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Dissertations / Theses on the topic 'Nontypeable Haemophilus influenzae'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Tsao, David L. "Serum resistance of an invasive nontypeable H. influenzae." Diss., Columbia, Mo. : University of Missouri-Columbia, 2004. http://hdl.handle.net/10355/5808.

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Thesis (M.S.)--University of Missouri-Columbia, 2004.<br>"December, 2004." The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Includes bibliographical references.

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2

Puig, Pitarch Carmen. "Nontypeable Haemophilus influenzae: colonization, infection and biofilm formation." Doctoral thesis, Universitat de Barcelona, 2015. http://hdl.handle.net/10803/311616.

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Haemophilus influenzae is an opportunistic pathogen that forms part of the human nasopharyngeal microbiota. This microorganism is classified into encapsulated and nonencapsulated or nontypeable (NTHi) isolates, depending on the presence of a polysaccharide capsule. Although H. influenzae is a common respiratory commensal, it is also able to cause several infections, especially in patients with comorbidities. The most common respiratory infections in which H. influenzae can be identified as the main etiological agent are exacerbations in patients with Chronic Obstructive Pulmonary Disease (COPD

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3

Kunthalert, Duangkamol, and n/a. "Immunological and structural characterisation of the nontypeable Haemophilus influenzae vaccine protein OMP26." University of Canberra. Health Sciences, 2004. http://erl.canberra.edu.au./public/adt-AUC20060406.101830.

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Nontypeable Haemophilus influenzas (NTHi) is recognised as a significant human pathogen causing mild to severe respiratory tract infections. At present, no vaccine is available for prevention of infection caused by this pathogen. Several outer membrane proteins (OMPs) of NTHi and its lipooligosaccharide have been investigated as possible vaccine antigens against NTHi infections. Previous investigations in our laboratory have shown that OMP26 from an NTHi 289 strain was able to significantly enhance pulmonary clearance of NTHi in a rat model in which animals were immunised via intestinal Peyer'

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4

Foxwell, Alice Ruth, and n/a. "Mechanisms of immunity to nontypeable Haemophilus influenzae in the lung." University of Canberra. Applied Science, 1998. http://erl.canberra.edu.au./public/adt-AUC20060710.142114.

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Pulmonary infection caused by nontypeable Haemophilus influenzae (NTHi) is a significant cause of morbidity and mortality in both industrialised and developing countries. Previous work from this group resulted in the development of a respiratory model in rodents which has precipitated studies into the pathogenesis of infection by NTHi and investigation of the humoral and cellular mechanisms by which the bacteria are cleared from the lung. Comparison of mucosally immunised with non-immunised animals has demonstrated that not only are bacteria cleared more rapidly from the lungs, but there is a

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5

Staffen, Dana Jean. "Environmental Factors Influence Nontypeable Haemophilus influenzae Biofilm Formation, Maturation and Gene Expression." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1385497645.

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6

Ho, Derek K. "lgtC expression mediates complement resistance in nontypeable Haemophilus influenzae strain R2866 /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/9308.

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7

McGrath, John Francis, and n/a. "Immunomodulation in the context of developing a nontypeable Haemophilus influenzae vaccine." University of Canberra. Health Sciences, 2007. http://erl.canberra.edu.au./public/adt-AUC20070726.152419.

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One of the major challenges of vaccine development is the conservation of immunogenicity and protective efficacy through the stages of design, production, formulation and delivery. The critical issue is that how and in what form an antigen is taken up by antigen presenting cells for proteolytic processing and presentation to the immune system bound to MHC can have dramatic effects on the activation of Th cells to drive clonal responses and induction of immunological memory. Nontypeable Haemophilus influenzae (NTHi) is a pathogenic commensal of the human respiratory tract that causes diseases w

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8

Spessot, Pietro. "Nontypeable Haemophilus influenzae eludes complement-mediated killing seizing C4b-binding protein." Doctoral thesis, Università di Siena, 2019. http://hdl.handle.net/11365/1078633.

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Nontypeable Haemophilus influenzae (NTHi) is a Gram negative, non-capsulated coccobacillus commensal of the nasopharyngeal tract. Acting as an opportunistic pathogen is responsible for different pathologies such as exacerbation of COPD, Otitis Media and in worst cases meningitis and sepsis. Given the great genetic variability among NTHi strains, the greatest challenge in the formulation of a vaccine against NTHi is the identification of cross protective antigens. Under the Novartis legacy (now GSK), several antigens were identified thanks to a reverse vaccinology and proteomic approaches. The

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9

Webb, Dianne, and n/a. "Nontypeable Haemophilus influenzae outer membrane protein analysis, isolation, characterisation and vaccine potential." University of Canberra. Applied Science, 1998. http://erl.canberra.edu.au./public/adt-AUC20061110.105953.

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Heterogeneity in immunodominant outer membrane proteins has been proposed as a significant factor in the failure of an NTHi infection to induce immune protection against subsequent infections. This study has examined the vaccine potential of three outer membrane proteins in an attempt to identify conserved regions that could be targeted by an immune response after vaccination. The three proteins investigated were: TbpB, P5 and P48 (HI0164). The optimal route of immunisation in clearing a bolus inoculum of NTHi to the lung in the rat has been shown to be a combination of gut sensitisation with

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10

Raffel, Forrest K. "Haemophilus Sap transporter dependent mechanisms to resist host innate and nutritional immunity influences pathogenesis." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1388669277.

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11

Månsson, Martin. "The structural diversity of lipopolysaccharides expressed by genetically defined clinical isolates of nontypeable Haemophilus influenzae /." Stockholm, 2003. http://diss.kib.ki.se/2003/91-7349-584-0.

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12

Clarke, Jodie Louise, and n/a. "Regulation of Cytokines and Chemokines during Lung Infection with Nontypeable Haemophilus influenzae." University of Canberra. n/a, 2008. http://erl.canberra.edu.au./public/adt-AUC20081210.084252.

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An animal model of respiratory infection was used to determine the effect of various factors, thought to influence the ability of the host to clear bacteria, on the host?s innate response to an NTHi lung infection. Mucosal immunisation with NTHi has previously been shown to enhance the clearance of NTHi from the lung in an animal model of infection through the increased recruitment of phagocytes. Comparisons of cytokine and chemokine kinetic profiles were made in order to determine differences between innate and acquired immune response and the way in which mucosal immunisation controls the in

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13

Yildirim, Håkan. "Structural diversity of the lipid A and core oligosaccharide moieties of the lipopolysaccharides from nontypeable and serotype f Haemophilus influenzae /." Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-504-6/.

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14

Santana, Estevan Alexis. "Identification of a Fur-regulated small regulatory RNA in nontypeable Haemophilus influenzae." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1410472201.

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15

Khalaf, Rana. "Nontypeable Haemophilus influenzae-induced inflammation, corticosteroids unresponsiveness and functional polarisation in COPD alveolar macrophages." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/nontypeable-haemophilus-influenzaeinduced-inflammation-corticosteroids-unresponsiveness-and-functional-polarisation-in-copd-alveolar-macrophages(bcbe33db-3d70-4c0b-b39d-805d448ef693).html.

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COPD is a chronic inflammatory disease of the airways where many patients have recurrent lower airway bacterial infection, most commonly nontypeable Haemophilus influenzae (NTHi). Corticosteroids are commonly used anti-inflammatory drugs in COPD with limited clinical benefit. Previous studies focused on corticosteroid responsiveness in COPD did not consider the role of airway NTHi infection. Alveolar macrophages are the main inflammatory cells in COPD pathogenesis, a shift in their phenotype was highlighted in COPD patients. Some bacteria can modify alveolar macrophage phenotype to persist in

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16

Leroy, Magali. "Genome-wide approach to vaccine target candidates identification against otitis media causing nontypeable Haemophilus influenzae." Paris 11, 2006. http://www.theses.fr/2006PA112260.

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Bien qu’il existe un vaccin contre haemophilus influenzae (hi) type b, aucun n’est disponible contre la forme non encapsulee (nthi) responsable d'infections du systeme respiratoire telle que l'otite de l'oreille moyenne. Cette infection entraine des sequelles auditives dans 20% des cas et reste la premiere cause de visite pediatrique dans les pays developpes. L’enjeu de ce travail a ete de developper un systeme permettant l'analyse de l'expression genomique durant les phases de l'infection. Et ce dans le but d’acquerir une meilleure comprehension de la pathogenese de nthi et d’identifier les a

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17

Novotny, Laura A. "Design and assessment of pre-clinical vaccine candidates against otitis media due to nontypeable Haemophilus influenzae and the development of a non-invasive vaccine delivery strategy." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/390034.

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Otitis media (OM) is one of the most common bacterial diseases of childhood and include both acute and chronic forms of disease (1). Whereas acute OM (AOM) is a disease with rapid onset and is short in duration, chronic forms of OM can persist for weeks to months. The most severe form, chronic suppurative OM (CSOM) occurs upon OM with tympanic membrane rupture and is characterized by purulent drainage from the middle ear space that persists for at least 2 weeks or longer. There are 709 million cases of acute OM and 65 million to 330 million episodes of chronic suppurative OM (CSOM) occurring e

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18

Singh, Sanjesh. "Investigation of Gram-negative bacterial surface glycans: characterisation of Moraxella bovis lipooligosaccharide and progress towards developing a Nontypeable Haemophilus influenzae/Moraxella catarrhalis vaccine candidate." Thesis, Griffith University, 2019. http://hdl.handle.net/10072/388637.

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Moraxella bovis, Moraxella catarrhalis and Nontypeable Haemophilus influenzae (NTHi) are Gram-negative, oxidase positive, pathogenic microorganisms. M. bovis causes Infectious Bovine Keratoconjunctivitis, known (IBK) as ‘pink-eye’ in cattle worldwide. The disease is of economic importance as it leads to substantial economic loss in the cattle and dairy industries. There are antibiotic treatments available to treat M. bovis associated infections, but they tend to be ineffective at controlling disease outbreaks. Importantly, the current series of antibiotics used to treat IBK have shown occurren

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19

Kyaw-Myint, Su Mon, and N/A. "Salivary IgA responses during the first two years of life: a study of aboriginal and non-aboriginal children." University of Canberra. Applied Science, 2003. http://erl.canberra.edu.au./public/adt-AUC20050523.095413.

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Nontypeable Haemophilus influenzae (NTHi), Streptococcus pneumoniae and Moraxella catarrhalis are common bacterial agents of otitis media which is a major cause of morbidity in young children. Mucosal immune responses are an integral part of the immune defense against middle ear infection and it is known that certain populations, including Australian Aboriginal children, are highly susceptible to disease. The current study focussed on the development of the mucosal immunity to the three bacterial pathogens in Aboriginal and non-Aboriginal children from birth to two years of age, living in the

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20

Novotny, Laura Anne. "Noninvasive immunization strategies to target dendritic cells and protect against experimental otitis media due to nontypeable Haemophilus influenzae." The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1299190518.

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21

Heyl, Kerstin Andrea [Verfasser], Hortense [Akademischer Betreuer] Slevogt, Peter F. [Akademischer Betreuer] Zipfel, and Robert [Akademischer Betreuer] Bals. "Die Bedeutung von Dectin-1 für die durch Nontypeable Haemophilus Influenzae (NTHi) induzierte Immunantwort des humanen Lungenepithels / Kerstin Andrea Heyl. Gutachter: Hortense Slevogt ; Peter F. Zipfel ; Robert Bals." Jena : Thüringer Universitäts- und Landesbibliothek Jena, 2014. http://d-nb.info/1052020410/34.

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22

Zhang, Yingjie. "Use of Signature-Tagged Mutagenesis to Identify the SapF Gene of Nontypeable Haemophilus Influenzae, A Gene that is Required for Survival in a Chinchilla Model of Otitis Media." The Ohio State University, 2002. http://rave.ohiolink.edu/etdc/view?acc_num=osu1407950104.

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23

Wnent, Dorothee Anna [Verfasser], Daniel [Akademischer Betreuer] Drömann та Guido [Akademischer Betreuer] Stichtenoth. "Pulmonales Geweberemodeling und Reparaturmechanismen im TGF-β Pseudorezeptor BMP and activin membrane bound inhibitor Knockout Modell nach ex vivo Infektion mit Nontypeable Haemophilus influenzae / Dorothee Anna Wnent ; Akademische Betreuer: Daniel Drömann, Guido Stichtenoth". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2021. http://d-nb.info/1232284416/34.

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24

Fernaays, Matthew Michael. "Virulence determinants of pathogenic nontypeable Haemophilus influenzae." 2008. http://proquest.umi.com/pqdweb?did=1546792641&sid=9&Fmt=2&clientId=39334&RQT=309&VName=PQD.

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Thesis (Ph.D.)--State University of New York at Buffalo, 2008.<br>Title from PDF title page (viewed on Dec. 3, 2008) Available through UMI ProQuest Digital Dissertations. Thesis adviser: Murphy, Timothy F. Includes bibliographical references.

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25

Atkinson, CT. "Acquired macrolide resistance genes in nontypeable Haemophilus influenzae." Thesis, 2017. https://eprints.utas.edu.au/23758/1/Atkinson_whole_thesis_ex_pub_mat.pdf.

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Nontypeable Haemophilus influenzae (NTHi) is an opportunistic pathogen that is associated with a range of respiratory infections, including acute exacerbations of chronic obstructive pulmonary disease (COPD), and community acquired pneumonia (CAP). Macrolide antibiotics such as azithromycin are being more frequently used to manage these conditions, including those where NTHi may be involved, despite macrolides having relatively poor antibiotic activity against H. influenzae (azithromycin MICs of wild-type strains typically cover the range of 0.25-4 μg/mL). The efficacy of these antibiotics in

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26

Atto, BA. "Potential therapeutic value of normal throat bacteria that produce a novel inhibitory substance for the prevention of respiratory infections." Thesis, 2022. https://eprints.utas.edu.au/47491/1/Atto_whole_thesis.pdf.

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Nontypeable Haemophilus influenzae (NTHi) is a major opportunistic pathogen that causes a variety of infections in the respiratory tract, including community-acquired pneumonia, acute exacerbations of chronic obstructive pulmonary disease and otitis media. Collectively, these infections and subse-quent complications impose a significant global burden of disease. The impact of NTHi-associated disease is further amplified by the rapidly expanding spectrum and prevalence of antibiotic resistance, and the lack of an effective vaccination strategy. Consequently, novel preventative or therapeutic ap

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27

Rempe, Katherine Alice. "Insights into Nonpilus Adhesin Functionality and the Molecular Determinants of Nontypeable Haemophilus influenzae Colonization." Diss., 2016. http://hdl.handle.net/10161/12136.

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<p>Bacterial colonization of the upper respiratory tract is the first step in the pathogenesis of nontypeable Haemophilus influenzae (NTHi) disease. Examination of the determinants of NTHi colonization process has been hampered by the lack of an appropriate animal model. To address this, we have developed a model of NTHi colonization in adult rhesus macaques that involves intranasal inoculation of 1x105 CFU and results in persistent colonization of the upper respiratory tract for at least three weeks with no signs of disease, mimicking asymptomatic colonization of humans. Using this model, we

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28

Singh, NK. "In vitro invasive ability of X and V factor dependent Haemophilus species across different cell types." Thesis, 2017. https://eprints.utas.edu.au/27844/1/Singh_whole_thesis.pdf.

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Nontypeable Haemophilus influenzae (NTHi) is an opportunistic human pathogen responsible for diseases such as exacerbations of chronic bronchitis, community acquired pneumonia, otitis media and occasionally conjunctivitis. H. haemolyticus is closely related to NTHi and shares the same respiratory niche as a commensal, but is not an opportunistic respiratory pathogen. Both NTHi and H. haemolyticus can acquire resistance to β-lactam antibiotics via mutations to the ftsI gene and associated amino acid substitutions in penicillin binding protein 3 (PBP3) and the prevalence of such resistant strain

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29

KC, R. "Exploring molecular mechanisms underlying the role of non-typeable Haemophilus influenzae in COPD." Thesis, 2020. https://eprints.utas.edu.au/35927/1/KC_whole_thesis_ex_pub_mat.pdf.

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Chronic obstructive pulmonary disease (COPD) is a severe and progressive condition characterised by persistent respiratory symptoms and airflow limitation. Around 300 million people in the world have COPD. It has emerged as the third leading cause of mortality, claiming 3.2 million lives worldwide in 2017. An acute exacerbation of COPD, a sudden worsening of respiratory symptoms, is a major cause of morbidity and mortality in COPD patients. Various factors, including biomass smoke exposure and infection with bacteria trigger COPD exacerbations. Nearly half of the world’s population uses biomas

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30

Obaid, NA. "Application of infra-red spectroscopy to the evaluation of biofilm formation and pathogenesis of nontypeable Haemophilus influenzae." Thesis, 2016. https://eprints.utas.edu.au/23114/1/Obaid_whole_thesis.pdf.

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Biofilm formation has been recognised as an aggregation of bacterial cells surrounded by extracellular polymeric substances (EPS) which are secreted from the cells. Biofilm has a significant role in chronicity of infection and cells are recalcitrant to antibacterial agents when biofilm is formed on abiotic or biotic surfaces. Nontypeable Haemophilus influenzae (NTHi) has been investigated previously in terms of biofilm production ability. This study examined NTHi biofilm formation using a staining assay and relationship to pathogenicity, and an assessment of the spatial distribution of

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31

Liao, Chin-Yu, and 廖謹瑜. "The study of zinc oxide nanoparticles and cigarette-smoking extracts impair nontypeable Haemophilus influenzae clearance by macrophages." Thesis, 2014. http://ndltd.ncl.edu.tw/handle/7552jw.

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碩士<br>中國醫藥大學<br>基礎醫學研究所碩士班<br>102<br>Nontypeable Haemophilus influenzae [1] is a Gram negative coccobacillus, which belongs to the normal flora of the human respiratory tract. When host immune mechanisms were defective, NTHi could invade into the lower respiratory tract, cause acute exacerbation of bronchial airway disease or chronic colonization. Previous study showed that nanomaterials (e.g., silver, iron, zinc oxide, titanium dioxide) have a variety of applications. Nanoparticles can deliver to the bloodstream or lymph nodes and then transfer to other organs, and easily penetrate the cytopl

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32

Lee, Chi-Fan, and 李啟帆. "Nontypeable Haemophilus influenzae clearance by RAW624.7 cells is impaired by exposure to cigarette smoke extract and the change of inflammatory cell profiles in NTHi challenged whole-body cigarette smoke exposure mice model." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/tvurmr.

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碩士<br>中國醫藥大學<br>基礎醫學研究所碩士班<br>105<br>From the data released by World Health Organization at 2012, Chronic Obstructive Pulmonary Disease (COPD) causes over three million deaths globally and is climbing up to the third of top ten cause of death at 2012. In many clinical studies, COPD patients usually have symptoms like sputum, long-lasting cough, chronic lung inflammation and air-flow limitation. COPD is an irreversible disease. This condition outdraws the importance of early diagnosis and the proper therapy to COPD. However, COPD is not the top ten cause of death in the low developed countries

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