I., Stephanie Hart, Hyunseo Lee, et al. "Low-calorie sweeteners cause only limited metabolic effects in mice." American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 318, no. 1 (2020): R70—R80. http://dx.doi.org/10.1152/ajpregu.00245.2019.

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There are widespread concerns that low-calorie sweeteners (LCSs) cause metabolic derangement. These concerns stem in part from prior studies linking LCS consumption to impaired glucose tolerance in humans and rodents. Here, we examined this linkage in mice. In experiment 1, we provided mice with chow, water, and an LCS-sweetened solution (saccharin, sucralose, or acesulfame K) for 28 days and measured glucose tolerance and body weight across the exposure period. Exposure to the LCS solutions did not impair glucose tolerance or alter weight gain. In experiment 2, we provided mice with chow, wat
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Tovar, Ashley P., James W. Navalta, Laura J. Kruskall, and John C. Young. "The effect of moderate consumption of non-nutritive sweeteners on glucose tolerance and body composition in rats." Applied Physiology, Nutrition, and Metabolism 42, no. 11 (2017): 1225–27. http://dx.doi.org/10.1139/apnm-2017-0120.

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Glucose tolerance and body composition were determined in male rats given non-nutritive sweeteners (NNS) (aspartame or sucralose) in drinking water. Areas under the curve for glucose and insulin with NNS did not differ from control. NNS treatment had no effect on weight gain or percent body fat. Epididymal fat pad mass was higher with aspartame and the ratio of trunk to total fat was less with sucralose versus control, suggesting that NNS consumption altered body fat distribution.
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Renwick, Andrew G., and Samuel V. Molinary. "Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release." British Journal of Nutrition 104, no. 10 (2010): 1415–20. http://dx.doi.org/10.1017/s0007114510002540.

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The present review explores the interactions between sweeteners and enteroendocrine cells, and consequences for glucose absorption and insulin release. A combination of in vitro,in situ, molecular biology and clinical studies has formed the basis of our knowledge about the taste receptor proteins in the glucose-sensing enteroendocrine cells and the secretion of incretins by these cells. Low-energy (intense) sweeteners have been used as tools to define the role of intestinal sweet-taste receptors in glucose absorption. Recent studies using animal and human cell lines and knockout mice have show
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Phifer, C. B., C. R. Sikes, and W. G. Hall. "Control of ingestion in 6-day-old rat pups: termination of intake by gastric fill alone?" American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 250, no. 5 (1986): R807—R814. http://dx.doi.org/10.1152/ajpregu.1986.250.5.r807.

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Six-day-old rat pups, tested away from the dam, vigorously ingested orally infused milk for up to 90 min when the ingested milk was allowed to drain through a gastric fistula. Total intake in pups with unplugged fistulas was more than double that consumed by littermates with plugged fistulas. This persistent feeding could not be due to the absence of postgastric cues because blocking movement of the milk into the intestine with a closed pyloric noose resulted in less intake than when the noose was open. Furthermore, a 5% body weight gastric preload of milk or nonnutritive saline suppressed int
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Higgins, Kelly A., and Richard D. Mattes. "A randomized controlled trial contrasting the effects of 4 low-calorie sweeteners and sucrose on body weight in adults with overweight or obesity." American Journal of Clinical Nutrition 109, no. 5 (2019): 1288–301. http://dx.doi.org/10.1093/ajcn/nqy381.

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ABSTRACT Background Low-calorie sweeteners (LCSs) provide sweetness with little or no energy. However, each LCS's unique chemical structure has potential to elicit different sensory, physiological, and behavioral responses that affect body weight. Objective The purpose of this trial was to compare the effects of consumption of 4 LCSs and sucrose on body weight, ingestive behaviors, and glucose tolerance over a 12-wk intervention in adults (18–60 y old) with overweight or obesity (body mass index 25–40 kg/m2). Methods In a parallel-arm design, 154 participants were randomly assigned to consume
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Sandeva, Rositsa V., Stanislava M. Mihaylova, Gergana N. Sandeva, Katya Y. Trifonova, and Ruska D. Popova-Katsarova. "Effect Of High-Fructose Solution On Body Weight, Body Fat, Blood Glucose And Triglyceride Levels In Rats." Journal of Biomedical and Clinical Research 8, no. 1 (2015): 5–8. http://dx.doi.org/10.1515/jbcr-2015-0143.

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Summary In Europe, as well as in Bulgaria, consumption of soft drinks and confectionery has increased during the last three decades and is partly responsible for the epidemic-like increase in obesity. These foods, originally sweetened by sucrose, are now sweetened by other caloric sweeteners such as fructose. In this study we investigated the effect of an eight-week intake of 20% fructose solution on body weight in rats. Two adult rat groups (aged 120±6 days) of Wistar line were studied: a Control group (C; n=10; 5 male and 5 female rats) received water and standard rodent chow, and a Fructose
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Prokic, Marko, Milica Paunovic, Milos Matic, et al. "Effect of aspartame on biochemical and oxidative stress parameters in rat blood." Archives of Biological Sciences 67, no. 2 (2015): 535–45. http://dx.doi.org/10.2298/abs141009016p.

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Aspartame (ASP) is one of the most widely used nonnutritive sweeteners. This study investigates the chronic effects of ASP on hematological and biochemical parameters, and its effects on the oxidative/antioxidative status in the red blood cells of Wistar albino rats. Rats were provided with ASP (40 mg/kg/daily for six weeks) in drinking water. Increased food and fluid intake was observed in the ASP-treated rats. Total body mass was significantly decreased in the ASP-treated rats. Treatment with ASP caused an increase in the concentrations of glucose, cholesterol, LDL-cholesterol, and in the ac
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Ashwell, Margaret, Sigrid Gibson, France Bellisle, et al. "Expert consensus on low-calorie sweeteners: facts, research gaps and suggested actions." Nutrition Research Reviews 33, no. 1 (2020): 145–54. http://dx.doi.org/10.1017/s0954422419000283.

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AbstractA consensus workshop on low-calorie sweeteners (LCS) was held in November 2018 where seventeen experts (the panel) discussed three themes identified as key to the science and policy of LCS: (1) weight management and glucose control; (2) consumption, safety and perception; (3) nutrition policy. The aims were to identify the reliable facts on LCS, suggest research gaps and propose future actions. The panel agreed that the safety of LCS is demonstrated by a substantial body of evidence reviewed by regulatory experts and current levels of consumption, even for high users, are within agreed
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Hunter, Stephanie R., Evan J. Reister, Eunjin Cheon, and Richard D. Mattes. "Low Calorie Sweeteners Differ in Their Physiological Effects in Humans." Nutrients 11, no. 11 (2019): 2717. http://dx.doi.org/10.3390/nu11112717.

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Low calorie sweeteners (LCS) are prevalent in the food supply for their primary functional property of providing sweetness with little or no energy. Though tested for safety individually, there has been extremely limited work on the efficacy of each LCS. It is commonly assumed all LCS act similarly in their behavioral and physiological effects. However, each LCS has its own chemical structure that influences its metabolism, making each LCS unique in its potential effects on body weight, energy intake, and appetite. LCS may have different behavioral and physiological effects mediated at the swe
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Rogers, Peter J. "The role of low-calorie sweeteners in the prevention and management of overweight and obesity: evidence v. conjecture." Proceedings of the Nutrition Society 77, no. 3 (2017): 230–38. http://dx.doi.org/10.1017/s0029665117004049.

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By virtue of reducing dietary energy density, low-calorie sweeteners (LCS) can be expected to decrease overall energy intake and thereby decrease body weight. Such effects will be limited by the amount of sugar replaced by LCS, and the dynamics of appetite and weight control (e.g., acute compensatory eating, and an increase in appetite and decrease in energy expenditure accompanying weight loss). Consistent with these predictions, short-term intervention studies show incomplete compensation for the consumption of LCS v. sugar, and longer-term intervention studies (from 4 weeks to 40 months dur
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Swithers, Susan E., Chelsea R. Baker, and T. L. Davidson. "General and persistent effects of high-intensity sweeteners on body weight gain and caloric compensation in rats." Behavioral Neuroscience 123, no. 4 (2009): 772–80. http://dx.doi.org/10.1037/a0016139.

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Mathews, Suresh, Mary Kate Brown, Shelby Brown, Madeline Gammon, and Katie Coate. "Effect of Short-Term Normal-Dose and High-Dose Aspartame Consumption on Sweet-Taste Preference Among College-Aged Students." Current Developments in Nutrition 4, Supplement_2 (2020): 547. http://dx.doi.org/10.1093/cdn/nzaa046_047.

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Abstract Objectives The consumption of non-nutritive sweeteners (NNS) through foods and beverages have increased worldwide. The effects of NNS consumption on body weight, glycemic control, or type 2 diabetes incidence are not well understood. While studies in animal models suggest potentially harmful effects of NNS on metabolic health, randomized controlled trials in humans suggest moderate benefits of NNS use on body weight. The relationship between artificial sweeteners and metabolic disease may be linked to their purported effects on sweet taste preference. The Evidence Analysis Library of
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Farhat, Grace, Fleur Dewison, and Leo Stevenson. "Knowledge and Perceptions of Non-Nutritive Sweeteners Within the UK Adult Population." Nutrients 13, no. 2 (2021): 444. http://dx.doi.org/10.3390/nu13020444.

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Non-nutritive sweeteners (NNS) are popular sugar substitutes that can help in weight and diabetes management, but concerns regarding their use have been raised by the public. This study aimed to investigate knowledge, benefits and safety perceptions of NNS in a sample of UK adults. The impact of knowledge dissemination on the change in perceptions was also examined. An online survey was distributed through social media platforms and UK Universities and was completed by 1589 participants aged 18 years and above. Results showed a high-risk perception of NNS and a lack of knowledge in regulations
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Li, X. F., M. H. Hu, B. P. Hanley, et al. "The Posterodorsal Medial Amygdala Regulates the Timing of Puberty Onset in Female Rats." Endocrinology 156, no. 10 (2015): 3725–36. http://dx.doi.org/10.1210/en.2015-1366.

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Obesity is the major risk factor for early puberty, but emerging evidence indicates other factors including psychosocial stress. One key brain region notable for its role in controlling calorie intake, stress, and behavior is the amygdala. Early studies involving amygdala lesions that included the medial nucleus advanced puberty in rats. More recently it was shown that a critical site for lesion-induced hyperphagia and obesity is the posterodorsal subnucleus of the medial amygdala (MePD), which may explain the advancement of puberty. Glutamatergic activity also increases in the MePD during pub
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KANAREK, R., and R. MARKSKAUFMAN. "Factors influencing the effects of nutritive and non-nutritive sweeteners on energy intake and body weight in rats." Appetite 11 (1988): 16–19. http://dx.doi.org/10.1016/0195-6663(88)90038-4.

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Kanarek, Robin B., and Robin Marks-Kaufman. "Factors influencing the effects of nutritive and non-nutritive sweeteners on energy intake and body weight in rats." Appetite 11 (January 1988): 16–19. http://dx.doi.org/10.1016/s0195-6663(88)80041-2.

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42

Perez-Palencia, Jorge Y., Xixi Chen, Jirong Lv, et al. "PSIV-19 Flavors and Sweeteners in Nursery Pig Diets Increased Intake and Reduced Soft Feces in the First Weeks After Weaning." Journal of Animal Science 99, Supplement_1 (2021): 179–80. http://dx.doi.org/10.1093/jas/skab054.303.

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Abstract The stressful events associated with weaning predispose piglets to reduced feed intake, which in concert with immature digestive and immune systems, results in increased incidences of diarrhea and poor performance. Flavors and sweeteners can be used in diets for young pigs as a means of attracting them to dry feed and increase their feed intake and performance after weaning. The objective of this study was to evaluate the effects of dietary inclusion of flavors and sweeteners and their combination on growth performance and post-weaning gut health of nursery pigs. A total of 1,144 wean
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Nogueira-de-Almeida, Carlos Alberto, and Durval Ribas Filho. "Positioning on the Use of Polyols as Table Sweeteners." International Journal of Nutrology 14, no. 02 (2021): e71-e80. http://dx.doi.org/10.1055/s-0041-1733907.

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AbstractPolyols are poorly digestible carbohydrates present in small amounts in some fruits and vegetables. Xylitol and erythritol are used as table sweeteners. These compounds are widely used in the food industry due to their low-calorie content. Erythritol is the only noncaloric polyol. Xylitol is the sweetest of the polyols, being the only one with sweetness equivalent to sucrose, but with one third of its calories. Clinical studies have shown reductions in the number of plaques, in counts of Streptococcus mutans, and in the number of dental cavities in individuals receiving erythritol and
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Roy, S. L., T. L. Davidson, and S. E. Swithers. "The effects of high-intensity sweeteners (saccharin and acesulfame potassium) on food intake and body weight regulation in rats." Appetite 49, no. 1 (2007): 325. http://dx.doi.org/10.1016/j.appet.2007.03.171.

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45

Miller, Paige E., and Vanessa Perez. "Low-calorie sweeteners and body weight and composition: a meta-analysis of randomized controlled trials and prospective cohort studies." American Journal of Clinical Nutrition 100, no. 3 (2014): 765–77. http://dx.doi.org/10.3945/ajcn.113.082826.

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46

Goran, M. I., J. F. Plows, and E. E. Ventura. "Effects of consuming sugars and alternative sweeteners during pregnancy on maternal and child health: evidence for a secondhand sugar effect." Proceedings of the Nutrition Society 78, no. 3 (2018): 262–71. http://dx.doi.org/10.1017/s002966511800263x.

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Consumption of sugar and alternative low- or no-energy sweeteners has increased in recent decades. However, it is still uncertain how consumption of sugar and alternative sweeteners during pregnancy affects pregnancy outcomes and long-term offspring health. This review aims to collate the available evidence surrounding the consequences of sugar and alternative sweetener consumption during pregnancy, a so-called secondhand sugar effect. We found evidence that sugar consumption during pregnancy may contribute to increased gestational weight gain and the development of pregnancy complications, in
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Mosdøl, Annhild, Gunn Elisabeth Vist, Camilla Svendsen, et al. "Hypotheses and evidence related to intense sweeteners and effects on appetite and body weight changes: A scoping review of reviews." PLOS ONE 13, no. 7 (2018): e0199558. http://dx.doi.org/10.1371/journal.pone.0199558.

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Muhammed, Dauda, Yetunde H. Adebiyi, Bernard O. Odey, et al. "Nutritional Management of Diabetes Mellitus: An appraisal of the role of Medicinal plants." AROC in Natural Products Research 01, no. 01 (2021): 01–27. http://dx.doi.org/10.53858/arocnpr01010127.

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Diabetes mellitus is a heterogeneous metabolic syndrome characterized by chronic hyperglycemia with partial or total lack of insulin secretion and insulin resistance. The most common symptoms are polydipsia, polyuria, blurred vision, slow healing sore, nerve damage. Diabetes, being a metabolic, endocrine disorder is directly connected to carbohydrates, lipid, and protein metabolism. As a result, nutrition therapy forms an integral part of diabetes management. Daily caloric intake of 50% - 55% carbohydrates is recommended. Carbohydrate with low glycaemic index is preferred to those with high gl
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Martínez, Ximena, Yazmín Zapata, Victoria Pinto, et al. "Intake of Non-Nutritive Sweeteners in Chilean Children after Enforcement of a New Food Labeling Law that Regulates Added Sugar Content in Processed Foods." Nutrients 12, no. 6 (2020): 1594. http://dx.doi.org/10.3390/nu12061594.

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After enforcement of a new food labeling law in 2016, Chile exhibits a greater offer to reduced sugar products with addition of non-nutritive sweeteners (NNS). Many of these products are consumed by children, who are at greater risk of reaching the acceptable daily intake (ADI) of these food additives. The objective of this study was to evaluate the intake levels of NNS in Chilean schoolchildren after the enactment of the aforementioned law. A total of 250 Chilean children 6–12 years old were surveyed. NNS intake was assessed through a food frequency questionnaire. All children evaluated consu
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Cheung, Annette, Danielle Lee, Nema McGlynn, et al. "Important Food Sources of Sugars and Body Weight: A Systematic Review and Meta-Analysis of Controlled Feeding Trials." Current Developments in Nutrition 4, Supplement_2 (2020): 1620. http://dx.doi.org/10.1093/cdn/nzaa063_018.

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Abstract Objectives Sugar-sweetened beverages (SSBs) have been linked to weight gain, and it is unclear if other food sources of fructose-containing sugars behave similarily. We conducted a systematic review and meta-analysis of controlled feeding trials to assess the effect of different food sources of fructose-containing sugars on body weight. Methods MEDLINE, EMBASE, and The Cochrane library were searched through January 2019. We included controlled feeding trials of ≥2 weeks investigating the effect of different food sources of sugars. Four levels of energy control were prespecified: subst
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